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Conserved domains on  [gi|2024484409|ref|XP_040547821|]
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protein TANC2 isoform X11 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1001-1200 9.15e-55

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 193.63  E-value: 9.15e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1001 INSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1080
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1081 MAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1160
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2024484409 1161 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1200
Cdd:COG0666    206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
PHA03095 super family cl33707
ankyrin-like protein; Provisional
 831-1126 4.24e-20

ankyrin-like protein; Provisional


The actual alignment was detected with superfamily member PHA03095:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.86  E-value: 4.24e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  831 RNLYTPNIKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDAASESGLTPLG-YAAAAG 904
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  905 FLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWSMAGQQQ-GVFKKSHAIQQaliaaas 975
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  976 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHW 1055
Cdd:PHA03095   168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024484409 1056 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRA 1126
Cdd:PHA03095   236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRA 308
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1236-1350 5.45e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 5.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1467-1766 8.98e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.07  E-value: 8.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1467 STSPTLSPTH----QNSHYRPSPPH-----TSPAHQGSSYRF----SPPPVGS-QGKEYQSPPPSPLRRGPQYRA---SP 1529
Cdd:pfam05109  429 TTSPTLNTTGfaapNTTTGLPSSTHvptnlTAPASTGPTVSTadvtSPTPAGTtSGASPVTPSPSPRDNGTESKApdmTS 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1530 PADGMSVYRSQSGSPVryqqePSAVSPLPGRPKSPLSKMSQRSFQMPQLPVAV-PQQGLRLQPAKAQI--VRSNQPSSAV 1606
Cdd:pfam05109  509 PTSAVTTPTPNATSPT-----PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATsPTPAVTTPTPNATIptLGKTSPTSAV 583

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1607 HSSTviPTGAYSQVAHSMASKYQAAAGEMGVNQSRLVyqgsiggivgdSRPVQHVQASLSAGaicQHG--GLAKEDLPQR 1684
Cdd:pfam05109  584 TTPT--PNATSPTVGETSPQANTTNHTLGGTSSTPVV-----------TSPPKNATSAVTTG---QHNitSSSTSSMSLR 647

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1685 PSSayrggmrysqtpqIGRSQSASYYPMCHSKLDLERSSLPSGQLGSPDVShlirrPISVNPSEIKPHPPTPRPLLHSQS 1764
Cdd:pfam05109  648 PSS-------------ISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVT-----PASTSTHHVSTSSPAPRPGTTSQA 709


                   ..
gi 2024484409 1765 VG 1766
Cdd:pfam05109  710 SG 711
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1001-1200 9.15e-55

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 193.63  E-value: 9.15e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1001 INSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1080
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1081 MAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1160
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2024484409 1161 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1200
Cdd:COG0666    206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1079-1165 3.77e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.49  E-value: 3.77e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1079 LMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDhaDKNGRTPLDLAAFYGDAEVVQ 1158
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 2024484409 1159 FLVDHGA 1165
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 831-1126 4.24e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.86  E-value: 4.24e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  831 RNLYTPNIKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDAASESGLTPLG-YAAAAG 904
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  905 FLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWSMAGQQQ-GVFKKSHAIQQaliaaas 975
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  976 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHW 1055
Cdd:PHA03095   168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024484409 1056 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRA 1126
Cdd:PHA03095   236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRA 308
PHA03095 PHA03095
ankyrin-like protein; Provisional
 984-1204 7.99e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.09  E-value: 7.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  984 YLLDLPEKDEEEVER-----AQINsFDSLWGETALTAAAGRGK---LDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGH- 1054
Cdd:PHA03095    18 YLLNASNVTVEEVRRllaagADVN-FRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATt 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1055 WQIVDLLLTHGADVNMADKQGRTPLMMAAS--EGHLGTVEFLLAQGASISLMDKEGLTALswACL--------------- 1117
Cdd:PHA03095    97 LDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrlli 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1118 -KG----------------HL-------AVVRALVENGAATDHADKNGRTPLDLAAFYGD--AEVVQFLVDHGAMIEHVD 1171
Cdd:PHA03095   175 dAGadvyavddrfrsllhhHLqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARN 254

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2024484409 1172 YSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQT 1204
Cdd:PHA03095   255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
Ank_2 pfam12796
Ankyrin repeats (3 copies);
871-949 4.17e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 4.17e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024484409  871 GYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKrAKVDHLDkNGQCALVHAALRGHLEVVKFLIQCD 949
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1236-1350 5.45e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 5.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1009-1130 2.61e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 52.32  E-value: 2.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1009 GETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVV--------------PLFSAVRQGHWQIVDLLLTHGADVNMADKQ 1074
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024484409 1075 GRTPLMMAASEGHLGTV----EFLLAQGASISLM------DKEGLTALSWACLKGHLAVVRALVEN 1130
Cdd:cd22192    169 GNTVLHILVLQPNKTFAcqmyDLILSYDKEDDLQpldlvpNNQGLTPFKLAAKEGNIVMFQHLVQK 234
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1467-1766 8.98e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.07  E-value: 8.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1467 STSPTLSPTH----QNSHYRPSPPH-----TSPAHQGSSYRF----SPPPVGS-QGKEYQSPPPSPLRRGPQYRA---SP 1529
Cdd:pfam05109  429 TTSPTLNTTGfaapNTTTGLPSSTHvptnlTAPASTGPTVSTadvtSPTPAGTtSGASPVTPSPSPRDNGTESKApdmTS 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1530 PADGMSVYRSQSGSPVryqqePSAVSPLPGRPKSPLSKMSQRSFQMPQLPVAV-PQQGLRLQPAKAQI--VRSNQPSSAV 1606
Cdd:pfam05109  509 PTSAVTTPTPNATSPT-----PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATsPTPAVTTPTPNATIptLGKTSPTSAV 583

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1607 HSSTviPTGAYSQVAHSMASKYQAAAGEMGVNQSRLVyqgsiggivgdSRPVQHVQASLSAGaicQHG--GLAKEDLPQR 1684
Cdd:pfam05109  584 TTPT--PNATSPTVGETSPQANTTNHTLGGTSSTPVV-----------TSPPKNATSAVTTG---QHNitSSSTSSMSLR 647

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1685 PSSayrggmrysqtpqIGRSQSASYYPMCHSKLDLERSSLPSGQLGSPDVShlirrPISVNPSEIKPHPPTPRPLLHSQS 1764
Cdd:pfam05109  648 PSS-------------ISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVT-----PASTSTHHVSTSSPAPRPGTTSQA 709


                   ..
gi 2024484409 1765 VG 1766
Cdd:pfam05109  710 SG 711
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1483-1640 1.53e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1483 PSPPHTSPAHQGSSyRFSPPPVgSQGKEYQSPPPSPLRRGPQYRASPPAdgmsvyrsQSGSPVRYQQEPSAVSPLPGRPK 1562
Cdd:PHA03247  2871 PAAKPAAPARPPVR-RLARPAV-SRSTESFALPPDQPERPPQPQAPPPP--------QPQPQPPPPPQPQPPPPPPPRPQ 2940

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1563 SPLSKMSQRSFQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSSA---------VHSSTVIPTGAYSQVAHSMASKYQAAAG 1633
Cdd:PHA03247  2941 PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPP 3020


                   ....*..
gi 2024484409 1634 EMGVNQS 1640
Cdd:PHA03247  3021 PVSLKQT 3027
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 991-1168 3.28e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 48.92  E-value: 3.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  991 KDEEEVERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQgaavaqpNRRGVV--PLFSAVRQGHWQIVDLLLTHGADV 1068
Cdd:TIGR00870   35 RDLEEPKKLNINCPDRLGRSALFVAAIENENLELTELLLNL-------SCRGAVgdTLLHAISLEYVDAVEAILLHLLAA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1069 nmADKQGRTPLMMAASeghlgTVEFllaqgasislmdKEGLTALSWACLKGHLAVVRALVENGAA------------TDH 1136
Cdd:TIGR00870  108 --FRKSGPLELANDQY-----TSEF------------TPGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQG 168

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2024484409 1137 AD--KNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1168
Cdd:TIGR00870  169 VDsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1237-1352 5.97e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 5.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1237 DMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYAR 1316
Cdd:TIGR02917  507 RIDIQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALAL 573

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2024484409 1317 ARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLR 1352
Cdd:TIGR02917  574 AQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
TPR_14 pfam13428
Tetratricopeptide repeat;
1311-1353 1.35e-04

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 41.25  E-value: 1.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2024484409 1311 EAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1353
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1140-1168 1.39e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 1.39e-04
                            10        20
                    ....*....|....*....|....*....
gi 2024484409  1140 NGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1168
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 1290-1341 2.13e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 42.47  E-value: 2.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024484409 1290 NDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCP 1341
Cdd:PLN03088    16 DDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDP 67
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1310-1343 5.26e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 5.26e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2024484409  1310 YEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1343
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1001-1200 9.15e-55

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 193.63  E-value: 9.15e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1001 INSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1080
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1081 MAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1160
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2024484409 1161 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1200
Cdd:COG0666    206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1009-1200 1.67e-53

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 189.78  E-value: 1.67e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1009 GETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHL 1088
Cdd:COG0666     87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1089 GTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1168
Cdd:COG0666    167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024484409 1169 HVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1200
Cdd:COG0666    247 AKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
858-1178 2.65e-49

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 177.84  E-value: 2.65e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  858 LNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRG 937
Cdd:COG0666     19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  938 HLEVVKFLIQcdwsmAGqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeeverAQINSFDSlWGETALTAAA 1017
Cdd:COG0666     99 DLEIVKLLLE-----AG--------------------------------------------ADVNARDK-DGETPLHLAA 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1018 GRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQ 1097
Cdd:COG0666    129 YNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1098 GASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRP 1177
Cdd:COG0666    209 GADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288


                   .
gi 2024484409 1178 L 1178
Cdd:COG0666    289 L 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
826-1145 6.44e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 167.82  E-value: 6.44e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  826 ALASLRNLYTPNIKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGF 905
Cdd:COG0666     20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  906 LSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQcdwsmAGqqqgvfkkshaiqqaliaaasmgyteivsyl 985
Cdd:COG0666    100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-----AG------------------------------- 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  986 ldlpekdeeeverAQINSFDSlWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHG 1065
Cdd:COG0666    144 -------------ADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAG 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1066 ADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPL 1145
Cdd:COG0666    210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1079-1165 3.77e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.49  E-value: 3.77e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1079 LMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDhaDKNGRTPLDLAAFYGDAEVVQ 1158
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 2024484409 1159 FLVDHGA 1165
Cdd:pfam12796   79 LLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1046-1132 1.23e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.25  E-value: 1.23e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1046 LFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGAsiSLMDKEGLTALSWACLKGHLAVVR 1125
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 2024484409 1126 ALVENGA 1132
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 831-1126 4.24e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.86  E-value: 4.24e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  831 RNLYTPNIKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDAASESGLTPLG-YAAAAG 904
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  905 FLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWSMAGQQQ-GVFKKSHAIQQaliaaas 975
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  976 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHW 1055
Cdd:PHA03095   168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024484409 1056 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRA 1126
Cdd:PHA03095   236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRA 308
PHA03095 PHA03095
ankyrin-like protein; Provisional
 984-1204 7.99e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 95.09  E-value: 7.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  984 YLLDLPEKDEEEVER-----AQINsFDSLWGETALTAAAGRGK---LDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGH- 1054
Cdd:PHA03095    18 YLLNASNVTVEEVRRllaagADVN-FRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATt 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1055 WQIVDLLLTHGADVNMADKQGRTPLMMAAS--EGHLGTVEFLLAQGASISLMDKEGLTALswACL--------------- 1117
Cdd:PHA03095    97 LDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrlli 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1118 -KG----------------HL-------AVVRALVENGAATDHADKNGRTPLDLAAFYGD--AEVVQFLVDHGAMIEHVD 1171
Cdd:PHA03095   175 dAGadvyavddrfrsllhhHLqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARN 254

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2024484409 1172 YSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQT 1204
Cdd:PHA03095   255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1013-1105 9.05e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.86  E-value: 9.05e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1013 LTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHgADVNMADkQGRTPLMMAASEGHLGTVE 1092
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2024484409 1093 FLLAQGASISLMD 1105
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1010-1231 1.26e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 90.82  E-value: 1.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1010 ETALTAAAGRGKLDVCRLLLEQGAavaQPN---RRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEG 1086
Cdd:PHA02875     3 QVALCDAILFGELDIARRLLDIGI---NPNfeiYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1087 HLGTVEFLLAQGASIS-LMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1165
Cdd:PHA02875    80 DVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024484409 1166 MIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI------GCQTLpsrprgpATWAMATSKPDIMIILLSK 1231
Cdd:PHA02875   160 CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIdyfgknGCVAA-------LCYAIENNKIDIVRLFIKR 224
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 891-1181 2.97e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 86.56  E-value: 2.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  891 ESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQcdwsmagqqQGVfkkshaiqqal 970
Cdd:PHA02874    33 DETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLID---------NGV----------- 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  971 iaaasmgyteiVSYLLDLPEKDEEEVER-----AQINSFDSLwGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVP 1045
Cdd:PHA02874    93 -----------DTSILPIPCIEKDMIKTildcgIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1046 LFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVvr 1125
Cdd:PHA02874   161 IHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-- 238

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024484409 1126 ALVENGAATDHADKNGRTPLDLAAFYG-DAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1181
Cdd:PHA02874   239 ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1021-1200 7.10e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 85.49  E-value: 7.10e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1021 KLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQ-----IVDLLLTHGADVNMADKQGRTPLMMAASE--GHLGTVEF 1093
Cdd:PHA03100    47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEY 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1094 LLAQGASISLMDKEGLTALSWA--CLKGHLAVVRALVENGA----------------ATDHADKNGRTPLDLAAFYGDAE 1155
Cdd:PHA03100   127 LLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVdinaknrvnyllsygvPINIKDVYGFTPLHYAVYNNNPE 206

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2024484409 1156 VVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1200
Cdd:PHA03100   207 FVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1011-1194 1.17e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 85.02  E-value: 1.17e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1011 TALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGAD----------------------- 1067
Cdd:PHA02874    37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildcgid 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1068 VNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDL 1147
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2024484409 1148 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVgCRNTSVVVTLL 1194
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHNRSAIELLI 242
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 907-1140 2.42e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.56  E-value: 2.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  907 SIVVLLCKKRAKVDHLDKNGQCALVHAALRGH-----LEVVKFLIQcdwsmAGQQQGVFKKSHAIQQALIAAASMGYTEI 981
Cdd:PHA03100    49 DVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLE-----YGANVNAPDNNGITPLLYAISKKSNSYSI 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  982 VSYLLDLpekdeeeveRAQINSFDSlWGETALTAAA--GRGKLDVCRLLLEQGAAVAQPNRrgvvplfsavrqghwqiVD 1059
Cdd:PHA03100   124 VEYLLDN---------GANVNIKNS-DGENLLHLYLesNKIDLKILKLLIDKGVDINAKNR-----------------VN 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1060 LLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADK 1139
Cdd:PHA03100   177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256


                   .
gi 2024484409 1140 N 1140
Cdd:PHA03100   257 T 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 838-1200 3.01e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 84.73  E-value: 3.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  838 IKVSRLLILGGANVNYRtEVLNNAPILCVQSHlGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRA 917
Cdd:PHA02876   158 LLIAEMLLEGGADVNAK-DIYCITPIHYAAER-GNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  918 KVDHLDkngqCALVHAALRGHLEVVKFLIQCDWSMagQQQGVFKKSHAIQQALIAAASmgytEIVSYLLdlpekdeeevE 997
Cdd:PHA02876   236 NINKND----LSLLKAIRNEDLETSLLLYDAGFSV--NSIDDCKNTPLHHASQAPSLS----RLVPKLL----------E 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  998 RAQINSFDSLWGETALTAAAGRG-KLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQ-IVDLLLTHGADVNMADKQG 1075
Cdd:PHA02876   296 RGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCD 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1076 RTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWA-CLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYG-D 1153
Cdd:PHA02876   376 KTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcK 455

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 2024484409 1154 AEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRntSVVVTLLKKGAKI 1200
Cdd:PHA02876   456 LDVIEMLLDNGADVNAINIQNQYPLLIALEYH--GIVNILLHYGAEL 500
Ank_2 pfam12796
Ankyrin repeats (3 copies);
871-949 4.17e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 4.17e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024484409  871 GYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKrAKVDHLDkNGQCALVHAALRGHLEVVKFLIQCD 949
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
Ank_2 pfam12796
Ankyrin repeats (3 copies);
977-1072 1.97e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 1.97e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  977 GYTEIVSYLLDlpekdeeevERAQINSFDSlWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNrrGVVPLFSAVRQGHWQ 1056
Cdd:pfam12796    8 GNLELVKLLLE---------NGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 2024484409 1057 IVDLLLTHGADVNMAD 1072
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1043-1200 2.44e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 74.61  E-value: 2.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1043 VVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLM------------------ 1104
Cdd:PHA02874    36 TTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILpipciekdmiktildcgi 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1105 -----DKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLD 1179
Cdd:PHA02874   116 dvnikDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                          170       180
                   ....*....|....*....|.
gi 2024484409 1180 RAVGCRNTSVVVTLLKKGAKI 1200
Cdd:PHA02874   196 NAAEYGDYACIKLLIDHGNHI 216
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1236-1350 5.45e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 5.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 977-1198 8.08e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 8.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  977 GYTEIVSYLLDLpekdeeeveraQIN-SFDSLWGETALTAAAGRGKLDVCRLLLEQGAA--VAQPNRRGvvPLFSAVRQG 1053
Cdd:PHA02875    13 GELDIARRLLDI-----------GINpNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIpdVKYPDIES--ELHDAVEEG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1054 HWQIVDLLLTHGADVN-MADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGA 1132
Cdd:PHA02875    80 DVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1133 ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAmieHVDYSGMRP----LDRAVGCRNTSVVVTLLKKGA 1198
Cdd:PHA02875   160 CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA---NIDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGA 226
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1236-1350 3.36e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 3.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG0457     49 GLAYLRLGRYEEALADYEQALELDPDD-------------AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG0457    116 LGLALLELGRYDEAIEAYERALELDPDDADALYNL 150
Ank_2 pfam12796
Ankyrin repeats (3 copies);
897-1033 6.37e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 6.37e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  897 LGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIqcdwsmagqqqgvfkkshaiqqaliaaasm 976
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL------------------------------ 50

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024484409  977 gyteivsylldlpekdeeevERAQINSFDSlwGETALTAAAGRGKLDVCRLLLEQGA 1033
Cdd:pfam12796   51 --------------------EHADVNLKDN--GRTALHYAARSGHLEIVKLLLEKGA 85
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1022-1171 6.96e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.69  E-value: 6.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1022 LDVCRLLLEQGAAVAQPNRRGVVPLFSAV--RQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGT--------- 1090
Cdd:PHA03100    86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidk 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1091 ---------VEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1161
Cdd:PHA03100   166 gvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245

                          170
                   ....*....|
gi 2024484409 1162 DHGAMIEHVD 1171
Cdd:PHA03100   246 NNGPSIKTII 255
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1056-1182 8.93e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 8.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1056 QIVDLLLTHGADVNMADK-QGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAAT 1134
Cdd:PHA02878   148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1135 DHADKNGRTPLDLAAFY---------------------------------GDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1181
Cdd:PHA02878   228 DARDKCGNTPLHISVGYckdydilklllehgvdvnaksyilgltalhssiKSERKLKLLLEYGADINSLNSYKLTPLSSA 307


                   .
gi 2024484409 1182 V 1182
Cdd:PHA02878   308 V 308
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1022-1205 9.28e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 70.28  E-value: 9.28e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1022 LDVCRLLLEQGAAVAQPNRRGvvPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASI 1101
Cdd:PLN03192   507 LNVGDLLGDNGGEHDDPNMAS--NLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNV 584

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1102 SLMDKEGLTALSWACLKGHLAVVRALVENGAATD-HAdknGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1180
Cdd:PLN03192   585 HIRDANGNTALWNAISAKHHKIFRILYHFASISDpHA---AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQV 661

                          170       180
                   ....*....|....*....|....*
gi 2024484409 1181 AVGCRNTSVVVTLLKKGAKIGCQTL 1205
Cdd:PLN03192   662 AMAEDHVDMVRLLIMNGADVDKANT 686
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1236-1343 1.46e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.06  E-value: 1.46e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG4783     45 GEILLQLGDLDEAIVLLHEALELDPDE-------------PEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLR 111

                           90       100
                   ....*....|....*....|....*...
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNN 1343
Cdd:COG4783    112 LARAYRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1236-1352 1.81e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.25  E-value: 1.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG3914    119 GNLLLALGRLEEALAALRRALALNPDF-------------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNN 185

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLR 1352
Cdd:COG3914    186 LGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1239-1345 1.84e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 62.11  E-value: 1.84e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1239 FYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFaTKALELKPKSYEAYYARAR 1318
Cdd:COG3063      2 YLKLGDLEEAEEYYEKALELDPDNA-------------DALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAE 67

                           90       100
                   ....*....|....*....|....*..
gi 2024484409 1319 AKRSSRQFAAALEDLNEAIKLCPNNRE 1345
Cdd:COG3063     68 LLLELGDYDEALAYLERALELDPSALR 94
Ank_4 pfam13637
Ankyrin repeats (many copies);
1108-1161 1.97e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 60.75  E-value: 1.97e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024484409 1108 GLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1161
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1229-1350 3.20e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 62.90  E-value: 3.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1229 LSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPK 1308
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELDPDN-------------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2024484409 1309 SYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG4783     71 EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRL 112
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1239-1350 5.68e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 67.71  E-value: 5.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1239 FYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARAR 1318
Cdd:COG3914     88 LQALGRYEEALALYRRALALNPDN-------------AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2024484409 1319 AKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG3914    155 ALRRLGRLEEAIAALRRALELDPDNAEALNNL 186
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1232-1353 1.21e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.37  E-value: 1.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1232 LMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1311
Cdd:COG2956     79 LLELAQDYLKAGLLDRAEELLEKLLELDPDD-------------AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH 145

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2024484409 1312 AYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1353
Cdd:COG2956    146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 839-1171 2.45e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.98  E-value: 2.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  839 KVSRLLILGGANvnyrTEVLnnaPILCVQShlgytEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRAK 918
Cdd:PHA02874    82 DIIKLLIDNGVD----TSIL---PIPCIEK-----DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  919 VDHLDKNGqCALVHAALRGhlevvkfliqcdwsmagqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeever 998
Cdd:PHA02874   150 VNIEDDNG-CYPIHIAIKH------------------------------------------------------------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  999 aqiNSFdslwgetaltaaagrgklDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTP 1078
Cdd:PHA02874   168 ---NFF------------------DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTP 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1079 LMMAASegHLGTVEFLLAQGASISLMDKEGLTALSWA----CLKGhlaVVRALVENGAATDHADKNGRTPLDLAAFY-GD 1153
Cdd:PHA02874   227 LHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAinppCDID---IIDILLYHKADISIKDNKGENPIDTAFKYiNK 301

                          330
                   ....*....|....*...
gi 2024484409 1154 AEVVQFLVDHGAMIEHVD 1171
Cdd:PHA02874   302 DPVIKDIIANAVLIKEAD 319
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1021-1200 2.51e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.47  E-value: 2.51e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1021 KLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVE-------- 1092
Cdd:PHA02876   157 ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKaiidnrsn 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1093 ---------------------FLLAQGASISLMDKEGLTALSWACLKGHLA-VVRALVENGAATDHADKNGRTPLDLAAF 1150
Cdd:PHA02876   237 inkndlsllkairnedletslLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAK 316

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024484409 1151 YG-DAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGC-RNTSVVVTLLKKGAKI 1200
Cdd:PHA02876   317 NGyDTENIRTLIMLGADVNAADRLYITPLHQASTLdRNKDIVITLLELGANV 368
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1050-1205 2.55e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.47  E-value: 2.55e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1050 VRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVE 1129
Cdd:PHA02876   153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024484409 1130 NGAatdHADKNGRTPLDlAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS-VVVTLLKKGAKIGCQTL 1205
Cdd:PHA02876   233 NRS---NINKNDLSLLK-AIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNI 305
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1247-1350 3.39e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.63  E-value: 3.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1247 EAAQRYQYALKKFPREGFGedlktfrelkvslLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQF 1326
Cdd:COG4235      1 EAIARLRQALAANPNDAEG-------------WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT 67

                           90       100
                   ....*....|....*....|....
gi 2024484409 1327 AAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG4235     68 EEAEELLERALALDPDNPEALYLL 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 999-1163 3.54e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.52  E-value: 3.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  999 AQINSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTP 1078
Cdd:PHA02878   158 ADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1079 LMMAASE-GHLGTVEFLLAQGASISLMDK-EGLTALswaclkgHLA-----VVRALVENGAATDHADKNGRTPLDLAAF- 1150
Cdd:PHA02878   238 LHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTAL-------HSSikserKLKLLLEYGADINSLNSYKLTPLSSAVKq 310

                          170
                   ....*....|...
gi 2024484409 1151 YGDAEVVQFLVDH 1163
Cdd:PHA02878   311 YLCINIGRILISN 323
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1236-1349 4.44e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.25  E-value: 4.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG4235     24 GRAYLRLGRYDEALAAYEKALRLDPDN-------------ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRL 1349
Cdd:COG4235     91 LGLAAFQQGDYAEAIAAWQKLLALLPADAPARLL 124
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1021-1173 4.55e-10

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 64.47  E-value: 4.55e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1021 KLDVCRLLLEQGAAVAQPNRRGVVPLFSAVR-----QGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLL 1095
Cdd:PHA02798    50 STDIVKLFINLGANVNGLDNEYSTPLCTILSnikdyKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILL 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1096 ---AQGASISLMDKEGLTALSWACLKGH---LAVVRALVENGAATD-HADKNGRTPLDLAAFYG----DAEVVQFLVDHG 1164
Cdd:PHA02798   130 fmiENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINtHNNKEKYDTLHCYFKYNidriDADILKLFVDNG 209


                   ....*....
gi 2024484409 1165 AMIEHVDYS 1173
Cdd:PHA02798   210 FIINKENKS 218
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1081-1163 4.89e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 64.53  E-value: 4.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1081 MAASEGHLGtVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1160
Cdd:PTZ00322    89 LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                   ...
gi 2024484409 1161 VDH 1163
Cdd:PTZ00322   168 SRH 170
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1247-1353 8.40e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.59  E-value: 8.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1247 EAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQF 1326
Cdd:COG5010     25 EKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDK 104

                           90       100
                   ....*....|....*....|....*..
gi 2024484409 1327 AAALEDLNEAIKLCPNNREIQRLLLRV 1353
Cdd:COG5010    105 DEAKEYYEKALALSPDNPNAYSNLAAL 131
Ank_4 pfam13637
Ankyrin repeats (many copies);
1045-1095 9.75e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.74  E-value: 9.75e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024484409 1045 PLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLL 1095
Cdd:pfam13637    4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1279-1343 1.22e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 1.22e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024484409 1279 LLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1343
Cdd:COG0457     11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 835-1074 1.27e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.76  E-value: 1.27e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  835 TPNIKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGF--LSIVVLL 912
Cdd:PHA03100    83 TDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLL 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  913 CKKRAKVDHLDKngqcalvhaalrghlevVKFLIqcdwsmagqqqgvfkkshaiqqaliaaasmgyteivSYLLDLPEKD 992
Cdd:PHA03100   163 IDKGVDINAKNR-----------------VNYLL------------------------------------SYGVPINIKD 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  993 EeeveraqinsfdslWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMAD 1072
Cdd:PHA03100   190 V--------------YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255


                   ..
gi 2024484409 1073 KQ 1074
Cdd:PHA03100   256 ET 257
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1058-1178 1.74e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 62.99  E-value: 1.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1058 VDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALVenGAATDHA 1137
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS--RHSQCHF 175

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2024484409 1138 DKNGRTPLDlaAFYGdaeVVQFLVDHGAMIEHVDYSGM-RPL 1178
Cdd:PTZ00322   176 ELGANAKPD--SFTG---KPPSLEDSPISSHHPDFSAVpQPM 212
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1238-1341 2.61e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.05  E-value: 2.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1238 MFYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARA 1317
Cdd:COG5010     63 LYNKLGDFEESLALLEQALQLDPNNP-------------ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLA 129

                           90       100
                   ....*....|....*....|....
gi 2024484409 1318 RAKRSSRQFAAALEDLNEAIKLCP 1341
Cdd:COG5010    130 ALLLSLGQDDEAKAALQRALGTSP 153
Ank_4 pfam13637
Ankyrin repeats (many copies);
1075-1128 2.64e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 2.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024484409 1075 GRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVVRALV 1128
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1236-1404 6.24e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 6.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG0457     83 GLALQALGRYEEALEDYDKALELDPDD-------------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQVQQQQQQQQQQPPPLPAEPEPEAQHEELYSVQDIFE 1395
Cdd:COG0457    150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229


                   ....*....
gi 2024484409 1396 EEYLEQDVE 1404
Cdd:COG0457    230 LLALRLAAL 238
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1232-1345 9.52e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.00  E-value: 9.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1232 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1311
Cdd:COG4785     76 YYERGVAYDSLGDYDLAIADFDQALELDPD-------------LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAY 142

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024484409 1312 AYYARARAKRSSRQFAAALEDLNEAIKLCPNNRE 1345
Cdd:COG4785    143 AYLNRGIALYYLGRYELAIADLEKALELDPNDPE 176
Ank_4 pfam13637
Ankyrin repeats (many copies);
1141-1194 3.37e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 3.37e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024484409 1141 GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1194
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1205-1343 3.61e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 3.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1205 LPSRPRGPATWAMATSKPDIMiillSKLMEEGDMFYKkgkVKEAAQRYQYALKKFPREGFGEDLKTFRELK----VSLLL 1280
Cdd:COG4785      5 ALALLLALALAAAAASKAAIL----LAALLFAAVLAL---AIALADLALALAAAALAAAALAAERIDRALAlpdlAQLYY 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024484409 1281 NLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1343
Cdd:COG4785     78 ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDY 140
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1236-1350 3.83e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 3.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG2956     49 GNLYRRRGEYDRAIRIHQKLLERDPD-------------RAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRL 115

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG2956    116 LAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCEL 150
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1224-1353 4.68e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 4.68e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1224 IMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKAL 1303
Cdd:COG2956      3 LPVAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPET-------------VEAHLALGNLYRRRGEYDRAIRIHQKLL 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1304 ELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1353
Cdd:COG2956     70 ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1236-1321 5.43e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 52.69  E-value: 5.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLktfrelkvslLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG1729     37 GEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDA----------LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEA 106


                   ....*.
gi 2024484409 1316 RARAKR 1321
Cdd:COG1729    107 RARLAR 112
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1275-1350 7.42e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.27  E-value: 7.42e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024484409 1275 KVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG4783      3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL 78
Ank_5 pfam13857
Ankyrin repeats (many copies);
1061-1112 8.41e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.42  E-value: 8.41e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024484409 1061 LLTHG-ADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTAL 1112
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 837-1072 1.67e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.41  E-value: 1.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  837 NIKVSRLLilgGANVNYRTEVLNNAPILCVQShLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKR 916
Cdd:PLN03192   506 DLNVGDLL---GDNGGEHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA 581

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  917 AKVDHLDKNGQCALVHAALRGHLEVVKFLIQCdwsmagqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeev 996
Cdd:PLN03192   582 CNVHIRDANGNTALWNAISAKHHKIFRILYHF------------------------------------------------ 613

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024484409  997 erAQINsfDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMAD 1072
Cdd:PLN03192   614 --ASIS--DPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
Ank_4 pfam13637
Ankyrin repeats (many copies);
893-946 1.84e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 1.84e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024484409  893 GLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 946
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
842-923 3.00e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 3.00e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  842 RLLILGGANVNYRTEVLNNAPILCVQShlGYTEMVALLLEFgANVDAaSESGLTPLGYAAAAGFLSIVVLLCKKRAKVDH 921
Cdd:pfam12796   14 KLLLENGADANLQDKNGRTALHLAAKN--GHLEIVKLLLEH-ADVNL-KDNGRTALHYAARSGHLEIVKLLLEKGADINV 89


                   ..
gi 2024484409  922 LD 923
Cdd:pfam12796   90 KD 91
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1285-1353 4.43e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 4.43e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024484409 1285 CRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEdLNEAIKLCPNNREIQRLLLRV 1353
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAEL 68
Ank_4 pfam13637
Ankyrin repeats (many copies);
862-912 4.53e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 4.53e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024484409  862 PILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLL 912
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1232-1349 9.58e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 9.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1232 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1311
Cdd:COG2956    147 YCELAELYLEQGDYDEAIEALEKALKLDPD-------------CARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2024484409 1312 AYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRL 1349
Cdd:COG2956    214 ALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251
Ank_5 pfam13857
Ankyrin repeats (many copies);
1105-1148 1.00e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.34  E-value: 1.00e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2024484409 1105 DKEGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLA 1148
Cdd:pfam13857   13 DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1009-1130 2.61e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 52.32  E-value: 2.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1009 GETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVV--------------PLFSAVRQGHWQIVDLLLTHGADVNMADKQ 1074
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024484409 1075 GRTPLMMAASEGHLGTV----EFLLAQGASISLM------DKEGLTALSWACLKGHLAVVRALVEN 1130
Cdd:cd22192    169 GNTVLHILVLQPNKTFAcqmyDLILSYDKEDDLQpldlvpNNQGLTPFKLAAKEGNIVMFQHLVQK 234
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1239-1348 2.61e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 48.06  E-value: 2.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1239 FYKKGKVKEAAQRYQYALKKFPREgfgedlktfrELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSY---EAYYA 1315
Cdd:COG1729      3 LLKAGDYDEAIAAFKAFLKRYPNS----------PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLK 72

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQR 1348
Cdd:COG1729     73 LGLSYLELGDYDKARATLEELIKKYPDSEAAKE 105
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1044-1200 2.66e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.19  E-value: 2.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1044 VPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISL-------------------- 1103
Cdd:PHA02878    39 IPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVfytlvaikdafnnrnveifk 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1104 ------MDKEGLTALSWACLKGH-----LAVVRALVENGAATDHADKN-GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVD 1171
Cdd:PHA02878   119 iiltnrYKNIQTIDLVYIDKKSKddiieAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPD 198

                          170       180
                   ....*....|....*....|....*....
gi 2024484409 1172 YSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1200
Cdd:PHA02878   199 KTNNSPLHHAVKHYNKPIVHILLENGAST 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 835-1068 6.59e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 6.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  835 TPNIkvsRLLILGGANVNyRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCK 914
Cdd:PHA02876   321 TENI---RTLIMLGADVN-AADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLD 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  915 KRAKVDHLDKNGQCALvHAALRGhlevvkfliqcdwsmagqqqgvfkkshaiqqaliaaaSMGYTEiVSYLLDlpekdee 994
Cdd:PHA02876   397 YGADIEALSQKIGTAL-HFALCG-------------------------------------TNPYMS-VKTLID------- 430

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024484409  995 evERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVrqGHWQIVDLLLTHGADV 1068
Cdd:PHA02876   431 --RGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAEL 500
Ank_5 pfam13857
Ankyrin repeats (many copies);
1028-1082 7.73e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 7.73e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024484409 1028 LLEQG-AAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMA 1082
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1026-1095 8.66e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.67  E-value: 8.66e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024484409 1026 RLLLEQGAavaQPNRR---GVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVEFLL 1095
Cdd:PTZ00322    99 RILLTGGA---DPNCRdydGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1467-1766 8.98e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.07  E-value: 8.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1467 STSPTLSPTH----QNSHYRPSPPH-----TSPAHQGSSYRF----SPPPVGS-QGKEYQSPPPSPLRRGPQYRA---SP 1529
Cdd:pfam05109  429 TTSPTLNTTGfaapNTTTGLPSSTHvptnlTAPASTGPTVSTadvtSPTPAGTtSGASPVTPSPSPRDNGTESKApdmTS 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1530 PADGMSVYRSQSGSPVryqqePSAVSPLPGRPKSPLSKMSQRSFQMPQLPVAV-PQQGLRLQPAKAQI--VRSNQPSSAV 1606
Cdd:pfam05109  509 PTSAVTTPTPNATSPT-----PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATsPTPAVTTPTPNATIptLGKTSPTSAV 583

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1607 HSSTviPTGAYSQVAHSMASKYQAAAGEMGVNQSRLVyqgsiggivgdSRPVQHVQASLSAGaicQHG--GLAKEDLPQR 1684
Cdd:pfam05109  584 TTPT--PNATSPTVGETSPQANTTNHTLGGTSSTPVV-----------TSPPKNATSAVTTG---QHNitSSSTSSMSLR 647

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1685 PSSayrggmrysqtpqIGRSQSASYYPMCHSKLDLERSSLPSGQLGSPDVShlirrPISVNPSEIKPHPPTPRPLLHSQS 1764
Cdd:pfam05109  648 PSS-------------ISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVT-----PASTSTHHVSTSSPAPRPGTTSQA 709


                   ..
gi 2024484409 1765 VG 1766
Cdd:pfam05109  710 SG 711
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1483-1640 1.53e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1483 PSPPHTSPAHQGSSyRFSPPPVgSQGKEYQSPPPSPLRRGPQYRASPPAdgmsvyrsQSGSPVRYQQEPSAVSPLPGRPK 1562
Cdd:PHA03247  2871 PAAKPAAPARPPVR-RLARPAV-SRSTESFALPPDQPERPPQPQAPPPP--------QPQPQPPPPPQPQPPPPPPPRPQ 2940

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1563 SPLSKMSQRSFQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSSA---------VHSSTVIPTGAYSQVAHSMASKYQAAAG 1633
Cdd:PHA03247  2941 PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPP 3020


                   ....*..
gi 2024484409 1634 EMGVNQS 1640
Cdd:PHA03247  3021 PVSLKQT 3027
PHA02946 PHA02946
ankyin-like protein; Provisional
 1028-1178 2.31e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 49.28  E-value: 2.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1028 LLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGRTPL--MMAASEGHLGTVEFLLAQGASI-SLM 1104
Cdd:PHA02946    58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKInNSV 137

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024484409 1105 DKEGLTALsWACLKGHLAVVRALVENGAATDHADKNGRTPL--DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1178
Cdd:PHA02946   138 DEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1455-1634 2.35e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.77  E-value: 2.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1455 SSVGSPTRQGYQSTSPtlsPTHQNSHYRPSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSPPPSPLRRGPQYRASPPAdgm 1534
Cdd:pfam03154  156 SDSDSSAQQQILQTQP---PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT--- 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1535 svyRSQSGSPVRYQQEPSAVSPLPGRPK-SPLSKMSQRSFQMPQLPVAVPQQGLRLQ--PAKAQIVRSNQP--SSAVHSS 1609
Cdd:pfam03154  230 ---LIQQTPTLHPQRLPSPHPPLQPMTQpPPPSQVSPQPLPQPSLHGQMPPMPHSLQtgPSHMQHPVPPQPfpLTPQSSQ 306

                          170       180
                   ....*....|....*....|....*
gi 2024484409 1610 TVIPTGAYSQVAHSMASKYQAAAGE 1634
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTPPSQ 331
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 991-1168 3.28e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 48.92  E-value: 3.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  991 KDEEEVERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQgaavaqpNRRGVV--PLFSAVRQGHWQIVDLLLTHGADV 1068
Cdd:TIGR00870   35 RDLEEPKKLNINCPDRLGRSALFVAAIENENLELTELLLNL-------SCRGAVgdTLLHAISLEYVDAVEAILLHLLAA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1069 nmADKQGRTPLMMAASeghlgTVEFllaqgasislmdKEGLTALSWACLKGHLAVVRALVENGAA------------TDH 1136
Cdd:TIGR00870  108 --FRKSGPLELANDQY-----TSEF------------TPGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQG 168

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2024484409 1137 AD--KNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1168
Cdd:TIGR00870  169 VDsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1075-1167 5.32e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 48.34  E-value: 5.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1075 GRTPLMMAASEGHLGTVE--FLLAQGASISLMDKE------------GLTALSWACLKGHLAVVRALVENGAATdHADKN 1140
Cdd:cd21882     26 GKTCLHKAALNLNDGVNEaiMLLLEAAPDSGNPKElvnapctdefyqGQTALHIAIENRNLNLVRLLVENGADV-SARAT 104

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2024484409 1141 GRT--------------PLDLAAFYGDAEVVQFLVDHGAMI 1167
Cdd:cd21882    105 GRFfrkspgnlfyfgelPLSLAACTNQEEIVRLLLENGAQP 145
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1237-1352 5.97e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 5.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1237 DMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYAR 1316
Cdd:TIGR02917  507 RIDIQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALAL 573

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2024484409 1317 ARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLR 1352
Cdd:TIGR02917  574 AQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1074-1106 6.43e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.51  E-value: 6.43e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024484409 1074 QGRTPLMMAA-SEGHLGTVEFLLAQGASISLMDK 1106
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1304-1352 1.14e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 1.14e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024484409 1304 ELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCP------NNREIQRLLLR 1352
Cdd:COG4785     67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPdlaeayNNRGLAYLLLG 121
TPR_14 pfam13428
Tetratricopeptide repeat;
1311-1353 1.35e-04

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 41.25  E-value: 1.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2024484409 1311 EAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1353
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1140-1168 1.39e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 1.39e-04
                            10        20
                    ....*....|....*....|....*....
gi 2024484409  1140 NGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1168
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 1273-1353 2.03e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 45.67  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1273 ELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEA-YYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLL 1351
Cdd:COG3071     47 EAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAELAvLLTRAELLLDQGQAEQALATLEALRAGAPRHPQVLRLLL 126


                   ..
gi 2024484409 1352 RV 1353
Cdd:COG3071    127 QA 128
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1140-1171 2.22e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 2.22e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2024484409 1140 NGRTPLDLAA-FYGDAEVVQFLVDHGAMIEHVD 1171
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1124-1194 2.43e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 2.43e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024484409 1124 VRALVENGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGcRNTSVVVTLL 1194
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEE-NGFREVVQLL 167
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1303-1350 3.09e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 3.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2024484409 1303 LELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL 48
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1009-1161 5.34e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.07  E-value: 5.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1009 GETALTAAAGRGKLDVCRLLLEQGAAV-AQPN-------------RRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQ 1074
Cdd:TIGR00870  128 GITALHLAAHRQNYEIVKLLLERGASVpARACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1075 GRTPLMMAASEGhlgtvEFllaqgasislmdKEGLTALSWAC---LKGHLAVVRALVENGAATDHadkNGRTPLDLAAFY 1151
Cdd:TIGR00870  208 GNTLLHLLVMEN-----EF------------KAEYEELSCQMynfALSLLDKLRDSKELEVILNH---QGLTPLKLAAKE 267

                          170
                   ....*....|
gi 2024484409 1152 GDAEVVQFLV 1161
Cdd:TIGR00870  268 GRIVLFRLKL 277
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1074-1103 6.01e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 6.01e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2024484409  1074 QGRTPLMMAASEGHLGTVEFLLAQGASISL 1103
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 842-926 6.02e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 6.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  842 RLLILGGANVNYRTevLNNAPILCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRAKVDH 921
Cdd:PTZ00322    99 RILLTGGADPNCRD--YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176


                   ....*
gi 2024484409  922 LDKNG 926
Cdd:PTZ00322   177 LGANA 181
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 1483-1587 6.56e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 6.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1483 PSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSP-PPSPLRRGPQYRASPPADGMSVYRSQSGSPVRYQ-QEPSAVSPLPGR 1560
Cdd:PRK10263   740 PHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPvAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQpQQPVAPQPQYQQ 819

                           90       100
                   ....*....|....*....|....*...
gi 2024484409 1561 PKSPLSkmSQRSFQMPQLPVA-VPQQGL 1587
Cdd:PRK10263   820 PQQPVA--PQPQYQQPQQPVApQPQDTL 845
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 836-900 7.04e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 7.04e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024484409  836 PNIKVSRLLILGGANVNYrTEVLNNAPILCVQSHLGyTEMVALLLEFGANVDAASESGLTPLGYA 900
Cdd:PHA02878   179 KDQRLTELLLSYGANVNI-PDKTNNSPLHHAVKHYN-KPIVHILLENGASTDARDKCGNTPLHIS 241
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1236-1351 8.06e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 8.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:COG3914    153 GEALRRLGRLEEAIAALRRALELDPDN-------------AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN 219

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLL 1351
Cdd:COG3914    220 LLFALRQACDWEVYDRFEELLAALARGPSELSPFAL 255
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1287-1353 8.34e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.21  E-value: 8.34e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024484409 1287 RKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1353
Cdd:COG3914     89 QALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEA 155
Ank_5 pfam13857
Ankyrin repeats (many copies);
1127-1181 8.48e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 8.48e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024484409 1127 LVENG-AATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1181
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1236-1353 1.13e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1315
Cdd:TIGR02917  132 GLAYLGLGQLELAQKSYEQALAIDPRSL-------------YAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLL 198

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2024484409 1316 RARAKRSSRQFAAALEDLNEAIKLCPNNreIQRLLLRV 1353
Cdd:TIGR02917  199 KGDLLLSLGNIELALAAYRKAIALRPNN--IAVLLALA 234
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1009-1196 1.16e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1009 GETALTAAAGRGKLDVCRLLLEqgAA---VAQPNR----RGVVPLFSAVRQGHWQIVDLLLTHGADVNMAdkqgRTplmm 1081
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLME--AApelVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSP----RA---- 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1082 aaseghLGTVeFLLAQGASISLmdkeGLTALSWACLKGHLAVVRALVENGAATDHADKNGRTPLDLAAFYGDA----EVV 1157
Cdd:cd22192    121 ------TGTF-FRPGPKNLIYY----GEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKtfacQMY 189

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2024484409 1158 QFLV-----DHGAMIEHV-DYSGMRPLDRAVGCRNTSVVVTLLKK 1196
Cdd:cd22192    190 DLILsydkeDDLQPLDLVpNNQGLTPFKLAAKEGNIVMFQHLVQK 234
TPR_1 pfam00515
Tetratricopeptide repeat;
1310-1343 1.20e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.17  E-value: 1.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024484409 1310 YEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1343
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 1458-1564 1.21e-03

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 41.56  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1458 GSPTRQGYQStsPTLSPTHQNSHYRPSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSPPPSPLRRGPQYRASPPAdgmsvy 1537
Cdd:pfam15240   75 QPPPQGGKQK--PQGPPPQGGPRPPPGKPQGPPPQGGNQQQGPPPPGKPQGPPPQGGGPPPQGGNQQGPPPPPP------ 146

                           90       100
                   ....*....|....*....|....*..
gi 2024484409 1538 RSQSGSPVRyqqepsavSPLPGRPKSP 1564
Cdd:pfam15240  147 GNPQGPPQR--------PPQPGNPQGP 165
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1460-1814 1.59e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1460 PTRQGYQSTSPTLSPTHQNSHYRPSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSPPPSPlrrGPQYRASPPADGMSVYRS 1539
Cdd:PHA03247  2648 PPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPP---TPEPAPHALVSATPLPPG 2724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1540 QSGSPVRYQQEPSAVSPlPGRPKSPLSKMSQRSFQMPQLPVAVPQQGLRLQPAKAQIVRSNQP--SSAVHSSTVIPTgAY 1617
Cdd:PHA03247  2725 PAAARQASPALPAAPAP-PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPavASLSESRESLPS-PW 2802

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1618 SQVAHSMASKYQAAAGEMGVNQSRLVYQGSIGGIVGDSRPVQHVQASLSAGAICQHGGLAKEDLPQRPSSAYRGGMRYSQ 1697
Cdd:PHA03247  2803 DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPP 2882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1698 TPQIGRSQ-SASYYPMCHSKLDLERSSLPSGQLGSPDVSHLIRRPISVNPSEIKPHP-----PTPRPLLHSQSVGLRFSP 1771
Cdd:PHA03247  2883 VRRLARPAvSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPqpplaPTTDPAGAGEPSGAVPQP 2962

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 2024484409 1772 SSNSISSTSNLTPNFRPSASIQQMEIPLKPAYDRACDELSPVS 1814
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVS 3005
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 977-1161 1.63e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 43.59  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  977 GYTEIVSYLLDLPEKDEEEVEraqinsfdslwgeTALTAAAGRGKLDvcRLLleqGAAVAQPNRRGVVPLFSAVRQGHWQ 1056
Cdd:cd22194     94 GKTCLMKALLNINENTKEIVR-------------ILLAFAEENGILD--RFI---NAEYTEEAYEGQTALNIAIERRQGD 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1057 IVDLLLTHGADVNMADKQ--------------GRTPLMMAASEGHLGTVEFLLAQGAS-ISLMDKEG---LTALSWAC-- 1116
Cdd:cd22194    156 IVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTdITSQDSRGntvLHALVTVAed 235

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024484409 1117 LKGHLAVVRALVENgAATDHADKN--------GRTPLDLAAFYGDAEVVQFLV 1161
Cdd:cd22194    236 SKTQNDFVKRMYDM-ILLKSENKNletirnneGLTPLQLAAKMGKAEILKYIL 287
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1140-1165 1.90e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 1.90e-03
                           10        20
                   ....*....|....*....|....*.
gi 2024484409 1140 NGRTPLDLAAFYGDAEVVQFLVDHGA 1165
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGA 26
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 1290-1341 2.13e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 42.47  E-value: 2.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024484409 1290 NDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCP 1341
Cdd:PLN03088    16 DDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDP 67
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1439-1621 2.27e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 2.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1439 SGSPLGSH----QVFDFRSNSSvgsptrQGYQSTSPTLSPTHQNSHYRPSPPHTSPAHQGSSYRFSPPPVGSQGKEYQSP 1514
Cdd:pfam03154  284 TGPSHMQHpvppQPFPLTPQSS------QSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1515 PPS---PLRRGPQYRASPPadgmsvyrsQSGSPVRYQQePSAVSPLPG-RPKSPLSKMSQRSFQMPqlPVAVPQQGLRLQ 1590
Cdd:pfam03154  358 PPTtpiPQLPNPQSHKHPP---------HLSGPSPFQM-NSNLPPPPAlKPLSSLSTHHPPSAHPP--PLQLMPQSQQLP 425

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024484409 1591 PAKAQ-IVRSNQPSSAVHSSTVIPTGAYSQVA 1621
Cdd:pfam03154  426 PPPAQpPVLTQSQSLPPPAASHPPTSGLHQVP 457
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 1311-1342 2.41e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 37.12  E-value: 2.41e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024484409 1311 EAYYARARAKRSSRQFAAALEDLNEAIKLCPN 1342
Cdd:pfam07719    2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1045-1073 2.56e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.56e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024484409 1045 PLFSAV-RQGHWQIVDLLLTHGADVNMADK 1073
Cdd:pfam00023    5 PLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 864-948 2.90e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  864 LCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVK 943
Cdd:PTZ00322    86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                   ....*
gi 2024484409  944 FLIQC 948
Cdd:PTZ00322   166 LLSRH 170
TPR_12 pfam13424
Tetratricopeptide repeat;
1277-1339 3.46e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 3.46e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024484409 1277 SLLLNLSRCRRKMNDFGMAEEFATKALEL--------KPKSYEAYYARARAKRSSRQFAAALEDLNEAIKL 1339
Cdd:pfam13424    4 TALNNLAAVLRRLGRYDEALELLEKALEIarrllgpdHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 838-946 4.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 4.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  838 IKVSRLLILGganvNYRTEVL---NNAPiLCVQSHLGYTEMVALLLEFGANVDAASESGLTPLGYAAAAGFLSIVVLLCK 914
Cdd:PHA02875    82 KAVEELLDLG----KFADDVFykdGMTP-LHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLID 156

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2024484409  915 KRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 946
Cdd:PHA02875   157 HKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 1286-1347 4.33e-03

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 42.21  E-value: 4.33e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024484409 1286 RRKMNDFGMAEEFATKALELKPkSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQ 1347
Cdd:PRK09782   586 RYIPGQPELALNDLTRSLNIAP-SANAYVARATIYRQRHNVPAAVSDLRAALELEPNNSNYQ 646
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1075-1102 4.38e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 4.38e-03
                           10        20
                   ....*....|....*....|....*...
gi 2024484409 1075 GRTPLMMAASEGHLGTVEFLLAQGASIS 1102
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
TPR_19 pfam14559
Tetratricopeptide repeat;
1290-1350 4.84e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 37.18  E-value: 4.84e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024484409 1290 NDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1350
Cdd:pfam14559    2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALL 62
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1107-1136 4.98e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 4.98e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2024484409 1107 EGLTALSWACLKGHLAVVRALVENGAATDH 1136
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
TPR_12 pfam13424
Tetratricopeptide repeat;
1236-1308 5.02e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 5.02e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024484409 1236 GDMFYKKGKVKEAAQRYQYALKKFpREGFGEDlktfRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPK 1308
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIA-RRLLGPD----HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1310-1343 5.26e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 5.26e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2024484409  1310 YEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1343
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 1021-1101 5.79e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 41.65  E-value: 5.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1021 KLDVCRLLLEQGAAVaqpNRRGVV--PLFSAVRQGHW------QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVE 1092
Cdd:PHA02989    49 KIKIVKLLIDNGADV---NYKGYIetPLCAVLRNREItsnkikKIVKLLLKFGADINLKTFNGVSPIVCFIYNSNINNCD 125

                           90
                   ....*....|..
gi 2024484409 1093 ---FLLAQGASI 1101
Cdd:PHA02989   126 mlrFLLSKGINV 137
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1045-1070 5.82e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 5.82e-03
                            10        20
                    ....*....|....*....|....*.
gi 2024484409  1045 PLFSAVRQGHWQIVDLLLTHGADVNM 1070
Cdd:smart00248    5 PLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1009-1083 6.49e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 6.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1009 GETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGVVPLFSAVRQGHWQIVDLLLTHGADVNMADKQGR------------ 1076
Cdd:PTZ00322   115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANAKpdsftgkppsle 194


                   ....*...
gi 2024484409 1077 -TPLMMAA 1083
Cdd:PTZ00322   195 dSPISSHH 202
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1107-1139 6.80e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 6.80e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024484409 1107 EGLTALSWACLK-GHLAVVRALVENGAATDHADK 1139
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 838-1124 7.62e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 41.27  E-value: 7.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  838 IKVSRLLILGGANVNYR-------TEVLNNAPIlcvqSHLGYTEMVALLLEFGANVDAASESGLTPLG---YAAAAGFLS 907
Cdd:PHA02989    50 IKIVKLLIDNGADVNYKgyietplCAVLRNREI----TSNKIKKIVKLLLKFGADINLKTFNGVSPIVcfiYNSNINNCD 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  908 IVVLLCKKRAKVDHLDKNGQCALVHAALRG---HLEVVKFLIQcdwsmAGqqQGVFKKSHAiqqaliaaasMGYTEIVSY 984
Cdd:PHA02989   126 MLRFLLSKGINVNDVKNSRGYNLLHMYLESfsvKKDVIKILLS-----FG--VNLFEKTSL----------YGLTPMNIY 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  985 LldlpekdeeeveRAQINSFDslwgetaltaaagrgkLDVCRLLLEQGAAVAQPNRRGVVPLFSAVR------QGHWQIV 1058
Cdd:PHA02989   189 L------------RNDIDVIS----------------IKVIKYLIKKGVNIETNNNGSESVLESFLDnnkilsKKEFKVL 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024484409 1059 DLLLTHgADVNMADKQGRTPLMMAASEGHLGTVEFLLAQGASISLMDKEGLTALSWACLKGHLAVV 1124
Cdd:PHA02989   241 NFILKY-IKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDML 305
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 977-1161 7.87e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.02  E-value: 7.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409  977 GYTEIVSYLLDLPEKDEEEVERAQINSFDSLW-GETALTAAAGRGKLDVCRLLLEQGAAV-AQPNRR------------G 1042
Cdd:cd21882     40 GVNEAIMLLLEAAPDSGNPKELVNAPCTDEFYqGQTALHIAIENRNLNLVRLLVENGADVsARATGRffrkspgnlfyfG 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024484409 1043 VVPLFSAVRQGHWQIVDLLLTHGAD---VNMADKQGRTPL--MMAASEGHLGTVEFLLAQGASISLMDKegltalswacl 1117
Cdd:cd21882    120 ELPLSLAACTNQEEIVRLLLENGAQpaaLEAQDSLGNTVLhaLVLQADNTPENSAFVCQMYNLLLSYGA----------- 188

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2024484409 1118 KGHLAVVRALVENgaatdhadKNGRTPLDLAAFYGDAEVVQFLV 1161
Cdd:cd21882    189 HLDPTQQLEEIPN--------HQGLTPLKLAAVEGKIVMFQHIL 224
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1045-1070 8.81e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 8.81e-03
                           10        20
                   ....*....|....*....|....*.
gi 2024484409 1045 PLFSAVRQGHWQIVDLLLTHGADVNM 1070
Cdd:pfam13606    5 PLHLAARNGRLEIVKLLLENGADINA 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1143-1206 9.56e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 9.56e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024484409 1143 TPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQTLP 1206
Cdd:PHA02874    37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPIP 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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