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Conserved domains on  [gi|2024357255|ref|XP_040503752|]
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SUN domain-containing protein 1 isoform X2 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 762-895 3.90e-50

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


:

Pssm-ID: 400199  Cd Length: 130  Bit Score: 172.47  E-value: 3.90e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255 762 LWYFSQSPRVVIQPDMYPGNCWAFKGSEGYLVVRLSMKIYPTAFSLEHIPKTLspsgnITSAPRKFSVYGLDDEYQEEGT 841
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2024357255 842 FLGQYVYDQEGEPLQMFTVEKS-ENVFQIVELRILSNWGHAEYTCLYRFRVHGKP 895
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPpDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 530-583 2.65e-20

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


:

Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 85.02  E-value: 2.65e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2024357255 530 LEEKTDFLALHQEHNLRIITLEDLLRKLSAESKDIQKELEIAKAKTIRDGDEHN 583
Cdd:cd21439     2 PLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQQ 55
MRP super family cl09637
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 74-217 1.38e-15

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


The actual alignment was detected with superfamily member pfam09387:

Pssm-ID: 430576  Cd Length: 192  Bit Score: 76.14  E-value: 1.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  74 LHDSSYAGNVT-FRDQSSKMVKQRKSINKQSGSVRDVPRKNLSSSpifnqssflsrasdtsmvstvldeSSIReQTEVDH 152
Cdd:pfam09387  10 LDAMNQNRRAQsWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG------------------------SLIR-QTKVDH 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024357255 153 FWGSDATL-------------LQRNGDIATAetqTTMINGYTCSDCSMLSERkevLTAYSASSVPSSRIYSRDRSQKH 217
Cdd:pfam09387  65 FWGLDYHLpddgdlkggpkaaPQGNGDRAVS---VALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQKN 136
HTH_SUN2 super family cl39899
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 661-719 5.52e-09

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


The actual alignment was detected with superfamily member pfam18580:

Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 53.10  E-value: 5.52e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024357255 661 LQTLLQDLELQILKNITvQMAVTNQRITSEVVTNAVNNAGISGITEAQAQIIVNNALKL 719
Cdd:pfam18580   1 LQAQLQDLEQRILAKLA-EEQGKSARDAAASVGVALQQEGVTGVTEEQVHRIVNQALKR 58
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 466-712 4.68e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 4.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  466 SARISELEKQMAFVSDRCHHHDEEYSKvllllhnLQDQVAQMGNRNEILKLIKNVMDQHLKD-----KRLEEKTD-FLAL 539
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEE-------LEAQLEELESKLDELAEELAELEEKLEElkeelESLEAELEeLEAE 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  540 HQEHNLRIITLEDLLRKLSAESKDIQKELEIAKAKTIRDGDEHNQLLSRVKKLELELSQVKSELLTGE--SVKTSCEKID 617
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElkELQAELEELE 446

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  618 VIHEKVDAQVKESVKMMLFGDQHKDFPESLLQWLTSNFVTRSDLQTLLQDLELQILKNitvqmavtnqritSEVVTNAVN 697
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGF-------------SEGVKALLK 513

                          250
                   ....*....|....*.
gi 2024357255  698 NA-GISGITEAQAQII 712
Cdd:TIGR02168  514 NQsGLSGILGVLSELI 529
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 762-895 3.90e-50

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 172.47  E-value: 3.90e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255 762 LWYFSQSPRVVIQPDMYPGNCWAFKGSEGYLVVRLSMKIYPTAFSLEHIPKTLspsgnITSAPRKFSVYGLDDEYQEEGT 841
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2024357255 842 FLGQYVYDQEGEPLQMFTVEKS-ENVFQIVELRILSNWGHAEYTCLYRFRVHGKP 895
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPpDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 530-583 2.65e-20

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 85.02  E-value: 2.65e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2024357255 530 LEEKTDFLALHQEHNLRIITLEDLLRKLSAESKDIQKELEIAKAKTIRDGDEHN 583
Cdd:cd21439     2 PLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQQ 55
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 74-217 1.38e-15

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 76.14  E-value: 1.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  74 LHDSSYAGNVT-FRDQSSKMVKQRKSINKQSGSVRDVPRKNLSSSpifnqssflsrasdtsmvstvldeSSIReQTEVDH 152
Cdd:pfam09387  10 LDAMNQNRRAQsWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG------------------------SLIR-QTKVDH 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024357255 153 FWGSDATL-------------LQRNGDIATAetqTTMINGYTCSDCSMLSERkevLTAYSASSVPSSRIYSRDRSQKH 217
Cdd:pfam09387  65 FWGLDYHLpddgdlkggpkaaPQGNGDRAVS---VALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQKN 136
HTH_SUN2 pfam18580
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 661-719 5.52e-09

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 53.10  E-value: 5.52e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024357255 661 LQTLLQDLELQILKNITvQMAVTNQRITSEVVTNAVNNAGISGITEAQAQIIVNNALKL 719
Cdd:pfam18580   1 LQAQLQDLEQRILAKLA-EEQGKSARDAAASVGVALQQEGVTGVTEEQVHRIVNQALKR 58
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 466-712 4.68e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 4.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  466 SARISELEKQMAFVSDRCHHHDEEYSKvllllhnLQDQVAQMGNRNEILKLIKNVMDQHLKD-----KRLEEKTD-FLAL 539
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEE-------LEAQLEELESKLDELAEELAELEEKLEElkeelESLEAELEeLEAE 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  540 HQEHNLRIITLEDLLRKLSAESKDIQKELEIAKAKTIRDGDEHNQLLSRVKKLELELSQVKSELLTGE--SVKTSCEKID 617
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElkELQAELEELE 446

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  618 VIHEKVDAQVKESVKMMLFGDQHKDFPESLLQWLTSNFVTRSDLQTLLQDLELQILKNitvqmavtnqritSEVVTNAVN 697
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGF-------------SEGVKALLK 513

                          250
                   ....*....|....*.
gi 2024357255  698 NA-GISGITEAQAQII 712
Cdd:TIGR02168  514 NQsGLSGILGVLSELI 529
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 762-895 3.90e-50

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 172.47  E-value: 3.90e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255 762 LWYFSQSPRVVIQPDMYPGNCWAFKGSEGYLVVRLSMKIYPTAFSLEHIPKTLspsgnITSAPRKFSVYGLDDEYQEEGT 841
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2024357255 842 FLGQYVYDQEGEPLQMFTVEKS-ENVFQIVELRILSNWGHAEYTCLYRFRVHGKP 895
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPpDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 530-583 2.65e-20

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 85.02  E-value: 2.65e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2024357255 530 LEEKTDFLALHQEHNLRIITLEDLLRKLSAESKDIQKELEIAKAKTIRDGDEHN 583
Cdd:cd21439     2 PLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQQ 55
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 74-217 1.38e-15

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 76.14  E-value: 1.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  74 LHDSSYAGNVT-FRDQSSKMVKQRKSINKQSGSVRDVPRKNLSSSpifnqssflsrasdtsmvstvldeSSIReQTEVDH 152
Cdd:pfam09387  10 LDAMNQNRRAQsWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG------------------------SLIR-QTKVDH 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024357255 153 FWGSDATL-------------LQRNGDIATAetqTTMINGYTCSDCSMLSERkevLTAYSASSVPSSRIYSRDRSQKH 217
Cdd:pfam09387  65 FWGLDYHLpddgdlkggpkaaPQGNGDRAVS---VALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQKN 136
HTH_SUN2 pfam18580
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 661-719 5.52e-09

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 53.10  E-value: 5.52e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024357255 661 LQTLLQDLELQILKNITvQMAVTNQRITSEVVTNAVNNAGISGITEAQAQIIVNNALKL 719
Cdd:pfam18580   1 LQAQLQDLEQRILAKLA-EEQGKSARDAAASVGVALQQEGVTGVTEEQVHRIVNQALKR 58
SUN_cc1 cd21435
coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 ...
 533-576 3.08e-05

coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 and SUN2) are components of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN proteins contain two coiled-coil domains (CC1 and CC2), which act as intrinsic dynamic regulators controlling the activity of the SUN domain. The model corresponds to CC1 that functions as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410603 [Multi-domain]  Cd Length: 55  Bit Score: 42.39  E-value: 3.08e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2024357255 533 KTDFLALHQEHNLRIITLEDLLRKLSAESKDIQKELEIAKAKTI 576
Cdd:cd21435     5 QESSVKELGRLEAQLASLRQELAALTLKQEAIQKELEQTKQKTI 48
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 466-712 4.68e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 4.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  466 SARISELEKQMAFVSDRCHHHDEEYSKvllllhnLQDQVAQMGNRNEILKLIKNVMDQHLKD-----KRLEEKTD-FLAL 539
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEE-------LEAQLEELESKLDELAEELAELEEKLEElkeelESLEAELEeLEAE 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  540 HQEHNLRIITLEDLLRKLSAESKDIQKELEIAKAKTIRDGDEHNQLLSRVKKLELELSQVKSELLTGE--SVKTSCEKID 617
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElkELQAELEELE 446

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357255  618 VIHEKVDAQVKESVKMMLFGDQHKDFPESLLQWLTSNFVTRSDLQTLLQDLELQILKNitvqmavtnqritSEVVTNAVN 697
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGF-------------SEGVKALLK 513

                          250
                   ....*....|....*.
gi 2024357255  698 NA-GISGITEAQAQII 712
Cdd:TIGR02168  514 NQsGLSGILGVLSELI 529
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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