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Concise Results
Standard Results
Full Results
insulin-degrading enzyme isoform X3 [Gallus gallus]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
33-943
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 915.39
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 33 F L G L QKETNNKMNNPAIKRITNE IIKSP E D K R E YR GLE L A NG I K A LL I SDP TT DKS S AAL D V HI GS LS DP PNIA GL S HF C 112
Cdd:COG1025 12 L L L L LAAAPSAQAAQGWQPLAET IIKSP N D P R Q YR AIT L D NG L K V LL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 113 EHMLFLGTKKYP KEN EY SQ F L S E H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ESCK DRE V NAV DS E H 192
Cdd:COG1025 92 EHMLFLGTKKYP EPG EY QE F I S K H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E Y 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 193 EKNLMN D AW R LF Q LE K A T G NP N HPFS K F GT GN KL TL ETR P tke G IDV R Q ELL K F HST YYS S NLM AICVLGRE SLDEL TS L 272
Cdd:COG1025 172 TLKRSD D GR R IY Q VH K E T L NP A HPFS R F SV GN LE TL SDK P --- G SKL R D ELL A F YQR YYS A NLM KLVLYSNQ SLDEL EK L 248
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 273 VVKL F SEVE N K N VP VP EFPEHPFQE E H L RQLYKV VP I K DI R N L YVT FPIP DL Q K YY K S N P GH Y LGH L I G H EG P GSLL SE L 352
Cdd:COG1025 249 ARQT F GAIP N R N LS VP PITVPLYTP E Q L GIIIHI VP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW L 328
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 353 K AK G WVYT L VG G QKEGA R G F MF F I I N V D LT EE GL L H VED II LHM F Q YI QKL R IE G P QEW V F Q E CKD L NAV AFRF KD K E RP 432
Cdd:COG1025 329 K KQ G LAES L SA G GGISG R N F GD F S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP 408
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 433 RG Y T S K L GGMLHY YP I E E VL A A E YL LEE F R P DL I EMV L DK L R PEN I R VAIV S K sf EGK TD R T ED WY G T Q Y KQEA I SD E VI 512
Cdd:COG1025 409 MD Y V S W L SDNMLR YP V E D VL D A D YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQ E QL 486
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 513 K KWQ N A DL N GKFK LP MK N EF IP TN F EILP L E K DATQ y P A L VK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHC 592
Cdd:COG1025 487 A KWQ Q A SQ N PALS LP EL N PY IP DD F SLIK L D K ESAK - P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQ 565
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 593 NMAY L YLE LL K D S LNE YA Y A A EL AGL N Y D L QNTIY G MY LS VK G YND KQ HI LL KKIIEKM A T FE ID E K RF EII K EAYM R S L 672
Cdd:COG1025 566 VLTR L LDY LL N D A LNE LS Y Q A SV AGL S Y S L YAHQG G LT LS AS G FTQ KQ PK LL EALLDQL A S FE PT E E RF AQA K SQLL R Q L 645
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 673 N N FRAEQ P HQHAMYY L RL L MTEVAWTKD EL KE AL DDV TL PR L K AF IS QLL SR LH I E A L LH GN ITKQA A LGIMQMVEDT L I 752
Cdd:COG1025 646 D N AEKAK P YSQLFSP L SR L LQPPYFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L A 725
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 753 EHAHTKPLLP sqlvry RE V Q L PDR G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLG 832
Cdd:COG1025 726 PNGTGEEPRR ------ QV V D L DKS G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLG 798
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 833 Y I V FS G PRRANGIQ GL R F II QS - EKP P H YL ES R VEA FLK TM E KCIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W G 911
Cdd:COG1025 799 Y V V GA G YMPLGRQP GL G F YV QS p VAS P A YL LE R IDD FLK QF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W V 878
890 900 910
....*....|....*....|....*....|...
gi 2024510397 912 E I ISQQYN FD - R DNI e V A YL K T LT KD D I I Q F YK 943
Cdd:COG1025 879 D I GNGDFE FD t R EKL - I A AV K K LT RA D L I D F FQ 910
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
33-943
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 915.39
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 33 F L G L QKETNNKMNNPAIKRITNE IIKSP E D K R E YR GLE L A NG I K A LL I SDP TT DKS S AAL D V HI GS LS DP PNIA GL S HF C 112
Cdd:COG1025 12 L L L L LAAAPSAQAAQGWQPLAET IIKSP N D P R Q YR AIT L D NG L K V LL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 113 EHMLFLGTKKYP KEN EY SQ F L S E H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ESCK DRE V NAV DS E H 192
Cdd:COG1025 92 EHMLFLGTKKYP EPG EY QE F I S K H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E Y 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 193 EKNLMN D AW R LF Q LE K A T G NP N HPFS K F GT GN KL TL ETR P tke G IDV R Q ELL K F HST YYS S NLM AICVLGRE SLDEL TS L 272
Cdd:COG1025 172 TLKRSD D GR R IY Q VH K E T L NP A HPFS R F SV GN LE TL SDK P --- G SKL R D ELL A F YQR YYS A NLM KLVLYSNQ SLDEL EK L 248
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 273 VVKL F SEVE N K N VP VP EFPEHPFQE E H L RQLYKV VP I K DI R N L YVT FPIP DL Q K YY K S N P GH Y LGH L I G H EG P GSLL SE L 352
Cdd:COG1025 249 ARQT F GAIP N R N LS VP PITVPLYTP E Q L GIIIHI VP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW L 328
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 353 K AK G WVYT L VG G QKEGA R G F MF F I I N V D LT EE GL L H VED II LHM F Q YI QKL R IE G P QEW V F Q E CKD L NAV AFRF KD K E RP 432
Cdd:COG1025 329 K KQ G LAES L SA G GGISG R N F GD F S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP 408
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 433 RG Y T S K L GGMLHY YP I E E VL A A E YL LEE F R P DL I EMV L DK L R PEN I R VAIV S K sf EGK TD R T ED WY G T Q Y KQEA I SD E VI 512
Cdd:COG1025 409 MD Y V S W L SDNMLR YP V E D VL D A D YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQ E QL 486
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 513 K KWQ N A DL N GKFK LP MK N EF IP TN F EILP L E K DATQ y P A L VK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHC 592
Cdd:COG1025 487 A KWQ Q A SQ N PALS LP EL N PY IP DD F SLIK L D K ESAK - P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQ 565
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 593 NMAY L YLE LL K D S LNE YA Y A A EL AGL N Y D L QNTIY G MY LS VK G YND KQ HI LL KKIIEKM A T FE ID E K RF EII K EAYM R S L 672
Cdd:COG1025 566 VLTR L LDY LL N D A LNE LS Y Q A SV AGL S Y S L YAHQG G LT LS AS G FTQ KQ PK LL EALLDQL A S FE PT E E RF AQA K SQLL R Q L 645
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 673 N N FRAEQ P HQHAMYY L RL L MTEVAWTKD EL KE AL DDV TL PR L K AF IS QLL SR LH I E A L LH GN ITKQA A LGIMQMVEDT L I 752
Cdd:COG1025 646 D N AEKAK P YSQLFSP L SR L LQPPYFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L A 725
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 753 EHAHTKPLLP sqlvry RE V Q L PDR G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLG 832
Cdd:COG1025 726 PNGTGEEPRR ------ QV V D L DKS G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLG 798
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 833 Y I V FS G PRRANGIQ GL R F II QS - EKP P H YL ES R VEA FLK TM E KCIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W G 911
Cdd:COG1025 799 Y V V GA G YMPLGRQP GL G F YV QS p VAS P A YL LE R IDD FLK QF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W V 878
890 900 910
....*....|....*....|....*....|...
gi 2024510397 912 E I ISQQYN FD - R DNI e V A YL K T LT KD D I I Q F YK 943
Cdd:COG1025 879 D I GNGDFE FD t R EKL - I A AV K K LT RA D L I D F FQ 910
PRK15101
PRK15101 protease3; Provisional
1-943
7.92e-148
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 464.45
E-value: 7.92e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 1 M RQRLL tel RR ALL GCARP WA a P T SQ fa PQR G FLG LQ k ET nnkmnnpaikritne I I KS PE D K R E Y RGLE L A NG IKA LL I 80
Cdd:PRK15101 1 M PRSTW --- FK ALL LLLAL WA - P L SQ -- AET G WQP LQ - ET --------------- I R KS EK D P R Q Y QAIR L D NG MTV LL V 58
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 81 SDP TTD KS S AAL DVHI GSL S DP PNIA GL S H FC EHM LFL G T KKYP KENEYSQ FL SE H A GS S NA F T SGEH T NY Y FD V SHEH L 160
Cdd:PRK15101 59 SDP QAV KS L AAL ALPV GSL E DP DAQQ GL A H YL EHM VLM G S KKYP QPDSLAE FL KK H G GS H NA S T ASYR T AF Y LE V ENDA L 138
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 161 EG A L DR F A QFFLC PL F D ESCK DRE V NAV DS E HEKNLMN D AW R LF Q LEKA T G NP N HP F S K F GT GN klt LET RPT K E G IDVR 240
Cdd:PRK15101 139 PP A V DR L A DAIAE PL L D PKNA DRE R NAV NA E LTMARSR D GM R MA Q VSAE T I NP A HP G S R F SG GN --- LET LSD K P G SKLQ 215
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 241 QE L LK F HST YYS S NLM AICVLGRES L D EL TS L VVKL F SE V E NKN VP VPE FPEHPFQEEHLRQLYKV VP IKDIRN L Y V T F P 320
Cdd:PRK15101 216 DA L VD F YQR YYS A NLM KAVIYSNQP L P EL AK L AADT F GR V P NKN AS VPE ITVPVVTDAQKGIIIHY VP AQPRKV L R V E F R 295
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 321 I PDLQKYYK S NPGH Y LGH LIG HEG PG S L LSE L KAK G wvyt L VG G QKE GA ----- R GFMF F I I N V D LT EE GL LHVEDIILH 395
Cdd:PRK15101 296 I DNNSAKFR S KTDE Y ISY LIG NRS PG T L SDW L QKQ G ---- L AE G ISA GA dpmvd R NSGV F A I S V S LT DK GL AQRDQVVAA 371
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 396 M F Q Y IQK LR IE G PQEWV F Q E CKDLNAVA FR FKDKE R PRG Y TSK L GGMLHYY P I E EV L A A E Y LLEEFR P DL I EMV L DKLR P 475
Cdd:PRK15101 372 I F S Y LNL LR EK G IDKSY F D E LAHVLDLD FR YPSIT R DMD Y IEW L ADTMLRV P V E HT L D A P Y IADRYD P KA I KAR L AEMT P 451
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 476 E N I R VAIV S K sf EGKTDR T EDWYGTQ Y KQEA IS DEVIKK WQ NADL N GKFK LP MK N EF IP TN F EILPLE K d A TQY P A L VK D 555
Cdd:PRK15101 452 Q N A R IWYI S P -- QEPHNK T AYFVDAP Y QVDK IS EQTFAD WQ QKAQ N IALS LP EL N PY IP DD F SLIKAD K - A YKH P E L IV D 528
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 556 T ------ A M SKLW F KQD dkffl PKA CLNFEFFS P F A YVDPLHCNMAY L -- YL EL L kd S L NEYAYA A ELA G LNYDL q N TIY 627
Cdd:PRK15101 529 E pglrvv Y M PSQY F ADE ----- PKA DISLVLRN P K A MDSARNQVLFA L nd YL AG L -- A L DQLSNQ A SVG G ISFST - N ANN 600
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 628 G MYLSVK GY N dk Q HI -- LL KKII E KMAT F EID E KRFEII K EA Y MRS L NNFRAEQPHQH A MYYLRL L MTEVAWTK DE LKEA 705
Cdd:PRK15101 601 G LMVNAN GY T -- Q RL pq LL QALL E GYFS F TPT E EQLAQA K SW Y REQ L DSAEKGKAYEQ A IMPAQM L SQVPYFER DE RRKL 678
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 706 L DDV TL PRLK A FISQ LLS RLHI E A L LH GN I T KQAA lgimqmve D TL IEHAHTK - PLLPSQLV R YRE V QLPDRGWFVYQQR 784
Cdd:PRK15101 679 L PSI TL KDVL A YRDA LLS GATP E F L VV GN L T EEQV -------- T TL ARDVQKQ l GADGTEWW R GKD V VVDKKQSVNFEKA 750
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 785 NEVHNNCGIEI Y YQ T --- DM QS TSENMF L E lfc QII SEPCF N T LRT K EQLGY I VF SG P RRANGIQ G LR F II QS - E K P P H Y 860
Cdd:PRK15101 751 GSSTDSALAAV Y VP T gyd EY QS SAYSSL L G --- QII QPWFY N Q LRT E EQLGY A VF AF P MSVGRQW G MG F LL QS n D K Q P A Y 827
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 861 L ES R VE AF LKTM E KCIED M TE E A F QKHI QAL AIRR L DK P KK L SA E CAKYWGEIISQQYN FD - RD N I e V A YL K T LT KDDII 939
Cdd:PRK15101 828 L WQ R YQ AF FPQA E AKLRA M KP E E F AQYQ QAL INQL L QA P QT L GE E ASRLSKDFDRGNMR FD s RD K I - I A QI K L LT PQKLA 906
....
gi 2024510397 940 Q F YK 943
Cdd:PRK15101 907 D F FH 910
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
424-705
4.57e-131
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 396.94
E-value: 4.57e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 424 FRF KD K ER P RG Y T S K L GGMLHY YP I E EV L AAE YLL E E FR P D LI EMV LD K L R PEN I R VAI VSK S FEG K TD RT E D WYGT Q Y K 503
Cdd:pfam16187 1 FRF QE K SP P SD Y V S S L ASNMQP YP P E DI L SGD YLL R E YD P E LI QEL LD Y L T PEN A R ITL VSK E FEG E TD QK E P WYGT E Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 504 Q E A I SD E VI KKW Q NA - DL N GKFK LP MK N E FIPT N F EILPL E - K DATQ YP A L VK DT AM S K LW F K Q DD K F FL PKA CLNFEFF 581
Cdd:pfam16187 81 V E P I PE E LL KKW K NA p EP N PELH LP EP N P FIPT D F DLKKK E v K EPAK YP V L IR DT PL S R LW Y K K DD T F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 582 SP F AY VD P LHCNMAY LY L ELLKDSLNEYAY A AELAGL N Y D L QN T IY G MY LSV K GYNDK QHI LL K KI I EK MAT FEID EK RF 661
Cdd:pfam16187 161 SP L AY SS P RNAVLTR LY V ELLKDSLNEYAY D AELAGL S Y S L SA T ER G LT LSV S GYNDK LPV LL E KI L EK LRD FEID PD RF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2024510397 662 EIIKE AYM RS LN NF RA EQP H Q H A MY YL RL L MT E VA WT KD E LK EA 705
Cdd:pfam16187 241 EIIKE QLL RS YK NF AL EQP Y Q Q A FD YL LY L LE E RS WT PE E KL EA 284
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
33-943
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 915.39
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 33 F L G L QKETNNKMNNPAIKRITNE IIKSP E D K R E YR GLE L A NG I K A LL I SDP TT DKS S AAL D V HI GS LS DP PNIA GL S HF C 112
Cdd:COG1025 12 L L L L LAAAPSAQAAQGWQPLAET IIKSP N D P R Q YR AIT L D NG L K V LL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 113 EHMLFLGTKKYP KEN EY SQ F L S E H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ESCK DRE V NAV DS E H 192
Cdd:COG1025 92 EHMLFLGTKKYP EPG EY QE F I S K H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E Y 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 193 EKNLMN D AW R LF Q LE K A T G NP N HPFS K F GT GN KL TL ETR P tke G IDV R Q ELL K F HST YYS S NLM AICVLGRE SLDEL TS L 272
Cdd:COG1025 172 TLKRSD D GR R IY Q VH K E T L NP A HPFS R F SV GN LE TL SDK P --- G SKL R D ELL A F YQR YYS A NLM KLVLYSNQ SLDEL EK L 248
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 273 VVKL F SEVE N K N VP VP EFPEHPFQE E H L RQLYKV VP I K DI R N L YVT FPIP DL Q K YY K S N P GH Y LGH L I G H EG P GSLL SE L 352
Cdd:COG1025 249 ARQT F GAIP N R N LS VP PITVPLYTP E Q L GIIIHI VP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW L 328
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 353 K AK G WVYT L VG G QKEGA R G F MF F I I N V D LT EE GL L H VED II LHM F Q YI QKL R IE G P QEW V F Q E CKD L NAV AFRF KD K E RP 432
Cdd:COG1025 329 K KQ G LAES L SA G GGISG R N F GD F S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP 408
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 433 RG Y T S K L GGMLHY YP I E E VL A A E YL LEE F R P DL I EMV L DK L R PEN I R VAIV S K sf EGK TD R T ED WY G T Q Y KQEA I SD E VI 512
Cdd:COG1025 409 MD Y V S W L SDNMLR YP V E D VL D A D YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQ E QL 486
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 513 K KWQ N A DL N GKFK LP MK N EF IP TN F EILP L E K DATQ y P A L VK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHC 592
Cdd:COG1025 487 A KWQ Q A SQ N PALS LP EL N PY IP DD F SLIK L D K ESAK - P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQ 565
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 593 NMAY L YLE LL K D S LNE YA Y A A EL AGL N Y D L QNTIY G MY LS VK G YND KQ HI LL KKIIEKM A T FE ID E K RF EII K EAYM R S L 672
Cdd:COG1025 566 VLTR L LDY LL N D A LNE LS Y Q A SV AGL S Y S L YAHQG G LT LS AS G FTQ KQ PK LL EALLDQL A S FE PT E E RF AQA K SQLL R Q L 645
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 673 N N FRAEQ P HQHAMYY L RL L MTEVAWTKD EL KE AL DDV TL PR L K AF IS QLL SR LH I E A L LH GN ITKQA A LGIMQMVEDT L I 752
Cdd:COG1025 646 D N AEKAK P YSQLFSP L SR L LQPPYFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L A 725
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 753 EHAHTKPLLP sqlvry RE V Q L PDR G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLG 832
Cdd:COG1025 726 PNGTGEEPRR ------ QV V D L DKS G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLG 798
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 833 Y I V FS G PRRANGIQ GL R F II QS - EKP P H YL ES R VEA FLK TM E KCIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W G 911
Cdd:COG1025 799 Y V V GA G YMPLGRQP GL G F YV QS p VAS P A YL LE R IDD FLK QF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W V 878
890 900 910
....*....|....*....|....*....|...
gi 2024510397 912 E I ISQQYN FD - R DNI e V A YL K T LT KD D I I Q F YK 943
Cdd:COG1025 879 D I GNGDFE FD t R EKL - I A AV K K LT RA D L I D F FQ 910
PRK15101
PRK15101 protease3; Provisional
1-943
7.92e-148
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 464.45
E-value: 7.92e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 1 M RQRLL tel RR ALL GCARP WA a P T SQ fa PQR G FLG LQ k ET nnkmnnpaikritne I I KS PE D K R E Y RGLE L A NG IKA LL I 80
Cdd:PRK15101 1 M PRSTW --- FK ALL LLLAL WA - P L SQ -- AET G WQP LQ - ET --------------- I R KS EK D P R Q Y QAIR L D NG MTV LL V 58
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 81 SDP TTD KS S AAL DVHI GSL S DP PNIA GL S H FC EHM LFL G T KKYP KENEYSQ FL SE H A GS S NA F T SGEH T NY Y FD V SHEH L 160
Cdd:PRK15101 59 SDP QAV KS L AAL ALPV GSL E DP DAQQ GL A H YL EHM VLM G S KKYP QPDSLAE FL KK H G GS H NA S T ASYR T AF Y LE V ENDA L 138
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 161 EG A L DR F A QFFLC PL F D ESCK DRE V NAV DS E HEKNLMN D AW R LF Q LEKA T G NP N HP F S K F GT GN klt LET RPT K E G IDVR 240
Cdd:PRK15101 139 PP A V DR L A DAIAE PL L D PKNA DRE R NAV NA E LTMARSR D GM R MA Q VSAE T I NP A HP G S R F SG GN --- LET LSD K P G SKLQ 215
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 241 QE L LK F HST YYS S NLM AICVLGRES L D EL TS L VVKL F SE V E NKN VP VPE FPEHPFQEEHLRQLYKV VP IKDIRN L Y V T F P 320
Cdd:PRK15101 216 DA L VD F YQR YYS A NLM KAVIYSNQP L P EL AK L AADT F GR V P NKN AS VPE ITVPVVTDAQKGIIIHY VP AQPRKV L R V E F R 295
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 321 I PDLQKYYK S NPGH Y LGH LIG HEG PG S L LSE L KAK G wvyt L VG G QKE GA ----- R GFMF F I I N V D LT EE GL LHVEDIILH 395
Cdd:PRK15101 296 I DNNSAKFR S KTDE Y ISY LIG NRS PG T L SDW L QKQ G ---- L AE G ISA GA dpmvd R NSGV F A I S V S LT DK GL AQRDQVVAA 371
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 396 M F Q Y IQK LR IE G PQEWV F Q E CKDLNAVA FR FKDKE R PRG Y TSK L GGMLHYY P I E EV L A A E Y LLEEFR P DL I EMV L DKLR P 475
Cdd:PRK15101 372 I F S Y LNL LR EK G IDKSY F D E LAHVLDLD FR YPSIT R DMD Y IEW L ADTMLRV P V E HT L D A P Y IADRYD P KA I KAR L AEMT P 451
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 476 E N I R VAIV S K sf EGKTDR T EDWYGTQ Y KQEA IS DEVIKK WQ NADL N GKFK LP MK N EF IP TN F EILPLE K d A TQY P A L VK D 555
Cdd:PRK15101 452 Q N A R IWYI S P -- QEPHNK T AYFVDAP Y QVDK IS EQTFAD WQ QKAQ N IALS LP EL N PY IP DD F SLIKAD K - A YKH P E L IV D 528
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 556 T ------ A M SKLW F KQD dkffl PKA CLNFEFFS P F A YVDPLHCNMAY L -- YL EL L kd S L NEYAYA A ELA G LNYDL q N TIY 627
Cdd:PRK15101 529 E pglrvv Y M PSQY F ADE ----- PKA DISLVLRN P K A MDSARNQVLFA L nd YL AG L -- A L DQLSNQ A SVG G ISFST - N ANN 600
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 628 G MYLSVK GY N dk Q HI -- LL KKII E KMAT F EID E KRFEII K EA Y MRS L NNFRAEQPHQH A MYYLRL L MTEVAWTK DE LKEA 705
Cdd:PRK15101 601 G LMVNAN GY T -- Q RL pq LL QALL E GYFS F TPT E EQLAQA K SW Y REQ L DSAEKGKAYEQ A IMPAQM L SQVPYFER DE RRKL 678
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 706 L DDV TL PRLK A FISQ LLS RLHI E A L LH GN I T KQAA lgimqmve D TL IEHAHTK - PLLPSQLV R YRE V QLPDRGWFVYQQR 784
Cdd:PRK15101 679 L PSI TL KDVL A YRDA LLS GATP E F L VV GN L T EEQV -------- T TL ARDVQKQ l GADGTEWW R GKD V VVDKKQSVNFEKA 750
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 785 NEVHNNCGIEI Y YQ T --- DM QS TSENMF L E lfc QII SEPCF N T LRT K EQLGY I VF SG P RRANGIQ G LR F II QS - E K P P H Y 860
Cdd:PRK15101 751 GSSTDSALAAV Y VP T gyd EY QS SAYSSL L G --- QII QPWFY N Q LRT E EQLGY A VF AF P MSVGRQW G MG F LL QS n D K Q P A Y 827
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 861 L ES R VE AF LKTM E KCIED M TE E A F QKHI QAL AIRR L DK P KK L SA E CAKYWGEIISQQYN FD - RD N I e V A YL K T LT KDDII 939
Cdd:PRK15101 828 L WQ R YQ AF FPQA E AKLRA M KP E E F AQYQ QAL INQL L QA P QT L GE E ASRLSKDFDRGNMR FD s RD K I - I A QI K L LT PQKLA 906
....
gi 2024510397 940 Q F YK 943
Cdd:PRK15101 907 D F FH 910
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
424-705
4.57e-131
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 396.94
E-value: 4.57e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 424 FRF KD K ER P RG Y T S K L GGMLHY YP I E EV L AAE YLL E E FR P D LI EMV LD K L R PEN I R VAI VSK S FEG K TD RT E D WYGT Q Y K 503
Cdd:pfam16187 1 FRF QE K SP P SD Y V S S L ASNMQP YP P E DI L SGD YLL R E YD P E LI QEL LD Y L T PEN A R ITL VSK E FEG E TD QK E P WYGT E Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 504 Q E A I SD E VI KKW Q NA - DL N GKFK LP MK N E FIPT N F EILPL E - K DATQ YP A L VK DT AM S K LW F K Q DD K F FL PKA CLNFEFF 581
Cdd:pfam16187 81 V E P I PE E LL KKW K NA p EP N PELH LP EP N P FIPT D F DLKKK E v K EPAK YP V L IR DT PL S R LW Y K K DD T F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 582 SP F AY VD P LHCNMAY LY L ELLKDSLNEYAY A AELAGL N Y D L QN T IY G MY LSV K GYNDK QHI LL K KI I EK MAT FEID EK RF 661
Cdd:pfam16187 161 SP L AY SS P RNAVLTR LY V ELLKDSLNEYAY D AELAGL S Y S L SA T ER G LT LSV S GYNDK LPV LL E KI L EK LRD FEID PD RF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2024510397 662 EIIKE AYM RS LN NF RA EQP H Q H A MY YL RL L MT E VA WT KD E LK EA 705
Cdd:pfam16187 241 EIIKE QLL RS YK NF AL EQP Y Q Q A FD YL LY L LE E RS WT PE E KL EA 284
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
76-213
5.85e-49
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 170.18
E-value: 5.85e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 76 KALLI SDP TT D K S SAA L DVHI GS LSD P P N IA GL S HF C EHM L F L GTKKYP k E NE YSQF L SEHA GS S NAFTS G E H T N YY FD V 155
Cdd:pfam00675 1 RVASE SDP PA D T S TVG L WIDA GS RYE P D N NN GL A HF L EHM A F K GTKKYP - S NE LEEE L EKLG GS L NAFTS R E N T V YY AE V 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024510397 156 SHEH L EG A L DR F A Q FF LC PLF D ES CKD R ------- EV N AVDSE HEK ---- NL MND A W R LFQ L EKATGN P 213
Cdd:pfam00675 80 LNDD L PK A V DR L A D FF RN PLF T ES EIE R erlvvly EV E AVDSE PQL vvle NL HAA A Y R NTP L GRSLLG P 148
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
52-483
2.06e-47
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 175.50
E-value: 2.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 52 ITNEIIKS P EDKREYRGLE L A NG IKAL L IS DP TTDKS S AA L D V HI GS LSD PP NIA GL S HF C EHMLF L GTKK YPK e N E YSQ 131
Cdd:COG0612 1 LAPAAGAA P AAAPDVEEFT L P NG LRVI L VP DP EAPVV S VR L W V RV GS RDE PP GKT GL A HF L EHMLF K GTKK RSA - G E IAE 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 132 F L SEHA GS S NAFTS GEH T N YY FD V SH E H LE G AL DRF A QFF L C P L FDE SCKD RE VNA V DS E HEKNLMNDAWRL F QLEK A TG 211
Cdd:COG0612 80 E L EALG GS L NAFTS FDY T V YY LS V LS E D LE L AL ELL A DRL L N P T FDE EELE RE RGV V LE E IRRYEDDPDGLA F EALL A AL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 212 NPN HP FSKFGT G NKLTL E T rptkeg I D v R QE L LK F HST YY SS N LMAIC V L G RESLD E LTS LV V K L F SEVENKNV P VPEF P 291
Cdd:COG0612 160 YGD HP YGRPII G TEESI E A ------ I T - R ED L RA F YKR YY RP N NAVLV V V G DVDPE E VLA LV E K Y F GDLPAGPA P PRPD P 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 292 EH P F Q EEHL R qly K VV PIK D IR -- NLYVTF P I P DL qkyyk SN P GH Y ---- L GHLI G H e G PG S L L SEL -- KA KG WV Y T l VG 363
Cdd:COG0612 233 AE P P Q TGPR R --- V VV DDP D AE qa HILLGY P G P AR ----- DD P DY Y aldv L NEIL G G - G FS S R L FQE lr EK KG LA Y S - VG 302
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 364 GQKEGA R GFMF F I I NVDLTEEG L LHVEDI IL hmf QYIQK L RI EG PQ E WVFQEC K D -- L NAV A FRF kdk E RPR G YT S K LG G 441
Cdd:COG0612 303 SSFSPY R DAGL F T I YAGTAPDK L EEALAA IL --- EELER L AK EG VT E EELERA K N ql L GSL A LSL --- E SNS G LA S Q LG R 376
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 2024510397 442 MLH Y Y - PIEEVLAAEYLL E EFRPDLIEM V LD K - L R P E N IR V AI V 483
Cdd:COG0612 377 YEL Y G g DLDYLEEYLERI E AVTAEDVQA V AR K y L D P D N LV V VV V 420
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
240-418
7.76e-30
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 116.72
E-value: 7.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 240 R QE L LK F HSTY YS SNL M AICVL G RESLD EL TS L VV K L F SEVENK nv P VPEFPEH P FQEEH L RQLYK VVP I KD IRN -- L YV 317
Cdd:pfam05193 4 R ED L RD F YKKH YS PDN M VLVIV G DVDHE EL LD L AE K Y F GDLPAS -- P KGKPRPP P LEPAK L KGREV VVP K KD EPQ ah L AL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 318 T FP I P D L QKYYK S NPGHY L GH L I G HEGPGS L LS EL KA K - G WV Y TLVGGQKEG a RGFMF F I I NVDLTE E gll H V EDI I LHM 396
Cdd:pfam05193 82 A FP G P P L NNDED S LALDV L NE L L G GGMSSR L FQ EL RE K e G LA Y SVSSFNDSY - SDSGL F G I YATVDP E --- N V DEV I ELI 157
170 180
....*....|....*....|..
gi 2024510397 397 FQYIQ KL RI EG PQ E WVFQEC K D 418
Cdd:pfam05193 158 LEELE KL AQ EG VT E EELERA K N 179
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
708-891
1.06e-15
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 76.28
E-value: 1.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 708 DV T LPR L KA F ISQLL S RLHIEALLH G NITKQAA L gim QMV E DTL ieh AHTKPLLPSQLVRYREVQLPDR G WF V YQQRNEV 787
Cdd:pfam05193 1 SL T RED L RD F YKKHY S PDNMVLVIV G DVDHEEL L --- DLA E KYF --- GDLPASPKGKPRPPPLEPAKLK G RE V VVPKKDE 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510397 788 HNNC g IEIYYQT - DMQSTSENMF L ELFCQIISE ---- PC F NT LR T KE Q L G Y I V F S GPRRAN -- G IQ G LRFIIQS E K pphy 860
Cdd:pfam05193 75 PQAH - LALAFPG p PLNNDEDSLA L DVLNELLGG gmss RL F QE LR E KE G L A Y S V S S FNDSYS ds G LF G IYATVDP E N ---- 149
170 180 190
....*....|....*....|....*....|..
gi 2024510397 861 LESRV E AF L KTM EK - CI E DM TEE AFQKHIQA L 891
Cdd:pfam05193 150 VDEVI E LI L EEL EK l AQ E GV TEE ELERAKNQ L 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
