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Conserved domains on  [gi|2024439333|ref|XP_040513925|]
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thyroid transcription factor 1-associated protein 26 [Gallus gallus]

Protein Classification

thyroid transcription factor 1-associated protein 26( domain architecture ID 709383)

thyroid transcription factor (TTF) 1-associated protein 26 (TAP26) similar to human TAP26 which interact with TTF-1 and enhance TTF-1-transactivated SP-B promoter activity.

Gene Ontology:  GO:0003723
PubMed:  12882447

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rRNA_processing super family cl26553
rRNA processing; This is a family of proteins that are involved in rRNA processing. In a ...
 130-203 1.14e-06

rRNA processing; This is a family of proteins that are involved in rRNA processing. In a localization study they were found to localize to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.


The actual alignment was detected with superfamily member pfam08524:

Pssm-ID: 400708 [Multi-domain]  Cd Length: 142  Bit Score: 46.15  E-value: 1.14e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024439333 130 KTSNQKAKEEYEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKMEAYKVLSKKTKKGQPNLNAQMEFLLQKIQQ 203
Cdd:pfam08524  68 KTKFDERKEIKKERKEEKRERKLEARQKKLERIKALEKKKKEREKRKKQLSKKTKKGQPVMGPRIEDLLDKIKK 141
PTZ00121 super family cl31754
MAEBL; Provisional
 43-187 9.08e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 9.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024439333   43 QQGRGFAFRR----KQKIERKYRKLLKKEQKICSPQADQFTDTYPEHLKHLYLAEEERLKKqhKSPNHSVLSEERLNKAV 118
Cdd:PTZ00121  1573 EEDKNMALRKaeeaKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK--KVEQLKKKEAEEKKKAE 1650

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024439333  119 EPVTTEGKFKKKTSNQKAKEEYEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKMEAYKVLSKKTKKGQ 187
Cdd:PTZ00121  1651 ELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE 1719
 
Name Accession Description Interval E-value
rRNA_processing pfam08524
rRNA processing; This is a family of proteins that are involved in rRNA processing. In a ...
 130-203 1.14e-06

rRNA processing; This is a family of proteins that are involved in rRNA processing. In a localization study they were found to localize to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.


Pssm-ID: 400708 [Multi-domain]  Cd Length: 142  Bit Score: 46.15  E-value: 1.14e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024439333 130 KTSNQKAKEEYEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKMEAYKVLSKKTKKGQPNLNAQMEFLLQKIQQ 203
Cdd:pfam08524  68 KTKFDERKEIKKERKEEKRERKLEARQKKLERIKALEKKKKEREKRKKQLSKKTKKGQPVMGPRIEDLLDKIKK 141
PTZ00121 PTZ00121
MAEBL; Provisional
 43-187 9.08e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 9.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024439333   43 QQGRGFAFRR----KQKIERKYRKLLKKEQKICSPQADQFTDTYPEHLKHLYLAEEERLKKqhKSPNHSVLSEERLNKAV 118
Cdd:PTZ00121  1573 EEDKNMALRKaeeaKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK--KVEQLKKKEAEEKKKAE 1650

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024439333  119 EPVTTEGKFKKKTSNQKAKEEYEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKMEAYKVLSKKTKKGQ 187
Cdd:PTZ00121  1651 ELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE 1719
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 135-200 4.48e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 37.23  E-value: 4.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024439333 135 KAKEEyEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKMEAykvlsKKTKKGQPNLNAQMEFLLQK 200
Cdd:PRK05035  439 RAIEQ-EKKKAEEAKARFEARQARLEREKAAREARHKKAAE-----ARAAKDKDAVAAALARVKAK 498
 
Name Accession Description Interval E-value
rRNA_processing pfam08524
rRNA processing; This is a family of proteins that are involved in rRNA processing. In a ...
 130-203 1.14e-06

rRNA processing; This is a family of proteins that are involved in rRNA processing. In a localization study they were found to localize to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.


Pssm-ID: 400708 [Multi-domain]  Cd Length: 142  Bit Score: 46.15  E-value: 1.14e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024439333 130 KTSNQKAKEEYEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKMEAYKVLSKKTKKGQPNLNAQMEFLLQKIQQ 203
Cdd:pfam08524  68 KTKFDERKEIKKERKEEKRERKLEARQKKLERIKALEKKKKEREKRKKQLSKKTKKGQPVMGPRIEDLLDKIKK 141
PTZ00121 PTZ00121
MAEBL; Provisional
 43-187 9.08e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 9.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024439333   43 QQGRGFAFRR----KQKIERKYRKLLKKEQKICSPQADQFTDTYPEHLKHLYLAEEERLKKqhKSPNHSVLSEERLNKAV 118
Cdd:PTZ00121  1573 EEDKNMALRKaeeaKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK--KVEQLKKKEAEEKKKAE 1650

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024439333  119 EPVTTEGKFKKKTSNQKAKEEYEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKMEAYKVLSKKTKKGQ 187
Cdd:PTZ00121  1651 ELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE 1719
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 135-200 4.48e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 37.23  E-value: 4.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024439333 135 KAKEEyEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKMEAykvlsKKTKKGQPNLNAQMEFLLQK 200
Cdd:PRK05035  439 RAIEQ-EKKKAEEAKARFEARQARLEREKAAREARHKKAAE-----ARAAKDKDAVAAALARVKAK 498
PTZ00121 PTZ00121
MAEBL; Provisional
 94-195 7.50e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 37.04  E-value: 7.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024439333   94 EERLKKQHKSPNHSVLSEERLNKAVEPVTTEGKFKKKTSNQKAKEEYEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKM 173
Cdd:PTZ00121  1287 EEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA 1366

                           90       100
                   ....*....|....*....|..
gi 2024439333  174 EAYKVLSKKTKKGQPNLNAQME 195
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAE 1388
PTZ00121 PTZ00121
MAEBL; Provisional
 51-204 8.14e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 36.66  E-value: 8.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024439333   51 RRKQKIERKYRKLLKKEQKICSPQADQFTDTYPEHLK---HLYLAEEERLKKQHKSPNhsvlSEERLNKAVEPVTTEGKF 127
Cdd:PTZ00121  1639 KKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKkaeEAKKAEEDEKKAAEALKK----EAEEAKKAEELKKKEAEE 1714

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024439333  128 KKKTSNQKAKEEYEKIQAERAKKREEAEKRRQQKEAAQRLYKQKKMEAYKVLSKKTKKGQPNLNAQMEFLLQKIQQK 204
Cdd:PTZ00121  1715 KKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEK 1791
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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