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Conserved domains on  [gi|2024478201|ref|XP_040544838|]
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proton-associated sugar transporter A isoform X6 [Gallus gallus]

Protein Classification

SLC45 family MFS transporter( domain architecture ID 13022743)

SLC45 (solute carrier 45) family major facilitator superfamily (MFS) transporter facilitates the transport of sugars such as sucrose, glucose, and maltose into the cell, with the concomitant uptake of protons (symport system)

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020|GO:0015293
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 34-660 8.43e-101

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 315.34  E-value: 8.43e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  34 GYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALFGLSLMLNGRDIG 113
Cdd:cd17313    14 GWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAALGLILIPNAADIG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 114 SALSDtvNNHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDRGLNIHALLAGLGGGFGYVIGGIHWDKTSFG 193
Cdd:cd17313    94 LALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 194 KAVGGQLRVIYVFTSIILTITTVLTLISIPERPLGSfsrkkkvmkspslplppspplffeegvnenfasrnsdhlyasft 273
Cdd:cd17313   172 FALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSP-------------------------------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 274 spvsplspltpkygsfvsrdnsltginefassfgtsnidsvlidcftgghssylalpaslprqpvsvsfprvpdgcyqqe 353
Cdd:cd17313       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 354 ngilEQGERSIIPGPDGEALRVGSLDAIKPRssgilkrpqslaipdivtghcpessrrrnvtfsqqvanilldgvkyese 433
Cdd:cd17313   208 ----EAGEHSENPSLGEVLKSLLKLLKIMPR------------------------------------------------- 234

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 434 lngsgetseqplSMRLLCstichmpralrnlcINHFLGWLSFEGMLLFYTDFMGEVVFEGNPKAphnsdeYQKYNAGVTM 513
Cdd:cd17313   235 ------------SLLRLL--------------LVIFFWWIAFFPFELFFTDYMGEEVYHGTSAA------SSHYGAGVRM 282

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 514 GCWGMCIYAFSAAFYSAALEKLEERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFATLCTLPYSLLCDY 593
Cdd:cd17313   283 GAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDY 362

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024478201 594 yqscefagshTEGTRRGMGVDISLLSCQYFLAQILVALAMGPL--TTAVGSASGTMYFASLVSFLGCLF 660
Cdd:cd17313   363 ----------HSESGRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 34-660 8.43e-101

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 315.34  E-value: 8.43e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  34 GYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALFGLSLMLNGRDIG 113
Cdd:cd17313    14 GWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAALGLILIPNAADIG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 114 SALSDtvNNHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDRGLNIHALLAGLGGGFGYVIGGIHWDKTSFG 193
Cdd:cd17313    94 LALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 194 KAVGGQLRVIYVFTSIILTITTVLTLISIPERPLGSfsrkkkvmkspslplppspplffeegvnenfasrnsdhlyasft 273
Cdd:cd17313   172 FALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSP-------------------------------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 274 spvsplspltpkygsfvsrdnsltginefassfgtsnidsvlidcftgghssylalpaslprqpvsvsfprvpdgcyqqe 353
Cdd:cd17313       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 354 ngilEQGERSIIPGPDGEALRVGSLDAIKPRssgilkrpqslaipdivtghcpessrrrnvtfsqqvanilldgvkyese 433
Cdd:cd17313   208 ----EAGEHSENPSLGEVLKSLLKLLKIMPR------------------------------------------------- 234

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 434 lngsgetseqplSMRLLCstichmpralrnlcINHFLGWLSFEGMLLFYTDFMGEVVFEGNPKAphnsdeYQKYNAGVTM 513
Cdd:cd17313   235 ------------SLLRLL--------------LVIFFWWIAFFPFELFFTDYMGEEVYHGTSAA------SSHYGAGVRM 282

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 514 GCWGMCIYAFSAAFYSAALEKLEERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFATLCTLPYSLLCDY 593
Cdd:cd17313   283 GAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDY 362

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024478201 594 yqscefagshTEGTRRGMGVDISLLSCQYFLAQILVALAMGPL--TTAVGSASGTMYFASLVSFLGCLF 660
Cdd:cd17313   363 ----------HSESGRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 34-156 1.81e-18

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 88.71  E-value: 1.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  34 GYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALFGLSLMLNGRDIG 113
Cdd:TIGR01301  19 GWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGAALVAFAVILIGFAADIG 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2024478201 114 SALSDTVN--NHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVC 156
Cdd:TIGR01301  99 HLFGDNLDkkTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLT 143
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
34-107 1.32e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 70.32  E-value: 1.32e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024478201  34 GYAMETAYVTPVLLQ-MGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVgaLFGLSLML 107
Cdd:COG2211    25 AFGLLSAYLLYFYTDvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAI--PLALSFVL 97
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 41-161 8.91e-05

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 45.38  E-value: 8.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  41 YVTPVLlqmGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALFGLSLMLNGRDIGSALSDTv 120
Cdd:pfam13347  23 FYTDVL---GLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILLFTPPELGRAPLFI- 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2024478201 121 nnhkWGIVLTVCGVVLMDFSadsaDNPSHAYMMDVCSPMDQ 161
Cdd:pfam13347  99 ----WLLATYILLRIAYTFF----EIPYWSLGPELTRDYDE 131
PRK09669 PRK09669
putative symporter YagG; Provisional
 50-107 6.41e-03

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 39.71  E-value: 6.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024478201  50 GLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGalFGLSLML 107
Cdd:PRK09669   41 GLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPYLLWFAIP--FGVVCLL 96
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 34-660 8.43e-101

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 315.34  E-value: 8.43e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  34 GYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALFGLSLMLNGRDIG 113
Cdd:cd17313    14 GWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAALGLILIPNAADIG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 114 SALSDtvNNHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDRGLNIHALLAGLGGGFGYVIGGIHWDKTSFG 193
Cdd:cd17313    94 LALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 194 KAVGGQLRVIYVFTSIILTITTVLTLISIPERPLGSfsrkkkvmkspslplppspplffeegvnenfasrnsdhlyasft 273
Cdd:cd17313   172 FALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSP-------------------------------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 274 spvsplspltpkygsfvsrdnsltginefassfgtsnidsvlidcftgghssylalpaslprqpvsvsfprvpdgcyqqe 353
Cdd:cd17313       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 354 ngilEQGERSIIPGPDGEALRVGSLDAIKPRssgilkrpqslaipdivtghcpessrrrnvtfsqqvanilldgvkyese 433
Cdd:cd17313   208 ----EAGEHSENPSLGEVLKSLLKLLKIMPR------------------------------------------------- 234

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 434 lngsgetseqplSMRLLCstichmpralrnlcINHFLGWLSFEGMLLFYTDFMGEVVFEGNPKAphnsdeYQKYNAGVTM 513
Cdd:cd17313   235 ------------SLLRLL--------------LVIFFWWIAFFPFELFFTDYMGEEVYHGTSAA------SSHYGAGVRM 282

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 514 GCWGMCIYAFSAAFYSAALEKLEERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFATLCTLPYSLLCDY 593
Cdd:cd17313   283 GAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDY 362

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024478201 594 yqscefagshTEGTRRGMGVDISLLSCQYFLAQILVALAMGPL--TTAVGSASGTMYFASLVSFLGCLF 660
Cdd:cd17313   363 ----------HSESGRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 34-156 1.81e-18

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 88.71  E-value: 1.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  34 GYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALFGLSLMLNGRDIG 113
Cdd:TIGR01301  19 GWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGAALVAFAVILIGFAADIG 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2024478201 114 SALSDTVN--NHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVC 156
Cdd:TIGR01301  99 HLFGDNLDkkTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLT 143
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
34-107 1.32e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 70.32  E-value: 1.32e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024478201  34 GYAMETAYVTPVLLQ-MGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVgaLFGLSLML 107
Cdd:COG2211    25 AFGLLSAYLLYFYTDvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAI--PLALSFVL 97
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 32-226 4.39e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.81  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  32 YSGYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFILVLAVGALFGLSLMLNgrd 111
Cdd:cd06174     9 GLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGRRPVLLLGLLLFALGALLFAFA--- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 112 igsalsdtvnnhkWGIVLTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDRGLNIHALLAGLGGGFGYVIGGIHWDKTS 191
Cdd:cd06174    82 -------------PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG 148

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2024478201 192 FGkavggqLRVIYVFTSIILTITTVLTLISIPERP 226
Cdd:cd06174   149 FG------WRAVFLIAAALALLAAILLLLVVPDPP 177
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 52-163 1.40e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 47.84  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  52 PDQLYGMVWFISPILGFLLQPLLGAWSDRCtsrfGRRRPFILV---LAVGALFGLSLMLNGrdigsalsdtvnnhkwGIV 128
Cdd:COG2270    50 ATALWGYALAIAGLLVALLAPVLGAIADRS----GRKKPFLAFftlLGVLATAALFFVAPG----------------GLW 109

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2024478201 129 LTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDR 163
Cdd:COG2270   110 LGLLLFVLANIGFEGSLVFYNAFLPDIATPEEIGR 144
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 41-161 8.91e-05

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 45.38  E-value: 8.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  41 YVTPVLlqmGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALFGLSLMLNGRDIGSALSDTv 120
Cdd:pfam13347  23 FYTDVL---GLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILLFTPPELGRAPLFI- 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2024478201 121 nnhkWGIVLTVCGVVLMDFSadsaDNPSHAYMMDVCSPMDQ 161
Cdd:pfam13347  99 ----WLLATYILLRIAYTFF----EIPYWSLGPELTRDYDE 131
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 41-106 1.66e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 44.52  E-value: 1.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024478201  41 YVTPVllqMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALFGLSLM 106
Cdd:cd17332    25 FYTDV---LGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPLALLFVLL 87
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 534-661 4.52e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.95  E-value: 4.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 534 KLEERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFATLctLPYSLLcdyyqsceFAGSHTEGTRRGMGv 613
Cdd:cd17473   255 RLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLL--LPTLNS--------WAMSLVPPELRGRA- 323

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2024478201 614 dISLLSCQYFLAQILVALAMGPLTTAVGSASGTMYFASLVSFLGCLFS 661
Cdd:cd17473   324 -MGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
MFS_1 pfam07690
Major Facilitator Superfamily;
34-134 9.36e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.02  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  34 GYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFILVLAVGALFGLSLMLngrdig 113
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLALLLLILAALGLLL------ 284

                          90       100
                  ....*....|....*....|.
gi 2024478201 114 saLSDTVNNHKWGIVLTVCGV 134
Cdd:pfam07690 285 --LSLTLSSLWLLLALLLLGF 303
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 48-112 1.69e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.36  E-value: 1.69e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024478201  48 QMGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFIL--VLAVGALFGLSLMLNGRDI 112
Cdd:cd17369   258 TLGVDRSTVLLAVLIASVVAAITIPLFGWLSD----RVGRRPVYLAgaLLAALFAFPFFWLLDTGST 320
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 459-661 1.76e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.26  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 459 RALRNLCINHFLGWLSFEGMLLFYTDFMGEVVfegnpkapHNSDEYQKYNAGVTMGC--WGMCIYAFSaafysaalekLE 536
Cdd:cd06174   203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG--------GLSVAVAGLLLSLFGLAgaLGSLLLGLL----------SD 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 537 ERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFATLCTLPYSLLCDYYQscefagshtegtRRGMGVDIS 616
Cdd:cd06174   265 RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP------------PEIRGTAFG 332

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2024478201 617 LLSCQYFLAQILVALAMGPLTTAVGSASGTMYFASLVSFLGCLFS 661
Cdd:cd06174   333 LLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 44-158 1.99e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201  44 PVLLQ--MGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFILVLAVGALFGLSLmlngrdigsALSDTVn 121
Cdd:cd17325   223 PLYAAelGGLSPAQIGLLFGAQGLASALSQPPAGKLSD----RIGRKPLILIGLLLSAVALLLL---------PLATSF- 288

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2024478201 122 nhkWGIVLtvcGVVLMDFSADSADNPSHAYMMDVCSP 158
Cdd:cd17325   289 ---WLLLL---LLALLGLGLGLVFPATLALLADIVPP 319
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
538-666 2.09e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.04  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024478201 538 RFSTRTLYFIAYLAFGLGTGLATLSR--NIYIVLSLCTTYGILFATLCTLPYSLL---CDYyqscefaGSHTEGTRRgMG 612
Cdd:COG2211   290 RFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLadvVDY-------DEWKTGRRR-EG 361

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024478201 613 VDISLLSCQYFLAQILVALAMGPLTTAVG-------SASGTMYFASLVSFLGCLFSSLCVI 666
Cdd:COG2211   362 LYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRLLFFLLPAVLLLLAAL 422
PRK09669 PRK09669
putative symporter YagG; Provisional
 50-107 6.41e-03

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 39.71  E-value: 6.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024478201  50 GLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGalFGLSLML 107
Cdd:PRK09669   41 GLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPYLLWFAIP--FGVVCLL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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