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Conserved domains on  [gi|2024518742|ref|XP_040535172|]
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YEATS domain-containing protein 2 isoform X4 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 208-331 1.88e-85

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


:

Pssm-ID: 341126  Cd Length: 123  Bit Score: 273.68  E-value: 1.88e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  208 KTIVVGNVSKYIPPDKREeNDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16907      1 KRIIVGNVSKYIPPDERE-DDKSTHKWMVYVRGPPEDPDIDHFVKKVRFFLHPSYAPNDVVEVTKPPFHLTRRGWGEFPV 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2024518742  288 RVQIHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHR 331
Cdd:cd16907     80 RVQLHFKDPRNKPVDIIHNLKLDRTYTGLQTLGAETVVDVELDR 123
MIT_CorA-like super family cl00459
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 26-160 7.72e-03

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


The actual alignment was detected with superfamily member cd11744:

Pssm-ID: 469776 [Multi-domain]  Cd Length: 286  Bit Score: 39.88  E-value: 7.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742   26 RHRAAEQSARD-----IAVQKIETIIkEQFAVEMKNKEHEIEVID------------QRLIEARRMMDKLRACIVANYYA 88
Cdd:cd11744     90 RQRLREHSKGPksaasLLNQLIEGLN-GKIDLYLETIEETLNELDvndeeghydestYNHIALQKALISIRRFIRPQQYA 168

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024518742   89 SAGLLKPgegtrscdatilnhpsikkflESPSRSSSPaHQGSDApsanHSESDSLSQHNDFFLDKDSGSLDA 160
Cdd:cd11744    169 LRDLIRS---------------------ESELVTSRP-HQYRFA----HNNITRINETIEFYLGEVALLQDE 214
 
Name Accession Description Interval E-value
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 208-331 1.88e-85

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341126  Cd Length: 123  Bit Score: 273.68  E-value: 1.88e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  208 KTIVVGNVSKYIPPDKREeNDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16907      1 KRIIVGNVSKYIPPDERE-DDKSTHKWMVYVRGPPEDPDIDHFVKKVRFFLHPSYAPNDVVEVTKPPFHLTRRGWGEFPV 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2024518742  288 RVQIHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHR 331
Cdd:cd16907     80 RVQLHFKDPRNKPVDIIHNLKLDRTYTGLQTLGAETVVDVELDR 123
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 231-310 6.25e-36

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 130.65  E-value: 6.25e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  231 THKWMVYVRGSRREPsINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRRGWGEFPVRVQIHFKDSQNKRIDIIHNLKLD 310
Cdd:pfam03366    2 THKWTVYVRGLDNED-ISYFIKKVVFKLHPSF-ANPVRVVKKPPFEVTETGWGEFEIRIKIYFKDKDEKPVTIYHDLKLH 79
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
201-337 8.24e-17

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 81.00  E-value: 8.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  201 TSRLYVKKTIVVGNVsKYIPPDKREENDQsTHKWMVYVRGSRREpSINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRR 280
Cdd:COG5033      7 TERLKTQRVIIPGEA-KPLGNEERFPVRH-THIWLVFVRAPGKE-DIATIVKKVIFKLHPTF-SNPTRTIESPPFEIKET 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024518742  281 GWGEFPVRVQIHFKDSQN-KRIDIIHNLKLDrtytglqTLGAETVVDVELHRHSLGEE 337
Cdd:COG5033     83 GWGEFDIQIKIFFAEKAGeKTIHFYLHFGDE-------PYAVDEPVDIPVNRPDLTSE 133
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 26-160 7.72e-03

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 39.88  E-value: 7.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742   26 RHRAAEQSARD-----IAVQKIETIIkEQFAVEMKNKEHEIEVID------------QRLIEARRMMDKLRACIVANYYA 88
Cdd:cd11744     90 RQRLREHSKGPksaasLLNQLIEGLN-GKIDLYLETIEETLNELDvndeeghydestYNHIALQKALISIRRFIRPQQYA 168

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024518742   89 SAGLLKPgegtrscdatilnhpsikkflESPSRSSSPaHQGSDApsanHSESDSLSQHNDFFLDKDSGSLDA 160
Cdd:cd11744    169 LRDLIRS---------------------ESELVTSRP-HQYRFA----HNNITRINETIEFYLGEVALLQDE 214
 
Name Accession Description Interval E-value
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 208-331 1.88e-85

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341126  Cd Length: 123  Bit Score: 273.68  E-value: 1.88e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  208 KTIVVGNVSKYIPPDKREeNDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16907      1 KRIIVGNVSKYIPPDERE-DDKSTHKWMVYVRGPPEDPDIDHFVKKVRFFLHPSYAPNDVVEVTKPPFHLTRRGWGEFPV 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2024518742  288 RVQIHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHR 331
Cdd:cd16907     80 RVQLHFKDPRNKPVDIIHNLKLDRTYTGLQTLGAETVVDVELDR 123
YEATS cd16887
YEATS domain family, chromatin reader proteins; The YEATS family is named for several family ...
 208-332 1.49e-42

YEATS domain family, chromatin reader proteins; The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein, YEATS2, Drosophila D12, and others. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones.


Pssm-ID: 341123  Cd Length: 120  Bit Score: 151.28  E-value: 1.49e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  208 KTIVVGNVSKYIPPDKREENdqsTHKWMVYVRGSRREPsINHFVKKVWFFLHPSYKPNdLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16887      1 KPIVIGNVAEKIPKPEPDDN---THKWTVYVRSPTNED-LSSFIKKVTFKLHPSFPNP-VRVVTDPPFEVEEVGWGEFPI 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2024518742  288 RVQIHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRH 332
Cdd:cd16887     76 EIKIYFKDSNEKPVTLSHFLKLHPDGSPLKKPVVVSEKYDEIVFR 120
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 231-310 6.25e-36

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 130.65  E-value: 6.25e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  231 THKWMVYVRGSRREPsINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRRGWGEFPVRVQIHFKDSQNKRIDIIHNLKLD 310
Cdd:pfam03366    2 THKWTVYVRGLDNED-ISYFIKKVVFKLHPSF-ANPVRVVKKPPFEVTETGWGEFEIRIKIYFKDKDEKPVTIYHDLKLH 79
YEATS_TFIID14_like cd16910
YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; ...
 206-309 4.18e-29

YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; YEATS domain containing proteins, which include Transcription initiation factor TFIID subunits 14 and 14b of Arabidopsis, shown to be part of the TFIID general transcriptional regulator complex in a two-hybrid screen. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341129  Cd Length: 131  Bit Score: 113.44  E-value: 4.18e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  206 VKKTIVVGNVSKYIPPDKREENdqsTHKWMVYVRGSRREpSINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRRGWGEF 285
Cdd:cd16910      1 VSVPIVYGSIAFWLGKKADETH---THKWTVYVRGANNE-DLSYFIKKVVFVLHPSF-ANPTRVVTEPPFEVTETGWGEF 75

                           90       100
                   ....*....|....*....|....
gi 2024518742  286 PVRVQIHFKDSQNKRIDIIHNLKL 309
Cdd:cd16910     76 EIGITIHFKDDAEKPVELTHPLKL 99
YEATS_GAS41_like cd16909
YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified ...
 208-326 6.29e-28

YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified sequence 41 (GAS41, also known as, YEATS domain-containing protein 4, NuMA-binding protein 1 ) is a YEATS domain family protein that is amplified and acts as an oncogene in human glioma. GAS41 is a YEATS domain family protein and has been shown to interact with the general transcription factor TFIIF via the YEATS domain. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341128  Cd Length: 137  Bit Score: 110.03  E-value: 6.29e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  208 KTIVVGNVSKYIPPdKREEnDQSTHKWMVYVRGSRREpSINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRRGWGEFPV 287
Cdd:cd16909      5 KPIVYGNIARYFGK-KREE-DGHTHQWTVYVKPYFNE-DMSTYVKKVQFKLHESY-ANPLRVVTKPPYEVTETGWGEFEI 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2024518742  288 RVQIHFKDSQNKRIDIIHNLKLDRTYTGLqTLGAETVVD 326
Cdd:cd16909     81 IIKIFFIDPNERPVTLYHLLKLFQSDTNL-MLGKKTLVS 118
YEATS_Yaf9_like cd16908
YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein ...
 206-309 1.56e-24

YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein essential in the function the NuA4 histone acetyltransferase complex and the SWR1-C ATP-dependent chromatin remodeling complex. Yaf9 shares structural similarity with histone chaperone Asf1, both exhibit histone H3 and H4 binding in vitro, and evidence supports both play a role in the same histone acetylation mechanism. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: `YNK7', `ENL', `AF-9', and `TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341127  Cd Length: 145  Bit Score: 100.82  E-value: 1.56e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  206 VKKTIVVGNVSKYIPPDKREENDQS-THKWMVYVRGSRREpSINHFVKKVWFFLHPSYK-PNDLVEvrEPPFHLTRRGWG 283
Cdd:cd16908      2 VSRPIVYGNTARPLTPEEKPKAPPDhTHKWTVFVRGPDGE-DLSYFIKKVVFKLHESYPnPNRTIE--KPPFEVTETGWG 78

                           90       100
                   ....*....|....*....|....*..
gi 2024518742  284 EFPVRVQIHFKD-SQNKRIDIIHNLKL 309
Cdd:cd16908     79 EFEIQIKIYFVPeANEKPITLYHMLKL 105
YEATS_AF-9_like cd16906
YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that ...
 231-309 6.13e-18

YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that binds to modified histones, with a preference for crotonyllysine over acetyllysine. Histone crotonylation upregulates gene expression in an AF9-dependent manner. Sub-family also includes eleven-nineteen-leukemia protein ENL, which binds histones H3 and H1. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341125  Cd Length: 127  Bit Score: 81.08  E-value: 6.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  231 THKWMVYVRGSRREPsINHFVKKVWFFLHPSYKPNDLVeVREPPFHLTRRGWGEFPVRVQIHFKDSQN-KRIDIIHNLKL 309
Cdd:cd16906     21 THDWTVFVRGANGSD-ISHFVEKVVFHLHESFPKPKRV-VKEPPFEVTESGYAGFTLPIEIYFKNKEEpKKVRFEYDLFL 98
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
201-337 8.24e-17

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 81.00  E-value: 8.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  201 TSRLYVKKTIVVGNVsKYIPPDKREENDQsTHKWMVYVRGSRREpSINHFVKKVWFFLHPSYkPNDLVEVREPPFHLTRR 280
Cdd:COG5033      7 TERLKTQRVIIPGEA-KPLGNEERFPVRH-THIWLVFVRAPGKE-DIATIVKKVIFKLHPTF-SNPTRTIESPPFEIKET 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024518742  281 GWGEFPVRVQIHFKDSQN-KRIDIIHNLKLDrtytglqTLGAETVVDVELHRHSLGEE 337
Cdd:COG5033     83 GWGEFDIQIKIFFAEKAGeKTIHFYLHFGDE-------PYAVDEPVDIPVNRPDLTSE 133
YEATS_Taf14_like cd16905
YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of ...
 206-307 2.06e-11

YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of TFIIF and TFIID transcription factor complexes, various chromatin-remodeling complexes (such as SWI/SNF, INO80, and RSC) and the NuA3 histone acetyltransferase complex. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. Specifically, Taf14 has been show to be a reader of lysine crotonylation, associated with active gene promoters and enhancers and binding acetyllysine on in histone H3. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341124  Cd Length: 118  Bit Score: 62.20  E-value: 2.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742  206 VKKTIVVgNVSKYIPPDKREENDQSTHKW---MVYVRGSRREPSINHFvKKVWFFLHPSY-KPNdlVEVREPPFHLTRRG 281
Cdd:cd16905      1 VKRTIRI-KTQQHILPDVPPVEGFPLRKWsieLVLLDPNGEEVPADIF-DKVTYHLHPTFeNPI--RTFKKPPFRLEEKG 76

                           90       100
                   ....*....|....*....|....*.
gi 2024518742  282 WGEFPVRVQIHFKDSQNKRIdIIHNL 307
Cdd:cd16905     77 WGEFDMKIVLHFLDNGGEFT-ITHDL 101
pYEATS pfam20305
prokaryotic YEATS domain; This entry represents a prokaryotic YEATS domain. pYEATS is fused to ...
 233-307 1.23e-10

prokaryotic YEATS domain; This entry represents a prokaryotic YEATS domain. pYEATS is fused to diverse effector domains, suggesting that the binding to a ligand activates an effector-based response against an invasive threat. It has been predicted to specifically recognize invader-induced modifications of macromolecules by acyl moieties (e.g. phage-encoded acylations of surface polysaccharides) to unleash the fused effectors through a conformational change.


Pssm-ID: 466455  Cd Length: 73  Bit Score: 58.45  E-value: 1.23e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024518742  233 KWMVYVRGSRREPSinhFVKKVWFFLHPSYKPNDL-VEVREPPFHLTRRGWGEFPVRVQIHFKDSQNKRIDiiHNL 307
Cdd:pfam20305    2 DVRLWVDGPDPVLL---LIESVEYTLHPTFPNPVRtVTDRNGNFSLSLSAWGAFTVGAEVEFKDGGEIELE--RYL 72
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 26-160 7.72e-03

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 39.88  E-value: 7.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518742   26 RHRAAEQSARD-----IAVQKIETIIkEQFAVEMKNKEHEIEVID------------QRLIEARRMMDKLRACIVANYYA 88
Cdd:cd11744     90 RQRLREHSKGPksaasLLNQLIEGLN-GKIDLYLETIEETLNELDvndeeghydestYNHIALQKALISIRRFIRPQQYA 168

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024518742   89 SAGLLKPgegtrscdatilnhpsikkflESPSRSSSPaHQGSDApsanHSESDSLSQHNDFFLDKDSGSLDA 160
Cdd:cd11744    169 LRDLIRS---------------------ESELVTSRP-HQYRFA----HNNITRINETIEFYLGEVALLQDE 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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