|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
2043-2366 |
5.00e-74 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 246.36 E-value: 5.00e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2043 YNEDQKRAIETAYAMVKqhpglaKICLIHGPPGTGKSKTIVGLLSRVLRENTRNEKTSKK----------NAKIKQNRFL 2112
Cdd:cd18042 1 LNESQLEAIASALQNSP------GITLIQGPPGTGKTKTIVGILSVLLAGKYRKYYEKVKkklrklqrnlNNKKKKNRIL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2113 VCAPSNAAIDELMKKIIIAFKEKCQnrqeplGNCGDIKLVRLGaersinsevrafsldkqvehrmkrkptdrdqdiqkkk 2192
Cdd:cd18042 75 VCAPSNAAVDEIVLRLLSEGFLDGD------GRSYKPNVVRVG------------------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2193 aaldekldmlsrqramhrcekresqmlddeigrlskerqqlasqlkevrghSQKVQTDIILESDIICCTLSTSGGGLLES 2272
Cdd:cd18042 112 ---------------------------------------------------RQELRASILNEADIVCTTLSSSGSDLLES 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2273 afwrqGLDPFSCVIVDEAGQSCEVETLIPLIHRCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARLQRHLEeqvqnnl 2352
Cdd:cd18042 141 -----LPRGFDTVIIDEAAQAVELSTLIPLRLGCKRLILVGDPKQLPATVFSKVAQKLGYDRSLFERLQLAGY------- 208
|
330
....*....|....
gi 2024463408 2353 lrrlPVVQLTVQYR 2366
Cdd:cd18042 209 ----PVLMLTTQYR 218
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
2046-2324 |
4.22e-69 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 233.39 E-value: 4.22e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2046 DQKRAIETAYamvkQHPGlakICLIHGPPGTGKSKTIVGLLSRVLrentrnekTSKKNAKIKQNRFLVCAPSNAAIDELM 2125
Cdd:pfam13086 1 SQREAIRSAL----SSSH---FTLIQGPPGTGKTTTIVELIRQLL--------SYPATSAAAGPRILVCAPSNAAVDNIL 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2126 KKIIiafkekcqnrqePLGNCGDIKLVRLGAERSINSEVRAFSLDKQVEHRMKRKP-TDRDQDIQKKKAALDEKLDMLSR 2204
Cdd:pfam13086 66 ERLL------------RKGQKYGPKIVRIGHPAAISEAVLPVSLDYLVESKLNNEEdAQIVKDISKELEKLAKALRAFEK 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2205 QRAMHRC----EKRESQMLDDEIGrLSKERQQLASQLKEVRghsQKVQTDIILESDIICCTLSTSGGGLLESafwrqgLD 2280
Cdd:pfam13086 134 EIIVEKLlksrNKDKSKLEQERRK-LRSERKELRKELRRRE---QSLEREILDEAQIVCSTLSGAGSRLLSS------LA 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2024463408 2281 PFSCVIVDEAGQSCEVETLIPLIHRCNKLVLVGDPRQLPPTIKS 2324
Cdd:pfam13086 204 NFDVVIIDEAAQALEPSTLIPLLRGPKKVVLVGDPKQLPPTVIS 247
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
2147-2545 |
5.22e-69 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 251.20 E-value: 5.22e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2147 GDIKLVRLGAERSINSEVRAFSLDKQVEHRMKRKPTDRDQDIQKKKAALDEKLDMLSRQRAMHRCEKRESQMLDDEIGRL 2226
Cdd:COG1112 427 LLLALALLAALLALLLLLAAALAALLALLLLLLLALAALLLLLAAAAALLALALLESLLEELIEEHPEELEKLIAELREA 506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2227 SKERQQLASQLKEVRGHSQKVQTDIILESDIICCTLSTSggglleSAFWRQGLDPFSCVIVDEAGQSCEVETLIPLIhRC 2306
Cdd:COG1112 507 ARLRRALRRELKKRRELRKLLWDALLELAPVVGMTPASV------ARLLPLGEGSFDLVIIDEASQATLAEALGALA-RA 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2307 NKLVLVGDPRQLPPTIKSIKAQ---EYGYGQSLMARLQRHLEEqvqnnllrrlPVVQLTVQYRMHPDICLFPSSYIYDKT 2383
Cdd:COG1112 580 KRVVLVGDPKQLPPVVFGEEAEevaEEGLDESLLDRLLARLPE----------RGVMLREHYRMHPEIIAFSNRLFYDGK 649
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2384 LKTDKATEENRCssEWPFQPYLVFDVgDGHEERDKDSFSNPQEVKLVLEIIRTIKEKRKDlgLRRIGIITPYSAQKKKIQ 2463
Cdd:COG1112 650 LVPLPSPKARRL--ADPDSPLVFIDV-DGVYERRGGSRTNPEEAEAVVELVRELLEDGPD--GESIGVITPYRAQVALIR 724
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2464 EELDRVFKNNSPG-EVDTVDAFQGREKDCIIVTCVRANSSK--GSIGFLAS-LQRLNVTITRARFSLFILGRLKTLMEQK 2539
Cdd:COG1112 725 ELLREALGDGLEPvFVGTVDRFQGDERDVIIFSLVYSNDEDvpRNFGFLNGgPRRLNVAVSRARRKLIVVGSRELLDSDP 804
|
....*.
gi 2024463408 2540 SFHLYK 2545
Cdd:COG1112 805 STPALK 810
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
2332-2530 |
8.48e-69 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 230.51 E-value: 8.48e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2332 YGQSLMARLQRHLEEqvqnnllrrlPVVQLTVQYRMHPDICLFPSSYIYDKTLKTDKATEENRCSSEW----PFQPYLVF 2407
Cdd:pfam13087 1 LDRSLFERLQELGPS----------AVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPLPDDFhlpdPLGPLVFI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2408 DVGDGHEERDK--DSFSNPQEVKLVLEIIRTIKEKRKDLGlRRIGIITPYSAQKKKIQEELDRVFKNNSPGEVDTVDAFQ 2485
Cdd:pfam13087 71 DVDGSEEEESDggTSYSNEAEAELVVQLVEKLIKSGPEEP-SDIGVITPYRAQVRLIRKLLKRKLGGKLEIEVNTVDGFQ 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2024463408 2486 GREKDCIIVTCVRANsSKGSIGFLASLQRLNVTITRARFSLFILG 2530
Cdd:pfam13087 150 GREKDVIIFSCVRSN-EKGGIGFLSDPRRLNVALTRAKRGLIIVG 193
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
1952-2541 |
2.78e-65 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 235.48 E-value: 2.78e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 1952 SRASGCLTRQKDQHTVCHLSVQTrgnlSFFVNNEVKCMVVGSLVPTQRSFKGLLLLSR--SPLAKPIINPSYsdfcPRDl 2029
Cdd:TIGR00376 74 SDLTGVVTRVGKRFITVALEESV----PQWSLKRVRIDLYANDVTFKRMKEALRALTEnhSRLLEFLLGREA----PSK- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2030 PVSSESATFCMNEYNEDQKRAIETAYamvkqhpGLAKICLIHGPPGTGKSKTIVGLLSRVLrentrnektsKKNAKIkqn 2109
Cdd:TIGR00376 145 ASEIHDFQFFDPNLNESQKEAVLFAL-------SSKDLFLIHGPPGTGKTRTVVELIRQLV----------KRGLRV--- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2110 rfLVCAPSNAAIDELMKKIIIAfkekcqnrqeplgncgDIKLVRLGAERSINSEVRAFSLDKQVEHRMKRKptdRDQDIQ 2189
Cdd:TIGR00376 205 --LVTAPSNIAVDNLLERLALC----------------DQKIVRLGHPARLLKSNKQHSLDYLIENHPKYQ---IVADIR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2190 KKKAALDEKLDML---SRQRAMHRCE---------KRESQMLDDEI----GRLSKERQQLASQLKEVRGHSQKVQTDIIL 2253
Cdd:TIGR00376 264 EKIDELIEERNKKtkpSPQKRRGLSDikilrkalkKREARGIESLKiasmAEWIETNKSIDRLLKLLPESEERIMNEILA 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2254 ESDIiccTLSTSGGGLLEsaFWRqgldpFSCVIVDEAGQSCEVETLIPLIhRCNKLVLVGDPRQLPPTIKSIKAQEygYG 2333
Cdd:TIGR00376 344 ESDA---TNSMAGSEILN--GQY-----FDVAVIDEASQAMEPSCLIPLL-KARKLILAGDHKQLPPTILSHDAEE--LS 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2334 QSLMARLQRHLEEQVQnnllrrlpvvQLTVQYRMHPDICLFPSSYIYDKTLKTDK-------------ATEENRCSSEWP 2400
Cdd:TIGR00376 411 LTLFERLIKEYPERSR----------TLNVQYRMNQKIMEFPSREFYNGKLTAHEsvanillrdlpkvEATESEDDLETG 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2401 fQPYLVFDV-GDGHEE-RDKDSFS--NPQEVKLVLEIIRTIkeKRKDLGLRRIGIITPYSAQ----KKKIQEELDRVfkn 2472
Cdd:TIGR00376 481 -IPLLFIDTsGCELFElKEADSTSkyNPGEAELVSEIIQAL--VKMGVPANDIGVITPYDAQvdllRQLLEHRHIDI--- 554
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024463408 2473 nspgEVDTVDAFQGREKDCIIVTCVRANsSKGSIGFLASLQRLNVTITRARFSLFILGRLKTLMEQKSF 2541
Cdd:TIGR00376 555 ----EVSSVDGFQGREKEVIIISFVRSN-RKGEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFY 618
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
2367-2539 |
1.38e-56 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 194.76 E-value: 1.38e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2367 MHPDICLFPSSYIYDKTLK--TDKATEENRCSSEWPFQPYLVFDVGDGHE-ERDKDSFSNPQEVKLVLEIIRTIKEKRkd 2443
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKagVSVAARLNPPPLPGPSKPLVFVDVSGGEErEESGTSKSNEAEAELVVELVKYLLKSG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2444 LGLRRIGIITPYSAQKKKIQEELDRVFKNNSPGEVDTVDAFQGREKDCIIVTCVRANSSKGSIGFLASLQRLNVTITRAR 2523
Cdd:cd18808 79 VKPSSIGVITPYRAQVALIRELLRKRGGLLEDVEVGTVDNFQGREKDVIILSLVRSNESGGSIGFLSDPRRLNVALTRAK 158
|
170
....*....|....*.
gi 2024463408 2524 FSLFILGRLKTLMEQK 2539
Cdd:cd18808 159 RGLIIVGNPDTLSKDP 174
|
|
| SEN1_N |
pfam12726 |
SEN1 N terminal; This domain is found at the N terminal of the helicase SEN1. SEN1 is a Pol II ... |
38-327 |
9.89e-07 |
|
SEN1 N terminal; This domain is found at the N terminal of the helicase SEN1. SEN1 is a Pol II termination factor for noncoding RNA genes. The N terminal of SEN1, unlike the C terminal, is not required for growth.
Pssm-ID: 432746 Cd Length: 744 Bit Score: 54.25 E-value: 9.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 38 LCYCLECVVEYHKAR-------------EKLPSLHQVLLELETSRLVAHIEKSirEEAGEDDELFIVDENGETQLPVYvg 104
Cdd:pfam12726 9 LSSCDKCVRNFHRGKkelrqtfaerfpeETVAQFLDKLDEWDIERILPGLDKA--KEILEKRGIFSKSSLSSHLKEVL-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 105 pdfennlrVPLLEVLKYP-YLLLHEKVSELCVEVLCRMEENHTSFQVFEKYPGIYLFLVHPNEVIRRWAiltARNLGKVD 183
Cdd:pfam12726 85 --------LALYEALCCPpYLRSDPELRALFDYVFKLLQTKKKPLRLGTLLPGMTYFLFDGDPEERRWA---RRQLERLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 184 RDDYydLQEVLTclfkVIELGLFE-SPDIYRSSviekgklillpshlYDNSNYKNYWLGICMLLTVLEEQAMDSLLLGPD 262
Cdd:pfam12726 154 RSLT--PEEFDW----AVHDLLEEaIVHLSNIQ--------------LDPSFIERFWSGFSLILRLLDKDLITHRLRALE 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024463408 263 KQNDFmQSILHTMEKEADDDSTDPFWPALHCFMVILDQLGSKVWGQL--IDPVQAFQTIINSVSYNN 327
Cdd:pfam12726 214 VNPPI-EDIYRLLLNHLSSTLDPPLPDLLRALSLLLEKSGKAFWDAMgpISPQVVLDQIFDNPAFAK 279
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
2042-2120 |
2.67e-03 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 43.04 E-value: 2.67e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024463408 2042 EYNEDQKRAIETAyamVKQHpglaKICLIHGPPGTGKSKTIVGLLsRVLREntrnektskknakiKQNRFLVCAPSNAA 2120
Cdd:COG0507 124 TLSDEQREAVALA---LTTR----RVSVLTGGAGTGKTTTLRALL-AALEA--------------LGLRVALAAPTGKA 180
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
2043-2366 |
5.00e-74 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 246.36 E-value: 5.00e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2043 YNEDQKRAIETAYAMVKqhpglaKICLIHGPPGTGKSKTIVGLLSRVLRENTRNEKTSKK----------NAKIKQNRFL 2112
Cdd:cd18042 1 LNESQLEAIASALQNSP------GITLIQGPPGTGKTKTIVGILSVLLAGKYRKYYEKVKkklrklqrnlNNKKKKNRIL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2113 VCAPSNAAIDELMKKIIIAFKEKCQnrqeplGNCGDIKLVRLGaersinsevrafsldkqvehrmkrkptdrdqdiqkkk 2192
Cdd:cd18042 75 VCAPSNAAVDEIVLRLLSEGFLDGD------GRSYKPNVVRVG------------------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2193 aaldekldmlsrqramhrcekresqmlddeigrlskerqqlasqlkevrghSQKVQTDIILESDIICCTLSTSGGGLLES 2272
Cdd:cd18042 112 ---------------------------------------------------RQELRASILNEADIVCTTLSSSGSDLLES 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2273 afwrqGLDPFSCVIVDEAGQSCEVETLIPLIHRCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARLQRHLEeqvqnnl 2352
Cdd:cd18042 141 -----LPRGFDTVIIDEAAQAVELSTLIPLRLGCKRLILVGDPKQLPATVFSKVAQKLGYDRSLFERLQLAGY------- 208
|
330
....*....|....
gi 2024463408 2353 lrrlPVVQLTVQYR 2366
Cdd:cd18042 209 ----PVLMLTTQYR 218
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
2046-2324 |
4.22e-69 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 233.39 E-value: 4.22e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2046 DQKRAIETAYamvkQHPGlakICLIHGPPGTGKSKTIVGLLSRVLrentrnekTSKKNAKIKQNRFLVCAPSNAAIDELM 2125
Cdd:pfam13086 1 SQREAIRSAL----SSSH---FTLIQGPPGTGKTTTIVELIRQLL--------SYPATSAAAGPRILVCAPSNAAVDNIL 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2126 KKIIiafkekcqnrqePLGNCGDIKLVRLGAERSINSEVRAFSLDKQVEHRMKRKP-TDRDQDIQKKKAALDEKLDMLSR 2204
Cdd:pfam13086 66 ERLL------------RKGQKYGPKIVRIGHPAAISEAVLPVSLDYLVESKLNNEEdAQIVKDISKELEKLAKALRAFEK 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2205 QRAMHRC----EKRESQMLDDEIGrLSKERQQLASQLKEVRghsQKVQTDIILESDIICCTLSTSGGGLLESafwrqgLD 2280
Cdd:pfam13086 134 EIIVEKLlksrNKDKSKLEQERRK-LRSERKELRKELRRRE---QSLEREILDEAQIVCSTLSGAGSRLLSS------LA 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2024463408 2281 PFSCVIVDEAGQSCEVETLIPLIHRCNKLVLVGDPRQLPPTIKS 2324
Cdd:pfam13086 204 NFDVVIIDEAAQALEPSTLIPLLRGPKKVVLVGDPKQLPPTVIS 247
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
2147-2545 |
5.22e-69 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 251.20 E-value: 5.22e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2147 GDIKLVRLGAERSINSEVRAFSLDKQVEHRMKRKPTDRDQDIQKKKAALDEKLDMLSRQRAMHRCEKRESQMLDDEIGRL 2226
Cdd:COG1112 427 LLLALALLAALLALLLLLAAALAALLALLLLLLLALAALLLLLAAAAALLALALLESLLEELIEEHPEELEKLIAELREA 506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2227 SKERQQLASQLKEVRGHSQKVQTDIILESDIICCTLSTSggglleSAFWRQGLDPFSCVIVDEAGQSCEVETLIPLIhRC 2306
Cdd:COG1112 507 ARLRRALRRELKKRRELRKLLWDALLELAPVVGMTPASV------ARLLPLGEGSFDLVIIDEASQATLAEALGALA-RA 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2307 NKLVLVGDPRQLPPTIKSIKAQ---EYGYGQSLMARLQRHLEEqvqnnllrrlPVVQLTVQYRMHPDICLFPSSYIYDKT 2383
Cdd:COG1112 580 KRVVLVGDPKQLPPVVFGEEAEevaEEGLDESLLDRLLARLPE----------RGVMLREHYRMHPEIIAFSNRLFYDGK 649
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2384 LKTDKATEENRCssEWPFQPYLVFDVgDGHEERDKDSFSNPQEVKLVLEIIRTIKEKRKDlgLRRIGIITPYSAQKKKIQ 2463
Cdd:COG1112 650 LVPLPSPKARRL--ADPDSPLVFIDV-DGVYERRGGSRTNPEEAEAVVELVRELLEDGPD--GESIGVITPYRAQVALIR 724
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2464 EELDRVFKNNSPG-EVDTVDAFQGREKDCIIVTCVRANSSK--GSIGFLAS-LQRLNVTITRARFSLFILGRLKTLMEQK 2539
Cdd:COG1112 725 ELLREALGDGLEPvFVGTVDRFQGDERDVIIFSLVYSNDEDvpRNFGFLNGgPRRLNVAVSRARRKLIVVGSRELLDSDP 804
|
....*.
gi 2024463408 2540 SFHLYK 2545
Cdd:COG1112 805 STPALK 810
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
2332-2530 |
8.48e-69 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 230.51 E-value: 8.48e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2332 YGQSLMARLQRHLEEqvqnnllrrlPVVQLTVQYRMHPDICLFPSSYIYDKTLKTDKATEENRCSSEW----PFQPYLVF 2407
Cdd:pfam13087 1 LDRSLFERLQELGPS----------AVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPLPDDFhlpdPLGPLVFI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2408 DVGDGHEERDK--DSFSNPQEVKLVLEIIRTIKEKRKDLGlRRIGIITPYSAQKKKIQEELDRVFKNNSPGEVDTVDAFQ 2485
Cdd:pfam13087 71 DVDGSEEEESDggTSYSNEAEAELVVQLVEKLIKSGPEEP-SDIGVITPYRAQVRLIRKLLKRKLGGKLEIEVNTVDGFQ 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2024463408 2486 GREKDCIIVTCVRANsSKGSIGFLASLQRLNVTITRARFSLFILG 2530
Cdd:pfam13087 150 GREKDVIIFSCVRSN-EKGGIGFLSDPRRLNVALTRAKRGLIIVG 193
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
1952-2541 |
2.78e-65 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 235.48 E-value: 2.78e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 1952 SRASGCLTRQKDQHTVCHLSVQTrgnlSFFVNNEVKCMVVGSLVPTQRSFKGLLLLSR--SPLAKPIINPSYsdfcPRDl 2029
Cdd:TIGR00376 74 SDLTGVVTRVGKRFITVALEESV----PQWSLKRVRIDLYANDVTFKRMKEALRALTEnhSRLLEFLLGREA----PSK- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2030 PVSSESATFCMNEYNEDQKRAIETAYamvkqhpGLAKICLIHGPPGTGKSKTIVGLLSRVLrentrnektsKKNAKIkqn 2109
Cdd:TIGR00376 145 ASEIHDFQFFDPNLNESQKEAVLFAL-------SSKDLFLIHGPPGTGKTRTVVELIRQLV----------KRGLRV--- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2110 rfLVCAPSNAAIDELMKKIIIAfkekcqnrqeplgncgDIKLVRLGAERSINSEVRAFSLDKQVEHRMKRKptdRDQDIQ 2189
Cdd:TIGR00376 205 --LVTAPSNIAVDNLLERLALC----------------DQKIVRLGHPARLLKSNKQHSLDYLIENHPKYQ---IVADIR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2190 KKKAALDEKLDML---SRQRAMHRCE---------KRESQMLDDEI----GRLSKERQQLASQLKEVRGHSQKVQTDIIL 2253
Cdd:TIGR00376 264 EKIDELIEERNKKtkpSPQKRRGLSDikilrkalkKREARGIESLKiasmAEWIETNKSIDRLLKLLPESEERIMNEILA 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2254 ESDIiccTLSTSGGGLLEsaFWRqgldpFSCVIVDEAGQSCEVETLIPLIhRCNKLVLVGDPRQLPPTIKSIKAQEygYG 2333
Cdd:TIGR00376 344 ESDA---TNSMAGSEILN--GQY-----FDVAVIDEASQAMEPSCLIPLL-KARKLILAGDHKQLPPTILSHDAEE--LS 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2334 QSLMARLQRHLEEQVQnnllrrlpvvQLTVQYRMHPDICLFPSSYIYDKTLKTDK-------------ATEENRCSSEWP 2400
Cdd:TIGR00376 411 LTLFERLIKEYPERSR----------TLNVQYRMNQKIMEFPSREFYNGKLTAHEsvanillrdlpkvEATESEDDLETG 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2401 fQPYLVFDV-GDGHEE-RDKDSFS--NPQEVKLVLEIIRTIkeKRKDLGLRRIGIITPYSAQ----KKKIQEELDRVfkn 2472
Cdd:TIGR00376 481 -IPLLFIDTsGCELFElKEADSTSkyNPGEAELVSEIIQAL--VKMGVPANDIGVITPYDAQvdllRQLLEHRHIDI--- 554
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024463408 2473 nspgEVDTVDAFQGREKDCIIVTCVRANsSKGSIGFLASLQRLNVTITRARFSLFILGRLKTLMEQKSF 2541
Cdd:TIGR00376 555 ----EVSSVDGFQGREKEVIIISFVRSN-RKGEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFY 618
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
2367-2539 |
1.38e-56 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 194.76 E-value: 1.38e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2367 MHPDICLFPSSYIYDKTLK--TDKATEENRCSSEWPFQPYLVFDVGDGHE-ERDKDSFSNPQEVKLVLEIIRTIKEKRkd 2443
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKagVSVAARLNPPPLPGPSKPLVFVDVSGGEErEESGTSKSNEAEAELVVELVKYLLKSG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2444 LGLRRIGIITPYSAQKKKIQEELDRVFKNNSPGEVDTVDAFQGREKDCIIVTCVRANSSKGSIGFLASLQRLNVTITRAR 2523
Cdd:cd18808 79 VKPSSIGVITPYRAQVALIRELLRKRGGLLEDVEVGTVDNFQGREKDVIILSLVRSNESGGSIGFLSDPRRLNVALTRAK 158
|
170
....*....|....*.
gi 2024463408 2524 FSLFILGRLKTLMEQK 2539
Cdd:cd18808 159 RGLIIVGNPDTLSKDP 174
|
|
| DEXXQc_UPF1 |
cd18039 |
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ... |
2042-2366 |
4.72e-42 |
|
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350797 [Multi-domain] Cd Length: 234 Bit Score: 155.10 E-value: 4.72e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2042 EYNEDQKRAIETAYamvkQHPglakICLIHGPPGTGK---SKTIVGLLSRvlrentrnektsKKNAKIkqnrfLVCAPSN 2118
Cdd:cd18039 1 ELNHSQVDAVKTAL----QRP----LSLIQGPPGTGKtvtSATIVYHLVK------------QGNGPV-----LVCAPSN 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2119 AAIDELMKKIiiafkekcqnrqeplGNCGdIKLVRLGAER--SINSEVRAFSLDKQVEHRMKRKptdrdqdiqkkkaald 2196
Cdd:cd18039 56 VAVDQLTEKI---------------HQTG-LKVVRLCAKSreAVESPVSFLALHNQVRNLDSAE---------------- 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2197 ekldmlsrqramhrcEKRESQMLDDEIGRLSKERQQLASQLKEvrghsqKVQTDIILESDIICCTLSTSGGGLLesafwr 2276
Cdd:cd18039 104 ---------------KLELLKLLKLETGELSSADEKRYRKLKR------KAERELLRNADVICCTCVGAGDPRL------ 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2277 qGLDPFSCVIVDEAGQSCEVETLIPLIHRCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARLqrhleeqVQNNLlrrL 2356
Cdd:cd18039 157 -SKMKFRTVLIDEATQATEPECLIPLVHGAKQVILVGDHCQLGPVVMCKKAAKAGLSQSLFERL-------VQLGI---R 225
|
330
....*....|
gi 2024463408 2357 PVVqLTVQYR 2366
Cdd:cd18039 226 PIR-LQVQYR 234
|
|
| DEXXQc_SMUBP2 |
cd18044 |
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ... |
2044-2366 |
1.08e-33 |
|
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350802 [Multi-domain] Cd Length: 191 Bit Score: 129.65 E-value: 1.08e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2044 NEDQKRAIETAyamVKQHPglakICLIHGPPGTGKSKTIVGLlsrVLRENTRNEktskknakikqnRFLVCAPSNAAIDE 2123
Cdd:cd18044 3 NDSQKEAVKFA---LSQKD----VALIHGPPGTGKTTTVVEI---ILQAVKRGE------------KVLACAPSNIAVDN 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2124 LMKKIIiafkekcqnrqeplgNCGdIKLVRLGaersinsevrafsldkqveHrmkrkPTdrdqdiqkkkaaldekldmls 2203
Cdd:cd18044 61 LVERLV---------------ALK-VKVVRIG-------------------H-----PA--------------------- 79
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2204 rqramhrcekresqmlddeigRLskerqqlasqLKEVRGHSqkvqTDIILESDIICCTLSTSGGGLLesafwrQGLDPFS 2283
Cdd:cd18044 80 ---------------------RL----------LESVLDHS----LDALVAAQVVLATNTGAGSRQL------LPNELFD 118
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2284 CVIVDEAGQSCEVETLIPLIhRCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARLQrhleeqvqnNLLRRLPVVQLTV 2363
Cdd:cd18044 119 VVVIDEAAQALEASCWIPLL-KARRCILAGDHKQLPPTILSDKAARGGLGVTLFERLV---------NLYGESVVRMLTV 188
|
...
gi 2024463408 2364 QYR 2366
Cdd:cd18044 189 QYR 191
|
|
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
2044-2366 |
5.31e-30 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 120.42 E-value: 5.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2044 NEDQKRAIETAYAMVKQHPGLakicLIHGPPGTGKSKTIVGLLSRVLRENtrnektskKNAKIkqnrfLVCAPSNAAIDE 2123
Cdd:cd18038 3 NDEQKLAVRNIVTGTSRPPPY----IIFGPPGTGKTVTLVEAILQVLRQP--------PEARI-----LVCAPSNSAADL 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2124 LMKKIIIAFKEKCQnrqeplgncgdikLVRLGA----ERSINSEVRAFSLDKQvehrmkrkptdrdqdiqkkkaalDEKL 2199
Cdd:cd18038 66 LAERLLNALVTKRE-------------ILRLNApsrdRASVPPELLPYCNSKA-----------------------EGTF 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2200 DMLSRQRAMHrcekresqmlddeigrlskerqqlasqlkevrghsqkvqtdiileSDIICCTLSTSGggLLESAFWRQGL 2279
Cdd:cd18038 110 RLPSLEELKK---------------------------------------------YRIVVCTLMTAG--RLVQAGVPNGH 142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2280 dpFSCVIVDEAGQSCEVETLIPLIHRCNK---LVLVGDPRQLPPTIKSIKAQEYGYGQSLMARL-QRHLEEQV--QNNLL 2353
Cdd:cd18038 143 --FTHIFIDEAGQATEPEALIPLSELASKntqIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLmERPLYYKDgeYNPSY 220
|
330
....*....|...
gi 2024463408 2354 rrlpVVQLTVQYR 2366
Cdd:cd18038 221 ----ITKLLKNYR 229
|
|
| DEXXc_HELZ2-C |
cd18040 |
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
2044-2341 |
3.67e-24 |
|
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350798 [Multi-domain] Cd Length: 271 Bit Score: 104.53 E-value: 3.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2044 NEDQKRAIETAYAmvkqHPglakICLIHGPPGTGKSKTIVGLLSRVLRENtrNEKTSKKNAKIKQNRFLVCAPSNAAID- 2122
Cdd:cd18040 3 NPSQNHAVRTALT----KP----FTLIQGPPGTGKTVTGVHIAYWFAKQN--REIQSVSGEGDGGPCVLYCGPSNKSVDv 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2123 --ELMK-----KIIIAFKEKCQNRQEPLGNCGDIKLVRLGAERSINSEVRAFSLdkqvEHRMKRKPTDRDQDIqkkkaal 2195
Cdd:cd18040 73 vaELLLkvpglKILRVYSEQIETTEYPIPNEPRHPNKKSERESKPNSELSSITL----HHRIRQPSNPHSQQI------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2196 dekldmlsrqRAMHRCEKRESQMLDDEigRLSKERQQL-ASQLKEVRGHsqkvqtdiilesDIICCTLSTSGGGLLESAF 2274
Cdd:cd18040 142 ----------KAFEARFERTQEKITEE--DIKTYKILIwEARFEELETV------------DVILCTCSEAASQKMRTHA 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024463408 2275 wrqgldPFSCVIVDEAGQSCEVETLIPLI--HRCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARLQ 2341
Cdd:cd18040 198 ------NVKQCIVDECGMCTEPESLIPIVsaPRAEQVVLIGDHKQLRPVVQNKEAQKLGLGRSLFERYA 260
|
|
| DEXXQc_DNA2 |
cd18041 |
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ... |
2044-2366 |
4.23e-23 |
|
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350799 [Multi-domain] Cd Length: 203 Bit Score: 99.62 E-value: 4.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2044 NEDQKRAIETAYamvkqhpgLAK-ICLIHGPPGTGKSKTIVgLLSRVLRENtrnektskknakikQNRFLVCAPSNAAID 2122
Cdd:cd18041 3 NKDQRQAIKKVL--------NAKdYALILGMPGTGKTTTIA-ALVRILVAL--------------GKSVLLTSYTHSAVD 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2123 ELMKKIIIAfkekcqnrqeplgncgDIKLVRLGAERSINSEVRAFSLDKqvehrmKRKPTDRDQDIQkkkaaldekldml 2202
Cdd:cd18041 60 NILLKLKKF----------------GVNFLRLGRLKKIHPDVQEFTLEA------ILKSCKSVEELE------------- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2203 srqramhrcekresqmlddeigrlskerqqlasqlkevrghsqkvqtDIILESDIICCTLStsggGLLESAFWRQgldPF 2282
Cdd:cd18041 105 -----------------------------------------------SKYESVSVVATTCL----GINHPIFRRR---TF 130
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2283 SCVIVDEAGQSCEVETLIPLIHrCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARLqrhleEQVQNNllrrlPVVQLT 2362
Cdd:cd18041 131 DYCIVDEASQITLPICLGPLRL-AKKFVLVGDHYQLPPLVKSREARELGMDESLFKRL-----SEAHPD-----AVVQLT 199
|
....
gi 2024463408 2363 VQYR 2366
Cdd:cd18041 200 IQYR 203
|
|
| DEXXQc_Mov10L1 |
cd18078 |
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ... |
2044-2366 |
2.26e-18 |
|
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350836 [Multi-domain] Cd Length: 230 Bit Score: 86.65 E-value: 2.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2044 NEDQKRAIETAyamvkqhpgLAKIC-----LIHGPPGTGKSKTIVGLLSRVLREntrnektskknakIKQNRFLVCAPSN 2118
Cdd:cd18078 3 NELQKEAVKRI---------LGGECrplpyILFGPPGTGKTVTIIEAILQVVYN-------------LPRSRILVCAPSN 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2119 AAIDELMKKIIiafkekcqnrqeplgncgDIKLVRLGAersinsevrafsldkqvehrmkrkptdrdqdiqkkkaaldek 2198
Cdd:cd18078 61 SAADLVTSRLH------------------ESKVLKPGD------------------------------------------ 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2199 ldmLSRQRAMHRcekRESQMLDDEI-GRLSKERQQLASQLkevrghsqkvqtdiilesDIICCTLSTSGggllesAFWRQ 2277
Cdd:cd18078 81 ---MVRLNAVNR---FESTVIDARKlYCRLGEDLSKASRH------------------RIVISTCSTAG------LLYQM 130
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2278 GLDP--FSCVIVDEAGQSCEVETLIPL--IH-RCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARL------QRHLEE 2346
Cdd:cd18078 131 GLPVghFTHVFVDEAGQATEPESLIPLglISsRDGQIILAGDPMQLGPVIKSRLASAYGLGVSFLERLmnrplyLRDPNR 210
|
330 340
....*....|....*....|
gi 2024463408 2347 QVQNNLLRRLPVVQLTVQYR 2366
Cdd:cd18078 211 FGESGGYNPLLVTKLVDNYR 230
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
2280-2366 |
1.00e-17 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 81.13 E-value: 1.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2280 DPFSCVIVDEAGQSCEVETLIPlIHRCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARLQRHLEeqvqnnlLRRLPVV 2359
Cdd:cd17934 43 DNVDVVIIDEASQITEPELLIA-LIRAKKVVLVGDPKQLPPVVQEDHAALLGLSFILSLLLLFRLL-------LPGSPKV 114
|
....*..
gi 2024463408 2360 QLTVQYR 2366
Cdd:cd17934 115 MLDTQYR 121
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
2254-2378 |
2.16e-13 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 71.30 E-value: 2.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2254 ESDIICCT---LSTSGGGLLESAFwrqgldPFSCVIVDEAGQSCEVETLIPLI--------HRCNKLVLVGDPRQLPPTI 2322
Cdd:cd17935 86 GAKIIAMTcthAALKRGELVELGF------KYDNILMEEAAQILEIETFIPLLlqnpedgpNRLKRLIMIGDHHQLPPVI 159
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2323 KSIKAQEYGY-GQSLMARlqrhleeqvqnnlLRRL--PVVQLTVQYRMHPDIC-LFPSSY 2378
Cdd:cd17935 160 KNMAFQKYSNmEQSLFTR-------------LVRLgvPTVDLDAQGRARASISsLYNWRY 206
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
2445-2530 |
8.40e-12 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 63.23 E-value: 8.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2445 GLRRIGIITPYSAQKKKIQEELDRVFKNNSP---GEVDTVDAFQGREKDCIIVTCVRANSSkgsigflaSLQRLNVTITR 2521
Cdd:cd18786 9 GLYKGVVLTPYHRDRAYLNQYLQGLSLDEFDlqlVGAITIDSSQGLTFDVVTLYLPTANSL--------TPRRLYVALTR 80
|
....*....
gi 2024463408 2522 ARFSLFILG 2530
Cdd:cd18786 81 ARKRLVIYD 89
|
|
| DEXXQc_HELZ |
cd18077 |
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that ... |
2044-2343 |
9.17e-10 |
|
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. HELZ is a member of the family I class of RNA helicases of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350835 [Multi-domain] Cd Length: 226 Bit Score: 61.35 E-value: 9.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2044 NEDQKRAIE--TAYAMVKQHPglakiCLIHGPPGTGKSKTIVGLLSRVLREntrnektskknakiKQNRFLVCAPSNAAI 2121
Cdd:cd18077 3 NAKQKEAVLaiTTPLSIQLPP-----VLLIGPFGTGKTFTLAQAVKHILQQ--------------PETRILICTHSNSAA 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2122 DELMKKIIIAFKEKCQNRQEPLGncgdiKLVRLGAERSINSEVRAFSLDKqvEHRMKRKPTDrdQDIQKkkaaldekldm 2201
Cdd:cd18077 64 DLYIKEYLHPYVETGNPRARPLR-----VYYRNRWVKTVHPVVQKYCLID--EHGTFRMPTR--EDVMR----------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2202 lsrqramHRcekresqmlddeigrlskerqqlasqlkevrghsqkvqtdiilesdIICCTLSTSggglleSAFWRQGLDP 2281
Cdd:cd18077 124 -------HR----------------------------------------------VVVVTLSTS------QYLCQLDLEP 144
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024463408 2282 --FSCVIVDEAGQSCEVETLIP--LIHRCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARLQRH 2343
Cdd:cd18077 145 gfFTHILLDEAAQAMECEAIMPlaLATKSTRIVLAGDHMQLSPEVYSEFARERNLHISLLERLYEH 210
|
|
| DEXXQc_SF1 |
cd18043 |
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ... |
2282-2322 |
1.27e-08 |
|
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350801 [Multi-domain] Cd Length: 127 Bit Score: 55.28 E-value: 1.27e-08
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 2024463408 2282 FSCVIVDEAGQsCEVETLIPLIHRCNKLVLVGDPRQLPPTI 2322
Cdd:cd18043 81 FDLVIFDEASQ-IPIEEALPALFRGKQVVVVGDDKQLPPSI 120
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
2273-2365 |
2.62e-07 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 51.72 E-value: 2.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2273 AFWRQGLDPFSCVIVDEAGQSCEVET--LIPLIHRCNKLVLVGDPRQLPPTIKSIKAQEYGYGQSLMARLQRHleeqvqn 2350
Cdd:cd17914 38 TPTNKAAAQLDNILVDEAAQILEPETsrLIDLALDQGRVILVGDHDQLGPVWRGAVLAKICNEQSLFTRLVRL------- 110
|
90
....*....|....*
gi 2024463408 2351 nllrRLPVVQLTVQY 2365
Cdd:cd17914 111 ----GVSLIRLQVQY 121
|
|
| EEXXEc_NFX1 |
cd17936 |
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ... |
2249-2365 |
5.04e-07 |
|
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350694 [Multi-domain] Cd Length: 178 Bit Score: 52.16 E-value: 5.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2249 TDII-LESDIICCTlsTSGGGLLESAFwrQGLDPfSCVIVDEAGQSCEVETLIPLIHRCNKLVLVGDPRQLPPTIKS--I 2325
Cdd:cd17936 75 TKIVrLGARVIGMT--TTGAAKYRELL--QALGP-KVVIVEEAAEVLEAHILAALTPSTEHLILIGDHKQLRPKVNVyeL 149
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2024463408 2326 KAQEYGYGQSLMARLqrhleeqVQNNllrrLPVVQLTVQY 2365
Cdd:cd17936 150 TAKKYNLDVSLFERL-------VKNG----LPFVTLNVQR 178
|
|
| SEN1_N |
pfam12726 |
SEN1 N terminal; This domain is found at the N terminal of the helicase SEN1. SEN1 is a Pol II ... |
38-327 |
9.89e-07 |
|
SEN1 N terminal; This domain is found at the N terminal of the helicase SEN1. SEN1 is a Pol II termination factor for noncoding RNA genes. The N terminal of SEN1, unlike the C terminal, is not required for growth.
Pssm-ID: 432746 Cd Length: 744 Bit Score: 54.25 E-value: 9.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 38 LCYCLECVVEYHKAR-------------EKLPSLHQVLLELETSRLVAHIEKSirEEAGEDDELFIVDENGETQLPVYvg 104
Cdd:pfam12726 9 LSSCDKCVRNFHRGKkelrqtfaerfpeETVAQFLDKLDEWDIERILPGLDKA--KEILEKRGIFSKSSLSSHLKEVL-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 105 pdfennlrVPLLEVLKYP-YLLLHEKVSELCVEVLCRMEENHTSFQVFEKYPGIYLFLVHPNEVIRRWAiltARNLGKVD 183
Cdd:pfam12726 85 --------LALYEALCCPpYLRSDPELRALFDYVFKLLQTKKKPLRLGTLLPGMTYFLFDGDPEERRWA---RRQLERLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 184 RDDYydLQEVLTclfkVIELGLFE-SPDIYRSSviekgklillpshlYDNSNYKNYWLGICMLLTVLEEQAMDSLLLGPD 262
Cdd:pfam12726 154 RSLT--PEEFDW----AVHDLLEEaIVHLSNIQ--------------LDPSFIERFWSGFSLILRLLDKDLITHRLRALE 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024463408 263 KQNDFmQSILHTMEKEADDDSTDPFWPALHCFMVILDQLGSKVWGQL--IDPVQAFQTIINSVSYNN 327
Cdd:pfam12726 214 VNPPI-EDIYRLLLNHLSSTLDPPLPDLLRALSLLLEKSGKAFWDAMgpISPQVVLDQIFDNPAFAK 279
|
|
| CoV_Nsp13-helicase |
cd21718 |
helicase domain of coronavirus non-structural protein 13; This model represents the helicase ... |
2305-2531 |
1.44e-06 |
|
helicase domain of coronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from alpha-, beta-, gamma-, and deltacoronavirus, including pathogenic human viruses such as Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV2 (also called 2019 novel CoV or 2019-nCoV), and Middle East respiratory syndrome-related (MERS) CoV. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409652 [Multi-domain] Cd Length: 341 Bit Score: 52.92 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2305 RCNKLVLVGDPRQLPP-----TIKSIKAQEYGYGQSLMARLQrhleeqvqnnllrrlPVVQLTVQYRMHPDICLFPSSYI 2379
Cdd:cd21718 142 KYKHIVYVGDPAQLPAprtllTEGSLEPKDYNVVTRLMVGSG---------------PDVFLSKCYRCPKEIVDTVSKLV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2380 YDKTLKTDKATEEnrcssewpfQPYLVFDVGD-GHEerDKDSFSNPQevklvLEIIRTIKEKRKDLglRRIGIITPYSAQ 2458
Cdd:cd21718 207 YDNKLKAIKPKSR---------QCFKTFGKGDvRHD--NGSAINRPQ-----LEFVKRFLDRNPRW--RKAVFISPYNAM 268
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024463408 2459 KKKIQEELDRvfknnspgEVDTVDAFQGREKDCIIVtCVRANSSKGSigflaSLQRLNVTITRARFSLFILGR 2531
Cdd:cd21718 269 NNRASRLLGL--------STQTVDSSQGSEYDYVIF-CQTTDTAHAL-----NINRFNVAITRAKHGILVIMR 327
|
|
| DEXXQc_SF1 |
cd18043 |
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ... |
2044-2131 |
1.62e-06 |
|
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350801 [Multi-domain] Cd Length: 127 Bit Score: 49.50 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2044 NEDQKRAIETAYamvkQHPGLakicLIHGPPGTGKSKTIVGLLSrvlrentrnektskkNAKIKQNRFLVCAPSNAAIDE 2123
Cdd:cd18043 1 DSSQEAAIISAR----NGKNV----VIQGPPGTGKSQTIANIIA---------------NALARGKRVLFVSEKKAALDV 57
|
....*...
gi 2024463408 2124 LMKKIIIA 2131
Cdd:cd18043 58 VRFPCWIM 65
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
2269-2320 |
1.85e-04 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 44.86 E-value: 1.85e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 2024463408 2269 LLESAFWRQGLDPFSCVIVDEAGQ--SCEVETLIPLIHRCN-KLVLVGDPRQLPP 2320
Cdd:pfam13604 76 LLHRLGGRAGLDPGTLLIVDEAGMvgTRQMARLLKLAEDAGaRVILVGDPRQLPS 130
|
|
| deltaCoV_Nsp13-helicase |
cd21721 |
helicase domain of deltacoronavirus non-structural protein 13; This model represents the ... |
2307-2531 |
2.80e-04 |
|
helicase domain of deltacoronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from deltacoronavirus, including Bulbul coronavirus (CoV) HKU11 and Common moorhen CoV HKU21. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409654 [Multi-domain] Cd Length: 342 Bit Score: 45.69 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2307 NKLVLVGDPRQLPP-----TIKSIKAQEYGYGQSLMarlqrhleeqVQNNllrrlPVVQLTVQYRMHPDICLFPSSYIYD 2381
Cdd:cd21721 144 NHIVYVGDPYQLPSprtmlTTGQLSPADYNVVTDIM----------VHAG-----ADVMLDMCYRCPREIVDTVSKLVYD 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2382 KTLKTDKAteenrcSSEWPFQPYLVFDVGD-GHEerDKDSFSNPQeVKLVLEIirtikekRKDLGLRRIGIITPYSAQKk 2460
Cdd:cd21721 209 NKLKAAKP------NSRQCYKTIINNGNNDiAHE--GQSAYNEPQ-LRFALAF-------RQYKRWDNVTFISPYNAMN- 271
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024463408 2461 kiqeeldrvFKNNSPG-EVDTVDAFQGREKDCIIVtCVRANSskgsiGFLASLQRLNVTITRARFSLFILGR 2531
Cdd:cd21721 272 ---------VKAAMAGfSTQTVDSSQGSEYDYVIF-CVTTDS-----AHALNMSRLNVALTRAKIGILVVFR 328
|
|
| gammaCoV_Nsp13-helicase |
cd21720 |
helicase domain of gammacoronavirus non-structural protein 13; This model represents the ... |
2309-2531 |
3.89e-04 |
|
helicase domain of gammacoronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from gammacoronavirus, including Avian infectious bronchitis virus. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. Coronavirus (CoV) Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409653 [Multi-domain] Cd Length: 343 Bit Score: 45.29 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2309 LVLVGDPRQLPPT----IKSIKAQEYGYGQSLMARLQrhleeqvqnnllrrlPVVQLTVQYRMHPDICLFPSSYIYDKTL 2384
Cdd:cd21720 146 VVYVGDPAQLPAPrtllNGSLSPKDYNVVTNLMVCVK---------------PDIFLAKCYRCPKEIVDTVSTLVYDGKF 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2385 KTDKaTEENRCssewpFQpyLVFDVGDGHEERDKDSFSNPQEVKLVLEIIRTIKEKRKDLglrrigIITPYSAQKKKIQE 2464
Cdd:cd21720 211 IANN-PESRQC-----FK--VIVNNGNSDVGHESGSAYNTTQLEFVKDFVCRNKEWREAT------FISPYNAMNQRAYR 276
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024463408 2465 ELDRvfknnspgEVDTVDAFQGREKDCIIVtCVRANSSKGsigflASLQRLNVTITRARFSLFILGR 2531
Cdd:cd21720 277 MLGL--------NVQTVDSSQGSEYDYVIF-CVTADSQHA-----LNINRFNVALTRAKRGILVVMR 329
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
2047-2124 |
4.66e-04 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 42.59 E-value: 4.66e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024463408 2047 QKRAIETAYAmvkqhpglAKICLIHGPPGTGKSKTIVGLLSRVLRENTRNektskknakikqNRFLVCAPSNAAIDEL 2124
Cdd:pfam13245 1 QREAVRTALP--------SKVVLLTGGPGTGKTTTIRHIVALLVALGGVS------------FPILLAAPTGRAAKRL 58
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
2069-2124 |
2.01e-03 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 40.55 E-value: 2.01e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 2024463408 2069 LIHGPPGTGKSKTIVGLLSRVLRentrnektskkNAKIKQNRFLVCAPSNAAIDEL 2124
Cdd:cd17914 3 LIQGPPGTGKTRVLVKIVAALMQ-----------NKNGEPGRILLVTPTNKAAAQL 47
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
2042-2120 |
2.67e-03 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 43.04 E-value: 2.67e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024463408 2042 EYNEDQKRAIETAyamVKQHpglaKICLIHGPPGTGKSKTIVGLLsRVLREntrnektskknakiKQNRFLVCAPSNAA 2120
Cdd:COG0507 124 TLSDEQREAVALA---LTTR----RVSVLTGGAGTGKTTTLRALL-AALEA--------------LGLRVALAAPTGKA 180
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
2042-2126 |
3.84e-03 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 41.01 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2042 EYNEDQKRAIETAYAmvkqhpGLAKICLIHGPPGTGKSkTIVGLLSRVLRENTRnektskknakikqnRFLVCAPSNAAI 2121
Cdd:pfam13604 1 TLNAEQAAAVRALLT------SGDRVAVLVGPAGTGKT-TALKALREAWEAAGY--------------RVIGLAPTGRAA 59
|
....*
gi 2024463408 2122 DELMK 2126
Cdd:pfam13604 60 KVLGE 64
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
2044-2317 |
8.25e-03 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 40.69 E-value: 8.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2044 NEDQKRAIETayamvkqhpgLAKICLIHGPPGTGKSKTIVGLLSRVLRENtrnektskknaKIKQNRFLVCAPSNAAIDE 2123
Cdd:pfam00580 2 NPEQRKAVTH----------LGGPLLVLAGAGSGKTRVLTERIAYLILEG-----------GIDPEEILAVTFTNKAARE 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2124 LMKKIIIAFKEKCQnrQEPL-----GNCGDIkLVRLGAERSINSEVRAFSLDKQVEHrMKrkptdrdQDIQKKKAALDEK 2198
Cdd:pfam00580 61 MKERILKLLGKAEL--SELNistfhSFCLRI-LRKYANRIGLLPNFSILDELDQLAL-LK-------ELLEKDRLNLDPK 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024463408 2199 ldmLSRQRAMH----RCEKRESQMLDDEIGRLSKERQQLASQLKEVrgHSQKVQTDIILESDIIC--CTLSTSGGGLLEs 2272
Cdd:pfam00580 130 ---LLRKLELKelisKAKNRLLSPEELQQGAADPRDKLAAEFYQEY--QERLKENNALDFDDLLLltLELLRSDPELLE- 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2024463408 2273 aFWRQgldPFSCVIVDEAGQSCEV-ETLIPLI-HRCNKLVLVGDPRQ 2317
Cdd:pfam00580 204 -AYRE---RFKYILVDEFQDTNPIqYRLLKLLaGGHENLFLVGDPDQ 246
|
|
| |
