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Conserved domains on  [gi|2024446446|ref|XP_040517033|]
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collectrin isoform X1 [Gallus gallus]

Protein Classification

Collectrin domain-containing protein( domain architecture ID 11246542)

Collectrin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Collectrin pfam16959
Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is ...
 27-175 1.97e-93

Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is homologous to the C-terminal region of human angiotensin-converting enzyme 2, ACE2, SwissProt:Q9BYF1, found in Peptidase_M2 pfam01401. Collectrin is critical for normal amino acid reabsorption in the kidney.


:

Pssm-ID: 465322  Cd Length: 154  Bit Score: 270.28  E-value: 1.97e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024446446  27 AFKVRLSIKTALGDNAYAWDANEEYLFKAMIAFTMRRYSSKSTTQ-----ISNVLLCNVTDRVSFWFVVTDSSKNTTTVP 101
Cdd:pfam16959   1 AIKVRISLKTALGDKAYEWNENEMYLFKASVAYAMRKYFSREKNQtvpfqIENVLVCNETPRVSFWFVVTSPNNPSDLIP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024446446 102 GSEVEAAIRMNRNRINSAFLLSDKTLQFLKISTTLSPPVEPSTPVWLIVFGVVLSLIVAGIVFLVVSGIQQRKK 175
Cdd:pfam16959  81 KAEVEAAIRMSRNRINNAFLLDDSTLEFLGIPPTLAPPVEPPVPIWLIVFGVVMGLVVVGIVYLIVSGIRQRRR 154
 
Name Accession Description Interval E-value
Collectrin pfam16959
Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is ...
 27-175 1.97e-93

Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is homologous to the C-terminal region of human angiotensin-converting enzyme 2, ACE2, SwissProt:Q9BYF1, found in Peptidase_M2 pfam01401. Collectrin is critical for normal amino acid reabsorption in the kidney.


Pssm-ID: 465322  Cd Length: 154  Bit Score: 270.28  E-value: 1.97e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024446446  27 AFKVRLSIKTALGDNAYAWDANEEYLFKAMIAFTMRRYSSKSTTQ-----ISNVLLCNVTDRVSFWFVVTDSSKNTTTVP 101
Cdd:pfam16959   1 AIKVRISLKTALGDKAYEWNENEMYLFKASVAYAMRKYFSREKNQtvpfqIENVLVCNETPRVSFWFVVTSPNNPSDLIP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024446446 102 GSEVEAAIRMNRNRINSAFLLSDKTLQFLKISTTLSPPVEPSTPVWLIVFGVVLSLIVAGIVFLVVSGIQQRKK 175
Cdd:pfam16959  81 KAEVEAAIRMSRNRINNAFLLDDSTLEFLGIPPTLAPPVEPPVPIWLIVFGVVMGLVVVGIVYLIVSGIRQRRR 154
JMTM_dNotch cd21706
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ...
 127-176 7.53e-03

juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411989  Cd Length: 90  Bit Score: 34.54  E-value: 7.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2024446446 127 LQFLKISTTLSP---PVEPSTPVWLIVFGVVLSLIVAGIVFLVVSgiQQRKKK 176
Cdd:cd21706     2 FPIYQVRGEDPPdppPEPPPSNLTYVVIGVVVVLLIGLLLGVLVT--TQRKRA 52
 
Name Accession Description Interval E-value
Collectrin pfam16959
Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is ...
 27-175 1.97e-93

Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is homologous to the C-terminal region of human angiotensin-converting enzyme 2, ACE2, SwissProt:Q9BYF1, found in Peptidase_M2 pfam01401. Collectrin is critical for normal amino acid reabsorption in the kidney.


Pssm-ID: 465322  Cd Length: 154  Bit Score: 270.28  E-value: 1.97e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024446446  27 AFKVRLSIKTALGDNAYAWDANEEYLFKAMIAFTMRRYSSKSTTQ-----ISNVLLCNVTDRVSFWFVVTDSSKNTTTVP 101
Cdd:pfam16959   1 AIKVRISLKTALGDKAYEWNENEMYLFKASVAYAMRKYFSREKNQtvpfqIENVLVCNETPRVSFWFVVTSPNNPSDLIP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024446446 102 GSEVEAAIRMNRNRINSAFLLSDKTLQFLKISTTLSPPVEPSTPVWLIVFGVVLSLIVAGIVFLVVSGIQQRKK 175
Cdd:pfam16959  81 KAEVEAAIRMSRNRINNAFLLDDSTLEFLGIPPTLAPPVEPPVPIWLIVFGVVMGLVVVGIVYLIVSGIRQRRR 154
JMTM_dNotch cd21706
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ...
 127-176 7.53e-03

juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411989  Cd Length: 90  Bit Score: 34.54  E-value: 7.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2024446446 127 LQFLKISTTLSP---PVEPSTPVWLIVFGVVLSLIVAGIVFLVVSgiQQRKKK 176
Cdd:cd21706     2 FPIYQVRGEDPPdppPEPPPSNLTYVVIGVVVVLLIGLLLGVLVT--TQRKRA 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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