NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2024454292|ref|XP_040537773|]
View 

acylamino-acid-releasing enzyme isoform X3 [Gallus gallus]

Protein Classification

alpha/beta hydrolase; alpha/beta hydrolase family protein( domain architecture ID 1908131)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad| alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
421-665 4.55e-45

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


:

Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 160.57  E-value: 4.55e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 421 EALLLSPTGGTtPHPLVVCPHGGPHAVFDArWRPSMAALCWLGFAVLLVNYRGslgFGQAsieclQSRVGEQDVADTQLA 500
Cdd:COG1506    11 PGWLYLPADGK-KYPVVVYVHGGPGSRDDS-FLPLAQALASRGYAVLAPDYRG---YGES-----AGDWGGDEVDDVLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 501 VEQALRYESLDPHRVALLAGSHGAFIALHLLTRQPERYQACALRNPVSNLPALLGTSDipDWRYTSLGLPYsfqrvprvE 580
Cdd:COG1506    81 IDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTR--EYTERLMGGPW--------E 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 581 DLVVMLQRSPIIQAPRVRAPVLLCVGARDRRVSPTQALELYRVLRAHRVPTRLLWYPEGGHALTGVEmEADVFGNCARWF 660
Cdd:COG1506   151 DPEAYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAG-APDYLERILDFL 229


                  ....*
gi 2024454292 661 LQHLG 665
Cdd:COG1506   230 DRHLK 234
APEH_N super family cl44717
Acylamino-acid-releasing enzyme, N-terminal domain; This entry represents the N-terminal ...
 56-271 2.09e-18

Acylamino-acid-releasing enzyme, N-terminal domain; This entry represents the N-terminal region from the Acylamino-acid-releasing enzyme (EC:3.4.19.1). The protein is involved in removing the N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. This domain does not represent the catalytic domain which is found at the C-terminus of these proteins.


The actual alignment was detected with superfamily member pfam19283:

Pssm-ID: 466026  Cd Length: 274  Bit Score: 85.77  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292  56 CSQPDLP---RRRLLrFSRHYSVQRTeHGLTVSRAALSTEIHNRLLGQDSPSGQRRAVlVR-----CPLRghelLEVWdG 127
Cdd:pfam19283  41 ISQPNLLankKRKFI-LSSHISKESD-NSVNFQWAPFPIEMTGVSLIVPSPSGSKLLV-VRnpendSPTK----LEIW-G 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 128 SGH-------SHSVdltalgkHGVVYTEGPFACLAWSHLETQLLYVAEK---SRPTLpaacpGHVPEAARPAEDEDE--- 194
Cdd:pfam19283 113 SSQlekefhiPQSV-------HGSVYTDGWFEGISWNSDETLIAYVAEEpspSKPTF-----GDLGYKKGGSSEKDCgsw 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 195 --EGErfvYHEGWGERLNTRSAPVLYMLDIKSSSVSVLESVPEHVSPGQALWSP----GDTGVVLVGWWHEPFRLGLSAC 268
Cdd:pfam19283 181 kgQGD---WEEDWGETYAGKRQPALFVIDINSGEVQAVKGIPKSLSVGQVVWAPssegSDQYLVFVGWSSDPRKLGIKYC 257


                  ...
gi 2024454292 269 SNR 271
Cdd:pfam19283 258 YNR 260
TolB super family cl43285
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 268-350 1.89e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG0823:

Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 268 CSNR--RSGIFHLELASGHCELLSAPNRASFSPRLSPDGQHLLYLEGAVGGPHrqclqlrldLLLVDTETATVTNLTAGS 345
Cdd:COG0823    48 TSDRggGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSRSDGRFD---------IYVLDLDGGAPRRLTDGP 118


                  ....*
gi 2024454292 346 PEGCW 350
Cdd:COG0823   119 GSPSW 123
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
421-665 4.55e-45

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 160.57  E-value: 4.55e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 421 EALLLSPTGGTtPHPLVVCPHGGPHAVFDArWRPSMAALCWLGFAVLLVNYRGslgFGQAsieclQSRVGEQDVADTQLA 500
Cdd:COG1506    11 PGWLYLPADGK-KYPVVVYVHGGPGSRDDS-FLPLAQALASRGYAVLAPDYRG---YGES-----AGDWGGDEVDDVLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 501 VEQALRYESLDPHRVALLAGSHGAFIALHLLTRQPERYQACALRNPVSNLPALLGTSDipDWRYTSLGLPYsfqrvprvE 580
Cdd:COG1506    81 IDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTR--EYTERLMGGPW--------E 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 581 DLVVMLQRSPIIQAPRVRAPVLLCVGARDRRVSPTQALELYRVLRAHRVPTRLLWYPEGGHALTGVEmEADVFGNCARWF 660
Cdd:COG1506   151 DPEAYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAG-APDYLERILDFL 229


                  ....*
gi 2024454292 661 LQHLG 665
Cdd:COG1506   230 DRHLK 234
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
451-665 1.53e-23

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 99.23  E-value: 1.53e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 451 RWRPSMAALcwLGFAVLLVNYRGSLGFGQASIECLQSRVGEQDVADtQLAVEQALRYESL-DPHRVALLAGSHGAFIALH 529
Cdd:pfam00326   4 SWNAQLLAD--RGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDD-FIAAAEYLIEQGYtDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 530 LLTRQPERYQACALRNPVSNLPALLGTSDIP-DWRYTSLGLPysfqrvprVEDLVVMLQRSPIIQAPRVRA--PVLLCVG 606
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSDTSLPfTERYMEWGNP--------WDNEEGYDYLSPYSPADNVKVypPLLLIHG 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024454292 607 ARDRRVSPTQALELYRVLRAHRVPTRLLWYPEGGHAL----TGVEMEADVFGncarWFLQHLG 665
Cdd:pfam00326 153 LLDDRVPPWQSLKLVAALQRKGVPFLLLIFPDEGHGIgkprNKVEEYARELA----FLLEYLG 211
APEH_N pfam19283
Acylamino-acid-releasing enzyme, N-terminal domain; This entry represents the N-terminal ...
 56-271 2.09e-18

Acylamino-acid-releasing enzyme, N-terminal domain; This entry represents the N-terminal region from the Acylamino-acid-releasing enzyme (EC:3.4.19.1). The protein is involved in removing the N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. This domain does not represent the catalytic domain which is found at the C-terminus of these proteins.


Pssm-ID: 466026  Cd Length: 274  Bit Score: 85.77  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292  56 CSQPDLP---RRRLLrFSRHYSVQRTeHGLTVSRAALSTEIHNRLLGQDSPSGQRRAVlVR-----CPLRghelLEVWdG 127
Cdd:pfam19283  41 ISQPNLLankKRKFI-LSSHISKESD-NSVNFQWAPFPIEMTGVSLIVPSPSGSKLLV-VRnpendSPTK----LEIW-G 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 128 SGH-------SHSVdltalgkHGVVYTEGPFACLAWSHLETQLLYVAEK---SRPTLpaacpGHVPEAARPAEDEDE--- 194
Cdd:pfam19283 113 SSQlekefhiPQSV-------HGSVYTDGWFEGISWNSDETLIAYVAEEpspSKPTF-----GDLGYKKGGSSEKDCgsw 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 195 --EGErfvYHEGWGERLNTRSAPVLYMLDIKSSSVSVLESVPEHVSPGQALWSP----GDTGVVLVGWWHEPFRLGLSAC 268
Cdd:pfam19283 181 kgQGD---WEEDWGETYAGKRQPALFVIDINSGEVQAVKGIPKSLSVGQVVWAPssegSDQYLVFVGWSSDPRKLGIKYC 257


                  ...
gi 2024454292 269 SNR 271
Cdd:pfam19283 258 YNR 260
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 268-350 1.89e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 268 CSNR--RSGIFHLELASGHCELLSAPNRASFSPRLSPDGQHLLYLEGAVGGPHrqclqlrldLLLVDTETATVTNLTAGS 345
Cdd:COG0823    48 TSDRggGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSRSDGRFD---------IYVLDLDGGAPRRLTDGP 118


                  ....*
gi 2024454292 346 PEGCW 350
Cdd:COG0823   119 GSPSW 123
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
421-665 4.55e-45

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 160.57  E-value: 4.55e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 421 EALLLSPTGGTtPHPLVVCPHGGPHAVFDArWRPSMAALCWLGFAVLLVNYRGslgFGQAsieclQSRVGEQDVADTQLA 500
Cdd:COG1506    11 PGWLYLPADGK-KYPVVVYVHGGPGSRDDS-FLPLAQALASRGYAVLAPDYRG---YGES-----AGDWGGDEVDDVLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 501 VEQALRYESLDPHRVALLAGSHGAFIALHLLTRQPERYQACALRNPVSNLPALLGTSDipDWRYTSLGLPYsfqrvprvE 580
Cdd:COG1506    81 IDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTR--EYTERLMGGPW--------E 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 581 DLVVMLQRSPIIQAPRVRAPVLLCVGARDRRVSPTQALELYRVLRAHRVPTRLLWYPEGGHALTGVEmEADVFGNCARWF 660
Cdd:COG1506   151 DPEAYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAG-APDYLERILDFL 229


                  ....*
gi 2024454292 661 LQHLG 665
Cdd:COG1506   230 DRHLK 234
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
451-665 1.53e-23

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 99.23  E-value: 1.53e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 451 RWRPSMAALcwLGFAVLLVNYRGSLGFGQASIECLQSRVGEQDVADtQLAVEQALRYESL-DPHRVALLAGSHGAFIALH 529
Cdd:pfam00326   4 SWNAQLLAD--RGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDD-FIAAAEYLIEQGYtDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 530 LLTRQPERYQACALRNPVSNLPALLGTSDIP-DWRYTSLGLPysfqrvprVEDLVVMLQRSPIIQAPRVRA--PVLLCVG 606
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSDTSLPfTERYMEWGNP--------WDNEEGYDYLSPYSPADNVKVypPLLLIHG 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024454292 607 ARDRRVSPTQALELYRVLRAHRVPTRLLWYPEGGHAL----TGVEMEADVFGncarWFLQHLG 665
Cdd:pfam00326 153 LLDDRVPPWQSLKLVAALQRKGVPFLLLIFPDEGHGIgkprNKVEEYARELA----FLLEYLG 211
APEH_N pfam19283
Acylamino-acid-releasing enzyme, N-terminal domain; This entry represents the N-terminal ...
 56-271 2.09e-18

Acylamino-acid-releasing enzyme, N-terminal domain; This entry represents the N-terminal region from the Acylamino-acid-releasing enzyme (EC:3.4.19.1). The protein is involved in removing the N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. This domain does not represent the catalytic domain which is found at the C-terminus of these proteins.


Pssm-ID: 466026  Cd Length: 274  Bit Score: 85.77  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292  56 CSQPDLP---RRRLLrFSRHYSVQRTeHGLTVSRAALSTEIHNRLLGQDSPSGQRRAVlVR-----CPLRghelLEVWdG 127
Cdd:pfam19283  41 ISQPNLLankKRKFI-LSSHISKESD-NSVNFQWAPFPIEMTGVSLIVPSPSGSKLLV-VRnpendSPTK----LEIW-G 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 128 SGH-------SHSVdltalgkHGVVYTEGPFACLAWSHLETQLLYVAEK---SRPTLpaacpGHVPEAARPAEDEDE--- 194
Cdd:pfam19283 113 SSQlekefhiPQSV-------HGSVYTDGWFEGISWNSDETLIAYVAEEpspSKPTF-----GDLGYKKGGSSEKDCgsw 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 195 --EGErfvYHEGWGERLNTRSAPVLYMLDIKSSSVSVLESVPEHVSPGQALWSP----GDTGVVLVGWWHEPFRLGLSAC 268
Cdd:pfam19283 181 kgQGD---WEEDWGETYAGKRQPALFVIDINSGEVQAVKGIPKSLSVGQVVWAPssegSDQYLVFVGWSSDPRKLGIKYC 257


                  ...
gi 2024454292 269 SNR 271
Cdd:pfam19283 258 YNR 260
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 422-664 2.76e-15

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 76.11  E-value: 2.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 422 ALLLSPTGGTTPHPLVVCPHGGP-----HAVFdARWrpsMAALcwlGFAVLLVNYRGslgFGQASIEClqSRVGEQDVAD 496
Cdd:COG1073    25 GDLYLPAGASKKYPAVVVAHGNGgvkeqRALY-AQR---LAEL---GFNVLAFDYRG---YGESEGEP--REEGSPERRD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 497 TQLAVEQALRYESLDPHRVALLAGSHGAFIALHLLTRQPeRYQACALRNPVSNLPALLGTSDIPDWRYTSLGLPYsfqrV 576
Cdd:COG1073    93 ARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDP-RVKAVILDSPFTSLEDLAAQRAKEARGAYLPGVPY----L 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 577 PRVEDLVVMLQR-SPIIQAPRVRAPVLLCVGARDRRVSPTQALELYRVLRAhrvPTRLLWYPEGGHALTGVEMEADVFGN 655
Cdd:COG1073   168 PNVRLASLLNDEfDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAE---PKELLIVPGAGHVDLYDRPEEEYFDK 244


                  ....*....
gi 2024454292 656 CARWFLQHL 664
Cdd:COG1073   245 LAEFFKKNL 253
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
415-644 3.21e-13

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 69.61  E-value: 3.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 415 HNPQPFEALLLSPTGGTtPHPLVVCPHG----GPHAVFDARWrpsMAALcwlGFAVLLVNYRGSLGFGQASIEC--LQSR 488
Cdd:COG0412    11 PDGVTLPGYLARPAGGG-PRPGVVVLHEifglNPHIRDVARR---LAAA---GYVVLAPDLYGRGGPGDDPDEAraLMGA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 489 VG-EQDVADTQLAVEQALRYESLDPHRVALLAGSHGAFIALHLLTRQPeRYQACALRNPVSNLPALLGTsdipdwrytsl 567
Cdd:COG0412    84 LDpELLAADLRAALDWLKAQPEVDAGRVGVVGFCFGGGLALLAAARGP-DLAAAVSFYGGLPADDLLDL----------- 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024454292 568 glpysfqrvprvedlvvmlqrspiiqAPRVRAPVLLCVGARDRRVSPTQALELYRVLRAHRVPTRLLWYPEGGHALT 644
Cdd:COG0412   152 --------------------------AARIKAPVLLLYGEKDPLVPPEQVAALEAALAAAGVDVELHVYPGAGHGFT 202
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
432-660 7.97e-13

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 68.10  E-value: 7.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 432 TPHPLVVCPHG-GPHAvfdARWRPSMAALCWLGFAVLLVNYRGslgFGQASIEclqsRVGEQDVADTQLAVEQALRYESL 510
Cdd:COG2267    26 SPRGTVVLVHGlGEHS---GRYAELAEALAAAGYAVLAFDLRG---HGRSDGP----RGHVDSFDDYVDDLRAALDALRA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 511 DPH-RVALLAGSHGAFIALHLLTRQPERYQACALrnpvsnlpalLGTSDIPDwrytslglPYSFQRVPRVEDLVVMLQrs 589
Cdd:COG2267    96 RPGlPVVLLGHSMGGLIALLYAARYPDRVAGLVL----------LAPAYRAD--------PLLGPSARWLRALRLAEA-- 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024454292 590 piiqAPRVRAPVLLCVGARDRRVSPTQALELYRVLRAHrvpTRLLWYPEGGHALTGVEMEADVFGNCARWF 660
Cdd:COG2267   156 ----LARIDVPVLVLHGGADRVVPPEAARRLAARLSPD---VELVLLPGARHELLNEPAREEVLAAILAWL 219
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
424-665 2.69e-10

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 60.66  E-value: 2.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 424 LLSPTGGTTPHPLVVCPHGGPHAVFDAR-WRPSMAALC-WLGFAVLLVNYRgslgfgqasieclqsRVGE-------QDV 494
Cdd:COG0657     3 VYRPAGAKGPLPVVVYFHGGGWVSGSKDtHDPLARRLAaRAGAAVVSVDYR---------------LAPEhpfpaalEDA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 495 AD-TQLAVEQALRYeSLDPHRVALLAGSHGAFIALHLLTRQPERY----QACALRNPVSNLPALLGTSDIPdwrytslGL 569
Cdd:COG0657    68 YAaLRWLRANAAEL-GIDPDRIAVAGDSAGGHLAAALALRARDRGgprpAAQVLIYPVLDLTASPLRADLA-------GL 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 570 PysfqrvprvedlvvmlqrspiiqaprvraPVLLCVGARDRRVSptQALELYRVLRAHRVPTRLLWYPEGGHA---LTGV 646
Cdd:COG0657   140 P-----------------------------PTLIVTGEADPLVD--ESEALAAALRAAGVPVELHVYPGGGHGfglLAGL 188

                         250
                  ....*....|....*....
gi 2024454292 647 EMEADVFGNCARWFLQHLG 665
Cdd:COG0657   189 PEARAALAEIAAFLRRALA 207
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 435-643 5.34e-10

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 60.01  E-value: 5.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 435 PLVVCPHGGPHAVFDarWRPSMAALCwLGFAVLLVNYRGslgFGQASieclqSRVGEQDVADTQLAVEQALryESLDPHR 514
Cdd:COG0596    24 PPVVLLHGLPGSSYE--WRPLIPALA-AGYRVIAPDLRG---HGRSD-----KPAGGYTLDDLADDLAALL--DALGLER 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 515 VALLAGSHGAFIALHLLTRQPERYQACALrnpvsnlpallgTSDIPDWRYTSLGLPYsfQRVPRVEDLVVMLQRSPIIQA 594
Cdd:COG0596    91 VVLVGHSMGGMVALELAARHPERVAGLVL------------VDEVLAALAEPLRRPG--LAPEALAALLRALARTDLRER 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2024454292 595 -PRVRAPVLLCVGARDRRVSPTQALELYRVLRAhrvpTRLLWYPEGGHAL 643
Cdd:COG0596   157 lARITVPTLVIWGEKDPIVPPALARRLAELLPN----AELVVLPGAGHFP 202
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 433-643 1.54e-09

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 58.77  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 433 PHPLVVCPHG-GPHAvfdARWRPSMAALCWLGFAVLLVNYRGslgFGQAsiECLQSRVGEQD--VADTQLAVEQALRYES 509
Cdd:pfam12146   3 PRAVVVLVHGlGEHS---GRYAHLADALAAQGFAVYAYDHRG---HGRS--DGKRGHVPSFDdyVDDLDTFVDKIREEHP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 510 LDPhrVALLAGSHGAFIALHLLTRQPERYQACALRNP--------VSNLPALLGT---SDIPDWRYTSLGLPYSFQRVPR 578
Cdd:pfam12146  75 GLP--LFLLGHSMGGLIAALYALRYPDKVDGLILSAPalkikpylAPPILKLLAKllgKLFPRLRVPNNLLPDSLSRDPE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 579 V-----ED-LVV----------MLQRSPIIQ--APRVRAPVLLCVGARDRRVSPTQALELYRvlRAHRVPTRLLWYPEGG 640
Cdd:pfam12146 153 VvaayaADpLVHggisartlyeLLDAGERLLrrAAAITVPLLLLHGGADRVVDPAGSREFYE--RAGSTDKTLKLYPGLY 230


                  ...
gi 2024454292 641 HAL 643
Cdd:pfam12146 231 HEL 233
YpfH COG0400
Predicted esterase [General function prediction only];
430-665 6.75e-09

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 56.07  E-value: 6.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 430 GTTPHPLVVCPHG-GPHAvfdARWRPSMAALCWLGFAVLLVNYRGSLGFGQAS---IECLQSRVGEQDVADTQLAVEQAL 505
Cdd:COG0400     1 GGPAAPLVVLLHGyGGDE---EDLLPLAPELALPGAAVLAPRAPVPEGPGGRAwfdLSFLEGREDEEGLAAAAEALAAFI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 506 RYE----SLDPHRVALLAGSHGAFIALHLLTRQPERYQACALrnpvsnlpalLGTsdipdwrytslglpysfqRVPRVED 581
Cdd:COG0400    78 DELearyGIDPERIVLAGFSQGAAMALSLALRRPELLAGVVA----------LSG------------------YLPGEEA 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 582 LvvmlqrsPIIQAPRVRAPVLLCVGARDRRVSPTQALELYRVLRAHRVPTRLLWYPeGGHALTGVEMEAdvfgnCARWFL 661
Cdd:COG0400   130 L-------PAPEAALAGTPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREYP-GGHEISPEELAD-----ARAWLA 196


                  ....
gi 2024454292 662 QHLG 665
Cdd:COG0400   197 ERLA 200
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 435-578 3.87e-08

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 54.82  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 435 PLVVCPHGGPHAVfdARWRPSMAALCWLGFAVLLVNYRGslgFGQASIECLQSRVGEQDVADtqlAVEQALryESLDPHR 514
Cdd:pfam00561   1 PPVLLLHGLPGSS--DLWRKLAPALARDGFRVIALDLRG---FGKSSRPKAQDDYRTDDLAE---DLEYIL--EALGLEK 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024454292 515 VALLAGSHGAFIALHLLTRQPERYQACALRNPVSNLPALlgtsdIPDWRYTSLGLPYSFQRVPR 578
Cdd:pfam00561  71 VNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDPPHEL-----DEADRFILALFPGFFDGFVA 129
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
500-644 4.97e-05

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 45.32  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 500 AVEQALRYESLDPHRVALLAGSHGAFIALHLLTRQPERYQACAL------RNPVSNLPALL---------GTSDIPDWRY 564
Cdd:COG1647    71 DVEEAYEILKAGYDKVIVIGLSMGGLLALLLAARYPDVAGLVLLspalkiDDPSAPLLPLLkylarslrgIGSDIEDPEV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 565 TSLGlpYSFQRVPRVEDLVVMLQRSPIiQAPRVRAPVLLCVGARDRRVSPTQALELYRVLRAHRVptRLLWYPEGGHALT 644
Cdd:COG1647   151 AEYA--YDRTPLRALAELQRLIREVRR-DLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDK--ELVWLEDSGHVIT 225
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
 418-664 7.96e-05

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 45.18  E-value: 7.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 418 QPFEALLLSPTGGTtPHPLVVCPHG---GPHAVFDARWRPSMaalcwlGFAVLLVNYRG---SLGFGQASIECLQSRV-- 489
Cdd:COG3458    67 ARIYGWLLRPKGEG-PLPAVVEFHGyggGRGLPHEDLDWAAA------GYAVLVMDTRGqgsSWGDTPDPGGYSGGALpg 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 490 ----GEQD---------VADTQLAVEQALRYESLDPHRVALLAGSHGAFIALhlltrqperyQACALRNPV----SNLPA 552
Cdd:COG3458   140 ymtrGIDDpdtyyyrrvYLDAVRAVDALRSLPEVDGKRIGVTGGSQGGGLAL----------AAAALDPRVkaaaADVPF 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 553 LlgtSDIPdwRYTSLGL--PY---------SFQRVPRVE------DLVVMlqrspiiqAPRVRAPVLLCVGARDRRVSPT 615
Cdd:COG3458   210 L---CDFR--RALELGRagPYpeirrylrrHREREPEVFetlsyfDAVNF--------ARRIKAPVLFSVGLMDPVCPPS 276

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2024454292 616 QALELYRVLRAhrvPTRLLWYPEGGHALTGVEMEADVFgncaRWFLQHL 664
Cdd:COG3458   277 TVFAAYNALAG---PKEILVYPFNGHEGGGPEQQDRQL----AFLRELL 318
AXE1 pfam05448
Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase ...
 418-653 6.49e-04

Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.


Pssm-ID: 398876 [Multi-domain]  Cd Length: 316  Bit Score: 42.39  E-value: 6.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 418 QPFEALLLSPTGGTTPHPLVVCPHGgphavFDAR-WRPSmAALCW--LGFAVLLVNYRGSLGFGQasiECLQSRVGEQ-- 492
Cdd:pfam05448  66 ARIYAWYVVPKESEEKHPAVVHFHG-----YNGRrGDWH-DMLHWaaHGYAVFVMDVRGQGGLSE---DDPRGPKGNTyk 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 493 ----------------DV-ADTQLAVEQALRYESLDPHRVALLAGSHGAFIALhlltrqperyqACALRNP-----VSNL 550
Cdd:pfam05448 137 ghitrglldretyyyrRVfLDAVRAVEIVMSFPEVDEERIVVTGGSQGGALAL-----------AAAALSPrikavVADY 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 551 PALlgtSDIPdwRYTSLGL--PYS-----FQRVP---RVEDLVVMLQRSPIIQ-APRVRAPVLLCVGARDRRVSPTQALE 619
Cdd:pfam05448 206 PFL---SDFR--RAWEMDLehPYDelnryFKRDPhheREEEAFRTLSYFDIKNlAHRVKGPVLMAIGLIDDVCPPSTVFA 280

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2024454292 620 LYRVLRAhrvPTRLLWYPEGGHALTGVEMEADVF 653
Cdd:pfam05448 281 AYNHLTT---EKEIRVYPYFAHEYLGAFQNDKIY 311
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 268-350 1.89e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 268 CSNR--RSGIFHLELASGHCELLSAPNRASFSPRLSPDGQHLLYLEGAVGGPHrqclqlrldLLLVDTETATVTNLTAGS 345
Cdd:COG0823    48 TSDRggGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSRSDGRFD---------IYVLDLDGGAPRRLTDGP 118


                  ....*
gi 2024454292 346 PEGCW 350
Cdd:COG0823   119 GSPSW 123
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
433-649 1.97e-03

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 40.15  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 433 PHPLvvcpHGGP---HAVFDArwrpsMAALCWLGFAVLLVNYRG---SLG-FGQAsieclqsrVGEQDvaDTQLAVEQAL 505
Cdd:COG2945    31 PHPL----FGGTmdnKVVYTL-----ARALVAAGFAVLRFNFRGvgrSEGeFDEG--------RGELD--DAAAALDWLR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024454292 506 RYESLDPHrvalLAG-SHGAFIALHLLTRQPEryqacalrnpVSNLpallgtsdipdwryTSLGLPYSFQRVPRVEdlvv 584
Cdd:COG2945    92 AQNPLPLW----LAGfSFGAYVALQLAMRLPE----------VEGL--------------ILVAPPVNRYDFSFLA---- 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024454292 585 mlqrspiiqapRVRAPVLLCVGARDRRVSPTQALELyrvLRAHRVPTRLLWYPEGGHALTGVEME 649
Cdd:COG2945   140 -----------PCPAPTLVIHGEQDEVVPPAEVLDW---ARPLSPPLPVVVVPGADHFFHGKLDE 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH