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Conserved domains on  [gi|2024454188|ref|XP_040537722|]
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DDB1- and CUL4-associated factor 1 isoform X2 [Gallus gallus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1089-1286 3.01e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 3.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1089 ESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSatwsqplsalwgmksvfdm 1168
Cdd:cd00200     51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSS------------------- 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1169 khsfpddqyvefskhSQDRVIgtkgdiaHIYDIQTGNKLLTL-FNPDLAnnykkNCATFNPTDDLVL---NDGV--LWDV 1242
Cdd:cd00200    112 ---------------SRDKTI-------KVWDVETGKCLTTLrGHTDWV-----NSVAFSPDGTFVAsssQDGTikLWDL 164

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1243 RSAQAIHKFDKFNMTISGV-FHPNGLEVIVNTE-----IWDLRTFHLLHT 1286
Cdd:cd00200    165 RTGKCVATLTGHTGEVNSVaFSPDGEKLLSSSSdgtikLWDLSTGKCLGT 214
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1089-1286 3.01e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 3.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1089 ESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSatwsqplsalwgmksvfdm 1168
Cdd:cd00200     51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSS------------------- 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1169 khsfpddqyvefskhSQDRVIgtkgdiaHIYDIQTGNKLLTL-FNPDLAnnykkNCATFNPTDDLVL---NDGV--LWDV 1242
Cdd:cd00200    112 ---------------SRDKTI-------KVWDVETGKCLTTLrGHTDWV-----NSVAFSPDGTFVAsssQDGTikLWDL 164

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1243 RSAQAIHKFDKFNMTISGV-FHPNGLEVIVNTE-----IWDLRTFHLLHT 1286
Cdd:cd00200    165 RTGKCVATLTGHTGEVNSVaFSPDGEKLLSSSSdgtikLWDLSTGKCLGT 214
WD40 COG2319
WD40 repeat [General function prediction only];
1093-1286 1.24e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1093 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSAT------WS----QPLSALWG- 1161
Cdd:COG2319    166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAdgtvrlWDlatgKLLRTLTGh 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1162 MKSVFDMkhSF-PDDQYVefskhsqdrVIGTKGDIAHIYDIQTGNKLLTLfnpdLANNYKKNCATFNPTDDLVL---NDG 1237
Cdd:COG2319    246 SGSVRSV--AFsPDGRLL---------ASGSADGTVRLWDLATGELLRTL----TGHSGGVNSVAFSPDGKLLAsgsDDG 310

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024454188 1238 V--LWDVRSAQAIHKFDKFNMTISGV-FHPNGLEVIV----NT-EIWDLRTFHLLHT 1286
Cdd:COG2319    311 TvrLWDLATGKLLRTLTGHTGAVRSVaFSPDGKTLASgsddGTvRLWDLATGELLRT 367
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1089-1286 3.01e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 3.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1089 ESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSatwsqplsalwgmksvfdm 1168
Cdd:cd00200     51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSS------------------- 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1169 khsfpddqyvefskhSQDRVIgtkgdiaHIYDIQTGNKLLTL-FNPDLAnnykkNCATFNPTDDLVL---NDGV--LWDV 1242
Cdd:cd00200    112 ---------------SRDKTI-------KVWDVETGKCLTTLrGHTDWV-----NSVAFSPDGTFVAsssQDGTikLWDL 164

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1243 RSAQAIHKFDKFNMTISGV-FHPNGLEVIVNTE-----IWDLRTFHLLHT 1286
Cdd:cd00200    165 RTGKCVATLTGHTGEVNSVaFSPDGEKLLSSSSdgtikLWDLSTGKCLGT 214
WD40 COG2319
WD40 repeat [General function prediction only];
1093-1286 1.24e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1093 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSAT------WS----QPLSALWG- 1161
Cdd:COG2319    166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAdgtvrlWDlatgKLLRTLTGh 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1162 MKSVFDMkhSF-PDDQYVefskhsqdrVIGTKGDIAHIYDIQTGNKLLTLfnpdLANNYKKNCATFNPTDDLVL---NDG 1237
Cdd:COG2319    246 SGSVRSV--AFsPDGRLL---------ASGSADGTVRLWDLATGELLRTL----TGHSGGVNSVAFSPDGKLLAsgsDDG 310

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024454188 1238 V--LWDVRSAQAIHKFDKFNMTISGV-FHPNGLEVIV----NT-EIWDLRTFHLLHT 1286
Cdd:COG2319    311 TvrLWDLATGKLLRTLTGHTGAVRSVaFSPDGKTLASgsddGTvRLWDLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
1093-1289 1.35e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 1.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1093 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSAT------WS----QPLSALWG- 1161
Cdd:COG2319    124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDdgtvrlWDlatgKLLRTLTGh 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1162 MKSVFDMkhSF-PDDQYVefskhsqdrVIGTKGDIAHIYDIQTGNKLLTLFNPDLANnykkNCATFNPTDDLVL---NDG 1237
Cdd:COG2319    204 TGAVRSV--AFsPDGKLL---------ASGSADGTVRLWDLATGKLLRTLTGHSGSV----RSVAFSPDGRLLAsgsADG 268

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1238 V--LWDVRSAQAIHKFDKFNMTISGV-FHPNGLEVIVNTE-----IWDLRTFHLLHTVPA 1289
Cdd:COG2319    269 TvrLWDLATGELLRTLTGHSGGVNSVaFSPDGKLLASGSDdgtvrLWDLATGKLLRTLTG 328
WD40 COG2319
WD40 repeat [General function prediction only];
1038-1288 8.50e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 8.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1038 QRRQAPTNFTSRLTRRAAFPKYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYN 1117
Cdd:COG2319     27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1118 VFSGQEEASYNCHNSAITHLEPSRDGSLLLTSAT------WS----QPLSALWGMK-SVFDMkhSF-PDDQYVefskhsq 1185
Cdd:COG2319    107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAdgtvrlWDlatgKLLRTLTGHSgAVTSV--AFsPDGKLL------- 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1186 drVIGTKGDIAHIYDIQTGNKLLTLfnpdLANNYKKNCATFNPTDDLVL---NDGV--LWDVRSAQAIHKFDKFNMTISG 1260
Cdd:COG2319    178 --ASGSDDGTVRLWDLATGKLLRTL----TGHTGAVRSVAFSPDGKLLAsgsADGTvrLWDLATGKLLRTLTGHSGSVRS 251

                          250       260       270
                   ....*....|....*....|....*....|....
gi 2024454188 1261 V-FHPNGLEVIVNTE-----IWDLRTFHLLHTVP 1288
Cdd:COG2319    252 VaFSPDGRLLASGSAdgtvrLWDLATGELLRTLT 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1089-1289 4.02e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 4.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1089 ESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSatwsqplsalwgmksvfdm 1168
Cdd:cd00200     93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS------------------- 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1169 khsfpddqyvefskhSQDRVIgtkgdiaHIYDIQTGnKLLTLFnpdLANNYKKNCATFNPTDDLVL---NDGV--LWDVR 1243
Cdd:cd00200    154 ---------------SQDGTI-------KLWDLRTG-KCVATL---TGHTGEVNSVAFSPDGEKLLsssSDGTikLWDLS 207

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024454188 1244 SAQAIHKFDKFNMTISGV-FHPNGLEVIV-----NTEIWDLRTFHLLHTVPA 1289
Cdd:cd00200    208 TGKCLGTLRGHENGVNSVaFSPDGYLLASgsedgTIRVWDLRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
1088-1280 8.85e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 8.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1088 DESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSatwsqplsalwgmksvfd 1167
Cdd:COG2319    245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG------------------ 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1168 mkhsfpddqyvefskhSQDRVIgtkgdiaHIYDIQTGNKLLTLfnpdLANNYKKNCATFNPTDDLVL---NDGV--LWDV 1242
Cdd:COG2319    307 ----------------SDDGTV-------RLWDLATGKLLRTL----TGHTGAVRSVAFSPDGKTLAsgsDDGTvrLWDL 359

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2024454188 1243 RSAQAIHKFDKFNMTISGV-FHPNGLEVIV----NT-EIWDLRT 1280
Cdd:COG2319    360 ATGELLRTLTGHTGAVTSVaFSPDGRTLASgsadGTvRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1062-1178 1.41e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454188 1062 VDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSR 1141
Cdd:cd00200    150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2024454188 1142 DGSLLLTSAT------WS----QPLSALWG-MKSVFDMKHSfPDDQYV 1178
Cdd:cd00200    230 DGYLLASGSEdgtirvWDlrtgECVQTLSGhTNSVTSLAWS-PDGKRL 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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