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Conserved domains on  [gi|2024518962|ref|XP_040535276|]
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dynein assembly factor with WDR repeat domains 1 isoform X3 [Gallus gallus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
87-378 5.37e-99

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 299.52  E-value: 5.37e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  87 VLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSTET 166
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 167 GKCYHTFRGHTAEIghsaeiVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTGSMD 246
Cdd:COG2319   194 GKLLRTLTGHTGAV------RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 247 KTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNRILT 326
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2024518962 327 ASSDKTARLWDAATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVW 378
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
87-378 5.37e-99

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 299.52  E-value: 5.37e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  87 VLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSTET 166
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 167 GKCYHTFRGHTAEIghsaeiVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTGSMD 246
Cdd:COG2319   194 GKLLRTLTGHTGAV------RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 247 KTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNRILT 326
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2024518962 327 ASSDKTARLWDAATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVW 378
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-378 1.26e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 256.11  E-value: 1.26e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  84 LFKVLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWS 163
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 164 TETGKCYHTFRGHTAEIghsaeiVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTG 243
Cdd:cd00200    80 LETGECVRTLTGHTSYV------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 244 SMDKTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNR 323
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2024518962 324 ILTASSDKTARLWDAATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVW 378
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 135-379 1.00e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.81  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 135 NVVYAIAFNNPyGDKIATGSFDKTCKLWSTET----GKCYHTfrgHTAEIGHSAEIVALSFNT-TGDRIITGSFDCTVGV 209
Cdd:PLN00181  484 NLVCAIGFDRD-GEFFATAGVNKKIKIFECESiikdGRDIHY---PVVELASRSKLSGICWNSyIKSQVASSNFEGVVQV 559

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 210 WDVVTGRMLHVLIGHRGEISSAQF-NWDCSLIVTGSMDKTCMLWNATTGAHIATLTGHSDeIMDVCF-DYAGQRIATASA 287
Cdd:PLN00181  560 WDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFpSESGRSLAFGSA 638

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 288 DGSGRVYNAETKKC-IAKLEGHGGEISKICFnPKGNRILTASSDKTARLWD---AATG---HCLQILEGHTDEIFSCAFN 360
Cdd:PLN00181  639 DHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDlsmSISGineTPLHSFMGHTNVKNFVGLS 717

                         250
                  ....*....|....*....
gi 2024518962 361 YKGNIIITGSKDNTCRVWH 379
Cdd:PLN00181  718 VSDGYIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 340-379 4.38e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 4.38e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2024518962  340 TGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVWH 379
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
341-378 2.49e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.49e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2024518962 341 GHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVW 378
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
87-378 5.37e-99

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 299.52  E-value: 5.37e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  87 VLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSTET 166
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 167 GKCYHTFRGHTAEIghsaeiVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTGSMD 246
Cdd:COG2319   194 GKLLRTLTGHTGAV------RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 247 KTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNRILT 326
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2024518962 327 ASSDKTARLWDAATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVW 378
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
87-379 3.84e-96

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 292.20  E-value: 3.84e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  87 VLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSTET 166
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 167 GKCYHTFRGHTAEIghsaeiVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTGSMD 246
Cdd:COG2319   152 GKLLRTLTGHSGAV------TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 247 KTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNRILT 326
Cdd:COG2319   226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2024518962 327 ASSDKTARLWDAATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVWH 379
Cdd:COG2319   306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
87-378 5.17e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 261.38  E-value: 5.17e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  87 VLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFnNPYGDKIATGSFDKTCKLWSTET 166
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 167 GKCYHTFRGHTaeighsAEIVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTGSMD 246
Cdd:COG2319   110 GLLLRTLTGHT------GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 247 KTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNRILT 326
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2024518962 327 ASSDKTARLWDAATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVW 378
Cdd:COG2319   264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-378 1.26e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 256.11  E-value: 1.26e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  84 LFKVLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWS 163
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 164 TETGKCYHTFRGHTAEIghsaeiVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTG 243
Cdd:cd00200    80 LETGECVRTLTGHTSYV------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 244 SMDKTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNR 323
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2024518962 324 ILTASSDKTARLWDAATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVW 378
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
86-340 1.28e-83

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 260.23  E-value: 1.28e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  86 KVLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSTE 165
Cdd:COG2319   156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PDGKLLASGSADGTVRLWDLA 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 166 TGKCYHTFRGHTAEIGhsaeivALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTGSM 245
Cdd:COG2319   235 TGKLLRTLTGHSGSVR------SVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 246 DKTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNRIL 325
Cdd:COG2319   309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                         250
                  ....*....|....*
gi 2024518962 326 TASSDKTARLWDAAT 340
Cdd:COG2319   389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-337 8.26e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 228.37  E-value: 8.26e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  84 LFKVLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWS 163
Cdd:cd00200    43 LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWD 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 164 TETGKCYHTFRGHTAEIghsaeiVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTG 243
Cdd:cd00200   122 VETGKCLTTLRGHTDWV------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 244 SMDKTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNR 323
Cdd:cd00200   196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275

                         250
                  ....*....|....
gi 2024518962 324 ILTASSDKTARLWD 337
Cdd:cd00200   276 LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
84-298 2.43e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.54  E-value: 2.43e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  84 LFKVLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFnNPYGDKIATGSFDKTCKLWS 163
Cdd:COG2319   196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRLWD 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 164 TETGKCYHTFRGHTaeighsAEIVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTG 243
Cdd:COG2319   275 LATGELLRTLTGHS------GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG 348

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2024518962 244 SMDKTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAET 298
Cdd:COG2319   349 SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
147-378 3.70e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.96  E-value: 3.70e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 147 GDKIATGSFDKTCKLWSTETGKCYHTFRGHtaeighSAEIVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRG 226
Cdd:COG2319     6 GAALAAASADLALALLAAALGALLLLLLGL------AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 227 EISSAQFNWDCSLIVTGSMDKTCMLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLE 306
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024518962 307 GHGGEISKICFNPKGNRILTASSDKTARLWDAATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVW 378
Cdd:COG2319   160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
190-379 5.26e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 5.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 190 SFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTGSMDKTCMLWNATTGAHIATLTGHSDE 269
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 270 IMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNRILTASSDKTARLWDAATGHCLQILEG 349
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 2024518962 350 HTDEIFSCAFNYKGNIIITGSKDNTCRVWH 379
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-253 4.22e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 4.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  81 KFYLFKVLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFnNPYGDKIATGSFDKTCK 160
Cdd:cd00200   124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIK 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 161 LWSTETGKCYHTFRGHTaeighsAEIVALSFNTTGDRIITGSFDCTVGVWDVVTGRMLHVLIGHRGEISSAQFNWDCSLI 240
Cdd:cd00200   203 LWDLSTGKCLGTLRGHE------NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                         170
                  ....*....|...
gi 2024518962 241 VTGSMDKTCMLWN 253
Cdd:cd00200   277 ASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 259-379 4.16e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.53  E-value: 4.16e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 259 HIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPKGNRILTASSDKTARLWDA 338
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2024518962 339 ATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVWH 379
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-211 4.92e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 4.92e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962  35 LSPHTDVIALVEeIQKEEPLITASCKEHVIRLVqrlqeklgekEDHKFYLFKVLRAHILPLTNVAFNKSGSCFITGSYDR 114
Cdd:cd00200   131 LRGHTDWVNSVA-FSPDGTFVASSSQDGTIKLW----------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 115 TCKVWDTASGEELHTLEGHKNVVYAIAFnNPYGDKIATGSFDKTCKLWSTETGKCYHTFRGHTaeighsAEIVALSFNTT 194
Cdd:cd00200   200 TIKLWDLSTGKCLGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT------NSVTSLAWSPD 272

                         170
                  ....*....|....*..
gi 2024518962 195 GDRIITGSFDCTVGVWD 211
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 135-379 1.00e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.81  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 135 NVVYAIAFNNPyGDKIATGSFDKTCKLWSTET----GKCYHTfrgHTAEIGHSAEIVALSFNT-TGDRIITGSFDCTVGV 209
Cdd:PLN00181  484 NLVCAIGFDRD-GEFFATAGVNKKIKIFECESiikdGRDIHY---PVVELASRSKLSGICWNSyIKSQVASSNFEGVVQV 559

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 210 WDVVTGRMLHVLIGHRGEISSAQF-NWDCSLIVTGSMDKTCMLWNATTGAHIATLTGHSDeIMDVCF-DYAGQRIATASA 287
Cdd:PLN00181  560 WDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFpSESGRSLAFGSA 638

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 288 DGSGRVYNAETKKC-IAKLEGHGGEISKICFnPKGNRILTASSDKTARLWD---AATG---HCLQILEGHTDEIFSCAFN 360
Cdd:PLN00181  639 DHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDlsmSISGineTPLHSFMGHTNVKNFVGLS 717

                         250
                  ....*....|....*....
gi 2024518962 361 YKGNIIITGSKDNTCRVWH 379
Cdd:PLN00181  718 VSDGYIATGSETNEVFVYH 736
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 109-335 7.74e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 66.65  E-value: 7.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 109 TGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWSTETGKCYHTfrghtaeIGHSAEIVA 188
Cdd:PLN00181  550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGT-------IKTKANICC 622

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 189 LSF-NTTGDRIITGSFDCTVGVWDVVTGRM-LHVLIGHRGEISSAQFnWDCSLIVTGSMDKTCMLWNATTGAH------I 260
Cdd:PLN00181  623 VQFpSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpL 701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 261 ATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNA-----------ETKKCIAKLEGHGGE--ISKICFNPKGNRILTA 327
Cdd:PLN00181  702 HSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKafpmpvlsykfKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAA 781


                  ....*...
gi 2024518962 328 SSDKTARL 335
Cdd:PLN00181  782 NSTGNIKI 789
PTZ00421 PTZ00421
coronin; Provisional
 263-377 7.49e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 63.37  E-value: 7.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 263 LTGHSDEIMDVCFD-YAGQRIATASADGS--GRVYNAE--TKKC---IAKLEGHGGEISKICFNPKGNRIL-TASSDKTA 333
Cdd:PTZ00421   71 LLGQEGPIIDVAFNpFDPQKLFTASEDGTimGWGIPEEglTQNIsdpIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVV 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2024518962 334 RLWDAATGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRV 377
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 340-379 4.38e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 4.38e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2024518962  340 TGHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVWH 379
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 298-337 4.69e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 4.69e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2024518962  298 TKKCIAKLEGHGGEISKICFNPKGNRILTASSDKTARLWD 337
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
341-378 2.49e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.49e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2024518962 341 GHCLQILEGHTDEIFSCAFNYKGNIIITGSKDNTCRVW 378
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
299-337 1.20e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2024518962 299 KKCIAKLEGHGGEISKICFNPKGNRILTASSDKTARLWD 337
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-163 1.24e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024518962  123 SGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWS 163
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 220-368 2.09e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.59  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 220 VLIGHRGEISSAQFN-WDCSLIVTGSMDKTCMLWN-------ATTGAHIATLTGHSDEIMDVCFD-YAGQRIATASADGS 290
Cdd:PTZ00421   70 ILLGQEGPIIDVAFNpFDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHpSAMNVLASAGADMV 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024518962 291 GRVYNAETKKCIAKLEGHGGEISKICFNPKGNRILTASSDKTARLWDAATGHCLQILEGH-TDEIFSCAFNYKGNIIIT 368
Cdd:PTZ00421  150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHaSAKSQRCLWAKRKDLIIT 228
WD40 pfam00400
WD domain, G-beta repeat;
124-163 4.36e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 4.36e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2024518962 124 GEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWS 163
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 214-253 1.25e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.25e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2024518962  214 TGRMLHVLIGHRGEISSAQFNWDCSLIVTGSMDKTCMLWN 253
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 132-248 1.86e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 132 GHKNVVYAIAFNnPYGD-KIATGSFDKTCKLWSTETGKCYHTFRGHTAEI-GHSAEIVALSFNTTGDRII-TGSFDCTVG 208
Cdd:PTZ00421   73 GQEGPIIDVAFN-PFDPqKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLqGHTKKVGIVSFHPSAMNVLaSAGADMVVN 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2024518962 209 VWDVVTGRMLHVLIGHRGEISSAQFNWDCSLIVTGSMDKT 248
Cdd:PTZ00421  152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKK 191
WD40 pfam00400
WD domain, G-beta repeat;
215-253 3.13e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.13e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2024518962 215 GRMLHVLIGHRGEISSAQFNWDCSLIVTGSMDKTCMLWN 253
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 166-211 3.94e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 3.94e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2024518962  166 TGKCYHTFRGHTAEIghsaeiVALSFNTTGDRIITGSFDCTVGVWD 211
Cdd:smart00320   1 SGELLKTLKGHTGPV------TSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 256-295 7.03e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.03e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2024518962  256 TGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYN 295
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-120 9.26e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 9.26e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024518962   86 KVLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWD 120
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
167-211 2.14e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2024518962 167 GKCYHTFRGHTAEIghsaeiVALSFNTTGDRIITGSFDCTVGVWD 211
Cdd:pfam00400   1 GKLLKTLEGHTGSV------TSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 180-371 2.43e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 180 IGHSAEIVALSFNTTGD-RIITGSFDCTVGVWDV--------VTGRMLHvLIGHRGEISSAQFNWDC-SLIVTGSMDKTC 249
Cdd:PTZ00421   72 LGQEGPIIDVAFNPFDPqKLFTASEDGTIMGWGIpeegltqnISDPIVH-LQGHTKKVGIVSFHPSAmNVLASAGADMVV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 250 MLWNATTGAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYNAETKKCIAKLEGHGGEISKICFNPK-GNRILTAS 328
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKrKDLIITLG 230

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2024518962 329 SDKT----ARLWDAatghclQILEG--HTDEI-FSCA-----FNYKGNIIITGSK 371
Cdd:PTZ00421  231 CSKSqqrqIMLWDT------RKMASpySTVDLdQSSAlfipfFDEDTNLLYIGSK 279
WD40 pfam00400
WD domain, G-beta repeat;
86-120 2.48e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2024518962  86 KVLRAHILPLTNVAFNKSGSCFITGSYDRTCKVWD 120
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
257-295 5.90e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 5.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2024518962 257 GAHIATLTGHSDEIMDVCFDYAGQRIATASADGSGRVYN 295
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 282-354 1.22e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.34  E-value: 1.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024518962 282 IATASADGSGRVYNAETKKCI-AKLEGHGGEISKICFNPKGNRILTASSDKTARLWDAATGHCLQILEGHTDEI 354
Cdd:pfam12894  10 IALATEDGELLLHRLNWQRVWtLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 150-263 1.53e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.06  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024518962 150 IATGSFDKTCKLWSTETGKCYHTFRGHTaeighsaEIVA-LSFNTTGDRIITGSFDCTVGVWDVVTGRM----------- 217
Cdd:pfam20426  97 ISCGNWENSFQVISLNDGRMVQSIRQHK-------DVVScVAVTSDGSILATGSYDTTVMVWEVLRGRSsekrsrntqte 169

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024518962 218 ------------LHVLIGHRGEISSAQFNWDCSLIVTGSMDKTCMLWNATTGAHIATL 263
Cdd:pfam20426 170 fprkdhviaetpFHILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSI 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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