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Conserved domains on  [gi|2024502309|ref|XP_040527822|]
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protocadherin-11 X-linked isoform X4 [Gallus gallus]

Protein Classification

protocadherin( domain architecture ID 10182726)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 791-991 3.38e-84

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


:

Pssm-ID: 462451  Cd Length: 217  Bit Score: 273.54  E-value: 3.38e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  791 TVTNSSYIQELVRRNMETPVGQNI-GDGEITPQTNDYVKIIIAIIAGTMTVILVIFVTALVR-CRQT--PRHKVVQKnkQ 866
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  867 SGEWVSPNQENRQIKKK------KKKKKRSPKSLLLNFVTIEESKPDDPGHEHINGTLDIPVeleeqtmgkynwaTTPTT 940
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKkkkkkkRPKPAKLPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024502309  941 FKPDSPDLAKHYKSASPQPTFQIKPETPVPPKKHHVIQELPLDNTFVVGCD 991
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSASKKHQAVQELPLDNTFVGTGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 489-582 1.55e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 130.51  E-value: 1.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  489 LSIPENNAPGTQLTKISATDADSGRNAEISY-ILGSDAPPIFNLDRRTGILTAVRKLDREKQDRYSFTVLAKDNGMPPLQ 567
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 2024502309  568 TNATVTVSVLDQNDN 582
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-685 4.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 4.37e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  590 EYNFYVPENLPMYGTVGLITVTDADSGENAAVTLSILNGRDN--FIIDPLTGVIRPNITFDREQQGSYTFQVKAVDGGRL 667
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024502309  668 QRSSTAKVTINVVDVNDN 685
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 270-367 5.62e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  270 IEVSIPENAPVGTSVSQLHATDADLGSNAQIHFYFSnqiSSLAKKLFAIDNATGLITIREPLDREESPVHKLTVLASDGS 349
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2024502309  350 STP--SRATVTVNVTDINDN 367
Cdd:cd11304     79 GPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 143-261 1.44e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.44e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  143 VINISIPENTAINSRYSVPSAIDPDIGVNGIQHYellkpktapkrtfgSITNDQGQNVFgldIIETPEGDkwpqLIVQQI 222
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTY--------------SIVSGNEDGLF---SIDPSTGE----ITTAKP 59

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2024502309  223 LDREQKDTYVMKIKVEDGGSPPRSSTAILQVTVTDVNDN 261
Cdd:cd11304     60 LDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 697-788 8.20e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 8.20e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  697 SYEL-VPTSSSPGSVVTKVFAVDNDTGMNAELRYSIIGGNSRGLFAIDQLTGNITLKEKVITSDHGLHRLVIKVNDLGQP 775
Cdd:cd11304      1 SYEVsVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 2024502309  776 eSLYTIALVHLFV 788
Cdd:cd11304     81 -PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 383-478 7.18e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 7.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  383 TVLLSEKAPLNTKIALITVMDKDSDLNGKVTCF---TDHDVPFRLKPvfdNQFLLETATFLDYESTREYAIKIVASDSGK 459
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSivsGNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024502309  460 PPLNQSAMLLIKIKDENDN 478
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 27-135 1.48e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 1.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   27 NYTVREELPENVLIGNLLKdlnltLDPDVPLSSPLQFKLVYKTGDvPLVRVEENTGEIfTTANRIDREKLCSgifsenrc 106
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSA-----TDPDSGENGEVTYSIVSGNED-GLFSIDPSTGEI-TTAKPLDREEQSS-------- 67

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024502309  107 fYEVEV-----AVLPDEVFRLVKIRflIEDINDN 135
Cdd:cd11304     68 -YTLTVtatdgGGPPLSSTATVTIT--VLDVNDN 98
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 791-991 3.38e-84

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 273.54  E-value: 3.38e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  791 TVTNSSYIQELVRRNMETPVGQNI-GDGEITPQTNDYVKIIIAIIAGTMTVILVIFVTALVR-CRQT--PRHKVVQKnkQ 866
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  867 SGEWVSPNQENRQIKKK------KKKKKRSPKSLLLNFVTIEESKPDDPGHEHINGTLDIPVeleeqtmgkynwaTTPTT 940
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKkkkkkkRPKPAKLPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024502309  941 FKPDSPDLAKHYKSASPQPTFQIKPETPVPPKKHHVIQELPLDNTFVVGCD 991
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSASKKHQAVQELPLDNTFVGTGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 489-582 1.55e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 130.51  E-value: 1.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  489 LSIPENNAPGTQLTKISATDADSGRNAEISY-ILGSDAPPIFNLDRRTGILTAVRKLDREKQDRYSFTVLAKDNGMPPLQ 567
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 2024502309  568 TNATVTVSVLDQNDN 582
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-685 4.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 4.37e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  590 EYNFYVPENLPMYGTVGLITVTDADSGENAAVTLSILNGRDN--FIIDPLTGVIRPNITFDREQQGSYTFQVKAVDGGRL 667
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024502309  668 QRSSTAKVTINVVDVNDN 685
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 270-367 5.62e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  270 IEVSIPENAPVGTSVSQLHATDADLGSNAQIHFYFSnqiSSLAKKLFAIDNATGLITIREPLDREESPVHKLTVLASDGS 349
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2024502309  350 STP--SRATVTVNVTDINDN 367
Cdd:cd11304     79 GPPlsSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 505-584 8.71e-28

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 107.44  E-value: 8.71e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   505 SATDADSGRNAEISY-ILGSDAPPIFNLDRRTGILTAVRKLDREKQDRYSFTVLAKDNGMPPLQTNATVTVSVLDQNDNS 583
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024502309   584 P 584
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
270-362 1.09e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 99.30  E-value: 1.09e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  270 IEVSIPENAPVGTSVSQLHATDADLGSNAQIHFYFSNQISSlakKLFAIDNATGLITIREPLDREESPVHKLTVLASDGS 349
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG---GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 2024502309  350 STPSRATVTVNVT 362
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
490-577 4.57e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.37  E-value: 4.57e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  490 SIPENNAPGTQLTKISATDADSGRNAEISY-ILGSDAPPIFNLDRRTGILTAVRKLDREKQDRYSFTVLAKDNGMPPLQT 568
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 2024502309  569 NATVTVSVL 577
Cdd:pfam00028   84 TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 609-687 9.59e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 9.59e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   609 TVTDADSGENAAVTLSILNGRDN--FIIDPLTGVIRPNITFDREQQGSYTFQVKAVDGGRLQRSSTAKVTINVVDVNDNR 686
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024502309   687 P 687
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 143-261 1.44e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.44e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  143 VINISIPENTAINSRYSVPSAIDPDIGVNGIQHYellkpktapkrtfgSITNDQGQNVFgldIIETPEGDkwpqLIVQQI 222
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTY--------------SIVSGNEDGLF---SIDPSTGE----ITTAKP 59

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2024502309  223 LDREQKDTYVMKIKVEDGGSPPRSSTAILQVTVTDVNDN 261
Cdd:cd11304     60 LDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
591-679 2.05e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 2.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  591 YNFYVPENLPMYGTVGLITVTDADSGENAAVTLSILNG--RDNFIIDPLTGVIRPNITFDREQQGSYTFQVKAVDGGRLQ 668
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024502309  669 RSSTAKVTINV 679
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 288-369 2.55e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.33  E-value: 2.55e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   288 HATDADLGSNAQIHFYFSnqiSSLAKKLFAIDNATGLITIREPLDREESPVHKLTVLASDGSSTP--SRATVTVNVTDIN 365
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 2024502309   366 DNVP 369
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 697-788 8.20e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 8.20e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  697 SYEL-VPTSSSPGSVVTKVFAVDNDTGMNAELRYSIIGGNSRGLFAIDQLTGNITLKEKVITSDHGLHRLVIKVNDLGQP 775
Cdd:cd11304      1 SYEVsVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 2024502309  776 eSLYTIALVHLFV 788
Cdd:cd11304     81 -PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 383-478 7.18e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 7.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  383 TVLLSEKAPLNTKIALITVMDKDSDLNGKVTCF---TDHDVPFRLKPvfdNQFLLETATFLDYESTREYAIKIVASDSGK 459
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSivsGNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024502309  460 PPLNQSAMLLIKIKDENDN 478
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 162-263 9.07e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 9.07e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   162 SAIDPDIGVNGIQHYELLkpktapkrtfgsitndqGQNVFGLDIIETPEGdkwpQLIVQQILDREQKDTYVMKIKVEDGG 241
Cdd:smart00112    1 SATDADSGENGKVTYSIL-----------------SGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGG 59

                            90       100
                    ....*....|....*....|..
gi 2024502309   242 SPPRSSTAILQVTVTDVNDNRP 263
Cdd:smart00112   60 GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 400-480 5.74e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 5.74e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   400 TVMDKDSDLNGKVTCF---TDHDVPFRLKPVFDnqfLLETATFLDYESTREYAIKIVASDSGKPPLNQSAMLLIKIKDEN 476
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 2024502309   477 DNAP 480
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
144-256 3.31e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 3.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  144 INISIPENTAINSRYSVPSAIDPDIGVNGIQHYELLkpktapkrtfgsitndqGQNVFGLDIIETPEGDkwpqLIVQQIL 223
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-----------------GGGPGGNFRIDPDTGD----ISTTKPL 59

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2024502309  224 DREQKDTYVMKIKVEDGGSPPRSSTAILQVTVT 256
Cdd:pfam00028   60 DRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
701-788 4.57e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 4.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  701 VPTSSSPGSVVTKVFAVDNDTGMNAELRYSIIGGNSRGLFAIDQLTGNITLKEKVITSDHGLHRLVIKVNDLGQPeSLYT 780
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSS 83


                   ....*...
gi 2024502309  781 IALVHLFV 788
Cdd:pfam00028   84 TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 716-788 2.66e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 2.66e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024502309   716 AVDNDTGMNAELRYSIIGGNSRGLFAIDQLTGNITLKEKVITSDHGLHRLVIKVNDLGQPeSLYTIALVHLFV 788
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
386-472 3.40e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 3.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  386 LSEKAPLNTKIALITVMDKDSDLNGKVTcftdhdvpFR-LKPVFDNQFLLETAT-------FLDYESTREYAIKIVASDS 457
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIF--------YSiLGGGPGGNFRIDPDTgdisttkPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 2024502309  458 GKPPLNQSAMLLIKI 472
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 27-135 1.48e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 1.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   27 NYTVREELPENVLIGNLLKdlnltLDPDVPLSSPLQFKLVYKTGDvPLVRVEENTGEIfTTANRIDREKLCSgifsenrc 106
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSA-----TDPDSGENGEVTYSIVSGNED-GLFSIDPSTGEI-TTAKPLDREEQSS-------- 67

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024502309  107 fYEVEV-----AVLPDEVFRLVKIRflIEDINDN 135
Cdd:cd11304     68 -YTLTVtatdgGGPPLSSTATVTIT--VLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-99 4.33e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 45.98  E-value: 4.33e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024502309   28 YTVREELPENVLIGNLLKDLNLtldpDVPLSSPLQFKLVYKtGDVPLVRVEENTGEIFtTANRIDREKLCSG 99
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGL----EVGELAARGARVVSK-GNKQYFQLNPETGDLL-LNEKLDREELCGS 69
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 52-137 7.54e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.34  E-value: 7.54e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309    52 DPDVPLSSPLQFKLVYKTGDvPLVRVEENTGEIFTTAnRIDREKlcsgifsenRCFYEVEV-----AVLPDEVFRLVKIR 126
Cdd:smart00112    4 DADSGENGKVTYSILSGNDD-GLFSIDPETGEITTTK-PLDREE---------QPEYTLTVeatdgGGPPLSSTATVTIT 72

                            90
                    ....*....|.
gi 2024502309   127 flIEDINDNAP 137
Cdd:smart00112   73 --VLDVNDNAP 81
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 791-991 3.38e-84

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 273.54  E-value: 3.38e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  791 TVTNSSYIQELVRRNMETPVGQNI-GDGEITPQTNDYVKIIIAIIAGTMTVILVIFVTALVR-CRQT--PRHKVVQKnkQ 866
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  867 SGEWVSPNQENRQIKKK------KKKKKRSPKSLLLNFVTIEESKPDDPGHEHINGTLDIPVeleeqtmgkynwaTTPTT 940
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKkkkkkkRPKPAKLPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024502309  941 FKPDSPDLAKHYKSASPQPTFQIKPETPVPPKKHHVIQELPLDNTFVVGCD 991
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSASKKHQAVQELPLDNTFVGTGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 489-582 1.55e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 130.51  E-value: 1.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  489 LSIPENNAPGTQLTKISATDADSGRNAEISY-ILGSDAPPIFNLDRRTGILTAVRKLDREKQDRYSFTVLAKDNGMPPLQ 567
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 2024502309  568 TNATVTVSVLDQNDN 582
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 590-685 4.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 4.37e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  590 EYNFYVPENLPMYGTVGLITVTDADSGENAAVTLSILNGRDN--FIIDPLTGVIRPNITFDREQQGSYTFQVKAVDGGRL 667
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024502309  668 QRSSTAKVTINVVDVNDN 685
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 270-367 5.62e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  270 IEVSIPENAPVGTSVSQLHATDADLGSNAQIHFYFSnqiSSLAKKLFAIDNATGLITIREPLDREESPVHKLTVLASDGS 349
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2024502309  350 STP--SRATVTVNVTDINDN 367
Cdd:cd11304     79 GPPlsSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 505-584 8.71e-28

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 107.44  E-value: 8.71e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   505 SATDADSGRNAEISY-ILGSDAPPIFNLDRRTGILTAVRKLDREKQDRYSFTVLAKDNGMPPLQTNATVTVSVLDQNDNS 583
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024502309   584 P 584
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
270-362 1.09e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 99.30  E-value: 1.09e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  270 IEVSIPENAPVGTSVSQLHATDADLGSNAQIHFYFSNQISSlakKLFAIDNATGLITIREPLDREESPVHKLTVLASDGS 349
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG---GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 2024502309  350 STPSRATVTVNVT 362
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
490-577 4.57e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.37  E-value: 4.57e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  490 SIPENNAPGTQLTKISATDADSGRNAEISY-ILGSDAPPIFNLDRRTGILTAVRKLDREKQDRYSFTVLAKDNGMPPLQT 568
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 2024502309  569 NATVTVSVL 577
Cdd:pfam00028   84 TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 609-687 9.59e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 9.59e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   609 TVTDADSGENAAVTLSILNGRDN--FIIDPLTGVIRPNITFDREQQGSYTFQVKAVDGGRLQRSSTAKVTINVVDVNDNR 686
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024502309   687 P 687
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 143-261 1.44e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.44e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  143 VINISIPENTAINSRYSVPSAIDPDIGVNGIQHYellkpktapkrtfgSITNDQGQNVFgldIIETPEGDkwpqLIVQQI 222
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTY--------------SIVSGNEDGLF---SIDPSTGE----ITTAKP 59

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2024502309  223 LDREQKDTYVMKIKVEDGGSPPRSSTAILQVTVTDVNDN 261
Cdd:cd11304     60 LDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
591-679 2.05e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 2.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  591 YNFYVPENLPMYGTVGLITVTDADSGENAAVTLSILNG--RDNFIIDPLTGVIRPNITFDREQQGSYTFQVKAVDGGRLQ 668
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024502309  669 RSSTAKVTINV 679
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 288-369 2.55e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.33  E-value: 2.55e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   288 HATDADLGSNAQIHFYFSnqiSSLAKKLFAIDNATGLITIREPLDREESPVHKLTVLASDGSSTP--SRATVTVNVTDIN 365
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 2024502309   366 DNVP 369
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 697-788 8.20e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 8.20e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  697 SYEL-VPTSSSPGSVVTKVFAVDNDTGMNAELRYSIIGGNSRGLFAIDQLTGNITLKEKVITSDHGLHRLVIKVNDLGQP 775
Cdd:cd11304      1 SYEVsVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 2024502309  776 eSLYTIALVHLFV 788
Cdd:cd11304     81 -PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 383-478 7.18e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 7.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  383 TVLLSEKAPLNTKIALITVMDKDSDLNGKVTCF---TDHDVPFRLKPvfdNQFLLETATFLDYESTREYAIKIVASDSGK 459
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSivsGNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024502309  460 PPLNQSAMLLIKIKDENDN 478
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 162-263 9.07e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 9.07e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   162 SAIDPDIGVNGIQHYELLkpktapkrtfgsitndqGQNVFGLDIIETPEGdkwpQLIVQQILDREQKDTYVMKIKVEDGG 241
Cdd:smart00112    1 SATDADSGENGKVTYSIL-----------------SGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGG 59

                            90       100
                    ....*....|....*....|..
gi 2024502309   242 SPPRSSTAILQVTVTDVNDNRP 263
Cdd:smart00112   60 GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 400-480 5.74e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 5.74e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   400 TVMDKDSDLNGKVTCF---TDHDVPFRLKPVFDnqfLLETATFLDYESTREYAIKIVASDSGKPPLNQSAMLLIKIKDEN 476
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 2024502309   477 DNAP 480
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
144-256 3.31e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 3.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  144 INISIPENTAINSRYSVPSAIDPDIGVNGIQHYELLkpktapkrtfgsitndqGQNVFGLDIIETPEGDkwpqLIVQQIL 223
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-----------------GGGPGGNFRIDPDTGD----ISTTKPL 59

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2024502309  224 DREQKDTYVMKIKVEDGGSPPRSSTAILQVTVT 256
Cdd:pfam00028   60 DRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
701-788 4.57e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 4.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  701 VPTSSSPGSVVTKVFAVDNDTGMNAELRYSIIGGNSRGLFAIDQLTGNITLKEKVITSDHGLHRLVIKVNDLGQPeSLYT 780
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSS 83


                   ....*...
gi 2024502309  781 IALVHLFV 788
Cdd:pfam00028   84 TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 716-788 2.66e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 2.66e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024502309   716 AVDNDTGMNAELRYSIIGGNSRGLFAIDQLTGNITLKEKVITSDHGLHRLVIKVNDLGQPeSLYTIALVHLFV 788
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
386-472 3.40e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 3.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  386 LSEKAPLNTKIALITVMDKDSDLNGKVTcftdhdvpFR-LKPVFDNQFLLETAT-------FLDYESTREYAIKIVASDS 457
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIF--------YSiLGGGPGGNFRIDPDTgdisttkPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 2024502309  458 GKPPLNQSAMLLIKI 472
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 486-582 1.46e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 53.50  E-value: 1.46e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  486 IIGLSIPENNAPGTQLTKI-SATDADSGRNAEISYiLGSDAPP-IFNLDRRTGILTAVRKLDREKQDRYSFTVLAKDNGM 563
Cdd:cd00031      1 IPDGSAVEGRSRGSFRVSIpTDLIASSGEIIKISA-AGKEALPsWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                           90
                   ....*....|....*....
gi 2024502309  564 PPLQTNATVTVSVLDQNDN 582
Cdd:cd00031     80 NVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 27-135 1.48e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 1.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309   27 NYTVREELPENVLIGNLLKdlnltLDPDVPLSSPLQFKLVYKTGDvPLVRVEENTGEIfTTANRIDREKLCSgifsenrc 106
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSA-----TDPDSGENGEVTYSIVSGNED-GLFSIDPSTGEI-TTAKPLDREEQSS-------- 67

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024502309  107 fYEVEV-----AVLPDEVFRLVKIRflIEDINDN 135
Cdd:cd11304     68 -YTLTVtatdgGGPPLSSTATVTIT--VLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-99 4.33e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 45.98  E-value: 4.33e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024502309   28 YTVREELPENVLIGNLLKDLNLtldpDVPLSSPLQFKLVYKtGDVPLVRVEENTGEIFtTANRIDREKLCSG 99
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGL----EVGELAARGARVVSK-GNKQYFQLNPETGDLL-LNEKLDREELCGS 69
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 52-137 7.54e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.34  E-value: 7.54e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309    52 DPDVPLSSPLQFKLVYKTGDvPLVRVEENTGEIFTTAnRIDREKlcsgifsenRCFYEVEV-----AVLPDEVFRLVKIR 126
Cdd:smart00112    4 DADSGENGKVTYSILSGNDD-GLFSIDPETGEITTTK-PLDREE---------QPEYTLTVeatdgGGPPLSSTATVTIT 72

                            90
                    ....*....|.
gi 2024502309   127 flIEDINDNAP 137
Cdd:smart00112   73 --VLDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 270-367 2.24e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.86  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024502309  270 IEVSIPENAPVGTSVSQLhatDADLGSNAQIHFYFSNQISSLAKKLFAIDNATGLITIREPLDREESPVHKLTVLA-SDG 348
Cdd:cd00031      2 PDGSAVEGRSRGSFRVSI---PTDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAaSLG 78

                           90       100
                   ....*....|....*....|
gi 2024502309  349 SSTPSRATV-TVNVTDINDN 367
Cdd:cd00031     79 ANVPQTSSVfSIEVYDENDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 270-335 2.79e-03

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 37.89  E-value: 2.79e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024502309  270 IEVSIPENAPVGTSVSQLhATD-----ADLGS-NAQIhfyfsnqISSLAKKLFAIDNATGLITIREPLDREE 335
Cdd:pfam08266    2 IRYSVPEETERGSFVGNL-AKDlglevGELAArGARV-------VSKGNKQYFQLNPETGDLLLNEKLDREE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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