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Conserved domains on  [gi|2024410608|ref|XP_040557142|]
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zinc finger protein 143 isoform X1 [Gallus gallus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-438 7.19e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.43  E-value: 7.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 265 AHHLKVHERSHTGdRPYQCEHPGCGKAFATGYGLKSHIRT--HTGE--KPYRCTEENCTKSFKTSGDLQKHIRTHTGERP 340
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 341 FKCPFEGCGRSFTTSNIRK-----VHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 415
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 2024410608 416 SSLYKHHVVHTHSKPYNCNHCGK 438
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-438 7.19e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.43  E-value: 7.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 265 AHHLKVHERSHTGdRPYQCEHPGCGKAFATGYGLKSHIRT--HTGE--KPYRCTEENCTKSFKTSGDLQKHIRTHTGERP 340
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 341 FKCPFEGCGRSFTTSNIRK-----VHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 415
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 2024410608 416 SSLYKHHVVHTHSKPYNCNHCGK 438
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 283-370 4.32e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 45.49  E-value: 4.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 283 CEHPGCGKAFATGYGLKSHIRTHTGE------KPYRCTEENCTKSFKTSGDLQKHIRTH-TGERPFKCpfEGCGRSFTT- 354
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTh 79

                          90
                  ....*....|....*..
gi 2024410608 355 -SNIRKVHIRTHTGERP 370
Cdd:pfam15909  80 rSLFKHLHVCAEHAQSP 96
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-438 7.19e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.43  E-value: 7.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 265 AHHLKVHERSHTGdRPYQCEHPGCGKAFATGYGLKSHIRT--HTGE--KPYRCTEENCTKSFKTSGDLQKHIRTHTGERP 340
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 341 FKCPFEGCGRSFTTSNIRK-----VHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 415
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 2024410608 416 SSLYKHHVVHTHSKPYNCNHCGK 438
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
369-444 5.11e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.11e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024410608 369 RPYYCtePGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQIS 444
Cdd:COG5048    32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 263-427 5.16e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 55.49  E-value: 5.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 263 TTAHHLKVHERSHTGDrpYQCEHPGcgkafATGYGLKSHIRTHTGEKPYRCTEENCTKSFKTSGDLQKHIRTHT------ 336
Cdd:COG5189   273 SQGSAELFEESSLGFD--YEFIHKS-----VGNKEIRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSrmlkvk 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 337 GERPFKCPFEGCGRSFTTSNIRKVH-IRTHTGERPYYCTEPGCGRAFASAtnyknhvrihtgEKPYVCTVpgCDKRFTEY 415
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                         170
                  ....*....|..
gi 2024410608 416 SSLyKHHVVHTH 427
Cdd:COG5189   412 NGL-KYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 397-454 5.98e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 55.49  E-value: 5.98e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024410608 397 GEKPYVCTVPGCDKRFTEYSSLyKHHVVHTH--------------------SKPYNCNHCGKTYKQISTLAMHKRTAH 454
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHqnqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-422 1.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 246 SGEKAFRCDYDGCGKLYTTAHHLKVHERSHTGDRPYQCEhpgcgkafatgygLKSHIRTHTGEKPYrcteenctksfKTS 325
Cdd:COG5048   317 ESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEK-------------LLNSSSKFSPLLNN-----------EPP 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 326 GDLQKHIRTHTgERPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCtv 405
Cdd:COG5048   373 QSLQQYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-- 449

                         170
                  ....*....|....*..
gi 2024410608 406 pgCDKRFTEYSSLYKHH 422
Cdd:COG5048   450 --SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-336 1.56e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.56e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024410608 278 DRPYQCehPGCGKAFATGYGLKSHIRTHTGEKPYRCTEENCTKSFKTSGDLQKHIRTHT 336
Cdd:COG5048    31 PRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 283-370 4.32e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 45.49  E-value: 4.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 283 CEHPGCGKAFATGYGLKSHIRTHTGE------KPYRCTEENCTKSFKTSGDLQKHIRTH-TGERPFKCpfEGCGRSFTT- 354
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTh 79

                          90
                  ....*....|....*..
gi 2024410608 355 -SNIRKVHIRTHTGERP 370
Cdd:pfam15909  80 rSLFKHLHVCAEHAQSP 96
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
373-456 8.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 8.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 373 CTEPGCGRAFASATNYKNHVR--IHTGE--KPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNC--NHCGKTYKQIST- 445
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNn 369

                          90
                  ....*....|....*
gi 2024410608 446 ----LAMHKRTAHND 456
Cdd:COG5048   370 eppqSLQQYKDLKND 384
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-354 1.08e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.08e-05
                          10        20
                  ....*....|....*....|....*...
gi 2024410608 327 DLQKHIRTHTGERPFKCPFegCGRSFTT 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-324 1.25e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.25e-05
                          10        20
                  ....*....|....*....|....*..
gi 2024410608 298 LKSHIRTHTGEKPYRCTEenCTKSFKT 324
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
309-459 4.63e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 4.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 309 KPYRCteENCTKSFKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHIRTHTgERPYYCTEPGCGRAFASATNY 388
Cdd:COG5048    32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH-NNPSDLNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024410608 389 KNHvrIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHS---KPYNCNHCGKTYKQISTLAMHKRTAHNDTEP 459
Cdd:COG5048   109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLrnnPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP 180
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-294 1.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*...
gi 2024410608 267 HLKVHERSHTGDRPYQCehPGCGKAFAT 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-413 1.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.60e-04
                          10        20
                  ....*....|....*....|....*..
gi 2024410608 387 NYKNHVRIHTGEKPYVCTVpgCDKRFT 413
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 247-306 3.69e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024410608 247 GEKAFRCDYDGCGKLYTTAHHLKVH---------------ERSHTG----DRPYQCEHpgCGKAFATGYGLKSHiRTHT 306
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 311-335 1.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.37e-03
                          10        20
                  ....*....|....*....|....*
gi 2024410608 311 YRCTEenCTKSFKTSGDLQKHIRTH 335
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-384 1.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.82e-03
                          10        20
                  ....*....|....*....|....*.
gi 2024410608 359 KVHIRTHTGERPYYCTEpgCGRAFAS 384
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 313-429 2.08e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.17  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 313 CTEENCTKSFKTSGDLQKHIRTHTgerPFKCPFEGcgrsfttsnirkvhirthtgeRPYYCTEPGCGRAFASATNYKNHV 392
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHC---PPTQSLEG---------------------KLFRCSALSCTETFPSMQELVAHS 57

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2024410608 393 RIHTGEKPYVcTVPGCDKRFTEYSSLYKH-HVVHTHSK 429
Cdd:pfam15909  58 KLHYKPNRYF-KCENCLLRFRTHRSLFKHlHVCAEHAQ 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-472 2.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 248 EKAFRCDY-DGCGKLYTTAHHLKVHERSHTGDRPYQCEHPGCGKAFATGYGLKSHIRTHTGEKPYRCTEENCTKSFKTSG 326
Cdd:COG5048    28 SNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 327 DL----------------------QKHIRTHTGERP---FKCPFEGCGRSFT----TSNIRKVHIRTHTGERPYYCTEPG 377
Cdd:COG5048   108 SSlsssssnsndnnllsshslppsSRDPQLPDLLSIsnlRNNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024410608 378 CGRAFASA--TNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHS---------KPYNCNHCGKTYKQISTL 446
Cdd:COG5048   188 ISSNVSTSipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsslsSSDSSSSASESPRSSLPT 267

                         250       260
                  ....*....|....*....|....*.
gi 2024410608 447 AMHKRTAHNDTEpiEEEQEAFFEPPP 472
Cdd:COG5048   268 ASSQSSSPNESD--SSSEKGFSLPIK 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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