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Conserved domains on  [gi|2024510585|ref|XP_040531443|]
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potassium voltage-gated channel subfamily H member 7 isoform X3 [Gallus gallus]

Protein Classification

PAS domain-containing protein( domain architecture ID 13822714)

PAS domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03192 super family cl33658
Voltage-dependent potassium channel; Provisional
 379-828 5.47e-36

Voltage-dependent potassium channel; Provisional


The actual alignment was detected with superfamily member PLN03192:

Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 147.71  E-value: 5.47e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  379 WDWLILLLVIYTAIFTPYSAAFLlNDSEERKrrecgyscspLNVVDLIVDIMFIIDILINFRTTYVNQNEEV-VSDPAKI 457
Cdd:PLN03192    64 WETLMVVLVAYSAWVYPFEVAFL-NASPKRG----------LEIADNVVDLFFAVDIVLTFFVAYIDPRTQLlVRDRKKI 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  458 AIHYFKGWFLIDMVAAIPFD---LLIFGSGSEETT-TLIGLLKTARLLRLVRVARKLD---RYSEYGAAVLMLLmCIFAL 530
Cdd:PLN03192   133 AVRYLSTWFLMDVASTIPFQalaYLITGTVKLNLSySLLGLLRFWRLRRVKQLFTRLEkdiRFSYFWIRCARLL-SVTLF 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  531 IAHWLACIWYAIGNverPYLAHKIGWLDSLGEQLGKhynksdassgPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 610
Cdd:PLN03192   212 LVHCAGCLYYLIAD---RYPHQGKTWIGAVIPNFRE----------TSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEM 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  611 IFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNgidMNME-V 689
Cdd:PLN03192   279 IFIIFYMLFNLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAES---LNQQqL 355

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  690 LKGFPECLQADICLHLNQNLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILKSDI-- 767
Cdd:PLN03192   356 IDQLPKSICKSICQHLFLPVVEKVYLFKGVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEIIDSEGek 435

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024510585  768 --VVAILGKNDIFGEMVHLYAKPGKSNADVRALTycDLHKIQREDLLEVLDMYPEFSDLFLTN 828
Cdd:PLN03192   436 erVVGTLGCGDIFGEVGALCCRPQSFTFRTKTLS--QLLRLKTSTLIEAMQTRQEDNVVILKN 496
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 1-84 8.06e-13

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 65.18  E-value: 8.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585    1 MTGFSRPDVMQKPCTcDFLHGPETKRHhiaqIAQAL-LGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEGVAMMFIINF 79
Cdd:pfam13426   14 LLGYTREELLGKSIT-DLFAEPEDSER----LREALrEGKAVREFEVVLYRKDGEPFPVLVSLAPIRDDGGELVGIIAIL 88


                   ....*
gi 2024510585   80 EYVTD 84
Cdd:pfam13426   89 RDITE 93
 
Name Accession Description Interval E-value
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 379-828 5.47e-36

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 147.71  E-value: 5.47e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  379 WDWLILLLVIYTAIFTPYSAAFLlNDSEERKrrecgyscspLNVVDLIVDIMFIIDILINFRTTYVNQNEEV-VSDPAKI 457
Cdd:PLN03192    64 WETLMVVLVAYSAWVYPFEVAFL-NASPKRG----------LEIADNVVDLFFAVDIVLTFFVAYIDPRTQLlVRDRKKI 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  458 AIHYFKGWFLIDMVAAIPFD---LLIFGSGSEETT-TLIGLLKTARLLRLVRVARKLD---RYSEYGAAVLMLLmCIFAL 530
Cdd:PLN03192   133 AVRYLSTWFLMDVASTIPFQalaYLITGTVKLNLSySLLGLLRFWRLRRVKQLFTRLEkdiRFSYFWIRCARLL-SVTLF 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  531 IAHWLACIWYAIGNverPYLAHKIGWLDSLGEQLGKhynksdassgPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 610
Cdd:PLN03192   212 LVHCAGCLYYLIAD---RYPHQGKTWIGAVIPNFRE----------TSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEM 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  611 IFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNgidMNME-V 689
Cdd:PLN03192   279 IFIIFYMLFNLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAES---LNQQqL 355

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  690 LKGFPECLQADICLHLNQNLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILKSDI-- 767
Cdd:PLN03192   356 IDQLPKSICKSICQHLFLPVVEKVYLFKGVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEIIDSEGek 435

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024510585  768 --VVAILGKNDIFGEMVHLYAKPGKSNADVRALTycDLHKIQREDLLEVLDMYPEFSDLFLTN 828
Cdd:PLN03192   436 erVVGTLGCGDIFGEVGALCCRPQSFTFRTKTLS--QLLRLKTSTLIEAMQTRQEDNVVILKN 496
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 378-640 8.37e-36

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 136.24  E-value: 8.37e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  378 VWDWLILLLVIYTAIFTPYSAAFLLNDseerkrrecgYSCSPLNVVDLIVDIMFIIDILINFRTTYvnqneevvsdpakI 457
Cdd:pfam00520    3 YFELFILLLILLNTIFLALETYFQPEE----------PLTTVLEILDYVFTGIFTLEMLLKIIAAG-------------F 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  458 AIHYFK-GWFLIDMVAAIPFdLLIFGSGSEETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL--MLLMCIFALIAHW 534
Cdd:pfam00520   60 KKRYFRsPWNILDFVVVLPS-LISLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLL 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  535 LACIWYAIGNverpylahkigwldslgeQLGKHYNKSDASSGPSIK--DKYVTALYFTFSSLTSVGFGNVSPNTNSEK-- 610
Cdd:pfam00520  139 FLFIFAIIGY------------------QLFGGKLKTWENPDNGRTnfDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKge 200

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2024510585  611 -----IFSICVMLIGSLMYASIFGNVSAIIQRLYS 640
Cdd:pfam00520  201 fwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 715-826 2.44e-23

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 96.24  E-value: 2.44e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  715 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILKSD-----IVVAILGKNDIFGEMVHLYAKPg 789
Cdd:cd00038      1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDedgreQIVGFLGPGDLFGELALLGNGP- 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2024510585  790 kSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDLFL 826
Cdd:cd00038     80 -RSATVRALTDSELLVLPRSDFRRLLQEYPELARRLL 115
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 716-832 1.66e-21

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 90.92  E-value: 1.66e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585   716 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILK-----SDIVVAILGKNDIFGEMVHLYAKPGK 790
Cdd:smart00100    2 FKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKvledgEEQIVGTLGPGDFFGELALLTNSRRA 81

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 2024510585   791 SNADVRALTYCDLHKIQREDLLEvldMYPEFSDLFLTNLELT 832
Cdd:smart00100   82 ASAAAVALELATLLRIDFRDFLQ---LLPELPQLLLELLLEL 120
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 716-830 4.65e-16

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 78.10  E-value: 4.65e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  716 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILKSD-----IVVAILGKNDIFGEMVHLYAKPgk 790
Cdd:COG0664      1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISedgreQILGFLGPGDFFGELSLLGGEP-- 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2024510585  791 SNADVRALTYCDLHKIQREDLLEVLDMYPEFSDLFLTNLE 830
Cdd:COG0664     79 SPATAEALEDSELLRIPREDLEELLERNPELARALLRLLA 118
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 1-84 8.06e-13

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 65.18  E-value: 8.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585    1 MTGFSRPDVMQKPCTcDFLHGPETKRHhiaqIAQAL-LGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEGVAMMFIINF 79
Cdd:pfam13426   14 LLGYTREELLGKSIT-DLFAEPEDSER----LREALrEGKAVREFEVVLYRKDGEPFPVLVSLAPIRDDGGELVGIIAIL 88


                   ....*
gi 2024510585   80 EYVTD 84
Cdd:pfam13426   89 RDITE 93
PAS COG2202
PAS domain [Signal transduction mechanisms];
1-84 2.54e-09

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 59.27  E-value: 2.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585    1 MTGFSRPDVMQKpcTCDFLHGPETKRHHIAQIAQALLGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEGVAMMFIINFE 80
Cdd:COG2202     43 LTGYSAEELLGK--TLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRKDGSLFWVELSISPVRDEDGEITGFVGIAR 120


                   ....
gi 2024510585   81 YVTD 84
Cdd:COG2202    121 DITE 124
PRK13557 PRK13557
histidine kinase; Provisional
 1-70 6.13e-08

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 56.60  E-value: 6.13e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585    1 MTGFSRPDVMQKpcTCDFLHGPETKRHHIAQIAQALLGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEG 70
Cdd:PRK13557    65 MTGYAAEEIIGN--NCRFLQGPETDRATVAEVRDAIAERREIATEILNYRKDGSSFWNALFVSPVYNDAG 132
 
Name Accession Description Interval E-value
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 379-828 5.47e-36

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 147.71  E-value: 5.47e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  379 WDWLILLLVIYTAIFTPYSAAFLlNDSEERKrrecgyscspLNVVDLIVDIMFIIDILINFRTTYVNQNEEV-VSDPAKI 457
Cdd:PLN03192    64 WETLMVVLVAYSAWVYPFEVAFL-NASPKRG----------LEIADNVVDLFFAVDIVLTFFVAYIDPRTQLlVRDRKKI 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  458 AIHYFKGWFLIDMVAAIPFD---LLIFGSGSEETT-TLIGLLKTARLLRLVRVARKLD---RYSEYGAAVLMLLmCIFAL 530
Cdd:PLN03192   133 AVRYLSTWFLMDVASTIPFQalaYLITGTVKLNLSySLLGLLRFWRLRRVKQLFTRLEkdiRFSYFWIRCARLL-SVTLF 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  531 IAHWLACIWYAIGNverPYLAHKIGWLDSLGEQLGKhynksdassgPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 610
Cdd:PLN03192   212 LVHCAGCLYYLIAD---RYPHQGKTWIGAVIPNFRE----------TSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEM 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  611 IFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNgidMNME-V 689
Cdd:PLN03192   279 IFIIFYMLFNLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAES---LNQQqL 355

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  690 LKGFPECLQADICLHLNQNLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILKSDI-- 767
Cdd:PLN03192   356 IDQLPKSICKSICQHLFLPVVEKVYLFKGVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEIIDSEGek 435

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024510585  768 --VVAILGKNDIFGEMVHLYAKPGKSNADVRALTycDLHKIQREDLLEVLDMYPEFSDLFLTN 828
Cdd:PLN03192   436 erVVGTLGCGDIFGEVGALCCRPQSFTFRTKTLS--QLLRLKTSTLIEAMQTRQEDNVVILKN 496
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 378-640 8.37e-36

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 136.24  E-value: 8.37e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  378 VWDWLILLLVIYTAIFTPYSAAFLLNDseerkrrecgYSCSPLNVVDLIVDIMFIIDILINFRTTYvnqneevvsdpakI 457
Cdd:pfam00520    3 YFELFILLLILLNTIFLALETYFQPEE----------PLTTVLEILDYVFTGIFTLEMLLKIIAAG-------------F 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  458 AIHYFK-GWFLIDMVAAIPFdLLIFGSGSEETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL--MLLMCIFALIAHW 534
Cdd:pfam00520   60 KKRYFRsPWNILDFVVVLPS-LISLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLL 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  535 LACIWYAIGNverpylahkigwldslgeQLGKHYNKSDASSGPSIK--DKYVTALYFTFSSLTSVGFGNVSPNTNSEK-- 610
Cdd:pfam00520  139 FLFIFAIIGY------------------QLFGGKLKTWENPDNGRTnfDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKge 200

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2024510585  611 -----IFSICVMLIGSLMYASIFGNVSAIIQRLYS 640
Cdd:pfam00520  201 fwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 715-826 2.44e-23

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 96.24  E-value: 2.44e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  715 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILKSD-----IVVAILGKNDIFGEMVHLYAKPg 789
Cdd:cd00038      1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDedgreQIVGFLGPGDLFGELALLGNGP- 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2024510585  790 kSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDLFL 826
Cdd:cd00038     80 -RSATVRALTDSELLVLPRSDFRRLLQEYPELARRLL 115
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 716-832 1.66e-21

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 90.92  E-value: 1.66e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585   716 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILK-----SDIVVAILGKNDIFGEMVHLYAKPGK 790
Cdd:smart00100    2 FKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKvledgEEQIVGTLGPGDFFGELALLTNSRRA 81

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 2024510585   791 SNADVRALTYCDLHKIQREDLLEvldMYPEFSDLFLTNLELT 832
Cdd:smart00100   82 ASAAAVALELATLLRIDFRDFLQ---LLPELPQLLLELLLEL 120
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 716-830 4.65e-16

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 78.10  E-value: 4.65e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  716 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILKSD-----IVVAILGKNDIFGEMVHLYAKPgk 790
Cdd:COG0664      1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISedgreQILGFLGPGDFFGELSLLGGEP-- 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2024510585  791 SNADVRALTYCDLHKIQREDLLEVLDMYPEFSDLFLTNLE 830
Cdd:COG0664     79 SPATAEALEDSELLRIPREDLEELLERNPELARALLRLLA 118
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 1-84 8.06e-13

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 65.18  E-value: 8.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585    1 MTGFSRPDVMQKPCTcDFLHGPETKRHhiaqIAQAL-LGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEGVAMMFIINF 79
Cdd:pfam13426   14 LLGYTREELLGKSIT-DLFAEPEDSER----LREALrEGKAVREFEVVLYRKDGEPFPVLVSLAPIRDDGGELVGIIAIL 88


                   ....*
gi 2024510585   80 EYVTD 84
Cdd:pfam13426   89 RDITE 93
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 735-818 1.03e-12

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 64.94  E-value: 1.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  735 HAPPGDTLVHCGDVLTALYFVSRGSIEILKSD-----IVVAILGKNDIFGEMVHLYAKPgkSNADVRALTYCDLHKIQRE 809
Cdd:pfam00027    3 SYKAGEVIFREGDPADSLYIVLSGKVKVYRTLedgreQILAVLGPGDFFGELALLGGEP--RSATVVALTDSELLVIPRE 80


                   ....*....
gi 2024510585  810 DLLEVLDMY 818
Cdd:pfam00027   81 DFLELLERD 89
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 583-637 5.86e-11

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 59.59  E-value: 5.86e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024510585  583 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQR 637
Cdd:pfam07885   24 FLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
737-841 1.52e-09

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 59.22  E-value: 1.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  737 PPGDTLVHCGDVLTALYFVSRGSIEILKSD-----IVVAILGKNDIFGEMvHLYAKPGKSNADVRALTYCDLHKIQREDL 811
Cdd:PRK11753    26 PAKSTLIHAGEKAETLYYIVKGSVAVLIKDeegkeMILSYLNQGDFIGEL-GLFEEGQERSAWVRAKTACEVAEISYKKF 104

                           90       100       110
                   ....*....|....*....|....*....|
gi 2024510585  812 LEVLDMYPEFsdLFLTNLELTFNLRDETAK 841
Cdd:PRK11753   105 RQLIQVNPDI--LMALSAQMARRLQNTSRK 132
PAS COG2202
PAS domain [Signal transduction mechanisms];
1-84 2.54e-09

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 59.27  E-value: 2.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585    1 MTGFSRPDVMQKpcTCDFLHGPETKRHHIAQIAQALLGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEGVAMMFIINFE 80
Cdd:COG2202     43 LTGYSAEELLGK--TLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRKDGSLFWVELSISPVRDEDGEITGFVGIAR 120


                   ....
gi 2024510585   81 YVTD 84
Cdd:COG2202    121 DITE 124
PRK13557 PRK13557
histidine kinase; Provisional
 1-70 6.13e-08

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 56.60  E-value: 6.13e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585    1 MTGFSRPDVMQKpcTCDFLHGPETKRHHIAQIAQALLGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEG 70
Cdd:PRK13557    65 MTGYAAEEIIGN--NCRFLQGPETDRATVAEVRDAIAERREIATEILNYRKDGSSFWNALFVSPVYNDAG 132
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 1-70 1.17e-06

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 52.92  E-value: 1.17e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585    1 MTGFSRPDVMQKpcTCDFLHGPETKRHHIAQIAQALLGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEG 70
Cdd:PRK13558   183 ITGYSPDEVLGR--NCRFLQGEDTNEERVAELREAIDEERPTSVELRNYRKDGSTFWNQVDIAPIRDEDG 250
PRK13559 PRK13559
hypothetical protein; Provisional
 1-75 3.07e-06

hypothetical protein; Provisional


Pssm-ID: 237427 [Multi-domain]  Cd Length: 361  Bit Score: 50.97  E-value: 3.07e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024510585    1 MTGFSRPDVMQKpcTCDFLHGPETKRHHIAQIAQALLGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEGVAMMF 75
Cdd:PRK13559    78 LTGYAAEEVVGR--NCRFLQGAATDPIAVAKIRAAIAAEREIVVELLNYRKDGEPFWNALHLGPVYGEDGRLLYF 150
PRK10537 PRK10537
voltage-gated potassium channel protein;
458-656 5.24e-05

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 46.94  E-value: 5.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  458 AIHYFKGWfLIDMVAAIPFDLLI----FGSGSEETTTLIGLLKTAR-------LLRLVRVARKLDRYSE------YGAAV 520
Cdd:PRK10537    39 ALNLFDIW-HIKALSALDLSLLAnapqFMLGVFLVLMAIGLLFRARlawaisiLLLLAALAITLHFYPWlkfligYCIVL 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024510585  521 LMLLMC--------------IFALIAhWLACIWYAIgnverpylahkigwLDSLgeQLGKHYNksdassgPSIKDkYVTA 586
Cdd:PRK10537   118 LVALLIyrrdfdrsslaagtLFAVIS-ITSLLFYST--------------FGAL--YLGDGFS-------PPIES-LSTA 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024510585  587 LYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYA----SIFGNV-SAIIQRLYSGTARyhmQMLRVKEFI 656
Cdd:PRK10537   173 FYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFAtsisAIFGPViRGNLKRLVKGRIS---HMHRKDHFI 244
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
1-77 3.92e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 40.99  E-value: 3.92e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024510585    1 MTGFSRPDVMQKPCTcDFLHGPETKRHHIAQIAQAllGSEERKVEVTYYHKDGSTFICNTHIIPVKNQEGVAMMFII 77
Cdd:COG3852     39 LLGLSAEELLGRPLA-ELFPEDSPLRELLERALAE--GQPVTEREVTLRRKDGEERPVDVSVSPLRDAEGEGGVLLV 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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