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Conserved domains on  [gi|2024462921|ref|XP_040541727|]
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protein Niban 2 isoform X2 [Gallus gallus]

Protein Classification

PH domain-containing protein( domain architecture ID 10643714)

Pleckstrin homology (PH) domain-containing protein may be involved in targeting a protein to the appropriate cellular location or interacting with a binding partner

CATH:  2.30.29.30
Gene Ontology:  GO:0005515
PubMed:  22728242|17233582|15493994

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Niban-like cd23949
Niban-like protein; Niban-like proteins contain an N-terminal Pleckstrin-Homology (PH) domain ...
 9-554 0e+00

Niban-like protein; Niban-like proteins contain an N-terminal Pleckstrin-Homology (PH) domain that may be involved in binding to specific ligands. Phosphatidylinositol (3)-phosphate (PI3P) was recognized as the innate ligand of the PH domain of MINERVA (melanoma invasion by ERK, also known as FAM129B) PH. Niban family proteins have been found to regulate phosphorylation of a number of proteins involved in the regularion of translation, such as EIF2A, EIF4EBP1 and RPS6KB1. They may also be involved in the endoplasmic reticulum stress response (FAM129A, Niban-like protein 1), suggested to play a role in apoptosis suppression in cancer cells, while Niban-like protein 2 (FAM129C) is a B-cell membrane protein that is overexpressed in chronic lymphocytic leukemia.


:

Pssm-ID: 469558 [Multi-domain]  Cd Length: 550  Bit Score: 816.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921   9 RRKGQKLEKTGKVLGEFSRCYREQYGVALFNSIRYEIEGNGGPQAQLLHRKVPLED-HVIYSGNLFQYIEENKKWRNRFC 87
Cdd:cd23949     4 AERNYIREKTGAFLKEFGPEYEKQYAVALLNSVRKELEQQEGPQWQLLKRKPPPEDrKVIFSGKLSKYGEDSKKWKERFC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  88 VVPHNYGLVLYENKLAYERELPPRVLINSAGYKVLTSVEQYLELVSSSLPGITPKSGNT--PILKCPTDFPLILWHPYAR 165
Cdd:cd23949    84 VVRGDYNLEYYESKEAYERGKKPKGSINLAGYKVLTSPEEYLELVDRKFPDLAGKSEKAsvPFPERPPPFTLELYHPYRR 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 166 HYYFCLMTGKEQEKWGAVFQDCVRHCNNGISEDSKVEAPAFTDAVRMYRQSKEQYGTWDMLCGNQSQVLSNLVMEELLPE 245
Cdd:cd23949   164 HYYFCFETEKEQEEWVAVLQDCIRHVNWVLPKDTTVEARAFLEAVRLYRQEKGHYGTWDMLSGNEAQILSDLVMEELLPD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 246 LRSAIGPRLKGKTQERQRTWIQISDAVYRMVYEQTKAQYDAMVAKCELERPQMESSIRTDMDQIITSKEHLASKIRAFVL 325
Cdd:cd23949   244 LLTELLPKLKGKGQERKRAWNKILEAVYTLVSEQVSEAWTALKQECEELRPELEAKIRSDMDQIIASKEHLAGKIRAMVS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 326 PKAEICVRNHVQPYISSILEALMTPTSQGFAEVREVFFKEVTDMNMNIVNEGGLEKLVEYMEKLSHLAFHPVKMQSCYEK 405
Cdd:cd23949   324 PPAKSFLAEHVQPHLPSILEELMGPVSAGFVEVRRLFEKEVERLSENLENSGDDDKLREYLESLGNLPDAPVKMQPCYEK 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 406 MEQLKLEGLQQRFDVSSTSVFKQRAQIHMRQQMDDALYTFETLLHQELGklQGKDELCKSIQRILERVLKKYDYDSSTVR 485
Cdd:cd23949   404 VERLKLELQQQRFDFLSPRVLVQRAQILMRELMDNAVYTFEQLLEDALT--SDPSQLAKTIEKVLDRVLKKFDYDSSTVR 481

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024462921 486 KKFFREALLQITIPFLLKKLAPTCKGELAKFQELIFEDFASFILVENTYEEVVLQSVMKDIMQAVKEAA 554
Cdd:cd23949   482 KRFFREALLQITLPFFLKALAPACKPELPKFESLIFADYSEFILVENIYEEVLLQILLDDIVKVVKEAA 550
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
772-890 6.53e-06

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14951:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 618  Bit Score: 49.71  E-value: 6.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 772 AAPASSVSGAEVTSGAEIPSGDKVPHGTSASPAPGADVPPSDKVHRGVPASPAPRAEIPPGDEVHRA-TPASPAPRAEVP 850
Cdd:PRK14951  375 PAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAApAAVALAPAPPAQ 454

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2024462921 851 LPPAGTTCHQRSDKETGEEVALPEACSPPQPAGTTESIEG 890
Cdd:PRK14951  455 AAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 645-883 2.05e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 645 GSPDGVAEIREVLAKEsievlteerlTNGTHstqdsgatKEVVVAAGAAPGDGPNKGPAGDGGGARRAAPAAPTSGAKVP 724
Cdd:PRK07764  562 ASPGNAEVLVTALAEE----------LGGDW--------QVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAA 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 725 SEdgvrrapaappAPEAESAARDEVQRAVPASPTTGTEVLSQDGLHRAAPASSVSGAEVTSGAEIPSGDkVPHGTSASPA 804
Cdd:PRK07764  624 PA-----------APAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP-PPAPAPAAPA 691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 805 PGADVPPSDKVHRGVPASPAPRAEIPPGDEVHRATPASPAPRAE---VPLPPAgttchqrSDKETGEEVALPEACSPPQP 881
Cdd:PRK07764  692 APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAAddpVPLPPE-------PDDPPDPAGAPAQPPPPPAP 764


                  ..
gi 2024462921 882 AG 883
Cdd:PRK07764  765 AP 766
 
Name Accession Description Interval E-value
Niban-like cd23949
Niban-like protein; Niban-like proteins contain an N-terminal Pleckstrin-Homology (PH) domain ...
 9-554 0e+00

Niban-like protein; Niban-like proteins contain an N-terminal Pleckstrin-Homology (PH) domain that may be involved in binding to specific ligands. Phosphatidylinositol (3)-phosphate (PI3P) was recognized as the innate ligand of the PH domain of MINERVA (melanoma invasion by ERK, also known as FAM129B) PH. Niban family proteins have been found to regulate phosphorylation of a number of proteins involved in the regularion of translation, such as EIF2A, EIF4EBP1 and RPS6KB1. They may also be involved in the endoplasmic reticulum stress response (FAM129A, Niban-like protein 1), suggested to play a role in apoptosis suppression in cancer cells, while Niban-like protein 2 (FAM129C) is a B-cell membrane protein that is overexpressed in chronic lymphocytic leukemia.


Pssm-ID: 469558 [Multi-domain]  Cd Length: 550  Bit Score: 816.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921   9 RRKGQKLEKTGKVLGEFSRCYREQYGVALFNSIRYEIEGNGGPQAQLLHRKVPLED-HVIYSGNLFQYIEENKKWRNRFC 87
Cdd:cd23949     4 AERNYIREKTGAFLKEFGPEYEKQYAVALLNSVRKELEQQEGPQWQLLKRKPPPEDrKVIFSGKLSKYGEDSKKWKERFC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  88 VVPHNYGLVLYENKLAYERELPPRVLINSAGYKVLTSVEQYLELVSSSLPGITPKSGNT--PILKCPTDFPLILWHPYAR 165
Cdd:cd23949    84 VVRGDYNLEYYESKEAYERGKKPKGSINLAGYKVLTSPEEYLELVDRKFPDLAGKSEKAsvPFPERPPPFTLELYHPYRR 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 166 HYYFCLMTGKEQEKWGAVFQDCVRHCNNGISEDSKVEAPAFTDAVRMYRQSKEQYGTWDMLCGNQSQVLSNLVMEELLPE 245
Cdd:cd23949   164 HYYFCFETEKEQEEWVAVLQDCIRHVNWVLPKDTTVEARAFLEAVRLYRQEKGHYGTWDMLSGNEAQILSDLVMEELLPD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 246 LRSAIGPRLKGKTQERQRTWIQISDAVYRMVYEQTKAQYDAMVAKCELERPQMESSIRTDMDQIITSKEHLASKIRAFVL 325
Cdd:cd23949   244 LLTELLPKLKGKGQERKRAWNKILEAVYTLVSEQVSEAWTALKQECEELRPELEAKIRSDMDQIIASKEHLAGKIRAMVS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 326 PKAEICVRNHVQPYISSILEALMTPTSQGFAEVREVFFKEVTDMNMNIVNEGGLEKLVEYMEKLSHLAFHPVKMQSCYEK 405
Cdd:cd23949   324 PPAKSFLAEHVQPHLPSILEELMGPVSAGFVEVRRLFEKEVERLSENLENSGDDDKLREYLESLGNLPDAPVKMQPCYEK 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 406 MEQLKLEGLQQRFDVSSTSVFKQRAQIHMRQQMDDALYTFETLLHQELGklQGKDELCKSIQRILERVLKKYDYDSSTVR 485
Cdd:cd23949   404 VERLKLELQQQRFDFLSPRVLVQRAQILMRELMDNAVYTFEQLLEDALT--SDPSQLAKTIEKVLDRVLKKFDYDSSTVR 481

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024462921 486 KKFFREALLQITIPFLLKKLAPTCKGELAKFQELIFEDFASFILVENTYEEVVLQSVMKDIMQAVKEAA 554
Cdd:cd23949   482 KRFFREALLQITLPFFLKALAPACKPELPKFESLIFADYSEFILVENIYEEVLLQILLDDIVKVVKEAA 550
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 772-890 6.53e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 49.71  E-value: 6.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 772 AAPASSVSGAEVTSGAEIPSGDKVPHGTSASPAPGADVPPSDKVHRGVPASPAPRAEIPPGDEVHRA-TPASPAPRAEVP 850
Cdd:PRK14951  375 PAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAApAAVALAPAPPAQ 454

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2024462921 851 LPPAGTTCHQRSDKETGEEVALPEACSPPQPAGTTESIEG 890
Cdd:PRK14951  455 AAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 754-889 3.41e-05

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 46.67  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 754 PASPTT-----GTEVLSQDGLHRAAPAS-SVSGAEVTSGAEIPSgdkvphgtsASPAPGADVPPSDKVhrgvPASPAPRA 827
Cdd:pfam16072 146 PGSVTTtsagsGTTVINAGGQQPAAPAApAYPVAPAAYPAQAPA---------AAPAPAPGAPQTPLA----PLNPVAAA 212

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024462921 828 EIPPGDEVHRATPASPAPRAEVPLPPA-GTTCHQRSDKETGEEVALPEACSPPQPAGTTESIE 889
Cdd:pfam16072 213 PAAAAGAAAAPVVAAAAPAAAAPPPPApAAPPADAAPPAPGGIICVPVRVPEPDPKDATKTIE 275
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 645-883 2.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 645 GSPDGVAEIREVLAKEsievlteerlTNGTHstqdsgatKEVVVAAGAAPGDGPNKGPAGDGGGARRAAPAAPTSGAKVP 724
Cdd:PRK07764  562 ASPGNAEVLVTALAEE----------LGGDW--------QVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAA 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 725 SEdgvrrapaappAPEAESAARDEVQRAVPASPTTGTEVLSQDGLHRAAPASSVSGAEVTSGAEIPSGDkVPHGTSASPA 804
Cdd:PRK07764  624 PA-----------APAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP-PPAPAPAAPA 691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 805 PGADVPPSDKVHRGVPASPAPRAEIPPGDEVHRATPASPAPRAE---VPLPPAgttchqrSDKETGEEVALPEACSPPQP 881
Cdd:PRK07764  692 APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAAddpVPLPPE-------PDDPPDPAGAPAQPPPPPAP 764


                  ..
gi 2024462921 882 AG 883
Cdd:PRK07764  765 AP 766
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 66-189 2.70e-03

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 38.30  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921   66 VIYSGNLFQYIEE-NKKWRNRFCVVPHNYgLVLYENKLAYERELPPRVLinsagykvltsveqylelvssSLPGITPKSg 144
Cdd:smart00233   1 VIKEGWLYKKSGGgKKSWKKRYFVLFNST-LLYYKSKKDKKSYKPKGSI---------------------DLSGCTVRE- 57

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2024462921  145 NTPILKCPTDFPLILWHPYARHYYFCLMTGKEQEKWGAVFQDCVR 189
Cdd:smart00233  58 APDPDSSKKPHCFEIKTSDRKTLLLQAESEEEREKWVEALRKAIA 102
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 66-189 4.25e-03

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 37.54  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  66 VIYSGNLFQYIEENKK-WRNRFCVVpHNYGLVLYENKLAYERELPPRVlINSAGYKVLTSVEQYlelvssslpgitpksg 144
Cdd:pfam00169   1 VVKEGWLLKKGGGKKKsWKKRYFVL-FDGSLLYYKDDKSGKSKEPKGS-ISLSGCEVVEVVASD---------------- 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2024462921 145 ntpilKCPTDFPLILWHPYARH---YYFCLMTGKEQEKWGAVFQDCVR 189
Cdd:pfam00169  63 -----SPKRKFCFELRTGERTGkrtYLLQAESEEERKDWIKAIQSAIR 105
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 746-854 6.75e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 38.52  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 746 RDEVQRAVPASPTTGT--EVLSQDGLHRAAPASSVSGAEVTSGAEIPSGDKVPhgTSASPAPGADVPPSDKVHRGVPASP 823
Cdd:cd21975    50 GPAWKPDGADSPGLVTaaPHLLAANVLAPLRGPSVEGSSLESGDADMGSDSDV--APASGAAASTSPESSSDAASSPSPL 127

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024462921 824 APRAEIPPGDEVHRATPASPAPRAEVPLPPA 854
Cdd:cd21975   128 SLLHPGEAGLEPERPRPRVRRGVRRRGVTPA 158
 
Name Accession Description Interval E-value
Niban-like cd23949
Niban-like protein; Niban-like proteins contain an N-terminal Pleckstrin-Homology (PH) domain ...
 9-554 0e+00

Niban-like protein; Niban-like proteins contain an N-terminal Pleckstrin-Homology (PH) domain that may be involved in binding to specific ligands. Phosphatidylinositol (3)-phosphate (PI3P) was recognized as the innate ligand of the PH domain of MINERVA (melanoma invasion by ERK, also known as FAM129B) PH. Niban family proteins have been found to regulate phosphorylation of a number of proteins involved in the regularion of translation, such as EIF2A, EIF4EBP1 and RPS6KB1. They may also be involved in the endoplasmic reticulum stress response (FAM129A, Niban-like protein 1), suggested to play a role in apoptosis suppression in cancer cells, while Niban-like protein 2 (FAM129C) is a B-cell membrane protein that is overexpressed in chronic lymphocytic leukemia.


Pssm-ID: 469558 [Multi-domain]  Cd Length: 550  Bit Score: 816.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921   9 RRKGQKLEKTGKVLGEFSRCYREQYGVALFNSIRYEIEGNGGPQAQLLHRKVPLED-HVIYSGNLFQYIEENKKWRNRFC 87
Cdd:cd23949     4 AERNYIREKTGAFLKEFGPEYEKQYAVALLNSVRKELEQQEGPQWQLLKRKPPPEDrKVIFSGKLSKYGEDSKKWKERFC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  88 VVPHNYGLVLYENKLAYERELPPRVLINSAGYKVLTSVEQYLELVSSSLPGITPKSGNT--PILKCPTDFPLILWHPYAR 165
Cdd:cd23949    84 VVRGDYNLEYYESKEAYERGKKPKGSINLAGYKVLTSPEEYLELVDRKFPDLAGKSEKAsvPFPERPPPFTLELYHPYRR 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 166 HYYFCLMTGKEQEKWGAVFQDCVRHCNNGISEDSKVEAPAFTDAVRMYRQSKEQYGTWDMLCGNQSQVLSNLVMEELLPE 245
Cdd:cd23949   164 HYYFCFETEKEQEEWVAVLQDCIRHVNWVLPKDTTVEARAFLEAVRLYRQEKGHYGTWDMLSGNEAQILSDLVMEELLPD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 246 LRSAIGPRLKGKTQERQRTWIQISDAVYRMVYEQTKAQYDAMVAKCELERPQMESSIRTDMDQIITSKEHLASKIRAFVL 325
Cdd:cd23949   244 LLTELLPKLKGKGQERKRAWNKILEAVYTLVSEQVSEAWTALKQECEELRPELEAKIRSDMDQIIASKEHLAGKIRAMVS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 326 PKAEICVRNHVQPYISSILEALMTPTSQGFAEVREVFFKEVTDMNMNIVNEGGLEKLVEYMEKLSHLAFHPVKMQSCYEK 405
Cdd:cd23949   324 PPAKSFLAEHVQPHLPSILEELMGPVSAGFVEVRRLFEKEVERLSENLENSGDDDKLREYLESLGNLPDAPVKMQPCYEK 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 406 MEQLKLEGLQQRFDVSSTSVFKQRAQIHMRQQMDDALYTFETLLHQELGklQGKDELCKSIQRILERVLKKYDYDSSTVR 485
Cdd:cd23949   404 VERLKLELQQQRFDFLSPRVLVQRAQILMRELMDNAVYTFEQLLEDALT--SDPSQLAKTIEKVLDRVLKKFDYDSSTVR 481

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024462921 486 KKFFREALLQITIPFLLKKLAPTCKGELAKFQELIFEDFASFILVENTYEEVVLQSVMKDIMQAVKEAA 554
Cdd:cd23949   482 KRFFREALLQITLPFFLKALAPACKPELPKFESLIFADYSEFILVENIYEEVLLQILLDDIVKVVKEAA 550
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 772-890 6.53e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 49.71  E-value: 6.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 772 AAPASSVSGAEVTSGAEIPSGDKVPHGTSASPAPGADVPPSDKVHRGVPASPAPRAEIPPGDEVHRA-TPASPAPRAEVP 850
Cdd:PRK14951  375 PAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAApAAVALAPAPPAQ 454

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2024462921 851 LPPAGTTCHQRSDKETGEEVALPEACSPPQPAGTTESIEG 890
Cdd:PRK14951  455 AAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
685-887 2.51e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 685 EVVVAAGAAPGDGPNKGPAGdgggarraapAAPTSGAKVPSEDGVRrAPAAPPAPEAESAARDEVQRAVPASPTTGTEVL 764
Cdd:PRK07003  359 EPAVTGGGAPGGGVPARVAG----------AVPAPGARAAAAVGAS-AVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 765 SQDGlhrAAPASSVSGAEVTSGAEIPSGDKVPHGTSASPAPGADVPPSDKVHRGVPASPAP----RAEIPPGDEVHRATp 840
Cdd:PRK07003  428 AAPA---PPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPpdaaFEPAPRAAAPSAAT- 503

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2024462921 841 aspAPRAEVPLPPAGTtchQRSDKETGEEVALPEAcSPPQPAGTTES 887
Cdd:PRK07003  504 ---PAAVPDARAPAAA---SREDAPAAAAPPAPEA-RPPTPAAAAPA 543
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
680-881 3.19e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.92  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 680 SGATKEVVVAAGAAPGDGPNKGPAgdGGGARRAAPAAPTSGAKVPSEDGVRRAPAAPPAPEAESAARDEVQRAVPAS--- 756
Cdd:PRK07003  408 AALAPKAAAAAAATRAEAPPAAPA--PPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASdap 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 757 PTTGTEVLSQDGLHRAAPASSVSGAEVTSGA---EIPSGDKVPHGTSASPAPGADVPPSD----------------KVH- 816
Cdd:PRK07003  486 PDAAFEPAPRAAAPSAATPAAVPDARAPAAAsreDAPAAAAPPAPEARPPTPAAAAPAARaggaaaaldvlrnagmRVSs 565

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024462921 817 -RGVPASPAPRAEIPPGdevhrATPASPAPRAEVPLPPAGTTCHQRSDKETGEEVALPEACSPPQP 881
Cdd:PRK07003  566 dRGARAAAAAKPAAAPA-----AAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAP 626
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 754-889 3.41e-05

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 46.67  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 754 PASPTT-----GTEVLSQDGLHRAAPAS-SVSGAEVTSGAEIPSgdkvphgtsASPAPGADVPPSDKVhrgvPASPAPRA 827
Cdd:pfam16072 146 PGSVTTtsagsGTTVINAGGQQPAAPAApAYPVAPAAYPAQAPA---------AAPAPAPGAPQTPLA----PLNPVAAA 212

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024462921 828 EIPPGDEVHRATPASPAPRAEVPLPPA-GTTCHQRSDKETGEEVALPEACSPPQPAGTTESIE 889
Cdd:pfam16072 213 PAAAAGAAAAPVVAAAAPAAAAPPPPApAAPPADAAPPAPGGIICVPVRVPEPDPKDATKTIE 275
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 748-893 1.10e-04

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 45.85  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 748 EVQRAVPASPTT------GTEVLSQDGLHRAAPASSVSGAEVTSGAEIP-----------SGDKVPHGTSASP-APGADV 809
Cdd:PLN02217  508 EVQNTGPGAAITkrvtwpGIKKLSDEEILKFTPAQYIQGDAWIPGKGVPyipglfagnpgSTNSTPTGSAASSnTTFSSD 587

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 810 PPSDKVhrgVPAS--PAPRAEIPPGDEVHRATPASPAPRAEVPLPPAGTTCHQRSDKETGEEVALPEACSPPQPAGTTES 887
Cdd:PLN02217  588 SPSTVV---APSTspPAGHLGSPPATPSKIVSPSTSPPASHLGSPSTTPSSPESSIKVASTETASPESSIKVASTESSVS 664


                  ....*.
gi 2024462921 888 IEGMQT 893
Cdd:PLN02217  665 MVSMST 670
PHA03247 PHA03247
large tegument protein UL36; Provisional
 675-879 3.34e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  675 HSTQDSGATKEVVVAAGAAPGDGP--NKGPAGDGGGARRAAPAAPTSGAKVPSEDGVRRAPAAPPAPEAESAARDEVQR- 751
Cdd:PHA03247  2807 PPAAVLAPAAALPPAASPAGPLPPptSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRl 2886

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  752 AVPA-SPTTGTEVLSQDGLHRAAPASSVSGAEVTSGAEIPSGDKVPHGTSASP-APGADVPPSDKVHRGVPASPAPR--A 827
Cdd:PHA03247  2887 ARPAvSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPqPPLAPTTDPAGAGEPSGAVPQPWlgA 2966

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024462921  828 EIPPGDEVHRATPASPAPRAEVPLPPAGTTCHQRSDKET--GEEVALPEACSPP 879
Cdd:PHA03247  2967 LVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSswASSLALHEETDPP 3020
PHA03381 PHA03381
tegument protein VP22; Provisional
 772-884 6.83e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 42.69  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 772 AAPASSVSGAEV------TSGAEIPsgdkVPHGTSASPAPGADVPPSDKVHR--GVPASPAPRAEIPPGDEVHRATPA-S 842
Cdd:PHA03381   48 AGQARGRSQAERrfhhydEARADYP----YYTGSSSEDERPADPRPSRRPHAqpEASGPGPARGARGPAGSRGRGRRAeS 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2024462921 843 PAPRAevPLPPAGTTCHQRSDKETGEEVALPEACSPPQPAGT 884
Cdd:PHA03381  124 PSPRD--PPNPKGASAPRGRKSACADSAALLDAPAPAAPKRQ 163
PHA03378 PHA03378
EBNA-3B; Provisional
 753-883 1.08e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 753 VPASPTTGTEVLSQdgLHRAAPASSVSGAEVTSGAEIPSGDKVP------HGTSASP---APGADVPPSDKVHRGVPASP 823
Cdd:PHA03378  672 IPYQPSPTGANTML--PIQWAPGTMQPPPRAPTPMRPPAAPPGRaqrpaaATGRARPpaaAPGRARPPAAAPGRARPPAA 749

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024462921 824 APRAEIPPGDEVHRATPASPAPRAEVPLPP--AGTTCHQR---SDKETGEEVALPEA--CSPPQPAG 883
Cdd:PHA03378  750 APGRARPPAAAPGRARPPAAAPGAPTPQPPpqAPPAPQQRprgAPTPQPPPQAGPTSmqLMPRAAPG 816
PHA03247 PHA03247
large tegument protein UL36; Provisional
 689-887 1.08e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  689 AAGAAPGDGPNKGPAGDGGGARRAAPAAPTSGAKVPSEdgvrrAPAAPPAPEAESAARDEVQRAVPASPTTGTEVLSQDG 768
Cdd:PHA03247  2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD-----PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  769 LHRAAPASSVSgaevTSGAEIPSGDKVPHGTSASPAPGADVPPSDKVHR----GVPASPAPRAEIPPGDEVHRATPASPA 844
Cdd:PHA03247  2841 PPPGPPPPSLP----LGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRlarpAVSRSTESFALPPDQPERPPQPQAPPP 2916

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2024462921  845 PRAEVPLPPAGTTCHQRSdketgeevalPEACSPPQPAGTTES 887
Cdd:PHA03247  2917 PQPQPQPPPPPQPQPPPP----------PPPRPQPPLAPTTDP 2949
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 786-882 1.32e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 786 GAEIPSGDKVPHGTSAS---PAPGADVPPSDKVHRGVPASPAPRAEIPPGDEVHRATPASPAPRAevplPPAGTTCHQRS 862
Cdd:pfam03154 421 SQQLPPPPAQPPVLTQSqslPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTST----SSAMPGIQPPS 496

                          90       100
                  ....*....|....*....|
gi 2024462921 863 DKETGEEVALPEACSPPQPA 882
Cdd:pfam03154 497 SASVSSSGPVPAAVSCPLPP 516
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 645-883 2.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 645 GSPDGVAEIREVLAKEsievlteerlTNGTHstqdsgatKEVVVAAGAAPGDGPNKGPAGDGGGARRAAPAAPTSGAKVP 724
Cdd:PRK07764  562 ASPGNAEVLVTALAEE----------LGGDW--------QVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAA 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 725 SEdgvrrapaappAPEAESAARDEVQRAVPASPTTGTEVLSQDGLHRAAPASSVSGAEVTSGAEIPSGDkVPHGTSASPA 804
Cdd:PRK07764  624 PA-----------APAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP-PPAPAPAAPA 691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 805 PGADVPPSDKVHRGVPASPAPRAEIPPGDEVHRATPASPAPRAE---VPLPPAgttchqrSDKETGEEVALPEACSPPQP 881
Cdd:PRK07764  692 APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAAddpVPLPPE-------PDDPPDPAGAPAQPPPPPAP 764


                  ..
gi 2024462921 882 AG 883
Cdd:PRK07764  765 AP 766
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 66-189 2.70e-03

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 38.30  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921   66 VIYSGNLFQYIEE-NKKWRNRFCVVPHNYgLVLYENKLAYERELPPRVLinsagykvltsveqylelvssSLPGITPKSg 144
Cdd:smart00233   1 VIKEGWLYKKSGGgKKSWKKRYFVLFNST-LLYYKSKKDKKSYKPKGSI---------------------DLSGCTVRE- 57

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2024462921  145 NTPILKCPTDFPLILWHPYARHYYFCLMTGKEQEKWGAVFQDCVR 189
Cdd:smart00233  58 APDPDSSKKPHCFEIKTSDRKTLLLQAESEEEREKWVEALRKAIA 102
PHA03247 PHA03247
large tegument protein UL36; Provisional
 774-880 3.93e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 3.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  774 PASSVSGAEVTSGAEIPS-----------GDkvPHGTSASPAPGADVPPSDKVHRGVPASPAPRAEIPPGDEvhrATPAS 842
Cdd:PHA03247  2573 PAPRPSEPAVTSRARRPDappqsarprapVD--DRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHP---PPTVP 2647

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2024462921  843 PAPRAEVPLPPAGTTCHQRSDKETGEevalPEACSPPQ 880
Cdd:PHA03247  2648 PPERPRDDPAPGRVSRPRRARRLGRA----AQASSPPQ 2681
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 66-189 4.25e-03

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 37.54  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  66 VIYSGNLFQYIEENKK-WRNRFCVVpHNYGLVLYENKLAYERELPPRVlINSAGYKVLTSVEQYlelvssslpgitpksg 144
Cdd:pfam00169   1 VVKEGWLLKKGGGKKKsWKKRYFVL-FDGSLLYYKDDKSGKSKEPKGS-ISLSGCEVVEVVASD---------------- 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2024462921 145 ntpilKCPTDFPLILWHPYARH---YYFCLMTGKEQEKWGAVFQDCVR 189
Cdd:pfam00169  63 -----SPKRKFCFELRTGERTGkrtYLLQAESEEERKDWIKAIQSAIR 105
PHA03247 PHA03247
large tegument protein UL36; Provisional
 800-882 4.39e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  800 SASPAPGADVPPSDKVHRGVPASPAPRAEIPPGDEVHRATPASPAPR---------AEVPLPPAGTTchQRSDKETGEEV 870
Cdd:PHA03247   369 SAGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRPAAPVPASVptpaptpvpASAPPPPATPL--PSAEPGSDDGP 446

                           90
                   ....*....|..
gi 2024462921  871 ALPEACSPPQPA 882
Cdd:PHA03247   447 APPPERQPPAPA 458
GGN pfam15685
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the ...
 751-871 5.17e-03

Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the maturation of sperm and is expressed virtually only in the testis. It is found to be associated with the intracellular membrane, binds with GGNBP1 and may be involved in vesicular trafficking.


Pssm-ID: 434857 [Multi-domain]  Cd Length: 668  Bit Score: 40.52  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 751 RAVPASPTTGTEVLSQDGLHRAAPASSVSGAEVTSGAEIPSGDKVP-HGTSA-SPAPGADVPPSDKVHRgvpaSPAPRAE 828
Cdd:pfam15685 438 QALLPRPPPPTPPATPPPVPPPIPQLPALQPMPLAAARPPTPRPCPgHGESAlAPAPTAPLPPALAADQ----APAPALA 513

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2024462921 829 IPPgdevhrATPASPAPRAEVPLPPAGTTCHQRSDKETGEEVA 871
Cdd:pfam15685 514 AAP------APSPAPAPATADPLPPAPAPIKARTRKNKGPRAA 550
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 670-859 5.48e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 5.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  670 LTNGTHSTQDSGATKEVVVAAGAAPGDGPNKGPAGDGGGARRAAPAAPTSGAKVPSEDGVRRAPAAPPAPEAESAARDEV 749
Cdd:PHA03307   753 ITDALFSNPSLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSES 832

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  750 QRAVPASPTTGtevlsqDGLH-RAAPASSVSGAEVTSGAEIPSGDKVPHGTSASPAPGADVPPSDKVHRGVPASPAPRAE 828
Cdd:PHA03307   833 SGPARPPGAAA------RPPPaRSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPR 906

                          170       180       190
                   ....*....|....*....|....*....|.
gi 2024462921  829 IPPGDEVHRATPASPAPRAEVPLPPAGtTCH 859
Cdd:PHA03307   907 PAPRVKLGPMPPGGPDPRGGFRRVPPG-DLH 936
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 751-854 6.02e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 6.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921  751 RAVPASPTTGtevlsqDGLHRAAPASSVSGAEVTSGAEIPSGDKVPHGTSASPAPGADVPPSDK--VHRGVPASPAPRAE 828
Cdd:PHA03307   281 RPGPASSSSS------PRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGaaVSPGPSPSRSPSPS 354

                           90       100
                   ....*....|....*....|....*.
gi 2024462921  829 IPPGDEVHRATPASPAPRAEVPLPPA 854
Cdd:PHA03307   355 RPPPPADPSSPRKRPRPSRAPSSPAA 380
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 746-854 6.75e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 38.52  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 746 RDEVQRAVPASPTTGT--EVLSQDGLHRAAPASSVSGAEVTSGAEIPSGDKVPhgTSASPAPGADVPPSDKVHRGVPASP 823
Cdd:cd21975    50 GPAWKPDGADSPGLVTaaPHLLAANVLAPLRGPSVEGSSLESGDADMGSDSDV--APASGAAASTSPESSSDAASSPSPL 127

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024462921 824 APRAEIPPGDEVHRATPASPAPRAEVPLPPA 854
Cdd:cd21975   128 SLLHPGEAGLEPERPRPRVRRGVRRRGVTPA 158
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 747-890 8.13e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 8.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024462921 747 DEVQRAVPASPTTGTEVLSQDGLHRAAPASSVSGAEVTSGAEIPSGDKVPHGTSASPAPGADVPPSDKVHRGVPASPAPR 826
Cdd:PRK07764  379 ERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPP 458

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024462921 827 AEIPPGDEVHRATPASPAPRAEVPLPPAGttchqrsdKETGEEVALPEACSPPQPAGTTESIEG 890
Cdd:PRK07764  459 AAAPSAQPAPAPAAAPEPTAAPAPAPPAA--------PAPAAAPAAPAAPAAPAGADDAATLRE 514
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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