laminin subunit beta-4 isoform X2 [Gallus gallus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| Laminin_N | pfam00055 | Laminin N-terminal (Domain VI); |
31-266 | 1.41e-100 | |||||
Laminin N-terminal (Domain VI); : Pssm-ID: 459653 Cd Length: 230 Bit Score: 322.22 E-value: 1.41e-100
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| cc_LAMB_C super family | cl40438 | C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family; The LAMB family ... |
1704-1773 | 1.14e-24 | |||||
C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family; The LAMB family contains four members, LAMB1-4. They are components of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. This model corresponds to the C-terminal coiled-coil domain of LAMB, which may be involved in the integrin binding activity. The actual alignment was detected with superfamily member cd22301: Pssm-ID: 424069 [Multi-domain] Cd Length: 70 Bit Score: 98.58 E-value: 1.14e-24
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
866-914 | 7.34e-14 | |||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. : Pssm-ID: 395007 Cd Length: 49 Bit Score: 67.38 E-value: 7.34e-14
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1129-1174 | 1.24e-11 | |||||
Laminin-type epidermal growth factor-like domai; : Pssm-ID: 214543 Cd Length: 46 Bit Score: 60.79 E-value: 1.24e-11
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
457-506 | 5.18e-11 | |||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies : Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.29 E-value: 5.18e-11
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
508-551 | 1.58e-10 | |||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies : Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.75 E-value: 1.58e-10
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1071-1127 | 2.54e-10 | |||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. : Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.36 E-value: 2.54e-10
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
818-863 | 2.84e-10 | |||||
Laminin-type epidermal growth factor-like domai; : Pssm-ID: 214543 Cd Length: 46 Bit Score: 56.94 E-value: 2.84e-10
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1177-1221 | 7.93e-10 | |||||
Laminin-type epidermal growth factor-like domai; : Pssm-ID: 214543 Cd Length: 46 Bit Score: 55.78 E-value: 7.93e-10
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
398-455 | 1.80e-09 | |||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. : Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.05 E-value: 1.80e-09
|
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| Mplasa_alph_rch super family | cl37461 | helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1502-1769 | 1.41e-08 | |||||
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown. The actual alignment was detected with superfamily member TIGR04523: Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 59.65 E-value: 1.41e-08
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
911-958 | 4.84e-08 | |||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies : Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.82 E-value: 4.84e-08
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1018-1069 | 3.47e-07 | |||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies : Pssm-ID: 238012 Cd Length: 50 Bit Score: 48.50 E-value: 3.47e-07
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
268-323 | 7.76e-07 | |||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies : Pssm-ID: 238012 Cd Length: 50 Bit Score: 47.35 E-value: 7.76e-07
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
335-386 | 6.18e-06 | |||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. : Pssm-ID: 395007 Cd Length: 49 Bit Score: 45.04 E-value: 6.18e-06
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
960-1016 | 6.99e-04 | |||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. : Pssm-ID: 395007 Cd Length: 49 Bit Score: 39.26 E-value: 6.99e-04
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| Name | Accession | Description | Interval | E-value | ||||||
| Laminin_N | pfam00055 | Laminin N-terminal (Domain VI); |
31-266 | 1.41e-100 | ||||||
Laminin N-terminal (Domain VI); Pssm-ID: 459653 Cd Length: 230 Bit Score: 322.22 E-value: 1.41e-100
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| LamNT | smart00136 | Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
26-266 | 1.21e-69 | ||||||
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins. Pssm-ID: 214532 Cd Length: 238 Bit Score: 234.18 E-value: 1.21e-69
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| cc_LAMB4_C | cd22301 | C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called ... |
1704-1773 | 1.14e-24 | ||||||
C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called laminin beta-1-related protein, is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Mutations or loss of LAMB4 may be features of gastric and colorectal cancers. Reduced LAMB4 levels may contribute to colonic dysmotility associated with diverticulitis. This model corresponds to the C-terminal coiled-coil domain of LAMB4, which may be involved in the integrin binding activity. Pssm-ID: 411972 [Multi-domain] Cd Length: 70 Bit Score: 98.58 E-value: 1.14e-24
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
866-914 | 7.34e-14 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 67.38 E-value: 7.34e-14
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
865-907 | 3.23e-12 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 62.76 E-value: 3.23e-12
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1129-1174 | 1.24e-11 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 60.79 E-value: 1.24e-11
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1129-1177 | 1.45e-11 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.83 E-value: 1.45e-11
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
457-506 | 5.18e-11 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.29 E-value: 5.18e-11
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
866-909 | 5.77e-11 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 58.86 E-value: 5.77e-11
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
508-551 | 1.58e-10 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.75 E-value: 1.58e-10
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1129-1172 | 1.72e-10 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.75 E-value: 1.72e-10
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1071-1127 | 2.54e-10 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.36 E-value: 2.54e-10
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
818-863 | 2.84e-10 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 56.94 E-value: 2.84e-10
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1177-1221 | 7.93e-10 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 55.78 E-value: 7.93e-10
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1071-1127 | 8.49e-10 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 55.82 E-value: 8.49e-10
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
818-868 | 8.79e-10 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.82 E-value: 8.79e-10
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
817-862 | 1.00e-09 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 55.44 E-value: 1.00e-09
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
458-511 | 1.17e-09 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.44 E-value: 1.17e-09
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
398-455 | 1.80e-09 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.05 E-value: 1.80e-09
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1176-1214 | 6.96e-09 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 53.13 E-value: 6.96e-09
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
458-498 | 1.25e-08 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 52.31 E-value: 1.25e-08
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
509-547 | 1.27e-08 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 52.31 E-value: 1.27e-08
|
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| Mplasa_alph_rch | TIGR04523 | helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1502-1769 | 1.41e-08 | ||||||
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown. Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 59.65 E-value: 1.41e-08
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1177-1214 | 1.77e-08 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 51.97 E-value: 1.77e-08
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1071-1126 | 2.64e-08 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 51.54 E-value: 2.64e-08
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| COG4372 | COG4372 | Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1592-1771 | 2.72e-08 | ||||||
Uncharacterized protein, contains DUF3084 domain [Function unknown]; Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 57.99 E-value: 2.72e-08
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
911-958 | 4.84e-08 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.82 E-value: 4.84e-08
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
397-456 | 1.35e-07 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 49.66 E-value: 1.35e-07
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1018-1069 | 3.47e-07 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 48.50 E-value: 3.47e-07
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
509-552 | 5.02e-07 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 48.12 E-value: 5.02e-07
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
268-323 | 7.76e-07 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 47.35 E-value: 7.76e-07
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1019-1061 | 8.43e-07 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 47.35 E-value: 8.43e-07
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
398-455 | 1.21e-06 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 46.92 E-value: 1.21e-06
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
335-386 | 6.18e-06 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 45.04 E-value: 6.18e-06
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
334-388 | 1.12e-05 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 44.27 E-value: 1.12e-05
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1021-1062 | 1.57e-04 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.76 E-value: 1.57e-04
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
268-326 | 2.97e-04 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 40.03 E-value: 2.97e-04
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
912-951 | 4.25e-04 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.60 E-value: 4.25e-04
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
960-1016 | 6.99e-04 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 39.26 E-value: 6.99e-04
|
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| OmpH | pfam03938 | Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ... |
1669-1771 | 9.54e-04 | ||||||
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery. Pssm-ID: 461098 [Multi-domain] Cd Length: 140 Bit Score: 41.41 E-value: 9.54e-04
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| PRK03918 | PRK03918 | DNA double-strand break repair ATPase Rad50; |
1464-1771 | 1.01e-03 | ||||||
DNA double-strand break repair ATPase Rad50; Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 43.90 E-value: 1.01e-03
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| Spc7 | smart00787 | Spc7 kinetochore protein; This domain is found in cell division proteins which are required ... |
1471-1774 | 1.25e-03 | ||||||
Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association. Pssm-ID: 197874 [Multi-domain] Cd Length: 312 Bit Score: 43.08 E-value: 1.25e-03
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| ClyA-like | cd21116 | family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ... |
1583-1696 | 1.28e-03 | ||||||
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA). Pssm-ID: 439149 [Multi-domain] Cd Length: 224 Bit Score: 42.40 E-value: 1.28e-03
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
282-321 | 1.72e-03 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 38.06 E-value: 1.72e-03
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| SCP-1 | pfam05483 | Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
1459-1760 | 2.28e-03 | ||||||
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase. Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 42.79 E-value: 2.28e-03
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
335-385 | 2.57e-03 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 37.29 E-value: 2.57e-03
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| TNFRSF4 | cd13406 | Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; ... |
921-1006 | 4.85e-03 | ||||||
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; TNFRSF4 (also known as OX40, ACT35, CD134, IMD16, TXGP1L) activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus. Pssm-ID: 276911 [Multi-domain] Cd Length: 142 Bit Score: 39.30 E-value: 4.85e-03
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| Name | Accession | Description | Interval | E-value | ||||||
| Laminin_N | pfam00055 | Laminin N-terminal (Domain VI); |
31-266 | 1.41e-100 | ||||||
Laminin N-terminal (Domain VI); Pssm-ID: 459653 Cd Length: 230 Bit Score: 322.22 E-value: 1.41e-100
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| LamNT | smart00136 | Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
26-266 | 1.21e-69 | ||||||
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins. Pssm-ID: 214532 Cd Length: 238 Bit Score: 234.18 E-value: 1.21e-69
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| cc_LAMB4_C | cd22301 | C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called ... |
1704-1773 | 1.14e-24 | ||||||
C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called laminin beta-1-related protein, is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Mutations or loss of LAMB4 may be features of gastric and colorectal cancers. Reduced LAMB4 levels may contribute to colonic dysmotility associated with diverticulitis. This model corresponds to the C-terminal coiled-coil domain of LAMB4, which may be involved in the integrin binding activity. Pssm-ID: 411972 [Multi-domain] Cd Length: 70 Bit Score: 98.58 E-value: 1.14e-24
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| cc_LAMB_C | cd22295 | C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family; The LAMB family ... |
1704-1773 | 4.11e-15 | ||||||
C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family; The LAMB family contains four members, LAMB1-4. They are components of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. This model corresponds to the C-terminal coiled-coil domain of LAMB, which may be involved in the integrin binding activity. Pssm-ID: 411969 [Multi-domain] Cd Length: 70 Bit Score: 71.54 E-value: 4.11e-15
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
866-914 | 7.34e-14 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 67.38 E-value: 7.34e-14
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
865-907 | 3.23e-12 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 62.76 E-value: 3.23e-12
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1129-1174 | 1.24e-11 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 60.79 E-value: 1.24e-11
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1129-1177 | 1.45e-11 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.83 E-value: 1.45e-11
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
457-506 | 5.18e-11 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.29 E-value: 5.18e-11
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
866-909 | 5.77e-11 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 58.86 E-value: 5.77e-11
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
508-551 | 1.58e-10 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.75 E-value: 1.58e-10
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1129-1172 | 1.72e-10 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.75 E-value: 1.72e-10
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1071-1127 | 2.54e-10 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.36 E-value: 2.54e-10
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
818-863 | 2.84e-10 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 56.94 E-value: 2.84e-10
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1177-1221 | 7.93e-10 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 55.78 E-value: 7.93e-10
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1071-1127 | 8.49e-10 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 55.82 E-value: 8.49e-10
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
818-868 | 8.79e-10 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.82 E-value: 8.79e-10
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
817-862 | 1.00e-09 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 55.44 E-value: 1.00e-09
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
458-511 | 1.17e-09 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.44 E-value: 1.17e-09
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
398-455 | 1.80e-09 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.05 E-value: 1.80e-09
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1176-1214 | 6.96e-09 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 53.13 E-value: 6.96e-09
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
458-498 | 1.25e-08 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 52.31 E-value: 1.25e-08
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
509-547 | 1.27e-08 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 52.31 E-value: 1.27e-08
|
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| Mplasa_alph_rch | TIGR04523 | helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1502-1769 | 1.41e-08 | ||||||
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown. Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 59.65 E-value: 1.41e-08
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1177-1214 | 1.77e-08 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 51.97 E-value: 1.77e-08
|
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| Mplasa_alph_rch | TIGR04523 | helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1465-1775 | 1.80e-08 | ||||||
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown. Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 59.65 E-value: 1.80e-08
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1071-1126 | 2.64e-08 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 51.54 E-value: 2.64e-08
|
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| COG4372 | COG4372 | Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1592-1771 | 2.72e-08 | ||||||
Uncharacterized protein, contains DUF3084 domain [Function unknown]; Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 57.99 E-value: 2.72e-08
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
911-958 | 4.84e-08 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.82 E-value: 4.84e-08
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
397-456 | 1.35e-07 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 49.66 E-value: 1.35e-07
|
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| Mplasa_alph_rch | TIGR04523 | helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1499-1768 | 1.67e-07 | ||||||
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown. Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 56.18 E-value: 1.67e-07
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1018-1069 | 3.47e-07 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 48.50 E-value: 3.47e-07
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
509-552 | 5.02e-07 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 48.12 E-value: 5.02e-07
|
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| GumC | COG3206 | Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
1591-1772 | 5.23e-07 | ||||||
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 54.64 E-value: 5.23e-07
|
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
268-323 | 7.76e-07 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 47.35 E-value: 7.76e-07
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1019-1061 | 8.43e-07 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 47.35 E-value: 8.43e-07
|
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
398-455 | 1.21e-06 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 46.92 E-value: 1.21e-06
|
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| COG1340 | COG1340 | Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
1555-1765 | 1.70e-06 | ||||||
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 51.84 E-value: 1.70e-06
|
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| DR0291 | COG1579 | Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
1598-1769 | 5.54e-06 | ||||||
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only]; Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 49.54 E-value: 5.54e-06
|
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
335-386 | 6.18e-06 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 45.04 E-value: 6.18e-06
|
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| COG4372 | COG4372 | Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1555-1767 | 6.77e-06 | ||||||
Uncharacterized protein, contains DUF3084 domain [Function unknown]; Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 50.29 E-value: 6.77e-06
|
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| cc_LAMB1_C | cd22300 | C-terminal coiled-coil domain found in laminin subunit beta-1 (LAMB1); LAMB1 is also called ... |
1723-1773 | 7.54e-06 | ||||||
C-terminal coiled-coil domain found in laminin subunit beta-1 (LAMB1); LAMB1 is also called laminin B1 chain, laminin-1 subunit beta, laminin-10 subunit beta, laminin-12 subunit beta, laminin-2 subunit beta, laminin-6 subunit beta, or laminin-8 subunit beta. It is a glycoprotein that is involved in the pathogenesis of neurodevelopmental disorders. It also plays a crucial role in both lung morphogenesis and physiological function. Mutations in LAMB1 are associated with Cobblestone brain malformation (COB) with variable muscular or ocular abnormalities. LAMB1 is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. This model corresponds to the C-terminal coiled-coil domain of LAMB1, which is involved in the integrin binding activity. Pssm-ID: 411971 [Multi-domain] Cd Length: 73 Bit Score: 45.54 E-value: 7.54e-06
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
334-388 | 1.12e-05 | ||||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 44.27 E-value: 1.12e-05
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| CwlO1 | COG3883 | Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
1575-1768 | 1.14e-05 | ||||||
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown]; Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 49.83 E-value: 1.14e-05
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| SMC_prok_B | TIGR02168 | chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1502-1765 | 2.10e-05 | ||||||
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 49.67 E-value: 2.10e-05
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| Mplasa_alph_rch | TIGR04523 | helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1465-1771 | 4.41e-05 | ||||||
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown. Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 48.48 E-value: 4.41e-05
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| SMC_prok_B | TIGR02168 | chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1572-1767 | 4.77e-05 | ||||||
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 48.51 E-value: 4.77e-05
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| YhaN | COG4717 | Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
1582-1770 | 6.89e-05 | ||||||
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 47.84 E-value: 6.89e-05
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| EnvC | COG4942 | Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1555-1769 | 7.27e-05 | ||||||
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 47.07 E-value: 7.27e-05
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| COG1340 | COG1340 | Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
1466-1736 | 7.67e-05 | ||||||
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 46.83 E-value: 7.67e-05
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| COG4372 | COG4372 | Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1582-1771 | 1.26e-04 | ||||||
Uncharacterized protein, contains DUF3084 domain [Function unknown]; Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 46.43 E-value: 1.26e-04
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| cc_LAMB3_C | cd22303 | C-terminal coiled-coil domain found in laminin subunit beta-3 (LAMB3); LAMB3 is also called ... |
1704-1774 | 1.56e-04 | ||||||
C-terminal coiled-coil domain found in laminin subunit beta-3 (LAMB3); LAMB3 is also called epiligrin subunit beta, kalinin B1 chain, kalinin subunit beta, laminin B1k chain, laminin-5 subunit beta, or nicein subunit beta. It is a major component of the basement membrane in most adult tissues. Mutations in LAMB3 are associated with Herlitz junctional epidermolysis bullosa (H-JEB), a severe autosomal recessive disorder characterized by blister formation within the dermal-epidermal basement membrane. LAMB3 is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. This model corresponds to the C-terminal coiled-coil domain of LAMB3, which may be involved in the integrin binding activity. Pssm-ID: 411974 [Multi-domain] Cd Length: 71 Bit Score: 41.66 E-value: 1.56e-04
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1021-1062 | 1.57e-04 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.76 E-value: 1.57e-04
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| SMC_prok_A | TIGR02169 | chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
1588-1769 | 1.63e-04 | ||||||
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 46.60 E-value: 1.63e-04
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| SMC_prok_A | TIGR02169 | chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
1501-1769 | 1.75e-04 | ||||||
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 46.60 E-value: 1.75e-04
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| SMC_prok_B | TIGR02168 | chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1583-1769 | 2.20e-04 | ||||||
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 46.20 E-value: 2.20e-04
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
268-326 | 2.97e-04 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 40.03 E-value: 2.97e-04
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| SMC_prok_A | TIGR02169 | chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
1483-1767 | 3.92e-04 | ||||||
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 45.44 E-value: 3.92e-04
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
912-951 | 4.25e-04 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.60 E-value: 4.25e-04
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| cc_LAMB2_C | cd22299 | C-terminal coiled-coil domain found in laminin subunit beta-2 (LAMB2); LAMB2 is also called ... |
1724-1774 | 5.97e-04 | ||||||
C-terminal coiled-coil domain found in laminin subunit beta-2 (LAMB2); LAMB2 is also called laminin B1s chain, laminin-11 subunit beta, laminin-14 subunit beta, laminin-15 subunit beta, laminin-3 subunit beta, laminin-4 subunit beta, laminin-7 subunit beta, laminin-9 subunit beta, S-laminin subunit beta, or S-LAM beta (LAMS). It is an important component of the interphotoreceptor matrix and plays a role in rod morphogenesis. It may also have an important function in the sarcolemmal basement membrane. Mutations of the LAMB2 gene mainly cause Pierson syndrome (microcoria-congenital nephrosis syndrome). LAMB2 is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. This model corresponds to the C-terminal coiled-coil domain of LAMB2, which may be involved in the integrin binding activity. Pssm-ID: 411970 [Multi-domain] Cd Length: 72 Bit Score: 40.12 E-value: 5.97e-04
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
960-1016 | 6.99e-04 | ||||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 39.26 E-value: 6.99e-04
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| bZIP_Jun | cd14696 | Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and ... |
1723-1765 | 9.33e-04 | ||||||
Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain; Jun is a member of the activator protein-1 (AP-1) complex, which is mainly composed of Basic leucine zipper (bZIP) dimers of the Jun and Fos families, and to a lesser extent, the activating transcription factor (ATF) and musculoaponeurotic fibrosarcoma (Maf) families. The broad combinatorial possibilities for various dimers determine binding specificity, affinity, and the spectrum of regulated genes. The AP-1 complex is implicated in many cell functions including proliferation, apoptosis, survival, migration, tumorigenesis, and morphogenesis, among others. There are three Jun proteins: c-Jun, JunB, and JunD. c-Jun is the most potent transcriptional activator of the AP-1 proteins. Both c-Jun and JunB are essential during development; deletion of either results in embryonic lethality in mice. c-Jun is essential in hepatogenesis and liver erythropoiesis, while JunB is required in vasculogenesis and angiogenesis in extraembryonic tissues. While JunD is dispensable in embryonic development, it is involved in transcription regulation of target genes that help cells to cope with environmental signals. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription. Pssm-ID: 269844 [Multi-domain] Cd Length: 61 Bit Score: 39.10 E-value: 9.33e-04
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| OmpH | pfam03938 | Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ... |
1669-1771 | 9.54e-04 | ||||||
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery. Pssm-ID: 461098 [Multi-domain] Cd Length: 140 Bit Score: 41.41 E-value: 9.54e-04
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| PRK03918 | PRK03918 | DNA double-strand break repair ATPase Rad50; |
1464-1771 | 1.01e-03 | ||||||
DNA double-strand break repair ATPase Rad50; Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 43.90 E-value: 1.01e-03
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| Spc7 | smart00787 | Spc7 kinetochore protein; This domain is found in cell division proteins which are required ... |
1471-1774 | 1.25e-03 | ||||||
Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association. Pssm-ID: 197874 [Multi-domain] Cd Length: 312 Bit Score: 43.08 E-value: 1.25e-03
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| ClyA-like | cd21116 | family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ... |
1583-1696 | 1.28e-03 | ||||||
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA). Pssm-ID: 439149 [Multi-domain] Cd Length: 224 Bit Score: 42.40 E-value: 1.28e-03
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| Mplasa_alph_rch | TIGR04523 | helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1556-1775 | 1.44e-03 | ||||||
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown. Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 43.47 E-value: 1.44e-03
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
282-321 | 1.72e-03 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 38.06 E-value: 1.72e-03
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| SCP-1 | pfam05483 | Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
1459-1760 | 2.28e-03 | ||||||
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase. Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 42.79 E-value: 2.28e-03
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
335-385 | 2.57e-03 | ||||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 37.29 E-value: 2.57e-03
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| Myosin_tail_1 | pfam01576 | Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
1588-1767 | 4.53e-03 | ||||||
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament. Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 42.08 E-value: 4.53e-03
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| COG1340 | COG1340 | Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
1600-1765 | 4.61e-03 | ||||||
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 41.05 E-value: 4.61e-03
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| TNFRSF4 | cd13406 | Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; ... |
921-1006 | 4.85e-03 | ||||||
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; TNFRSF4 (also known as OX40, ACT35, CD134, IMD16, TXGP1L) activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus. Pssm-ID: 276911 [Multi-domain] Cd Length: 142 Bit Score: 39.30 E-value: 4.85e-03
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| SMC_prok_A | TIGR02169 | chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
1555-1774 | 5.46e-03 | ||||||
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 41.59 E-value: 5.46e-03
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| VSP | pfam03302 | Giardia variant-specific surface protein; |
940-1239 | 5.90e-03 | ||||||
Giardia variant-specific surface protein; Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 41.11 E-value: 5.90e-03
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| PRK03918 | PRK03918 | DNA double-strand break repair ATPase Rad50; |
1503-1765 | 8.21e-03 | ||||||
DNA double-strand break repair ATPase Rad50; Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 41.20 E-value: 8.21e-03
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| Smc | COG1196 | Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
1555-1768 | 8.57e-03 | ||||||
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 41.08 E-value: 8.57e-03
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