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Conserved domains on  [gi|2024390606|ref|XP_040552977|]
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transport and Golgi organization protein 1 homolog isoform X2 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SH3 super family cl17036
Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction ...
 105-168 1.26e-39

Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. Thus, they are referred to as proline-recognition domains (PRDs). SH3 domains are less selective and show more diverse specificity compared to other PRDs. They have been shown to bind peptide sequences that lack the PxxP motif; examples include the PxxDY motif of Eps8 and the RKxxYxxY sequence in SKAP55. SH3 domain containing proteins play versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others. Many members of this superfamily are adaptor proteins that associate with a number of protein partners, facilitating complex formation and signal transduction.


The actual alignment was detected with superfamily member cd11893:

Pssm-ID: 473055  Cd Length: 73  Bit Score: 141.91  E-value: 1.26e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024390606  105 LMCRGKAMKDFQGPDCRFVNFKKGETVYVYYKLIGMSTELWAGSIGSDFGYFPKDLLEINHNYT 168
Cdd:cd11893     10 LLCRGKAVKDFTGPDCRFLSFKKGETIYVYYKLSGRRTDLWAGSVGFDFGYFPKDLLDVNHLYT 73
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1349-1725 8.12e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 80.45  E-value: 8.12e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQ-------AKESMKVAQEQKSILSDEIAGLKdtvKELEETNHQLDD---KI 1418
Cdd:TIGR04523   71 NNSNNKIKILEQQIKDLNDKLKKNKDKINKlnsdlskINSEIKNDKEQKNKLEVELNKLE---KQKKENKKNIDKfltEI 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1419 KSLRTMLD--TERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVK--------AELQHVQEEN 1488
Cdd:TIGR04523  148 KKKEKELEklNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKiqknksleSQISELKKQN 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1489 ARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIE----VLTNCIMQLKQLDTDsASEAKDGEGL 1564
Cdd:TIGR04523  228 NQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEqnnkKIKELEKQLNQLKSE-ISDLNNQKEQ 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1565 EWSTKddlANGELPDNEKMKTQIKQMMDA-----SRVKTMLSLVEEDRNSLQsklSDEVAARHELEE---QIKKLEHDSS 1636
Cdd:TIGR04523  307 DWNKE---LKSELKNQEKKLEEIQNQISQnnkiiSQLNEQISQLKKELTNSE---SENSEKQRELEEkqnEIEKLKKENQ 380

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1637 SLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKltQEEYERQEKEQKL-------------SAADEKAVLAIeEVK 1703
Cdd:TIGR04523  381 SYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKL--QQEKELLEKEIERlketiiknnseikDLTNQDSVKEL-IIK 457

                          410       420
                   ....*....|....*....|..
gi 2024390606 1704 VYKQRIQDMEEELQKTERSYKN 1725
Cdd:TIGR04523  458 NLDNTRESLETQLKVLSRSINK 479
PTZ00121 super family cl31754
MAEBL; Provisional
 428-946 2.97e-10

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.93  E-value: 2.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  428 ESKHHKLDEYANGATELhnQRDNEEERDSDVLitKDAFSENKKSGDSVNVDMFESEQTKEKRDEAMPVSK--------KE 499
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAA--KKKAEEKKKADEA--KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKadeakkkaEE 1442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  500 APTATQLDDLSEELSRREPVGASDPDAKEKTNKTEQFEEQLLTDETVLHPEELKSTAvpdppvlhspgDGLKFKSFVEGK 579
Cdd:PTZ00121  1443 AKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKA-----------DEAKKAAEAKKK 1511

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  580 QDAL-----SPPAGDVNQSPEGVLLAETEKEEEKFGGDTLKESSEnnfkHRKLWEKMKEKGKAKYEPSGDVLAKPVEDVQ 654
Cdd:PTZ00121  1512 ADEAkkaeeAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE----LKKAEEKKKAEEAKKAEEDKNMALRKAEEAK 1587

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  655 NTSQSDTGDTDllkdKLEQEMPVVEKEILRQEEDLK----QTREADHENQRPISVKKEPEIERGSMKETSADERDPSRRG 730
Cdd:PTZ00121  1588 KAEEARIEEVM----KLYEEEKKMKAEEAKKAEEAKikaeELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA 1663

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  731 AAEQPRPWENETEYSEADVKEELSRNLGKMTIFE-------ERIEKSSPEEKSKS-------------AAQNTNAENSTQ 790
Cdd:PTZ00121  1664 AEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEaeeakkaEELKKKEAEEKKKAeelkkaeeenkikAEEAKKEAEEDK 1743

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  791 QGTAHTDNEDSDRNLGTSSARETTLRLELQSEEPDAEEDPDLKQEEELLEDENAASAKLLQARLANIQ-GNAQTTRstnp 869
Cdd:PTZ00121  1744 KKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIeGGKEGNL---- 1819

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  870 dlgVLSEAVSGTVNPTYETGEKTNSFSEDTKEISRVQ-----DAHEVGNKEVDKPVSEDTKLDEIEHVMED------NKE 938
Cdd:PTZ00121  1820 ---VINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKfnknnENGEDGNKEADFNKEKDLKEDDEEEIEEAdeiekiDKD 1896


                   ....*...
gi 2024390606  939 SSEAEEPS 946
Cdd:PTZ00121  1897 DIEREIPN 1904
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1775-1983 4.20e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 4.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1775 PLIVKPTPGRPDRQVPPRRvplsrdgsfgPSPvsggNPSPTQMMEVPSRPLSAPQREGSRAEFGTVVD--GPPAPRRPPE 1852
Cdd:PHA03247  2554 PLPPAAPPAAPDRSVPPPR----------PAP----RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDprGPAPPSPLPP 2619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1853 LPGRMSVPDLGPAVA--SLISSGPRTSSPATAKDRAPSPKEPEAPRVTTDSPSSIEPATVNVGPKGPPSFPGTPVMTSPV 1930
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAanEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA 2699

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1931 LgppppppvnygpppapfPGHYGPGPRPLPVPLVCGAPLP--PPAARDFLPGPSL 1983
Cdd:PHA03247  2700 D-----------------PPPPPPTPEPAPHALVSATPLPpgPAAARQASPALPA 2737
 
Name Accession Description Interval E-value
SH3_MIA3 cd11893
Src Homology 3 domain of Melanoma Inhibitory Activity 3 protein; MIA3, also called TANGO or ...
 105-168 1.26e-39

Src Homology 3 domain of Melanoma Inhibitory Activity 3 protein; MIA3, also called TANGO or TANGO1, acts as a tumor suppressor of malignant melanoma. It is downregulated or lost in melanoma cells lines. Unlike other MIA family members, MIA3 is widely expressed except in hematopoietic cells. MIA3 is an ER resident transmembrane protein that is required for the loading of collagen VII into transport vesicles. SNPs in the MIA3 gene have been associated with coronary arterial disease and myocardial infarction. MIA3 contains an N-terminal SH3-like domain, similar to MIA. It is a member of the recently identified family that also includes MIA, MIAL, and MIA2. MIA is a single domain protein that adopts a SH3 domain-like fold; it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. Unlike classical SH3 domains, MIA does not bind proline-rich ligands.


Pssm-ID: 212826  Cd Length: 73  Bit Score: 141.91  E-value: 1.26e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024390606  105 LMCRGKAMKDFQGPDCRFVNFKKGETVYVYYKLIGMSTELWAGSIGSDFGYFPKDLLEINHNYT 168
Cdd:cd11893     10 LLCRGKAVKDFTGPDCRFLSFKKGETIYVYYKLSGRRTDLWAGSVGFDFGYFPKDLLDVNHLYT 73
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1349-1725 8.12e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 80.45  E-value: 8.12e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQ-------AKESMKVAQEQKSILSDEIAGLKdtvKELEETNHQLDD---KI 1418
Cdd:TIGR04523   71 NNSNNKIKILEQQIKDLNDKLKKNKDKINKlnsdlskINSEIKNDKEQKNKLEVELNKLE---KQKKENKKNIDKfltEI 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1419 KSLRTMLD--TERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVK--------AELQHVQEEN 1488
Cdd:TIGR04523  148 KKKEKELEklNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKiqknksleSQISELKKQN 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1489 ARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIE----VLTNCIMQLKQLDTDsASEAKDGEGL 1564
Cdd:TIGR04523  228 NQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEqnnkKIKELEKQLNQLKSE-ISDLNNQKEQ 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1565 EWSTKddlANGELPDNEKMKTQIKQMMDA-----SRVKTMLSLVEEDRNSLQsklSDEVAARHELEE---QIKKLEHDSS 1636
Cdd:TIGR04523  307 DWNKE---LKSELKNQEKKLEEIQNQISQnnkiiSQLNEQISQLKKELTNSE---SENSEKQRELEEkqnEIEKLKKENQ 380

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1637 SLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKltQEEYERQEKEQKL-------------SAADEKAVLAIeEVK 1703
Cdd:TIGR04523  381 SYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKL--QQEKELLEKEIERlketiiknnseikDLTNQDSVKEL-IIK 457

                          410       420
                   ....*....|....*....|..
gi 2024390606 1704 VYKQRIQDMEEELQKTERSYKN 1725
Cdd:TIGR04523  458 NLDNTRESLETQLKVLSRSINK 479
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1395-1760 5.62e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 78.05  E-value: 5.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1395 DEIAGL-------KDTVKELEETNHQL---DDKIKSLRTMLDTERKQ--NAKKQKKLSETQKSLEKFEEAFSMH--SAEL 1460
Cdd:COG1196    162 EEAAGIskykerkEEAERKLEATEENLerlEDILGELERQLEPLERQaeKAERYRELKEELKELEAELLLLKLRelEAEL 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1461 SEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEgwserhtELTEQIKLYRKSQKDIEEALAYKENEIEVL 1540
Cdd:COG1196    242 EELEAELEELEAELEELEAELAELEAELEELRLELEELELELE-------EAQAEEYELLAELARLEQDIARLEERRREL 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1541 TNcimQLKQLDTDSASEAKDGEGLEwstkddlangelpdnEKMKTQIKQMMDAsrvktmlslvEEDRNSLQSKLSDEVAA 1620
Cdd:COG1196    315 EE---RLEELEEELAELEEELEELE---------------EELEELEEELEEA----------EEELEEAEAELAEAEEA 366

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1621 RHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELyQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIE 1700
Cdd:COG1196    367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA-EEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1701 EVKVYKQRIQDmEEELQKTERSYKNQIAAHEKKAHDNWLIARSAERALAEEKREAANLRQ 1760
Cdd:COG1196    446 EAAEEEAELEE-EEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
PTZ00121 PTZ00121
MAEBL; Provisional
 1348-1769 4.93e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 75.18  E-value: 4.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSilSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDT 1427
Cdd:PTZ00121  1389 EKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKK--ADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKA 1466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1428 ERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEE--NARLKKSKEQLLKEAEGW 1505
Cdd:PTZ00121  1467 EEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEakKAEEAKKADEAKKAEEKK 1546

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1506 SERHTELTEQIKLYRKSQKdIEEALAYKENeievltncimqlKQLDTDSASEAKDGEGLEWSTKDDLANGElpdnEKMKT 1585
Cdd:PTZ00121  1547 KADELKKAEELKKAEEKKK-AEEAKKAEED------------KNMALRKAEEAKKAEEARIEEVMKLYEEE----KKMKA 1609

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1586 QIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQ 1665
Cdd:PTZ00121  1610 EEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKK 1689

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1666 KEMALQKK---------LTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSyKNQIAAHEKKAHD 1736
Cdd:PTZ00121  1690 AAEALKKEaeeakkaeeLKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEE-KKKIAHLKKEEEK 1768

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2024390606 1737 NWLIARSAERALAEEKREAANLRQKlMEVNQKT 1769
Cdd:PTZ00121  1769 KAEEIRKEKEAVIEEELDEEDEKRR-MEVDKKI 1800
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1337-1733 7.54e-11

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 67.69  E-value: 7.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1337 LSVKSRMYQVTEKQLAEKIQN-LLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLD 1415
Cdd:pfam02463  645 ESGLRKGVSLEEGLAEKSEVKaSLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLA 724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1416 DKIKSLRTMLDTERKQNakKQKKLSETQKSLEKFEEAFSmhsAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSK 1495
Cdd:pfam02463  725 DRVQEAQDKINEELKLL--KQKIDEEEEEEEKSRLKKEE---KEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQ 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1496 EQLLKEAEgwserhTELTEQIKLYRKSQKDIEEALAYKENEIEvltncimqlkQLDTDSASEAKDGEGLEWSTKDDLANG 1575
Cdd:pfam02463  800 EEELRALE------EELKEEAELLEEEQLLIEQEEKIKEEELE----------ELALELKEEQKLEKLAEEELERLEEEI 863

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1576 ELPDNEKMKTQIKQMMDASRVKTMLSLVE-EDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLqsakarlENECKTLQQ 1654
Cdd:pfam02463  864 TKEELLQELLLKEEELEEQKLKDELESKEeKEKEEKKELEEESQKLNLLEEKENEIEERIKEEA-------EILLKYEEE 936

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024390606 1655 KVEILGELYQQKEMALQKKLTQEEYERQEKEQKLSAAdEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKK 1733
Cdd:pfam02463  937 PEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELG-KVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEE 1014
PTZ00121 PTZ00121
MAEBL; Provisional
 428-946 2.97e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.93  E-value: 2.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  428 ESKHHKLDEYANGATELhnQRDNEEERDSDVLitKDAFSENKKSGDSVNVDMFESEQTKEKRDEAMPVSK--------KE 499
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAA--KKKAEEKKKADEA--KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKadeakkkaEE 1442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  500 APTATQLDDLSEELSRREPVGASDPDAKEKTNKTEQFEEQLLTDETVLHPEELKSTAvpdppvlhspgDGLKFKSFVEGK 579
Cdd:PTZ00121  1443 AKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKA-----------DEAKKAAEAKKK 1511

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  580 QDAL-----SPPAGDVNQSPEGVLLAETEKEEEKFGGDTLKESSEnnfkHRKLWEKMKEKGKAKYEPSGDVLAKPVEDVQ 654
Cdd:PTZ00121  1512 ADEAkkaeeAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE----LKKAEEKKKAEEAKKAEEDKNMALRKAEEAK 1587

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  655 NTSQSDTGDTDllkdKLEQEMPVVEKEILRQEEDLK----QTREADHENQRPISVKKEPEIERGSMKETSADERDPSRRG 730
Cdd:PTZ00121  1588 KAEEARIEEVM----KLYEEEKKMKAEEAKKAEEAKikaeELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA 1663

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  731 AAEQPRPWENETEYSEADVKEELSRNLGKMTIFE-------ERIEKSSPEEKSKS-------------AAQNTNAENSTQ 790
Cdd:PTZ00121  1664 AEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEaeeakkaEELKKKEAEEKKKAeelkkaeeenkikAEEAKKEAEEDK 1743

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  791 QGTAHTDNEDSDRNLGTSSARETTLRLELQSEEPDAEEDPDLKQEEELLEDENAASAKLLQARLANIQ-GNAQTTRstnp 869
Cdd:PTZ00121  1744 KKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIeGGKEGNL---- 1819

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  870 dlgVLSEAVSGTVNPTYETGEKTNSFSEDTKEISRVQ-----DAHEVGNKEVDKPVSEDTKLDEIEHVMED------NKE 938
Cdd:PTZ00121  1820 ---VINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKfnknnENGEDGNKEADFNKEKDLKEDDEEEIEEAdeiekiDKD 1896


                   ....*...
gi 2024390606  939 SSEAEEPS 946
Cdd:PTZ00121  1897 DIEREIPN 1904
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1775-1983 4.20e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 4.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1775 PLIVKPTPGRPDRQVPPRRvplsrdgsfgPSPvsggNPSPTQMMEVPSRPLSAPQREGSRAEFGTVVD--GPPAPRRPPE 1852
Cdd:PHA03247  2554 PLPPAAPPAAPDRSVPPPR----------PAP----RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDprGPAPPSPLPP 2619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1853 LPGRMSVPDLGPAVA--SLISSGPRTSSPATAKDRAPSPKEPEAPRVTTDSPSSIEPATVNVGPKGPPSFPGTPVMTSPV 1930
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAanEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA 2699

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1931 LgppppppvnygpppapfPGHYGPGPRPLPVPLVCGAPLP--PPAARDFLPGPSL 1983
Cdd:PHA03247  2700 D-----------------PPPPPPTPEPAPHALVSATPLPpgPAAARQASPALPA 2737
SH3_2 pfam07653
Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in ...
 108-163 6.40e-07

Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 429575 [Multi-domain]  Cd Length: 54  Bit Score: 47.98  E-value: 6.40e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024390606  108 RGKAMKDFQGPDCRFVNFKKGETVYVYYKLIGmstELWAGSIGSDFGYFPKDLLEI 163
Cdd:pfam07653    1 YGRVIFDYVGTDKNGLTLKKGDVVKVLGKDND---GWWEGETGGRVGLVPSTAVEE 53
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 1790-1981 8.83e-06

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 47.94  E-value: 8.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1790 PPrrvPLSRDGSFGPSPVSGGNPSPTQMMEVPSRPlSAPQREGSRAEfgtvvdgPPaprrPPELPGRMSVPdlgpavasl 1869
Cdd:pfam06346    3 PP---PLPGDSSTIPLPPGACIPTPPPLPGGGGPP-PPPPLPGSAAI-------PP----PPPLPGGTSIP--------- 58

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1870 issgprtsSPATAKDRAPSPKEPEAPRVTTDSPSSIEPATVNVGPKgPPSFPGTPVMTSPVlgppppppvnygpppAPFP 1949
Cdd:pfam06346   59 --------PPPPLPGAASIPPPPPLPGSTGIPPPPPLPGGAGIPPP-PPPLPGGAGVPPPP---------------PPLP 114

                          170       180       190
                   ....*....|....*....|....*....|...
gi 2024390606 1950 GhyGPG-PRPLPVPLVCGAPlPPPaardflPGP 1981
Cdd:pfam06346  115 G--GPGiPPPPPFPGGPGIP-PPP------PGM 138
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
 523-713 1.67e-04

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 47.01  E-value: 1.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  523 DPDAKEKTNKTEQFEEQLLTDETVLHPEELKSTAvpdppvlhSPGDGLKFKSFVEGKQDALSPPAGDVNQSPEGVLLAET 602
Cdd:NF033875    61 DPQSGSETPKTAVSEEATVQKDTTSQPTKVEEVA--------SEKNGAEQSSATPNDTTNAQQPTVGAEKSAQEQPVVSP 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  603 EKEEEKFGGDTLKESSENNFKHRKLWEKM-------KEKGKAKYEPSGDVLAKPVEDVQNTSQSDTGDTDLLKDKLEQEM 675
Cdd:NF033875   133 ETTNEPLGQPTEVAPAENEANKSTSIPKEfetpdvdKAVDEAKKDPNITVVEKPAEDLGNVSSKDLAAKEKEVDQLQKEQ 212

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2024390606  676 PvveKEILRQEEDLKQTREADHENQRPISVKKEPEIER 713
Cdd:NF033875   213 A---KKIAQQAAELKAKNEKIAKENAEIAAKNKAEKER 247
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1638-1761 5.91e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 44.11  E-value: 5.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1638 LQSAKARLENECKTLQQKVEILGELYQQKEmALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQ 1717
Cdd:cd16269    151 REKLVEKYRQVPRKGVKAEEVLQEFLQSKE-AEAEAILQADQALTEKEKEIEAERAKAEAAEQERKLLEEQQRELEQKLE 229

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2024390606 1718 KTERSYKNQIAAHEKK-AHDNWLIARSAERALAEEKREAANLRQK 1761
Cdd:cd16269    230 DQERSYEEHLRQLKEKmEEERENLLKEQERALESKLKEQEALLEE 274
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1348-1506 8.67e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.85  E-value: 8.67e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  1348 EKQLAEKIQNLLQEKTEmLDKFSEcdeKIKQAKESMkvaQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSlrtMLDT 1427
Cdd:smart00787  146 KEGLDENLEGLKEDYKL-LMKELE---LLNSIKPKL---RDRKDALEEELRQLKQLEDELEDCDPTELDRAKE---KLKK 215

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024390606  1428 ERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNEsklsEEKVKAELQHVQEENARLKKSKEQLLKEAEGWS 1506
Cdd:smart00787  216 LLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAE----AEKKLEQCRGFTFKEIEKLKEQLKLLQSLTGWK 290
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 1780-1921 2.33e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 42.45  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1780 PTPGRPDRQVP--PRRVPLSRD-GSFGPSPVSGGNPSPTQMMEVPSRPLSA--PQREGSRAEFGTVVDGPPAPRRPPELP 1854
Cdd:NF040712   190 PDFGRPLRPLAtvPRLAREPADaRPEEVEPAPAAEGAPATDSDPAEAGTPDdlASARRRRAGVEQPEDEPVGPGAAPAAE 269

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024390606 1855 GRMSVPDLGPAVASLISSGPrtSSPATAKDRAPSPKEPEAPRVTTDSPSSIEPATVNVGPKGPPSFP 1921
Cdd:NF040712   270 PDEATRDAGEPPAPGAAETP--EAAEPPAPAPAAPAAPAAPEAEEPARPEPPPAPKPKRRRRRASVP 334
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 600-843 3.08e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 42.68  E-value: 3.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  600 AETEKEEEKFGGDTLKESSENNFKHRKLWEkMKEKGKAKYEPSGDVLAKPVE---DVQNTSQSDTGDTDLLKDKLEQEMP 676
Cdd:TIGR00927  655 AEGENGEESGGEAEQEGETETKGENESEGE-IPAERKGEQEGEGEIEAKEADhkgETEAEEVEHEGETEAEGTEDEGEIE 733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  677 VVEKEILRQEEDLKQTrEADHENQRPiSVKKEPEIERGSMKETSADErDPSRRGAAEQPRPWENETEYSEADVKEELSRN 756
Cdd:TIGR00927  734 TGEEGEEVEDEGEGEA-EGKHEVETE-GDRKETEHEGETEAEGKEDE-DEGEIQAGEDGEMKGDEGAEGKVEHEGETEAG 810

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  757 LGKMTIFEERIEKSSPEEKSKSAAQNTNAENstqQGTAHTDNEDSDRNLGTSSARETtlrlELQSEEPDAEEDPDLKQEE 836
Cdd:TIGR00927  811 EKDEHEGQSETQADDTEVKDETGEQELNAEN---QGEAKQDEKGVDGGGGSDGGDSE----EEEEEEEEEEEEEEEEEEE 883


                   ....*..
gi 2024390606  837 ELLEDEN 843
Cdd:TIGR00927  884 EEEEEEN 890
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 1820-1975 8.75e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 39.29  E-value: 8.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1820 VPSRPLSAPQREGSRAEFGTVVDGPPAPRRPPELPGRMSVPDLGPAVASLISSGPRTSSPATA--KDRAPSPKEPEAPRV 1897
Cdd:cd21975     21 VRPDPEGAGLAAGLDVRATREVAKGPGPPGPAWKPDGADSPGLVTAAPHLLAANVLAPLRGPSveGSSLESGDADMGSDS 100

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1898 TTDSPSSIEPATVNVGPKGPPSFPGTPvmtspvlgppppppvnyGPPPAPFPGHYGPGPRPLPVPLVCGAPLPPPAAR 1975
Cdd:cd21975    101 DVAPASGAAASTSPESSSDAASSPSPL-----------------SLLHPGEAGLEPERPRPRVRRGVRRRGVTPAAKR 161
 
Name Accession Description Interval E-value
SH3_MIA3 cd11893
Src Homology 3 domain of Melanoma Inhibitory Activity 3 protein; MIA3, also called TANGO or ...
 105-168 1.26e-39

Src Homology 3 domain of Melanoma Inhibitory Activity 3 protein; MIA3, also called TANGO or TANGO1, acts as a tumor suppressor of malignant melanoma. It is downregulated or lost in melanoma cells lines. Unlike other MIA family members, MIA3 is widely expressed except in hematopoietic cells. MIA3 is an ER resident transmembrane protein that is required for the loading of collagen VII into transport vesicles. SNPs in the MIA3 gene have been associated with coronary arterial disease and myocardial infarction. MIA3 contains an N-terminal SH3-like domain, similar to MIA. It is a member of the recently identified family that also includes MIA, MIAL, and MIA2. MIA is a single domain protein that adopts a SH3 domain-like fold; it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. Unlike classical SH3 domains, MIA does not bind proline-rich ligands.


Pssm-ID: 212826  Cd Length: 73  Bit Score: 141.91  E-value: 1.26e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024390606  105 LMCRGKAMKDFQGPDCRFVNFKKGETVYVYYKLIGMSTELWAGSIGSDFGYFPKDLLEINHNYT 168
Cdd:cd11893     10 LLCRGKAVKDFTGPDCRFLSFKKGETIYVYYKLSGRRTDLWAGSVGFDFGYFPKDLLDVNHLYT 73
SH3_MIA2 cd11892
Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein; MIA2 is expressed ...
 96-168 5.21e-24

Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein; MIA2 is expressed specifically in hepatocytes and its expression is controlled by hepatocyte nuclear factor 1 binding sites in the MIA2 promoter. It inhibits the growth and invasion of hepatocellular carcinomas (HCC) and may act as a tumor suppressor. A mutation in MIA2 in mice resulted in reduced cholesterol and triglycerides. Since MIA2 localizes to ER exit sites, it may function as an ER-to-Golgi trafficking protein that regulates lipid metabolism. MIA2 contains an N-terminal SH3-like domain, similar to MIA. It is a member of the recently identified family that also includes MIA, MIAL, and MIA3 (also called TANGO). MIA is a single domain protein that adopts a SH3 domain-like fold; it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. Unlike classical SH3 domains, MIA does not bind proline-rich ligands.


Pssm-ID: 212825  Cd Length: 73  Bit Score: 97.22  E-value: 5.21e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024390606   96 KCFIKHSIELMCRGKAMKDFQGPDCRFVNFKKGETVYVYYKLIGMSTELWAGSIGSDFGYFPKDLLEINHNYT 168
Cdd:cd11892      1 KCGDPECERLMSRVQAIRDYRGPDCRYLSFKKGDEIIVYYKLSGKREDLWAGSTGKEFGYFPKDAVKVEEVYI 73
SH3_MIA_like cd11760
Src Homology 3 domain of Melanoma Inhibitory Activity protein and similar proteins; MIA is a ...
 105-168 1.21e-23

Src Homology 3 domain of Melanoma Inhibitory Activity protein and similar proteins; MIA is a single domain protein that adopts a SH3 domain-like fold; it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. MIA is secreted from malignant melanoma cells and it plays an important role in melanoma development and invasion. MIA is expressed by chondrocytes in normal tissues and may be important in the cartilage cell phenotype. Unlike classical SH3 domains, MIA does not bind proline-rich ligands. MIA is a member of the recently identified family that also includes MIA-like (MIAL), MIA2, and MIA3 (also called TANGO); the biological functions of this family are not yet fully understood.


Pssm-ID: 212694  Cd Length: 76  Bit Score: 96.40  E-value: 1.21e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024390606  105 LMCRGKAMKDFQGPDCRFVNFKKGETVYVYYKLIGMSTELWAGSIGSD---FGYFPKDLLEINHNYT 168
Cdd:cd11760     10 PISRARALEDYHGPDCRFLNFKKGDTIYVYSKLAGERQDLWAGSVGGDaglFGYFPKNLVQELKVYE 76
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1349-1725 8.12e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 80.45  E-value: 8.12e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQ-------AKESMKVAQEQKSILSDEIAGLKdtvKELEETNHQLDD---KI 1418
Cdd:TIGR04523   71 NNSNNKIKILEQQIKDLNDKLKKNKDKINKlnsdlskINSEIKNDKEQKNKLEVELNKLE---KQKKENKKNIDKfltEI 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1419 KSLRTMLD--TERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVK--------AELQHVQEEN 1488
Cdd:TIGR04523  148 KKKEKELEklNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKiqknksleSQISELKKQN 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1489 ARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIE----VLTNCIMQLKQLDTDsASEAKDGEGL 1564
Cdd:TIGR04523  228 NQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEqnnkKIKELEKQLNQLKSE-ISDLNNQKEQ 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1565 EWSTKddlANGELPDNEKMKTQIKQMMDA-----SRVKTMLSLVEEDRNSLQsklSDEVAARHELEE---QIKKLEHDSS 1636
Cdd:TIGR04523  307 DWNKE---LKSELKNQEKKLEEIQNQISQnnkiiSQLNEQISQLKKELTNSE---SENSEKQRELEEkqnEIEKLKKENQ 380

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1637 SLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKltQEEYERQEKEQKL-------------SAADEKAVLAIeEVK 1703
Cdd:TIGR04523  381 SYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKL--QQEKELLEKEIERlketiiknnseikDLTNQDSVKEL-IIK 457

                          410       420
                   ....*....|....*....|..
gi 2024390606 1704 VYKQRIQDMEEELQKTERSYKN 1725
Cdd:TIGR04523  458 NLDNTRESLETQLKVLSRSINK 479
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1396-1729 4.40e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 78.56  E-value: 4.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1396 EIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERKQNAKKQK-------KLSETQKSLEKFEEAFSMHSAELSEVQIALN 1468
Cdd:TIGR02168  678 EIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKeleelsrQISALRKDLARLEAEVEQLEERIAQLSKELT 757

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1469 ESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLK 1548
Cdd:TIGR02168  758 ELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATE 837

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1549 QLDTDSASEAKDGEGLEWSTKDDLANGELPDnEKMKTQIKQMMDASRVktmlslVEEDRNSLQSKLSDEVAARHELEEQI 1628
Cdd:TIGR02168  838 RRLEDLEEQIEELSEDIESLAAEIEELEELI-EELESELEALLNERAS------LEEALALLRSELEELSEELRELESKR 910

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1629 KKLEHDSSSLQSAKARLENECKTLQQkveilgelyqqkemalqkkltqeeyERQEKEQKLSaadEKAVLAIEEVKVYKQR 1708
Cdd:TIGR02168  911 SELRRELEELREKLAQLELRLEGLEV-------------------------RIDNLQERLS---EEYSLTLEEAEALENK 962

                          330       340
                   ....*....|....*....|.
gi 2024390606 1709 IQDMEEELQKTERSYKNQIAA 1729
Cdd:TIGR02168  963 IEDDEEEARRRLKRLENKIKE 983
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1350-1736 4.80e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 78.19  E-value: 4.80e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1350 QLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQE-------QKSILSDEIAGLKDTVKELEETNHQLDDKIKSLR 1422
Cdd:TIGR02169  678 RLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRkigeiekEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVK 757

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1423 TMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHsaELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEA 1502
Cdd:TIGR02169  758 SELKELEARIEELEEDLHKLEEALNDLEARLSHS--RIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEI 835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1503 EGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNcimQLKQLDtdsaSEAKDgeglewstkddlangelpdnek 1582
Cdd:TIGR02169  836 QELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEA---ALRDLE----SRLGD---------------------- 886

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1583 mktqikqmmdasrvktmlslVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQkvEILGEL 1662
Cdd:TIGR02169  887 --------------------LKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIED--PKGEDE 944

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024390606 1663 YQQKEMALQKKLTQeeyERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTE---RSYKNQIAAHEKKAHD 1736
Cdd:TIGR02169  945 EIPEEELSLEDVQA---ELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEeerKAILERIEEYEKKKRE 1018
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1395-1760 5.62e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 78.05  E-value: 5.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1395 DEIAGL-------KDTVKELEETNHQL---DDKIKSLRTMLDTERKQ--NAKKQKKLSETQKSLEKFEEAFSMH--SAEL 1460
Cdd:COG1196    162 EEAAGIskykerkEEAERKLEATEENLerlEDILGELERQLEPLERQaeKAERYRELKEELKELEAELLLLKLRelEAEL 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1461 SEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEgwserhtELTEQIKLYRKSQKDIEEALAYKENEIEVL 1540
Cdd:COG1196    242 EELEAELEELEAELEELEAELAELEAELEELRLELEELELELE-------EAQAEEYELLAELARLEQDIARLEERRREL 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1541 TNcimQLKQLDTDSASEAKDGEGLEwstkddlangelpdnEKMKTQIKQMMDAsrvktmlslvEEDRNSLQSKLSDEVAA 1620
Cdd:COG1196    315 EE---RLEELEEELAELEEELEELE---------------EELEELEEELEEA----------EEELEEAEAELAEAEEA 366

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1621 RHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELyQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIE 1700
Cdd:COG1196    367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA-EEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1701 EVKVYKQRIQDmEEELQKTERSYKNQIAAHEKKAHDNWLIARSAERALAEEKREAANLRQ 1760
Cdd:COG1196    446 EAAEEEAELEE-EEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1349-1733 6.44e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 77.37  E-value: 6.44e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDE----IAGLKDTVKELEETNHQLDDKIKSLRTM 1424
Cdd:TIGR04523  214 KSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEqnkiKKQLSEKQKELEQNNKKIKELEKQLNQL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1425 ------LDTERKQN---------AKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENA 1489
Cdd:TIGR04523  294 kseisdLNNQKEQDwnkelkselKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIE 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1490 RLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEglewsTK 1569
Cdd:TIGR04523  374 KLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLT-----NQ 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1570 DDLANGELPDNEKMKTQIKQmmdasrvktMLSLVEEDRNSLQSKLSDevaarheLEEQIKKLEHDSSSLQSAKARLENEC 1649
Cdd:TIGR04523  449 DSVKELIIKNLDNTRESLET---------QLKVLSRSINKIKQNLEQ-------KQKELKSKEKELKKLNEEKKELEEKV 512

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1650 KTLQQKVEILgelyQQKEMALQKKLTQEEYERQEKEQKLSAADEkaVLAIEEVKVYKQRIQdmeEELQKTERSYKNQIAA 1729
Cdd:TIGR04523  513 KDLTKKISSL----KEKIEKLESEKKEKESKISDLEDELNKDDF--ELKKENLEKEIDEKN---KEIEELKQTQKSLKKK 583


                   ....
gi 2024390606 1730 HEKK 1733
Cdd:TIGR04523  584 QEEK 587
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1349-1715 3.04e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.48  E-value: 3.04e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKE-------SMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSL 1421
Cdd:TIGR02168  687 EELEEKIAELEKALAELRKELEELEEELEQLRKeleelsrQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEEL 766

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1422 RTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNEsklseekVKAELQHVQEENARLKKSKEQLLKE 1501
Cdd:TIGR02168  767 EERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTL-------LNEEAANLRERLESLERRIAATERR 839

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1502 AEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLkqldtdsaseakdgeglewstkddlangelpdne 1581
Cdd:TIGR02168  840 LEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASL---------------------------------- 885

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1582 kmktqikqmmdasrvktmlslvEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKV----E 1657
Cdd:TIGR02168  886 ----------------------EEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIdnlqE 943

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1658 ILGELYQQKEMALQKKLTQEEYERQEKEQKLSAADEK-----AV--LAIEEVKVYKQRIQDMEEE 1715
Cdd:TIGR02168  944 RLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKikelgPVnlAAIEEYEELKERYDFLTAQ 1008
PTZ00121 PTZ00121
MAEBL; Provisional
 1348-1769 4.93e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 75.18  E-value: 4.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSilSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDT 1427
Cdd:PTZ00121  1389 EKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKK--ADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKA 1466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1428 ERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEE--NARLKKSKEQLLKEAEGW 1505
Cdd:PTZ00121  1467 EEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEakKAEEAKKADEAKKAEEKK 1546

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1506 SERHTELTEQIKLYRKSQKdIEEALAYKENeievltncimqlKQLDTDSASEAKDGEGLEWSTKDDLANGElpdnEKMKT 1585
Cdd:PTZ00121  1547 KADELKKAEELKKAEEKKK-AEEAKKAEED------------KNMALRKAEEAKKAEEARIEEVMKLYEEE----KKMKA 1609

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1586 QIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQ 1665
Cdd:PTZ00121  1610 EEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKK 1689

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1666 KEMALQKK---------LTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSyKNQIAAHEKKAHD 1736
Cdd:PTZ00121  1690 AAEALKKEaeeakkaeeLKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEE-KKKIAHLKKEEEK 1768

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2024390606 1737 NWLIARSAERALAEEKREAANLRQKlMEVNQKT 1769
Cdd:PTZ00121  1769 KAEEIRKEKEAVIEEELDEEDEKRR-MEVDKKI 1800
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1360-1712 1.15e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 73.56  E-value: 1.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1360 QEKTEMLDKFS---ECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELE-ETNHQLddKIKSLRTML-DTE------ 1428
Cdd:TIGR02169  153 VERRKIIDEIAgvaEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRrEREKAE--RYQALLKEKrEYEgyellk 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1429 -----RKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNE-----SKLSEEK---VKAELQHVQEENARLKKSK 1495
Cdd:TIGR02169  231 ekealERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEElnkkiKDLGEEEqlrVKEKIGELEAEIASLERSI 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1496 EQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKdgeglEWSTKDDLANG 1575
Cdd:TIGR02169  311 AEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELE-----EVDKEFAETRD 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1576 ELPDNEKMKTQIKQMMDASrvKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQK 1655
Cdd:TIGR02169  386 ELKDYREKLEKLKREINEL--KRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024390606 1656 VEIlgelYQQKEMALQKKLTQEEYERQEKEQKLSAAdEKAVLAIEEVKVYKQRIQDM 1712
Cdd:TIGR02169  464 LSK----YEQELYDLKEEYDRVEKELSKLQRELAEA-EAQARASEERVRGGRAVEEV 515
MIAL cd11891
Melanoma Inhibitory Activity-Like protein; MIAL is specifically expressed in the cochlea and ...
 109-167 1.73e-12

Melanoma Inhibitory Activity-Like protein; MIAL is specifically expressed in the cochlea and the vestibule of the inner ear and may contribute to inner ear dysfunction in humans. MIAL is a member of the recently identified family that also includes MIA, MIA2, and MIA3 (also called TANGO); MIA is the most studied member of the family. MIA is a single domain protein that adopts a Src Homology 3 (SH3) domain-like fold; it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. MIA is secreted from malignant melanoma cells and it plays an important role in melanoma development and invasion. MIA is expressed by chondrocytes in normal tissues and may be important in the cartilage cell phenotype. Unlike classical SH3 domains, MIA does not bind proline-rich ligands.


Pssm-ID: 212824  Cd Length: 83  Bit Score: 64.88  E-value: 1.73e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024390606  109 GKAMKDFQGPDCRFVNFKKGETVYVYYKLI--GMSTELWAGSIGSD--------FGYFPKDLLEINHNY 167
Cdd:cd11891     14 ARAEDDYNAPDCRFINIKKGQLIYVYSKLVkeNGAGEFWSGSVYSEryvdqmgiVGYFPSNLVKEQTVY 82
MIA cd11890
Melanoma Inhibitory Activity protein; MIA is a single domain protein that adopts a Src ...
 110-183 8.73e-12

Melanoma Inhibitory Activity protein; MIA is a single domain protein that adopts a Src Homology 3 (SH3) domain-like fold; it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. MIA is secreted from malignant melanoma cells and it plays an important role in melanoma development and invasion. MIA is expressed by chondrocytes in normal tissues and may be important in the cartilage cell phenotype. Unlike classical SH3 domains, MIA does not bind proline-rich ligands. It binds peptide ligands with sequence similarity to type III human fibronectin repeats.


Pssm-ID: 212823  Cd Length: 98  Bit Score: 63.36  E-value: 8.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  110 KAMKDFQGPDCRFVNFKKGETVYVYYKLIGMSTELWAGSIGSDF--------GYFPKDLLEINHNYTNEELELPTEETDF 181
Cdd:cd11890     17 VALQDYMAPDCRFIPIQRGQVVYVFSKLKGRGRLFWGGSVQGDYygeqaarlGYFPSSIVQEDQYLKPGKVEVKTDKWDF 96


                   ..
gi 2024390606  182 VC 183
Cdd:cd11890     97 YC 98
PTZ00121 PTZ00121
MAEBL; Provisional
 1348-1774 9.68e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 70.94  E-value: 9.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELE--ETNHQLDDKIKSLRTML 1425
Cdd:PTZ00121  1300 EKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEaaEEKAEAAEKKKEEAKKK 1379

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1426 DTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENAR----LKKSKEQlLKE 1501
Cdd:PTZ00121  1380 ADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKkadeAKKKAEE-AKK 1458

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1502 AEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEglEWSTKDDLANGElpdnE 1581
Cdd:PTZ00121  1459 AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAE--EAKKADEAKKAE----E 1532

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1582 KMKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEvaARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGE 1661
Cdd:PTZ00121  1533 AKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEE--AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1662 LYQQKEMALQK--KLTQEEYERQEKEQkLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQiAAHEKKAHDNWL 1739
Cdd:PTZ00121  1611 EAKKAEEAKIKaeELKKAEEEKKKVEQ-LKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKK-AEEAKKAEEDEK 1688

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2024390606 1740 IARSAERALAEEKREAANLRQKLMEVNQKTIMLQR 1774
Cdd:PTZ00121  1689 KAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKK 1723
PTZ00121 PTZ00121
MAEBL; Provisional
 1348-1774 1.19e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 70.56  E-value: 1.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEMLDKFSEcdeKIKQAKESMKVAQEQKSiLSDEIAGLKDTVKELEETNHQLDDKIKSlrtmldT 1427
Cdd:PTZ00121  1365 KAEAAEKKKEEAKKKADAAKKKAE---EKKKADEAKKKAEEDKK-KADELKKAAAAKKKADEAKKKAEEKKKA------D 1434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1428 ERKQNAKKQKKLSETQKSLEkfeeafsmhsaelsEVQIALNESKLSEEKVKA-ELQHVQEEnarlKKSKEQLLKEAEGWS 1506
Cdd:PTZ00121  1435 EAKKKAEEAKKADEAKKKAE--------------EAKKAEEAKKKAEEAKKAdEAKKKAEE----AKKADEAKKKAEEAK 1496

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1507 ERHTELTEQIKLYRKSQKDIEEALAYKENEIEvltncimqlKQLDTDSASEAKDGEglEWSTKDDLANGElpdnEKMKTQ 1586
Cdd:PTZ00121  1497 KKADEAKKAAEAKKKADEAKKAEEAKKADEAK---------KAEEAKKADEAKKAE--EKKKADELKKAE----ELKKAE 1561

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1587 IKQMMDASRVKtmlslvEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTlqqKVEILGELYQQK 1666
Cdd:PTZ00121  1562 EKKKAEEAKKA------EEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKI---KAEELKKAEEEK 1632

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1667 EMALQKKLTQEEYERqeKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKKAHDnwliARSAE- 1745
Cdd:PTZ00121  1633 KKVEQLKKKEAEEKK--KAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEE----AKKAEe 1706

                          410       420       430
                   ....*....|....*....|....*....|.
gi 2024390606 1746 --RALAEEKREAANLRQKLMEVNQKTIMLQR 1774
Cdd:PTZ00121  1707 lkKKEAEEKKKAEELKKAEEENKIKAEEAKK 1737
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1368-1767 1.25e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 70.05  E-value: 1.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1368 KFSECDEKIKQAKESMKVAQE-----QKSILSDE--IAGLKDTVKELEETNHQLDDKIKSLRTMLD-------------- 1426
Cdd:TIGR04523   34 EEKQLEKKLKTIKNELKNKEKelknlDKNLNKDEekINNSNNKIKILEQQIKDLNDKLKKNKDKINklnsdlskinseik 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1427 TERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNES--------------KLSEEKVKAELQHVQEENARLK 1492
Cdd:TIGR04523  114 NDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLnnkyndlkkqkeelENELNLLEKEKLNIQKNIDKIK 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1493 K---SKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLK-QLDTDSASEAKDGEGLEWST 1568
Cdd:TIGR04523  194 NkllKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQtQLNQLKDEQNKIKKQLSEKQ 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1569 KD-DLANGELPDNEK----MKTQI------KQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSS 1637
Cdd:TIGR04523  274 KElEQNNKKIKELEKqlnqLKSEIsdlnnqKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTN 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1638 LQSAKARLENECKTLQQKVEILGELYQQKemalQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQ 1717
Cdd:TIGR04523  354 SESENSEKQRELEEKQNEIEKLKKENQSY----KQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIE 429

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1718 ----------KTERSYKNQIAAHEKKAHDNWLIARSAERALAEEKREAANLRQKLMEVNQ 1767
Cdd:TIGR04523  430 rlketiiknnSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQK 489
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1348-1768 3.40e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.94  E-value: 3.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNL------LQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSL 1421
Cdd:PRK03918   199 EKELEEVLREIneisseLPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1422 RTMLD--TERKQNAKKQKKLS----ETQKSLEKFEEAFSMHSAELSEVQ--IALNESKLSE-EKVKAELQHVQEENARLK 1492
Cdd:PRK03918   279 EEKVKelKELKEKAEEYIKLSefyeEYLDELREIEKRLSRLEEEINGIEerIKELEEKEERlEELKKKLKELEKRLEELE 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1493 KSKE------QLLKEAEGWSERHTELT-----EQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKqldtDSASEAKDG 1561
Cdd:PRK03918   359 ERHElyeeakAKKEELERLKKRLTGLTpekleKELEELEKAKEEIEEEISKITARIGELKKEIKELK----KAIEELKKA 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1562 EG--------LEWSTKDDLAN---GELPDNEK-MKTQIKQMMDASRVKTMLS--LVEEDRNSLQSKLSDEV-AARHELEE 1626
Cdd:PRK03918   435 KGkcpvcgreLTEEHRKELLEeytAELKRIEKeLKEIEEKERKLRKELRELEkvLKKESELIKLKELAEQLkELEEKLKK 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1627 -QIKKLEHDSSSLQSAKAR---LENECKTLQQKVEILGELYQQKEmALQKKLTQEEYERQEKEQKLSaadEKAVLAIEEV 1702
Cdd:PRK03918   515 yNLEELEKKAEEYEKLKEKlikLKGEIKSLKKELEKLEELKKKLA-ELEKKLDELEEELAELLKELE---ELGFESVEEL 590

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1703 kvyKQRIQDMEEELQK--TERSYKNQIAAHEKKAHDNWLIARSAERALAEEKREAANLRQKLMEVNQK 1768
Cdd:PRK03918   591 ---EERLKELEPFYNEylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKK 655
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1350-1565 4.87e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.42  E-value: 4.87e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1350 QLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTER 1429
Cdd:COG1196    271 ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1430 KQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEGWSERH 1509
Cdd:COG1196    351 EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL 430

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024390606 1510 TELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLE 1565
Cdd:COG1196    431 AELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1337-1733 7.54e-11

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 67.69  E-value: 7.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1337 LSVKSRMYQVTEKQLAEKIQN-LLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLD 1415
Cdd:pfam02463  645 ESGLRKGVSLEEGLAEKSEVKaSLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLA 724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1416 DKIKSLRTMLDTERKQNakKQKKLSETQKSLEKFEEAFSmhsAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSK 1495
Cdd:pfam02463  725 DRVQEAQDKINEELKLL--KQKIDEEEEEEEKSRLKKEE---KEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQ 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1496 EQLLKEAEgwserhTELTEQIKLYRKSQKDIEEALAYKENEIEvltncimqlkQLDTDSASEAKDGEGLEWSTKDDLANG 1575
Cdd:pfam02463  800 EEELRALE------EELKEEAELLEEEQLLIEQEEKIKEEELE----------ELALELKEEQKLEKLAEEELERLEEEI 863

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1576 ELPDNEKMKTQIKQMMDASRVKTMLSLVE-EDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLqsakarlENECKTLQQ 1654
Cdd:pfam02463  864 TKEELLQELLLKEEELEEQKLKDELESKEeKEKEEKKELEEESQKLNLLEEKENEIEERIKEEA-------EILLKYEEE 936

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024390606 1655 KVEILGELYQQKEMALQKKLTQEEYERQEKEQKLSAAdEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKK 1733
Cdd:pfam02463  937 PEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELG-KVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEE 1014
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1348-1762 1.07e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 66.71  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLL----QEKTEMLDKFSECDEKIKQAKESMKV---AQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKS 1420
Cdd:COG4717     48 LERLEKEADELFkpqgRKPELNLKELKELEEELKEAEEKEEEyaeLQEELEELEEELEELEAELEELREELEKLEKLLQL 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1421 LRTM-----LDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNES-KLSEEKVKAELQHVQEENARLKKS 1494
Cdd:COG4717    128 LPLYqeleaLEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELlEQLSLATEEELQDLAEELEELQQR 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1495 KEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIE-VLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDLA 1573
Cdd:COG4717    208 LAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLlLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLA 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1574 NGELPDNEKMKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLS-DEVAARHELEEQIKKLEHdsssLQSAKARLENECKTL 1652
Cdd:COG4717    288 LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGlPPDLSPEELLELLDRIEE----LQELLREAEELEEEL 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1653 QQKV------EILGELYQQKEMALQKKLTQEEyERQEKEQKLSAADE---------KAVLAIEEVKVYKQRIQDMEEELQ 1717
Cdd:COG4717    364 QLEEleqeiaALLAEAGVEDEEELRAALEQAE-EYQELKEELEELEEqleellgelEELLEALDEEELEEELEELEEELE 442

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 2024390606 1718 KTERSYKNqiaAHEKKAHDNWLIAR-SAERALAEEKREAANLRQKL 1762
Cdd:COG4717    443 ELEEELEE---LREELAELEAELEQlEEDGELAELLQELEELKAEL 485
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1348-1647 1.23e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.00  E-value: 1.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEM-----LDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLR 1422
Cdd:TIGR02168  208 QAEKAERYKELKAELRELelallVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQ 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1423 TMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEA 1502
Cdd:TIGR02168  288 KELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAEL 367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1503 EGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNcimQLKQLDTDSASEAKDGEGLEwstkddlanGELPDNEK 1582
Cdd:TIGR02168  368 EELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEA---RLERLEDRRERLQQEIEELL---------KKLEEAEL 435

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1583 MKTQikqmMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLEN 1647
Cdd:TIGR02168  436 KELQ----AELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLER 496
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1349-1768 1.48e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.00  E-value: 1.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLdtE 1428
Cdd:TIGR02168  354 ESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKL--E 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1429 RKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKE----------QL 1498
Cdd:TIGR02168  432 EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQEnlegfsegvkAL 511

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1499 LKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTN-----CIMQLKQ------------LDTDSASEAKDG 1561
Cdd:TIGR02168  512 LKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQAVVVENLnaakkAIAFLKQnelgrvtflpldSIKGTEIQGNDR 591

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1562 EGLEWSTK-----------------------------DDLANG------------------------------------- 1575
Cdd:TIGR02168  592 EILKNIEGflgvakdlvkfdpklrkalsyllggvlvvDDLDNAlelakklrpgyrivtldgdlvrpggvitggsaktnss 671

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1576 ------ELPDNEK-------------------------MKTQIKQMMDA--------SRVKTMLSLVEEDRNSLQSKLSD 1616
Cdd:TIGR02168  672 ilerrrEIEELEEkieeleekiaelekalaelrkeleeLEEELEQLRKEleelsrqiSALRKDLARLEAEVEQLEERIAQ 751

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1617 EVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVE-ILGELYQQKEM--ALQKKLTQEEYERQEKEQKLSAADE 1693
Cdd:TIGR02168  752 LSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEqLKEELKALREAldELRAELTLLNEEAANLRERLESLER 831

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1694 KAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEK--KAHDNWLIAR-SAERALAEEKREAANLRQKLMEVNQK 1768
Cdd:TIGR02168  832 RIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEEleSELEALLNERaSLEEALALLRSELEELSEELRELESK 909
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1344-1758 1.51e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.63  E-value: 1.51e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1344 YQVTEKQLAEkIQNLLQEKTEMLDKF----SECDEKIKQAKESM-KVAQEQKSI------LSDEIAGLKDTVKELEETNh 1412
Cdd:PRK03918   160 YENAYKNLGE-VIKEIKRRIERLEKFikrtENIEELIKEKEKELeEVLREINEIsselpeLREELEKLEKEVKELEELK- 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1413 qldDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEafsmHSAELSEVQIALNESKLSEE---KVKAELQHVQEENA 1489
Cdd:PRK03918   238 ---EEIEELEKELESLEGSKRKLEEKIRELEERIEELKK----EIEELEEKVKELKELKEKAEeyiKLSEFYEEYLDELR 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1490 RLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEaLAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLewsTK 1569
Cdd:PRK03918   311 EIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKE-LEKRLEELEERHELYEEAKAKKEELERLKKRLTGL---TP 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1570 DDLANgELPDNEKMKTQIkqMMDASRVKTMLSLVEEDRNSLQSKLSD-------------EVAARHELE------EQIKK 1630
Cdd:PRK03918   387 EKLEK-ELEELEKAKEEI--EEEISKITARIGELKKEIKELKKAIEElkkakgkcpvcgrELTEEHRKElleeytAELKR 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1631 LEHDSSSLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYERQEKEqKLSAADEKAVLAIEEVKVYKQRIQ 1710
Cdd:PRK03918   464 IEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLE-ELEKKAEEYEKLKEKLIKLKGEIK 542

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 2024390606 1711 DMEEELQKTErSYKNQIAAHEKKAHDnwliarsAERALAEEKREAANL 1758
Cdd:PRK03918   543 SLKKELEKLE-ELKKKLAELEKKLDE-------LEEELAELLKELEEL 582
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1374-1730 2.32e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 66.23  E-value: 2.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1374 EKIKQAKesmkvAQEQKSILsDEIAGL-------KDTVKELEETNH---QLDDKIKSLRTMLDTERKQ--NAKKQKKLSE 1441
Cdd:TIGR02168  147 SEIIEAK-----PEERRAIF-EEAAGIskykerrKETERKLERTREnldRLEDILNELERQLKSLERQaeKAERYKELKA 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1442 TQKSLEKFEEAFSMHSA--ELSEVQIALNESKLSEEKVKAELQHVQEENARLKKskeqllkeaegwseRHTELTEQIKLY 1519
Cdd:TIGR02168  221 ELRELELALLVLRLEELreELEELQEELKEAEEELEELTAELQELEEKLEELRL--------------EVSELEEEIEEL 286

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1520 RKSQKDIEEALAYKENEIEVLTNcimQLKQLDTDSasEAKDGEGLEWSTKDDLANGELPDNEKMKTQIKQMMDAsrvktM 1599
Cdd:TIGR02168  287 QKELYALANEISRLEQQKQILRE---RLANLERQL--EELEAQLEELESKLDELAEELAELEEKLEELKEELES-----L 356

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1600 LSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKLTQEEY 1679
Cdd:TIGR02168  357 EAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELK 436

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024390606 1680 ERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAH 1730
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQL 487
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1345-1538 2.79e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 2.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1345 QVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRtm 1424
Cdd:TIGR02168  753 SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLE-- 830

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1425 ldterKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEG 1504
Cdd:TIGR02168  831 -----RRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRE 905

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2024390606 1505 WSERHTELTEQIKLYRKSQKDIEEALAYKENEIE 1538
Cdd:TIGR02168  906 LESKRSELRRELEELREKLAQLELRLEGLEVRID 939
PTZ00121 PTZ00121
MAEBL; Provisional
 428-946 2.97e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.93  E-value: 2.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  428 ESKHHKLDEYANGATELhnQRDNEEERDSDVLitKDAFSENKKSGDSVNVDMFESEQTKEKRDEAMPVSK--------KE 499
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAA--KKKAEEKKKADEA--KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKadeakkkaEE 1442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  500 APTATQLDDLSEELSRREPVGASDPDAKEKTNKTEQFEEQLLTDETVLHPEELKSTAvpdppvlhspgDGLKFKSFVEGK 579
Cdd:PTZ00121  1443 AKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKA-----------DEAKKAAEAKKK 1511

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  580 QDAL-----SPPAGDVNQSPEGVLLAETEKEEEKFGGDTLKESSEnnfkHRKLWEKMKEKGKAKYEPSGDVLAKPVEDVQ 654
Cdd:PTZ00121  1512 ADEAkkaeeAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE----LKKAEEKKKAEEAKKAEEDKNMALRKAEEAK 1587

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  655 NTSQSDTGDTDllkdKLEQEMPVVEKEILRQEEDLK----QTREADHENQRPISVKKEPEIERGSMKETSADERDPSRRG 730
Cdd:PTZ00121  1588 KAEEARIEEVM----KLYEEEKKMKAEEAKKAEEAKikaeELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA 1663

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  731 AAEQPRPWENETEYSEADVKEELSRNLGKMTIFE-------ERIEKSSPEEKSKS-------------AAQNTNAENSTQ 790
Cdd:PTZ00121  1664 AEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEaeeakkaEELKKKEAEEKKKAeelkkaeeenkikAEEAKKEAEEDK 1743

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  791 QGTAHTDNEDSDRNLGTSSARETTLRLELQSEEPDAEEDPDLKQEEELLEDENAASAKLLQARLANIQ-GNAQTTRstnp 869
Cdd:PTZ00121  1744 KKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIeGGKEGNL---- 1819

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  870 dlgVLSEAVSGTVNPTYETGEKTNSFSEDTKEISRVQ-----DAHEVGNKEVDKPVSEDTKLDEIEHVMED------NKE 938
Cdd:PTZ00121  1820 ---VINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKfnknnENGEDGNKEADFNKEKDLKEDDEEEIEEAdeiekiDKD 1896


                   ....*...
gi 2024390606  939 SSEAEEPS 946
Cdd:PTZ00121  1897 DIEREIPN 1904
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1348-1766 4.07e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 65.34  E-value: 4.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKEsmkvAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDT 1427
Cdd:COG1196    350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEE----LAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEE 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1428 ERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLK---KSKEQLLKEAEG 1504
Cdd:COG1196    426 LEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAarlLLLLEAEADYEG 505

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1505 WSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTK---------DDLANG 1575
Cdd:COG1196    506 FLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKagratflplDKIRAR 585

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1576 ELPDNEKMKTQIKQMM----------DASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHD------SSSLQ 1639
Cdd:COG1196    586 AALAAALARGAIGAAVdlvasdlreaDARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEggsaggSLTGG 665

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1640 SAKARLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKT 1719
Cdd:COG1196    666 SRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEE 745

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1720 ERSYKNQIAAHEKKAhdnwliarsaerALAEEKREAANLRQKLME---VN 1766
Cdd:COG1196    746 ELLEEEALEELPEPP------------DLEELERELERLEREIEAlgpVN 783
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1354-1774 4.46e-10

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 64.86  E-value: 4.46e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1354 KIQNLLQEKTEMLDKFsecdeKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERKQNA 1433
Cdd:PRK04778    83 DIEEQLFEAEELNDKF-----RFRKAKHEINEIESLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELRKSLL 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1434 KKQKKLSETQKSLEKFEEAFsmhSAELSEVqIALNESKlSEEKVKAELQHVQEENARLKKSKEQ---LLKEAEgwserhT 1510
Cdd:PRK04778   158 ANRFSFGPALDELEKQLENL---EEEFSQF-VELTESG-DYVEAREILDQLEEELAALEQIMEEipeLLKELQ------T 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1511 ELTEQIK-L---YRK--------SQKDIEEALAYKENEIEvltNCIMQLKQLDTDSASEAkdgeglewstkddlangelp 1578
Cdd:PRK04778   227 ELPDQLQeLkagYRElveegyhlDHLDIEKEIQDLKEQID---ENLALLEELDLDEAEEK-------------------- 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1579 dNEKMKTQIKQMMDAsrvktmlslveedrnslqskLSDEVAARHELEEQIKKLehdSSSLQSAKARLenecKTLQQKVEI 1658
Cdd:PRK04778   284 -NEEIQERIDQLYDI--------------------LEREVKARKYVEKNSDTL---PDFLEHAKEQN----KELKEEIDR 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1659 LGELYQQKEMALQKkltQEEYERQEKEqkLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQiaaHEKkahdnw 1738
Cdd:PRK04778   336 VKQSYTLNESELES---VRQLEKQLES--LEKQYDEITERIAEQEIAYSELQEELEEILKQLEEIEKE---QEK------ 401

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 2024390606 1739 liARSAERALAEEKREAanlRQKLMEVNQKTIMLQR 1774
Cdd:PRK04778   402 --LSEMLQGLRKDELEA---REKLERYRNKLHEIKR 432
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1345-1724 8.22e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 64.27  E-value: 8.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1345 QVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQakesmkvaqeqksiLSDEIAGLKDTVKELEETNHQLDDKIKSLRTM 1424
Cdd:TIGR04523  306 QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQ--------------LNEQISQLKKELTNSESENSEKQRELEEKQNE 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1425 LDTERKQNAKKQKKLSETQKSLEKFEeafsmhsaelSEVQIALNESKLSEEKVKaelqhvqeenaRLKKSKEQLLKEaeg 1504
Cdd:TIGR04523  372 IEKLKKENQSYKQEIKNLESQINDLE----------SKIQNQEKLNQQKDEQIK-----------KLQQEKELLEKE--- 427

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1505 wserHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLK-QLDTDSASEAKDGEGLEWSTKddlangELPDNEKM 1583
Cdd:TIGR04523  428 ----IERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLEtQLKVLSRSINKIKQNLEQKQK------ELKSKEKE 497

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1584 KTQIKQmmdasrVKTMLSLVEEDRNSLQSKLSDEVaarHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGely 1663
Cdd:TIGR04523  498 LKKLNE------EKKELEEKVKDLTKKISSLKEKI---EKLESEKKEKESKISDLEDELNKDDFELKKENLEKEIDE--- 565

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024390606 1664 QQKEMAlQKKLTQEEYER-QEKEQKLSAADEKAVLAI-EEVKVYKQRIQDMEEELQKTERSYK 1724
Cdd:TIGR04523  566 KNKEIE-ELKQTQKSLKKkQEEKQELIDQKEKEKKDLiKEIEEKEKKISSLEKELEKAKKENE 627
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 1338-1724 9.78e-10

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 63.55  E-value: 9.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1338 SVKSRMYQVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKEsMKVAQEQKSILSDEIAGLKDTVKELEETNhqldDK 1417
Cdd:pfam05622   55 TPGGKKYLLLQKQLEQLQEENFRLETARDDYRIKCEELEKEVLE-LQHRNEELTSLAEEAQALKDEMDILRESS----DK 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1418 IKSLRTMLDTERKQ-----NAKKQKKLSE------TQKSLEKFEEAFSMHSA----ELSEVQIALNESKLSEEKVKA--- 1479
Cdd:pfam05622  130 VKKLEATVETYKKKledlgDLRRQVKLLEernaeyMQRTLQLEEELKKANALrgqlETYKRQVQELHGKLSEESKKAdkl 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1480 --ELQHVQEENARLKKSKEQLLkeaegwSERHT--ELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSA 1555
Cdd:pfam05622  210 efEYKKLEEKLEALQKEKERLI------IERDTlrETNEELRCAQLQQAELSQADALLSPSSDPGDNLAAEIMPAEIREK 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1556 -----SEAKD-GEGLEWSTKDDLA--NGELPD----NEKMKTQIKqmMDASRVKTMLSLVEEDRNSLQ---SKLSDEVAA 1620
Cdd:pfam05622  284 lirlqHENKMlRLGQEGSYRERLTelQQLLEDanrrKNELETQNR--LANQRILELQQQVEELQKALQeqgSKAEDSSLL 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1621 RHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVeilgelyQQKEMALQKKLTQEEYERQEKEQKLSAADEKA----- 1695
Cdd:pfam05622  362 KQKLEEHLEKLHEAQSELQKKKEQIEELEPKQDSNL-------AQKIDELQEALRKKDEDMKAMEERYKKYVEKAksvik 434

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 2024390606 1696 -------VLAIEEVKVYKQRIQDMEEELQKTERSYK 1724
Cdd:pfam05622  435 tldpkqnPASPPEIQALKNQLLEKDKKIEHLERDFE 470
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1390-1751 1.96e-09

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 61.84  E-value: 1.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1390 KSILSDEIAGLKDTVKELEETNHQLDDK---IKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQia 1466
Cdd:COG4372     30 SEQLRKALFELDKLQEELEQLREELEQAreeLEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQ-- 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1467 lneskLSEEKVKAELQHVQEENARLKKSKEQLlkeaegwSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNcimQ 1546
Cdd:COG4372    108 -----EEAEELQEELEELQKERQDLEQQRKQL-------EAQIAELQSEIAEREEELKELEEQLESLQEELAALEQ---E 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1547 LKQLDTDSASEAKDGEGLEwstkddlANGELPDNEKMKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEE 1626
Cdd:COG4372    173 LQALSEAEAEQALDELLKE-------ANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELE 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1627 QIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYK 1706
Cdd:COG4372    246 EDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELA 325

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2024390606 1707 QRIQDMEEELQKTERSYKNQIAAHEKKAHDNWLIARSAERALAEE 1751
Cdd:COG4372    326 KKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVADG 370
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1349-1764 2.27e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.77  E-value: 2.27e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQkSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTE 1428
Cdd:PRK03918   255 RKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEY-IKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKEL 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1429 RKQNAKK----------QKKLSETQKSLEKFEEAFSM------HSAELSEVQIALNESKLSE-----EKVKAELQHVQEE 1487
Cdd:PRK03918   334 EEKEERLeelkkklkelEKRLEELEERHELYEEAKAKkeelerLKKRLTGLTPEKLEKELEElekakEEIEEEISKITAR 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1488 NARLKKSKEQL------LKEAEG--------WSERHTEltEQIKLYRKSQKDIEEALAYKENEIEVLTNcimQLKQLDTD 1553
Cdd:PRK03918   414 IGELKKEIKELkkaieeLKKAKGkcpvcgreLTEEHRK--ELLEEYTAELKRIEKELKEIEEKERKLRK---ELRELEKV 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1554 SASEAkdgeglEWSTKDDLAngELPDNEKMKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLS---DEVAARHELEEQIKK 1630
Cdd:PRK03918   489 LKKES------ELIKLKELA--EQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKslkKELEKLEELKKKLAE 560

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1631 LEHDSSSLQSAKARLENECKTLQQK-VEILGELYQQKEMALQK--KLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQ 1707
Cdd:PRK03918   561 LEKKLDELEEELAELLKELEELGFEsVEELEERLKELEPFYNEylELKDAEKELEREEKELKKLEEELDKAFEELAETEK 640

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024390606 1708 RIQDMEEELQKTERSYKNQiaAHEKKaHDNWLIARSAERALAEEKREAANLRQKLME 1764
Cdd:PRK03918   641 RLEELRKELEELEKKYSEE--EYEEL-REEYLELSRELAGLRAELEELEKRREEIKK 694
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1348-1788 2.34e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 62.65  E-value: 2.34e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDT 1427
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1428 ERKQNAKKQKKLSETQKSL-------EKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLK 1500
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEeallerlERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1501 EAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQ--LDTDSASEAKDGEGLEWSTKDDLANGELP 1578
Cdd:COG1196    471 EAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLrgLAGAVAVLIGVEAAYEAALEAALAAALQN 550

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1579 DNEKMKTQIKQMMDASRVK-----TMLSLVEEDRNSLQSKLSDEVA----------ARHELEEQIKKLEHDSSSLQSAKA 1643
Cdd:COG1196    551 IVVEDDEVAAAAIEYLKAAkagraTFLPLDKIRARAALAAALARGAigaavdlvasDLREADARYYVLGDTLLGRTLVAA 630

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1644 RLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSY 1723
Cdd:COG1196    631 RLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELA 710

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1724 KNQIAAHEkkahdnwliarsAERALAEEKREAANLRQKLMEVNQKTIMLQRPLIVKPTPGRPDRQ 1788
Cdd:COG1196    711 EAEEERLE------------EELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1339-1721 2.47e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 62.75  E-value: 2.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1339 VKSRMYQVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVA----------QEQKSILSDEIAGLKDTVKELE 1408
Cdd:PRK02224   192 LKAQIEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEAdevleeheerREELETLEAEIEDLRETIAETE 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1409 ETNHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSE-------EKVKAEL 1481
Cdd:PRK02224   272 REREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAqahneeaESLREDA 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1482 QHVQEENARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDG 1561
Cdd:PRK02224   352 DDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAEL 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1562 EGLEWSTKDDLANGE-LPDNEKMKTQIKQMMDASRVKTmlslVEEDRNSLqSKLSDEVAarhELEEQIKKLEHDSSSLQS 1640
Cdd:PRK02224   432 EATLRTARERVEEAEaLLEAGKCPECGQPVEGSPHVET----IEEDRERV-EELEAELE---DLEEEVEEVEERLERAED 503

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1641 AKArLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYER----------QEKEQKLSAADEKAVLAIEEVKVYKQRIQ 1710
Cdd:PRK02224   504 LVE-AEDRIERLEERREDLEELIAERRETIEEKRERAEELReraaeleaeaEEKREAAAEAEEEAEEAREEVAELNSKLA 582

                          410
                   ....*....|.
gi 2024390606 1711 DMEEELQKTER 1721
Cdd:PRK02224   583 ELKERIESLER 593
PTZ00121 PTZ00121
MAEBL; Provisional
 1374-1768 2.87e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.85  E-value: 2.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1374 EKIKQAKESMKVAQEQKSIlsdEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERK----QNAKKQKKLSETQKSLE-- 1447
Cdd:PTZ00121  1112 EEARKAEEAKKKAEDARKA---EEARKAEDARKAEEARKAEDAKRVEIARKAEDARKaeeaRKAEDAKKAEAARKAEEvr 1188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1448 ------KFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEEnarlKKSKEQLLKEAEgwSERHTELTEQIKLYRK 1521
Cdd:PTZ00121  1189 kaeelrKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE----AKKDAEEAKKAE--EERNNEEIRKFEEARM 1262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1522 SQKDIEEAL--AYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDLANGELpdnEKMKTQIKQMMDASRVKTm 1599
Cdd:PTZ00121  1263 AHFARRQAAikAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEA---KKKAEEAKKKADAAKKKA- 1338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1600 lslvEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLEneckTLQQKVEILGELYQQKEMALQKKLTQEEY 1679
Cdd:PTZ00121  1339 ----EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKAD----AAKKKAEEKKKADEAKKKAEEDKKKADEL 1410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1680 ERQEKEQKLSaadEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKKAHDNWLIARSAERA--LAEEKREAAN 1757
Cdd:PTZ00121  1411 KKAAAAKKKA---DEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAkkKAEEAKKADE 1487

                          410
                   ....*....|.
gi 2024390606 1758 LRQKLMEVNQK 1768
Cdd:PTZ00121  1488 AKKKAEEAKKK 1498
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1345-1721 4.14e-09

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 61.68  E-value: 4.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1345 QVTEKQLAEKiQNLLQEKTEM---LDKFSECDEKIKQAKESMKV-AQEQKSILSDEIAGLK-----------DTVKELEE 1409
Cdd:pfam05557   58 RLLEKREAEA-EEALREQAELnrlKKKYLEALNKKLNEKESQLAdAREVISCLKNELSELRrqiqraelelqSTNSELEE 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1410 TNHQLDDKIKSLRTMldTERKQN-AKKQKKLSETQKSLEKFEEAFSMHSAElSEVQIALNESKLSEEKVKAELQHVQEEN 1488
Cdd:pfam05557  137 LQERLDLLKAKASEA--EQLRQNlEKQQSSLAEAEQRIKELEFEIQSQEQD-SEIVKNSKSELARIPELEKELERLREHN 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1489 ARLKKSKE--QLLKE-AEGWserhtelteQIKLYRksQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSaseakdgeGLE 1565
Cdd:pfam05557  214 KHLNENIEnkLLLKEeVEDL---------KRKLER--EEKYREEAATLELEKEKLEQELQSWVKLAQDT--------GLN 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1566 WSTKDDLANgelpdnekmktQIKQMMdasrvKTMLSLVEEdRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARL 1645
Cdd:pfam05557  275 LRSPEDLSR-----------RIEQLQ-----QREIVLKEE-NSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRH 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1646 ENECKTLQQKVEILG---ELYQQKEMALQKKLTQEEYERQEKEQKLSAAD-------------EKAVLAIEEVKVYKQRI 1709
Cdd:pfam05557  338 KALVRRLQRRVLLLTkerDGYRAILESYDKELTMSNYSPQLLERIEEAEDmtqkmqahneemeAQLSVAEEELGGYKQQA 417

                          410
                   ....*....|..
gi 2024390606 1710 QDMEEELQKTER 1721
Cdd:pfam05557  418 QTLERELQALRQ 429
PTZ00121 PTZ00121
MAEBL; Provisional
 1348-1737 4.23e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.08  E-value: 4.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEMlDKFSECDEKIKQAKESMKVAQEQKSilSDEIAGLKDTVKELEETNHQLDD-KIKSLRTMLD 1426
Cdd:PTZ00121  1429 EKKKADEAKKKAEEAKKA-DEAKKKAEEAKKAEEAKKKAEEAKK--ADEAKKKAEEAKKADEAKKKAEEaKKKADEAKKA 1505

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1427 TERKQNAKKQKKLSETQKS--LEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEG 1504
Cdd:PTZ00121  1506 AEAKKKADEAKKAEEAKKAdeAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1505 WSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNcimQLKQldtdSASEAKDGEGLEWSTKDDLANGELPDNEKMK 1584
Cdd:PTZ00121  1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE---ELKK----AEEEKKKVEQLKKKEAEEKKKAEELKKAEEE 1658

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1585 TQIKQMMDASRVKtmlslvEEDRNSLQSKLSDEvaARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQkVEILGELYQ 1664
Cdd:PTZ00121  1659 NKIKAAEEAKKAE------EDKKKAEEAKKAEE--DEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEE-LKKAEEENK 1729

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024390606 1665 QKEMALQKKLTQE----EYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKKAHDN 1737
Cdd:PTZ00121  1730 IKAEEAKKEAEEDkkkaEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDN 1806
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1352-1578 5.92e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.55  E-value: 5.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1352 AEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERKQ 1431
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1432 NAKKQKKLSE----TQKSLEKFEEAFSMHSAELSEVQIAL-------NESKLSEEKVKAELQHVQEENARLKKSKEQLLK 1500
Cdd:COG4942     99 LEAQKEELAEllraLYRLGRQPPLALLLSPEDFLDAVRRLqylkylaPARREQAEELRADLAELAALRAELEAERAELEA 178

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1501 EAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDLANGELP 1578
Cdd:COG4942    179 LLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKGKLP 256
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1346-1737 7.65e-09

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 60.64  E-value: 7.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1346 VTEKQLAEkIQNLLQEKTEMLDKFsecdeKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTML 1425
Cdd:pfam06160   57 IVTKSLPD-IEELLFEAEELNDKY-----RFKKAKKALDEIEELLDDIEEDIKQILEELDELLESEEKNREEVEELKDKY 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1426 DTERKQNAKKQKKLSETQKSLEKfeeafsmhsaELSEVQIALNE-SKLSE----EKVKAELQHVQEENARLKKSKEQ--- 1497
Cdd:pfam06160  131 RELRKTLLANRFSYGPAIDELEK----------QLAEIEEEFSQfEELTEsgdyLEAREVLEKLEEETDALEELMEDipp 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1498 LLKEAEgwserhTELTEQIK----LYRKSQK--------DIEEALAYKENEIEvltNCIMQLKQLDTDSASEAkdgegle 1565
Cdd:pfam06160  201 LYEELK------TELPDQLEelkeGYREMEEegyalehlNVDKEIQQLEEQLE---ENLALLENLELDEAEEA------- 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1566 wstkddlangelpdNEKMKTQIKQMMDAsrvktmlslveedrnslqskLSDEVAARHELEEQIKKLEhdsSSLQSAKARL 1645
Cdd:pfam06160  265 --------------LEEIEERIDQLYDL--------------------LEKEVDAKKYVEKNLPEIE---DYLEHAEEQN 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1646 enecKTLQQKVEILGELYQ------QKEMALQKKLTQEEYERQEKEQKLsaADEKAV--LAIEEVKVYKQRIQDMEEElQ 1717
Cdd:pfam06160  308 ----KELKEELERVQQSYTlnenelERVRGLEKQLEELEKRYDEIVERL--EEKEVAysELQEELEEILEQLEEIEEE-Q 380

                          410       420
                   ....*....|....*....|
gi 2024390606 1718 KTERSYKNQIAAHEKKAHDN 1737
Cdd:pfam06160  381 EEFKESLQSLRKDELEAREK 400
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1337-1656 1.22e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 60.47  E-value: 1.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1337 LSVKSRMYQVTEKQLaEKIQNLLQEKTEMLDKFSECDEKIKQAKESM-----KVAQEQKSILSDEIAGLKDTVKELEETN 1411
Cdd:TIGR02169  225 GYELLKEKEALERQK-EAIERQLASLEEELEKLTEEISELEKRLEEIeqlleELNKKIKDLGEEEQLRVKEKIGELEAEI 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1412 HQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARL 1491
Cdd:TIGR02169  304 ASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAET 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1492 KKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLtncIMQLKQLDTDsaseakdgeglewstKDD 1571
Cdd:TIGR02169  384 RDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGI---EAKINELEEE---------------KED 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1572 LAngelpdnEKMKTQikqmmdasrvktmlslvEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKT 1651
Cdd:TIGR02169  446 KA-------LEIKKQ-----------------EWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARA 501


                   ....*
gi 2024390606 1652 LQQKV 1656
Cdd:TIGR02169  502 SEERV 506
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1366-1776 1.69e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.08  E-value: 1.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1366 LDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKS 1445
Cdd:PRK03918   157 LDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEEL 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1446 LEKFEEafsmhsaelSEVQIALNESKLS--EEKVKAELQHVQEENARLKKSKEQL--LKEAEGWSERHTELTEQIKLYRK 1521
Cdd:PRK03918   237 KEEIEE---------LEKELESLEGSKRklEEKIRELEERIEELKKEIEELEEKVkeLKELKEKAEEYIKLSEFYEEYLD 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1522 SQKDIEEALAYKENEIEVLtncIMQLKQLDTDSaSEAKDGEGLEWSTKDDLAngELPDNEKMKTQIKQMMD-ASRVKTML 1600
Cdd:PRK03918   308 ELREIEKRLSRLEEEINGI---EERIKELEEKE-ERLEELKKKLKELEKRLE--ELEERHELYEEAKAKKEeLERLKKRL 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1601 SLVEEDRnsLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLE---NECKTLQQKVEILG-ELYQQKEMALQKKLTq 1676
Cdd:PRK03918   382 TGLTPEK--LEKELEELEKAKEEIEEEISKITARIGELKKEIKELKkaiEELKKAKGKCPVCGrELTEEHRKELLEEYT- 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1677 EEYERQEKEQKlsaadekavLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKKAHDNWLIARSAERaLAEEKREAA 1756
Cdd:PRK03918   459 AELKRIEKELK---------EIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEE-LEKKAEEYE 528

                          410       420
                   ....*....|....*....|
gi 2024390606 1757 NLRQKLMEVNQKTIMLQRPL 1776
Cdd:PRK03918   529 KLKEKLIKLKGEIKSLKKEL 548
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1347-1768 1.70e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 59.74  E-value: 1.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1347 TEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLD 1426
Cdd:pfam05483  367 TEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQ 446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1427 TERKQNAKKQKKLSETQKSLEKF-----EEAFSMHSAELSEVQIALNESKLSEEKVKA---------ELQHVQEENARLK 1492
Cdd:pfam05483  447 AREKEIHDLEIQLTAIKTSEEHYlkeveDLKTELEKEKLKNIELTAHCDKLLLENKELtqeasdmtlELKKHQEDIINCK 526

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1493 KSKEQLLKEAEGWSERHTELTEQIKLYRKSqkdieeaLAYKENEIevltncimqlkQLDTDSASEAKDGEGLEWSTKDDL 1572
Cdd:pfam05483  527 KQEERMLKQIENLEEKEMNLRDELESVREE-------FIQKGDEV-----------KCKLDKSEENARSIEYEVLKKEKQ 588

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1573 ANGELPDNEKMKTQIKqmmdaSRVKTMLSLVEEDRnSLQSKLSDEVAARHELEEQIKKLEHDsssLQSAKARLENECKTL 1652
Cdd:pfam05483  589 MKILENKCNNLKKQIE-----NKNKNIEELHQENK-ALKKKGSAENKQLNAYEIKVNKLELE---LASAKQKFEEIIDNY 659

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1653 QQKVEIlgelyqqkemalqKKLTQEEYeRQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIaaHEK 1732
Cdd:pfam05483  660 QKEIED-------------KKISEEKL-LEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKII--EER 723

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2024390606 1733 KAHDNWLIARSAERALAEE--KREAANLRQKLMEVNQK 1768
Cdd:pfam05483  724 DSELGLYKNKEQEQSSAKAalEIELSNIKAELLSLKKQ 761
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1337-1773 2.12e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 59.70  E-value: 2.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1337 LSVKSRMYQVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAkeSMKVAQeqksiLSDEIAGLKDTVKELEETNHQLDD 1416
Cdd:TIGR02169  376 VDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRL--SEELAD-----LNAAIAGIEAKINELEEEKEDKAL 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1417 KIKslrtmldterkqnaKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKE 1496
Cdd:TIGR02169  449 EIK--------------KQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEE 514

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1497 QLLKEAEGwseRHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTN-----CIMQLKQLDTDSA---------SEAKDGE 1562
Cdd:TIGR02169  515 VLKASIQG---VHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDavakeAIELLKRRKAGRAtflplnkmrDERRDLS 591

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1563 GL-------------EWSTK---------------DDLANG-ELPDNEKMKTQIKQMMDASRVKTMLSLVEEDRNSLQSK 1613
Cdd:TIGR02169  592 ILsedgvigfavdlvEFDPKyepafkyvfgdtlvvEDIEAArRLMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFSRS 671

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1614 LSDEVAarhELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEIL----------GELYQQKEMALQKKLTQEEYERQE 1683
Cdd:TIGR02169  672 EPAELQ---RLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAsrkigeiekeIEQLEQEEEKLKERLEELEEDLSS 748

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1684 KEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSY--------KNQIAAHEKKAHDNWLIARSAERALAEEKREA 1755
Cdd:TIGR02169  749 LEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLshsripeiQAELSKLEEEVSRIEARLREIEQKLNRLTLEK 828

                          490
                   ....*....|....*...
gi 2024390606 1756 ANLRQKLMEVNQKTIMLQ 1773
Cdd:TIGR02169  829 EYLEKEIQELQEQRIDLK 846
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1337-1592 2.50e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 59.26  E-value: 2.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1337 LSVKSRMYQVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDD 1416
Cdd:TIGR04523  396 LESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSR 475

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1417 KIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEvqIALNESKLSEEKVKAELQHVQEENARLKK--- 1493
Cdd:TIGR04523  476 SINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISS--LKEKIEKLESEKKEKESKISDLEDELNKDdfe 553

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1494 -SKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCI----MQLKQLDTDSASEAKDGEGLEwST 1568
Cdd:TIGR04523  554 lKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIeekeKKISSLEKELEKAKKENEKLS-SI 632

                          250       260
                   ....*....|....*....|....
gi 2024390606 1569 KDDLANGElpdnEKMKTQIKQMMD 1592
Cdd:TIGR04523  633 IKNIKSKK----NKLKQEVKQIKE 652
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1600-1762 3.69e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.79  E-value: 3.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1600 LSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILG----------ELYQQKEMA 1669
Cdd:COG1196    234 LRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLaelarleqdiARLEERRRE 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1670 LQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKKAHDnwliARSAERALA 1749
Cdd:COG1196    314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE----LEELAEELL 389

                          170
                   ....*....|...
gi 2024390606 1750 EEKREAANLRQKL 1762
Cdd:COG1196    390 EALRAAAELAAQL 402
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1775-1983 4.20e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 4.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1775 PLIVKPTPGRPDRQVPPRRvplsrdgsfgPSPvsggNPSPTQMMEVPSRPLSAPQREGSRAEFGTVVD--GPPAPRRPPE 1852
Cdd:PHA03247  2554 PLPPAAPPAAPDRSVPPPR----------PAP----RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDprGPAPPSPLPP 2619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1853 LPGRMSVPDLGPAVA--SLISSGPRTSSPATAKDRAPSPKEPEAPRVTTDSPSSIEPATVNVGPKGPPSFPGTPVMTSPV 1930
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAanEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA 2699

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1931 LgppppppvnygpppapfPGHYGPGPRPLPVPLVCGAPLP--PPAARDFLPGPSL 1983
Cdd:PHA03247  2700 D-----------------PPPPPPTPEPAPHALVSATPLPpgPAAARQASPALPA 2737
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1430-1776 6.67e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 58.16  E-value: 6.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1430 KQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEEnaRLKKSKEQLLK----EAEGW 1505
Cdd:TIGR02169  149 SMSPVERRKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRRE--REKAERYQALLkekrEYEGY 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1506 serhtELTEQIKLYRKSQKDIEEALAYKENEIEVLTnciMQLKQLDTDSASEAKDGEGLEWSTKDdlangeLPDNEkmkt 1585
Cdd:TIGR02169  227 -----ELLKEKEALERQKEAIERQLASLEEELEKLT---EEISELEKRLEEIEQLLEELNKKIKD------LGEEE---- 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1586 qikqmmdASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELY-- 1663
Cdd:TIGR02169  289 -------QLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYae 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1664 -QQKEMALQKKLTQEEYERQEKEQKLSAADEKavlaIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKKAHDnwliAR 1742
Cdd:TIGR02169  362 lKEELEDLRAELEEVDKEFAETRDELKDYREK----LEKLKREINELKRELDRLQEELQRLSEELADLNAAIAG----IE 433

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 2024390606 1743 SAERALAEEKREAA----NLRQKLMEVNQKTIMLQRPL 1776
Cdd:TIGR02169  434 AKINELEEEKEDKAleikKQEWKLEQLAADLSKYEQEL 471
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1348-1755 9.34e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.54  E-value: 9.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKsiLSDEIAGLKD--------TVKELEETNHQLDDKIK 1419
Cdd:pfam12128  345 DQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQ--NNRDIAGIKDklakireaRDRQLAVAEDDLQALES 422

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1420 SLRTMLDTErKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEvQIALNESKL-----SEEKVKAELQHVQEENARLKKS 1494
Cdd:pfam12128  423 ELREQLEAG-KLEFNEEEYRLKSRLGELKLRLNQATATPELLL-QLENFDERIerareEQEAANAEVERLQSELRQARKR 500

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1495 KEQ----LLKEAEGWSERHTELTE-QIKLYRKSQKDIE----EALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLE 1565
Cdd:pfam12128  501 RDQaseaLRQASRRLEERQSALDElELQLFPQAGTLLHflrkEAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGELNL 580

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1566 WSTKDDLANGELPDNEKMKTQIKQMMDAsrvktmlslVEEDrnsLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARL 1645
Cdd:pfam12128  581 YGVKLDLKRIDVPEWAASEEELRERLDK---------AEEA---LQSAREKQAAAEEQLVQANGELEKASREETFARTAL 648

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1646 ENECKTLQQkveiLGELYQQKEMALQKKLTQEEYERQEKEQKLSAadekavlaieEVKVYKQRIQDMEEELQKTERSYKN 1725
Cdd:pfam12128  649 KNARLDLRR----LFDEKQSEKDKKNKALAERKDSANERLNSLEA----------QLKQLDKKHQAWLEEQKEQKREART 714

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2024390606 1726 QIAAHEK---KAHDNWLIARSAERALAEEKREA 1755
Cdd:pfam12128  715 EKQAYWQvveGALDAQLALLKAAIAARRSGAKA 747
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1338-1730 1.00e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.38  E-value: 1.00e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1338 SVKSRMYQVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQakesmkvaqeqksiLSDEIAGLKDTVKELEETNhqldDK 1417
Cdd:PRK03918   376 RLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGE--------------LKKEIKELKKAIEELKKAK----GK 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1418 IKSLRTMLDTERKQN--AKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESK--LSEEKVKAELQHVQEENARLKK 1493
Cdd:PRK03918   438 CPVCGRELTEEHRKEllEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESelIKLKELAEQLKELEEKLKKYNL 517

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1494 SK-EQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEAlaykENEIEVLTNcimQLKQLDTDSASEAKDGEGLEWSTKDDL 1572
Cdd:PRK03918   518 EElEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEEL----KKKLAELEK---KLDELEEELAELLKELEELGFESVEEL 590

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1573 angelpdnekmKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEvaaRHELEEQIKKLEHDSSSLQSAKARLEN-ECKT 1651
Cdd:PRK03918   591 -----------EERLKELEPFYNEYLELKDAEKELEREEKELKKL---EEELDKAFEELAETEKRLEELRKELEElEKKY 656

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1652 LQQKVEILGELYQQKEMALQKKLTQ-EEYERQEKEQKLSAADEKAVLaiEEVKVYKQRIQDME------EELQKTERSYK 1724
Cdd:PRK03918   657 SEEEYEELREEYLELSRELAGLRAElEELEKRREEIKKTLEKLKEEL--EEREKAKKELEKLEkalervEELREKVKKYK 734


                   ....*.
gi 2024390606 1725 NQIAAH 1730
Cdd:PRK03918   735 ALLKER 740
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1326-1762 1.29e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 57.25  E-value: 1.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1326 ATLAIIFWRTcLSVKSRMYQVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVK 1405
Cdd:COG1196    227 AELLLLKLRE-LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIA 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1406 ELEETNHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEafsmhsaELSEVQIALNESKLSEEKVKAELQHVQ 1485
Cdd:COG1196    306 RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEE-------ELEEAEAELAEAEEALLEAEAELAEAE 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1486 EENARLKKSKEQLLKEAEgwserhtELTEQIKLYRKSQKDIEEALAYKENEIEVLTNcimQLKQLDTDSASEAKdgegle 1565
Cdd:COG1196    379 EELEELAEELLEALRAAA-------ELAAQLEELEEAEEALLERLERLEEELEELEE---ALAELEEEEEEEEE------ 442

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1566 wsTKDDLANGELPDNEKMKTQIKQMMDASRVktmLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKArl 1645
Cdd:COG1196    443 --ALEEAAEEEAELEEEEEALLELLAELLEE---AALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALL-- 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1646 enecKTLQQKVEILGELYQQKEMALQKKLtqEEYERQEKEQKLSAADEKAVLAIEEVKvykqriqdmEEELQKTERSYKN 1725
Cdd:COG1196    516 ----LAGLRGLAGAVAVLIGVEAAYEAAL--EAALAAALQNIVVEDDEVAAAAIEYLK---------AAKAGRATFLPLD 580

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 2024390606 1726 QIAAHEKKAHDNWLIARSAERALAEEKREAANLRQKL 1762
Cdd:COG1196    581 KIRARAALAAALARGAIGAAVDLVASDLREADARYYV 617
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1342-1770 1.83e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 56.59  E-value: 1.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1342 RMYQV--TEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETN---HQLDD 1416
Cdd:TIGR00606  190 TLRQVrqTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLskiMKLDN 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1417 KIKSlrtmLDTERKQNAKKQKKLSetqkslEKFEEAFSMHSAELSEVqialnesklsEEKVKAELQHVQEENARLKKSKE 1496
Cdd:TIGR00606  270 EIKA----LKSRKKQMEKDNSELE------LKMEKVFQGTDEQLNDL----------YHNHQRTVREKERELVDCQRELE 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1497 QLLKEAEGWSERHTEL-TEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDLAN- 1574
Cdd:TIGR00606  330 KLNKERRLLNQEKTELlVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKt 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1575 -----GELPDNEKMKTQikqmmdasrvktMLSLVEEDRNSLQSKLSDEvaaRHELEEQIKKLEHDSSSLQSAKARLENEC 1649
Cdd:TIGR00606  410 aaqlcADLQSKERLKQE------------QADEIRDEKKGLGRTIELK---KEILEKKQEELKFVIKELQQLEGSSDRIL 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1650 KTLQQKVEILGELYQQKEMAL-QKKLTQEEYERQEK---EQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKN 1725
Cdd:TIGR00606  475 ELDQELRKAERELSKAEKNSLtETLKKEVKSLQNEKadlDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKI 554

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024390606 1726 QIAAHE-----------KKAHDNWLIARSAERALAEEKREAANLRQKLMEVNQKTI 1770
Cdd:TIGR00606  555 KSRHSDeltsllgyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHI 610
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1343-1595 1.95e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.60  E-value: 1.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1343 MYQVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEqksilsdEIAGLKDTVKELEETNHQLDDKIKSLR 1422
Cdd:TIGR02168  250 EAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALAN-------EISRLEQQKQILRERLANLERQLEELE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1423 TMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQllkea 1502
Cdd:TIGR02168  323 AQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIAS----- 397

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1503 egwserhteLTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDLANGELPDNEK 1582
Cdd:TIGR02168  398 ---------LNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELRE 468

                          250
                   ....*....|...
gi 2024390606 1583 MKTQIKQMMDASR 1595
Cdd:TIGR02168  469 ELEEAEQALDAAE 481
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1335-1721 2.25e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 56.52  E-value: 2.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1335 TCLSVKSRMYQVTEKQLAEKIQnLLQEKTEMLDKFSECDEKIKQAKESMKVAQ----------EQKSILSDEIAGLKDTV 1404
Cdd:TIGR00618  452 QCEKLEKIHLQESAQSLKEREQ-QLQTKEQIHLQETRKKAVVLARLLELQEEPcplcgscihpNPARQDIDNPGPLTRRM 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1405 KELEETNHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQ------IALNESKLSEEKVK 1478
Cdd:TIGR00618  531 QRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQnitvrlQDLTEKLSEAEDML 610

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1479 AELQHVQEENARLKKSKEQLLKEAEGWSERHTELT---EQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSA 1555
Cdd:TIGR00618  611 ACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLtalHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKE 690

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1556 SEAKDGEGLEWstKDDLANGELPDNEKMKTQIKQMMDA-----SRVKTMLSLVEEDRNSLQ----SKLSDEVAARHELEE 1626
Cdd:TIGR00618  691 QLTYWKEMLAQ--CQTLLRELETHIEEYDREFNEIENAssslgSDLAAREDALNQSLKELMhqarTVLKARTEAHFNNNE 768

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1627 QIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQKEMAL----QKKLTQEEYERQEKEQKLSAADEKAVLAIE-- 1700
Cdd:TIGR00618  769 EVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIpsdeDILNLQCETLVQEEEQFLSRLEEKSATLGEit 848

                          410       420
                   ....*....|....*....|..
gi 2024390606 1701 -EVKVYKQRIQDMEEELQKTER 1721
Cdd:TIGR00618  849 hQLLKYEECSKQLAQLTQEQAK 870
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1603-1764 3.38e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.83  E-value: 3.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1603 VEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILG---ELYQQKEMALQKKLTQEEY 1679
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEqqkQILRERLANLERQLEELEA 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1680 ERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKKahDNWLIARSAERALAEEKREAANLR 1759
Cdd:TIGR02168  324 QLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL--EEQLETLRSKVAQLELQIASLNNE 401


                   ....*
gi 2024390606 1760 QKLME 1764
Cdd:TIGR02168  402 IERLE 406
SH3_2 pfam07653
Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in ...
 108-163 6.40e-07

Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 429575 [Multi-domain]  Cd Length: 54  Bit Score: 47.98  E-value: 6.40e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024390606  108 RGKAMKDFQGPDCRFVNFKKGETVYVYYKLIGmstELWAGSIGSDFGYFPKDLLEI 163
Cdd:pfam07653    1 YGRVIFDYVGTDKNGLTLKKGDVVKVLGKDND---GWWEGETGGRVGLVPSTAVEE 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1780-1981 1.05e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1780 PTPGRPDRQVPPRRVPLSRD-GSFGPSPVSGGNPSPTQMMEVPSRPLSAPQREGSRAEFGTVVDGPP-APRRPPELPGRM 1857
Cdd:PHA03247  2614 PSPLPPDTHAPDPPPPSPSPaANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqRPRRRAARPTVG 2693

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1858 SVPDLG----------PAVASLISSGPRTSSPATAKDRAPSPKEPEAPRVTTDSPSSiePATVN-----VGPKGPPS--F 1920
Cdd:PHA03247  2694 SLTSLAdpppppptpePAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT--PGGPArparpPTTAGPPApaP 2771

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024390606 1921 PGTPVMT-SPVLGPPPPPPVNYGPPPAPFPghygPGPRPLPVPLVCGAPLPPPAARDFLPGP 1981
Cdd:PHA03247  2772 PAAPAAGpPRRLTRPAVASLSESRESLPSP----WDPADPPAAVLAPAAALPPAASPAGPLP 2829
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1373-1760 1.39e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.77  E-value: 1.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1373 DEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLD-DKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEE 1451
Cdd:COG4913    294 EAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEALLAALGL 373

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1452 AFSMHSAELSEVQIALNESKlseEKVKAELQHVQEENARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQ----KDIE 1527
Cdd:COG4913    374 PLPASAEEFAALRAEAAALL---EALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLlalrDALA 450

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1528 EALAYKENEIEVLtnC-IMQLKQLD------------------------TDSASEA----KDGEGLEW----STKDDLAN 1574
Cdd:COG4913    451 EALGLDEAELPFV--GeLIEVRPEEerwrgaiervlggfaltllvppehYAAALRWvnrlHLRGRLVYervrTGLPDPER 528

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1575 GELPDN---EKMKT-----------QIKQMMDASRVKTmlslVEE------------------------DRNSLQSKL-- 1614
Cdd:COG4913    529 PRLDPDslaGKLDFkphpfrawleaELGRRFDYVCVDS----PEElrrhpraitragqvkgngtrhekdDRRRIRSRYvl 604

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1615 -SDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYERQEKE-QKLSAAD 1692
Cdd:COG4913    605 gFDNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAElERLDASS 684

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1693 EKAVLAIEEVKVYKQRIQDMEEELQKTERSY---KNQIAAHEK-------KAHDNWLIARSAERALAEEKREAANLRQ 1760
Cdd:COG4913    685 DDLAALEEQLEELEAELEELEEELDELKGEIgrlEKELEQAEEeldelqdRLEAAEDLARLELRALLEERFAAALGDA 762
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1401-1768 1.47e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.77  E-value: 1.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1401 KDTVKELEETNHQLDDkIKSLRTMLDTERKQnakkQKKLSETQKSLEKFEEAF---SMHSAELSEVQIALNESKLseEKV 1477
Cdd:COG4913    221 PDTFEAADALVEHFDD-LERAHEALEDAREQ----IELLEPIRELAERYAAARerlAELEYLRAALRLWFAQRRL--ELL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1478 KAELQHVQEENARLKKSKEQLLKEAEGWSERHTELTEQIklyRKSQKDIEEALaykENEIEVLTNcimQLKQLDTDSASE 1557
Cdd:COG4913    294 EAELEELRAELARLEAELERLEARLDALREELDELEAQI---RGNGGDRLEQL---EREIERLER---ELEERERRRARL 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1558 AKDGEGLEWSTKDDLAngelpDNEKMKTQIKQMMDAsrVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSS 1637
Cdd:COG4913    365 EALLAALGLPLPASAE-----EFAALRAEAAALLEA--LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSN 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1638 ----LQSAKARLENECKTLQQKVEILGELYQQKE------------------------------------MALQKKLTQE 1677
Cdd:COG4913    438 iparLLALRDALAEALGLDEAELPFVGELIEVRPeeerwrgaiervlggfaltllvppehyaaalrwvnrLHLRGRLVYE 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1678 EYERQEKEQKLSAADEKAV---LAIEEVKVY---KQRIQ--------DMEEELQKTERS------YKNQIAAHEKKAHD- 1736
Cdd:COG4913    518 RVRTGLPDPERPRLDPDSLagkLDFKPHPFRawlEAELGrrfdyvcvDSPEELRRHPRAitragqVKGNGTRHEKDDRRr 597

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2024390606 1737 ---NWLIARSAERALAEEKREAANLRQKLMEVNQK 1768
Cdd:COG4913    598 irsRYVLGFDNRAKLAALEAELAELEEELAEAEER 632
PTZ00121 PTZ00121
MAEBL; Provisional
 1356-1768 1.80e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 1.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1356 QNLLQEKTEMLDKFSECDEKIKQA------KESMKVAQEQKSILSDEIAGLKDTVKELEET---NHQLDDKIKSLRTMLD 1426
Cdd:PTZ00121  1022 QNFNIEKIEELTEYGNNDDVLKEKdiidedIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDakeDNRADEATEEAFGKAE 1101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1427 TERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKS-KEQLLKEAEgw 1505
Cdd:PTZ00121  1102 EAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEArKAEDAKKAE-- 1179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1506 SERHTELTEQIKLYRKSQ--KDIEEALAYKE-NEIEVLTncimqlKQLDTDSASEAKDGEGLEWSTKDDLANGELPDNEK 1582
Cdd:PTZ00121  1180 AARKAEEVRKAEELRKAEdaRKAEAARKAEEeRKAEEAR------KAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEE 1253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1583 MKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGEL 1662
Cdd:PTZ00121  1254 IRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADA 1333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1663 YQQKEMALQKKLTQEEYERQEKEQKLSAADEKA---VLAIEEVKVYKQRIQDMEEELQKTERSYKNqiaAHEKKAHDNWL 1739
Cdd:PTZ00121  1334 AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAeaaEKKKEEAKKKADAAKKKAEEKKKADEAKKK---AEEDKKKADEL 1410

                          410       420
                   ....*....|....*....|....*....
gi 2024390606 1740 IARSAERALAEEKREAANLRQKLMEVNQK 1768
Cdd:PTZ00121  1411 KKAAAAKKKADEAKKKAEEKKKADEAKKK 1439
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1780-2072 2.12e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 2.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1780 PTPGRPDRQVPPRRVPLSRDGSFGPSPVSggnpsptqmmevPSRPLSAPQREGSRAEFGTVVD--GPPAPRRPPELPGRM 1857
Cdd:PHA03247  2647 PPPERPRDDPAPGRVSRPRRARRLGRAAQ------------ASSPPQRPRRRAARPTVGSLTSlaDPPPPPPTPEPAPHA 2714

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1858 SVPDLGpavASLISSGPRTSSPATAKDRAP-----------SPKEPEAPRVTTDSPSSIEPATVNVGPkgPPSFPGTPVM 1926
Cdd:PHA03247  2715 LVSATP---LPPGPAAARQASPALPAAPAPpavpagpatpgGPARPARPPTTAGPPAPAPPAAPAAGP--PRRLTRPAVA 2789

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1927 TSPVLGPPPPPPVNYGPPPAPFPG-----HYGPGPRPLPVPLVCGAPLPPPAARDFLPgPSLGIrdlppgplpplpdPRS 2001
Cdd:PHA03247  2790 SLSESRESLPSPWDPADPPAAVLApaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP-PSLPL-------------GGS 2855

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 2002 YRRGHPhFRPPGPPGPRDYPPGPPLPPPASRDYAPSRSRD-----LPPAGPRDYP--AGPAPPPAGSKDYAQPPVQKP 2072
Cdd:PHA03247  2856 VAPGGD-VRRRPPSRSPAAKPAAPARPPVRRLARPAVSRStesfaLPPDQPERPPqpQAPPPPQPQPQPPPPPQPQPP 2932
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1343-1767 2.23e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.80  E-value: 2.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1343 MYQVTEKQlaEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIK-SL 1421
Cdd:pfam05483  246 LIQITEKE--NKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQiAT 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1422 RTMLD-TERKqnakkqkklsETQksLEKFEEAFSMHSAELSEVQIALNESklsEEKVKAELQhvqeenaRLKKSKEQLLK 1500
Cdd:pfam05483  324 KTICQlTEEK----------EAQ--MEELNKAKAAHSFVVTEFEATTCSL---EELLRTEQQ-------RLEKNEDQLKI 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1501 EAEGWSERHTELTEQIKLYRKSQKDIEEaLAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDLANGEL--- 1577
Cdd:pfam05483  382 ITMELQKKSSELEEMTKFKNNKEVELEE-LKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIqlt 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1578 ---PDNEKMKTQIKQM---MDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEeqIKKLEHDSSSLQSAKARLENECKT 1651
Cdd:pfam05483  461 aikTSEEHYLKEVEDLkteLEKEKLKNIELTAHCDKLLLENKELTQEASDMTLE--LKKHQEDIINCKKQEERMLKQIEN 538

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1652 LQQK-------VEILGELYQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDME---EELQKTER 1721
Cdd:pfam05483  539 LEEKemnlrdeLESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNkniEELHQENK 618

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 2024390606 1722 SYKNQIAAHEKKAHDNWLIARSAERALAEEKR---EAANLRQKLMEVNQ 1767
Cdd:pfam05483  619 ALKKKGSAENKQLNAYEIKVNKLELELASAKQkfeEIIDNYQKEIEDKK 667
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1375-1792 2.93e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 52.77  E-value: 2.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1375 KIKQAKESMKVAQEQksilsdeIAGLKdTVKELE-ETNHQLDDKIK-SLRTMLDTER-----KQNAKKQKKLSETQKSLE 1447
Cdd:COG5022    763 RYLQALKRIKKIQVI-------QHGFR-LRRLVDyELKWRLFIKLQpLLSLLGSRKEyrsylACIIKLQKTIKREKKLRE 834

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1448 KFEEAFSMHSAELSE--VQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKD 1525
Cdd:COG5022    835 TEEVEFSLKAEVLIQkfGRSLKAKKRFSLLKKETIYLQSAQRVELAERQLQELKIDVKSISSLKLVNLELESEIIELKKS 914

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1526 IEEALAykeNEIEVLTNCIMQLKQLdtDSASEAKDGEGLEWSTKDDLaNGELPDNEKMKTQIKQMMDA--------SRVK 1597
Cdd:COG5022    915 LSSDLI---ENLEFKTELIARLKKL--LNNIDLEEGPSIEYVKLPEL-NKLHEVESKLKETSEEYEDLlkkstilvREGN 988

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1598 TMLSLVEEDRNSLQSkLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQ-----QKVEILGELyqqKEMALQK 1672
Cdd:COG5022    989 KANSELKNFKKELAE-LSKQYGALQESTKQLKELPVEVAELQSASKIISSESTELSilkplQKLKGLLLL---ENNQLQA 1064

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1673 KLTQEEYERqekeqKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKT----ERSYKNQIAAHEKKAHDNWLIARSAERAL 1748
Cdd:COG5022   1065 RYKALKLRR-----ENSLLDDKQLYQLESTENLLKTINVKDLEVTNRnlvkPANVLQFIVAQMIKLNLLQEISKFLSQLV 1139

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2024390606 1749 AEEKREAANLRQKLMEVnqKTIMLQRPLIVKPTPGRPDRQVPPR 1792
Cdd:COG5022   1140 NTLEPVFQKLSVLQLEL--DGLFWEANLEALPSPPPFAALSEKR 1181
Taxilin pfam09728
Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain ...
 1341-1654 3.04e-06

Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.


Pssm-ID: 462861 [Multi-domain]  Cd Length: 302  Bit Score: 51.49  E-value: 3.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1341 SRMYQVTEKQLAEKIQNLLQEKTEMLDKFSE-----------CDEKIKQAK----ESMKVAQEQKSILSDEIAGLKDTVK 1405
Cdd:pfam09728   34 MKRLQKDLKKLKKKQDQLQKEKDQLQSELSKailakskleklCRELQKQNKklkeESKKLAKEEEEKRKELSEKFQSTLK 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1406 ELEET-NHQLDDKIKSlrtmldteRKQNAKKQKKLSETQKSLEKFEEAF-SMHsaELSEVQIALNESKLSEEKVKAELQH 1483
Cdd:pfam09728  114 DIQDKmEEKSEKNNKL--------REENEELREKLKSLIEQYELRELHFeKLL--KTKELEVQLAEAKLQQATEEEEKKA 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1484 VQEENARLKKSKEQLlkeaEGWSERHTELTEQIKLYRKSQKDIEEALA--------YKeNEIEVLTNCIMQLKQldtdsa 1555
Cdd:pfam09728  184 QEKEVAKARELKAQV----QTLSETEKELREQLNLYVEKFEEFQDTLNksnevfttFK-KEMEKMSKKIKKLEK------ 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1556 seakdgEGLEWSTKDDLANgelpdnekmktqikqmmdasrvKTMLSLVEEDRNSLQsklsdevaarhELEEQIKKLEhds 1635
Cdd:pfam09728  253 ------ENLTWKRKWEKSN----------------------KALLEMAEERQKLKE-----------ELEKLQKKLE--- 290

                          330
                   ....*....|....*....
gi 2024390606 1636 sslqsakaRLENECKTLQQ 1654
Cdd:pfam09728  291 --------KLENLCRALQA 301
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1441-1784 3.30e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.67  E-value: 3.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1441 ETQKSLEKFEEAfsmhsAELSEVQIALNESKLSEEKVKAelqhvQEENARLKKSKEQLLKEAEGW---------SERHTE 1511
Cdd:pfam02463  171 KKEALKKLIEET-----ENLAELIIDLEELKLQELKLKE-----QAKKALEYYQLKEKLELEEEYllyldylklNEERID 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1512 LTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIM------------QLKQLDTDSASEAKDGEGLEWSTKDDLANGELPD 1579
Cdd:pfam02463  241 LLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENkeeekekklqeeELKLLAKEEEELKSELLKLERRKVDDEEKLKESE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1580 NEKMKTQIKQMMDasrvktmLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEIL 1659
Cdd:pfam02463  321 KEKKKAEKELKKE-------KEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLK 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1660 GELYQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKV--YKQRIQDMEEELQKTERSYKNQIAAHEKKAHDN 1737
Cdd:pfam02463  394 EEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESieLKQGKLTEEKEELEKQELKLLKDELELKKSEDL 473

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 2024390606 1738 WLIARSAERalaEEKREAANLRQKLMEVNQKTIMLQRPLIVKPTPGR 1784
Cdd:pfam02463  474 LKETQLVKL---QEQLELLLSRQKLEERSQKESKARSGLKVLLALIK 517
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1349-1752 3.99e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 52.43  E-value: 3.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEK----TEMLDKFSECDEKIKQAKESMKVAQEQ----KSILSDEIAGLKDTVK----ELEETNHQLDD 1416
Cdd:pfam15921  263 QQHQDRIEQLISEHeveiTGLTEKASSARSQANSIQSQLEIIQEQarnqNSMYMRQLSDLESTVSqlrsELREAKRMYED 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1417 KIKSLRTML----------DTERKQNAKKQKKLSET-QK---SLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQ 1482
Cdd:pfam15921  343 KIEELEKQLvlanselteaRTERDQFSQESGNLDDQlQKllaDLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELD 422

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1483 HVQEENARLKKSKEQLLKEAEGWSERH--------------TELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLK 1548
Cdd:pfam15921  423 DRNMEVQRLEALLKAMKSECQGQMERQmaaiqgkneslekvSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLT 502

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1549 Q--LDTDSASEAKDGEGLEWSTKDDLANGELpdnEKMKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEE 1626
Cdd:pfam15921  503 AslQEKERAIEATNAEITKLRSRVDLKLQEL---QHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVG 579

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1627 QIKKlehDSSSLQSAKARLENECKTLQ---QKVEILGELYQQKEMALQKKLTQEEYER-------QEKEQKLSAADEKAV 1696
Cdd:pfam15921  580 QHGR---TAGAMQVEKAQLEKEINDRRlelQEFKILKDKKDAKIRELEARVSDLELEKvklvnagSERLRAVKDIKQERD 656

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024390606 1697 LAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKKAHDNWLIARSAERALAEEK 1752
Cdd:pfam15921  657 QLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTR 712
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1345-1756 4.25e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 52.28  E-value: 4.25e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1345 QVTEKQLAEKIQNLLQEKtEMLDKFSECDEKIKQAKESMKVAQEQKSilsdEIAGLKDTVKELEETNHQLDDKIKSLRTM 1424
Cdd:TIGR00618  222 QVLEKELKHLREALQQTQ-QSHAYLTQKREAQEEQLKKQQLLKQLRA----RIEELRAQEAVLEETQERINRARKAAPLA 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1425 LDTER--KQNAKKQKKLSETQKSLEKFEEAFsMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEA 1502
Cdd:TIGR00618  297 AHIKAvtQIEQQAQRIHTELQSKMRSRAKLL-MKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQH 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1503 E------GWSERHTELTEQIKLYRK-----------------SQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAK 1559
Cdd:TIGR00618  376 TltqhihTLQQQKTTLTQKLQSLCKeldilqreqatidtrtsAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEK 455

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1560 DGEGLEWSTKDDLAngELPDNEKMKTQIKQMMD---ASRVKTMLSLVEEDRNSLQSKLSDEVAA---------------- 1620
Cdd:TIGR00618  456 LEKIHLQESAQSLK--EREQQLQTKEQIHLQETrkkAVVLARLLELQEEPCPLCGSCIHPNPARqdidnpgpltrrmqrg 533

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1621 ---RHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQKEMALQkKLTQEEYERQEKEQKLSAADEKAVL 1697
Cdd:TIGR00618  534 eqtYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIP-NLQNITVRLQDLTEKLSEAEDMLAC 612

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024390606 1698 AIEEVKVYKQRIQDMEEELQktersYKNQIAAHEKKAHDNwlIARSAERALAEEKREAA 1756
Cdd:TIGR00618  613 EQHALLRKLQPEQDLQDVRL-----HLQQCSQELALKLTA--LHALQLTLTQERVREHA 664
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1452-1695 7.28e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 50.60  E-value: 7.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1452 AFSMHSAELSEVQIALNESKLSEekVKAELQHVQEENARLKKSKEQLLKEAEGWSERHTELTEQIKlyrKSQKDIEEAla 1531
Cdd:COG3883      5 ALAAPTPAFADPQIQAKQKELSE--LQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEID---KLQAEIAEA-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1532 ykENEIEVLTncimqlKQLDTDSASEAKDGEGLewSTKDDLANGELPDN--EKMkTQIKQMMDASR-----VKTMLSLVE 1604
Cdd:COG3883     78 --EAEIEERR------EELGERARALYRSGGSV--SYLDVLLGSESFSDflDRL-SALSKIADADAdlleeLKADKAELE 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1605 EDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYERQEK 1684
Cdd:COG3883    147 AKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAA 226

                          250
                   ....*....|.
gi 2024390606 1685 EQKLSAADEKA 1695
Cdd:COG3883    227 AAAAAAAAAAA 237
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1341-1733 7.90e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 51.20  E-value: 7.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1341 SRMYQVTEKQLAEKIQNLLQEKTEMLdkfsECDEKIKQAKESM--KVAQEQKSI---------LSDEIAGLKDTVKELEE 1409
Cdd:TIGR00606  208 ELKYLKQYKEKACEIRDQITSKEAQL----ESSREIVKSYENEldPLKNRLKEIehnlskimkLDNEIKALKSRKKQMEK 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1410 TNHQLDDKI--------KSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVqialnESKLSEEKVKAEL 1481
Cdd:TIGR00606  284 DNSELELKMekvfqgtdEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTEL-----LVEQGRLQLQADR 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1482 QHVQEENARLKKSKEQLLKEAEGWsERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDG 1561
Cdd:TIGR00606  359 HQEHIRARDSLIQSLATRLELDGF-ERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKG 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1562 EGLEWSTKDDLANGELPDNEKMKTQIKQMMDASrvKTMLSLVEEDRNSLQS-KLSDEVAARHELEEQIKKLEHDSSSLQS 1640
Cdd:TIGR00606  438 LGRTIELKKEILEKKQEELKFVIKELQQLEGSS--DRILELDQELRKAERElSKAEKNSLTETLKKEVKSLQNEKADLDR 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1641 AKARLENECKTLQQKVEILgelyQQKEMALQKKLTQEEYERQEKEQklsAADEKAVLA----------------IEEVKV 1704
Cdd:TIGR00606  516 KLRKLDQEMEQLNHHTTTR----TQMEMLTKDKMDKDEQIRKIKSR---HSDELTSLLgyfpnkkqledwlhskSKEINQ 588

                          410       420
                   ....*....|....*....|....*....
gi 2024390606 1705 YKQRIQDMEEELQKTERSyKNQIAAHEKK 1733
Cdd:TIGR00606  589 TRDRLAKLNKELASLEQN-KNHINNELES 616
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1352-1631 8.81e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.07  E-value: 8.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1352 AEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILS----------------DEIAGLKDTVKELEETNH--- 1412
Cdd:COG4913    609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQrlaeyswdeidvasaeREIAELEAELERLDASSDdla 688

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1413 QLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEafsmhsaELSEVQIALNEsklseekvkAELQHVQEENARLK 1492
Cdd:COG4913    689 ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEE-------ELDELQDRLEA---------AEDLARLELRALLE 752

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1493 KSKEQLLKEaegwsERHTELTEQIklyRKSQKDIEEALAYKENEIEvltNCIMQLKQLDTDSASEAKDG-----EGLEWS 1567
Cdd:COG4913    753 ERFAAALGD-----AVERELRENL---EERIDALRARLNRAEEELE---RAMRAFNREWPAETADLDADleslpEYLALL 821

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1568 TKddLANGELPDNE-KMKTQIKQMMdasrvktmlslvEEDRNSLQSKLSDEvaaRHELEEQIKKL 1631
Cdd:COG4913    822 DR--LEEDGLPEYEeRFKELLNENS------------IEFVADLLSKLRRA---IREIKERIDPL 869
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 1790-1981 8.83e-06

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 47.94  E-value: 8.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1790 PPrrvPLSRDGSFGPSPVSGGNPSPTQMMEVPSRPlSAPQREGSRAEfgtvvdgPPaprrPPELPGRMSVPdlgpavasl 1869
Cdd:pfam06346    3 PP---PLPGDSSTIPLPPGACIPTPPPLPGGGGPP-PPPPLPGSAAI-------PP----PPPLPGGTSIP--------- 58

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1870 issgprtsSPATAKDRAPSPKEPEAPRVTTDSPSSIEPATVNVGPKgPPSFPGTPVMTSPVlgppppppvnygpppAPFP 1949
Cdd:pfam06346   59 --------PPPPLPGAASIPPPPPLPGSTGIPPPPPLPGGAGIPPP-PPPLPGGAGVPPPP---------------PPLP 114

                          170       180       190
                   ....*....|....*....|....*....|...
gi 2024390606 1950 GhyGPG-PRPLPVPLVCGAPlPPPaardflPGP 1981
Cdd:pfam06346  115 G--GPGiPPPPPFPGGPGIP-PPP------PGM 138
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1364-1767 1.05e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 50.91  E-value: 1.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1364 EMLDKFSEcDEKIKQAKESMKVAQEQKSILSDeiaGLKDTVKELEETNHQLDDKIKSLRTMLDTERKQNAKKQK------ 1437
Cdd:pfam07111  128 EMVRKNLE-EGSQRELEEIQRLHQEQLSSLTQ---AHEEALSSLTSKAEGLEKSLNSLETKRAGEAKQLAEAQKeaellr 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1438 -KLSETQKSLE---KFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEGWSE----RH 1509
Cdd:pfam07111  204 kQLSKTQEELEaqvTLVESLRKYVGEQVPPEVHSQTWELERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHmlalQE 283

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1510 TELTEQIK----------------LYRKSQKDIEEALAYKENEIE---VLTNCIMQLKQLDTDSASEAKDGEGLEWSTKD 1570
Cdd:pfam07111  284 EELTRKIQpsdslepefpkkcrslLNRWREKVFALMVQLKAQDLEhrdSVKQLRGQVAELQEQVTSQSQEQAILQRALQD 363

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1571 DLANGELpdnEKMKTQIKQMmDASRVKTMLSLVEEDRNSLQSKLSDEVAA----RHELEEQIKKLEHDSSSLQSAKARLE 1646
Cdd:pfam07111  364 KAAEVEV---ERMSAKGLQM-ELSRAQEARRRQQQQTASAEEQLKFVVNAmsstQIWLETTMTRVEQAVARIPSLSNRLS 439

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1647 ------NECKTLQQKVEILGELYQQK------------EMALQKKLTQEEYERQEKEQKLSA--ADEKAVLAIEEVKVYK 1706
Cdd:pfam07111  440 yavrkvHTIKGLMARKVALAQLRQEScpppppappvdaDLSLELEQLREERNRLDAELQLSAhlIQQEVGRAREQGEAER 519

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1707 QRI----QDMEEELQKTERSYKNQIAAHEkkahdnwliarSAERALAEEKREAANLRQKLMEVNQ 1767
Cdd:pfam07111  520 QQLsevaQQLEQELQRAQESLASVGQQLE-----------VARQGQQESTEEAASLRQELTQQQE 573
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1351-1764 1.05e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 50.94  E-value: 1.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1351 LAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERK 1430
Cdd:pfam01576  143 LEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQE 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1431 QNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEE-------NARLKKSKEQLLKEAE 1503
Cdd:pfam01576  223 QIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDleseraaRNKAEKQRRDLGEELE 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1504 GW------------------SERHTELTEQIKLYRKSQKDIEEALA-YKENEIEVLTNCIMQLKQLDTDSASEAKDGEGL 1564
Cdd:pfam01576  303 ALkteledtldttaaqqelrSKREQEVTELKKALEEETRSHEAQLQeMRQKHTQALEELTEQLEQAKRNKANLEKAKQAL 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1565 EWStkddlaNGELPDNEKMKTQIKQMMDASRVKtmlslVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKAR 1644
Cdd:pfam01576  383 ESE------NAELQAELRTLQQAKQDSEHKRKK-----LEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNE 451

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1645 LENECKTLQQKVEILGELYQQKEMALQkkltqeeyerQEKEQKLSAADEkaVLAIEEVKVYKQRIQDMEEE----LQKTE 1720
Cdd:pfam01576  452 AEGKNIKLSKDVSSLESQLQDTQELLQ----------EETRQKLNLSTR--LRQLEDERNSLQEQLEEEEEakrnVERQL 519

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2024390606 1721 RSYKNQIAAHEKKAHDNWLIARSAERALAEEKREAANLRQKLME 1764
Cdd:pfam01576  520 STLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEE 563
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1573-1809 1.09e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 1.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1573 ANGELPDNEKMKTQIKQMMDASRVKtmLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTL 1652
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKE--LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1653 QQKVEILGELYQQKEMALQKK---------LTQEE----YERQEKEQKLSAADEKavlAIEEVKVYKQRIQDMEEELQKT 1719
Cdd:COG4942     96 RAELEAQKEELAELLRALYRLgrqpplallLSPEDfldaVRRLQYLKYLAPARRE---QAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1720 ERSYKNQIAAHEKKAHDNWLIARSAERALAEEKREAANLRQKLMEVNQKTIMLQRpLIVKPTPGRPDRQVPPRRVPLSRD 1799
Cdd:COG4942    173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEA-LIARLEAEAAAAAERTPAAGFAAL 251

                          250
                   ....*....|
gi 2024390606 1800 GSFGPSPVSG 1809
Cdd:COG4942    252 KGKLPWPVSG 261
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1373-1562 1.17e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.83  E-value: 1.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1373 DEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEA 1452
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1453 FSMHSAELSEVQIALNESKLSE------------EKVKAELQHVQEENARLKKSKEQLLKEAEgwserhtELTEQIKLYR 1520
Cdd:COG3883     95 LYRSGGSVSYLDVLLGSESFSDfldrlsalskiaDADADLLEELKADKAELEAKKAELEAKLA-------ELEALKAELE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2024390606 1521 KSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGE 1562
Cdd:COG3883    168 AAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAE 209
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 1393-1756 1.22e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 50.07  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1393 LSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKL 1472
Cdd:pfam19220   39 ILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLAKLEAALREAEAAKEELRIELRDKTA 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1473 SEEKVKAEL-------QHVQEENARLK---KSKEQLLKEAEGwsERhTELTEQIKLY----RKSQKDIEEALAykenEIE 1538
Cdd:pfam19220  119 QAEALERQLaaeteqnRALEEENKALReeaQAAEKALQRAEG--EL-ATARERLALLeqenRRLQALSEEQAA----ELA 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1539 VLTNCIMQLKQLDTDSASEAKDGEGlewstkdDLANgELPDNEKMKTQIKQMMDASRVktmlslveeDRNSLQSKLsDEV 1618
Cdd:pfam19220  192 ELTRRLAELETQLDATRARLRALEG-------QLAA-EQAERERAEAQLEEAVEAHRA---------ERASLRMKL-EAL 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1619 AARH---------------ELEEQIKKLEHDSSSLQSAKARLENECKTLQQkveilgELYQQKEMALQ-KKLTQEEYERQ 1682
Cdd:pfam19220  254 TARAaateqllaearnqlrDRDEAIRAAERRLKEASIERDTLERRLAGLEA------DLERRTQQFQEmQRARAELEERA 327

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024390606 1683 EKEQKLSAADEKAVLAIEEvkvykqRIQDMEEELQKTERSYKNQIAAHEKKAHD--NWLIARSAERALAEEKREAA 1756
Cdd:pfam19220  328 EMLTKALAAKDAALERAEE------RIASLSDRIAELTKRFEVERAALEQANRRlkEELQRERAERALAQGALEIA 397
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1352-1530 1.45e-05

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 50.22  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1352 AEKIQNLLQEKTEMLDK---FSECD-EKIKQAKESMKVAQEQKSILSDEIAG-------LKDTVKELEETNHQLDDKIKS 1420
Cdd:PRK04778   322 AKEQNKELKEEIDRVKQsytLNESElESVRQLEKQLESLEKQYDEITERIAEqeiayseLQEELEEILKQLEEIEKEQEK 401

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1421 LRTMLDTERK--QNAKK-----QKKLSETQKSLEK---------FEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHV 1484
Cdd:PRK04778   402 LSEMLQGLRKdeLEAREkleryRNKLHEIKRYLEKsnlpglpedYLEMFFEVSDEIEALAEELEEKPINMEAVNRLLEEA 481

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1485 QEENARLKKSKEQLLKEAegwserhtELTEQI----KLYRKSQKDIEEAL 1530
Cdd:PRK04778   482 TEDVETLEEETEELVENA--------TLTEQLiqyaNRYRSDNEEVAEAL 523
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1344-1762 1.76e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 50.07  E-value: 1.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1344 YQVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLD-------- 1415
Cdd:TIGR02169  348 ERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSeeladlna 427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1416 ------DKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENA 1489
Cdd:TIGR02169  428 aiagieAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVR 507

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1490 RLKKSKEQLLKEAEGwseRHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTN-----CIMQLKQLDTDSA--------- 1555
Cdd:TIGR02169  508 GGRAVEEVLKASIQG---VHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDavakeAIELLKRRKAGRAtflplnkmr 584

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1556 SEAKDGEGL-------------EWSTK---------------DDLANG-ELPDNEKMKTQIKQMMDASRVKTMLSLVEED 1606
Cdd:TIGR02169  585 DERRDLSILsedgvigfavdlvEFDPKyepafkyvfgdtlvvEDIEAArRLMGKYRMVTLEGELFEKSGAMTGGSRAPRG 664

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1607 RNSLQSKLSDEVAarhELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEIL----------GELYQQKEMALQKKLTQ 1676
Cdd:TIGR02169  665 GILFSRSEPAELQ---RLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAsrkigeiekeIEQLEQEEEKLKERLEE 741

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1677 EEYERQEKEQKLSAADEK--------------------------AVLAIEEVKVYKQRIQDMEEELQKTE---------- 1720
Cdd:TIGR02169  742 LEEDLSSLEQEIENVKSElkelearieeleedlhkleealndleARLSHSRIPEIQAELSKLEEEVSRIEarlreieqkl 821

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024390606 1721 ---------------------RSYKNQIAAHEKKAHDNWLIARSAERALAEEKREAANLRQKL 1762
Cdd:TIGR02169  822 nrltlekeylekeiqelqeqrIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRL 884
PHA03379 PHA03379
EBNA-3A; Provisional
 1779-1917 1.92e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 50.06  E-value: 1.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1779 KPTPG--RPDRQVPPRRVPLSRDGSFGPSPVSGGNPSPTQMMEvpsrplSAPQREGSRAEFGTVVDGPPAPRRPPE---- 1852
Cdd:PHA03379   410 EPTYGtpRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLE------PGPLHDQHSMAPCPVAQLPPGPLQDLEpgdq 483

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024390606 1853 LPGRMSVPDLGPAVASLISSG---PRTSSPATAKDRAPSPKEPE------APRVTTDSPSSIEPATVNVGPKGP 1917
Cdd:PHA03379   484 LPGVVQDGRPACAPVPAPAGPivrPWEASLSQVPGVAFAPVMPQpmpvepVPVPTVALERPVCPAPPLIAMQGP 557
ADIP pfam11559
Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at ...
 1608-1718 2.21e-05

Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at cell-cell adherens junctions, and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins localized at Cell-Cell Adherens Junctions.


Pssm-ID: 463295 [Multi-domain]  Cd Length: 151  Bit Score: 46.54  E-value: 2.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1608 NSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVeilgELYQQKEMALQKKL-TQEEYERQEKE- 1685
Cdd:pfam11559   41 YELLQQRDRDLEFRESLNETIRTLEAEIERLQSKIERLKTQLEDLEREL----ALLQAKERQLEKKLkTLEQKLKNEKEe 116

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024390606 1686 -QKL-SAADEKAVLAIEEVKVYKQRIQDMEEELQK 1718
Cdd:pfam11559  117 lQRLkNALQQIKTQFAHEVKKRDREIEKLKERLAQ 151
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1376-1528 2.86e-05

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 49.44  E-value: 2.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1376 IKQAKESMkvaQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKslrtmlDTERKQNAKKQKKlsetqkslEKFEEAF-- 1453
Cdd:PRK00409   504 IEEAKKLI---GEDKEKLNELIASLEELERELEQKAEEAEALLK------EAEKLKEELEEKK--------EKLQEEEdk 566

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1454 SMHSAElSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEqlLKEAegwserHTELTEQIKLYRKSQKDIEE 1528
Cdd:PRK00409   567 LLEEAE-KEAQQAIKEAKKEADEIIKELRQLQKGGYASVKAHE--LIEA------RKRLNKANEKKEKKKKKQKE 632
PRK11637 PRK11637
AmiB activator; Provisional
 1625-1768 2.99e-05

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 48.92  E-value: 2.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1625 EEQIKKLEHDSSSLQSAKARLENecKTLQQKvEILGELYQQkemalQKKLTQEEYERQEKEQKLSAADEKAvlaieevkv 1704
Cdd:PRK11637   169 QETIAELKQTREELAAQKAELEE--KQSQQK-TLLYEQQAQ-----QQKLEQARNERKKTLTGLESSLQKD--------- 231

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024390606 1705 ykqriQDMEEELQKTERSYKNQIAAHEKKAHdnwliARsAERalaeEKREAANLRQKLMEVNQK 1768
Cdd:PRK11637   232 -----QQQLSELRANESRLRDSIARAEREAK-----AR-AER----EAREAARVRDKQKQAKRK 280
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1351-1667 3.11e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 49.27  E-value: 3.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1351 LAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIA--------------GLKDTVKELEETNHQLDD 1416
Cdd:PRK02224   347 LREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEelrerfgdapvdlgNAEDFLEELREERDELRE 426

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1417 KIKSLRTMLDTERKQNAKKQKKL--------------SETQKSLEKFEEAFSMHSAELSEVQIALNE------------- 1469
Cdd:PRK02224   427 REAELEATLRTARERVEEAEALLeagkcpecgqpvegSPHVETIEEDRERVEELEAELEDLEEEVEEveerleraedlve 506

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1470 -----------SKLSEEKV---KAELQHVQEENARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKEN 1535
Cdd:PRK02224   507 aedrierleerREDLEELIaerRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKE 586

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1536 EIEvltncimQLKQLDTDSASEAKDGEGLEWSTKDDLANGELPDNEKMKTQIKQmmdaSRVKTMLSLVEEDR-NSLQSKL 1614
Cdd:PRK02224   587 RIE-------SLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKR----ERKRELEAEFDEARiEEAREDK 655

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024390606 1615 SDEVAARHELEEQIKKLEHDSSSLQSAKARLENECK----------TLQQKVEILGELYQQKE 1667
Cdd:PRK02224   656 ERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEeleelrerreALENRVEALEALYDEAE 718
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1782-1982 3.30e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 3.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1782 PGRPDRQVPPR-RVPLSRDGsfGPSPVSGGNPSPtQMMEVPSRPLSA-----PQREGSRAEFGTVVDG------------ 1843
Cdd:PHA03247  2475 PGAPVYRRPAEaRFPFAAGA--APDPGGGGPPDP-DAPPAPSRLAPAilpdePVGEPVHPRMLTWIRGleelasddagdp 2551

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1844 -PPAPRRPPELPGRMSVPDLGPAvaslissgPRTSSPA-TAKDRAPS-PKEPEAPRVTtdspssiepatvnVGPKGPPsf 1920
Cdd:PHA03247  2552 pPPLPPAAPPAAPDRSVPPPRPA--------PRPSEPAvTSRARRPDaPPQSARPRAP-------------VDDRGDP-- 2608

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024390606 1921 PGTPVMTSPVLGPPPPPPvnygpppaPFPghyGPGPRPLPVPLVCGAPLPPPAARDFLPGPS 1982
Cdd:PHA03247  2609 RGPAPPSPLPPDTHAPDP--------PPP---SPSPAANEPDPHPPPTVPPPERPRDDPAPG 2659
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1349-1713 3.89e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 48.89  E-value: 3.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECD---EKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEE------------TNHQ 1413
Cdd:TIGR00606  747 PELRNKLQKVNRDIQRLKNDIEEQEtllGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQqaaklqgsdldrTVQQ 826

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1414 LDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKK 1493
Cdd:TIGR00606  827 VNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKD 906

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1494 SKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEvltNCIMQLKQLDtDSASEAKDGEGLEWSTKDDLA 1573
Cdd:TIGR00606  907 AKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVK---NIHGYMKDIE-NKIQDGKDDYLKQKETELNTV 982

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1574 NGELPDNEKMKTQIKQMMDASRVKTmlslveeDRNSLQSKLSDEVAARHELEEQIKKLE-----HDSSSLQSAKARLENE 1648
Cdd:TIGR00606  983 NAQLEECEKHQEKINEDMRLMRQDI-------DTQKIQERWLQDNLTLRKRENELKEVEeelkqHLKEMGQMQVLQMKQE 1055

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1649 CKTLQQKVEILGE-----LYQQKEMALQKKLtqeeYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDME 1713
Cdd:TIGR00606 1056 HQKLEENIDLIKRnhvlaLGRQKGYEKEIKH----FKKELREPQFRDAEEKYREMMIVMRTTELVNKDLD 1121
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1360-1549 4.44e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.89  E-value: 4.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1360 QEKTEMLDKFSECDEKIKQAKesmkvAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERKQNAKKQKKL 1439
Cdd:TIGR01612 1521 KDVTELLNKYSALAIKNKFAK-----TKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAA 1595

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1440 SETQKSLEKFEEAFsmhsAELSEVQIALNESKLSEEKVKAELQHVQEEnarlkkSKEQLLKEAEGWSERHTELTEQIKLY 1519
Cdd:TIGR01612 1596 IDIQLSLENFENKF----LKISDIKKKINDCLKETESIEKKISSFSID------SQDTELKENGDNLNSLQEFLESLKDQ 1665

                          170       180       190
                   ....*....|....*....|....*....|
gi 2024390606 1520 RKSQKDIEEALAYKENEIEVLTNCIMQLKQ 1549
Cdd:TIGR01612 1666 KKNIEDKKKELDELDSEIEKIEIDVDQHKK 1695
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1337-1755 4.84e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 48.89  E-value: 4.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1337 LSVKSRMYQVTEKQLAEKIQNLLQEKTEMLDKF----SECDEKIKQAKEsmkvAQEQKSILSDEIAGLKDTVKELEETNH 1412
Cdd:TIGR00606  700 LQSKLRLAPDKLKSTESELKKKEKRRDEMLGLApgrqSIIDLKEKEIPE----LRNKLQKVNRDIQRLKNDIEEQETLLG 775

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1413 QLDDKIKSLRTMLdterkqnaKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKvkaelQHVQEENARLK 1492
Cdd:TIGR00606  776 TIMPEEESAKVCL--------TDVTIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEK-----QEKQHELDTVV 842

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1493 KSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDL 1572
Cdd:TIGR00606  843 SKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQ 922

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1573 ANGELPDNEKMKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSD-EVAARHELEEQIKKLEHDSSSLQSAKARLENECKT 1651
Cdd:TIGR00606  923 QEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDgKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRL 1002

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1652 LQQKVEIlgelYQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYkNQIAAHE 1731
Cdd:TIGR00606 1003 MRQDIDT----QKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQVLQMKQEHQKLEENIDLIKRNH-VLALGRQ 1077

                          410       420
                   ....*....|....*....|....*....
gi 2024390606 1732 KKAHDNWLIA----RSAERALAEEK-REA 1755
Cdd:TIGR00606 1078 KGYEKEIKHFkkelREPQFRDAEEKyREM 1106
PRK11637 PRK11637
AmiB activator; Provisional
 1395-1511 5.52e-05

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 47.77  E-value: 5.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1395 DEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQiaLNESKLSE 1474
Cdd:PRK11637   170 ETIAELKQTREELAAQKAELEEKQSQQKTLLYEQQAQQQKLEQARNERKKTLTGLESSLQKDQQQLSELR--ANESRLRD 247

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2024390606 1475 EKVKAElqhvQEENARlkksKEQLLKEAEGWSERHTE 1511
Cdd:PRK11637   248 SIARAE----REAKAR----AEREAREAARVRDKQKQ 276
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1345-1717 5.91e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 5.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1345 QVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTM 1424
Cdd:COG1196    357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEE 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1425 LDTERKQNAKKQKKLSETQKSLEKFEEAFS--MHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEA 1502
Cdd:COG1196    437 EEEEEEALEEAAEEEAELEEEEEALLELLAelLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1503 EGWSERHTELTEQIKLYRKSQKDIEEALAYKENEI-----EVLTNCIMQLKQ----------LDTDSASEAkDGEGLEWS 1567
Cdd:COG1196    517 AGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIvveddEVAAAAIEYLKAakagratflpLDKIRARAA-LAAALARG 595

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1568 TKDDLANGELPDNEKMKTQIKQMMDASRVKTMLSLVEEDRN-----------------------------SLQSKLSDEV 1618
Cdd:COG1196    596 AIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALrravtlagrlrevtlegeggsaggsltggSRRELLAALL 675

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1619 AARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKLTQ---------------------- 1676
Cdd:COG1196    676 EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEreelleelleeeelleeealee 755

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1677 --EEYERQEKEQKLSAADEK-----AV--LAIEEVKVYKQRIQDMEEELQ 1717
Cdd:COG1196    756 lpEPPDLEELERELERLEREiealgPVnlLAIEEYEELEERYDFLSEQRE 805
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1603-1733 7.31e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 7.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1603 VEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLEN---------ECKTLQQKVEILGELYQQKEmalqKK 1673
Cdd:COG1579     36 LEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgnvrnnkEYEALQKEIESLKRRISDLE----DE 111

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1674 LTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKK 1733
Cdd:COG1579    112 ILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAK 171
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1349-1534 7.80e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 7.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKdtvKELEETNHQLDDKIKSL------- 1421
Cdd:COG3883     26 SELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAE---AEIEERREELGERARALyrsggsv 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1422 ------------------RTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELqh 1483
Cdd:COG3883    103 syldvllgsesfsdfldrLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQ-- 180

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024390606 1484 vQEENARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKE 1534
Cdd:COG3883    181 -EALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAA 230
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1416-1736 8.53e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.79  E-value: 8.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1416 DKIKSLRTMLDTERKQnakKQKKLSETQKSLEKFEEAfsmhsaelsevqiaLNESKLSEEKVKAELQHVQEENARLKKS- 1494
Cdd:pfam05483   88 EKIKKWKVSIEAELKQ---KENKLQENRKIIEAQRKA--------------IQELQFENEKVSLKLEEEIQENKDLIKEn 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1495 ----------KEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEA-LAYKE----------------------------- 1534
Cdd:pfam05483  151 natrhlcnllKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMiLAFEElrvqaenarlemhfklkedhekiqhleee 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1535 --NEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDLANGElpdnEKMKTQIKQMMDASRVKTMLSLVEED-RNSLQ 1611
Cdd:pfam05483  231 ykKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE----EKTKLQDENLKELIEKKDHLTKELEDiKMSLQ 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1612 SKLSDEVAARHELEEQIKKL-----EHDSSSLQSAKAR----------------LENECKTLQQKVEILGELYQQKEMAL 1670
Cdd:pfam05483  307 RSMSTQKALEEDLQIATKTIcqlteEKEAQMEELNKAKaahsfvvtefeattcsLEELLRTEQQRLEKNEDQLKIITMEL 386

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1671 QKKLTQ-EEYERQEKEQKLSAADEKAVLAIEEVKVY-KQRIQDMEEELQKTERSYKNQIAAHEKKAHD 1736
Cdd:pfam05483  387 QKKSSElEEMTKFKNNKEVELEELKKILAEDEKLLDeKKQFEKIAEELKGKEQELIFLLQAREKEIHD 454
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1754-1984 9.79e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.56  E-value: 9.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1754 EAANLRQKLMEVNQKTIMLQRPLIVKPTPGRPDRQVPPRRVPlsrdGSFGPSPVSGGNPSPTQMMEVPSRPLSAPQREGS 1833
Cdd:PRK12323   371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAA----AAAARAVAAAPARRSPAPEALAAARQASARGPGG 446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1834 RAEFGTVVDGPPAPRRPPELPGRMSVPDLGPAVaslissgPRTSSPATAkdRAPSPKEPEAPRVTTDSPSSIEPATVNVG 1913
Cdd:PRK12323   447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAA-------PARAAPAAA--PAPADDDPPPWEELPPEFASPAPAQPDAA 517

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024390606 1914 PKGPPSFPGTPVMTSPVLGPPPPPPVNYGPPPApfpghygPGPRPLPVPLVcgAPLPPPAARDFLPGPSLG 1984
Cdd:PRK12323   518 PAGWVAESIPDPATADPDDAFETLAPAPAAAPA-------PRAAAATEPVV--APRPPRASASGLPDMFDG 579
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1569-1768 1.00e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 47.61  E-value: 1.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1569 KDDLANGELPDNEKMKTQIKQMMDA-SRVKTMLSLVEEDRNSLQSKLSDEVAARHE-----LEEQIKKLEHDSSSLQSAK 1642
Cdd:PRK05771    37 KEELSNERLRKLRSLLTKLSEALDKlRSYLPKLNPLREEKKKVSVKSLEELIKDVEeelekIEKEIKELEEEISELENEI 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1643 ARLENECKTLqqkvEILGELyqqkEMALQKKLTQE-------EYERQEKEQKLSAADEKAVLAIEEVK--------VYKQ 1707
Cdd:PRK05771   117 KELEQEIERL----EPWGNF----DLDLSLLLGFKyvsvfvgTVPEDKLEELKLESDVENVEYISTDKgyvyvvvvVLKE 188

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024390606 1708 RIQDMEEELQKTErsYKNQIAAHEKKAHDnwLIARSAERaLAEEKREAANLRQKLMEVNQK 1768
Cdd:PRK05771   189 LSDEVEEELKKLG--FERLELEEEGTPSE--LIREIKEE-LEEIEKERESLLEELKELAKK 244
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1345-1777 1.17e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 47.35  E-value: 1.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1345 QVTEKQLAEKIQNLLQEKTEMLDKfsECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTM 1424
Cdd:TIGR00606  403 QEDEAKTAAQLCADLQSKERLKQE--QADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQEL 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1425 LDTERKQNAKKQKKLSETQKSLEKFeeafsmhsaeLSEVQIALNESKLSEEKVKAELQHVQEEN------ARLKKSKEQL 1498
Cdd:TIGR00606  481 RKAERELSKAEKNSLTETLKKEVKS----------LQNEKADLDRKLRKLDQEMEQLNHHTTTRtqmemlTKDKMDKDEQ 550

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1499 LKEAEgwSERHTELTEQIKlYRKSQKDIEEALAYKENEIEV-------LTNCIMQLKQLDTDSASEAKDGEGLEWSTKDD 1571
Cdd:TIGR00606  551 IRKIK--SRHSDELTSLLG-YFPNKKQLEDWLHSKSKEINQtrdrlakLNKELASLEQNKNHINNELESKEEQLSSYEDK 627

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1572 L-----ANGELPDNEKMKTQIKQmmdASRVKTMLSLVEEDRNSLQSKLSDEVAA-----------RHELEEQIKKLEHDS 1635
Cdd:TIGR00606  628 LfdvcgSQDEESDLERLKEEIEK---SSKQRAMLAGATAVYSQFITQLTDENQSccpvcqrvfqtEAELQEFISDLQSKL 704

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1636 SSLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKlTQEEYERQEKEQKLSA--ADEKAVLAIEEVKVYKQR----- 1708
Cdd:TIGR00606  705 RLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLK-EKEIPELRNKLQKVNRdiQRLKNDIEEQETLLGTIMpeees 783

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024390606 1709 ----------IQDMEEELQKTERSYKNQIAahEKKAHDNWLIARSAERALAEEKREAANLRQKLmEVNQKTIMLQRPLI 1777
Cdd:TIGR00606  784 akvcltdvtiMERFQMELKDVERKIAQQAA--KLQGSDLDRTVQQVNQEKQEKQHELDTVVSKI-ELNRKLIQDQQEQI 859
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1349-1677 1.19e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.82  E-value: 1.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTE 1428
Cdd:COG4372     41 DKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEEL 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1429 RKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNEskLSEEKVKAELQHVQEENARLKKSKEQLLKEAEGWSER 1508
Cdd:COG4372    121 QKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLES--LQEELAALEQELQALSEAEAEQALDELLKEANRNAEK 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1509 HTELTEQIKLYRKSQKDIEEA---LAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDLANGELPDNEKMKT 1585
Cdd:COG4372    199 EEELAEAEKLIESLPRELAEElleAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEEL 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1586 QIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQ 1665
Cdd:COG4372    279 EIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLEL 358

                          330
                   ....*....|..
gi 2024390606 1666 KEMALQKKLTQE 1677
Cdd:COG4372    359 LSKGAEAGVADG 370
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1346-1673 1.39e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 47.35  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1346 VTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMK-VAQEQKSIlsdEIAGLKdtvkeleeTNHQLDDKIKSLRTM 1424
Cdd:TIGR01612 1412 LDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNEnVLLLFKNI---EMADNK--------SQHILKIKKDNATND 1480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1425 LD---TERKQNAKKQKKLS----ETQKSLEKFEEAFSMHSAELSEVqiaLNesKLSEEKVKAELqhvqeenARLKKSKEQ 1497
Cdd:TIGR01612 1481 HDfniNELKEHIDKSKGCKdeadKNAKAIEKNKELFEQYKKDVTEL---LN--KYSALAIKNKF-------AKTKKDSEI 1548

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1498 LLKEAEGWSERHT---ELTEQ-IKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTdsaseakdgEGLEWSTKDDLA 1573
Cdd:TIGR01612 1549 IIKEIKDAHKKFIleaEKSEQkIKEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFEN---------KFLKISDIKKKI 1619

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1574 NGELPDNEKMKTQIKQMMDASRvKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSakarLENECKTLQ 1653
Cdd:TIGR01612 1620 NDCLKETESIEKKISSFSIDSQ-DTELKENGDNLNSLQEFLESLKDQKKNIEDKKKELDELDSEIEK----IEIDVDQHK 1694

                          330       340
                   ....*....|....*....|
gi 2024390606 1654 QKVEIlGELYQQKEMALQKK 1673
Cdd:TIGR01612 1695 KNYEI-GIIEKIKEIAIANK 1713
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
 523-713 1.67e-04

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 47.01  E-value: 1.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  523 DPDAKEKTNKTEQFEEQLLTDETVLHPEELKSTAvpdppvlhSPGDGLKFKSFVEGKQDALSPPAGDVNQSPEGVLLAET 602
Cdd:NF033875    61 DPQSGSETPKTAVSEEATVQKDTTSQPTKVEEVA--------SEKNGAEQSSATPNDTTNAQQPTVGAEKSAQEQPVVSP 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  603 EKEEEKFGGDTLKESSENNFKHRKLWEKM-------KEKGKAKYEPSGDVLAKPVEDVQNTSQSDTGDTDLLKDKLEQEM 675
Cdd:NF033875   133 ETTNEPLGQPTEVAPAENEANKSTSIPKEfetpdvdKAVDEAKKDPNITVVEKPAEDLGNVSSKDLAAKEKEVDQLQKEQ 212

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2024390606  676 PvveKEILRQEEDLKQTREADHENQRPISVKKEPEIER 713
Cdd:NF033875   213 A---KKIAQQAAELKAKNEKIAKENAEIAAKNKAEKER 247
PHA03378 PHA03378
EBNA-3B; Provisional
 1778-1971 1.71e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.98  E-value: 1.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1778 VKPTPGRPdrqvpPRRVPLSRDGSFGPSPVSGGNPSPTQmmEVPSRPLS-APQREGSRAEfgtvvdgPPAPRRPPEL-PG 1855
Cdd:PHA03378   647 VFPTPHQP-----PQVEITPYKPTWTQIGHIPYQPSPTG--ANTMLPIQwAPGTMQPPPR-------APTPMRPPAApPG 712

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1856 RMSVPDLGPAVASLISSGP-RTSSPATAKDRAPSPK-EPEAPRVTTDSPSSIEPATVNVG---PKGPPSFPGTPvmtspv 1930
Cdd:PHA03378   713 RAQRPAAATGRARPPAAAPgRARPPAAAPGRARPPAaAPGRARPPAAAPGRARPPAAAPGaptPQPPPQAPPAP------ 786

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2024390606 1931 lgppppppvNYGPPPAPFPghyGPGPRPLPVPLVCGAPLPP 1971
Cdd:PHA03378   787 ---------QQRPRGAPTP---QPPPQAGPTSMQLMPRAAP 815
PHA03378 PHA03378
EBNA-3B; Provisional
 1780-2046 1.73e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.98  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1780 PTPGRPDRQVPPRRVPLSRDGSFGPSP-------VSGGNPSPTQMMEVPSRPLSApqregsraefgtvvdGPPAPRRPPE 1852
Cdd:PHA03378   625 PMPLRPIPMRPLRMQPITFNVLVFPTPhqppqveITPYKPTWTQIGHIPYQPSPT---------------GANTMLPIQW 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1853 LPGRMSVPDLGPAVASLISSGP-RTSSPATAKDRAPSPKEpeaprvttdSPSSIEPATVNVGPKGPPSFPGTPVMTSPVL 1931
Cdd:PHA03378   690 APGTMQPPPRAPTPMRPPAAPPgRAQRPAAATGRARPPAA---------APGRARPPAAAPGRARPPAAAPGRARPPAAA 760

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1932 GPPPPPPVNYGPPPAPFPGHYGPgPRPLPVPLVCGAPLPPP----AARDFLPgPSLGIRDLPPGPLPPLPDPRSYRRGHP 2007
Cdd:PHA03378   761 PGRARPPAAAPGAPTPQPPPQAP-PAPQQRPRGAPTPQPPPqagpTSMQLMP-RAAPGQQGPTKQILRQLLTGGVKRGRP 838

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 2024390606 2008 HFRPpgppgprdyppgpplpppasrdyaPSRSRDLPPAG 2046
Cdd:PHA03378   839 SLKK------------------------PAALERQAAAG 853
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1607-1768 1.80e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.55  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1607 RNSLQSKLSDEVAARHELEEQIKKLEHDsssLQSAKARLENecktLQQKVEIL-----GELYQQKEMALQKKLTQEEYER 1681
Cdd:COG3206    163 EQNLELRREEARKALEFLEEQLPELRKE---LEEAEAALEE----FRQKNGLVdlseeAKLLLQQLSELESQLAEARAEL 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1682 QEKEQKLSAADEK---------AVLAIEEVKVYKQRIQDMEEELQKTERSYKNQ----IAAHEKKAHDNWLIARSAERAL 1748
Cdd:COG3206    236 AEAEARLAALRAQlgsgpdalpELLQSPVIQQLRAQLAELEAELAELSARYTPNhpdvIALRAQIAALRAQLQQEAQRIL 315

                          170       180
                   ....*....|....*....|
gi 2024390606 1749 AEEKREAANLRQKLMEVNQK 1768
Cdd:COG3206    316 ASLEAELEALQAREASLQAQ 335
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1349-1678 2.43e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.10  E-value: 2.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDkfsecdEKIKQAKESMKVAQEQKSILsdeiaglkdtVKELEETNHQLDDKIKSLRTMLDTE 1428
Cdd:COG5185    249 AQTSDKLEKLVEQNTDLRL------EKLGENAESSKRLNENANNL----------IKQFENTKEKIAEYTKSIDIKKATE 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1429 RKQNakkQKKLSETQKSLE-KFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENaRLKKSKEQLLKEAEGWSE 1507
Cdd:COG5185    313 SLEE---QLAAAEAEQELEeSKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEV-ELSKSSEELDSFKDTIES 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1508 RHTELTEQIKLYRKSQKDIEEALA--YKENEIEvLTNCIMQLKQLDTDSASEAKDGEGLEWSTkdDLANGELPDNEKMKT 1585
Cdd:COG5185    389 TKESLDEIPQNQRGYAQEILATLEdtLKAADRQ-IEELQRQIEQATSSNEEVSKLLNELISEL--NKVMREADEESQSRL 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1586 QIKQMMDASRVKTMLSLVEEDRNSLQSKLSdevAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEIlgELYQQ 1665
Cdd:COG5185    466 EEAYDEINRSVRSKKEDLNEELTQIESRVS---TLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGY--AHILA 540

                          330
                   ....*....|...
gi 2024390606 1666 KEMALQKKLTQEE 1678
Cdd:COG5185    541 LENLIPASELIQA 553
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1354-1530 2.78e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 2.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1354 KIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSlrtmlDTERKQNA 1433
Cdd:COG1579     11 DLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK-----YEEQLGNV 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1434 KKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEgwsERHTELT 1513
Cdd:COG1579     86 RNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELE---AELEELE 162

                          170
                   ....*....|....*..
gi 2024390606 1514 EQIKLYRKSqkdIEEAL 1530
Cdd:COG1579    163 AEREELAAK---IPPEL 176
PRK11281 PRK11281
mechanosensitive channel MscK;
1380-1729 3.40e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 46.06  E-value: 3.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1380 KESMKVAQEQKSILSDEiaglKDTVKELEETNHQLDdKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAE 1459
Cdd:PRK11281    42 QAQLDALNKQKLLEAED----KLVQQDLEQTLALLD-KIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1460 -LSEVQIALNESKLSEekVKAELQHVQEE----NARLKKSKEQllkeaegwSERhtelteqiklyrkSQKDIEEALAyke 1534
Cdd:PRK11281   117 tLSTLSLRQLESRLAQ--TLDQLQNAQNDlaeyNSQLVSLQTQ--------PER-------------AQAALYANSQ--- 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1535 neievltncimQLKQLDTDSASEAKDGEGLEWSTKDDLaNGELpdnekmktqikQMMDASrvktmlslVEEDRNSLQ--S 1612
Cdd:PRK11281   171 -----------RLQQIRNLLKGGKVGGKALRPSQRVLL-QAEQ-----------ALLNAQ--------NDLQRKSLEgnT 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1613 KLSDEVAARHEL-EEQIKKLEHDSSSLQSA--KARLENECKTLQQ------KVEILGELYQQKEMALQKKLTQEeyerqe 1683
Cdd:PRK11281   220 QLQDLLQKQRDYlTARIQRLEHQLQLLQEAinSKRLTLSEKTVQEaqsqdeAARIQANPLVAQELEINLQLSQR------ 293

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2024390606 1684 keqKLSAADEKAVLAIEEVKVyKQRIqdmeEELQKTERSYKNQIAA 1729
Cdd:PRK11281   294 ---LLKATEKLNTLTQQNLRV-KNWL----DRLTQSERNIKEQISV 331
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 1639-1727 3.49e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 43.29  E-value: 3.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1639 QSAKARLENECKTLQQKVEILGELYQQKEMALQKK---LTQEeyERQEKEQKLSAADEKavlaieevkvYKQRIQDMEEE 1715
Cdd:COG2825     42 KAAQKKLEKEFKKRQAELQKLEKELQALQEKLQKEaatLSEE--ERQKKERELQKKQQE----------LQRKQQEAQQD 109

                           90
                   ....*....|..
gi 2024390606 1716 LQKTERSYKNQI 1727
Cdd:COG2825    110 LQKRQQELLQPI 121
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1400-1732 3.75e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 45.66  E-value: 3.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1400 LKDTVKELEETNHQLD---DKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNE-SKLSEE 1475
Cdd:PRK01156   171 LKDVIDMLRAEISNIDyleEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNElSSLEDM 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1476 KVKAE---------LQHVQEENARLKKSKEQLLK---------------------EAEGWSERHTELTEQIKLYRKSQKD 1525
Cdd:PRK01156   251 KNRYEseiktaesdLSMELEKNNYYKELEERHMKiindpvyknrnyindyfkyknDIENKKQILSNIDAEINKYHAIIKK 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1526 IEEALAY------KENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKDDLANGELPDNEKMKTQIKQMMDASRVKTM 1599
Cdd:PRK01156   331 LSVLQKDyndyikKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKE 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1600 LSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSakarlENECKTL-----QQKVEILGELYQQKEMALQKKL 1674
Cdd:PRK01156   411 LNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNG-----QSVCPVCgttlgEEKSNHIINHYNEKKSRLEEKI 485

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024390606 1675 TQEEYE----RQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEK 1732
Cdd:PRK01156   486 REIEIEvkdiDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDK 547
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1583-1760 3.86e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.15  E-value: 3.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1583 MKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSdevaarhELEEQIKKLEHD-------SSSLQSAKARLENECKTLQQK 1655
Cdd:COG1579      2 MPEDLRALLDLQELDSELDRLEHRLKELPAELA-------ELEDELAALEARleaakteLEDLEKEIKRLELEIEEVEAR 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1656 VEI----LGELYQQKEM-ALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAH 1730
Cdd:COG1579     75 IKKyeeqLGNVRNNKEYeALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAEL 154

                          170       180       190
                   ....*....|....*....|....*....|
gi 2024390606 1731 EKKahdnwLIARSAERALAEEKREAANLRQ 1760
Cdd:COG1579    155 EAE-----LEELEAEREELAAKIPPELLAL 179
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1772-2036 4.56e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 4.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1772 LQRPLIVKPTPG-RPDRQVPPRRVPLSRDGSFGPSPVSGGNPSPTQMMEVPSRPlSAPQREGSRAefgtVVDGPPA---P 1847
Cdd:PHA03247  2698 LADPPPPPPTPEpAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP-GGPARPARPP----TTAGPPApapP 2772

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1848 RRPPELPGRMSVPdlgPAVASLISSGPRTSSPATAKDRAPSPKEPEAPRVTTDSPSSIEPATVNVGPKGPPSFPGtPVMT 1927
Cdd:PHA03247  2773 AAPAAGPPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG-PPPP 2848

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1928 SPvlgppppppvnygpppaPFPGHYGPG------PRPLPVPLVCGAPLPPPAARDFLPGPS-----LGIRDLPPGPLPPL 1996
Cdd:PHA03247  2849 SL-----------------PLGGSVAPGgdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSrstesFALPPDQPERPPQP 2911

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2024390606 1997 PDPRSYRRGHPHFRPPGPPGPRDYPPGPPLPPPASRDYAP 2036
Cdd:PHA03247  2912 QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1780-2048 5.21e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 5.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1780 PTPGrPDRQVPPRRVPLSRDGSFGPSPVSGGNPSPTQMMEVPSRPLSAPQREGSRAEFGTVVDGPPAPRRPPELPGrmsv 1859
Cdd:PHA03307   128 PSPA-PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAA---- 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1860 PDLGPAVASLISSGPRTSSPATAKDRApSPKEPEAPRVTTDSPSSIEPATVNVGPKGPPSFPGTPvmTSPVLGPPPPPPV 1939
Cdd:PHA03307   203 SPRPPRRSSPISASASSPAPAPGRSAA-DDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLP--TRIWEASGWNGPS 279

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1940 NYGPPPAPFPGHYGPGPRPLP-VPLVCGAPLPPPAARDFLPGPSLGIrdLPPGPLPPLPDPRSYRRGHPHFRPPGPPgpr 2018
Cdd:PHA03307   280 SRPGPASSSSSPRERSPSPSPsSPGSGPAPSSPRASSSSSSSRESSS--SSTSSSSESSRGAAVSPGPSPSRSPSPS--- 354

                          250       260       270
                   ....*....|....*....|....*....|
gi 2024390606 2019 dyppgpplPPPASRDYAPSRSRDLPPAGPR 2048
Cdd:PHA03307   355 --------RPPPPADPSSPRKRPRPSRAPS 376
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1474-1768 5.30e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 5.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1474 EEKVKAELQHVQEEnarlKKSKEQLLKEAEGWS----ERHTELTEQIKLYRKSQKDIEEALAYKENeievltncimQLKQ 1549
Cdd:TIGR04523   35 EKQLEKKLKTIKNE----LKNKEKELKNLDKNLnkdeEKINNSNNKIKILEQQIKDLNDKLKKNKD----------KINK 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1550 LDTDS---ASEAKDGEGLEWSTKDDLANGELPDNEKMKTQIKqmmdasrVKTMLSLVEEDRNSLQSKLSDEVAARHELEE 1626
Cdd:TIGR04523  101 LNSDLskiNSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDK-------FLTEIKKKEKELEKLNNKYNDLKKQKEELEN 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1627 QIKKLEHDSSSLQSAKARLENECKTLQQKVEILgELYQQKEMALQKKLT--------------QEEYERQEKEQKLSAAD 1692
Cdd:TIGR04523  174 ELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNL-KKKIQKNKSLESQISelkkqnnqlkdnieKKQQEINEKTTEISNTQ 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1693 EKAVLAIEEVKVYKQRIQDMEEELQKTER----------SYKNQIAAHEKKAHDNWLIARSAEraLAEEKREAANLRQKL 1762
Cdd:TIGR04523  253 TQLNQLKDEQNKIKKQLSEKQKELEQNNKkikelekqlnQLKSEISDLNNQKEQDWNKELKSE--LKNQEKKLEEIQNQI 330


                   ....*.
gi 2024390606 1763 MEVNQK 1768
Cdd:TIGR04523  331 SQNNKI 336
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1801-1974 5.67e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 5.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1801 SFGPSPVSGGNPSPT-------QMMEVPSRPLSAPQREGSRAEFGTVVDGPPAPRRPP-ELPGRMSVP--DLGPAVASLI 1870
Cdd:PRK12323   362 AFRPGQSGGGAGPATaaaapvaQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVaAAPARRSPApeALAAARQASA 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1871 SSGPRTSSPATAKDRAPSPKEPEA-------PRVTTDSPSSIEPATVNV-GPKGPPSFPGTPV-MTSPVLGPPPPPPVNY 1941
Cdd:PRK12323   442 RGPGGAPAPAPAPAAAPAAAARPAaagprpvAAAAAAAPARAAPAAAPApADDDPPPWEELPPeFASPAPAQPDAAPAGW 521

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2024390606 1942 GPPPAPFPGHYGP-GPRPLPVPLVCGAPLPPPAA 1974
Cdd:PRK12323   522 VAESIPDPATADPdDAFETLAPAPAAAPAPRAAA 555
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1638-1761 5.91e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 44.11  E-value: 5.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1638 LQSAKARLENECKTLQQKVEILGELYQQKEmALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQ 1717
Cdd:cd16269    151 REKLVEKYRQVPRKGVKAEEVLQEFLQSKE-AEAEAILQADQALTEKEKEIEAERAKAEAAEQERKLLEEQQRELEQKLE 229

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2024390606 1718 KTERSYKNQIAAHEKK-AHDNWLIARSAERALAEEKREAANLRQK 1761
Cdd:cd16269    230 DQERSYEEHLRQLKEKmEEERENLLKEQERALESKLKEQEALLEE 274
DUF4200 pfam13863
Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil ...
 1337-1423 6.42e-04

Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.


Pssm-ID: 464003 [Multi-domain]  Cd Length: 119  Bit Score: 41.40  E-value: 6.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1337 LSVKSRMYQVTEKQLAEKIQNL------LQEKTEMLDKFS-ECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEE 1409
Cdd:pfam13863   15 LDAKREEIERLEELLKQREEELekkeqeLKEDLIKFDKFLkENDAKRRRALKKAEEETKLKKEKEKEIKKLTAQIEELKS 94

                           90
                   ....*....|....
gi 2024390606 1410 TNHQLDDKIKSLRT 1423
Cdd:pfam13863   95 EISKLEEKLEEYKP 108
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1785-2005 6.76e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 6.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1785 PDRQVPPRRVPLSRDGSFGPSPVSGGNPSPTqmmEVPSRPLSAPQREGSRAEFGTVVDGPPAPRrPPELPGRMSVPDLGP 1864
Cdd:PHA03307    61 ACDRFEPPTGPPPGPGTEAPANESRSTPTWS---LSTLAPASPAREGSPTPPGPSSPDPPPPTP-PPASPPPSPAPDLSE 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1865 AVASLISSGPR--TSSPATAKDRAPSPKEPEAPRVTTDsPSSIEPATVNVGPKGPPSFPGT--PVMTSPVLGPPPPPPVN 1940
Cdd:PHA03307   137 MLRPVGSPGPPpaASPPAAGASPAAVASDAASSRQAAL-PLSSPEETARAPSSPPAEPPPStpPAAASPRPPRRSSPISA 215

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1941 YGPPPAPFPGHYGPGPRP-------LPVPLVCG------APLPPPAARDFLPGPSLGIRDLPPGPLPPLPDPRSYRRG 2005
Cdd:PHA03307   216 SASSPAPAPGRSAADDAGasssdssSSESSGCGwgpeneCPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRE 293
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1359-1694 7.74e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 7.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1359 LQEKTEMLDKfsecdeKIKQAKEsmkvAQEQKSILSDEIAGLKDTV-----------KELEETNHQLDDK---------- 1417
Cdd:pfam10174  354 LEEKESFLNK------KTKQLQD----LTEEKSTLAGEIRDLKDMLdvkerkinvlqKKIENLQEQLRDKdkqlaglker 423

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1418 IKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAE-LSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKE 1496
Cdd:pfam10174  424 VKSLQTDSSNTDTALTTLEEALSEKERIIERLKEQREREDRErLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKE 503

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1497 Q-------------LLKEAEGWSERHTEltEQIKLYRKSQKDIEEALAYKENE-----IEVLTNCIMQLKQLDTDSASEA 1558
Cdd:pfam10174  504 HasslassglkkdsKLKSLEIAVEQKKE--ECSKLENQLKKAHNAEEAVRTNPeindrIRLLEQEVARYKEESGKAQAEV 581

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1559 -------KDGEGLEWSTKDDLANGELPDNEKMKTQIK-----QMMDASRVKTMLSLVEEDRNSLQSKLSDevAARHELEE 1626
Cdd:pfam10174  582 erllgilREVENEKNDKDKKIAELESLTLRQMKEQNKkvaniKHGQQEMKKKGAQLLEEARRREDNLADN--SQQLQLEE 659

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1627 QIKKLEHDSSSLQSAKARLENECKTLQQKVEILGELYQQKEMALqkkltqEEYERQEKEQKLSAADEK 1694
Cdd:pfam10174  660 LMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNLRAERRKQL------EEILEMKQEALLAAISEK 721
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 1780-1981 7.86e-04

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 43.44  E-value: 7.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1780 PTPGRPDRQVP----------PRRVPLSRDGSFGPSPVSGGnPSPTQMMevPSRPLSAPQregsraefgtvvDGPPAPRR 1849
Cdd:pfam15822   21 PKPGQPPQGWPgsnpwnnpsaPPAVPSGLPPSTAPSTVPFG-PAPTGMY--PSIPLTGPS------------PGPPAPFP 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1850 PPELpgrmSVPDLGPAVASLISSGPRTSSPATAkdraPSPKEPEAPRVTTDSPSSIEPATVnvGPKGP-PSFPGTPVMTS 1928
Cdd:pfam15822   86 PSGP----SCPPPGGPYPAPTVPGPGPIGPYPT----PNMPFPELPRPYGAPTDPAAAAPS--GPWGSmSSGPWAPGMGG 155

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1929 PVLGPPPPPPVN---YGPPPAPFPGHYGPGPRPLPVPLVCG--APLPPPAARDFLPGP 1981
Cdd:pfam15822  156 QYPAPNMPYPSPgpyPAVPPPQSPGAAPPVPWGTVPPGPWGppAPYPDPTGSYPMPGL 213
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1348-1506 8.67e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.85  E-value: 8.67e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  1348 EKQLAEKIQNLLQEKTEmLDKFSEcdeKIKQAKESMkvaQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSlrtMLDT 1427
Cdd:smart00787  146 KEGLDENLEGLKEDYKL-LMKELE---LLNSIKPKL---RDRKDALEEELRQLKQLEDELEDCDPTELDRAKE---KLKK 215

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024390606  1428 ERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNEsklsEEKVKAELQHVQEENARLKKSKEQLLKEAEGWS 1506
Cdd:smart00787  216 LLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAE----AEKKLEQCRGFTFKEIEKLKEQLKLLQSLTGWK 290
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1469-1774 9.47e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 44.58  E-value: 9.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1469 ESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQkdiEEALAYKENEIEVLTNCIMQLK 1548
Cdd:pfam02463  633 ELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAES---ELAKEEILRRQLEIKKKEQREK 709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1549 QLDTDSASEAKDGEGLEWSTKDDLANGELPDNEKMKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQI 1628
Cdd:pfam02463  710 EELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVE 789

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1629 KKLEHDssslqsaKARLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQR 1708
Cdd:pfam02463  790 EEKEEK-------LKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEE 862

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024390606 1709 IQDMEEELQKTERSYKNQIAAHEKKAHdnwliarsaeraLAEEKreaanlrqklmEVNQKTIMLQR 1774
Cdd:pfam02463  863 ITKEELLQELLLKEEELEEQKLKDELE------------SKEEK-----------EKEEKKELEEE 905
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1639-1727 1.02e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 41.41  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1639 QSAKARLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYERQEKEQKLSAADEKavlaieevkvYKQRIQDMEEELQK 1718
Cdd:pfam03938   18 KAAQAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQE----------LQQLQQKAQQELQK 87


                   ....*....
gi 2024390606 1719 TERSYKNQI 1727
Cdd:pfam03938   88 KQQELLQPI 96
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1377-1768 1.16e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.99  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1377 KQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTmLDTERKQNAKKQKKLSETQKSLEKFEEAFSMH 1456
Cdd:COG4717     53 KEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEE-LEEELEELEAELEELREELEKLEKLLQLLPLY 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1457 SAElsevqialnesklseEKVKAELQHVQEenaRLkkskEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENE 1536
Cdd:COG4717    132 QEL---------------EALEAELAELPE---RL----EELEERLEELRELEEELEELEAELAELQEELEELLEQLSLA 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1537 --------IEVLTNCIMQLKQLDTDSASEAKDGEGLEwSTKDDLANGELPDNEKMKTQIKQMM----------------- 1591
Cdd:COG4717    190 teeelqdlAEELEELQQRLAELEEELEEAQEELEELE-EELEQLENELEAAALEERLKEARLLlliaaallallglggsl 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1592 --DASRVKTMLSLV------------------EEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSslqSAKARLENECKT 1651
Cdd:COG4717    269 lsLILTIAGVLFLVlgllallflllarekaslGKEAEELQALPALEELEEEELEELLAALGLPPD---LSPEELLELLDR 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1652 LQQKVEILGELyqqkeMALQKKLTQEEYErQEKEQKLSAAD-------EKAVLAIEEVKVYKQRIQDMEEELQKTERSYK 1724
Cdd:COG4717    346 IEELQELLREA-----EELEEELQLEELE-QEIAALLAEAGvedeeelRAALEQAEEYQELKEELEELEEQLEELLGELE 419

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2024390606 1725 NQIAAHEKKAHDNWLiaRSAERALAEEKREAANLRQKLMEVNQK 1768
Cdd:COG4717    420 ELLEALDEEELEEEL--EELEEELEELEEELEELREELAELEAE 461
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1774-1976 1.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1774 RPLIVKPTPGRPDRQVPPRRVPlsrDGSFGPSpVSGGNPS-PTQMMEVPSRPLSAPQREGSRAEFGTVVDGPPAPRR--P 1850
Cdd:PHA03247   273 RGATGPPPPPEAAAPNGAAAPP---DGVWGAA-LAGAPLAlPAPPDPPPPAPAGDAEEEDDEDGAMEVVSPLPRPRQhyP 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1851 PELPGRMSVPDLGPAVASLISSG---PRTSSPATAKDR-APSPKEP--------EAPRVTTDSPSSIEPATVNVGPKGPP 1918
Cdd:PHA03247   349 LGFPKRRRPTWTPPSSLEDLSAGrhhPKRASLPTRKRRsARHAATPfargpggdDQTRPAAPVPASVPTPAPTPVPASAP 428

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1919 SFPGTPVMTSPVlgppppppvnygpppapfPGHYGPGPRPLPVPLVCGAPLPPPAARD 1976
Cdd:PHA03247   429 PPPATPLPSAEP------------------GSDDGPAPPPERQPPAPATEPAPDDPDD 468
46 PHA02562
endonuclease subunit; Provisional
 1391-1648 1.22e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.85  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1391 SILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLDTERK----QNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIA 1466
Cdd:PHA02562   163 SVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQIKTYNKnieeQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDE 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1467 LNESKLSEEKVKAELQHVQEENARLKKSKEQLLKEAEGWSERHT--ELTEQIklyrKSQKDIEEALAYKeneievLTNCI 1544
Cdd:PHA02562   243 LLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKMYEKGGVcpTCTQQI----SEGPDRITKIKDK------LKELQ 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1545 MQLKQLDT--DSASEAKDgeglewstkddlangELPDNEKMKTQIKQmmDASRVKTMLSLVEEDRNSLQSKLSDEVAARH 1622
Cdd:PHA02562   313 HSLEKLDTaiDELEEIMD---------------EFNEQSKKLLELKN--KISTNKQSLITLVDKAKKVKAAIEELQAEFV 375

                          250       260
                   ....*....|....*....|....*.
gi 2024390606 1623 ELEEQIKKLEHDSSSLQSAKARLENE 1648
Cdd:PHA02562   376 DNAEELAKLQDELDKIVKTKSELVKE 401
Rab5-bind pfam09311
Rabaptin-like protein; Members of this family are predominantly found in Rabaptin and allow ...
 1398-1658 1.29e-03

Rabaptin-like protein; Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes.


Pssm-ID: 462752 [Multi-domain]  Cd Length: 307  Bit Score: 43.03  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1398 AGLKDTVKELEETNHQLDDKIKslRTMldTERKQNAKKQKKLS-ETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEK 1476
Cdd:pfam09311   19 AETRDQVKKLQEMLRQANDQLE--KTM--KDKKELEDKMNQLSeETSNQVSTLAKRNQKSETLLDELQQAFSQAKRNFQD 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1477 ----VKAELQHVQEENARLKKSKEQLLkeaeGWSERHTEL--TEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQL 1550
Cdd:pfam09311   95 qlavLMDSREQVSDELVRLQKDNESLQ----GKHSLHVSLqqAEKFDMPDTVQELQELVLKYREELIEVRTAADHMEEKL 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1551 DtDSASEAKDGEGLEWSTKDDLANGELPDNEKMKTQIKQMmdaSRVKTMLSLVEEDRNSLQSKLSDEVAA-------RHE 1623
Cdd:pfam09311  171 K-AEILFLKEQIQAEQCLKENLEETLQAEIENCKEEIASI---SSLKVELERIKAEKEQLENGLTEKIRQledlqttKGS 246

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2024390606 1624 LEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEI 1658
Cdd:pfam09311  247 LETQLKKETNEKAAVEQLVFEEKNKAQRLQTELDV 281
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1381-1778 1.33e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.17  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1381 ESMKVAQEQKsilsDEIAGL---------KDTVKELEETNHQLDDKIkSLRTMLDTERKQNAKKQKKLSETQKSLEKFEE 1451
Cdd:COG3096    246 EAIRVTQSDR----DLFKHLiteatnyvaADYMRHANERRELSERAL-ELRRELFGARRQLAEEQYRLVEMARELEELSA 320

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1452 AFSMHSAE-------LSEVQIALNEsklsEEKVKAELQHVQEENARLKKSKEQlLKEAEgwsERHTELTEQIKLYRKSQK 1524
Cdd:COG3096    321 RESDLEQDyqaasdhLNLVQTALRQ----QEKIERYQEDLEELTERLEEQEEV-VEEAA---EQLAEAEARLEAAEEEVD 392

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1525 DIEEALAYKENEIEVLTNCIMQLKQldtdsASEAKdGEGLEWSTKDDLAngelPDNekmktqIKQMMDASRVKtmLSLVE 1604
Cdd:COG3096    393 SLKSQLADYQQALDVQQTRAIQYQQ-----AVQAL-EKARALCGLPDLT----PEN------AEDYLAAFRAK--EQQAT 454

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1605 EDRNSLQSKLSDEVAARHELEEQIKKLE------HDSSSLQSAKARLEN--ECKTLQQKVEILGELYQQKEMALQKkltQ 1676
Cdd:COG3096    455 EEVLELEQKLSVADAARRQFEKAYELVCkiagevERSQAWQTARELLRRyrSQQALAQRLQQLRAQLAELEQRLRQ---Q 531

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1677 EEYERQEKE------QKLSAADEKAVLA------IEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKKAhDNWLIARSA 1744
Cdd:COG3096    532 QNAERLLEEfcqrigQQLDAAEELEELLaeleaqLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARA-PAWLAAQDA 610

                          410       420       430
                   ....*....|....*....|....*....|....
gi 2024390606 1745 ERALAEEKREAANLRQKLMEVNQKTIMLQRPLIV 1778
Cdd:COG3096    611 LERLREQSGEALADSQEVTAAMQQLLEREREATV 644
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1347-1672 1.42e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.60  E-value: 1.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1347 TEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKEsmkvAQEQKSILSDEIAGLKDTVKELEETNHQLD---DKIKSLRT 1423
Cdd:COG4717    102 EELEELEAELEELREELEKLEKLLQLLPLYQELEA----LEAELAELPERLEELEERLEELRELEEELEeleAELAELQE 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1424 MLDTERKQ-NAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEEN-------------- 1488
Cdd:COG4717    178 ELEELLEQlSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEErlkearlllliaaa 257

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1489 ---------------------------------ARLKKSKEQLLKEAEgwseRHTELTEQIKLYRKSQKDIEEALAYKEN 1535
Cdd:COG4717    258 llallglggsllsliltiagvlflvlgllallfLLLAREKASLGKEAE----ELQALPALEELEEEELEELLAALGLPPD 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1536 -EIEVLTNCIMQLKQLDTDSASEAKDGEGLEW----------------STKDDLANG-----ELPDNEKMKTQIKQMMDA 1593
Cdd:COG4717    334 lSPEELLELLDRIEELQELLREAEELEEELQLeeleqeiaallaeagvEDEEELRAAleqaeEYQELKEELEELEEQLEE 413

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024390606 1594 SRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENEcktlqqkvEILGELYQQKEMALQK 1672
Cdd:COG4717    414 LLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEED--------GELAELLQELEELKAE 484
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1412-1538 1.50e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.22  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1412 HQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKA---------ELQ 1482
Cdd:COG1579     13 QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgnvrnnkEYE 92

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024390606 1483 HVQEENARLKKSKEQLLKEAEGWSERHTELTEQIKLYRKSQKDIEEALAYKENEIE 1538
Cdd:COG1579     93 ALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELD 148
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1349-1508 1.70e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.35  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLD-- 1426
Cdd:pfam07888   76 RELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELErm 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1427 TERKQNAKKQKKLSETQKS-----LEKFEEAFSMHSAELSEVQIALNESKLSEEKVK---AELQHVQEENARLKKSKEQL 1498
Cdd:pfam07888  156 KERAKKAGAQRKEEEAERKqlqakLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQdtiTTLTQKLTTAHRKEAENEAL 235

                          170
                   ....*....|
gi 2024390606 1499 LKEAEGWSER 1508
Cdd:pfam07888  236 LEELRSLQER 245
PRK11281 PRK11281
mechanosensitive channel MscK;
1338-1776 2.03e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 43.36  E-value: 2.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1338 SVKSRMYQVTEKQLAEKIQNLLQ---EKT-EMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDT-VKELEETNH 1412
Cdd:PRK11281    40 DVQAQLDALNKQKLLEAEDKLVQqdlEQTlALLDKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDnDEETRETLS 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1413 QLDdkIKSLRTMLDTERKQNAKKQKKLSET-------QKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQH-V 1484
Cdd:PRK11281   120 TLS--LRQLESRLAQTLDQLQNAQNDLAEYnsqlvslQTQPERAQAALYANSQRLQQIRNLLKGGKVGGKALRPSQRVlL 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1485 QEENARLKKSKEQLLKEAEG-------WSERHTELTEQIKLYRKSQKDIEEALAYKeneievltncimQLKQLDtDSASE 1557
Cdd:PRK11281   198 QAEQALLNAQNDLQRKSLEGntqlqdlLQKQRDYLTARIQRLEHQLQLLQEAINSK------------RLTLSE-KTVQE 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1558 AKDGEGLEWSTKDDLANGELPDNEKM-KTQIKQ-------MMDASRVKTML-SLVEEDRNslqsklsdevaarheLEEQI 1628
Cdd:PRK11281   265 AQSQDEAARIQANPLVAQELEINLQLsQRLLKAteklntlTQQNLRVKNWLdRLTQSERN---------------IKEQI 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1629 KKLEhdsSSLqsakarlenecktLQQKVeilgeLYQQKEMALQKKLTQEeyerqekeqklsAADEKAVLAIEEVKVYKQR 1708
Cdd:PRK11281   330 SVLK---GSL-------------LLSRI-----LYQQQQALPSADLIEG------------LADRIADLRLEQFEINQQR 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1709 --IQDMEEELQKTERSYKNQIAAHEKKAHDNWLIARSA-----ERALAEEKREAANLrqklmEVNQKTIM-----LQRPL 1776
Cdd:PRK11281   377 daLFQPDAYIDKLEAGHKSEVTDEVRDALLQLLDERRElldqlNKQLNNQLNLAINL-----QLNQQQLLsvsdsLQSTL 451
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1774-1938 2.31e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 2.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1774 RPLIVKPTPGRPDRQVPPRRVPLSRDGSFGPSPvSGGNPSPtqmmEVPSRPLSAPQREGSRAEFGTVVDGPPAPRRPPEL 1853
Cdd:PHA03307   261 APITLPTRIWEASGWNGPSSRPGPASSSSSPRE-RSPSPSP----SSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSES 335

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1854 PGRMSVPdLGPAVASLISSGpRTSSPATAKDRAPSPKEPEAPRVTTDSPSSIEPATV-------NVGPKGPPSFPGT--- 1923
Cdd:PHA03307   336 SRGAAVS-PGPSPSRSPSPS-RPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRAraavagrARRRDATGRFPAGrpr 413

                          170
                   ....*....|....*
gi 2024390606 1924 PVMTSPVLGPPPPPP 1938
Cdd:PHA03307   414 PSPLDAGAASGAFYA 428
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 1780-1921 2.33e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 42.45  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1780 PTPGRPDRQVP--PRRVPLSRD-GSFGPSPVSGGNPSPTQMMEVPSRPLSA--PQREGSRAEFGTVVDGPPAPRRPPELP 1854
Cdd:NF040712   190 PDFGRPLRPLAtvPRLAREPADaRPEEVEPAPAAEGAPATDSDPAEAGTPDdlASARRRRAGVEQPEDEPVGPGAAPAAE 269

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024390606 1855 GRMSVPDLGPAVASLISSGPrtSSPATAKDRAPSPKEPEAPRVTTDSPSSIEPATVNVGPKGPPSFP 1921
Cdd:NF040712   270 PDEATRDAGEPPAPGAAETP--EAAEPPAPAPAAPAAPAAPEAEEPARPEPPPAPKPKRRRRRASVP 334
Tektin pfam03148
Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular ...
 1403-1725 2.57e-03

Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilization of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.


Pssm-ID: 460827 [Multi-domain]  Cd Length: 383  Bit Score: 42.54  E-value: 2.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1403 TVKELEETNHQLDDKIKSL---RTMLDTERKQNAKKQKKLSETQKSLEKFEEAFsmhsaelsEVQIALNESKLS--EEKV 1477
Cdd:pfam03148   37 TKWDQYDSNRRLGERIQDItfwKSELEKELEELDEEIELLLEEKRRLEKALEAL--------EEPLHIAQECLTlrEKRQ 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1478 KAELQH--VQEEnarLKKSKEqLLKEAEGWSERHTE-LTEQIKLYRKSQKDIEEALAYKENEIEVLTNCImqlkQLDTDS 1554
Cdd:pfam03148  109 GIDLVHdeVEKE---LLKEVE-LIEGIQELLQRTLEqAWEQLRLLRAARHKLEKDLSDKKEALEIDEKCL----SLNNTS 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1555 AS----------EAKDGEGLEWS--TKDDLANGElpdNEKMKT-QIKQMMDASRVKT------MLSLVEEdrnSLQSKLS 1615
Cdd:pfam03148  181 PNisykpgptriPPNSSTPEEWEkfTQDNIERAE---KERAASaQLRELIDSILEQTandlraQADAVNF---ALRKRIE 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1616 DEVAARHELEEQIKKLEHDssslqsaKARLENECKTLQQKVeilgelyQQKEMALqkKLTQEEYE-----------RQEK 1684
Cdd:pfam03148  255 ETEDAKNKLEWQLKKTLQE-------IAELEKNIEALEKAI-------RDKEAPL--KLAQTRLEnrtyrpnvelcRDEA 318

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2024390606 1685 EQKLsaadekavlaIEEVKVYKQRIQDMEEELQKTERSYKN 1725
Cdd:pfam03148  319 QYGL----------VDEVKELEETIEALKQKLAEAEASLQA 349
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1348-1722 2.74e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 43.04  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1348 EKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDE------IAGLKDTVKELEETNHQLDDKIKSL 1421
Cdd:pfam02463  249 EQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEElksellKLERRKVDDEEKLKESEKEKKKAEK 328

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1422 RTMLDTERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENARLKKSKEQLLKE 1501
Cdd:pfam02463  329 ELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQ 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1502 AEgwsERHTELTEQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEwsTKDDLANGELPDNE 1581
Cdd:pfam02463  409 LL---LELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKK--SEDLLKETQLVKLQ 483

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1582 KMKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEILGE 1661
Cdd:pfam02463  484 EQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEER 563

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024390606 1662 LYQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEELQKTERS 1722
Cdd:pfam02463  564 QKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKV 624
PHA03379 PHA03379
EBNA-3A; Provisional
 1785-1984 2.96e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 42.74  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1785 PDRQVPPRRVPLSRDGSFGPSPVSGGNPSPTqmmEVPS------RPLSAPQREGSRAEFGTVVDgPPAPRRPPELPGRMS 1858
Cdd:PHA03379   466 PVAQLPPGPLQDLEPGDQLPGVVQDGRPACA---PVPApagpivRPWEASLSQVPGVAFAPVMP-QPMPVEPVPVPTVAL 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1859 VPDLGPAVASLISSGP-RTSSPATAKDR------APSPKEPEAPRVTTDSPSSIEP------ATVNVGP----KGPPSFP 1921
Cdd:PHA03379   542 ERPVCPAPPLIAMQGPgETSGIVRVRERwrpapwTPNPPRSPSQMSVRDRLARLRAeaqpyqASVEVQPpqltQVSPQQP 621

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024390606 1922 -GTPVMTSPVLGPPPPPPVNYGPPPAPFPGHYGPGPRPLPV--PLVCGAPLPPPAArDFLPGPSLG 1984
Cdd:PHA03379   622 mEYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQPQYFDLPLqqPISQGAPLAPLRA-SMGPVPPVP 686
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1407-1718 3.03e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 42.80  E-value: 3.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1407 LEETNHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKfeeafsMHSAELSEVQIALNESKlSEEKVKAELQHVQE 1486
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQE------MQMERDAMADIRRRESQ-SQEDLRNQLQNTVH 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1487 ENARLKKSKEQLLKEAEGWSE--RHTELTEQIKLY--RKSQKDIEEALAYKENEIEVLTNCIMQ---------LKQLDTd 1553
Cdd:pfam15921  153 ELEAAKCLKEDMLEDSNTQIEqlRKMMLSHEGVLQeiRSILVDFEEASGKKIYEHDSMSTMHFRslgsaiskiLRELDT- 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1554 sasEAKDGEGLEWSTKDDLANGELPDNEKMKTQIKQMMDasRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEH 1633
Cdd:pfam15921  232 ---EISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQD--RIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQE 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1634 DSSSLQSAKARlenECKTLQQKVEILgelyqQKEMALQKKLTQEEYErqEKEQKLSAADEKAVLAIEEVKVYKQRIQDME 1713
Cdd:pfam15921  307 QARNQNSMYMR---QLSDLESTVSQL-----RSELREAKRMYEDKIE--ELEKQLVLANSELTEARTERDQFSQESGNLD 376


                   ....*
gi 2024390606 1714 EELQK 1718
Cdd:pfam15921  377 DQLQK 381
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 600-843 3.08e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 42.68  E-value: 3.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  600 AETEKEEEKFGGDTLKESSENNFKHRKLWEkMKEKGKAKYEPSGDVLAKPVE---DVQNTSQSDTGDTDLLKDKLEQEMP 676
Cdd:TIGR00927  655 AEGENGEESGGEAEQEGETETKGENESEGE-IPAERKGEQEGEGEIEAKEADhkgETEAEEVEHEGETEAEGTEDEGEIE 733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  677 VVEKEILRQEEDLKQTrEADHENQRPiSVKKEPEIERGSMKETSADErDPSRRGAAEQPRPWENETEYSEADVKEELSRN 756
Cdd:TIGR00927  734 TGEEGEEVEDEGEGEA-EGKHEVETE-GDRKETEHEGETEAEGKEDE-DEGEIQAGEDGEMKGDEGAEGKVEHEGETEAG 810

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  757 LGKMTIFEERIEKSSPEEKSKSAAQNTNAENstqQGTAHTDNEDSDRNLGTSSARETtlrlELQSEEPDAEEDPDLKQEE 836
Cdd:TIGR00927  811 EKDEHEGQSETQADDTEVKDETGEQELNAEN---QGEAKQDEKGVDGGGGSDGGDSE----EEEEEEEEEEEEEEEEEEE 883


                   ....*..
gi 2024390606  837 ELLEDEN 843
Cdd:TIGR00927  884 EEEEEEN 890
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1350-1688 3.51e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.63  E-value: 3.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1350 QLAEKIQNLLQEktemldkFSECDEKIKQAKESMKVAQEQKSilsdeiaglkdtvkELEETNHQLDDKIKSLRTML---- 1425
Cdd:COG3096    344 RQQEKIERYQED-------LEELTERLEEQEEVVEEAAEQLA--------------EAEARLEAAEEEVDSLKSQLadyq 402

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1426 ---DT------------ERKQNAKKQKKLSE-TQKSLEKFEEAFSMHSAELSEVQIALnESKLSEekvkAELQHVQEENA 1489
Cdd:COG3096    403 qalDVqqtraiqyqqavQALEKARALCGLPDlTPENAEDYLAAFRAKEQQATEEVLEL-EQKLSV----ADAARRQFEKA 477

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1490 RlkkskeQLLKEAEGWSER---HTELTEQIKLYRkSQKdieeALAYKENEIEvltnciMQLKQLDTDSASEAKDGEGLEw 1566
Cdd:COG3096    478 Y------ELVCKIAGEVERsqaWQTARELLRRYR-SQQ----ALAQRLQQLR------AQLAELEQRLRQQQNAERLLE- 539

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1567 stkddlangelpdnEKMKTQIKQMMDASRVKTMLSLVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQS------ 1640
Cdd:COG3096    540 --------------EFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAArapawl 605

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024390606 1641 -AKARLENECKTLQQKVEILGELYQQKEMALQK--KLTQEEYERQEKEQKL 1688
Cdd:COG3096    606 aAQDALERLREQSGEALADSQEVTAAMQQLLERerEATVERDELAARKQAL 656
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
1623-1765 3.53e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 41.96  E-value: 3.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1623 ELEEQIKKLEhdsSSLQSAKARLENECKTLQQKVEILGELYQQKEMALQKKLTQEEYERQEKEQKLSAADEKAVLAIE-E 1701
Cdd:COG1566     80 DLQAALAQAE---AQLAAAEAQLARLEAELGAEAEIAAAEAQLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARaA 156

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024390606 1702 VKVYKQRIQDMEEELQKTersyKNQIAAHEKKAhdnwliARSAERALAEEKREAANLRQKLMEV 1765
Cdd:COG1566    157 LDAAQAQLEAAQAQLAQA----QAGLREEEELA------AAQAQVAQAEAALAQAELNLARTTI 210
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1468-1730 3.62e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 3.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1468 NESKLseEKVKAELQHVQEENARLKKSKEQLLKEAEGWSERHTELtEQIKLYRKSQKDIEEAlaykENEIEVLTNcimQL 1547
Cdd:COG4913    608 NRAKL--AALEAELAELEEELAEAEERLEALEAELDALQERREAL-QRLAEYSWDEIDVASA----EREIAELEA---EL 677

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1548 KQLDTDSaseakdgeglewstkDDLAngelpdnekmktqikqmmdasrvktmlslveedrnSLQSKLSDEVAARHELEEQ 1627
Cdd:COG4913    678 ERLDASS---------------DDLA-----------------------------------ALEEQLEELEAELEELEEE 707

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1628 IKKLEHDSSSLQSAKARLENECKTLQQKVEILGELyqqkemalqkkltQEEYERQEKEQKLSAADEKAVLAiEEVKVYKQ 1707
Cdd:COG4913    708 LDELKGEIGRLEKELEQAEEELDELQDRLEAAEDL-------------ARLELRALLEERFAAALGDAVER-ELRENLEE 773

                          250       260
                   ....*....|....*....|...
gi 2024390606 1708 RIQDMEEELQKTERSYKNQIAAH 1730
Cdd:COG4913    774 RIDALRARLNRAEEELERAMRAF 796
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1342-1677 3.71e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 42.73  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1342 RMYQVTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSL 1421
Cdd:TIGR00606  294 KVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSL 373

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1422 RTMLDT---ERKQNAKKQKKLSETQKsLEKFEEAFSMHSAELSEVQ--IALNESKLSE--EKVKAELQHVQEENARLKKS 1494
Cdd:TIGR00606  374 ATRLELdgfERGPFSERQIKNFHTLV-IERQEDEAKTAAQLCADLQskERLKQEQADEirDEKKGLGRTIELKKEILEKK 452

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1495 KEQL------LKEAEGWSERHTELTEQIklyRKSQKDIeeALAYKENEIEVLTNCIMQLK--QLDTDSASEAKDGEglew 1566
Cdd:TIGR00606  453 QEELkfvikeLQQLEGSSDRILELDQEL---RKAEREL--SKAEKNSLTETLKKEVKSLQneKADLDRKLRKLDQE---- 523

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1567 stkddlaNGELpdnEKMKTQIKQMMDASRVKTMlslVEEDRNSLQSKLSDEVAARHELEEQIKKLEHDSSSLQSAKARLE 1646
Cdd:TIGR00606  524 -------MEQL---NHHTTTRTQMEMLTKDKMD---KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTR 590

                          330       340       350
                   ....*....|....*....|....*....|.
gi 2024390606 1647 NECKTLQQKVEILGELYQQKEMALQKKLTQE 1677
Cdd:TIGR00606  591 DRLAKLNKELASLEQNKNHINNELESKEEQL 621
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1347-1758 3.71e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 42.73  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1347 TEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTvKELEETNHQLDDKIKSLRTMLD 1426
Cdd:TIGR00606  516 KLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNK-KQLEDWLHSKSKEINQTRDRLA 594

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1427 TERKQNAKKQKKLSETQKSLEKFEEAFSMHSAELSEVqialneskLSEEKVKAELQHVQEENARLKKSKEQLLKEAEGWS 1506
Cdd:TIGR00606  595 KLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDV--------CGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYS 666

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1507 ERHTELTEQ-------IKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSASEAKDGEGLEWSTKD--DLANGEL 1577
Cdd:TIGR00606  667 QFITQLTDEnqsccpvCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSiiDLKEKEI 746

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1578 PD----NEKMKTQIKQMM-DASRVKTMLSLVEEDRNSLQSKLSDEVAARH---ELEEQIKKLEHDSSSLQSAKARL---- 1645
Cdd:TIGR00606  747 PElrnkLQKVNRDIQRLKnDIEEQETLLGTIMPEEESAKVCLTDVTIMERfqmELKDVERKIAQQAAKLQGSDLDRtvqq 826

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1646 --------ENECKTLQQKVEILGELYQQKE---MALQKKLTQEEYER---QEKEQKLSAADEKAVLAIEEVKVYKQRIQD 1711
Cdd:TIGR00606  827 vnqekqekQHELDTVVSKIELNRKLIQDQQeqiQHLKSKTNELKSEKlqiGTNLQRRQQFEEQLVELSTEVQSLIREIKD 906

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 2024390606 1712 MEEELQKTERSYKNQIAAHEKKAHDNWLIARSAERALAEEKREAANL 1758
Cdd:TIGR00606  907 AKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNI 953
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1620-1773 4.21e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 4.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1620 ARHELEEQIKKLEhdsssLQSAKA----RLENECKTLQqkVEILGELYQQKE---MALQKKLTQEEYERQEKEQKLSAAD 1692
Cdd:TIGR02168  194 ILNELERQLKSLE-----RQAEKAerykELKAELRELE--LALLVLRLEELReelEELQEELKEAEEELEELTAELQELE 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1693 EKavlaIEEVKVYKQRIQDMEEELQKTERSYKNQIAA--HEKKAHDNWLiaRSAERALAEEKREAANLRQKLMEVNQKTI 1770
Cdd:TIGR02168  267 EK----LEELRLEVSELEEEIEELQKELYALANEISRleQQKQILRERL--ANLERQLEELEAQLEELESKLDELAEELA 340


                   ...
gi 2024390606 1771 MLQ 1773
Cdd:TIGR02168  341 ELE 343
PTZ00121 PTZ00121
MAEBL; Provisional
 670-1189 4.47e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 4.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  670 KLEQEMPVVEKEILRQEEDLKQTREADHENQRPISVKKEPEIERGSMKETSADERDPSRRGAAEQPRPWENETEYSEADV 749
Cdd:PTZ00121  1237 KDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKK 1316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  750 KEELSRNLGKMTIFEERIEKSSPEEKSKSAAQNTNAENSTQQGTAHTDNEDSDRnLGTSSARETTLRLELQSEEPDAEED 829
Cdd:PTZ00121  1317 ADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAE-KKKEEAKKKADAAKKKAEEKKKADE 1395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  830 PDLKQEEELLEDENAASAKLLQARLANIQGNAQTTRSTNPDLGVLSEAvsgtvnptyETGEKTNSFSEDTKEISRVQDAH 909
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEA---------KKADEAKKKAEEAKKAEEAKKKA 1466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  910 EVGNK--EVDKPVSEDTKLDEIEHVMEDNKESSE-----AEEPSAVEEydFKSPDREDSNDFNQRKGHLPEGLLLGDSEE 982
Cdd:PTZ00121  1467 EEAKKadEAKKKAEEAKKADEAKKKAEEAKKKADeakkaAEAKKKADE--AKKAEEAKKADEAKKAEEAKKADEAKKAEE 1544

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606  983 IQNSEDTRNAHQ-HSAHFPSPADMSAATNDtvtDYSESVKRLTITRDfLDEKRVIRLQKYLGLQNVIRIEAM--FQDMKI 1059
Cdd:PTZ00121  1545 KKKADELKKAEElKKAEEKKKAEEAKKAEE---DKNMALRKAEEAKK-AEEARIEEVMKLYEEEKKMKAEEAkkAEEAKI 1620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1060 EMELARKAsqnnEEIEKALDQILKSSDSSI-----------MDVVGKVLDSRVAENQEEVVKEMDLYDEE-----SALMD 1123
Cdd:PTZ00121  1621 KAEELKKA----EEEKKKVEQLKKKEAEEKkkaeelkkaeeENKIKAAEEAKKAEEDKKKAEEAKKAEEDekkaaEALKK 1696

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024390606 1124 DIQELIYSLRSKYSSASESVPLGSFL-EQEEDQLHVQGAAKEAENDAAPGRNLHGTDESSQKFQQLE 1189
Cdd:PTZ00121  1697 EAEEAKKAEELKKKEAEEKKKAEELKkAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLK 1763
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1447-1763 5.52e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 42.03  E-value: 5.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1447 EKFEEAFSMHSAELSEVQIALNESKLSEEKVKAelqHVQEENARLKKSKEQLLKEAEGWSE-RHTELTEQIKLYRKSQKD 1525
Cdd:pfam15921   74 EHIERVLEEYSHQVKDLQRRLNESNELHEKQKF---YLRQSVIDLQTKLQEMQMERDAMADiRRRESQSQEDLRNQLQNT 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1526 IEEALAYKENEIEVLTNCIMQLKQLDTDSASEakdgEGLEWSTKDDLANGELPDNEKMKTQikQMMDASRVKTMLSLVEE 1605
Cdd:pfam15921  151 VHELEAAKCLKEDMLEDSNTQIEQLRKMMLSH----EGVLQEIRSILVDFEEASGKKIYEH--DSMSTMHFRSLGSAISK 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1606 DRNSLQSKLSDEVAARHELEEQIKKLEHDSSS-----LQSAKARLENECKtlQQKVEILGELYQQKEMALQKKLTQEEYE 1680
Cdd:pfam15921  225 ILRELDTEISYLKGRIFPVEDQLEALKSESQNkiellLQQHQDRIEQLIS--EHEVEITGLTEKASSARSQANSIQSQLE 302

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1681 RQEKEqklsaADEKAVLAIEEVKVYKQRIQDMEEELQKTERSYKNQIAAHEKK---AHDNWLIARSAERALAEEKREAAN 1757
Cdd:pfam15921  303 IIQEQ-----ARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQlvlANSELTEARTERDQFSQESGNLDD 377


                   ....*.
gi 2024390606 1758 LRQKLM 1763
Cdd:pfam15921  378 QLQKLL 383
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1349-1448 5.55e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 5.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1349 KQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQK--SILSDEIAGLKDTVKELEETNHQLDDKIKSLRTMLD 1426
Cdd:COG1579     48 EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKeyEALQKEIESLKRRISDLEDEILELMERIEELEEELA 127

                           90       100
                   ....*....|....*....|..
gi 2024390606 1427 TERKQNAKKQKKLSETQKSLEK 1448
Cdd:COG1579    128 ELEAELAELEAELEEKKAELDE 149
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 1331-1768 5.63e-03

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 41.59  E-value: 5.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1331 IFWRTCLSVKSRMYQVTEKqlaekIQNLLqektEMLDKFSECDEKIKQAKESMKVAQEQKSI--LSDEIAGLKDTVKE-- 1406
Cdd:COG5244     62 IFIRPDDDSLLNGNAAYEK-----IKGGL----VCESKGMDKDGEIKQENHEDRIHFEESKIrrLEETIEALKSTEKEei 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1407 --LEETNHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQ-KSLEKFEEAFSMHSAEL-SEVQIALN------ESKLSEEK 1476
Cdd:COG5244    133 veLRRENEELDKINLSLRERISSEEPELNKDGSKLSYDElKEFVEESRVQVYDMVELvSDISETLNrngsiqRSSVRECE 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1477 VKAELQHVQEENARLKKSKEQLLKEAEGWSERHTEL--TEQIKLYRKS--QKDIEEALAYkENEIEVLTNCIMQLKQLDT 1552
Cdd:COG5244    213 RSNIHDVLFLVNGILDGVIDELNGELERLRRQLVSLmsSHGIEVEENSrlKATLEKFQSL-ELKVNTLQEELYQNKLLKK 291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1553 -----DSASEAKDGEGLEWSTK-------DDLANGELPDNEKMKTQIKQMMDASRVKTMLSLVEEDRNS----------L 1610
Cdd:COG5244    292 fyqiyEPFAQAALSSQLQYLAEviesenfGKLENIEIHIILKVLSSISYALHIYTIKNTPDHLETTLQCfvniapismwL 371

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1611 QSKLSDEVAARHELEEQI-KKLEHDSSSLQSAKARL----ENECKTLQ--------QKVEILGELYQQKEMALQKKLTqe 1677
Cdd:COG5244    372 SEFLQRKFSSKQETAFSIcQFLEDNKDVTLILKILHpileTTVPKLLAflrtnsnfNDNDTLCLIGSLYEIARIDKLI-- 449

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1678 eyERQEKEQKLSAADEKAVLAIEEVKVYKQRIQDMEEE-LQKTERSYKNQIAAHEKKahdnwliarSAERALAEEKREAA 1756
Cdd:COG5244    450 --GKEEISKQDNRLFLYPSCDITLSSILTILFSDKLEVfFQGIESLLENITIFPEQP---------SQQTSDSENIKENS 518

                          490
                   ....*....|..
gi 2024390606 1757 NLRQKLMEVNQK 1768
Cdd:COG5244    519 LLSDRLNEENIR 530
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1408-1718 6.03e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.70  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1408 EETNHQLDDKIKSLRTMLDTERKQNAK---KQKKLS------------------ETQKSLEKFEEAFSMHSAELSEVQIA 1466
Cdd:pfam01576  741 EEKRRQLVKQVRELEAELEDERKQRAQavaAKKKLEldlkeleaqidaankgreEAVKQLKKLQAQMKDLQRELEEARAS 820

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1467 ----LNESKLSEEKVK---AELQHVQEENA---RLKKSKEQLLKE-----AEGWSERHTELTEQIKLYRKSQkDIEEALA 1531
Cdd:pfam01576  821 rdeiLAQSKESEKKLKnleAELLQLQEDLAaseRARRQAQQERDEladeiASGASGKSALQDEKRRLEARIA-QLEEELE 899

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1532 YKENEIEVLTN----CIMQLKQLDTDSASEAKDGEGLEWStkddlangelpdNEKMKTQIKQMmdasrvKTMLSlveEDR 1607
Cdd:pfam01576  900 EEQSNTELLNDrlrkSTLQVEQLTTELAAERSTSQKSESA------------RQQLERQNKEL------KAKLQ---EME 958

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1608 NSLQSKLSDEVAArheLEEQIKKLEHdssslqsakaRLENECKTLQQKveilGELYQQKEMALQKKLTQEEYERQEKEQK 1687
Cdd:pfam01576  959 GTVKSKFKSSIAA---LEAKIAQLEE----------QLEQESRERQAA----NKLVRRTEKKLKEVLLQVEDERRHADQY 1021

                          330       340       350
                   ....*....|....*....|....*....|.
gi 2024390606 1688 LSAADEkavlAIEEVKVYKQRIQDMEEELQK 1718
Cdd:pfam01576 1022 KDQAEK----GNSRMKQLKRQLEEAEEEASR 1048
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1345-1503 6.24e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 6.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1345 QVTEKQLAEKIQNLLQE-KTEMLDKFSEC---DEKIKQAKESMKVAQEQ-KSILSDEIAGLKDTVKE-LEETNHQLDDKI 1418
Cdd:COG4717    362 ELQLEELEQEIAALLAEaGVEDEEELRAAleqAEEYQELKEELEELEEQlEELLGELEELLEALDEEeLEEELEELEEEL 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1419 KSLRTMLDTERKQNAKKQKKLS--ETQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEKVKAELQHVQEENArlkkskE 1496
Cdd:COG4717    442 EELEEELEELREELAELEAELEqlEEDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERL------P 515


                   ....*..
gi 2024390606 1497 QLLKEAE 1503
Cdd:COG4717    516 PVLERAS 522
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1351-1559 6.25e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 41.99  E-value: 6.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1351 LAEKIQNLLQEKTEMLDKFSECDEK------IKQAKESMKVAQEQKSILSDEIAGLKDTVKELEETNHQLDDKIKSLRTM 1424
Cdd:COG5022    911 LKKSLSSDLIENLEFKTELIARLKKllnnidLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDLLKKSTILVREGNKA 990

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1425 LDterkQNAKKQKKLSETQKSLEKFEEafsmHSAELSEVQIALNESKLSEEKVKAELQHVQEENaRLKKSKEQLLKEAeg 1504
Cdd:COG5022    991 NS----ELKNFKKELAELSKQYGALQE----STKQLKELPVEVAELQSASKIISSESTELSILK-PLQKLKGLLLLEN-- 1059

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024390606 1505 wsERHTELTEQIKLYRKSQKDIE------EALAYKENEIEVLtncimQLKQLDTDSASEAK 1559
Cdd:COG5022   1060 --NQLQARYKALKLRRENSLLDDkqlyqlESTENLLKTINVK-----DLEVTNRNLVKPAN 1113
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1346-1508 6.99e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.38  E-value: 6.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1346 VTEKQLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSILSDEIAGLKDTVKELEE----------TNHQLD 1415
Cdd:COG2433    385 LIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERelsearseerREIRKD 464

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1416 DKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEafsMHSAELSEVQIALNE-SKLSEEKVKAelqhvQEENARLKKS 1494
Cdd:COG2433    465 REISRLDREIERLERELEEERERIEELKRKLERLKE---LWKLEHSGELVPVKVvEKFTKEAIRR-----LEEEYGLKEG 536

                          170
                   ....*....|....
gi 2024390606 1495 KEQLLKEAEGWSER 1508
Cdd:COG2433    537 DVVYLRDASGAGRS 550
PRK12704 PRK12704
phosphodiesterase; Provisional
 1352-1496 6.99e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 6.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1352 AEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKvAQEQKsiLSDEIAGLKDTVKELEETNHQLDDKIKSlrtmLDTERKQ 1431
Cdd:PRK12704    53 AIKKEALLEAKEEIHKLRNEFEKELRERRNELQ-KLEKR--LLQKEENLDRKLELLEKREEELEKKEKE----LEQKQQE 125

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024390606 1432 NAKKQKKLSE-TQKSLEKFEEAFSMHSAELSEVQIALNESKLSEEkvKAELQHVQEENARL---KKSKE 1496
Cdd:PRK12704   126 LEKKEEELEElIEEQLQELERISGLTAEEAKEILLEKVEEEARHE--AAVLIKEIEEEAKEeadKKAKE 192
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1339-1676 7.10e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.54  E-value: 7.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1339 VKSRMyqvtekqLAEKIQNLLQEKTEMLDKFSECDEKIKQAKESMKVAQEQKSIL-----SDEIAGL-KDTVKELEET-- 1410
Cdd:COG3206     90 LKSRP-------VLERVVDKLNLDEDPLGEEASREAAIERLRKNLTVEPVKGSNVieisyTSPDPELaAAVANALAEAyl 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1411 NHQLDDKIKSLRTMLDTERKQNAKKQKKLSETQKSLEKFEEAfsmHSAELSEVQIALNESKLSEekVKAELQHVQEENAR 1490
Cdd:COG3206    163 EQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQK---NGLVDLSEEAKLLLQQLSE--LESQLAEARAELAE 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1491 LKKSKEQLLKEAEGWSERHTELTE--QIKLYRKSQKDIEEALAykeneievltncimQLKQLDTDSASEAKDgeglewst 1568
Cdd:COG3206    238 AEARLAALRAQLGSGPDALPELLQspVIQQLRAQLAELEAELA--------------ELSARYTPNHPDVIA-------- 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1569 kddlANGELpdnEKMKTQIKQmmdasRVKTMLSLVEEDRNSLQSKLSdevaarhELEEQIKKLEHDSSSLQSAKARLENe 1648
Cdd:COG3206    296 ----LRAQI---AALRAQLQQ-----EAQRILASLEAELEALQAREA-------SLQAQLAQLEARLAELPELEAELRR- 355

                          330       340       350
                   ....*....|....*....|....*....|...
gi 2024390606 1649 cktLQQKVEILGELYQQ-----KEMALQKKLTQ 1676
Cdd:COG3206    356 ---LEREVEVARELYESllqrlEEARLAEALTV 385
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1373-1768 8.24e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.31  E-value: 8.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1373 DEKIKQAKESMKVAQEQKSILSDEiaglkdtVKELEETNHQLDDKIKSLRTMLDTER-----------KQNAKKQKK--- 1438
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESE-------LKELEKKHQQLCEEKNALQEQLQAETelcaeaeemraRLAARKQELeei 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1439 LSETQKSLEKFEEAFSMHSAELSEVQ--IALNESKLSEE---KVKAELQHVQEEnARLKKSKEQLLKEAegwsERHTELT 1513
Cdd:pfam01576   77 LHELESRLEEEEERSQQLQNEKKKMQqhIQDLEEQLDEEeaaRQKLQLEKVTTE-AKIKKLEEDILLLE----DQNSKLS 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1514 EQIKLYRKSQKDIEEALAYKENEIEVLTNCIMQLKQLDTDSA----SEAKDGEGLE-WSTKDDLANGELPDN-EKMKTQI 1587
Cdd:pfam01576  152 KERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEerlkKEEKGRQELEkAKRKLEGESTDLQEQiAELQAQI 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1588 KQMmdasrvKTMLSLVEEDRNSLQSKLSDEVAAR-------HELEEQIKKLEHDSSSLQSAKARLENECKTLQQKVEIL- 1659
Cdd:pfam01576  232 AEL------RAQLAKKEEELQAALARLEEETAQKnnalkkiRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALk 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1660 GELyqqkEMALQKKLTQEEYeRQEKEQKLsaADEKAVLAiEEVKVYKQRIQDME-------EELQKTERSYKNQIAAHEK 1732
Cdd:pfam01576  306 TEL----EDTLDTTAAQQEL-RSKREQEV--TELKKALE-EETRSHEAQLQEMRqkhtqalEELTEQLEQAKRNKANLEK 377

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 2024390606 1733 KAHdnwliarSAERALAEEKREAANLRQKLMEVNQK 1768
Cdd:pfam01576  378 AKQ-------ALESENAELQAELRTLQQAKQDSEHK 406
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 1820-1975 8.75e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 39.29  E-value: 8.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024390606 1820 VPSRPLSAPQREGSRAEFGTVVDGPPAPRRPPELPGRMSVPDLGPAVASLISSGPRTSSPATA--KDRAPSPKEPEAPRV 1897
Cdd:cd21975     21 VRPDPEGAGLAAGLDVRATREVAKGPGPPGPAWKPDGADSPGLVTAAPHLLAANVLAPLRGPSveGSSLESGDADMGSDS 100

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024390606 1898 TTDSPSSIEPATVNVGPKGPPSFPGTPvmtspvlgppppppvnyGPPPAPFPGHYGPGPRPLPVPLVCGAPLPPPAAR 1975
Cdd:cd21975    101 DVAPASGAAASTSPESSSDAASSPSPL-----------------SLLHPGEAGLEPERPRPRVRRGVRRRGVTPAAKR 161
DUF6730 pfam20503
Family of unknown function (DUF6730); This family of proteins is functionally uncharacterized. ...
 1393-1448 9.10e-03

Family of unknown function (DUF6730); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 105 and 155 amino acids in length.


Pssm-ID: 466652  Cd Length: 82  Bit Score: 37.11  E-value: 9.10e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024390606 1393 LSDEIAGLKDTVKELEETNHQLDD-KIK--------SLRTMLDTERKQNAKKQKKLSETQKSLEK 1448
Cdd:pfam20503   11 LTEEIEGFNKSVERLEKLSQQLKDtKIKidtseiekLLEEHLKQQKKKLEEQEEFLREIEKKLKK 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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