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Concise Results
Standard Results
Full Results
insulin-degrading enzyme isoform X4 [Gallus gallus]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
9-965
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 918.48
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 9 ITNE IIKSP E D K R E YR GLE L A NG I K A LL I SDP TT DKS S AAL D V HI GS LS DP PNIA GL S HF C EHMLFLGTKKYP KEN EY SQ 88
Cdd:COG1025 31 LAET IIKSP N D P R Q YR AIT L D NG L K V LL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L EHMLFLGTKKYP EPG EY QE 110
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 89 F L S E H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ESCK DRE V NAV DS E HEKNLMN D AW R LF Q LE K A T G 168
Cdd:COG1025 111 F I S K H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E YTLKRSD D GR R IY Q VH K E T L 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 169 NP N HPFS K F GT GN KL TL ETR P tke G IDV R Q ELL K F HST YYS S NLM AICVLGRE SLDEL TS L VVKL F SEVE N K N VP VP EFP 248
Cdd:COG1025 191 NP A HPFS R F SV GN LE TL SDK P --- G SKL R D ELL A F YQR YYS A NLM KLVLYSNQ SLDEL EK L ARQT F GAIP N R N LS VP PIT 267
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 249 EHPFQE E H L RQLYKV VP I K DI R N L YVT FPIP DL Q K YY K S N P GH Y LGH L I G H EG P GSLL SE LK AK G WVYT L VG G QKEGA R G 328
Cdd:COG1025 268 VPLYTP E Q L GIIIHI VP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW LK KQ G LAES L SA G GGISG R N 347
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 329 F MF F I I N V D LT EE GL L H VED II LHM F Q YI QKL R IE G P QEW V F Q E CKD L NAV AFRF KD K E RP RG Y T S K L GGMLHY YP I E E V 408
Cdd:COG1025 348 F GD F S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP MD Y V S W L SDNMLR YP V E D V 427
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 409 L A A E YL LEE F R P DL I EMV L DK L R PEN I R VAIV S K sf EGK TD R T ED WY G T Q Y KQEA I SD E VIK KWQ N A DL N GKFK LP MK N E 488
Cdd:COG1025 428 L D A D YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQ E QLA KWQ Q A SQ N PALS LP EL N P 505
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 489 F IP TN F EILP L E K DATQ y P A L VK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHCNMAY L YLE LL K D S LNE YA Y 568
Cdd:COG1025 506 Y IP DD F SLIK L D K ESAK - P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQVLTR L LDY LL N D A LNE LS Y 584
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 569 A A EL AGL N Y D L QNTIY G MY LS VK G YND KQ HI LL KKIIEKM A T FE ID E K RF EII K EAYM R S L N N FRAEQ P HQHAMYY L RL L 648
Cdd:COG1025 585 Q A SV AGL S Y S L YAHQG G LT LS AS G FTQ KQ PK LL EALLDQL A S FE PT E E RF AQA K SQLL R Q L D N AEKAK P YSQLFSP L SR L 664
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 649 MTEVAWTKD EL KE AL DDV TL PR L K AF IS QLL SR LH I E A L LH GN ITKQA A LGIMQMVEDT L IEHAHTKPLLP sqlvry RE V 728
Cdd:COG1025 665 LQPPYFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L APNGTGEEPRR ------ QV V 738
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 729 Q L PDR G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLGY I V FS G PRRANGIQ GL R F I 808
Cdd:COG1025 739 D L DKS G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLGY V V GA G YMPLGRQP GL G F Y 817
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 809 I QS - EKP P H YL ES R VEA FLK TM E KCIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W GE I ISQQYN FD - R DNI e V A Y 886
Cdd:COG1025 818 V QS p VAS P A YL LE R IDD FLK QF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W VD I GNGDFE FD t R EKL - I A A 896
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024418221 887 L K T LT KD D I I Q F YKV ll AV D AP RRHKVSVH vlaremdscp VV G EFPCQN D V nlapapp L PQPSV I ENMTE F KRS LP LFP 965
Cdd:COG1025 897 V K K LT RA D L I D F FQQ -- AV I AP QGLRLLSQ ---------- SQ G TKHSKA D E ------- L KGWKT I TDISA F QKT LP VKE 956
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
9-965
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 918.48
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 9 ITNE IIKSP E D K R E YR GLE L A NG I K A LL I SDP TT DKS S AAL D V HI GS LS DP PNIA GL S HF C EHMLFLGTKKYP KEN EY SQ 88
Cdd:COG1025 31 LAET IIKSP N D P R Q YR AIT L D NG L K V LL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L EHMLFLGTKKYP EPG EY QE 110
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 89 F L S E H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ESCK DRE V NAV DS E HEKNLMN D AW R LF Q LE K A T G 168
Cdd:COG1025 111 F I S K H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E YTLKRSD D GR R IY Q VH K E T L 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 169 NP N HPFS K F GT GN KL TL ETR P tke G IDV R Q ELL K F HST YYS S NLM AICVLGRE SLDEL TS L VVKL F SEVE N K N VP VP EFP 248
Cdd:COG1025 191 NP A HPFS R F SV GN LE TL SDK P --- G SKL R D ELL A F YQR YYS A NLM KLVLYSNQ SLDEL EK L ARQT F GAIP N R N LS VP PIT 267
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 249 EHPFQE E H L RQLYKV VP I K DI R N L YVT FPIP DL Q K YY K S N P GH Y LGH L I G H EG P GSLL SE LK AK G WVYT L VG G QKEGA R G 328
Cdd:COG1025 268 VPLYTP E Q L GIIIHI VP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW LK KQ G LAES L SA G GGISG R N 347
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 329 F MF F I I N V D LT EE GL L H VED II LHM F Q YI QKL R IE G P QEW V F Q E CKD L NAV AFRF KD K E RP RG Y T S K L GGMLHY YP I E E V 408
Cdd:COG1025 348 F GD F S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP MD Y V S W L SDNMLR YP V E D V 427
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 409 L A A E YL LEE F R P DL I EMV L DK L R PEN I R VAIV S K sf EGK TD R T ED WY G T Q Y KQEA I SD E VIK KWQ N A DL N GKFK LP MK N E 488
Cdd:COG1025 428 L D A D YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQ E QLA KWQ Q A SQ N PALS LP EL N P 505
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 489 F IP TN F EILP L E K DATQ y P A L VK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHCNMAY L YLE LL K D S LNE YA Y 568
Cdd:COG1025 506 Y IP DD F SLIK L D K ESAK - P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQVLTR L LDY LL N D A LNE LS Y 584
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 569 A A EL AGL N Y D L QNTIY G MY LS VK G YND KQ HI LL KKIIEKM A T FE ID E K RF EII K EAYM R S L N N FRAEQ P HQHAMYY L RL L 648
Cdd:COG1025 585 Q A SV AGL S Y S L YAHQG G LT LS AS G FTQ KQ PK LL EALLDQL A S FE PT E E RF AQA K SQLL R Q L D N AEKAK P YSQLFSP L SR L 664
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 649 MTEVAWTKD EL KE AL DDV TL PR L K AF IS QLL SR LH I E A L LH GN ITKQA A LGIMQMVEDT L IEHAHTKPLLP sqlvry RE V 728
Cdd:COG1025 665 LQPPYFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L APNGTGEEPRR ------ QV V 738
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 729 Q L PDR G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLGY I V FS G PRRANGIQ GL R F I 808
Cdd:COG1025 739 D L DKS G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLGY V V GA G YMPLGRQP GL G F Y 817
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 809 I QS - EKP P H YL ES R VEA FLK TM E KCIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W GE I ISQQYN FD - R DNI e V A Y 886
Cdd:COG1025 818 V QS p VAS P A YL LE R IDD FLK QF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W VD I GNGDFE FD t R EKL - I A A 896
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024418221 887 L K T LT KD D I I Q F YKV ll AV D AP RRHKVSVH vlaremdscp VV G EFPCQN D V nlapapp L PQPSV I ENMTE F KRS LP LFP 965
Cdd:COG1025 897 V K K LT RA D L I D F FQQ -- AV I AP QGLRLLSQ ---------- SQ G TKHSKA D E ------- L KGWKT I TDISA F QKT LP VKE 956
PRK15101
PRK15101 protease3; Provisional
13-900
2.58e-148
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 464.84
E-value: 2.58e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 13 I I KS PE D K R E Y RGLE L A NG IKA LL I SDP TTD KS S AAL DVHI GSL S DP PNIA GL S H FC EHM LFL G T KKYP KENEYSQ FL SE 92
Cdd:PRK15101 34 I R KS EK D P R Q Y QAIR L D NG MTV LL V SDP QAV KS L AAL ALPV GSL E DP DAQQ GL A H YL EHM VLM G S KKYP QPDSLAE FL KK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 93 H A GS S NA F T SGEH T NY Y FD V SHEH L EG A L DR F A QFFLC PL F D ESCK DRE V NAV DS E HEKNLMN D AW R LF Q LEKA T G NP N H 172
Cdd:PRK15101 114 H G GS H NA S T ASYR T AF Y LE V ENDA L PP A V DR L A DAIAE PL L D PKNA DRE R NAV NA E LTMARSR D GM R MA Q VSAE T I NP A H 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 173 P F S K F GT GN klt LET RPT K E G IDVRQE L LK F HST YYS S NLM AICVLGRES L D EL TS L VVKL F SE V E NKN VP VPE FPEHPF 252
Cdd:PRK15101 194 P G S R F SG GN --- LET LSD K P G SKLQDA L VD F YQR YYS A NLM KAVIYSNQP L P EL AK L AADT F GR V P NKN AS VPE ITVPVV 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 253 QEEHLRQLYKV VP IKDIRN L Y V T F P I PDLQKYYK S NPGH Y LGH LIG HEG PG S L LSE L KAK G wvyt L VG G QKE GA ----- R 327
Cdd:PRK15101 271 TDAQKGIIIHY VP AQPRKV L R V E F R I DNNSAKFR S KTDE Y ISY LIG NRS PG T L SDW L QKQ G ---- L AE G ISA GA dpmvd R 346
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 328 GFMF F I I N V D LT EE GL LHVEDIILHM F Q Y IQK LR IE G PQEWV F Q E CKDLNAVA FR FKDKE R PRG Y TSK L GGMLHYY P I E E 407
Cdd:PRK15101 347 NSGV F A I S V S LT DK GL AQRDQVVAAI F S Y LNL LR EK G IDKSY F D E LAHVLDLD FR YPSIT R DMD Y IEW L ADTMLRV P V E H 426
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 408 V L A A E Y LLEEFR P DL I EMV L DKLR P E N I R VAIV S K sf EGKTDR T EDWYGTQ Y KQEA IS DEVIKK WQ NADL N GKFK LP MK N 487
Cdd:PRK15101 427 T L D A P Y IADRYD P KA I KAR L AEMT P Q N A R IWYI S P -- QEPHNK T AYFVDAP Y QVDK IS EQTFAD WQ QKAQ N IALS LP EL N 504
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 488 EF IP TN F EILPLE K d A TQY P A L VK D T ------ A M SKLW F KQD dkffl PKA CLNFEFFS P F A YVDPLHCNMAY L -- YL EL L 559
Cdd:PRK15101 505 PY IP DD F SLIKAD K - A YKH P E L IV D E pglrvv Y M PSQY F ADE ----- PKA DISLVLRN P K A MDSARNQVLFA L nd YL AG L 578
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 560 kd S L NEYAYA A ELA G LNYDL q N TIY G MYLSVK GY N dk Q HI -- LL KKII E KMAT F EID E KRFEII K EA Y MRS L NNFRAEQP 637
Cdd:PRK15101 579 -- A L DQLSNQ A SVG G ISFST - N ANN G LMVNAN GY T -- Q RL pq LL QALL E GYFS F TPT E EQLAQA K SW Y REQ L DSAEKGKA 653
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 638 HQH A MYYLRL L MTEVAWTK DE LKEA L DDV TL PRLK A FISQ LLS RLHI E A L LH GN I T KQAA lgimqmve D TL IEHAHTK - P 716
Cdd:PRK15101 654 YEQ A IMPAQM L SQVPYFER DE RRKL L PSI TL KDVL A YRDA LLS GATP E F L VV GN L T EEQV -------- T TL ARDVQKQ l G 725
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 717 LLPSQLV R YRE V QLPDRGWFVYQQRNEVHNNCGIEI Y YQ T --- DM QS TSENMF L E lfc QII SEPCF N T LRT K EQLGY I VF 793
Cdd:PRK15101 726 ADGTEWW R GKD V VVDKKQSVNFEKAGSSTDSALAAV Y VP T gyd EY QS SAYSSL L G --- QII QPWFY N Q LRT E EQLGY A VF 802
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 794 SG P RRANGIQ G LR F II QS - E K P P H YL ES R VE AF LKTM E KCIED M TE E A F QKHI QAL AIRR L DK P KK L SA E CAKYWGEIIS 872
Cdd:PRK15101 803 AF P MSVGRQW G MG F LL QS n D K Q P A YL WQ R YQ AF FPQA E AKLRA M KP E E F AQYQ QAL INQL L QA P QT L GE E ASRLSKDFDR 882
890 900
....*....|....*....|....*....
gi 2024418221 873 QQYN FD - RD N I e V A YL K T LT KDDIIQ F YK 900
Cdd:PRK15101 883 GNMR FD s RD K I - I A QI K L LT PQKLAD F FH 910
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
381-662
1.22e-130
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 395.40
E-value: 1.22e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 381 FRF KD K ER P RG Y T S K L GGMLHY YP I E EV L AAE YLL E E FR P D LI EMV LD K L R PEN I R VAI VSK S FEG K TD RT E D WYGT Q Y K 460
Cdd:pfam16187 1 FRF QE K SP P SD Y V S S L ASNMQP YP P E DI L SGD YLL R E YD P E LI QEL LD Y L T PEN A R ITL VSK E FEG E TD QK E P WYGT E Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 461 Q E A I SD E VI KKW Q N - ADL N GKFK LP MK N E FIPT N F EILPL E - K DATQ YP A L VK DT AM S K LW F K Q DD K F FL PKA CLNFEFF 538
Cdd:pfam16187 81 V E P I PE E LL KKW K N a PEP N PELH LP EP N P FIPT D F DLKKK E v K EPAK YP V L IR DT PL S R LW Y K K DD T F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 539 SP F AY VD P LHCNMAY LY L ELLKDSLNEYAY A AELAGL N Y D L QN T IY G MY LSV K GYNDK QHI LL K KI I EK MAT FEID EK RF 618
Cdd:pfam16187 161 SP L AY SS P RNAVLTR LY V ELLKDSLNEYAY D AELAGL S Y S L SA T ER G LT LSV S GYNDK LPV LL E KI L EK LRD FEID PD RF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2024418221 619 EIIKE AYM RS LN NF RA EQP H Q H A MY YL RL L MT E VA WT KD E LK EA 662
Cdd:pfam16187 241 EIIKE QLL RS YK NF AL EQP Y Q Q A FD YL LY L LE E RS WT PE E KL EA 284
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
9-965
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 918.48
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 9 ITNE IIKSP E D K R E YR GLE L A NG I K A LL I SDP TT DKS S AAL D V HI GS LS DP PNIA GL S HF C EHMLFLGTKKYP KEN EY SQ 88
Cdd:COG1025 31 LAET IIKSP N D P R Q YR AIT L D NG L K V LL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L EHMLFLGTKKYP EPG EY QE 110
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 89 F L S E H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ESCK DRE V NAV DS E HEKNLMN D AW R LF Q LE K A T G 168
Cdd:COG1025 111 F I S K H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E YTLKRSD D GR R IY Q VH K E T L 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 169 NP N HPFS K F GT GN KL TL ETR P tke G IDV R Q ELL K F HST YYS S NLM AICVLGRE SLDEL TS L VVKL F SEVE N K N VP VP EFP 248
Cdd:COG1025 191 NP A HPFS R F SV GN LE TL SDK P --- G SKL R D ELL A F YQR YYS A NLM KLVLYSNQ SLDEL EK L ARQT F GAIP N R N LS VP PIT 267
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 249 EHPFQE E H L RQLYKV VP I K DI R N L YVT FPIP DL Q K YY K S N P GH Y LGH L I G H EG P GSLL SE LK AK G WVYT L VG G QKEGA R G 328
Cdd:COG1025 268 VPLYTP E Q L GIIIHI VP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW LK KQ G LAES L SA G GGISG R N 347
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 329 F MF F I I N V D LT EE GL L H VED II LHM F Q YI QKL R IE G P QEW V F Q E CKD L NAV AFRF KD K E RP RG Y T S K L GGMLHY YP I E E V 408
Cdd:COG1025 348 F GD F S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP MD Y V S W L SDNMLR YP V E D V 427
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 409 L A A E YL LEE F R P DL I EMV L DK L R PEN I R VAIV S K sf EGK TD R T ED WY G T Q Y KQEA I SD E VIK KWQ N A DL N GKFK LP MK N E 488
Cdd:COG1025 428 L D A D YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQ E QLA KWQ Q A SQ N PALS LP EL N P 505
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 489 F IP TN F EILP L E K DATQ y P A L VK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHCNMAY L YLE LL K D S LNE YA Y 568
Cdd:COG1025 506 Y IP DD F SLIK L D K ESAK - P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQVLTR L LDY LL N D A LNE LS Y 584
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 569 A A EL AGL N Y D L QNTIY G MY LS VK G YND KQ HI LL KKIIEKM A T FE ID E K RF EII K EAYM R S L N N FRAEQ P HQHAMYY L RL L 648
Cdd:COG1025 585 Q A SV AGL S Y S L YAHQG G LT LS AS G FTQ KQ PK LL EALLDQL A S FE PT E E RF AQA K SQLL R Q L D N AEKAK P YSQLFSP L SR L 664
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 649 MTEVAWTKD EL KE AL DDV TL PR L K AF IS QLL SR LH I E A L LH GN ITKQA A LGIMQMVEDT L IEHAHTKPLLP sqlvry RE V 728
Cdd:COG1025 665 LQPPYFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L APNGTGEEPRR ------ QV V 738
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 729 Q L PDR G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLGY I V FS G PRRANGIQ GL R F I 808
Cdd:COG1025 739 D L DKS G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLGY V V GA G YMPLGRQP GL G F Y 817
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 809 I QS - EKP P H YL ES R VEA FLK TM E KCIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W GE I ISQQYN FD - R DNI e V A Y 886
Cdd:COG1025 818 V QS p VAS P A YL LE R IDD FLK QF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W VD I GNGDFE FD t R EKL - I A A 896
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024418221 887 L K T LT KD D I I Q F YKV ll AV D AP RRHKVSVH vlaremdscp VV G EFPCQN D V nlapapp L PQPSV I ENMTE F KRS LP LFP 965
Cdd:COG1025 897 V K K LT RA D L I D F FQQ -- AV I AP QGLRLLSQ ---------- SQ G TKHSKA D E ------- L KGWKT I TDISA F QKT LP VKE 956
PRK15101
PRK15101 protease3; Provisional
13-900
2.58e-148
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 464.84
E-value: 2.58e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 13 I I KS PE D K R E Y RGLE L A NG IKA LL I SDP TTD KS S AAL DVHI GSL S DP PNIA GL S H FC EHM LFL G T KKYP KENEYSQ FL SE 92
Cdd:PRK15101 34 I R KS EK D P R Q Y QAIR L D NG MTV LL V SDP QAV KS L AAL ALPV GSL E DP DAQQ GL A H YL EHM VLM G S KKYP QPDSLAE FL KK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 93 H A GS S NA F T SGEH T NY Y FD V SHEH L EG A L DR F A QFFLC PL F D ESCK DRE V NAV DS E HEKNLMN D AW R LF Q LEKA T G NP N H 172
Cdd:PRK15101 114 H G GS H NA S T ASYR T AF Y LE V ENDA L PP A V DR L A DAIAE PL L D PKNA DRE R NAV NA E LTMARSR D GM R MA Q VSAE T I NP A H 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 173 P F S K F GT GN klt LET RPT K E G IDVRQE L LK F HST YYS S NLM AICVLGRES L D EL TS L VVKL F SE V E NKN VP VPE FPEHPF 252
Cdd:PRK15101 194 P G S R F SG GN --- LET LSD K P G SKLQDA L VD F YQR YYS A NLM KAVIYSNQP L P EL AK L AADT F GR V P NKN AS VPE ITVPVV 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 253 QEEHLRQLYKV VP IKDIRN L Y V T F P I PDLQKYYK S NPGH Y LGH LIG HEG PG S L LSE L KAK G wvyt L VG G QKE GA ----- R 327
Cdd:PRK15101 271 TDAQKGIIIHY VP AQPRKV L R V E F R I DNNSAKFR S KTDE Y ISY LIG NRS PG T L SDW L QKQ G ---- L AE G ISA GA dpmvd R 346
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 328 GFMF F I I N V D LT EE GL LHVEDIILHM F Q Y IQK LR IE G PQEWV F Q E CKDLNAVA FR FKDKE R PRG Y TSK L GGMLHYY P I E E 407
Cdd:PRK15101 347 NSGV F A I S V S LT DK GL AQRDQVVAAI F S Y LNL LR EK G IDKSY F D E LAHVLDLD FR YPSIT R DMD Y IEW L ADTMLRV P V E H 426
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 408 V L A A E Y LLEEFR P DL I EMV L DKLR P E N I R VAIV S K sf EGKTDR T EDWYGTQ Y KQEA IS DEVIKK WQ NADL N GKFK LP MK N 487
Cdd:PRK15101 427 T L D A P Y IADRYD P KA I KAR L AEMT P Q N A R IWYI S P -- QEPHNK T AYFVDAP Y QVDK IS EQTFAD WQ QKAQ N IALS LP EL N 504
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 488 EF IP TN F EILPLE K d A TQY P A L VK D T ------ A M SKLW F KQD dkffl PKA CLNFEFFS P F A YVDPLHCNMAY L -- YL EL L 559
Cdd:PRK15101 505 PY IP DD F SLIKAD K - A YKH P E L IV D E pglrvv Y M PSQY F ADE ----- PKA DISLVLRN P K A MDSARNQVLFA L nd YL AG L 578
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 560 kd S L NEYAYA A ELA G LNYDL q N TIY G MYLSVK GY N dk Q HI -- LL KKII E KMAT F EID E KRFEII K EA Y MRS L NNFRAEQP 637
Cdd:PRK15101 579 -- A L DQLSNQ A SVG G ISFST - N ANN G LMVNAN GY T -- Q RL pq LL QALL E GYFS F TPT E EQLAQA K SW Y REQ L DSAEKGKA 653
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 638 HQH A MYYLRL L MTEVAWTK DE LKEA L DDV TL PRLK A FISQ LLS RLHI E A L LH GN I T KQAA lgimqmve D TL IEHAHTK - P 716
Cdd:PRK15101 654 YEQ A IMPAQM L SQVPYFER DE RRKL L PSI TL KDVL A YRDA LLS GATP E F L VV GN L T EEQV -------- T TL ARDVQKQ l G 725
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 717 LLPSQLV R YRE V QLPDRGWFVYQQRNEVHNNCGIEI Y YQ T --- DM QS TSENMF L E lfc QII SEPCF N T LRT K EQLGY I VF 793
Cdd:PRK15101 726 ADGTEWW R GKD V VVDKKQSVNFEKAGSSTDSALAAV Y VP T gyd EY QS SAYSSL L G --- QII QPWFY N Q LRT E EQLGY A VF 802
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 794 SG P RRANGIQ G LR F II QS - E K P P H YL ES R VE AF LKTM E KCIED M TE E A F QKHI QAL AIRR L DK P KK L SA E CAKYWGEIIS 872
Cdd:PRK15101 803 AF P MSVGRQW G MG F LL QS n D K Q P A YL WQ R YQ AF FPQA E AKLRA M KP E E F AQYQ QAL INQL L QA P QT L GE E ASRLSKDFDR 882
890 900
....*....|....*....|....*....
gi 2024418221 873 QQYN FD - RD N I e V A YL K T LT KDDIIQ F YK 900
Cdd:PRK15101 883 GNMR FD s RD K I - I A QI K L LT PQKLAD F FH 910
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
381-662
1.22e-130
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 395.40
E-value: 1.22e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 381 FRF KD K ER P RG Y T S K L GGMLHY YP I E EV L AAE YLL E E FR P D LI EMV LD K L R PEN I R VAI VSK S FEG K TD RT E D WYGT Q Y K 460
Cdd:pfam16187 1 FRF QE K SP P SD Y V S S L ASNMQP YP P E DI L SGD YLL R E YD P E LI QEL LD Y L T PEN A R ITL VSK E FEG E TD QK E P WYGT E Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 461 Q E A I SD E VI KKW Q N - ADL N GKFK LP MK N E FIPT N F EILPL E - K DATQ YP A L VK DT AM S K LW F K Q DD K F FL PKA CLNFEFF 538
Cdd:pfam16187 81 V E P I PE E LL KKW K N a PEP N PELH LP EP N P FIPT D F DLKKK E v K EPAK YP V L IR DT PL S R LW Y K K DD T F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 539 SP F AY VD P LHCNMAY LY L ELLKDSLNEYAY A AELAGL N Y D L QN T IY G MY LSV K GYNDK QHI LL K KI I EK MAT FEID EK RF 618
Cdd:pfam16187 161 SP L AY SS P RNAVLTR LY V ELLKDSLNEYAY D AELAGL S Y S L SA T ER G LT LSV S GYNDK LPV LL E KI L EK LRD FEID PD RF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2024418221 619 EIIKE AYM RS LN NF RA EQP H Q H A MY YL RL L MT E VA WT KD E LK EA 662
Cdd:pfam16187 241 EIIKE QLL RS YK NF AL EQP Y Q Q A FD YL LY L LE E RS WT PE E KL EA 284
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
33-170
8.63e-49
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 169.79
E-value: 8.63e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 33 KALLI SDP TT D K S SAA L DVHI GS LSD P P N IA GL S HF C EHM L F L GTKKYP k E NE YSQF L SEHA GS S NAFTS G E H T N YY FD V 112
Cdd:pfam00675 1 RVASE SDP PA D T S TVG L WIDA GS RYE P D N NN GL A HF L EHM A F K GTKKYP - S NE LEEE L EKLG GS L NAFTS R E N T V YY AE V 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024418221 113 SHEH L EG A L DR F A Q FF LC PLF D ES CKD R ------- EV N AVDSE HEK ---- NL MND A W R LFQ L EKATGN P 170
Cdd:pfam00675 80 LNDD L PK A V DR L A D FF RN PLF T ES EIE R erlvvly EV E AVDSE PQL vvle NL HAA A Y R NTP L GRSLLG P 148
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
9-440
2.55e-47
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 175.11
E-value: 2.55e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 9 ITNEIIKS P EDKREYRGLE L A NG IKAL L IS DP TTDKS S AA L D V HI GS LSD PP NIA GL S HF C EHMLF L GTKK YPK e N E YSQ 88
Cdd:COG0612 1 LAPAAGAA P AAAPDVEEFT L P NG LRVI L VP DP EAPVV S VR L W V RV GS RDE PP GKT GL A HF L EHMLF K GTKK RSA - G E IAE 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 89 F L SEHA GS S NAFTS GEH T N YY FD V SH E H LE G AL DRF A QFF L C P L FDE SCKD RE VNA V DS E HEKNLMNDAWRL F QLEK A TG 168
Cdd:COG0612 80 E L EALG GS L NAFTS FDY T V YY LS V LS E D LE L AL ELL A DRL L N P T FDE EELE RE RGV V LE E IRRYEDDPDGLA F EALL A AL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 169 NPN HP FSKFGT G NKLTL E T rptkeg I D v R QE L LK F HST YY SS N LMAIC V L G RESLD E LTS LV V K L F SEVENKNV P VPEF P 248
Cdd:COG0612 160 YGD HP YGRPII G TEESI E A ------ I T - R ED L RA F YKR YY RP N NAVLV V V G DVDPE E VLA LV E K Y F GDLPAGPA P PRPD P 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 249 EH P F Q EEHL R qly K VV PIK D IR -- NLYVTF P I P DL qkyyk SN P GH Y ---- L GHLI G H e G PG S L L SEL -- KA KG WV Y T l VG 320
Cdd:COG0612 233 AE P P Q TGPR R --- V VV DDP D AE qa HILLGY P G P AR ----- DD P DY Y aldv L NEIL G G - G FS S R L FQE lr EK KG LA Y S - VG 302
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 321 GQKEGA R GFMF F I I NVDLTEEG L LHVEDI IL hmf QYIQK L RI EG PQ E WVFQEC K D -- L NAV A FRF kdk E RPR G YT S K LG G 398
Cdd:COG0612 303 SSFSPY R DAGL F T I YAGTAPDK L EEALAA IL --- EELER L AK EG VT E EELERA K N ql L GSL A LSL --- E SNS G LA S Q LG R 376
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 2024418221 399 MLH Y Y - PIEEVLAAEYLL E EFRPDLIEM V LD K - L R P E N IR V AI V 440
Cdd:COG0612 377 YEL Y G g DLDYLEEYLERI E AVTAEDVQA V AR K y L D P D N LV V VV V 420
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
197-375
1.30e-29
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 116.34
E-value: 1.30e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 197 R QE L LK F HSTY YS SNL M AICVL G RESLD EL TS L VV K L F SEVENK nv P VPEFPEH P FQEEH L RQLYK VVP I KD IRN -- L YV 274
Cdd:pfam05193 4 R ED L RD F YKKH YS PDN M VLVIV G DVDHE EL LD L AE K Y F GDLPAS -- P KGKPRPP P LEPAK L KGREV VVP K KD EPQ ah L AL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 275 T FP I P D L QKYYK S NPGHY L GH L I G HEGPGS L LS EL KA K - G WV Y TLVGGQKEG a RGFMF F I I NVDLTE E gll H V EDI I LHM 353
Cdd:pfam05193 82 A FP G P P L NNDED S LALDV L NE L L G GGMSSR L FQ EL RE K e G LA Y SVSSFNDSY - SDSGL F G I YATVDP E --- N V DEV I ELI 157
170 180
....*....|....*....|..
gi 2024418221 354 FQYIQ KL RI EG PQ E WVFQEC K D 375
Cdd:pfam05193 158 LEELE KL AQ EG VT E EELERA K N 179
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
665-848
1.64e-15
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 75.51
E-value: 1.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 665 DV T LPR L KA F ISQLL S RLHIEALLH G NITKQAA L gim QMV E DTL ieh AHTKPLLPSQLVRYREVQLPDR G WF V YQQRNEV 744
Cdd:pfam05193 1 SL T RED L RD F YKKHY S PDNMVLVIV G DVDHEEL L --- DLA E KYF --- GDLPASPKGKPRPPPLEPAKLK G RE V VVPKKDE 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024418221 745 HNNC g IEIYYQT - DMQSTSENMF L ELFCQIISE ---- PC F NT LR T KE Q L G Y I V F S GPRRAN -- G IQ G LRFIIQS E K pphy 817
Cdd:pfam05193 75 PQAH - LALAFPG p PLNNDEDSLA L DVLNELLGG gmss RL F QE LR E KE G L A Y S V S S FNDSYS ds G LF G IYATVDP E N ---- 149
170 180 190
....*....|....*....|....*....|..
gi 2024418221 818 LESRV E AF L KTM EK - CI E DM TEE AFQKHIQA L 848
Cdd:pfam05193 150 VDEVI E LI L EEL EK l AQ E GV TEE ELERAKNQ L 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
