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Conserved domains on  [gi|2024361722|ref|XP_040505063|]
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protein crumbs homolog 2 isoform X4 [Gallus gallus]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 561-722 5.25e-19

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 85.16  E-value: 5.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  561 TFSFASRGYLLIELPVNNQSRrevageqlASVSLRFRTTLPSAILFYRG--HEAEYLFLELLDGILRTELKRQDEYLLLL 638
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR--------LSISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSGSLVLS 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  639 EELRVDDGHWHKVEVVLQ-NTVQLKLwhdscDAGVCMQSSPIPHNATPIPHAFLsvYIGGAQDPLANNTQ-SQQGFVGCL 716
Cdd:cd00110     73 SKTPLNDGQWHSVSVERNgRSVTLSV-----DGERVVESGSPGGSALLNLDGPL--YLGGLPEDLKSPGLpVSPGFVGCI 145


                   ....*.
gi 2024361722  717 EDLQVD 722
Cdd:cd00110    146 RDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 816-933 2.60e-14

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 70.91  E-value: 2.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  816 IRSLKPNGLLLQISNETDPCLTIYLKNGKLKIEM----LSTDTVTFPENLVDGRRHLVALSFQGGIVGVHQPDTYVELGQ 891
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYdlgsGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2024361722  892 LVGRP--LLAGYDVYIGGRPDPDSTDL--WGGYFKGCLQDIQLNGH 933
Cdd:pfam02210   81 PPGESllLNLNGPLYLGGLPPLLLLPAlpVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1028-1169 5.98e-12

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 64.75  E-value: 5.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722 1028 ATFNSSATIEFTTNTSVTRTLgSLLMDFRTRDEDAVLLRAMEEV--DSLQIAIKNSSLLVDIRSGNsiEGVSFLSQNAVT 1105
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTRL-SISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGS--GSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024361722 1106 DGAWHTISLSMEEPSAL----SSRWVAHLDGSINMTLQGNA----GNLDFLKNNALIVLAENFTGCLGQVKI 1169
Cdd:cd00110     79 DGQWHSVSVERNGRSVTlsvdGERVVESGSPGGSALLNLDGplylGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-223 1.47e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722  187 NIDECAS-NPCQNGAICRDRVNEYSCFCVPGFQGYNCE 223
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 225-261 2.02e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722  225 DINECASR-PCKNNGTCLNEMDHYLCKCIPGYTGVNCE 261
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 436-471 3.01e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.01e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024361722  436 NINECESQ-PCQNGGHCVDLVDGFLCHCLPGYSGVEC 471
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 301-338 3.04e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.04e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2024361722  301 DINEC-ISQPCQHNGTCHDLINSYQCDCSDtGFEGDHCE 338
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 264-299 2.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024361722  264 IDECDSY-PCQNGALCSDHIGFYTCTCMPGYQGIQCE 299
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 154-185 9.32e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 9.32e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024361722  154 SSHLCLNNGTCVEGPGDYACICQPGFTGAHCK 185
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 965-999 2.83e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.83e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024361722  965 NTCKSE-PCQNGGRCIVTWNDFHCSCPANFTGKFCE 999
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1277-1313 3.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.98e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722 1277 NVDDCV-RHQCQNGATCIDGVYGYSCKCPAQYSGPRCE 1313
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 340-376 3.26e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722  340 DILECASE-PCLNNATCVEGIKNYSCACWTGYTGQHCE 376
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1206-1238 4.09e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 4.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024361722 1206 CAS-SPCSNAGTCRDLFNSFSCACSAGWEGLLCE 1238
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
474-502 1.62e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.62e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2024361722   474 NINECEE-GPCKNGAVCEDGIADYTCHCAP 502
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPP 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 749-778 6.51e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.51e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024361722  749 CLSEPCFHGGLCVDLWTTFRCDCLRPYGGP 778
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 561-722 5.25e-19

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 85.16  E-value: 5.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  561 TFSFASRGYLLIELPVNNQSRrevageqlASVSLRFRTTLPSAILFYRG--HEAEYLFLELLDGILRTELKRQDEYLLLL 638
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR--------LSISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSGSLVLS 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  639 EELRVDDGHWHKVEVVLQ-NTVQLKLwhdscDAGVCMQSSPIPHNATPIPHAFLsvYIGGAQDPLANNTQ-SQQGFVGCL 716
Cdd:cd00110     73 SKTPLNDGQWHSVSVERNgRSVTLSV-----DGERVVESGSPGGSALLNLDGPL--YLGGLPEDLKSPGLpVSPGFVGCI 145


                   ....*.
gi 2024361722  717 EDLQVD 722
Cdd:cd00110    146 RDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 596-724 1.91e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.77  E-value: 1.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  596 FRTTLPSAILFYRG-HEAEYLFLELLDGILRTELK-RQDEYLLLLEELRVDDGHWHKVEVVL-QNTVQLKLwhDSCdagv 672
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDlGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV--DGQ---- 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024361722  673 cMQSSPIPHNATPIPHAFLSVYIGGAQDPLAN-NTQSQQGFVGCLEDLQVDAE 724
Cdd:pfam02210   75 -TVVSSLPPGESLLLNLNGPLYLGGLPPLLLLpALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
591-722 6.33e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 72.76  E-value: 6.33e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722   591 SVSLRFRTTLPSAILFYRGHEA--EYLFLELLDGILRTELKR-QDEYLLLLEELRVDDGHWHKVEVVLQNTvQLKLWHDS 667
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLgSGPARLTSDPTPLNDGQWHRVAVERNGR-SVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024361722   668 CDAgvcmQSSPIPHNATPIpHAFLSVYIGGAQDPLAN-NTQSQQGFVGCLEDLQVD 722
Cdd:smart00282   80 GNR----VSGESPGGLTIL-NLDGPLYLGGLPEDLKLpPLPVTPGFRGCIRNLKVN 130
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 816-933 2.60e-14

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 70.91  E-value: 2.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  816 IRSLKPNGLLLQISNETDPCLTIYLKNGKLKIEM----LSTDTVTFPENLVDGRRHLVALSFQGGIVGVHQPDTYVELGQ 891
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYdlgsGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2024361722  892 LVGRP--LLAGYDVYIGGRPDPDSTDL--WGGYFKGCLQDIQLNGH 933
Cdd:pfam02210   81 PPGESllLNLNGPLYLGGLPPLLLLPAlpVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 786-931 2.89e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 71.68  E-value: 2.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  786 AVTFGlenSTSFSSFILSDSLGADFNISFFIRSLKPNGLLLQISN-ETDPCLTIYLKNGKLKIEM---LSTDTVTFPENL 861
Cdd:cd00110      1 GVSFS---GSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYdlgSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024361722  862 VDGRRHLVALSFQGGIVGVhQPDTY--VELGQLVGRPLL-AGYDVYIGGRPDPDST--DLWGGYFKGCLQDIQLN 931
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTL-SVDGErvVESGSPGGSALLnLDGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1028-1169 5.98e-12

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 64.75  E-value: 5.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722 1028 ATFNSSATIEFTTNTSVTRTLgSLLMDFRTRDEDAVLLRAMEEV--DSLQIAIKNSSLLVDIRSGNsiEGVSFLSQNAVT 1105
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTRL-SISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGS--GSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024361722 1106 DGAWHTISLSMEEPSAL----SSRWVAHLDGSINMTLQGNA----GNLDFLKNNALIVLAENFTGCLGQVKI 1169
Cdd:cd00110     79 DGQWHSVSVERNGRSVTlsvdGERVVESGSPGGSALLNLDGplylGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
811-933 1.49e-11

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 63.13  E-value: 1.49e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722   811 NISFFIRSLKPNGLLLQI-SNETDPCLTIYLKNGKLK--IEMLSTDTVTFPENLV--DGRRHLVALSFQGGIVGVH--QP 883
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVlrYDLGSGPARLTSDPTPlnDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024361722   884 DTYVELGQLVGRPLLAGYDVYIGGRPDPDST--DLWGGYFKGCLQDIQLNGH 933
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1055-1172 1.37e-10

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 60.13  E-value: 1.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722 1055 FRTRDEDAVLLRAMEEV-DSLQIAIKNSSLLVDIRSGNSIEGVSFLSQNaVTDGAWHTISLSMEEPSA-LS---SRWVAH 1129
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGsDFLALELVNGRLVLRYDLGSGPESLLSSGKN-LNDGQWHSVRVERNGNTLtLSvdgQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2024361722 1130 LDGSINMTLQGNA----GNLDFLKNNALIVLAENFTGCLGQVKIGGI 1172
Cdd:pfam02210   80 LPPGESLLLNLNGplylGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1050-1171 2.56e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.58  E-value: 2.56e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  1050 SLLMDFRTRDEDAVLLRAM--EEVDSLQIAIKNSSLLVDIRSGNSIEGVSfLSQNAVTDGAWHTISLSMEEPSAL----- 1122
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVTlsvdg 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024361722  1123 SSRWVAHLDGSI-NMTLQGN--AGNLDFLKNNALIVLAENFTGCLGQVKIGG 1171
Cdd:smart00282   80 GNRVSGESPGGLtILNLDGPlyLGGLPEDLKLPPLPVTPGFRGCIRNLKVNG 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-223 1.47e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722  187 NIDECAS-NPCQNGAICRDRVNEYSCFCVPGFQGYNCE 223
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 225-261 2.02e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722  225 DINECASR-PCKNNGTCLNEMDHYLCKCIPGYTGVNCE 261
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 436-471 3.01e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.01e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024361722  436 NINECESQ-PCQNGGHCVDLVDGFLCHCLPGYSGVEC 471
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 301-338 3.04e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.04e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2024361722  301 DINEC-ISQPCQHNGTCHDLINSYQCDCSDtGFEGDHCE 338
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
187-223 1.60e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.60e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722   187 NIDECAS-NPCQNGAICRDRVNEYSCFCVPGFQ-GYNCE 223
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 264-299 2.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024361722  264 IDECDSY-PCQNGALCSDHIGFYTCTCMPGYQGIQCE 299
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
436-467 2.28e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.28e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2024361722   436 NINECES-QPCQNGGHCVDLVDGFLCHCLPGYS 467
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
301-338 3.06e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.06e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722   301 DINECIS-QPCQHNGTCHDLINSYQCDCSDTGFEGDHCE 338
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 154-185 9.32e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 9.32e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024361722  154 SSHLCLNNGTCVEGPGDYACICQPGFTGAHCK 185
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
225-261 1.53e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.53e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722   225 DINECASR-PCKNNGTCLNEMDHYLCKCIPGYT-GVNCE 261
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 965-999 2.83e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.83e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024361722  965 NTCKSE-PCQNGGRCIVTWNDFHCSCPANFTGKFCE 999
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1277-1313 3.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.98e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722 1277 NVDDCV-RHQCQNGATCIDGVYGYSCKCPAQYSGPRCE 1313
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
263-299 4.17e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.17e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722   263 EIDECDSY-PCQNGALCSDHIGFYTCTCMPGYQ-GIQCE 299
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 153-183 5.28e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 5.28e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722  153 CSSHLCLNNGTCVEGPGDYACICQPGFTGAH 183
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 967-997 7.22e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 7.22e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722  967 CKSEPCQNGGRCIVTWNDFHCSCPANFTGKF 997
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 440-468 1.93e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 1.93e-04
                           10        20
                   ....*....|....*....|....*....
gi 2024361722  440 CESQPCQNGGHCVDLVDGFLCHCLPGYSG 468
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 340-376 3.26e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722  340 DILECASE-PCLNNATCVEGIKNYSCACWTGYTGQHCE 376
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 191-219 3.28e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 3.28e-04
                           10        20
                   ....*....|....*....|....*....
gi 2024361722  191 CASNPCQNGAICRDRVNEYSCFCVPGFQG 219
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1206-1238 4.09e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 4.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024361722 1206 CAS-SPCSNAGTCRDLFNSFSCACSAGWEGLLCE 1238
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 229-259 1.21e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.21e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722  229 CASRPCKNNGTCLNEMDHYLCKCIPGYTGVN 259
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1277-1313 1.60e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.60e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722  1277 NVDDCV-RHQCQNGATCIDGVYGYSCKCPAQYS-GPRCE 1313
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
474-502 1.62e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.62e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2024361722   474 NINECEE-GPCKNGAVCEDGIADYTCHCAP 502
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
154-185 1.78e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.78e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2024361722   154 SSHLCLNNGTCVEGPGDYACICQPGFT-GAHCK 185
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1281-1311 3.27e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.27e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722 1281 CVRHQCQNGATCIDGVYGYSCKCPAQYSGPR 1311
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 749-778 6.51e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.51e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024361722  749 CLSEPCFHGGLCVDLWTTFRCDCLRPYGGP 778
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
958-999 6.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 6.55e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2024361722   958 VNGCISDNtcksePCQNGGRCIVTWNDFHCSCPANFT-GKFCE 999
Cdd:smart00179    2 IDECASGN-----PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 474-502 6.64e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.64e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024361722  474 NINECEEG-PCKNGAVCEDGIADYTCHCAP 502
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPP 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 267-295 6.77e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.77e-03
                           10        20
                   ....*....|....*....|....*....
gi 2024361722  267 CDSYPCQNGALCSDHIGFYTCTCMPGYQG 295
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 344-374 7.69e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.69e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722  344 CASEPCLNNATCVEGIKNYSCACWTGYTGQH 374
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 561-722 5.25e-19

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 85.16  E-value: 5.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  561 TFSFASRGYLLIELPVNNQSRrevageqlASVSLRFRTTLPSAILFYRG--HEAEYLFLELLDGILRTELKRQDEYLLLL 638
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR--------LSISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSGSLVLS 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  639 EELRVDDGHWHKVEVVLQ-NTVQLKLwhdscDAGVCMQSSPIPHNATPIPHAFLsvYIGGAQDPLANNTQ-SQQGFVGCL 716
Cdd:cd00110     73 SKTPLNDGQWHSVSVERNgRSVTLSV-----DGERVVESGSPGGSALLNLDGPL--YLGGLPEDLKSPGLpVSPGFVGCI 145


                   ....*.
gi 2024361722  717 EDLQVD 722
Cdd:cd00110    146 RDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 596-724 1.91e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.77  E-value: 1.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  596 FRTTLPSAILFYRG-HEAEYLFLELLDGILRTELK-RQDEYLLLLEELRVDDGHWHKVEVVL-QNTVQLKLwhDSCdagv 672
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDlGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV--DGQ---- 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024361722  673 cMQSSPIPHNATPIPHAFLSVYIGGAQDPLAN-NTQSQQGFVGCLEDLQVDAE 724
Cdd:pfam02210   75 -TVVSSLPPGESLLLNLNGPLYLGGLPPLLLLpALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
591-722 6.33e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 72.76  E-value: 6.33e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722   591 SVSLRFRTTLPSAILFYRGHEA--EYLFLELLDGILRTELKR-QDEYLLLLEELRVDDGHWHKVEVVLQNTvQLKLWHDS 667
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLgSGPARLTSDPTPLNDGQWHRVAVERNGR-SVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024361722   668 CDAgvcmQSSPIPHNATPIpHAFLSVYIGGAQDPLAN-NTQSQQGFVGCLEDLQVD 722
Cdd:smart00282   80 GNR----VSGESPGGLTIL-NLDGPLYLGGLPEDLKLpPLPVTPGFRGCIRNLKVN 130
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 816-933 2.60e-14

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 70.91  E-value: 2.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  816 IRSLKPNGLLLQISNETDPCLTIYLKNGKLKIEM----LSTDTVTFPENLVDGRRHLVALSFQGGIVGVHQPDTYVELGQ 891
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYdlgsGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2024361722  892 LVGRP--LLAGYDVYIGGRPDPDSTDL--WGGYFKGCLQDIQLNGH 933
Cdd:pfam02210   81 PPGESllLNLNGPLYLGGLPPLLLLPAlpVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 786-931 2.89e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 71.68  E-value: 2.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  786 AVTFGlenSTSFSSFILSDSLGADFNISFFIRSLKPNGLLLQISN-ETDPCLTIYLKNGKLKIEM---LSTDTVTFPENL 861
Cdd:cd00110      1 GVSFS---GSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYdlgSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024361722  862 VDGRRHLVALSFQGGIVGVhQPDTY--VELGQLVGRPLL-AGYDVYIGGRPDPDST--DLWGGYFKGCLQDIQLN 931
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTL-SVDGErvVESGSPGGSALLnLDGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1028-1169 5.98e-12

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 64.75  E-value: 5.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722 1028 ATFNSSATIEFTTNTSVTRTLgSLLMDFRTRDEDAVLLRAMEEV--DSLQIAIKNSSLLVDIRSGNsiEGVSFLSQNAVT 1105
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTRL-SISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGS--GSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024361722 1106 DGAWHTISLSMEEPSAL----SSRWVAHLDGSINMTLQGNA----GNLDFLKNNALIVLAENFTGCLGQVKI 1169
Cdd:cd00110     79 DGQWHSVSVERNGRSVTlsvdGERVVESGSPGGSALLNLDGplylGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
811-933 1.49e-11

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 63.13  E-value: 1.49e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722   811 NISFFIRSLKPNGLLLQI-SNETDPCLTIYLKNGKLK--IEMLSTDTVTFPENLV--DGRRHLVALSFQGGIVGVH--QP 883
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVlrYDLGSGPARLTSDPTPlnDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024361722   884 DTYVELGQLVGRPLLAGYDVYIGGRPDPDST--DLWGGYFKGCLQDIQLNGH 933
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1055-1172 1.37e-10

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 60.13  E-value: 1.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722 1055 FRTRDEDAVLLRAMEEV-DSLQIAIKNSSLLVDIRSGNSIEGVSFLSQNaVTDGAWHTISLSMEEPSA-LS---SRWVAH 1129
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGsDFLALELVNGRLVLRYDLGSGPESLLSSGKN-LNDGQWHSVRVERNGNTLtLSvdgQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2024361722 1130 LDGSINMTLQGNA----GNLDFLKNNALIVLAENFTGCLGQVKIGGI 1172
Cdd:pfam02210   80 LPPGESLLLNLNGplylGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
596-722 8.19e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 58.10  E-value: 8.19e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  596 FRTTLPSAILFYRGH--EAEYLFLELLDGILRTELKRQDEYLLLLEELRVDDGHWHKVEVVlQNTVQLKLWHDSCDagVC 673
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqtERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELE-RNGRSGTLSVDGEA--RP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024361722  674 MQSSPIPHNATPI-PHAFlsvYIGGAQD------PLANNTqsqqGFVGCLEDLQVD 722
Cdd:pfam00054   78 TGESPLGATTDLDvDGPL---YVGGLPSlgvkkrRLAISP----SFDGCIRDVIVN 126
LamG smart00282
Laminin G domain;
1050-1171 2.56e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.58  E-value: 2.56e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  1050 SLLMDFRTRDEDAVLLRAM--EEVDSLQIAIKNSSLLVDIRSGNSIEGVSfLSQNAVTDGAWHTISLSMEEPSAL----- 1122
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVTlsvdg 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024361722  1123 SSRWVAHLDGSI-NMTLQGN--AGNLDFLKNNALIVLAENFTGCLGQVKIGG 1171
Cdd:smart00282   80 GNRVSGESPGGLtILNLDGPlyLGGLPEDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
816-936 5.44e-08

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 53.09  E-value: 5.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024361722  816 IRSLKPNGLLLQISNETDP-CLTIYLKNGKLKIEM--LSTDTVTF-PENLVDGRRHLVALSFQGGIV-----GVHQPDTY 886
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERdFLALELRDGRLEVSYdlGSGAAVVRsGDKLNDGKWHSVELERNGRSGtlsvdGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024361722  887 VELGQLVgrPLLAGYDVYIGGRPDpDSTDLWGG----YFKGCLQDIQLNGHQIE 936
Cdd:pfam00054   81 SPLGATT--DLDVDGPLYVGGLPS-LGVKKRRLaispSFDGCIRDVIVNGKPLD 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-223 1.47e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722  187 NIDECAS-NPCQNGAICRDRVNEYSCFCVPGFQGYNCE 223
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 225-261 2.02e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722  225 DINECASR-PCKNNGTCLNEMDHYLCKCIPGYTGVNCE 261
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 436-471 3.01e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.01e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024361722  436 NINECESQ-PCQNGGHCVDLVDGFLCHCLPGYSGVEC 471
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 301-338 3.04e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.04e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2024361722  301 DINEC-ISQPCQHNGTCHDLINSYQCDCSDtGFEGDHCE 338
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
187-223 1.60e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.60e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722   187 NIDECAS-NPCQNGAICRDRVNEYSCFCVPGFQ-GYNCE 223
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 264-299 2.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024361722  264 IDECDSY-PCQNGALCSDHIGFYTCTCMPGYQGIQCE 299
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
436-467 2.28e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.28e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2024361722   436 NINECES-QPCQNGGHCVDLVDGFLCHCLPGYS 467
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
301-338 3.06e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.06e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722   301 DINECIS-QPCQHNGTCHDLINSYQCDCSDTGFEGDHCE 338
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 154-185 9.32e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 9.32e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024361722  154 SSHLCLNNGTCVEGPGDYACICQPGFTGAHCK 185
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
225-261 1.53e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.53e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722   225 DINECASR-PCKNNGTCLNEMDHYLCKCIPGYT-GVNCE 261
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 965-999 2.83e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.83e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024361722  965 NTCKSE-PCQNGGRCIVTWNDFHCSCPANFTGKFCE 999
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1277-1313 3.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.98e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722 1277 NVDDCV-RHQCQNGATCIDGVYGYSCKCPAQYSGPRCE 1313
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
263-299 4.17e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.17e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722   263 EIDECDSY-PCQNGALCSDHIGFYTCTCMPGYQ-GIQCE 299
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 153-183 5.28e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 5.28e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722  153 CSSHLCLNNGTCVEGPGDYACICQPGFTGAH 183
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 967-997 7.22e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 7.22e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722  967 CKSEPCQNGGRCIVTWNDFHCSCPANFTGKF 997
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 440-468 1.93e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 1.93e-04
                           10        20
                   ....*....|....*....|....*....
gi 2024361722  440 CESQPCQNGGHCVDLVDGFLCHCLPGYSG 468
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 340-376 3.26e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024361722  340 DILECASE-PCLNNATCVEGIKNYSCACWTGYTGQHCE 376
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 191-219 3.28e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 3.28e-04
                           10        20
                   ....*....|....*....|....*....
gi 2024361722  191 CASNPCQNGAICRDRVNEYSCFCVPGFQG 219
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1206-1238 4.09e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 4.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024361722 1206 CAS-SPCSNAGTCRDLFNSFSCACSAGWEGLLCE 1238
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 229-259 1.21e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.21e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722  229 CASRPCKNNGTCLNEMDHYLCKCIPGYTGVN 259
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 445-466 1.49e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 37.31  E-value: 1.49e-03
                           10        20
                   ....*....|....*....|..
gi 2024361722  445 CQNGGHCVDLVDGFLCHCLPGY 466
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 190-223 1.54e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024361722  190 ECA-SNPCQNGAICRDRVNEYSCFCVPGFQG-YNCE 223
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1277-1313 1.60e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.60e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024361722  1277 NVDDCV-RHQCQNGATCIDGVYGYSCKCPAQYS-GPRCE 1313
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
474-502 1.62e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.62e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2024361722   474 NINECEE-GPCKNGAVCEDGIADYTCHCAP 502
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
154-185 1.78e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.78e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2024361722   154 SSHLCLNNGTCVEGPGDYACICQPGFT-GAHCK 185
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 439-468 3.26e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 3.26e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722  439 ECE-SQPCQNGGHCVDLVDGFLCHCLPGYSG 468
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1281-1311 3.27e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.27e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722 1281 CVRHQCQNGATCIDGVYGYSCKCPAQYSGPR 1311
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 154-183 3.70e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 3.70e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024361722  154 SSHLCLNNGTCVEGPGDYACICQPGFTGAH 183
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 749-778 6.51e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.51e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024361722  749 CLSEPCFHGGLCVDLWTTFRCDCLRPYGGP 778
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
958-999 6.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 6.55e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2024361722   958 VNGCISDNtcksePCQNGGRCIVTWNDFHCSCPANFT-GKFCE 999
Cdd:smart00179    2 IDECASGN-----PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 474-502 6.64e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.64e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024361722  474 NINECEEG-PCKNGAVCEDGIADYTCHCAP 502
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPP 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 267-295 6.77e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.77e-03
                           10        20
                   ....*....|....*....|....*....
gi 2024361722  267 CDSYPCQNGALCSDHIGFYTCTCMPGYQG 295
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 344-374 7.69e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.69e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024361722  344 CASEPCLNNATCVEGIKNYSCACWTGYTGQH 374
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 969-997 9.53e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 9.53e-03
                           10        20
                   ....*....|....*....|....*....
gi 2024361722  969 SEPCQNGGRCIVTWNDFHCSCPANFTGKF 997
Cdd:cd00053      5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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