|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
664-965 |
4.71e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 136.31 E-value: 4.71e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 664 GHDDDILSLSIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLASVGLDdnHAIVFWDWK 743
Cdd:cd00200 7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSD--KTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 744 KGEKLATTRGHKDKIFVVKCNPHHvdKLVTVGMKH--IKFWQQTGGGFTSrrgTFgsSGKLETMMSVSYGRIEDLVFSGA 821
Cdd:cd00200 82 TGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVETGKCLT---TL--RGHTDWVNSVAFSPDGTFVASSS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 822 ATGDIFIW--KDTLLLKTVKAHDGPVFAMHALDKG--FVTGGKDGIVALWDDMFERCLKTYAIKRAAlsssskgllledn 897
Cdd:cd00200 155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------- 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024393284 898 psIRAIS-LGHGHILV-GTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPVCATVSDDKTLRIWE 965
Cdd:cd00200 222 --VNSVAfSPDGYLLAsGSEDGTIRVWDlRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
647-1079 |
1.32e-34 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 138.51 E-value: 1.32e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 647 AVAVVYNRQQHSQRLYLGHDDDILSLSIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCL 726
Cdd:COG2319 59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 727 ASVGLDdnHAIVFWDWKKGEKLATTRGHKDKIFVVkcnphhvdklvtvgmkhikfwqqtgggftsrrgTFGSSGKLetmm 806
Cdd:COG2319 136 ASGSAD--GTVRLWDLATGKLLRTLTGHSGAVTSV---------------------------------AFSPDGKL---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 807 svsygriedlVFSGAATGDIFIW--KDTLLLKTVKAHDGPVFAMHALDKG--FVTGGKDGIVALWDdmferclktyaikr 882
Cdd:COG2319 177 ----------LASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGklLASGSADGTVRLWD-------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 883 aalsssskglllednpsiraislghghilvgTKNGEILeidksgpmtLLVQGHmEGEVWGLAAHP---LLpvcATVSDDK 959
Cdd:COG2319 233 -------------------------------LATGKLL---------RTLTGH-SGSVRSVAFSPdgrLL---ASGSADG 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 960 TLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSReTGKYLAV 1039
Cdd:COG2319 269 TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLAS 347
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 2024393284 1040 ASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 1079
Cdd:COG2319 348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
190-531 |
5.11e-31 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 127.72 E-value: 5.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 190 ATGGRDGCIRLWDTDfkpiTKIDLReTEQGYKGlSIRSVCWKAD--RLLAGTQDSEIfEVLVRERDKPMLIMQGHcEGEL 267
Cdd:COG2319 94 ASASADGTVRLWDLA----TGLLLR-TLTGHTG-AVRSVAFSPDgkTLASGSADGTV-RLWDLATGKLLRTLTGH-SGAV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 268 WALAVHPKKPLAVTGSDDRSVRLWSLADHALIARCN-MEEAVRSVSFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDR 346
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 347 KEVIHEMKFSPDGSYLAVGSNDGPVDIYAVAQRyKKIGECNKSSSFITHIDWSVDSKFLQTNDGAGERLFYKMPSGKHLT 426
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 427 nkdEIKGIHWASWTCVIgsevngiwpkytnvtdvnSVDGNYnssvLVTGDDFGLVKLFRfpcLRKGAKFRKYVGHSAHVT 506
Cdd:COG2319 325 ---TLTGHTGAVRSVAF------------------SPDGKT----LASGSDDGTVRLWD---LATGELLRTLTGHTGAVT 376
|
330 340
....*....|....*....|....*
gi 2024393284 507 NVRWSHDFQWVLStGGADHSVFQWQ 531
Cdd:COG2319 377 SVAFSPDGRTLAS-GSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1410-1895 |
4.33e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 125.02 E-value: 4.33e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1410 SATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLCKKGVIGSm 1489
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1490 edakmqTMLSVAFGANNLTF-TGAINGDVYVWK-DHFLVRLVAKAHTGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKL 1566
Cdd:COG2319 80 ------AVLSVAFSPDGRLLaSASADGTVRLWDlATGLLLRTLTGHTGAVRSV-AFSPDGkTLASGS------ADGTVRL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1567 WDqemkrcrafqLETGQLIecvrsvcrgkgKILVGtkdgeilevgeknaasnllidcHmEGEIWGLATHPSKDLFISASN 1646
Cdd:COG2319 147 WD----------LATGKLL-----------RTLTG----------------------H-SGAVTSVAFSPDGKLLASGSD 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1647 DGTARIWDLCDKKLLNKVNlGHPA--RCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFL 1724
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLT-GHTGavRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1725 AVGSQEHTVDFYDLTQGTTLNRIGyckDIASFVIQMDFSADSRYIqVSTGAYKRqVHevplgkqITDTATIEKITWATwt 1804
Cdd:COG2319 262 ASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLL-ASGSDDGT-VR-------LWDLATGKLLRTLT-- 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1805 silgdevigiwprnADKADVNCACVTHAGLNIVTGDDFGLVKLFDfpcTEKFAKHKRYFGHSAHVTNIRFSHDDNYVISt 1884
Cdd:COG2319 328 --------------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS- 389
|
490
....*....|.
gi 2024393284 1885 GGDDCSVFVWR 1895
Cdd:COG2319 390 GSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
718-1205 |
7.29e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 118.48 E-value: 7.29e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 718 DFSADGKCLASVGLDDNHAIvfWDWKKGEKLATTRGHKDKIFVVKCNPHHVDKLVTVGMKHIKFWQQTGGGFTSRRgtfg 797
Cdd:COG2319 1 ALSADGAALAAASADLALAL--LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL---- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 798 sSGKLETMMSVSYGRIEDLVFSGAATGDIFIW--KDTLLLKTVKAHDGPVFAM--HALDKGFVTGGKDGIVALWDdmfer 873
Cdd:COG2319 75 -LGHTAAVLSVAFSPDGRLLASASADGTVRLWdlATGLLLRTLTGHTGAVRSVafSPDGKTLASGSADGTVRLWD----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 874 clktyaikraalsssskglllednpsiraislghghilvgTKNGEILEidksgpmTLlvQGHmEGEVWGLAAHP---LLp 950
Cdd:COG2319 149 ----------------------------------------LATGKLLR-------TL--TGH-SGAVTSVAFSPdgkLL- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 951 vcATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFS 1030
Cdd:COG2319 178 --ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1031 REtGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLqvnsgakeqlffeAPRGKRHVIRIaelekie 1110
Cdd:COG2319 256 PD-GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL-------------ASGSDDGTVRL------- 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1111 WDTWTcvlgPSCEGIWPMHSDVtvVNAATLTKDGTLLATGDDFGFVKLFSYPVKGQHAKFKkyvGHSAQVTNVRWLHNDS 1190
Cdd:COG2319 315 WDLAT----GKLLRTLTGHTGA--VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGR 385
|
490
....*....|....*
gi 2024393284 1191 VLLTvGGADTALMIW 1205
Cdd:COG2319 386 TLAS-GSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
81-375 |
6.30e-25 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 107.04 E-value: 6.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 81 LLAAATGHSDRIFDISWDqYQPNRIVSCGV-KHIKFWTLCGNALtaKRGIFGKTGDLQTILCLACAKEdiTYSGALNGDI 159
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGdGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTY--LASGSSDKTI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 160 YVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTD-FKPITkidlreTEQGYKGlSIRSVCW-KAD 233
Cdd:cd00200 76 RLWdlETGECVRTLTG-HTSYVSSVAFSPDGriLSSSSRDKTIKVWDVEtGKCLT------TLRGHTD-WVNSVAFsPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 234 RLLA-GTQDSEIFEVLVRErDKPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRSVRLWSLADHALIARCN-MEEAVRSV 311
Cdd:cd00200 148 TFVAsSSQDGTIKLWDLRT-GKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSV 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024393284 312 SFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDIYA 375
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
58-292 |
1.20e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 97.41 E-value: 1.20e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 58 QRLASVGLDakNTVCIWDWKRGKLLAAATGHSDRIFDISWDQYqpNRIVSCGVKH--IKFWTL-CGNALTAKRGIFGktg 134
Cdd:cd00200 64 TYLASGSSD--KTIRLWDLETGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVeTGKCLTTLRGHTD--- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 135 dlqTILCLA-CAKEDITYSGALNGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPIT 209
Cdd:cd00200 137 ---WVNSVAfSPDGTFVASSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 210 KIdLRETEQGykglsIRSVCWKADRLL--AGTQDS--EIFEVlvrERDKPMLIMQGHcEGELWALAVHPKKPLAVTGSDD 285
Cdd:cd00200 213 GT-LRGHENG-----VNSVAFSPDGYLlaSGSEDGtiRVWDL---RTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSAD 282
|
....*..
gi 2024393284 286 RSVRLWS 292
Cdd:cd00200 283 GTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1352-1702 |
1.81e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 96.64 E-value: 1.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1352 HTDDILCLTVNQHPKYknIVATSQIGTtptIHVWDamsKQTISMLRCF--HTKGVNYVNFSATGKLLVSVGVDpeHTITV 1429
Cdd:cd00200 8 HTGGVTCVAFSPDGKL--LATGSGDGT---IKVWD---LETGELLRTLkgHTGPVRDVAASADGTYLASGSSD--KTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1430 WRWQEGAKVASRGGHLERIFVVEFRPDSdtQFVSVGVKH--MKFWTLAgsallcKKGVIGSMEDAKMQTMlSVAF-GANN 1506
Cdd:cd00200 78 WDLETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVE------TGKCLTTLRGHTDWVN-SVAFsPDGT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1507 LTFTGAINGDVYVW--KDHFLVRlVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDQEMKRCRAfqletgql 1584
Cdd:cd00200 149 FVASSSQDGTIKLWdlRTGKCVA-TLTGHTGEVNSVAFSPDGEKLLSSS------SDGTIKLWDLSTGKCLG-------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1585 iecvrsVCRGKgkilvgtkdgeilevgeknaasnllidchmEGEIWGLATHPSKDLFISASNDGTARIWDLCDKKLLNKV 1664
Cdd:cd00200 214 ------TLRGH------------------------------ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2024393284 1665 NlGHPAR--CAAYSPDGEMVAIGMKNgefvillvNSLKVW 1702
Cdd:cd00200 258 S-GHTNSvtSLAWSPDGKRLASGSAD--------GTIRIW 288
|
|
| HELP |
pfam03451 |
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ... |
611-654 |
1.11e-20 |
|
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.
Pssm-ID: 460922 Cd Length: 72 Bit Score: 87.61 E-value: 1.11e-20
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 2024393284 611 APEDSLKLQFIHGYRGYDCRNNLFYTQTGEVVYHIAAVAVVYNR 654
Cdd:pfam03451 29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
834-1160 |
1.42e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.16 E-value: 1.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 834 LLKTVKAHDGPVFAMHALDKG--FVTGGKDGIVALWD---DMFERCLKTYAIkraalsssskglllednpSIRAIS-LGH 907
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDletGELLRTLKGHTG------------------PVRDVAaSAD 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 908 GH-ILVGTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPVCATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCC 985
Cdd:cd00200 63 GTyLASGSSDKTIRLWDlETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 986 AFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSrETGKYLAVASHDNFVDIYNVLTSKRVGICKGASS 1065
Cdd:cd00200 142 AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1066 YITHIDWDSRGKLLQvnSGAKEQlffeaprgkrhVIRIaelekieWDTWTCVLGPSCEGiwpmHSdvTVVNAATLTKDGT 1145
Cdd:cd00200 221 GVNSVAFSPDGYLLA--SGSEDG-----------TIRV-------WDLRTGECVQTLSG----HT--NSVTSLAWSPDGK 274
|
330
....*....|....*
gi 2024393284 1146 LLATGDDFGFVKLFS 1160
Cdd:cd00200 275 RLASGSADGTIRIWD 289
|
|
| HELP |
pfam03451 |
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ... |
1289-1340 |
7.27e-13 |
|
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.
Pssm-ID: 460922 Cd Length: 72 Bit Score: 65.27 E-value: 7.27e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2024393284 1289 KNNINKKRKLVEE-LALDHVFGYRGFDCRNNLHYLNDGaDIIFHTAAAGIVQN 1340
Cdd:pfam03451 20 KDDLDQKKEPPDKkLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYD 71
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1621-1654 |
9.08e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 9.08e-04
10 20 30
....*....|....*....|....*....|....
gi 2024393284 1621 IDCHmEGEIWGLATHPSKDLFISASNDGTARIWD 1654
Cdd:smart00320 8 LKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
254-292 |
1.42e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.10 E-value: 1.42e-03
10 20 30
....*....|....*....|....*....|....*....
gi 2024393284 254 KPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRSVRLWS 292
Cdd:pfam00400 2 KLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
1673-1747 |
1.60e-03 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 39.57 E-value: 1.60e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024393284 1673 AAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRD-RKSAIQDIRISPDNRFLAVGSQEHTVDFYDLTQGTTLNRI 1747
Cdd:pfam12894 1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
254-292 |
2.93e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.29 E-value: 2.93e-03
10 20 30
....*....|....*....|....*....|....*....
gi 2024393284 254 KPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRSVRLWS 292
Cdd:smart00320 3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
699-741 |
4.61e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 4.61e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2024393284 699 TLKCLSLLKGqHQRGVCALDFSADGKCLASVGLDDNhaIVFWD 741
Cdd:smart00320 1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGT--IKLWD 40
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
664-965 |
4.71e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 136.31 E-value: 4.71e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 664 GHDDDILSLSIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLASVGLDdnHAIVFWDWK 743
Cdd:cd00200 7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSD--KTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 744 KGEKLATTRGHKDKIFVVKCNPHHvdKLVTVGMKH--IKFWQQTGGGFTSrrgTFgsSGKLETMMSVSYGRIEDLVFSGA 821
Cdd:cd00200 82 TGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVETGKCLT---TL--RGHTDWVNSVAFSPDGTFVASSS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 822 ATGDIFIW--KDTLLLKTVKAHDGPVFAMHALDKG--FVTGGKDGIVALWDDMFERCLKTYAIKRAAlsssskgllledn 897
Cdd:cd00200 155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------- 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024393284 898 psIRAIS-LGHGHILV-GTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPVCATVSDDKTLRIWE 965
Cdd:cd00200 222 --VNSVAfSPDGYLLAsGSEDGTIRVWDlRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
647-1079 |
1.32e-34 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 138.51 E-value: 1.32e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 647 AVAVVYNRQQHSQRLYLGHDDDILSLSIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCL 726
Cdd:COG2319 59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 727 ASVGLDdnHAIVFWDWKKGEKLATTRGHKDKIFVVkcnphhvdklvtvgmkhikfwqqtgggftsrrgTFGSSGKLetmm 806
Cdd:COG2319 136 ASGSAD--GTVRLWDLATGKLLRTLTGHSGAVTSV---------------------------------AFSPDGKL---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 807 svsygriedlVFSGAATGDIFIW--KDTLLLKTVKAHDGPVFAMHALDKG--FVTGGKDGIVALWDdmferclktyaikr 882
Cdd:COG2319 177 ----------LASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGklLASGSADGTVRLWD-------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 883 aalsssskglllednpsiraislghghilvgTKNGEILeidksgpmtLLVQGHmEGEVWGLAAHP---LLpvcATVSDDK 959
Cdd:COG2319 233 -------------------------------LATGKLL---------RTLTGH-SGSVRSVAFSPdgrLL---ASGSADG 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 960 TLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSReTGKYLAV 1039
Cdd:COG2319 269 TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLAS 347
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 2024393284 1040 ASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 1079
Cdd:COG2319 348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
657-1051 |
1.28e-33 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 135.42 E-value: 1.28e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 657 HSQRLYLGHDDDILSLSIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLASVGLDdnHA 736
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASG--SADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GT 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 737 IVFWDWKKGEKLATTRGHKDKIFVVKCNPhhvdklvtvgmkhikfwqqtgggftsrrgtfgsSGKLetmmsvsygriedl 816
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSP---------------------------------DGKL-------------- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 817 VFSGAATGDIFIW--KDTLLLKTVKAHDGPVFAMHALDKG--FVTGGKDGIVALWDdmferclktyaikraalsssskgl 892
Cdd:COG2319 219 LASGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGrlLASGSADGTVRLWD------------------------ 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 893 llednpsiraislghghilvgTKNGEILEidksgpmtlLVQGHmEGEVWGLAAHP---LLpvcATVSDDKTLRIWELSSQ 969
Cdd:COG2319 275 ---------------------LATGELLR---------TLTGH-SGGVNSVAFSPdgkLL---ASGSDDGTVRLWDLATG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 970 HRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSREtGKYLAVASHDNFVDIY 1049
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
|
..
gi 2024393284 1050 NV 1051
Cdd:COG2319 400 DL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
190-531 |
5.11e-31 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 127.72 E-value: 5.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 190 ATGGRDGCIRLWDTDfkpiTKIDLReTEQGYKGlSIRSVCWKAD--RLLAGTQDSEIfEVLVRERDKPMLIMQGHcEGEL 267
Cdd:COG2319 94 ASASADGTVRLWDLA----TGLLLR-TLTGHTG-AVRSVAFSPDgkTLASGSADGTV-RLWDLATGKLLRTLTGH-SGAV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 268 WALAVHPKKPLAVTGSDDRSVRLWSLADHALIARCN-MEEAVRSVSFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDR 346
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 347 KEVIHEMKFSPDGSYLAVGSNDGPVDIYAVAQRyKKIGECNKSSSFITHIDWSVDSKFLQTNDGAGERLFYKMPSGKHLT 426
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 427 nkdEIKGIHWASWTCVIgsevngiwpkytnvtdvnSVDGNYnssvLVTGDDFGLVKLFRfpcLRKGAKFRKYVGHSAHVT 506
Cdd:COG2319 325 ---TLTGHTGAVRSVAF------------------SPDGKT----LASGSDDGTVRLWD---LATGELLRTLTGHTGAVT 376
|
330 340
....*....|....*....|....*
gi 2024393284 507 NVRWSHDFQWVLStGGADHSVFQWQ 531
Cdd:COG2319 377 SVAFSPDGRTLAS-GSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
58-377 |
2.05e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 125.79 E-value: 2.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 58 QRLASVGLDakNTVCIWDWKRGKLLAAATGHSDRIFDISWDqyqPN--RIVSCGV-KHIKFWtlcgNALTAKRgIFGKTG 134
Cdd:COG2319 91 RLLASASAD--GTVRLWDLATGLLLRTLTGHTGAVRSVAFS---PDgkTLASGSAdGTVRLW----DLATGKL-LRTLTG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 135 DLQTILCLAC-AKEDITYSGALNGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDfkpiT 209
Cdd:COG2319 161 HSGAVTSVAFsPDGKLLASGSDDGTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLA----T 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 210 KiDLRETEQGYKGlSIRSVCWKAD--RLLAGTQDSEIfEVLVRERDKPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRS 287
Cdd:COG2319 236 G-KLLRTLTGHSG-SVRSVAFSPDgrLLASGSADGTV-RLWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGT 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 288 VRLWSLADHALIARCNMEEA-VRSVSFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGS 366
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGaVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391
|
330
....*....|.
gi 2024393284 367 NDGPVDIYAVA 377
Cdd:COG2319 392 ADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
15-405 |
2.11e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 125.79 E-value: 2.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 15 PVPQQPVLHSGQGGGLLRGRSRRGLQHPRTQPEILPRAQRRYYQRLASVGLDAKNTVCIWDWKRGKLLAAATGHSDRIFD 94
Cdd:COG2319 4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 95 ISWDQYQPNRIVSCGVKHIKFWTLCGNALTAKRgifgkTGDLQTILCLACAKE-DITYSGALNGDIYVW--KGLNLVRTI 171
Cdd:COG2319 84 VAFSPDGRLLASASADGTVRLWDLATGLLLRTL-----TGHTGAVRSVAFSPDgKTLASGSADGTVRLWdlATGKLLRTL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 172 QGaHSAGIFSMyaceeGF-------ATGGRDGCIRLWDTDfkpitKIDLRETEQGYKGlSIRSVCWKAD--RLLAGTQDS 242
Cdd:COG2319 159 TG-HSGAVTSV-----AFspdgkllASGSDDGTVRLWDLA-----TGKLLRTLTGHTG-AVRSVAFSPDgkLLASGSADG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 243 EI--FEVlvrERDKPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEE-AVRSVSFSPDGSQ 319
Cdd:COG2319 227 TVrlWDL---ATGKLLRTLTGH-SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 320 LALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDIYAVAQRyKKIGECNKSSSFITHIDWS 399
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFS 381
|
....*.
gi 2024393284 400 VDSKFL 405
Cdd:COG2319 382 PDGRTL 387
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1410-1895 |
4.33e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 125.02 E-value: 4.33e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1410 SATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLCKKGVIGSm 1489
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1490 edakmqTMLSVAFGANNLTF-TGAINGDVYVWK-DHFLVRLVAKAHTGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKL 1566
Cdd:COG2319 80 ------AVLSVAFSPDGRLLaSASADGTVRLWDlATGLLLRTLTGHTGAVRSV-AFSPDGkTLASGS------ADGTVRL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1567 WDqemkrcrafqLETGQLIecvrsvcrgkgKILVGtkdgeilevgeknaasnllidcHmEGEIWGLATHPSKDLFISASN 1646
Cdd:COG2319 147 WD----------LATGKLL-----------RTLTG----------------------H-SGAVTSVAFSPDGKLLASGSD 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1647 DGTARIWDLCDKKLLNKVNlGHPA--RCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFL 1724
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLT-GHTGavRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1725 AVGSQEHTVDFYDLTQGTTLNRIGyckDIASFVIQMDFSADSRYIqVSTGAYKRqVHevplgkqITDTATIEKITWATwt 1804
Cdd:COG2319 262 ASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLL-ASGSDDGT-VR-------LWDLATGKLLRTLT-- 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1805 silgdevigiwprnADKADVNCACVTHAGLNIVTGDDFGLVKLFDfpcTEKFAKHKRYFGHSAHVTNIRFSHDDNYVISt 1884
Cdd:COG2319 328 --------------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS- 389
|
490
....*....|.
gi 2024393284 1885 GGDDCSVFVWR 1895
Cdd:COG2319 390 GSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
213-783 |
6.29e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 124.64 E-value: 6.29e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 213 LRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVLVRERDKPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRSVRLWS 292
Cdd:COG2319 28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTVRLWD 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 293 LADHALIARCNM-EEAVRSVSFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPV 371
Cdd:COG2319 107 LATGLLLRTLTGhTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 372 DIYAVAQRyKKIGECNKSSSFITHIDWSVDSKFLqtndgagerlfykmpsgkhltnkdeikgihwaswtcvigsevngiw 451
Cdd:COG2319 187 RLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKLL---------------------------------------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 452 pkytnvtdvnsvdgnynssvlVTGDDFGLVKLFRfpcLRKGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWQ 531
Cdd:COG2319 220 ---------------------ASGSADGTVRLWD---LATGKLLRTLTGHSGSVRSVAFSPDGRLLAS-GSADGTVRLWD 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 532 fipegitngiletapqeggidsyseesdsdlsdvpeldsdieqeaqinydrqvykedlpqlkqqskeknhsvpflkrera 611
Cdd:COG2319 --------------------------------------------------------------------------------
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 612 pedslklqfihgyrgydcrnnlfyTQTGEVVyhiaavavvynrqqhsqRLYLGHDDDILSLSIHPVKDYVATGqvGRDAA 691
Cdd:COG2319 275 ------------------------LATGELL-----------------RTLTGHSGGVNSVAFSPDGKLLASG--SDDGT 311
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 692 IHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLASVGLDdnHAIVFWDWKKGEKLATTRGHKDKIFVVKCNPHHvDKL 771
Cdd:COG2319 312 VRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDD--GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG-RTL 387
|
570
....*....|...
gi 2024393284 772 VTVGM-KHIKFWQ 783
Cdd:COG2319 388 ASGSAdGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1377-1739 |
2.44e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 119.63 E-value: 2.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1377 GTTPTIHVWDAMSKQTISMLRcFHTKGVNYVNFSATGKLLVSVGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPD 1456
Cdd:COG2319 97 SADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1457 SdTQFVSVGV-KHMKFWTLAGSALLckKGVIGSMEDAkmqtmLSVAFGANNLTF-TGAINGDVYVWK-DHFLVRLVAKAH 1533
Cdd:COG2319 174 G-KLLASGSDdGTVRLWDLATGKLL--RTLTGHTGAV-----RSVAFSPDGKLLaSGSADGTVRLWDlATGKLLRTLTGH 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1534 TGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKLWDqemkrcrafqLETGQLIecvrsvcrgkgKILVGTKDGeilevge 1612
Cdd:COG2319 246 SGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGELL-----------RTLTGHSGG------- 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1613 knaasnllidchmegeIWGLATHPSKDLFISASNDGTARIWDLCDKKLLNKVNlGHPA--RCAAYSPDGEMVAIGMKNGE 1690
Cdd:COG2319 291 ----------------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGavRSVAFSPDGKTLASGSDDGT 353
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2024393284 1691 FVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSQEHTVDFYDLT 1739
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
718-1205 |
7.29e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 118.48 E-value: 7.29e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 718 DFSADGKCLASVGLDDNHAIvfWDWKKGEKLATTRGHKDKIFVVKCNPHHVDKLVTVGMKHIKFWQQTGGGFTSRRgtfg 797
Cdd:COG2319 1 ALSADGAALAAASADLALAL--LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL---- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 798 sSGKLETMMSVSYGRIEDLVFSGAATGDIFIW--KDTLLLKTVKAHDGPVFAM--HALDKGFVTGGKDGIVALWDdmfer 873
Cdd:COG2319 75 -LGHTAAVLSVAFSPDGRLLASASADGTVRLWdlATGLLLRTLTGHTGAVRSVafSPDGKTLASGSADGTVRLWD----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 874 clktyaikraalsssskglllednpsiraislghghilvgTKNGEILEidksgpmTLlvQGHmEGEVWGLAAHP---LLp 950
Cdd:COG2319 149 ----------------------------------------LATGKLLR-------TL--TGH-SGAVTSVAFSPdgkLL- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 951 vcATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFS 1030
Cdd:COG2319 178 --ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1031 REtGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLqvnsgakeqlffeAPRGKRHVIRIaelekie 1110
Cdd:COG2319 256 PD-GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL-------------ASGSDDGTVRL------- 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1111 WDTWTcvlgPSCEGIWPMHSDVtvVNAATLTKDGTLLATGDDFGFVKLFSYPVKGQHAKFKkyvGHSAQVTNVRWLHNDS 1190
Cdd:COG2319 315 WDLAT----GKLLRTLTGHTGA--VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGR 385
|
490
....*....|....*
gi 2024393284 1191 VLLTvGGADTALMIW 1205
Cdd:COG2319 386 TLAS-GSADGTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
58-336 |
1.93e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 116.93 E-value: 1.93e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 58 QRLASVGLDakNTVCIWDWKRGKLLAAATGHSDRIFDISWDqyqPN--RIVSCGV-KHIKFWtlcgNALTAKRgIFGKTG 134
Cdd:COG2319 133 KTLASGSAD--GTVRLWDLATGKLLRTLTGHSGAVTSVAFS---PDgkLLASGSDdGTVRLW----DLATGKL-LRTLTG 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 135 DLQTILCLACAKeDITY--SGALNGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKpi 208
Cdd:COG2319 203 HTGAVRSVAFSP-DGKLlaSGSADGTVRLWdlATGKLLRTLTG-HSGSVRSVAFSPDGrlLASGSADGTVRLWDLATG-- 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 209 tkiDLRETEQGYKGlSIRSVCWKAD--RLLAGTQDSEIfEVLVRERDKPMLIMQGHcEGELWALAVHPKKPLAVTGSDDR 286
Cdd:COG2319 279 ---ELLRTLTGHSG-GVNSVAFSPDgkLLASGSDDGTV-RLWDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDG 352
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2024393284 287 SVRLWSLADHALIARCNM-EEAVRSVSFSPDGSQLALGMKDGSFIVLRVRD 336
Cdd:COG2319 353 TVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
81-375 |
6.30e-25 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 107.04 E-value: 6.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 81 LLAAATGHSDRIFDISWDqYQPNRIVSCGV-KHIKFWTLCGNALtaKRGIFGKTGDLQTILCLACAKEdiTYSGALNGDI 159
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGdGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTY--LASGSSDKTI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 160 YVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTD-FKPITkidlreTEQGYKGlSIRSVCW-KAD 233
Cdd:cd00200 76 RLWdlETGECVRTLTG-HTSYVSSVAFSPDGriLSSSSRDKTIKVWDVEtGKCLT------TLRGHTD-WVNSVAFsPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 234 RLLA-GTQDSEIFEVLVRErDKPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRSVRLWSLADHALIARCN-MEEAVRSV 311
Cdd:cd00200 148 TFVAsSSQDGTIKLWDLRT-GKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSV 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024393284 312 SFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDIYA 375
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1340-1702 |
1.95e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 108.07 E-value: 1.95e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1340 NLSTGSQSFYLE-HTDDILCLTVnqHPKYKNIVATSQIGTtptIHVWDAMSKQTISMLRCfHTKGVNYVNFSATGKLLVS 1418
Cdd:COG2319 106 DLATGLLLRTLTgHTGAVRSVAF--SPDGKTLASGSADGT---VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLAS 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1419 VGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTqFVSVGV-KHMKFWTLAGSALLCKKGVIGSmedakmqTM 1497
Cdd:COG2319 180 GSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSAdGTVRLWDLATGKLLRTLTGHSG-------SV 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1498 LSVAFGANNLTF-TGAINGDVYVW--KDHFLVRLVaKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDqemkrc 1574
Cdd:COG2319 250 RSVAFSPDGRLLaSGSADGTVRLWdlATGELLRTL-TGHSGGVNSVAFSPDGKLLASGS------DDGTVRLWD------ 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1575 rafqLETGQLIecvrsvcrgkgKILVGTKDGeilevgeknaasnllidchmegeIWGLATHPSKDLFISASNDGTARIWD 1654
Cdd:COG2319 317 ----LATGKLL-----------RTLTGHTGA-----------------------VRSVAFSPDGKTLASGSDDGTVRLWD 358
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1655 LCDKKLLNKVNlGH--PARCAAYSPDGEMVAIGMKNGefvillvnSLKVW 1702
Cdd:COG2319 359 LATGELLRTLT-GHtgAVTSVAFSPDGRTLASGSADG--------TVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
460-1010 |
2.41e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 101.91 E-value: 2.41e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 460 VNSVDGNYNSSVLVTGDDFGLVKLFRfpcLRKGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWQfipegitn 539
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLAS-GSADGTVRLWD-------- 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 540 giletapqeggidsyseesdsdlsdvpeldsdieqeaqinydrqvykedlpqlkqqskeknhsvpflkrerapedslklq 619
Cdd:COG2319 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 620 fihgyrgydcrnnlfyTQTGEVVYHIAavavvynrqqhsqrlylGHDDDILSLSIHPVKDYVATGqvGRDAAIHVWDTQT 699
Cdd:COG2319 149 ----------------LATGKLLRTLT-----------------GHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLAT 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 700 LKCLSLLKGqHQRGVCALDFSADGKCLASVGLDdnHAIVFWDWKKGEKLATTRGHKDKIFVVkcnphhvdklvtvgmkhi 779
Cdd:COG2319 194 GKLLRTLTG-HTGAVRSVAFSPDGKLLASGSAD--GTVRLWDLATGKLLRTLTGHSGSVRSV------------------ 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 780 kfwqqtgggftsrrgTFGSSGKletmmsvsygriedLVFSGAATGDIFIW--KDTLLLKTVKAHDGPVFAMHALDKG--F 855
Cdd:COG2319 253 ---------------AFSPDGR--------------LLASGSADGTVRLWdlATGELLRTLTGHSGGVNSVAFSPDGklL 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 856 VTGGKDGIVALWDdmferclktyaikraalsssskglllednpsiraislghghilvgTKNGEILEIdksgpmtllVQGH 935
Cdd:COG2319 304 ASGSDDGTVRLWD---------------------------------------------LATGKLLRT---------LTGH 329
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024393284 936 mEGEVWGLAAHPLLPVCATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADT 1010
Cdd:COG2319 330 -TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
662-868 |
2.97e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 98.95 E-value: 2.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 662 YLGHDDDILSLSIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLASVGLDdnHAIVFWD 741
Cdd:cd00200 89 LTGHTSYVSSVAFSPDGRILSSS--SRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQD--GTIKLWD 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 742 WKKGEKLATTRGHKDKIFVVKCNPHHVDKLVTVGMKHIKFWQQTGGGFTsrrGTFgsSGKLETMMSVSYGRIEDLVFSGA 821
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTL--RGHENGVNSVAFSPDGYLLASGS 238
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2024393284 822 ATGDIFIW--KDTLLLKTVKAHDGPVFAM--HALDKGFVTGGKDGIVALWD 868
Cdd:cd00200 239 EDGTIRVWdlRTGECVQTLSGHTNSVTSLawSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
58-331 |
4.98e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 98.56 E-value: 4.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 58 QRLASVGLDakNTVCIWDWKRGKLLAAATGHSDRIFDISWDQYQpNRIVSCGV-KHIKFWTLCGNALTakrGIFgkTGDL 136
Cdd:cd00200 22 KLLATGSGD--GTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSdKTIRLWDLETGECV---RTL--TGHT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 137 QTILCLAC-AKEDITYSGALNGDIYVWKGLN--LVRTIQGaHSAGIFSM-YACEEGFATGG-RDGCIRLWDTD-FKPITK 210
Cdd:cd00200 94 SYVSSVAFsPDGRILSSSSRDKTIKVWDVETgkCLTTLRG-HTDWVNSVaFSPDGTFVASSsQDGTIKLWDLRtGKCVAT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 211 IDlreteqGYKGlSIRSVCWKAD--RLLAGTQDSEIFEVLVRErDKPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRSV 288
Cdd:cd00200 173 LT------GHTG-EVNSVAFSPDgeKLLSSSSDGTIKLWDLST-GKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTI 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2024393284 289 RLWSLADHALIARCNM-EEAVRSVSFSPDGSQLALGMKDGSFIV 331
Cdd:cd00200 244 RVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
58-292 |
1.20e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 97.41 E-value: 1.20e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 58 QRLASVGLDakNTVCIWDWKRGKLLAAATGHSDRIFDISWDQYqpNRIVSCGVKH--IKFWTL-CGNALTAKRGIFGktg 134
Cdd:cd00200 64 TYLASGSSD--KTIRLWDLETGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVeTGKCLTTLRGHTD--- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 135 dlqTILCLA-CAKEDITYSGALNGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPIT 209
Cdd:cd00200 137 ---WVNSVAfSPDGTFVASSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 210 KIdLRETEQGykglsIRSVCWKADRLL--AGTQDS--EIFEVlvrERDKPMLIMQGHcEGELWALAVHPKKPLAVTGSDD 285
Cdd:cd00200 213 GT-LRGHENG-----VNSVAFSPDGYLlaSGSEDGtiRVWDL---RTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSAD 282
|
....*..
gi 2024393284 286 RSVRLWS 292
Cdd:cd00200 283 GTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1352-1702 |
1.81e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 96.64 E-value: 1.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1352 HTDDILCLTVNQHPKYknIVATSQIGTtptIHVWDamsKQTISMLRCF--HTKGVNYVNFSATGKLLVSVGVDpeHTITV 1429
Cdd:cd00200 8 HTGGVTCVAFSPDGKL--LATGSGDGT---IKVWD---LETGELLRTLkgHTGPVRDVAASADGTYLASGSSD--KTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1430 WRWQEGAKVASRGGHLERIFVVEFRPDSdtQFVSVGVKH--MKFWTLAgsallcKKGVIGSMEDAKMQTMlSVAF-GANN 1506
Cdd:cd00200 78 WDLETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVE------TGKCLTTLRGHTDWVN-SVAFsPDGT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1507 LTFTGAINGDVYVW--KDHFLVRlVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDQEMKRCRAfqletgql 1584
Cdd:cd00200 149 FVASSSQDGTIKLWdlRTGKCVA-TLTGHTGEVNSVAFSPDGEKLLSSS------SDGTIKLWDLSTGKCLG-------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1585 iecvrsVCRGKgkilvgtkdgeilevgeknaasnllidchmEGEIWGLATHPSKDLFISASNDGTARIWDLCDKKLLNKV 1664
Cdd:cd00200 214 ------TLRGH------------------------------ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2024393284 1665 NlGHPAR--CAAYSPDGEMVAIGMKNgefvillvNSLKVW 1702
Cdd:cd00200 258 S-GHTNSvtSLAWSPDGKRLASGSAD--------GTIRIW 288
|
|
| HELP |
pfam03451 |
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ... |
611-654 |
1.11e-20 |
|
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.
Pssm-ID: 460922 Cd Length: 72 Bit Score: 87.61 E-value: 1.11e-20
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 2024393284 611 APEDSLKLQFIHGYRGYDCRNNLFYTQTGEVVYHIAAVAVVYNR 654
Cdd:pfam03451 29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
167-405 |
1.69e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.94 E-value: 1.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 167 LVRTIQGaHSAGIFSM--YACEEGFATGGRDGCIRLWDTDFKpitkiDLRETEQGYKGlSIRSVCWKAD--RLLAGTQDS 242
Cdd:cd00200 1 LRRTLKG-HTGGVTCVafSPDGKLLATGSGDGTIKVWDLETG-----ELLRTLKGHTG-PVRDVAASADgtYLASGSSDK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 243 EIFevLVRERDKPML-IMQGHcEGELWALAVHPKKPLAVTGSDDRSVRLWSLADHALIARCNM-EEAVRSVSFSPDGSQL 320
Cdd:cd00200 74 TIR--LWDLETGECVrTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 321 ALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDIYAVAQRyKKIGECNKSSSFITHIDWSV 400
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSP 229
|
....*
gi 2024393284 401 DSKFL 405
Cdd:cd00200 230 DGYLL 234
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1621-1895 |
1.31e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 91.24 E-value: 1.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1621 IDCHmEGEIWGLATHPSKDLFISASNDGTARIWDLCDKKLLnKVNLGH--PARCAAYSPDGEMVAIGMKNgefvillvNS 1698
Cdd:cd00200 5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHtgPVRDVAASADGTYLASGSSD--------KT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1699 LKVW----GKKRDR----KSAIQDIRISPDNRFLAVGSQEHTVDFYDLTQGTTLNRIGYCKDiasFVIQMDFSADSRYiq 1770
Cdd:cd00200 75 IRLWdletGECVRTltghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF-- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1771 VSTGAYKRQVHevplgkqITDTATIEKITwatwtSILGDEvigiwprnadkADVNCACVTHAGLNIVTGDDFGLVKLFDF 1850
Cdd:cd00200 150 VASSSQDGTIK-------LWDLRTGKCVA-----TLTGHT-----------GEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2024393284 1851 pctEKFAKHKRYFGHSAHVTNIRFSHDDNYVIStGGDDCSVFVWR 1895
Cdd:cd00200 207 ---STGKCLGTLRGHENGVNSVAFSPDGYLLAS-GSEDGTIRVWD 247
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
834-1160 |
1.42e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.16 E-value: 1.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 834 LLKTVKAHDGPVFAMHALDKG--FVTGGKDGIVALWD---DMFERCLKTYAIkraalsssskglllednpSIRAIS-LGH 907
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDletGELLRTLKGHTG------------------PVRDVAaSAD 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 908 GH-ILVGTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPVCATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCC 985
Cdd:cd00200 63 GTyLASGSSDKTIRLWDlETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 986 AFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSrETGKYLAVASHDNFVDIYNVLTSKRVGICKGASS 1065
Cdd:cd00200 142 AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1066 YITHIDWDSRGKLLQvnSGAKEQlffeaprgkrhVIRIaelekieWDTWTCVLGPSCEGiwpmHSdvTVVNAATLTKDGT 1145
Cdd:cd00200 221 GVNSVAFSPDGYLLA--SGSEDG-----------TIRV-------WDLRTGECVQTLSG----HT--NSVTSLAWSPDGK 274
|
330
....*....|....*
gi 2024393284 1146 LLATGDDFGFVKLFS 1160
Cdd:cd00200 275 RLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
902-1205 |
1.64e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.16 E-value: 1.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 902 AISLGHGHILVGTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPVCATVSDDKTLRIWELSSQHRmlaVRKL-- 978
Cdd:cd00200 16 AFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC---VRTLtg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 979 -KKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSrETGKYLAVASHDNFVDIYNVLTSKRV 1057
Cdd:cd00200 92 hTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS-PDGTFVASSSQDGTIKLWDLRTGKCV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1058 GICKGASSYITHIDWDSRGKLLQVNSGAKeqlffeaprgkrhVIRIaelekieWDTWTCVLGPSCEGiwpmHSDvtVVNA 1137
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDG-------------TIKL-------WDLSTGKCLGTLRG----HEN--GVNS 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024393284 1138 ATLTKDGTLLATGDDFGFVKLFSYPVKGQHAKFKkyvGHSAQVTNVRWlHNDSVLLTVGGADTALMIW 1205
Cdd:cd00200 225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS---GHTNSVTSLAW-SPDGKRLASGSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1588-1895 |
1.70e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 85.08 E-value: 1.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1588 VRSVC--RGKGKILVGTKDGEILEVgekNAASNLLIDC---HmEGEIWGLATHPSKDLFISASNDGTARIWDLCDKKLLN 1662
Cdd:cd00200 12 VTCVAfsPDGKLLATGSGDGTIKVW---DLETGELLRTlkgH-TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1663 KVNlGHPA--RCAAYSPDGEMVAIGMKNGefvillvnSLKVW----GKK----RDRKSAIQDIRISPDNRFLAVGSQEHT 1732
Cdd:cd00200 88 TLT-GHTSyvSSVAFSPDGRILSSSSRDK--------TIKVWdvetGKClttlRGHTDWVNSVAFSPDGTFVASSSQDGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1733 VDFYDLTQGTTLNRI-GYCKDIASfviqMDFSADSRyiQVSTGAYKRQ--VHEVPLGKQItdtATIEkitwatwtsilgd 1809
Cdd:cd00200 159 IKLWDLRTGKCVATLtGHTGEVNS----VAFSPDGE--KLLSSSSDGTikLWDLSTGKCL---GTLR------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1810 evigiwprnADKADVNCACVTHAGLNIVTGDDFGLVKLFDfpcTEKFAKHKRYFGHSAHVTNIRFSHDDNYVIStGGDDC 1889
Cdd:cd00200 217 ---------GHENGVNSVAFSPDGYLLASGSEDGTIRVWD---LRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADG 283
|
....*.
gi 2024393284 1890 SVFVWR 1895
Cdd:cd00200 284 TIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
260-531 |
4.68e-16 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 80.84 E-value: 4.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 260 QGHcEGELWALAVHPKKPLAVTGSDDRSVRLWSLADHALIAR-CNMEEAVRSVSFSPDGSQLALGMKDGSFIVLRVRDMT 338
Cdd:cd00200 6 KGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 339 EVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDIYAVAQrYKKIGECNKSSSFITHIDWSVDSKFLQT--NDGAGerLF 416
Cdd:cd00200 85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASssQDGTI--KL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 417 YKMPSGKHL-TNKDEIKGIHWASWTcvigsevngiwPKytnvtdvnsvdgnyNSSVLVTGDDfGLVKLFRfpcLRKGAKF 495
Cdd:cd00200 162 WDLRTGKCVaTLTGHTGEVNSVAFS-----------PD--------------GEKLLSSSSD-GTIKLWD---LSTGKCL 212
|
250 260 270
....*....|....*....|....*....|....*.
gi 2024393284 496 RKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWQ 531
Cdd:cd00200 213 GTLRGHENGVNSVAFSPDGYLLAS-GSEDGTIRVWD 247
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1337-1568 |
1.00e-15 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 79.69 E-value: 1.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1337 IVQNLSTGSQSFYLE-HTDDILCLTVNQHPKYknIVATSQIGttpTIHVWDAMSKQTISMLRCfHTKGVNYVNFSATGKL 1415
Cdd:cd00200 76 RLWDLETGECVRTLTgHTSYVSSVAFSPDGRI--LSSSSRDK---TIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTF 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1416 LVSVGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLCkkgVIGSMEDAkmq 1495
Cdd:cd00200 150 VASSSQD--GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG---TLRGHENG--- 221
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024393284 1496 tMLSVAFGANNLTFTGA-INGDVYVWK-DHFLVRLVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWD 1568
Cdd:cd00200 222 -VNSVAFSPDGYLLASGsEDGTIRVWDlRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS------ADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1443-1737 |
4.06e-15 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 78.15 E-value: 4.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1443 GHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLA-GSALLCKKGVIGSMEDAkmqtmLSVAFGanNLTFTGAINGDVYVW- 1520
Cdd:cd00200 7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDV-----AASADG--TYLASGSSDKTIRLWd 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1521 --KDHFLVRLvaKAHTGPVFTMyTTLRDGLIVTGGkerptKEGGAVKLWDQEMKRCRAFQLETGQLIECVRsVCRGKGKI 1598
Cdd:cd00200 80 leTGECVRTL--TGHTSYVSSV-AFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVA-FSPDGTFV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1599 LVGTKDGEI----LEVGEKNAasnlLIDCHmEGEIWGLATHPSKDLFISASNDGTARIWDLCDKKLLnKVNLGH--PARC 1672
Cdd:cd00200 151 ASSSQDGTIklwdLRTGKCVA----TLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL-GTLRGHenGVNS 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024393284 1673 AAYSPDGEMVAIGMKNGefvillvnSLKVW-GKKRDRK-------SAIQDIRISPDNRFLAVGSQEHTVDFYD 1737
Cdd:cd00200 225 VAFSPDGYLLASGSEDG--------TIRVWdLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
460-765 |
2.62e-14 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 75.45 E-value: 2.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 460 VNSVDGNYNSSVLVTGDDFGLVKLFRfpcLRKGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWQFIpegiTN 539
Cdd:cd00200 12 VTCVAFSPDGKLLATGSGDGTIKVWD---LETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLWDLE----TG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 540 GILETapQEGgidsyseesdsDLSDVpeLDSDIEQEAQI----NYDRQVYKEDLPQLKQQSKEKNHsvpflkrerapEDS 615
Cdd:cd00200 84 ECVRT--LTG-----------HTSYV--SSVAFSPDGRIlsssSRDKTIKVWDVETGKCLTTLRGH-----------TDW 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 616 LklqfihgyrgydcrNNLFYTQTGEVVYHIAA--VAVVYN-RQQHSQRLYLGHDDDILSLSIHPVKDYVATGqvGRDAAI 692
Cdd:cd00200 138 V--------------NSVAFSPDGTFVASSSQdgTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS--SSDGTI 201
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024393284 693 HVWDTQTLKCLSLLKGqHQRGVCALDFSADGKcLASVGLDDNHaIVFWDWKKGEKLATTRGHKDKIFVVKCNP 765
Cdd:cd00200 202 KLWDLSTGKCLGTLRG-HENGVNSVAFSPDGY-LLASGSEDGT-IRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
|
|
| HELP |
pfam03451 |
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ... |
1289-1340 |
7.27e-13 |
|
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.
Pssm-ID: 460922 Cd Length: 72 Bit Score: 65.27 E-value: 7.27e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2024393284 1289 KNNINKKRKLVEE-LALDHVFGYRGFDCRNNLHYLNDGaDIIFHTAAAGIVQN 1340
Cdd:pfam03451 20 KDDLDQKKEPPDKkLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYD 71
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
979-1205 |
1.79e-12 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 70.06 E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 979 KKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSReTGKYLAVASHDNFVDIYNVLTSKRVG 1058
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1059 ICKGASSYITHIDWDSRGKLLqvnSGAKEQlffeaprgkrHVIRIaelekieWDTWTCVLGPSCEGiwpmHSDvtVVNAA 1138
Cdd:cd00200 88 TLTGHTSYVSSVAFSPDGRIL---SSSSRD----------KTIKV-------WDVETGKCLTTLRG----HTD--WVNSV 141
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024393284 1139 TLTKDGTLLATGDDFGFVKLFSyPVKGQHakFKKYVGHSAQVTNVRWlHNDSVLLTVGGADTALMIW 1205
Cdd:cd00200 142 AFSPDGTFVASSSQDGTIKLWD-LRTGKC--VATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLW 204
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
307-405 |
6.98e-04 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 44.64 E-value: 6.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 307 AVRSVSFSPDGSQLA-LGMKDGSF-IVLR--VRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDIYAVA-QRYK 381
Cdd:COG4946 344 RERLPAWSPDGKSIAyFSDASGEYeLYIApaDGSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLAsGKVR 423
|
90 100
....*....|....*....|....
gi 2024393284 382 KIGECNKSSSFIThIDWSVDSKFL 405
Cdd:COG4946 424 KVDTDGYGDGISD-LAWSPDSKWL 446
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1621-1654 |
9.08e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 9.08e-04
10 20 30
....*....|....*....|....*....|....
gi 2024393284 1621 IDCHmEGEIWGLATHPSKDLFISASNDGTARIWD 1654
Cdd:smart00320 8 LKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
1638-1769 |
9.46e-04 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 42.76 E-value: 9.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1638 KDLFISASNDGTARIWDLCDKKLLNKVNLGHPARCAAYSPDGEMVAI-GMKNGEFVILLVNSLKVWGKKRDRKSAiQDIR 1716
Cdd:COG3391 80 RRLYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVaDSGNGRVSVIDTATGKVVATIPVGAGP-HGIA 158
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2024393284 1717 ISPDNRFLAVGSQE-HTVDFY----DLTQGTTLNRIgyckDIASFVIQMDFSADSRYI 1769
Cdd:COG3391 159 VDPDGKRLYVANSGsNTVSVIvsviDTATGKVVATI----PVGGGPVGVAVSPDGRRL 212
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1855-1894 |
1.01e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 1.01e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2024393284 1855 KFAKHKRYFGHSAHVTNIRFSHDDNYVIStGGDDCSVFVW 1894
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLAS-GSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
254-292 |
1.42e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.10 E-value: 1.42e-03
10 20 30
....*....|....*....|....*....|....*....
gi 2024393284 254 KPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRSVRLWS 292
Cdd:pfam00400 2 KLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
1673-1747 |
1.60e-03 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 39.57 E-value: 1.60e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024393284 1673 AAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRD-RKSAIQDIRISPDNRFLAVGSQEHTVDFYDLTQGTTLNRI 1747
Cdd:pfam12894 1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1621-1654 |
1.68e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.71 E-value: 1.68e-03
10 20 30
....*....|....*....|....*....|....
gi 2024393284 1621 IDCHmEGEIWGLATHPSKDLFISASNDGTARIWD 1654
Cdd:pfam00400 7 LEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1860-1894 |
2.00e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.71 E-value: 2.00e-03
10 20 30
....*....|....*....|....*....|....*
gi 2024393284 1860 KRYFGHSAHVTNIRFSHDDNYVIStGGDDCSVFVW 1894
Cdd:pfam00400 5 KTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
254-292 |
2.93e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.29 E-value: 2.93e-03
10 20 30
....*....|....*....|....*....|....*....
gi 2024393284 254 KPMLIMQGHcEGELWALAVHPKKPLAVTGSDDRSVRLWS 292
Cdd:smart00320 3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| 8prop_heme_binding_protein |
cd20718 |
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ... |
1631-1815 |
3.25e-03 |
|
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.
Pssm-ID: 467720 [Multi-domain] Cd Length: 380 Bit Score: 41.94 E-value: 3.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1631 GLATHPSKDLFISASNDGTARIWDLCDKKLLNKVNLGHPARCAAYSPDGEMVAIGMKN-GEFVILLVNSLKV-------- 1701
Cdd:cd20718 63 VVVFSPDGRFAYVISRDGWLTKIDLYTLRPVASIRIGVNSRGIALSDDGKYVIAGNYEpGHVVILDADTLEPlkvipttg 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 1702 ---WGKKRDRKSAIQDirISPDNRFLAVGSQEHTVDFYDLTQGTTlNRIGYCKDIASFVIQMDFSADSRYIQVSTGA--- 1775
Cdd:cd20718 143 vndDGIIESRVGAILE--TPPGPYFLVALKDAGSVWVIDYSDPDG-NKVTDIGNIGRPLHDAFLDPDGRYFIVASQGsnt 219
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2024393284 1776 -------YKRQVHEVPLGKQI-TDTATIEKITWATWTSILGDEVIGIW 1815
Cdd:cd20718 220 mwvldlkTGKVVARIPTGKTPhPGPGATWGRKGVTATPHLGEGIVTVW 267
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
699-741 |
4.61e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 4.61e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2024393284 699 TLKCLSLLKGqHQRGVCALDFSADGKCLASVGLDDNhaIVFWD 741
Cdd:smart00320 1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGT--IKLWD 40
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
278-376 |
5.98e-03 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 39.27 E-value: 5.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024393284 278 LAVTGSDDRSVRLW--SLADHALIARCNMEEAVRSVSFSPDGSQLAL-GMKDGSFIVLRVR-DMTEVVHIKDRKEVIHEM 353
Cdd:COG0823 1 LAFTLSRDGNSDIYvvDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFtSDRGGGPQIYVVDaDGGEPRRLTFGGGYNASP 80
|
90 100
....*....|....*....|....
gi 2024393284 354 KFSPDGSYLAVGSN-DGPVDIYAV 376
Cdd:COG0823 81 SWSPDGKRLAFVSRsDGRFDIYVL 104
|
|
| |
