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Conserved domains on  [gi|2024491965|ref|XP_040524416|]
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fibrocystin isoform X6 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2562-2685 3.88e-32

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 123.10  E-value: 3.88e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2562 WGGFNcsIPGPGEDVIILPNRTILVDTDLPPLRGLYILGTLEFPTNSSNVLSAACIVVVGGTLNVGSFQHPLErdSKLLV 2641
Cdd:pfam10162    2 WGGGV--VPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPFQ--GKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2024491965 2642 LLRASEgiYCDHLEEISVHPGSIGV--YGKVQIYSSYPEKSWTHLG 2685
Cdd:pfam10162   78 TLHGRP--ELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1764-1882 3.80e-25

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 103.07  E-value: 3.80e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1764 SWPSGRPPQDGANVTVEAGRTLLLGAATAALHLLHLRgGKLIFTGPGPVELHAHYILISdGGELRVGSSEARFHHRAHIY 1843
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2024491965 1844 LYGSLH--SPPLFPYGAKFLAVRN-GTLSIHGWVPKVTFTYL 1882
Cdd:pfam10162   79 LHGRPEldDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKL 120
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1032-1128 7.85e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.79  E-value: 7.85e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1032 EVFSIEPCCGSFLGGTLLTISGLGFSQNRSLVSVSINEQTCLVTRLAEETIWCLTPPATNLSNevsqdVPVRVNMLISNS 1111
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGE-----GPVEVTVDGANV 76

                           90
                   ....*....|....*..
gi 2024491965 1112 SLQNVPvakSITFNYQR 1128
Cdd:cd00603     77 SARVLS---NTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 83-136 6.22e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 58.62  E-value: 6.22e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024491965   83 EIASVFPASGSLAGGTDLTIMGDFF---EQPVRVTAAGVPCKVKRVSPRQIICTTEA 136
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPA 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1220-1284 4.33e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 56.31  E-value: 4.33e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024491965 1220 PRITSIFPSQGSICGGMLLTISGIALRARRDLGQVSLdGNYSCELQSSDNSTIKCMVLPGTHPLP 1284
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTPAAATPGE 64
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 854-937 1.10e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.07  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  854 PRLVAIEPPRASEIGGLRVALRGTGLEGVNL---VLFGSQPCPVLEdtRSSTQIECKVPSRGAEDAA---VHVTLVSGYQ 927
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVLN--VSSTEIVCRTPAAATPGEGpveVTVDGANVSA 78

                           90
                   ....*....|
gi 2024491965  928 STTVTNLFQY 937
Cdd:cd00603     79 RVLSNTTFTY 88
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1408-1477 6.92e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01179:

Pssm-ID: 472823  Cd Length: 85  Bit Score: 49.53  E-value: 6.92e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491965 1408 PQVHQFYPQNFSTNGGGLLTFAGAALKGKSRTSVLIGQHPCLILNVTCIAIQCTVPPGN--GTRALRLTVDG 1477
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAspGEAPVKVLIDG 72
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1336-1397 1.21e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.21e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491965 1336 TDVTIKGQRLAWPGDSPVVHVNDQdVCKVTFWNETIVRCQMDCIAPGDHNISISNRSGQACF 1397
Cdd:pfam01833   17 TTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISS 77
NosD super family cl34609
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2840-2993 2.67e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG3420:

Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 49.53  E-value: 2.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2840 GIKAVMSNGIWLHDNIVFNtVGPGIDLEGKNHSLVRNLIILSRQP------DGLL------NWVA---------GIKVNL 2898
Cdd:COG3420    100 GIYVRGADNAVIENNRIEN-NLFGIYLEGSDNNVIRNNTISGNRDlradrgNGIHlwnspgNVIEgntisggrdGIYLEF 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2899 VIGVSLYGNVVAGSeRVGFHIRgqecfldvdYCSE-----NVAHSNLRGIHLYRGDGfqtcTRITGFLSYKNYDYGMMF- 2972
Cdd:COG3420    179 SDNNVIRNNTIRNL-RYGIHYM---------YSNDnlvegNTFRDNGAGIALMYSKG----NTVRGNTILGNSGYGILLk 244

                          170       180
                   ....*....|....*....|.
gi 2024491965 2973 HLGSSVIIDNVVlVDNTVGLM 2993
Cdd:COG3420    245 ESSDSVIEGNTI-SGNGKGIF 264
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2112-2261 4.67e-05

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


:

Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 46.63  E-value: 4.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2112 GNRIRNNTVIGLSATdglsnietlspaGIYVR-APANHIEGNTVCAAGYGYFFHLSPERPskmpllTFSENTAHSCTRHG 2190
Cdd:pfam13229   10 NATIKNNTISNNGGY------------GIYLRgSSNATIENNTITNNGGDGIEISGSSNN------TISNNTISNNGGGG 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024491965 2191 LLVYpeylpDSPNGLVQFNSFTvWSSQGGVQIFSSSNLKLQNFQIYACTDFGIDIIESLGNTSVANSVLIG 2261
Cdd:pfam13229   72 IALR-----GSSNNLIENNTIS-NNGGAGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTN 136
PA14 super family cl08459
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 186-275 1.15e-04

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


The actual alignment was detected with superfamily member pfam07691:

Pssm-ID: 471833 [Multi-domain]  Cd Length: 141  Bit Score: 45.05  E-value: 1.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  186 LSAGKQSFSSRLRGFFVAPQTNNYTFWIQADGPASLYLSSSQDPQHkvriaslpagslewsgkWVKNWSESWQPKSQKFE 265
Cdd:pfam07691   39 FGEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWIDGELVIDN-----------------WGQHPPDASPEESNTLY 101

                           90
                   ....*....|
gi 2024491965  266 LTAGRRYYLE 275
Cdd:pfam07691  102 LVAGKLYPIR 111
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 781-844 3.26e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.05  E-value: 3.26e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024491965  781 TVVIRGVGFSEENTTLQVRVKNMTCYVVMSNQTKVVCKMERLPLGVHQLTLLVRPYGFALNAST 844
Cdd:pfam01833   18 TITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPLT 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 943-1021 2.87e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 39.35  E-value: 2.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024491965  943 PAVVSLSRNRSGLAGGQELQIGISSFANYRgSDIKVQIGGMWAQIQAQMDSGLNVTLPALAAGWYNVSVIISGVALASN 1021
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS-SDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2562-2685 3.88e-32

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 123.10  E-value: 3.88e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2562 WGGFNcsIPGPGEDVIILPNRTILVDTDLPPLRGLYILGTLEFPTNSSNVLSAACIVVVGGTLNVGSFQHPLErdSKLLV 2641
Cdd:pfam10162    2 WGGGV--VPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPFQ--GKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2024491965 2642 LLRASEgiYCDHLEEISVHPGSIGV--YGKVQIYSSYPEKSWTHLG 2685
Cdd:pfam10162   78 TLHGRP--ELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1764-1882 3.80e-25

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 103.07  E-value: 3.80e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1764 SWPSGRPPQDGANVTVEAGRTLLLGAATAALHLLHLRgGKLIFTGPGPVELHAHYILISdGGELRVGSSEARFHHRAHIY 1843
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2024491965 1844 LYGSLH--SPPLFPYGAKFLAVRN-GTLSIHGWVPKVTFTYL 1882
Cdd:pfam10162   79 LHGRPEldDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKL 120
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1032-1128 7.85e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.79  E-value: 7.85e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1032 EVFSIEPCCGSFLGGTLLTISGLGFSQNRSLVSVSINEQTCLVTRLAEETIWCLTPPATNLSNevsqdVPVRVNMLISNS 1111
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGE-----GPVEVTVDGANV 76

                           90
                   ....*....|....*..
gi 2024491965 1112 SLQNVPvakSITFNYQR 1128
Cdd:cd00603     77 SARVLS---NTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 83-136 6.22e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 58.62  E-value: 6.22e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024491965   83 EIASVFPASGSLAGGTDLTIMGDFF---EQPVRVTAAGVPCKVKRVSPRQIICTTEA 136
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPA 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1220-1284 4.33e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 56.31  E-value: 4.33e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024491965 1220 PRITSIFPSQGSICGGMLLTISGIALRARRDLGQVSLdGNYSCELQSSDNSTIKCMVLPGTHPLP 1284
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTPAAATPGE 64
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1035-1097 2.10e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 53.99  E-value: 2.10e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024491965 1035 SIEPCCGSFLGGTLLTISGLGFSQNRSLVSVSINEQTCLVTRLAEETIWCLTPPATNLSNEVS 1097
Cdd:pfam01833    5 SISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVS 67
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 854-937 1.10e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.07  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  854 PRLVAIEPPRASEIGGLRVALRGTGLEGVNL---VLFGSQPCPVLEdtRSSTQIECKVPSRGAEDAA---VHVTLVSGYQ 927
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVLN--VSSTEIVCRTPAAATPGEGpveVTVDGANVSA 78

                           90
                   ....*....|
gi 2024491965  928 STTVTNLFQY 937
Cdd:cd00603     79 RVLSNTTFTY 88
IPT smart00429
ig-like, plexins, transcription factors;
83-140 6.38e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.11  E-value: 6.38e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491965    83 EIASVFPASGSLAGGTDLTIMGDFF----EQPVRVTAAGVPCKVKRVSPRQIICTTEAVDRS 140
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLksisVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNI 64
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1408-1477 6.92e-07

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 49.53  E-value: 6.92e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491965 1408 PQVHQFYPQNFSTNGGGLLTFAGAALKGKSRTSVLIGQHPCLILNVTCIAIQCTVPPGN--GTRALRLTVDG 1477
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAspGEAPVKVLIDG 72
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1220-1280 4.12e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.44  E-value: 4.12e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024491965 1220 PRITSIFPSQGSICGGMLLTISGIALRARRDLGQVSLdGNYSCELQSSDNSTIKCMVLPGT 1280
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTI-GGTPCTVISVSSTTIVCTTPPGT 60
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 854-937 8.57e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.67  E-value: 8.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  854 PRLVAIEPPRASEIGGLRVALRGTGL---EGVNLVLFGSQPCPVLedTRSSTQIECKVPSRGAEDAAVHVTlVSGYQSTT 930
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVI--SVSSTTIVCTTPPGTSGLVNVSVT-VGGGGISS 77


                   ....*..
gi 2024491965  931 VTNLFQY 937
Cdd:pfam01833   78 SPLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 84-134 8.74e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.67  E-value: 8.74e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024491965   84 IASVFPASGSLAGGTDLTIMG-DFFEQP--VRVTAAGVPCKVKRVSPRQIICTT 134
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGsNFGTDSsdLKVTIGGTPCTVISVSSTTIVCTT 56
IPT smart00429
ig-like, plexins, transcription factors;
1024-1109 9.17e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 46.64  E-value: 9.17e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  1024 EPLIHyisevfSIEPCCGSFLGGTLLTISG--LGFSQNRSlVSVSINEQTCLVTRLAEETIWCLTPPATNLSNEvsqdVP 1101
Cdd:smart00429    1 DPVIT------RISPTSGPVSGGTEITLCGknLKSISVVF-VEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGS----VP 69


                    ....*...
gi 2024491965  1102 VRVNMLIS 1109
Cdd:smart00429   70 VRTVGLRN 77
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1336-1397 1.21e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.21e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491965 1336 TDVTIKGQRLAWPGDSPVVHVNDQdVCKVTFWNETIVRCQMDCIAPGDHNISISNRSGQACF 1397
Cdd:pfam01833   17 TTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISS 77
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2840-2993 2.67e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 49.53  E-value: 2.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2840 GIKAVMSNGIWLHDNIVFNtVGPGIDLEGKNHSLVRNLIILSRQP------DGLL------NWVA---------GIKVNL 2898
Cdd:COG3420    100 GIYVRGADNAVIENNRIEN-NLFGIYLEGSDNNVIRNNTISGNRDlradrgNGIHlwnspgNVIEgntisggrdGIYLEF 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2899 VIGVSLYGNVVAGSeRVGFHIRgqecfldvdYCSE-----NVAHSNLRGIHLYRGDGfqtcTRITGFLSYKNYDYGMMF- 2972
Cdd:COG3420    179 SDNNVIRNNTIRNL-RYGIHYM---------YSNDnlvegNTFRDNGAGIALMYSKG----NTVRGNTILGNSGYGILLk 244

                          170       180
                   ....*....|....*....|.
gi 2024491965 2973 HLGSSVIIDNVVlVDNTVGLM 2993
Cdd:COG3420    245 ESSDSVIEGNTI-SGNGKGIF 264
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2112-2261 4.67e-05

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 46.63  E-value: 4.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2112 GNRIRNNTVIGLSATdglsnietlspaGIYVR-APANHIEGNTVCAAGYGYFFHLSPERPskmpllTFSENTAHSCTRHG 2190
Cdd:pfam13229   10 NATIKNNTISNNGGY------------GIYLRgSSNATIENNTITNNGGDGIEISGSSNN------TISNNTISNNGGGG 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024491965 2191 LLVYpeylpDSPNGLVQFNSFTvWSSQGGVQIFSSSNLKLQNFQIYACTDFGIDIIESLGNTSVANSVLIG 2261
Cdd:pfam13229   72 IALR-----GSSNNLIENNTIS-NNGGAGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTN 136
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2833-2990 9.54e-05

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 45.48  E-value: 9.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2833 IHGSCGVGIKAVMSNGIWLHDNIVFNTVGPGIDLEGKNHSLVRNLIILSrqpdgllNWVAGIKVNLVIGVSLYGNVVAGS 2912
Cdd:pfam13229   18 ISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISN-------NGGGGIALRGSSNNLIENNTISNN 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2913 ERVGFHIrgqecfldvDYCSENVAHSNL------RGIHLYRGDGFqtcTRITGFLSYKNYDYGMMFHLGSSviidNVVLV 2986
Cdd:pfam13229   91 GGAGIYL---------SDSSNNTIENNIihnnggSGIVIEDSSNN---VTISNNTVTNNKGAGILIVGGSS----NNTVE 154


                   ....
gi 2024491965 2987 DNTV 2990
Cdd:pfam13229  155 NNTF 158
IPT smart00429
ig-like, plexins, transcription factors;
853-924 9.94e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.56  E-value: 9.94e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024491965   853 EPRLVAIEPPRASEIGGLRVALRGTGLEGVNLVLF----GSQPCPVLEdtRSSTQIECKVPSRGAEDAAVHVTLVS 924
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVevgvGEAPCTFSP--SSSTAIVCKTPPYHNIPGSVPVRTVG 74
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2111-2258 1.05e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 47.60  E-value: 1.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2111 KGNRIRNNTVIGLSATDGLSNietlspAGIYV-RAPANHIEGNTVCAAGYGYFFHLSPErpskmplLTFSENTAHSCtRH 2189
Cdd:COG3420    129 DNNVIRNNTISGNRDLRADRG------NGIHLwNSPGNVIEGNTISGGRDGIYLEFSDN-------NVIRNNTIRNL-RY 194

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024491965 2190 GLLVYpeylpDSPNGLVQFNSFTvwSSQGGVQIFSSSNLKLQNFQIYACTDFGI---DIIESL--GNTSVANSV 2258
Cdd:COG3420    195 GIHYM-----YSNDNLVEGNTFR--DNGAGIALMYSKGNTVRGNTILGNSGYGIllkESSDSVieGNTISGNGK 261
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 186-275 1.15e-04

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 45.05  E-value: 1.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  186 LSAGKQSFSSRLRGFFVAPQTNNYTFWIQADGPASLYLSSSQDPQHkvriaslpagslewsgkWVKNWSESWQPKSQKFE 265
Cdd:pfam07691   39 FGEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWIDGELVIDN-----------------WGQHPPDASPEESNTLY 101

                           90
                   ....*....|
gi 2024491965  266 LTAGRRYYLE 275
Cdd:pfam07691  102 LVAGKLYPIR 111
IPT smart00429
ig-like, plexins, transcription factors;
1220-1280 3.24e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.41  E-value: 3.24e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024491965  1220 PRITSIFPSQGSICGGMLLTISGialrarRDLGQVS------LDGNYSCELQSSDNSTIKCMVLPGT 1280
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCG------KNLKSISvvfvevGVGEAPCTFSPSSSTAIVCKTPPYH 62
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 781-844 3.26e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.05  E-value: 3.26e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024491965  781 TVVIRGVGFSEENTTLQVRVKNMTCYVVMSNQTKVVCKMERLPLGVHQLTLLVRPYGFALNAST 844
Cdd:pfam01833   18 TITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPLT 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1408-1487 4.01e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 41.66  E-value: 4.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1408 PQVHQFYPQNFSTNGGGLLTFAGAALK-GKSRTSVLIGQHPCLILNVTCIAIQCTVPPG-NGTRALRLTVDG--ISYDVG 1483
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGtDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGtSGLVNVSVTVGGggISSSPL 80


                   ....
gi 2024491965 1484 KISY 1487
Cdd:pfam01833   81 TFTY 84
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 190-275 8.58e-04

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 42.39  E-value: 8.58e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965   190 KQSFSSRLRGFFVAPQTNNYTFWIQADGPASLYLSSSQDpqhkvriaslpagslewsgkwVKNWSESWQPK--SQKFELT 267
Cdd:smart00758   41 ADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWIDGKLV---------------------IDNWGKHEARPstSSTLYLL 99


                    ....*...
gi 2024491965   268 AGRRYYLE 275
Cdd:smart00758  100 AGGTYPIR 107
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 943-1021 2.87e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 39.35  E-value: 2.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024491965  943 PAVVSLSRNRSGLAGGQELQIGISSFANYRgSDIKVQIGGMWAQIQAQMDSGLNVTLPALAAGWYNVSVIISGVALASN 1021
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS-SDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2562-2685 3.88e-32

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 123.10  E-value: 3.88e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2562 WGGFNcsIPGPGEDVIILPNRTILVDTDLPPLRGLYILGTLEFPTNSSNVLSAACIVVVGGTLNVGSFQHPLErdSKLLV 2641
Cdd:pfam10162    2 WGGGV--VPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPFQ--GKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2024491965 2642 LLRASEgiYCDHLEEISVHPGSIGV--YGKVQIYSSYPEKSWTHLG 2685
Cdd:pfam10162   78 TLHGRP--ELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1764-1882 3.80e-25

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 103.07  E-value: 3.80e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1764 SWPSGRPPQDGANVTVEAGRTLLLGAATAALHLLHLRgGKLIFTGPGPVELHAHYILISdGGELRVGSSEARFHHRAHIY 1843
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2024491965 1844 LYGSLH--SPPLFPYGAKFLAVRN-GTLSIHGWVPKVTFTYL 1882
Cdd:pfam10162   79 LHGRPEldDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKL 120
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1032-1128 7.85e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.79  E-value: 7.85e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1032 EVFSIEPCCGSFLGGTLLTISGLGFSQNRSLVSVSINEQTCLVTRLAEETIWCLTPPATNLSNevsqdVPVRVNMLISNS 1111
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGE-----GPVEVTVDGANV 76

                           90
                   ....*....|....*..
gi 2024491965 1112 SLQNVPvakSITFNYQR 1128
Cdd:cd00603     77 SARVLS---NTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 83-136 6.22e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 58.62  E-value: 6.22e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024491965   83 EIASVFPASGSLAGGTDLTIMGDFF---EQPVRVTAAGVPCKVKRVSPRQIICTTEA 136
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPA 58
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1032-1126 7.69e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 58.24  E-value: 7.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1032 EVFSIEPCCGSFLGGTLLTISGLGFSQNRSLVsVSI-NEQTCLVTRLAEETIWCLTPPATNLSnevsqdvPVRVNMLISN 1110
Cdd:cd00102      2 VITSISPSSGPVSGGTEVTITGSNFGSGSNLR-VTFgGGVPCSVLSVSSTAIVCTTPPYANPG-------PGPVEVTVDR 73

                           90
                   ....*....|....*.
gi 2024491965 1111 SSlqNVPVAKSITFNY 1126
Cdd:cd00102     74 GN--GGITSSPLTFTY 87
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1220-1284 4.33e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 56.31  E-value: 4.33e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024491965 1220 PRITSIFPSQGSICGGMLLTISGIALRARRDLGQVSLdGNYSCELQSSDNSTIKCMVLPGTHPLP 1284
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTPAAATPGE 64
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1035-1097 2.10e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 53.99  E-value: 2.10e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024491965 1035 SIEPCCGSFLGGTLLTISGLGFSQNRSLVSVSINEQTCLVTRLAEETIWCLTPPATNLSNEVS 1097
Cdd:pfam01833    5 SISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVS 67
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 83-162 2.46e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 54.00  E-value: 2.46e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965   83 EIASVFPASGSLAGGTDLTIMGDFF--EQPVRVT-AAGVPCKVKRVSPRQIICTTEAVdrsrmlGDPQPGNRGLLFEVWD 159
Cdd:cd00102      2 VITSISPSSGPVSGGTEVTITGSNFgsGSNLRVTfGGGVPCSVLSVSSTAIVCTTPPY------ANPGPGPVEVTVDRGN 75


                   ...
gi 2024491965  160 DAS 162
Cdd:cd00102     76 GGI 78
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1220-1313 3.26e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 53.62  E-value: 3.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1220 PRITSIFPSQGSICGGMLLTISGIALRARRDLgQVSLDGNYSCELQSSDNSTIKCMVLPGTHPLPyqwwaevswaLNVTV 1299
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNL-RVTFGGGVPCSVLSVSSTAIVCTTPPYANPGP----------GPVEV 69

                           90
                   ....*....|....
gi 2024491965 1300 TVSGISSVCLGDCT 1313
Cdd:cd00102     70 TVDRGNGGITSSPL 83
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 84-134 3.84e-08

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 53.38  E-value: 3.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024491965   84 IASVFPASGSLAGGTDLTIMGDFFE--QPVRVTAAGVPCKVKRVSPRQIICTT 134
Cdd:cd01179      3 ITSLSPSYGPQSGGTRLTITGKHLNagSSVRVTVGGQPCKILSVSSSQIVCLT 55
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 854-937 1.10e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.07  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  854 PRLVAIEPPRASEIGGLRVALRGTGLEGVNL---VLFGSQPCPVLEdtRSSTQIECKVPSRGAEDAA---VHVTLVSGYQ 927
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVLN--VSSTEIVCRTPAAATPGEGpveVTVDGANVSA 78

                           90
                   ....*....|
gi 2024491965  928 STTVTNLFQY 937
Cdd:cd00603     79 RVLSNTTFTY 88
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1033-1126 3.92e-07

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 50.30  E-value: 3.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1033 VFSIEPCCGSFLGGTLLTISGlGFSQNRSLVSVSINEQTCLVTRLAEETIWCLTPPATNLSnevsqdvPVRVNMLISNSs 1112
Cdd:cd01179      3 ITSLSPSYGPQSGGTRLTITG-KHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPG-------EAPVKVLIDGA- 73

                           90
                   ....*....|....
gi 2024491965 1113 lqnvPVAKSITFNY 1126
Cdd:cd01179     74 ----RRLAPLVFTY 83
IPT smart00429
ig-like, plexins, transcription factors;
83-140 6.38e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.11  E-value: 6.38e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491965    83 EIASVFPASGSLAGGTDLTIMGDFF----EQPVRVTAAGVPCKVKRVSPRQIICTTEAVDRS 140
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLksisVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNI 64
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1408-1477 6.92e-07

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 49.53  E-value: 6.92e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491965 1408 PQVHQFYPQNFSTNGGGLLTFAGAALKGKSRTSVLIGQHPCLILNVTCIAIQCTVPPGN--GTRALRLTVDG 1477
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAspGEAPVKVLIDG 72
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1220-1280 4.12e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.44  E-value: 4.12e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024491965 1220 PRITSIFPSQGSICGGMLLTISGIALRARRDLGQVSLdGNYSCELQSSDNSTIKCMVLPGT 1280
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTI-GGTPCTVISVSSTTIVCTTPPGT 60
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 854-937 7.08e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 47.07  E-value: 7.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  854 PRLVAIEPPRASEIGGLRVALRGTGL-EGVNL-VLF-GSQPCPVLEdtRSSTQIECKVPS-RGAEDAAVHVTLVSGYQST 929
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFgSGSNLrVTFgGGVPCSVLS--VSSTAIVCTTPPyANPGPGPVEVTVDRGNGGI 78


                   ....*....
gi 2024491965  930 TVTNL-FQY 937
Cdd:cd00102     79 TSSPLtFTY 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 854-937 8.57e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.67  E-value: 8.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  854 PRLVAIEPPRASEIGGLRVALRGTGL---EGVNLVLFGSQPCPVLedTRSSTQIECKVPSRGAEDAAVHVTlVSGYQSTT 930
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVI--SVSSTTIVCTTPPGTSGLVNVSVT-VGGGGISS 77


                   ....*..
gi 2024491965  931 VTNLFQY 937
Cdd:pfam01833   78 SPLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 84-134 8.74e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.67  E-value: 8.74e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024491965   84 IASVFPASGSLAGGTDLTIMG-DFFEQP--VRVTAAGVPCKVKRVSPRQIICTT 134
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGsNFGTDSsdLKVTIGGTPCTVISVSSTTIVCTT 56
IPT smart00429
ig-like, plexins, transcription factors;
1024-1109 9.17e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 46.64  E-value: 9.17e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  1024 EPLIHyisevfSIEPCCGSFLGGTLLTISG--LGFSQNRSlVSVSINEQTCLVTRLAEETIWCLTPPATNLSNEvsqdVP 1101
Cdd:smart00429    1 DPVIT------RISPTSGPVSGGTEITLCGknLKSISVVF-VEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGS----VP 69


                    ....*...
gi 2024491965  1102 VRVNMLIS 1109
Cdd:smart00429   70 VRTVGLRN 77
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1336-1397 1.21e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.21e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491965 1336 TDVTIKGQRLAWPGDSPVVHVNDQdVCKVTFWNETIVRCQMDCIAPGDHNISISNRSGQACF 1397
Cdd:pfam01833   17 TTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISS 77
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2840-2993 2.67e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 49.53  E-value: 2.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2840 GIKAVMSNGIWLHDNIVFNtVGPGIDLEGKNHSLVRNLIILSRQP------DGLL------NWVA---------GIKVNL 2898
Cdd:COG3420    100 GIYVRGADNAVIENNRIEN-NLFGIYLEGSDNNVIRNNTISGNRDlradrgNGIHlwnspgNVIEgntisggrdGIYLEF 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2899 VIGVSLYGNVVAGSeRVGFHIRgqecfldvdYCSE-----NVAHSNLRGIHLYRGDGfqtcTRITGFLSYKNYDYGMMF- 2972
Cdd:COG3420    179 SDNNVIRNNTIRNL-RYGIHYM---------YSNDnlvegNTFRDNGAGIALMYSKG----NTVRGNTILGNSGYGILLk 244

                          170       180
                   ....*....|....*....|.
gi 2024491965 2973 HLGSSVIIDNVVlVDNTVGLM 2993
Cdd:COG3420    245 ESSDSVIEGNTI-SGNGKGIF 264
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 83-136 3.77e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 45.00  E-value: 3.77e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024491965   83 EIASVFPASGSLAGGTDLTIMGDFFEQPV-----RVTAAGVPCKV---KRVSPRQIICTTEA 136
Cdd:cd01180      2 VITEFFPLSGPLEGGTRLTICGSNLGLRKndvrhGVRVGGVPCNPeppEYSSSEKIVCTTGP 63
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2112-2261 4.67e-05

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 46.63  E-value: 4.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2112 GNRIRNNTVIGLSATdglsnietlspaGIYVR-APANHIEGNTVCAAGYGYFFHLSPERPskmpllTFSENTAHSCTRHG 2190
Cdd:pfam13229   10 NATIKNNTISNNGGY------------GIYLRgSSNATIENNTITNNGGDGIEISGSSNN------TISNNTISNNGGGG 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024491965 2191 LLVYpeylpDSPNGLVQFNSFTvWSSQGGVQIFSSSNLKLQNFQIYACTDFGIDIIESLGNTSVANSVLIG 2261
Cdd:pfam13229   72 IALR-----GSSNNLIENNTIS-NNGGAGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTN 136
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2833-2990 9.54e-05

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 45.48  E-value: 9.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2833 IHGSCGVGIKAVMSNGIWLHDNIVFNTVGPGIDLEGKNHSLVRNLIILSrqpdgllNWVAGIKVNLVIGVSLYGNVVAGS 2912
Cdd:pfam13229   18 ISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISN-------NGGGGIALRGSSNNLIENNTISNN 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2913 ERVGFHIrgqecfldvDYCSENVAHSNL------RGIHLYRGDGFqtcTRITGFLSYKNYDYGMMFHLGSSviidNVVLV 2986
Cdd:pfam13229   91 GGAGIYL---------SDSSNNTIENNIihnnggSGIVIEDSSNN---VTISNNTVTNNKGAGILIVGGSS----NNTVE 154


                   ....
gi 2024491965 2987 DNTV 2990
Cdd:pfam13229  155 NNTF 158
IPT smart00429
ig-like, plexins, transcription factors;
853-924 9.94e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.56  E-value: 9.94e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024491965   853 EPRLVAIEPPRASEIGGLRVALRGTGLEGVNLVLF----GSQPCPVLEdtRSSTQIECKVPSRGAEDAAVHVTLVS 924
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVevgvGEAPCTFSP--SSSTAIVCKTPPYHNIPGSVPVRTVG 74
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2111-2258 1.05e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 47.60  E-value: 1.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2111 KGNRIRNNTVIGLSATDGLSNietlspAGIYV-RAPANHIEGNTVCAAGYGYFFHLSPErpskmplLTFSENTAHSCtRH 2189
Cdd:COG3420    129 DNNVIRNNTISGNRDLRADRG------NGIHLwNSPGNVIEGNTISGGRDGIYLEFSDN-------NVIRNNTIRNL-RY 194

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024491965 2190 GLLVYpeylpDSPNGLVQFNSFTvwSSQGGVQIFSSSNLKLQNFQIYACTDFGI---DIIESL--GNTSVANSV 2258
Cdd:COG3420    195 GIHYM-----YSNDNLVEGNTFR--DNGAGIALMYSKGNTVRGNTILGNSGYGIllkESSDSVieGNTISGNGK 261
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 186-275 1.15e-04

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 45.05  E-value: 1.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  186 LSAGKQSFSSRLRGFFVAPQTNNYTFWIQADGPASLYLSSSQDPQHkvriaslpagslewsgkWVKNWSESWQPKSQKFE 265
Cdd:pfam07691   39 FGEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWIDGELVIDN-----------------WGQHPPDASPEESNTLY 101

                           90
                   ....*....|
gi 2024491965  266 LTAGRRYYLE 275
Cdd:pfam07691  102 LVAGKLYPIR 111
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1220-1285 1.65e-04

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 42.98  E-value: 1.65e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024491965 1220 PRITSIFPSQGSICGGMLLTISGIALRARRDLgQVSLDGnYSCELQSSDNSTIKCMVLPGTHPLPY 1285
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSV-RVTVGG-QPCKILSVSSSQIVCLTPPSASPGEA 64
IPT smart00429
ig-like, plexins, transcription factors;
1220-1280 3.24e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.41  E-value: 3.24e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024491965  1220 PRITSIFPSQGSICGGMLLTISGialrarRDLGQVS------LDGNYSCELQSSDNSTIKCMVLPGT 1280
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCG------KNLKSISvvfvevGVGEAPCTFSPSSSTAIVCKTPPYH 62
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 781-844 3.26e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.05  E-value: 3.26e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024491965  781 TVVIRGVGFSEENTTLQVRVKNMTCYVVMSNQTKVVCKMERLPLGVHQLTLLVRPYGFALNAST 844
Cdd:pfam01833   18 TITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPLT 81
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2111-2259 3.92e-04

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 43.93  E-value: 3.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2111 KGNRIRNNTVIGLSATDG------LSNIETLSPAGIYVRAPANH-IEGNTV--CAAGYGYFFHLSPerpskmplLTFSEN 2181
Cdd:pfam13229   14 KNNTISNNGGYGIYLRGSsnatieNNTITNNGGDGIEISGSSNNtISNNTIsnNGGGGIALRGSSN--------NLIENN 85

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024491965 2182 TAHSCTRHGLLVYpeylpDSPNGLVQFNSFTVWSSQGGVQIFSSSNLKLQNFQIYACTDFGIDIIESLGNTSVANSVL 2259
Cdd:pfam13229   86 TISNNGGAGIYLS-----DSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTNNKGAGILIVGGSSNNTVENNTF 158
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1408-1487 4.01e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 41.66  E-value: 4.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1408 PQVHQFYPQNFSTNGGGLLTFAGAALK-GKSRTSVLIGQHPCLILNVTCIAIQCTVPPG-NGTRALRLTVDG--ISYDVG 1483
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGtDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGtSGLVNVSVTVGGggISSSPL 80


                   ....
gi 2024491965 1484 KISY 1487
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1408-1486 7.27e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 41.29  E-value: 7.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1408 PQVHQFYPQNFSTNGGGLLTFAGAAL-KGKSRTSVLIGQHPCLILNVTCIAIQCTVPPGN--GTRALRLTVDGISYDVGK 1484
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLgSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpGEGPVEVTVDGANVSARV 80


                   ..
gi 2024491965 1485 IS 1486
Cdd:cd00603     81 LS 82
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 190-275 8.58e-04

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 42.39  E-value: 8.58e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965   190 KQSFSSRLRGFFVAPQTNNYTFWIQADGPASLYLSSSQDpqhkvriaslpagslewsgkwVKNWSESWQPK--SQKFELT 267
Cdd:smart00758   41 ADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWIDGKLV---------------------IDNWGKHEARPstSSTLYLL 99


                    ....*...
gi 2024491965   268 AGRRYYLE 275
Cdd:smart00758  100 AGGTYPIR 107
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 943-1021 2.87e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 39.35  E-value: 2.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024491965  943 PAVVSLSRNRSGLAGGQELQIGISSFANYRgSDIKVQIGGMWAQIQAQMDSGLNVTLPALAAGWYNVSVIISGVALASN 1021
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS-SDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 854-937 3.70e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.22  E-value: 3.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  854 PRLVAIEPPRASEIGGLRVALRGTGL----EGVNL-VLFGSQPCPVLEDT-RSSTQIECKVPSRG--AEDAAVHVTLVSG 925
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLglrkNDVRHgVRVGGVPCNPEPPEySSSEKIVCTTGPAGnpVFNGPVEVTVGHG 80

                           90
                   ....*....|..
gi 2024491965  926 YQSTTVTNLFQY 937
Cdd:cd01180     81 SFRTESSEGFSF 92
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 854-937 4.60e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 38.74  E-value: 4.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965  854 PRLVAIEPPRASEIGGLRVALRGTGLE-GVNL-VLFGSQPCPVLEdtRSSTQIECKVPSrGAEDAAVHVTLVSGYQSTTV 931
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNaGSSVrVTVGGQPCKILS--VSSSQIVCLTPP-SASPGEAPVKVLIDGARRLA 77


                   ....*.
gi 2024491965  932 TNLFQY 937
Cdd:cd01179     78 PLVFTY 83
NosD pfam05048
Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to ...
 2075-2252 6.00e-03

Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ). This region forms a parallel beta helix domain.


Pssm-ID: 428281 [Multi-domain]  Cd Length: 215  Bit Score: 41.25  E-value: 6.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2075 SFGQGLCLTGISNLSVDSNVFFNISGHGLLLGsglEKGNRIRNNTVIGLsatdglsnietlsPAGIYVR-APANHIEGNT 2153
Cdd:pfam05048   17 SRGNGIQLWNTEGNVISNNDIINSRDGIYLDA---SNNNTITGNRISNL-------------RYGIHLMnSNDNTISDNV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 2154 VCAAGYGYFFHLSPERpskmpllTFSENTAHSCTRHGLlvypeYLPDSPNGLVQFNSFTVWSSQgGVQIFSSSNLKLQNF 2233
Cdd:pfam05048   81 FSGNTAGIALMSSSNN-------TLENNTISGNTNYGI-----LLSDSSNNTISNNTISNNNGK-GIFLYNSDYNTITGN 147

                          170       180
                   ....*....|....*....|
gi 2024491965 2234 QIYACtDFGI-DIIESLGNT 2252
Cdd:pfam05048  148 RITSN-GIGIhFLAGSNGNT 166
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1220-1313 7.48e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 38.45  E-value: 7.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1220 PRITSIFPSQGSICGGMLLTISGIAL--RARRDLGQVSLdGNYSCELQ---SSDNSTIKCMVLPGTHPLPyqwwaevswa 1294
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLglRKNDVRHGVRV-GGVPCNPEppeYSSSEKIVCTTGPAGNPVF---------- 69

                           90
                   ....*....|....*....
gi 2024491965 1295 lnvtvtvSGISSVCLGDCT 1313
Cdd:cd01180     70 -------NGPVEVTVGHGS 81
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1033-1126 8.30e-03

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 38.55  E-value: 8.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024491965 1033 VFSIEPCcGSFL-GGTLLTISGLGFS--QNRSLVS--VSINEQTCLVtrLAEETIWCLTPPATNLsNEVSQDVPVRVNML 1107
Cdd:cd01181      3 ITRIEPE-WSFLsGGTPITVTGTNLNtvQEPRIRVkyGGVEKTSCKV--RNSTLMTCPAPSLALL-NRSPEPGERPVEFG 78

                           90
                   ....*....|....*....
gi 2024491965 1108 ISNSSLQNVPVAKSITFNY 1126
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSY 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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