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Conserved domains on  [gi|2024343466|ref|XP_040518343|]
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rho GTPase-activating protein 6 isoform X6 [Gallus gallus]

Protein Classification

rho GTPase-activating 6 family protein( domain architecture ID 10138145)

rho GTPase-activating 6 family protein (RhoGAP6-like) such as RhoGAP6, also known as ArhGAP6, which is both a GTPase-activating protein (GAP) with specificity for RhoA and a cytoskeletal protein that promotes actin remodelling, and RhoGAP36 (ArhGAP36) which is a potent antagonist of PKA signaling

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 199-405 5.01e-133

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239841  Cd Length: 206  Bit Score: 392.96  E-value: 5.01e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 199 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLL 278
Cdd:cd04376     1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 279 TRELYTPFINTLLLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDTTDKDGQEVTGNKMTSLNLATIFGPN 358
Cdd:cd04376    81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2024343466 359 LLHKQKSTDKEFtVQSSARAEESTAIIAVVQKMIENYEALFMVSPDL 405
Cdd:cd04376   161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 199-405 5.01e-133

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 392.96  E-value: 5.01e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 199 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLL 278
Cdd:cd04376     1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 279 TRELYTPFINTLLLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDTTDKDGQEVTGNKMTSLNLATIFGPN 358
Cdd:cd04376    81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2024343466 359 LLHKQKSTDKEFtVQSSARAEESTAIIAVVQKMIENYEALFMVSPDL 405
Cdd:cd04376   161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 205-395 7.05e-57

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 192.10  E-value: 7.05e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466  205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLD-EEHSIHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466  284 TPFINTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEdttdkdgqevtGNKMTSLNLATIFGPNLLHK 362
Cdd:smart00324  81 EEFIEAAKLEdETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLLRP 149

                          170       180       190
                   ....*....|....*....|....*....|...
gi 2024343466  363 QKSTdkeftvqsSARAEESTAIIAVVQKMIENY 395
Cdd:smart00324 150 PDGE--------VASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 208-361 6.25e-56

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 188.52  E-value: 6.25e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 208 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLD-EEHSIHDVAALLKEFLRDMPDPLLTRELYTPF 286
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024343466 287 INTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLH 361
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 199-405 5.01e-133

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 392.96  E-value: 5.01e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 199 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLL 278
Cdd:cd04376     1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 279 TRELYTPFINTLLLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDTTDKDGQEVTGNKMTSLNLATIFGPN 358
Cdd:cd04376    81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2024343466 359 LLHKQKSTDKEFtVQSSARAEESTAIIAVVQKMIENYEALFMVSPDL 405
Cdd:cd04376   161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 205-395 7.05e-57

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 192.10  E-value: 7.05e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466  205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLD-EEHSIHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466  284 TPFINTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEdttdkdgqevtGNKMTSLNLATIFGPNLLHK 362
Cdd:smart00324  81 EEFIEAAKLEdETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLLRP 149

                          170       180       190
                   ....*....|....*....|....*....|...
gi 2024343466  363 QKSTdkeftvqsSARAEESTAIIAVVQKMIENY 395
Cdd:smart00324 150 PDGE--------VASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 208-361 6.25e-56

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 188.52  E-value: 6.25e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 208 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLD-EEHSIHDVAALLKEFLRDMPDPLLTRELYTPF 286
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024343466 287 INTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLH 361
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 208-394 8.39e-55

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 186.35  E-value: 8.39e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 208 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYTPFI 287
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 288 NTL-LLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLHKQKST 366
Cdd:cd00159    81 ELAkIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEV-----------NKMTASNLAIVFAPTLLRPPDSD 149

                         170       180
                  ....*....|....*....|....*...
gi 2024343466 367 DKEFtvqssaraEESTAIIAVVQKMIEN 394
Cdd:cd00159   150 DELL--------EDIKKLNEIVEFLIEN 169
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 207-395 2.74e-34

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 129.35  E-value: 2.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR-GIDVVLDE-EHSIHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04385    15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKdARSVQLREgEYTVHDVADVLKRFLRDLPDPLLTSELHA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 285 PFINTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLHkq 363
Cdd:cd04385    95 EWIEAAELEnKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDE-----------NQMSVHNLALVFGPTLFQ-- 161

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2024343466 364 ksTDKEFTVQSSaraEEstaiIAVVQKMIENY 395
Cdd:cd04385   162 --TDEHSVGQTS---HE----VKVIEDLIDNY 184
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-409 2.61e-33

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 127.46  E-value: 2.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR--GIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04391    22 VPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAkfYEGTFLWDQVKQHDAASLLKLFIRELPQPLLTVEYLP 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 285 PFINTLLL-EPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNL---- 359
Cdd:cd04391   102 AFYSVQGLpSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEK-----------NKMNLWNVAMIMAPNLfppr 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2024343466 360 -LHKQKSTDKEFTVQSSARAEEstaiiaVVQKMIENYEALFMVSPDLQNEV 409
Cdd:cd04391   171 gKHSKDNESLQEEVNMAAGCAN------IMRLLIRYQDLLWTVPSFLINQV 215
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 201-399 1.08e-32

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 125.14  E-value: 1.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 201 NPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTR 280
Cdd:cd04404    17 NPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTFLRELPEPLLTF 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 281 ELYTPFINTLLLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLL 360
Cdd:cd04404    97 DLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ-----------NKMTNSNLAVVFGPNLL 165

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2024343466 361 HKQKstdkeftvqSSARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04404   166 WAKD---------ASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 205-377 1.66e-32

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 124.47  E-value: 1.66e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04377    13 RSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHVITSVLKQWLRELPEPLMTFELYE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 285 PFINTL-LLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHaEDTtdkdgqevtgNKMTSLNLATIFGPNLLHKQ 363
Cdd:cd04377    93 NFLRAMeLEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQ-EEV----------NRMSANALAIVFAPCILRCP 161

                         170
                  ....*....|....
gi 2024343466 364 KSTDKEFTVQSSAR 377
Cdd:cd04377   162 DTADPLQSLQDVSK 175
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-359 2.19e-32

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 124.43  E-value: 2.19e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG---IDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04395    18 VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGgfdIDLQDPRWRDVNVVSSLLKSFFRKLPEPLFTNELY 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024343466 284 TPFINTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNL 359
Cdd:cd04395    98 PDFIEANRIEdPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEV-----------NKMEPRNLAIVFGPTL 163
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 183-405 5.17e-32

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 123.63  E-value: 5.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 183 PAEAQSKKEKArDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLD--EEHSIH 260
Cdd:cd04397     4 PLEILVEKFGA-DSTLGVGPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDlsKENPVQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 261 dVAALLKEFLRDMPDPLLTRELYTPFINTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEdtTDkdgq 339
Cdd:cd04397    83 -LAALLKKFLRELPDPLLTFKLYRLWISSQKIEdEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSH--ID---- 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024343466 340 EVTGNKMTSLNLATIFGPNLLHKQKSTDKEftvqssarAEESTAIIAVVQKMIENYEALFMVSPDL 405
Cdd:cd04397   156 EETGSKMDIHNLATVITPNILYSKTDNPNT--------GDEYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-405 3.41e-30

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 118.67  E-value: 3.41e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYTPF 286
Cdd:cd04375    20 LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLKQYFRDLPEPLLTNKLSETF 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 287 INTLLLEPDEQ-LSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHaedttdkdgqeVTGNKMTSLNLATIFGPNLLHKQKS 365
Cdd:cd04375   100 IAIFQYVPKEQrLEAVQCAILLLPDENREVLQTLLYFLSDVAAN-----------SQENQMTATNLAVCLAPSLFHLNTS 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2024343466 366 TDKEFTVQSSARAEESTAIIAvvQK--------------MIENYEALFMVSPDL 405
Cdd:cd04375   169 RRENSSPARRMQRKKSLGKPD--QKelsenkaahqclayMIEECNTLFMVPKEM 220
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 202-394 8.16e-30

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 117.19  E-value: 8.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 202 PIYRQVPRLVDSCCQHLEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVvlDEEHSIHDVAALLKEFLRDMPDPLLTRE 281
Cdd:cd04394    15 PEYGNVPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGEAC--LSSALPCDVAGLLKQFFRELPEPLLPYD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 282 LYTPFINTLLLEPD-EQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLL 360
Cdd:cd04394    92 LHEALLKAQELPTDeERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSE-----------NKMDSSNLAVIFAPNLF 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2024343466 361 HkqkSTDKEFTVQSSarAEESTAI-IAVVQKMIEN 394
Cdd:cd04394   161 Q---SEEGGEKMSSS--TEKRLRLqAAVVQTLIDN 190
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-399 6.68e-29

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 114.04  E-value: 6.68e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVL-----DEEHSIHDVAALLKEFLRDMPDPLLTRE 281
Cdd:cd04398    16 VPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLlispeDYESDIHSVASLLKLFFRELPEPLLTKA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 282 LYTPFINTLLLEPDEQLS-TLQLLIYLLPPCNCDTLHRLLQFLSTVAGHaEDTtdkdgqevtgNKMTSLNLATIFGPNLL 360
Cdd:cd04398    96 LSREFIEAAKIEDESRRRdALHGLINDLPDANYATLRALMFHLARIKEH-ESV----------NRMSVNNLAIIWGPTLM 164

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2024343466 361 HkqkstdkeftvQSSARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04398   165 N-----------AAPDNAADMSFQSRVIETLLDNAYQIF 192
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-394 7.24e-29

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 114.10  E-value: 7.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYTPF 286
Cdd:cd04393    20 VPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLFLQELPEGLIPASLQIRL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 287 INTL--LLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLHKQK 364
Cdd:cd04393   100 MQLYqdYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHE-----------NRMTAENLAAVFGPDVFHVYT 168

                         170       180       190
                  ....*....|....*....|....*....|
gi 2024343466 365 STDKEftvqssaraEESTAIIAVVQKMIEN 394
Cdd:cd04393   169 DVEDM---------KEQEICSRIMAKLLEN 189
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 205-399 2.16e-28

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 112.94  E-value: 2.16e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG-IDVVLDEEHS-IHDVAALLKEFLRDMPDPLLTREL 282
Cdd:cd04386    18 REIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtFSLPLDEFYSdPHAVASALKSYLRELPDPLLTYNL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 283 YTPFINTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAghaedttdkdgQEVTGNKMTSLNLATIFGPNLLh 361
Cdd:cd04386    98 YEDWVQAANKPdEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLA-----------QKSDENKMSPSNIAIVLAPNLL- 165

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2024343466 362 kqksTDKEFTVQSSARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04386   166 ----WAKNEGSLAEMAAGTSVHVVAIVELIISHADWFF 199
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-399 9.80e-28

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 110.85  E-value: 9.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEhSIHDVAALLKEFLRDMPDPLLTRELYTPF 286
Cdd:cd04402    15 LPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAE-PVLLLASVLKDFLRNIPGSLLSSDLYEEW 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 287 INTLLLEPDEQ-LSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLHKQks 365
Cdd:cd04402    94 MSALDQENEEEkIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSET-----------NKMDAFNLAVCIAPSLLWPP-- 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2024343466 366 tdkeftVQSSARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04402   161 ------ASSELQNEDLKKVTSLVQFLIENCQEIF 188
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 207-366 1.16e-27

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 110.56  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLR--EEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04403    16 VPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRfaVDHDEKLDLDDSKWEDIHVITGALKLFFRELPEPLFPYSLFN 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 285 PFINTLLL-EPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLHKQ 363
Cdd:cd04403    96 DFVAAIKLsDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEK-----------NRMTTQNLAIVFGPTLLRPE 164


                  ...
gi 2024343466 364 KST 366
Cdd:cd04403   165 QET 167
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 206-399 1.51e-25

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 104.52  E-value: 1.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG---IDVVLDEEHSIHDVAALLKEFLRDMPDPLLTREL 282
Cdd:cd04372    15 QRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDgekADISATVYPDINVITGALKLYFRDLPIPVITYDT 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 283 YTPFINTLLL-EPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLh 361
Cdd:cd04372    95 YPKFIDAAKIsNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKD-----------NKMNAENLGIVFGPTLM- 162

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2024343466 362 kQKSTDKEFTVQSSARAEestaiIAVVQKMIENYEALF 399
Cdd:cd04372   163 -RPPEDSALTTLNDMRYQ-----ILIVQLLITNEDVLF 194
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 205-399 3.80e-25

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 103.68  E-value: 3.80e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04390    20 RLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 285 PFIN-TLLLEPDEQLSTLQLL--IYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLh 361
Cdd:cd04390   100 DFLScAQLLSKDEEKGLGELMkqVSILPKVNYNLLSYICRFLDEVQSNSSV-----------NKMSVQNLATVFGPNIL- 167

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2024343466 362 KQKSTDKEftvqssARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04390   168 RPKVEDPA------TIMEGTPQIQQLMTVMISKHEPLF 199
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 207-374 8.36e-25

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 102.89  E-value: 8.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYTPF 286
Cdd:cd04378    16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 287 I---NTLLLEPDEQ------------LSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNL 351
Cdd:cd04378    96 IalaKEIQRDTEEDkapntpievnriIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEE-----------NKMSPNNL 164

                         170       180
                  ....*....|....*....|...
gi 2024343466 352 ATIFGPNLLhKQKSTDKEFTVQS 374
Cdd:cd04378   165 GIVFGPTLI-RPRPGDADVSLSS 186
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 207-367 3.64e-24

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 100.45  E-value: 3.64e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYTPF 286
Cdd:cd04407    15 VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLENYPIHAITGLLKQWLRELPEPLMTFAQYNDF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 287 INTLLL-EPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAgHAEDTtdkdgqevtgNKMTSLNLATIFGPNLLHKQKS 365
Cdd:cd04407    95 LRAVELpEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVA-LEEDV----------NRMSPNALAIVFAPCLLRCPDS 163


                  ..
gi 2024343466 366 TD 367
Cdd:cd04407   164 SD 165
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 203-360 1.05e-23

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 100.18  E-value: 1.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 203 IYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDV---VLDEEHSIHDVAALLKEFLRDMPDPLLT 279
Cdd:cd04396    28 VYGYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDYgksFDWDGYTVHDAASVLRRYLNNLPEPLVP 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 280 RELYTPFINTLLLEP------------------DEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqev 341
Cdd:cd04396   108 LDLYEEFRNPLRKRPrilqymkgrineplntdiDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDK--------- 178

                         170
                  ....*....|....*....
gi 2024343466 342 tgNKMTSLNLATIFGPNLL 360
Cdd:cd04396   179 --NLMTASNLAAIFQPGIL 195
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-394 8.07e-23

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 96.80  E-value: 8.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTvGIFRVGSSKKRVRQLREEFDRGIDVVLDEE---HSIHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04384    18 VPQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLRHEFDSEQIPDLTKDvyiQDIHSVSSLCKLYFRELPNPLLTYQLY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 284 TPFINTLLLEPD-EQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDTtdkdgqevtgnKMTSLNLATIFGPNLLhk 362
Cdd:cd04384    97 EKFSEAVSAASDeERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSIT-----------NMHAKNLAIVWAPNLL-- 163

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2024343466 363 qKSTDKEFTVQSSARAEESTAIIAVVQKMIEN 394
Cdd:cd04384   164 -RSKQIESACFSGTAAFMEVRIQSVVVEFILN 194
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 205-359 8.74e-23

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 96.66  E-value: 8.74e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 205 RQVPRLVDSCCQHLEKHG-LQTVGIFRVGSSKKRVRQLREEFDRGIDVVL---DEEHSIHDVAALLKEFLRDMPDPLLTR 280
Cdd:cd04400    20 RDLPSVVYRCIEYLDKNRaIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfssSLYPDVHTVAGLLKLYLRELPTLILGG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 281 ELYTPF--INTLLLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHaEDTtdkdgqevtgNKMTSLNLATIFGPN 358
Cdd:cd04400   100 ELHNDFkrLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEH-SDV----------NKMNLRNVCIVFSPT 168


                  .
gi 2024343466 359 L 359
Cdd:cd04400   169 L 169
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 207-393 9.58e-23

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 96.59  E-value: 9.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYTPF 286
Cdd:cd04382    17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKEF 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 287 IN-TLLLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAghaedttdkdgqEVTGNKMTSLNLATIFGPNLL-HKQK 364
Cdd:cd04382    97 MEaAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVA------------QSPECKMDINNLARVFGPTIVgYSVP 164

                         170       180
                  ....*....|....*....|....*....
gi 2024343466 365 STDKEFTVQssaraeESTAIIAVVQKMIE 393
Cdd:cd04382   165 NPDPMTILQ------DTVRQPRVVERLLE 187
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 206-367 1.57e-22

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 96.04  E-value: 1.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYTP 285
Cdd:cd04408    15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 286 FI---NTLLLEPDEQLST----------LQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLA 352
Cdd:cd04408    95 FIalaKELQRDSEKAAESpsiveniirsLKELLGRLPVSNYNTLRHLMAHLYRVAERFED-----------NKMSPNNLG 163

                         170
                  ....*....|....*
gi 2024343466 353 TIFGPNLLHKQKSTD 367
Cdd:cd04408   164 IVFGPTLLRPLVGGD 178
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 205-393 2.33e-21

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 92.91  E-value: 2.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG-IDVVLDEEH--SIHDVAALLKEFLRDMPDPLLTRE 281
Cdd:cd04379    16 RDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNsAAVELSEELypDINVITGVLKDYLRELPEPLITPQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 282 LYTPFINTLLLEPDEQLST---LQL-LIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGP 357
Cdd:cd04379    96 LYEMVLEALAVALPNDVQTnthLTLsIIDCLPLSAKATLLLLLDHLSLVLSNSER-----------NKMTPQNLAVCFGP 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2024343466 358 NLLHKQKsTDKEFTVQSSARAEESTAI-----IAVVQKMIE 393
Cdd:cd04379   165 VLMFCSQ-EFSRYGISPTSKMAAVSTVdfkqhIEVLHYLLQ 204
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-409 3.82e-21

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 92.52  E-value: 3.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 218 LEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDE-EHSIHDVAALLKEFLRDMPDPLLTRELYTPFIN----TLLL 292
Cdd:cd04392    20 LEKN-LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESgGFHAHDCATVLKGFLGELPEPLLTHAHYPAHLQiadlCQFD 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 293 E-------PDE--QLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHaEDTtdkdgqevtgNKMTSLNLATIFGPNLLHKQ 363
Cdd:cd04392    99 EkgnktsaPDKerLLEALQLLLLLLPEENRNLLKLILDLLYQTAKH-EDK----------NKMSADNLALLFTPHLICPR 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2024343466 364 KSTdkeftvqSSARAEESTAIIAVVQKMIENYEALFMVSPDLQNEV 409
Cdd:cd04392   168 NLT-------PEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDA 206
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 207-361 9.14e-21

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 90.56  E-value: 9.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDE--EHSIHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04383    18 IPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPLADDqnDHDINSVAGVLKLYFRGLENPLFPKERFE 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024343466 285 PFINTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLH 361
Cdd:cd04383    98 DLMSCVKLEnPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDE-----------NMMDPYNLAICFGPTLMP 164
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 205-387 2.79e-20

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 89.29  E-value: 2.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04406    13 RSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 285 PFINTL-LLEPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLHKQ 363
Cdd:cd04406    93 EFLRAMgLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEET-----------NRMSANALAIVFAPCILRCP 161

                         170       180
                  ....*....|....*....|....
gi 2024343466 364 KSTDKEFTVQSSARAEESTAIIAV 387
Cdd:cd04406   162 DTTDPLQSVQDISKTTTCVELIVC 185
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 206-371 1.82e-19

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 87.29  E-value: 1.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFD---RGIDVVLdEEHSIHDVAALLKEFLRDMPDPLLTREL 282
Cdd:cd04387    15 KVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDtnnKDVSVML-SEMDVNAIAGTLKLYFRELPEPLFTDEL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 283 YTPFINTLLL-EPDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLH 361
Cdd:cd04387    94 YPNFAEGIALsDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEV-----------NKMSLHNLATVFGPTLLR 162

                         170
                  ....*....|
gi 2024343466 362 KQKSTDKEFT 371
Cdd:cd04387   163 PSEKESKIPT 172
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-374 3.66e-18

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 83.70  E-value: 3.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYTPF 286
Cdd:cd04409    16 IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLYLRQLPEPLILFRLYNEF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 287 I-------------NTLLLEPDEQLST----------LQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtg 343
Cdd:cd04409    96 IglakesqhvnetqEAKKNSDKKWPNMctelnrillkSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEE----------- 164

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2024343466 344 NKMTSLNLATIFGPNLLhKQKSTDKEFTVQS 374
Cdd:cd04409   165 NKMSASNLGIIFGPTLI-RPRPTDATVSLSS 194
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 211-394 3.96e-18

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 83.60  E-value: 3.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 211 VDSCCQHLEKHGLQTVGIFRVGSSKKRVRQL------REEFDRGiDVVLD-EEHSIHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04374    32 VRKCIEAVETRGINEQGLYRVVGVNSKVQKLlslgldPKTSTPG-DVDLDnSEWEIKTITSALKTYLRNLPEPLMTYELH 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 284 TPFINTLLLE-PDEQLSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLHK 362
Cdd:cd04374   111 NDFINAAKSEnLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKK-----------NLMTVSNLGVVFGPTLLRP 179

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2024343466 363 QkstdkeftvqssaraEESTAIIA-------VVQKMIEN 394
Cdd:cd04374   180 Q---------------EETVAAIMdikfqniVVEILIEN 203
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 206-359 1.78e-17

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 80.94  E-value: 1.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLdEEHSIHDVAALLKEFLRDMPDPLLTRELYTP 285
Cdd:cd04381    19 DLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNL-EEYEPPTVASLLKQYLRELPEPLLTKELMPR 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024343466 286 FINTL-LLEPDEQLSTLQLLIYLLPPCNcdtlHRLLQFLSTvagHAEDTTDKDGQevtgNKMTSLNLATIFGPNL 359
Cdd:cd04381    98 FEEACgRPTEAEREQELQRLLKELPECN----RLLLAWLIV---HMDHVIAQELE----TKMNIQNISIVLSPTV 161
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 205-371 5.77e-16

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 76.73  E-value: 5.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDE-EHSIHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04373    13 KPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSkDFTVNAVAGALKSFFSELPDPLIPYSMH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 284 TPFINTLLLEPDEQ-LSTLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevtgNKMTSLNLATIFGPNLLHK 362
Cdd:cd04373    93 LELVEAAKINDREQrLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKV-----------NLMTSENLSICFWPTLMRP 161


                  ....*....
gi 2024343466 363 QKSTDKEFT 371
Cdd:cd04373   162 DFTSMEALS 170
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 204-394 1.20e-13

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 70.11  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 204 YRQVPRLVDSCCQH-LEKHGLQTVGIFRVGSSKKRVRQLREEFDRGiDVVLDEEHSIHDVAALLKEFLRDMPDPLLTREL 282
Cdd:cd04389    18 ELKLPWILTFLSEKvLALGGFQTEGIFRVPGDIDEVNELKLRVDQW-DYPLSGLEDPHVPASLLKLWLRELEEPLIPDAL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 283 YTPFINTlLLEPDEQLSTLQlliyLLPPCNCDTLHRLLQFL-----STVAGHaedttdkdgqevtgNKMTSLNLATIFGP 357
Cdd:cd04389    97 YQQCISA-SEDPDKAVEIVQ----KLPIINRLVLCYLINFLqvfaqPENVAH--------------TKMDVSNLAMVFAP 157

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2024343466 358 NLLHKQkSTDKEfTVQSSARAEEStaiiaVVQKMIEN 394
Cdd:cd04389   158 NILRCT-SDDPR-VIFENTRKEMS-----FLRTLIEH 187
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 195-361 7.14e-08

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 53.88  E-value: 7.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 195 DKKLSLNPIYRQVP--------RLVDsccqHLEKHGLQTVGIFRVGS----SKKRVRQLREEFDRGIdvVLDEEHSIHDV 262
Cdd:cd04380    34 QLELGDNPDYSEVPlsipkeiwRLVD----YLYTRGLAQEGLFEEPGlpsePGELLAEIRDALDTGS--PFNSPGSAESV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 263 AALLKEFLRDMPDPLLTRELYTPFINTLLLEPDEQlstLQLLIYLLPPCNCDTLHRLLQFLSTVAGHAEDttdkdgqevt 342
Cdd:cd04380   108 AEALLLFLESLPDPIIPYSLYERLLEAVANNEEDK---RQVIRISLPPVHRNVFVYLCSFLRELLSESAD---------- 174

                         170
                  ....*....|....*....
gi 2024343466 343 gNKMTSLNLATIFGPNLLH 361
Cdd:cd04380   175 -RGLDENTLATIFGRVLLR 192
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 218-388 3.02e-04

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 42.55  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 218 LEKHGLQTVGIFRVGSSKKRVrQLREEFDRGIDVVLDEEHSIHDVAALLKEFLRDMPDPLLTRELYTPFIN--TLLLEPD 295
Cdd:cd04388    26 IEKKGLESSTLYRTQSSSSLT-ELRQILDCDAASVDLEQFDVAALADALKRYLLDLPNPVIPAPVYSEMISraQEVQSSD 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024343466 296 EQLSTLQLLIY--LLPPCNCDTLHRLLQFLSTVAghaedttdkdgQEVTGNKMTSLNLATIFGPNLLhkqkstdkEFTVQ 373
Cdd:cd04388   105 EYAQLLRKLIRspNLPHQYWLTLQYLLKHFFRLC-----------QSSSKNLLSARALAEIFSPLLF--------RFQPA 165

                         170
                  ....*....|....*
gi 2024343466 374 SSARAEESTAIIAVV 388
Cdd:cd04388   166 SSDSPEFHIRIIEVL 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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