|
Name |
Accession |
Description |
Interval |
E-value |
| TBC |
smart00164 |
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ... |
96-302 |
3.83e-61 |
|
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.
Pssm-ID: 214540 [Multi-domain] Cd Length: 216 Bit Score: 204.46 E-value: 3.83e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 96 VYKGIPLQVRGQVWSLLLDVEKMK-KENEGKYEQMKQQ-AKSWSSEIKQIDLDVNRTFRNHIMFRDRYGVKQQALFHVLS 173
Cdd:smart00164 1 VRKGVPPSLRGVVWKLLLNAQPMDtSADKDLYSRLLKEtAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQESLRRVLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 174 AYSVYNTEVSYCQGMSQIAAILLMYL-NEEDAFWALAQLLtnqKHAMHGFFIPGFPKLQRFQAHHEQILSKLFPKLKKHM 252
Cdd:smart00164 81 AYALYNPEVGYCQGMNFLAAPLLLVMeDEEDAFWCLVKLM---ERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHL 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2024412791 253 DKEQMTTGIYTTKWFLQCFIDRTPFTLTLRLWDIYILEGERVLTAMAYTI 302
Cdd:smart00164 158 KDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALAL 207
|
|
| RabGAP-TBC |
pfam00566 |
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ... |
136-294 |
1.80e-55 |
|
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Pssm-ID: 459855 Cd Length: 178 Bit Score: 187.85 E-value: 1.80e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 136 WSSeikQIDLDVNRTFRNHIMFRDRYGvkQQALFHVLSAYSVYNTEVSYCQGMSQIAAILLM-YLNEEDAFWALAQLLTN 214
Cdd:pfam00566 8 WPE---QIEKDVPRTFPHSFFFDNGPG--QNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLvYLDEEDAFWCFVSLLEN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 215 QKhaMHGFFIPGFPKLQRFQAHHEQILSKLFPKLKKHMDKEQMTTGIYTTKWFLQCFIDRTPFTLTLRLWDIYILEGERV 294
Cdd:pfam00566 83 YL--LRDFYTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKF 160
|
|
| COG5210 |
COG5210 |
GTPase-activating protein [General function prediction only]; |
51-302 |
2.63e-47 |
|
GTPase-activating protein [General function prediction only];
Pssm-ID: 227535 [Multi-domain] Cd Length: 496 Bit Score: 175.38 E-value: 2.63e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 51 HEQELPTRTALEEKQKQQEIERVDKWLKMLKKWGKYR---NSDKMCRRVYKGIPLQVRGQVWSLLLDVEKMKKENEGKYE 127
Cdd:COG5210 161 KEINELSLKEEPQKLRYYELAADKLWISYLDPNPLSFlpvQLSKLRELIRKGIPNELRGDVWEFLLGIGFDLDKNPGLYE 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 128 Q----MKQQAKSWSSEIKQIDLDVNRTFRNHIMFRDRYGVKQQALFHVLSAYSVYNTEVSYCQGMSQIAAILLMYL-NEE 202
Cdd:COG5210 241 RllnlHREAKIPTQEIISQIEKDLSRTFPDNSLFQTEISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLeSEE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 203 DAFWALAQLLtnQKHAMHGFFIPGFPKLQRFQAHHEQILSKLFPKLKKHMDKEQMTTGIYTTKWFLQCFIDRTPFTLTLR 282
Cdd:COG5210 321 QAFWCLVKLL--KNYGLPGYFLKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALR 398
|
250 260
....*....|....*....|
gi 2024412791 283 LWDIYILEGERVLTAMAYTI 302
Cdd:COG5210 399 IWDCLFLEGSSMLFQLALAI 418
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
356-555 |
5.37e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 50.17 E-value: 5.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 356 PPPAKPDEFPRKPLGLELSLNPLATKANAAANGQNGLLGeHPSDRGTAQPPSHQGTAARTPDVPGSQAHEAADSH--PHP 433
Cdd:PHA03307 127 PPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASD-AASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAaaSPR 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 434 PQSEGQPTEDVAQRQSPKPSEMQAFPASLEDAVGSGEPTLNAGHGVEHDDHREPHHKPPSPTPSLCSSVGS-----FHPA 508
Cdd:PHA03307 206 PPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNgpssrPGPA 285
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2024412791 509 SNAPVDAPAGEAQPPEQPSSMDHTPDPAACGPSEDQQASSLPGEEAT 555
Cdd:PHA03307 286 SSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS 332
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
355-551 |
3.86e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.99 E-value: 3.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 355 LPPPAKPDEFPRKPLGLELSLNPLATKANAAANGQNGLlgEHPsdrGTAQP--PSHQGTAARTPDVPGSQAHEAADSHPH 432
Cdd:pfam03154 252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHM--QHP---VPPQPfpLTPQSSQSQVPPGPSPAAPGQSQQRIH 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 433 PPQSEGQPTEDVAQRQSPKPSEMQAFPaSLEDAVGSGEPTLNAGHGVEHDDH-------REPHHKPPSPTPSLCSSVGSF 505
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPAPLSMP-HIKPPPTTPIPQLPNPQSHKHPPHlsgpspfQMNSNLPPPPALKPLSSLSTH 405
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2024412791 506 HPASNAPVD---APAGE--AQPPEQPSSMDHTPDPAACGPSEDQQASSLPG 551
Cdd:pfam03154 406 HPPSAHPPPlqlMPQSQqlPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQV 456
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| TBC |
smart00164 |
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ... |
96-302 |
3.83e-61 |
|
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.
Pssm-ID: 214540 [Multi-domain] Cd Length: 216 Bit Score: 204.46 E-value: 3.83e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 96 VYKGIPLQVRGQVWSLLLDVEKMK-KENEGKYEQMKQQ-AKSWSSEIKQIDLDVNRTFRNHIMFRDRYGVKQQALFHVLS 173
Cdd:smart00164 1 VRKGVPPSLRGVVWKLLLNAQPMDtSADKDLYSRLLKEtAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQESLRRVLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 174 AYSVYNTEVSYCQGMSQIAAILLMYL-NEEDAFWALAQLLtnqKHAMHGFFIPGFPKLQRFQAHHEQILSKLFPKLKKHM 252
Cdd:smart00164 81 AYALYNPEVGYCQGMNFLAAPLLLVMeDEEDAFWCLVKLM---ERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHL 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2024412791 253 DKEQMTTGIYTTKWFLQCFIDRTPFTLTLRLWDIYILEGERVLTAMAYTI 302
Cdd:smart00164 158 KDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALAL 207
|
|
| RabGAP-TBC |
pfam00566 |
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ... |
136-294 |
1.80e-55 |
|
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Pssm-ID: 459855 Cd Length: 178 Bit Score: 187.85 E-value: 1.80e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 136 WSSeikQIDLDVNRTFRNHIMFRDRYGvkQQALFHVLSAYSVYNTEVSYCQGMSQIAAILLM-YLNEEDAFWALAQLLTN 214
Cdd:pfam00566 8 WPE---QIEKDVPRTFPHSFFFDNGPG--QNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLvYLDEEDAFWCFVSLLEN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 215 QKhaMHGFFIPGFPKLQRFQAHHEQILSKLFPKLKKHMDKEQMTTGIYTTKWFLQCFIDRTPFTLTLRLWDIYILEGERV 294
Cdd:pfam00566 83 YL--LRDFYTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKF 160
|
|
| COG5210 |
COG5210 |
GTPase-activating protein [General function prediction only]; |
51-302 |
2.63e-47 |
|
GTPase-activating protein [General function prediction only];
Pssm-ID: 227535 [Multi-domain] Cd Length: 496 Bit Score: 175.38 E-value: 2.63e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 51 HEQELPTRTALEEKQKQQEIERVDKWLKMLKKWGKYR---NSDKMCRRVYKGIPLQVRGQVWSLLLDVEKMKKENEGKYE 127
Cdd:COG5210 161 KEINELSLKEEPQKLRYYELAADKLWISYLDPNPLSFlpvQLSKLRELIRKGIPNELRGDVWEFLLGIGFDLDKNPGLYE 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 128 Q----MKQQAKSWSSEIKQIDLDVNRTFRNHIMFRDRYGVKQQALFHVLSAYSVYNTEVSYCQGMSQIAAILLMYL-NEE 202
Cdd:COG5210 241 RllnlHREAKIPTQEIISQIEKDLSRTFPDNSLFQTEISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLeSEE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 203 DAFWALAQLLtnQKHAMHGFFIPGFPKLQRFQAHHEQILSKLFPKLKKHMDKEQMTTGIYTTKWFLQCFIDRTPFTLTLR 282
Cdd:COG5210 321 QAFWCLVKLL--KNYGLPGYFLKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALR 398
|
250 260
....*....|....*....|
gi 2024412791 283 LWDIYILEGERVLTAMAYTI 302
Cdd:COG5210 399 IWDCLFLEGSSMLFQLALAI 418
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
356-555 |
5.37e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 50.17 E-value: 5.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 356 PPPAKPDEFPRKPLGLELSLNPLATKANAAANGQNGLLGeHPSDRGTAQPPSHQGTAARTPDVPGSQAHEAADSH--PHP 433
Cdd:PHA03307 127 PPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASD-AASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAaaSPR 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 434 PQSEGQPTEDVAQRQSPKPSEMQAFPASLEDAVGSGEPTLNAGHGVEHDDHREPHHKPPSPTPSLCSSVGS-----FHPA 508
Cdd:PHA03307 206 PPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNgpssrPGPA 285
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2024412791 509 SNAPVDAPAGEAQPPEQPSSMDHTPDPAACGPSEDQQASSLPGEEAT 555
Cdd:PHA03307 286 SSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS 332
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
356-740 |
1.21e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 356 PPPAKPDEFPRKPLGLELSLNPLATKANAAANGQNGLLGEHPSDRGTAQPPSHQGTAARTPDVPGSQAHEAADSHPHPPQ 435
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP 2705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 436 SEGQPTEDVAQRQSPKP----SEMQAFPASLEDAVGSGEPTLNAGHGVEHDDHREPHHK-PPSPTPSlCSSVGSFHPASN 510
Cdd:PHA03247 2706 PTPEPAPHALVSATPLPpgpaAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgPPAPAPP-AAPAAGPPRRLT 2784
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 511 APVDAPAGEAQPpEQPSSMDHTPDPAACGPSedqqASSLPGEEATAlhrdipedigetqhgvlllNGMDSKASLPKSASA 590
Cdd:PHA03247 2785 RPAVASLSESRE-SLPSPWDPADPPAAVLAP----AAALPPAASPA-------------------GPLPPPTSAQPTAPP 2840
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 591 GELGGLQQSTEMAleqgftalGSLAPCRPSGSSTPilSESVALARGNSLHTVVKTTTRLHVAQVTEQdlanrrqVALPWP 670
Cdd:PHA03247 2841 PPPGPPPPSLPLG--------GSVAPGGDVRRRPP--SRSPAAKPAAPARPPVRRLARPAVSRSTES-------FALPPD 2903
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 671 EAAHPLAATSLLPPATSDTGAVQQGTQKPLNALKAPRPPLSPKPKLPPQVSKSLSENNFSPGSLPPARLP 740
Cdd:PHA03247 2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVA 2973
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
394-554 |
1.27e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.83 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 394 GEHPSDRGTAQPPSHQGTAARTPDVPGSQAHEAADSHPHPPQSEGQPTEdvaqrQSPKPSEMQAFPASLEDAVGSGEPTL 473
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAE-----ASAAPAPGVAAPEHHPKHVAVPDASD 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 474 NAGHGVEHDDHREPHHKPPSPTPSlcssvgsfHPASNAPVDAPAGEAQPPEQPSSmDHTPDPAACGPSEDQQASSLPGEE 553
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAPPPAPAPA--------APAAPAGAAPAQPAPAPAATPPA-GQADDPAAQPPQAAQGASAPSPAA 735
|
.
gi 2024412791 554 A 554
Cdd:PRK07764 736 D 736
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
377-541 |
5.37e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 46.77 E-value: 5.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 377 PLATKANAAANGQNGLLGEHPSDRGTAQPPSHQGTAARTPDVPgsqahEAADSHPHPPQSEGQPTEDVAQRQS-PKPSEM 455
Cdd:PRK07003 381 PAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRA-----EAPPAAPAPPATADRGDDAADGDAPvPAKANA 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 456 QAFPASLEDAVGSGEPTLNAGHGVEHDDHREPHHKPPSPTPSLCSSVGSFHPASNAPVDAPA--GEAQPPEQPSSMDHTP 533
Cdd:PRK07003 456 RASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASreDAPAAAAPPAPEARPP 535
|
....*...
gi 2024412791 534 DPAACGPS 541
Cdd:PRK07003 536 TPAAAAPA 543
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
382-533 |
1.08e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 45.35 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 382 ANAAANGQNGLLGEHPSDRGTAQPPSHQGTAARTPDVPGSQAHEAADSHPHPPQSEGQP-TEDVAQRQSPKPSEMQAFPA 460
Cdd:PHA03169 129 ESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPdSPGPPQSETPTSSPPPQSPP 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 461 SLEDAVGS----GEPTLNAGHGVEHDDHREPHHK--PPSPTPSLCS-SVGSFHPASNAP---------VDAPAGEAQPPE 524
Cdd:PHA03169 209 DEPGEPQSptpqQAPSPNTQQAVEHEDEPTEPERegPPFPGHRSHSyTVVGWKPSTRPGgvpklclrcTSHPSHRSRLPE 288
|
....*....
gi 2024412791 525 QPSSMDHTP 533
Cdd:PHA03169 289 GQQSEDKVP 297
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
359-560 |
3.75e-04 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 44.05 E-value: 3.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 359 AKPDEFPRKPLglELSLNPLATKANAAANGQNGLLGEHPSDR-GTAQPPSHQGTAARTPD--------VPGSQAHEAADS 429
Cdd:PRK14086 52 AVPNEFAKEVL--EGRLAPIISETLSRELGRPIRIAITVDPSaGEPAPPPPHARRTSEPElprpgrrpYEGYGGPRADDR 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 430 HPHPPQSEGQPTEDVAQRQSPKPSEMQAFPASLEDAvgsGEPTLNAGHgVEHDDHREPHHKPPSPTPSLCSSVG--SFHP 507
Cdd:PRK14086 130 PPGLPRQDQLPTARPAYPAYQQRPEPGAWPRAADDY---GWQQQRLGF-PPRAPYASPASYAPEQERDREPYDAgrPEYD 205
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2024412791 508 ASNAPVDAPAGEAQPPEQPSSMDHTPDPAACGPSEDQQASSLPGEEATALHRD 560
Cdd:PRK14086 206 QRRRDYDHPRPDWDRPRRDRTDRPEPPPGAGHVHRGGPGPPERDDAPVVPIRP 258
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
355-551 |
3.86e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.99 E-value: 3.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 355 LPPPAKPDEFPRKPLGLELSLNPLATKANAAANGQNGLlgEHPsdrGTAQP--PSHQGTAARTPDVPGSQAHEAADSHPH 432
Cdd:pfam03154 252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHM--QHP---VPPQPfpLTPQSSQSQVPPGPSPAAPGQSQQRIH 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 433 PPQSEGQPTEDVAQRQSPKPSEMQAFPaSLEDAVGSGEPTLNAGHGVEHDDH-------REPHHKPPSPTPSLCSSVGSF 505
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPAPLSMP-HIKPPPTTPIPQLPNPQSHKHPPHlsgpspfQMNSNLPPPPALKPLSSLSTH 405
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2024412791 506 HPASNAPVD---APAGE--AQPPEQPSSMDHTPDPAACGPSEDQQASSLPG 551
Cdd:pfam03154 406 HPPSAHPPPlqlMPQSQqlPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQV 456
|
|
| PHA03269 |
PHA03269 |
envelope glycoprotein C; Provisional |
405-537 |
6.65e-04 |
|
envelope glycoprotein C; Provisional
Pssm-ID: 165527 [Multi-domain] Cd Length: 566 Bit Score: 43.18 E-value: 6.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 405 PPSHQGTAARTPDvPGSQAHEAADSHPHP---PQSEGQPTEDVAQRQSPKPSEmQAFPASLEDAVGSGEPtlnaghgveh 481
Cdd:PHA03269 29 PELHTSAATQKPD-PAPAPHQAASRAPDPavaPTSAASRKPDLAQAPTPAASE-KFDPAPAPHQAASRAP---------- 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2024412791 482 DDHREPH-HKPPSPTPSLC-SSVGSFHPAsnaPVDAPAgeaqppeqpSSMDHTPDPAA 537
Cdd:PHA03269 97 DPAVAPQlAAAPKPDAAEAfTSAAQAHEA---PADAGT---------SAASKKPDPAA 142
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
378-554 |
7.07e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.05 E-value: 7.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 378 LATKANAAANGQNGLLGEHPSDRGTAQPPSHQGTAARTPDVPGSQAHEAADSHPHPPQSEGQPTEDVAQRQSPKPSE-MQ 456
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDgGD 667
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 457 AFPASLEDAVGSGE---PTLNAGHGVEHDDHREPHHKPPSPTPSLcssvgsfHPASNAPVDAPAGEAQPPEQPSSMDHTP 533
Cdd:PRK07764 668 GWPAKAGGAAPAAPppaPAPAAPAAPAGAAPAQPAPAPAATPPAG-------QADDPAAQPPQAAQGASAPSPAADDPVP 740
|
170 180
....*....|....*....|.
gi 2024412791 534 DPAAcgPSEDQQASSLPGEEA 554
Cdd:PRK07764 741 LPPE--PDDPPDPAGAPAQPP 759
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
357-691 |
7.87e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 7.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 357 PPAKPDEFPRKPLGLELSLNPLATKANAAANGQNGllGEHPSDRGTAQPPShqgtaartPDVPGSQAHEAADSHPHPPQS 436
Cdd:PHA03307 71 PPPGPGTEAPANESRSTPTWSLSTLAPASPAREGS--PTPPGPSSPDPPPP--------TPPPASPPPSPAPDLSEMLRP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 437 EGQPTEDVAQRQSPKPSemqAFPASLEDAVGSGEPTLNAGHGVEHDdhrephHKPPSPTPSLCSSVGSFHPASNAPVdap 516
Cdd:PHA03307 141 VGSPGPPPAASPPAAGA---SPAAVASDAASSRQAALPLSSPEETA------RAPSSPPAEPPPSTPPAAASPRPPR--- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 517 ageAQPPEQPSSMDHTPDPAacgpseDQQASSLPGEEATALHRDIPE-DIGETQHGVLLLNGMDSKASLPKSASAGELGg 595
Cdd:PHA03307 209 ---RSSPISASASSPAPAPG------RSAADDAGASSSDSSSSESSGcGWGPENECPLPRPAPITLPTRIWEASGWNGP- 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 596 lqqstemaleqgftalGSLAPCRPSGSSTPILSESVALARGNSLHTVVKTTTRLHVAQVTEQDL-ANRRQVALPWPEAAH 674
Cdd:PHA03307 279 ----------------SSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSsSTSSSSESSRGAAVS 342
|
330
....*....|....*..
gi 2024412791 675 PLAATSLLPPATSDTGA 691
Cdd:PHA03307 343 PGPSPSRSPSPSRPPPP 359
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
397-556 |
1.52e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 397 PSDRGTAQPPSHQGTAARTPDVPGSQAHEAADSHPHPPQSEGQPTEDVAQRQSPKPSEMQAfPASLEDAVGSGEPTLNAG 476
Cdd:PRK07764 617 APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA-PAAPPPAPAPAAPAAPAG 695
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 477 HGVEHDDHRePHHKPPSPTPSLCSSVGSFHPASNAPVDAPAGEAQPPeqPSSMDHTPDPAACGPSEDQQASSLPGEEATA 556
Cdd:PRK07764 696 AAPAQPAPA-PAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL--PPEPDDPPDPAGAPAQPPPPPAPAPAAAPAA 772
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
356-567 |
1.84e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 356 PPPAKPDEFPRKPLGLELSLNPLATKANAAANGQngllgEHPSDRGTAQPPSHQGTAARTPDVP--GSQAHEAADSHPHP 433
Cdd:PRK07764 591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAP-----AAPAPAGAAAAPAEASAAPAPGVAApeHHPKHVAVPDASDG 665
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 434 PQSEGQPTEDVAQRQSPKPSEMQAFPASLEDAVGSGEPTLNAGHGVEHDDHREPHHKPPSPTPSLCSSVGSFH------- 506
Cdd:PRK07764 666 GDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPvplppep 745
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024412791 507 PASNAPVDAPAGEAQPPEQPSSMDHTPDPAACGPSEDQQASSLPGEEATALHRDIPEDIGE 567
Cdd:PRK07764 746 DDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAM 806
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
392-667 |
2.50e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.40 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 392 LLGEHPSDRGTAQPPSHQGTAARTPDVPGSQAHEAADSHPHPPQSEGQPTEDVA---QRQSPKPSEMQAFPASLEDAVGS 468
Cdd:PRK12323 360 MLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAaaaRAVAAAPARRSPAPEALAAARQA 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 469 GEptlnaghgvehddHREPHHKPPSPTPSlCSSVGSFHPASNAPVDAPAGEAQPPEQPS-SMDHTPDPAACGPSEDqqas 547
Cdd:PRK12323 440 SA-------------RGPGGAPAPAPAPA-AAPAAAARPAAAGPRPVAAAAAAAPARAApAAAPAPADDDPPPWEE---- 501
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 548 sLPGEEATalhrDIPEDIGETQHGVLLLNGMDSKASLPKSASAGELGGLQQSTEMALEQGFTALGSLAPCRPSGSSTPIL 627
Cdd:PRK12323 502 -LPPEFAS----PAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDM 576
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2024412791 628 SE---------------SVALARGNSLHTVVKTTTRLHV--AQVTEQDLANRRQVAL 667
Cdd:PRK12323 577 FDgdwpalaarlpvrglAQQLARQSELAGVEGDTVRLRVpvPALAEAEVVERLQAAL 633
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
356-554 |
5.20e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.35 E-value: 5.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 356 PPPAKPDEFPRKPLGLELSLNPLATKANAAANGQNGLLGEHPSDRGTAQPPSHQGTAARTPDVPGSQAHEA-ADSHPHPP 434
Cdd:PRK07764 627 PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAApAQPAPAPA 706
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 435 QSEGQPTEDVAQRQSPKPSEMQAFPASLEDAVGSGEPtlnaghgvEHDDHREPHHKPPSPTPslcssvgsfhPASNAPVD 514
Cdd:PRK07764 707 ATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP--------EPDDPPDPAGAPAQPPP----------PPAPAPAA 768
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2024412791 515 APAGEAQPPEQPSSMDHTPDPAACGPSEDQQASSLPGEEA 554
Cdd:PRK07764 769 APAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMEL 808
|
|
| AF-4 |
pfam05110 |
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ... |
355-586 |
5.84e-03 |
|
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Pssm-ID: 461550 [Multi-domain] Cd Length: 514 Bit Score: 39.72 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 355 LPPPAKPDE--FPRKPLGLELSL---NPLATKANAAANGQNGLLGEHPSDRGTAQPPSHQGTAaRTPDVPGSQAHEAADS 429
Cdd:pfam05110 82 QTPQEKPDQpfFPDKTSGLPPSFhtsSHSQPMGPPSSSSPSVSSSQSQKKSQARTEPAHGGHS-SSGSQSSQRSQGQSRS 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 430 HP--------HPPQSEGQPTEDVAQRQSPKPSEMQAFPASLEDAVGSgeptLNAGHGVEHDDHR-----EPHHKPPSPTP 496
Cdd:pfam05110 161 KGgqeshsssHHKRQERREDLFSCASLSHSLEELSPLLSSLSSPVKP----LSPSHSRQHTGSKaqnssDHHGKEYSHSK 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 497 SLCSSVGSFHPASNAPVDAPAGEAQPPEQ---------PSSMDHTPdPAACGPSEDQ-QASSlpgeEATALhRDIPEDIG 566
Cdd:pfam05110 237 SPRDSEAGSHGPESPSTSLLASSSQLSSQtfppslpskTSAMQQKP-TAYVRPMDGQdQAPS----ESPEL-KPSPEDYH 310
|
250 260
....*....|....*....|
gi 2024412791 567 ETQHGVLLLNGMDSKASLPK 586
Cdd:pfam05110 311 GQSYGKLSDLKANAKAKLSK 330
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
356-539 |
6.13e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 39.86 E-value: 6.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 356 PPPAKPDEFPRKPLGLELSLNPLATKANAAANGQNGLLGEHPSDRGTAQPPSHQGTAARTPDVPGSQAHEAADSHP-HPP 434
Cdd:PRK12323 385 PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAaARP 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024412791 435 QSEGQPTEDVAQRQSPKPSEMQAFPASLEDAVGSGE---PTLNAGHGVEHDDHREPHHKPPSPTPSLCSSVGSFHPASNA 511
Cdd:PRK12323 465 AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEelpPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPA 544
|
170 180
....*....|....*....|....*...
gi 2024412791 512 PVDAPAGEAQPPEQPSSMDHTPDPAACG 539
Cdd:PRK12323 545 PAAAPAPRAAAATEPVVAPRPPRASASG 572
|
|
|