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Conserved domains on  [gi|2024485530|ref|XP_040548345|]
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cyclin N-terminal domain-containing protein 1 isoform X2 [Gallus gallus]

Protein Classification

cyclin family protein( domain architecture ID 1750054)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901|GO:0007049
PubMed:  14744433|30185601|15269391|15840440
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 51-158 4.42e-34

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20541:

Pssm-ID: 477360  Cd Length: 127  Bit Score: 116.15  E-value: 4.42e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024485530  51 FREARTVEFIFLLSEKWHLDQSARYQAVELLERFMIKQVEQICTSPRQNVTGGEQGRSQNSLQEQIHDTFVLRLVSCIQL 130
Cdd:cd20541     1 FKTGRLVEFVFLLCEKLGLPPEVKYLAVELFDRFMSRHIEELYKSVRESNKIKGKKEEWKEVESRLSKQLPLRLVSCVQL 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024485530 131 ASKLSLHYNDIT---AAYFLQNhcirCVYNY 158
Cdd:cd20541    81 ASKLSSHYKIVSankAKNFLQS----LGHPY 107
 
Name Accession Description Interval E-value
CYCLIN_CNTD1 cd20541
cyclin box found in Cyclin N-terminal domain-containing protein 1 (CNTD1) and similar proteins; ...
 51-158 4.42e-34

cyclin box found in Cyclin N-terminal domain-containing protein 1 (CNTD1) and similar proteins; CNTD1 is a cyclin-related protein critical for meiotic crossover maturation and deselection of excess precrossover sites. CNTD1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410244  Cd Length: 127  Bit Score: 116.15  E-value: 4.42e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024485530  51 FREARTVEFIFLLSEKWHLDQSARYQAVELLERFMIKQVEQICTSPRQNVTGGEQGRSQNSLQEQIHDTFVLRLVSCIQL 130
Cdd:cd20541     1 FKTGRLVEFVFLLCEKLGLPPEVKYLAVELFDRFMSRHIEELYKSVRESNKIKGKKEEWKEVESRLSKQLPLRLVSCVQL 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024485530 131 ASKLSLHYNDIT---AAYFLQNhcirCVYNY 158
Cdd:cd20541    81 ASKLSSHYKIVSankAKNFLQS----LGHPY 107
 
Name Accession Description Interval E-value
CYCLIN_CNTD1 cd20541
cyclin box found in Cyclin N-terminal domain-containing protein 1 (CNTD1) and similar proteins; ...
 51-158 4.42e-34

cyclin box found in Cyclin N-terminal domain-containing protein 1 (CNTD1) and similar proteins; CNTD1 is a cyclin-related protein critical for meiotic crossover maturation and deselection of excess precrossover sites. CNTD1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410244  Cd Length: 127  Bit Score: 116.15  E-value: 4.42e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024485530  51 FREARTVEFIFLLSEKWHLDQSARYQAVELLERFMIKQVEQICTSPRQNVTGGEQGRSQNSLQEQIHDTFVLRLVSCIQL 130
Cdd:cd20541     1 FKTGRLVEFVFLLCEKLGLPPEVKYLAVELFDRFMSRHIEELYKSVRESNKIKGKKEEWKEVESRLSKQLPLRLVSCVQL 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024485530 131 ASKLSLHYNDIT---AAYFLQNhcirCVYNY 158
Cdd:cd20541    81 ASKLSSHYKIVSankAKNFLQS----LGHPY 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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