NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|2024476542|ref|XP_040544058|]

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myelin transcription factor 1 isoform X6 [Gallus gallus]

Protein Classification

MYT1 and zf-C2HC domain-containing protein( domain architecture ID 10479154)

protein containing domains MYT1, zf-C2HC, and Com_YlbF

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MYT1 super family

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...

595-826

3.10e-80

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.

The actual alignment was detected with superfamily member pfam08474:

Pssm-ID: 462489 [Multi-domain] Cd Length: 237 Bit Score: 262.38 E-value: 3.10e-80

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024476542  595 YRPNMVPATPRANLAKELEKYSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFKC----------------------- 651
Cdd:pfam08474    1 YRNNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPKGFDAkkyfckpsspsssltssyapsss 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024476542  652 ------FDYSHDAEAAHMAATAILNLSTRCWEMPENLSTKQQEAPGKSMDIEVDENGTLDLSMNKNRKRESTFPSSSSCS 725
Cdd:pfam08474   81 ssssssYDYTHDMEAAHMAATAILNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRGVTSGSVLTPL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024476542  726 SSPSvkspdvSQRQnstsatSSTMTSPQSSQTSRQDEWDGPIDYTKPNRQREEEpeesepaahsfaSSEADEQEVSEENF 805
Cdd:pfam08474  161 PPMS------PQRQ------ASLLNSRCYQALCAQDCWDLPVDYTKIKRIDEEE------------KEEPEDLDPFQELL 216

                          250       260
                   ....*....|....*....|.
gi 2024476542  806 EERKYPGEVTLTNFKLKFLSK 826
Cdd:pfam08474  217 EERKYPGEVTIPSPKPKYPPC 237

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

855-883

9.50e-17

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

:

Pssm-ID: 460240 Cd Length: 29 Bit Score: 74.49 E-value: 9.50e-17

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  855 RCPTPGCDGSGHITGNYASHRSLSGCPRA 883
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

904-932

1.42e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

:

Pssm-ID: 460240 Cd Length: 29 Bit Score: 68.33 E-value: 1.42e-14

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  904 KCPVPGCVGLGHISGKYASHRSASGCPLA 932
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

72-99

1.52e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

:

Pssm-ID: 460240 Cd Length: 29 Bit Score: 68.33 E-value: 1.52e-14

                           10        20
                   ....*....|....*....|....*...
gi 2024476542   72 CPTPGCNGSGHIRGKYARHRSLQSCPLA 99
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

957-985

1.73e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

:

Pssm-ID: 460240 Cd Length: 29 Bit Score: 67.94 E-value: 1.73e-14

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  957 TCPTPGCDGSGHANGSFLTHRSLSGCPRA 985
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

520-548

3.93e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

:

Pssm-ID: 460240 Cd Length: 29 Bit Score: 67.17 E-value: 3.93e-14

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  520 KCPTPGCTGQGHVNSNRNTHRSLSGCPIA 548
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

476-502

4.73e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

:

Pssm-ID: 460240 Cd Length: 29 Bit Score: 66.79 E-value: 4.73e-14

                           10        20
                   ....*....|....*....|....*..
gi 2024476542  476 KCPTPGCDGTGHVTGLYPHHRSLSGCP 502
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27

PLN02713 super family

Probable pectinesterase/pectinesterase inhibitor

527-572

7.02e-03

Probable pectinesterase/pectinesterase inhibitor

The actual alignment was detected with superfamily member PLN02713:

Pssm-ID: 215383 [Multi-domain] Cd Length: 566 Bit Score: 40.55 E-value: 7.02e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2024476542  527 TGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQTQSGDPSKPSS 572
Cdd:PLN02713   432 TAQGRTDPNQNTGTSIQNCTIKAADDLASSNYTVKTYLGRPWKEYS 477

Name

Accession

Description

Interval

E-value

MYT1

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...

595-826

3.10e-80

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.

Pssm-ID: 462489 [Multi-domain] Cd Length: 237 Bit Score: 262.38 E-value: 3.10e-80

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024476542  595 YRPNMVPATPRANLAKELEKYSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFKC----------------------- 651
Cdd:pfam08474    1 YRNNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPKGFDAkkyfckpsspsssltssyapsss 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024476542  652 ------FDYSHDAEAAHMAATAILNLSTRCWEMPENLSTKQQEAPGKSMDIEVDENGTLDLSMNKNRKRESTFPSSSSCS 725
Cdd:pfam08474   81 ssssssYDYTHDMEAAHMAATAILNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRGVTSGSVLTPL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024476542  726 SSPSvkspdvSQRQnstsatSSTMTSPQSSQTSRQDEWDGPIDYTKPNRQREEEpeesepaahsfaSSEADEQEVSEENF 805
Cdd:pfam08474  161 PPMS------PQRQ------ASLLNSRCYQALCAQDCWDLPVDYTKIKRIDEEE------------KEEPEDLDPFQELL 216

                          250       260
                   ....*....|....*....|.
gi 2024476542  806 EERKYPGEVTLTNFKLKFLSK 826
Cdd:pfam08474  217 EERKYPGEVTIPSPKPKYPPC 237

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

855-883

9.50e-17

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 74.49 E-value: 9.50e-17

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  855 RCPTPGCDGSGHITGNYASHRSLSGCPRA 883
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

904-932

1.42e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 68.33 E-value: 1.42e-14

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  904 KCPVPGCVGLGHISGKYASHRSASGCPLA 932
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

72-99

1.52e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 68.33 E-value: 1.52e-14

                           10        20
                   ....*....|....*....|....*...
gi 2024476542   72 CPTPGCNGSGHIRGKYARHRSLQSCPLA 99
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

957-985

1.73e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 67.94 E-value: 1.73e-14

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  957 TCPTPGCDGSGHANGSFLTHRSLSGCPRA 985
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

520-548

3.93e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 67.17 E-value: 3.93e-14

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  520 KCPTPGCTGQGHVNSNRNTHRSLSGCPIA 548
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

476-502

4.73e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 66.79 E-value: 4.73e-14

                           10        20
                   ....*....|....*....|....*..
gi 2024476542  476 KCPTPGCDGTGHVTGLYPHHRSLSGCP 502
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27

PLN02713

Probable pectinesterase/pectinesterase inhibitor

527-572

7.02e-03

Probable pectinesterase/pectinesterase inhibitor

Pssm-ID: 215383 [Multi-domain] Cd Length: 566 Bit Score: 40.55 E-value: 7.02e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2024476542  527 TGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQTQSGDPSKPSS 572
Cdd:PLN02713   432 TAQGRTDPNQNTGTSIQNCTIKAADDLASSNYTVKTYLGRPWKEYS 477

Name

Accession

Description

Interval

E-value

MYT1

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...

595-826

3.10e-80

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.

Pssm-ID: 462489 [Multi-domain] Cd Length: 237 Bit Score: 262.38 E-value: 3.10e-80

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024476542  595 YRPNMVPATPRANLAKELEKYSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFKC----------------------- 651
Cdd:pfam08474    1 YRNNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPKGFDAkkyfckpsspsssltssyapsss 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024476542  652 ------FDYSHDAEAAHMAATAILNLSTRCWEMPENLSTKQQEAPGKSMDIEVDENGTLDLSMNKNRKRESTFPSSSSCS 725
Cdd:pfam08474   81 ssssssYDYTHDMEAAHMAATAILNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRGVTSGSVLTPL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024476542  726 SSPSvkspdvSQRQnstsatSSTMTSPQSSQTSRQDEWDGPIDYTKPNRQREEEpeesepaahsfaSSEADEQEVSEENF 805
Cdd:pfam08474  161 PPMS------PQRQ------ASLLNSRCYQALCAQDCWDLPVDYTKIKRIDEEE------------KEEPEDLDPFQELL 216

                          250       260
                   ....*....|....*....|.
gi 2024476542  806 EERKYPGEVTLTNFKLKFLSK 826
Cdd:pfam08474  217 EERKYPGEVTIPSPKPKYPPC 237

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

855-883

9.50e-17

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 74.49 E-value: 9.50e-17

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  855 RCPTPGCDGSGHITGNYASHRSLSGCPRA 883
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

904-932

1.42e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 68.33 E-value: 1.42e-14

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  904 KCPVPGCVGLGHISGKYASHRSASGCPLA 932
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

72-99

1.52e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 68.33 E-value: 1.52e-14

                           10        20
                   ....*....|....*....|....*...
gi 2024476542   72 CPTPGCNGSGHIRGKYARHRSLQSCPLA 99
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

957-985

1.73e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 67.94 E-value: 1.73e-14

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  957 TCPTPGCDGSGHANGSFLTHRSLSGCPRA 985
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

520-548

3.93e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 67.17 E-value: 3.93e-14

                           10        20
                   ....*....|....*....|....*....
gi 2024476542  520 KCPTPGCTGQGHVNSNRNTHRSLSGCPIA 548
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29

zf-C2HC

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

476-502

4.73e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.

Pssm-ID: 460240 Cd Length: 29 Bit Score: 66.79 E-value: 4.73e-14

                           10        20
                   ....*....|....*....|....*..
gi 2024476542  476 KCPTPGCDGTGHVTGLYPHHRSLSGCP 502
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27

PLN02713

Probable pectinesterase/pectinesterase inhibitor

527-572

7.02e-03

Probable pectinesterase/pectinesterase inhibitor

Pssm-ID: 215383 [Multi-domain] Cd Length: 566 Bit Score: 40.55 E-value: 7.02e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2024476542  527 TGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQTQSGDPSKPSS 572
Cdd:PLN02713   432 TAQGRTDPNQNTGTSIQNCTIKAADDLASSNYTVKTYLGRPWKEYS 477

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
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Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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