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Conserved domains on  [gi|2024420754|ref|XP_040559730|]
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ceramide kinase-like protein isoform X1 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CERK_C pfam19280
Ceramide kinase C-terminal domain; This domain is found at the C-terminus of ceramide kinase ...
 311-534 9.36e-147

Ceramide kinase C-terminal domain; This domain is found at the C-terminus of ceramide kinase enzymes. It is related to the beta sandwich domain of NAD kinases. Along with the N-terminal domain it catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This family contains ceramide kinase like proteins that lack the ceramide kinase activity. It also contains ore distantly related proteins this may have different functions.


:

Pssm-ID: 466025  Cd Length: 222  Bit Score: 420.26  E-value: 9.36e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 311 FSAMFGFGARTLALAEKHRWMPSNQRKDFAFIKTLADLKTEKCELSFLPLQISQEDSHENDRKKKRKNKKkgskDQWHKI 390
Cdd:pfam19280   1 FSAMFGFGGRTLALAEKHRWMSPSQRRDFAVIKTLAKLKPEDCELSFLPLNSSQDLQERKAQGSPKSDCE----EQWQTI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 391 QGDFLNVSIMAIPCLCSMAPRGLAPNTRLNNGSMALIVVRNTSRTEFIKHLKRYASVKNQFSFPFVETYTVQEVKVQLRI 470
Cdd:pfam19280  77 QGLFLNVSIMAIPCLCSMAPRGLAPNTRLNNGSMALIVVRNTSRSEFIKHLKRYASVKNQFNFPFVETYTVEEVKVRPRS 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024420754 471 KSGLDAKENTD-LNATAAEENYPWNIDGDLVE-ASEVHVRVHPQLIHLYGVNTDDLESSKATCNCI 534
Cdd:pfam19280 157 QSGWSDEESEKgTPIIASEGTYPWNIDGDLMEvASEVLIRVHPRLITLYGVSVEEMEDSKVTCSCI 222
DAGK_cat super family cl01255
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 51-517 1.21e-45

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


The actual alignment was detected with superfamily member PLN02204:

Pssm-ID: 445337 [Multi-domain]  Cd Length: 601  Bit Score: 169.30  E-value: 1.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754  51 DVVLSARR--LRWSPIVPESPAGDSSTALQVKEEI---IEMKDVFSVKV---------KRRRFVGQKKGGTLLGITIFK- 115
Cdd:PLN02204   32 DVSLTLNSdgLSWKCLDSSDNDGTTCLGIKFCEKSeteIKFSDVYAVEFinyglihspKLSHAKGCFRERLSETQEMYRf 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 116 CLHK-EENKLTDCAIHLNNFSEDH-----CHSWFRRLKEILNGFQNRPKSLKVFVNPSSHKREAARIYyEQVSPLFKLAD 189
Cdd:PLN02204  112 TVHGfQRSRKEPCLWVLAVYTFGHkdlqtCQSWVDRLNASLNKEVGRPKNLLVFVHPLSGKGSGSRTW-ETVSPIFIRAK 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 190 IKTDVTVTEYEGHALSVLKEC---ELQAFDGVVCVGGDGFVSEVVHGLL---LKAQI----------DAGKGTDYIPAP- 252
Cdd:PLN02204  191 VKTKVIVTERAGHAFDVMASIsnkELKSYDGVIAVGGDGFFNEILNGYLlsrLKVPYppspsdsvhsVQSRGSSSVHEPn 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 253 --------------VRAPVP----------------------------LGVIPAGTTNILAYTLYGIKHTVTATLHIVMG 290
Cdd:PLN02204  271 etvhecdnedhsplLSDSVQevmnfrtengscegdqdsdfpfpnerfrFGIIPAGSTDAIVMCTTGERDPVTSALHIILG 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 291 HIQPVDAC--------TFSTPSRLLRFGFS-AMFGFGARTLALAEKHRWMpSNQRKDFAFIKTLADLKTEKCELSFL--P 359
Cdd:PLN02204  351 RRVCLDIAqvvrwkttSTSEIEPYVRYAASfAGYGFYGDVISESEKYRWM-GPKRYDYAGTKVFLKHRSYEAEVAYLetE 429

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 360 LQISQEDSHE-------------------------NDRKKKRKNKKKGSKDQWHKIQGDFLNVSIMAIPCLCSMAPRGLA 414
Cdd:PLN02204  430 SEKSKASSEArkrtgpkksekivcrtncsvcntkvSTNSPSTTPNSCPEETRWLRSKGRFLSVGAAIISNRNERAPDGLV 509

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 415 PNTRLNNGSMALIVVRNTSRTEFIKHLKRYASVKNQ-FSFPFVETYtvqevkvqlriksgldakENTDLNATAAEENYPW 493
Cdd:PLN02204  510 ADAHLSDGFLHLILIKDCPHPLYLWHLTQLAKRGGEpLNFEFVEHH------------------KTPAFTFTSFGDESVW 571

                         570       580
                  ....*....|....*....|....
gi 2024420754 494 NIDGDLVEASEVHVRVHPQLIHLY 517
Cdd:PLN02204  572 NLDGEIFQAHQLSAQVFRGLVNLF 595
 
Name Accession Description Interval E-value
CERK_C pfam19280
Ceramide kinase C-terminal domain; This domain is found at the C-terminus of ceramide kinase ...
 311-534 9.36e-147

Ceramide kinase C-terminal domain; This domain is found at the C-terminus of ceramide kinase enzymes. It is related to the beta sandwich domain of NAD kinases. Along with the N-terminal domain it catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This family contains ceramide kinase like proteins that lack the ceramide kinase activity. It also contains ore distantly related proteins this may have different functions.


Pssm-ID: 466025  Cd Length: 222  Bit Score: 420.26  E-value: 9.36e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 311 FSAMFGFGARTLALAEKHRWMPSNQRKDFAFIKTLADLKTEKCELSFLPLQISQEDSHENDRKKKRKNKKkgskDQWHKI 390
Cdd:pfam19280   1 FSAMFGFGGRTLALAEKHRWMSPSQRRDFAVIKTLAKLKPEDCELSFLPLNSSQDLQERKAQGSPKSDCE----EQWQTI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 391 QGDFLNVSIMAIPCLCSMAPRGLAPNTRLNNGSMALIVVRNTSRTEFIKHLKRYASVKNQFSFPFVETYTVQEVKVQLRI 470
Cdd:pfam19280  77 QGLFLNVSIMAIPCLCSMAPRGLAPNTRLNNGSMALIVVRNTSRSEFIKHLKRYASVKNQFNFPFVETYTVEEVKVRPRS 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024420754 471 KSGLDAKENTD-LNATAAEENYPWNIDGDLVE-ASEVHVRVHPQLIHLYGVNTDDLESSKATCNCI 534
Cdd:pfam19280 157 QSGWSDEESEKgTPIIASEGTYPWNIDGDLMEvASEVLIRVHPRLITLYGVSVEEMEDSKVTCSCI 222
PLN02204 PLN02204
diacylglycerol kinase
 51-517 1.21e-45

diacylglycerol kinase


Pssm-ID: 215126 [Multi-domain]  Cd Length: 601  Bit Score: 169.30  E-value: 1.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754  51 DVVLSARR--LRWSPIVPESPAGDSSTALQVKEEI---IEMKDVFSVKV---------KRRRFVGQKKGGTLLGITIFK- 115
Cdd:PLN02204   32 DVSLTLNSdgLSWKCLDSSDNDGTTCLGIKFCEKSeteIKFSDVYAVEFinyglihspKLSHAKGCFRERLSETQEMYRf 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 116 CLHK-EENKLTDCAIHLNNFSEDH-----CHSWFRRLKEILNGFQNRPKSLKVFVNPSSHKREAARIYyEQVSPLFKLAD 189
Cdd:PLN02204  112 TVHGfQRSRKEPCLWVLAVYTFGHkdlqtCQSWVDRLNASLNKEVGRPKNLLVFVHPLSGKGSGSRTW-ETVSPIFIRAK 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 190 IKTDVTVTEYEGHALSVLKEC---ELQAFDGVVCVGGDGFVSEVVHGLL---LKAQI----------DAGKGTDYIPAP- 252
Cdd:PLN02204  191 VKTKVIVTERAGHAFDVMASIsnkELKSYDGVIAVGGDGFFNEILNGYLlsrLKVPYppspsdsvhsVQSRGSSSVHEPn 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 253 --------------VRAPVP----------------------------LGVIPAGTTNILAYTLYGIKHTVTATLHIVMG 290
Cdd:PLN02204  271 etvhecdnedhsplLSDSVQevmnfrtengscegdqdsdfpfpnerfrFGIIPAGSTDAIVMCTTGERDPVTSALHIILG 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 291 HIQPVDAC--------TFSTPSRLLRFGFS-AMFGFGARTLALAEKHRWMpSNQRKDFAFIKTLADLKTEKCELSFL--P 359
Cdd:PLN02204  351 RRVCLDIAqvvrwkttSTSEIEPYVRYAASfAGYGFYGDVISESEKYRWM-GPKRYDYAGTKVFLKHRSYEAEVAYLetE 429

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 360 LQISQEDSHE-------------------------NDRKKKRKNKKKGSKDQWHKIQGDFLNVSIMAIPCLCSMAPRGLA 414
Cdd:PLN02204  430 SEKSKASSEArkrtgpkksekivcrtncsvcntkvSTNSPSTTPNSCPEETRWLRSKGRFLSVGAAIISNRNERAPDGLV 509

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 415 PNTRLNNGSMALIVVRNTSRTEFIKHLKRYASVKNQ-FSFPFVETYtvqevkvqlriksgldakENTDLNATAAEENYPW 493
Cdd:PLN02204  510 ADAHLSDGFLHLILIKDCPHPLYLWHLTQLAKRGGEpLNFEFVEHH------------------KTPAFTFTSFGDESVW 571

                         570       580
                  ....*....|....*....|....
gi 2024420754 494 NIDGDLVEASEVHVRVHPQLIHLY 517
Cdd:PLN02204  572 NLDGEIFQAHQLSAQVFRGLVNLF 595
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 156-517 2.58e-34

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 131.13  E-value: 2.58e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 156 RPKSLKVFVNPSSHkREAARIYYEQVSPLFKLADIKTDVTVTEYEGHALSVLKECELQAFDGVVCVGGDGFVSEVVHGLl 235
Cdd:COG1597     1 AMMRALLIVNPASG-RGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGL- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 236 lkaqidagkgtdyipapVRAPVPLGVIPAGTTNILAYTLyGIKHTVTATLHIVM-GHIQPVDACTFSTpsrlLRFGFSAM 314
Cdd:COG1597    79 -----------------AGTGPPLGILPLGTGNDFARAL-GIPLDPEAALEALLtGRTRRIDLGRVNG----RYFLNVAG 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 315 FGFGARTLALAEKH-RWMPSNQRKDFAFIKTLADLKTEKCELSFlplqisqeDSHEndrkkkrknkkkgskdqwhkIQGD 393
Cdd:COG1597   137 IGFDAEVVERANRAlKRRLGKLAYVLAALRALLRYRPFRLRIEL--------DGEE--------------------IEGE 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 394 FLNVSImaipCLCSMAPRG--LAPNTRLNNGSMALIVVRNTSRTEFIKHLKRYASvKNQFSFPFVETYTVQEVKVQlrik 471
Cdd:COG1597   189 ALLVAV----GNGPYYGGGlrLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLR-GRHLRHPGVRYFRAREVEIE---- 259

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 2024420754 472 sgldakentdlnataAEENYPWNIDGDLV-EASEVHVRVHPQLIHLY 517
Cdd:COG1597   260 ---------------SDRPLPVQLDGEPLgLATPLEFEVLPGALRVL 291
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 160-299 3.20e-28

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 108.83  E-value: 3.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 160 LKVFVNPSSHKREAARIYyEQVSPLFKLADIKTDVTVTEYEGHALSVLKECELQAFDGVVCVGGDGFVSEVVHGLllkaq 239
Cdd:pfam00781   2 LLVIVNPKSGGGKGKKLL-RKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGL----- 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024420754 240 idagkgtdyipAPVRAPVPLGVIPAGTTNILAYTLyGI-KHTVTATLHIVMGHIQPVDACT 299
Cdd:pfam00781  76 -----------AGLATRPPLGIIPLGTGNDFARAL-GIpGDPEEALEAILKGQTRPVDVGK 124
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 165-516 3.96e-09

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 57.90  E-value: 3.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 165 NPSSHKREAARIYyEQVSPLFKLADIKTDVTVTEYEGHALSVLKECELQAFDGVVCVGGDGFVSEVVHGLllkaqidagK 244
Cdd:TIGR00147   9 NPTAGKSNDNKPL-REVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNAL---------I 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 245 GTDYIPApvrapvpLGVIPAGTTNILAyTLYGIKHTVTATLHIVM-GHIQPVDACTFSTPSRLLRFgfsAMFGFGAR-TL 322
Cdd:TIGR00147  79 QLDDIPA-------LGILPLGTANDFA-RSLGIPEDLDKAAKLVIaGDARAIDMGQVNKQYCFINM---AGGGFGTEiTT 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 323 ALAEKHRWMpsnQRKDFAFIKTLADLKTEKcelSFlPLQISQEDSHendrkkkrknkkkgskdqwhkIQGDFLNVSIMAI 402
Cdd:TIGR00147 148 ETPEKLKAA---LGSLSYILSGLMRMDTLQ---PF-RCEIRGEGEH---------------------WQGEAVVFLVGNG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 403 PCLCSMapRGLAPNTRLNNGSMALIVVRNTSRTEFIKHLKRYASVKNQFSfPFVETYTVQEVKVQlriksgldakentdl 482
Cdd:TIGR00147 200 RQAGGG--QKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSDEGKHTDN-PNIIYGKASRIDIQ--------------- 261

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2024420754 483 nataAEENYPWNIDGDLVEASEVHVRVHPQLIHL 516
Cdd:TIGR00147 262 ----TPHKITFNLDGEPLGGTPFHIEILPAHLRC 291
 
Name Accession Description Interval E-value
CERK_C pfam19280
Ceramide kinase C-terminal domain; This domain is found at the C-terminus of ceramide kinase ...
 311-534 9.36e-147

Ceramide kinase C-terminal domain; This domain is found at the C-terminus of ceramide kinase enzymes. It is related to the beta sandwich domain of NAD kinases. Along with the N-terminal domain it catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This family contains ceramide kinase like proteins that lack the ceramide kinase activity. It also contains ore distantly related proteins this may have different functions.


Pssm-ID: 466025  Cd Length: 222  Bit Score: 420.26  E-value: 9.36e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 311 FSAMFGFGARTLALAEKHRWMPSNQRKDFAFIKTLADLKTEKCELSFLPLQISQEDSHENDRKKKRKNKKkgskDQWHKI 390
Cdd:pfam19280   1 FSAMFGFGGRTLALAEKHRWMSPSQRRDFAVIKTLAKLKPEDCELSFLPLNSSQDLQERKAQGSPKSDCE----EQWQTI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 391 QGDFLNVSIMAIPCLCSMAPRGLAPNTRLNNGSMALIVVRNTSRTEFIKHLKRYASVKNQFSFPFVETYTVQEVKVQLRI 470
Cdd:pfam19280  77 QGLFLNVSIMAIPCLCSMAPRGLAPNTRLNNGSMALIVVRNTSRSEFIKHLKRYASVKNQFNFPFVETYTVEEVKVRPRS 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024420754 471 KSGLDAKENTD-LNATAAEENYPWNIDGDLVE-ASEVHVRVHPQLIHLYGVNTDDLESSKATCNCI 534
Cdd:pfam19280 157 QSGWSDEESEKgTPIIASEGTYPWNIDGDLMEvASEVLIRVHPRLITLYGVSVEEMEDSKVTCSCI 222
PLN02204 PLN02204
diacylglycerol kinase
 51-517 1.21e-45

diacylglycerol kinase


Pssm-ID: 215126 [Multi-domain]  Cd Length: 601  Bit Score: 169.30  E-value: 1.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754  51 DVVLSARR--LRWSPIVPESPAGDSSTALQVKEEI---IEMKDVFSVKV---------KRRRFVGQKKGGTLLGITIFK- 115
Cdd:PLN02204   32 DVSLTLNSdgLSWKCLDSSDNDGTTCLGIKFCEKSeteIKFSDVYAVEFinyglihspKLSHAKGCFRERLSETQEMYRf 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 116 CLHK-EENKLTDCAIHLNNFSEDH-----CHSWFRRLKEILNGFQNRPKSLKVFVNPSSHKREAARIYyEQVSPLFKLAD 189
Cdd:PLN02204  112 TVHGfQRSRKEPCLWVLAVYTFGHkdlqtCQSWVDRLNASLNKEVGRPKNLLVFVHPLSGKGSGSRTW-ETVSPIFIRAK 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 190 IKTDVTVTEYEGHALSVLKEC---ELQAFDGVVCVGGDGFVSEVVHGLL---LKAQI----------DAGKGTDYIPAP- 252
Cdd:PLN02204  191 VKTKVIVTERAGHAFDVMASIsnkELKSYDGVIAVGGDGFFNEILNGYLlsrLKVPYppspsdsvhsVQSRGSSSVHEPn 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 253 --------------VRAPVP----------------------------LGVIPAGTTNILAYTLYGIKHTVTATLHIVMG 290
Cdd:PLN02204  271 etvhecdnedhsplLSDSVQevmnfrtengscegdqdsdfpfpnerfrFGIIPAGSTDAIVMCTTGERDPVTSALHIILG 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 291 HIQPVDAC--------TFSTPSRLLRFGFS-AMFGFGARTLALAEKHRWMpSNQRKDFAFIKTLADLKTEKCELSFL--P 359
Cdd:PLN02204  351 RRVCLDIAqvvrwkttSTSEIEPYVRYAASfAGYGFYGDVISESEKYRWM-GPKRYDYAGTKVFLKHRSYEAEVAYLetE 429

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 360 LQISQEDSHE-------------------------NDRKKKRKNKKKGSKDQWHKIQGDFLNVSIMAIPCLCSMAPRGLA 414
Cdd:PLN02204  430 SEKSKASSEArkrtgpkksekivcrtncsvcntkvSTNSPSTTPNSCPEETRWLRSKGRFLSVGAAIISNRNERAPDGLV 509

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 415 PNTRLNNGSMALIVVRNTSRTEFIKHLKRYASVKNQ-FSFPFVETYtvqevkvqlriksgldakENTDLNATAAEENYPW 493
Cdd:PLN02204  510 ADAHLSDGFLHLILIKDCPHPLYLWHLTQLAKRGGEpLNFEFVEHH------------------KTPAFTFTSFGDESVW 571

                         570       580
                  ....*....|....*....|....
gi 2024420754 494 NIDGDLVEASEVHVRVHPQLIHLY 517
Cdd:PLN02204  572 NLDGEIFQAHQLSAQVFRGLVNLF 595
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 156-517 2.58e-34

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 131.13  E-value: 2.58e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 156 RPKSLKVFVNPSSHkREAARIYYEQVSPLFKLADIKTDVTVTEYEGHALSVLKECELQAFDGVVCVGGDGFVSEVVHGLl 235
Cdd:COG1597     1 AMMRALLIVNPASG-RGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGL- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 236 lkaqidagkgtdyipapVRAPVPLGVIPAGTTNILAYTLyGIKHTVTATLHIVM-GHIQPVDACTFSTpsrlLRFGFSAM 314
Cdd:COG1597    79 -----------------AGTGPPLGILPLGTGNDFARAL-GIPLDPEAALEALLtGRTRRIDLGRVNG----RYFLNVAG 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 315 FGFGARTLALAEKH-RWMPSNQRKDFAFIKTLADLKTEKCELSFlplqisqeDSHEndrkkkrknkkkgskdqwhkIQGD 393
Cdd:COG1597   137 IGFDAEVVERANRAlKRRLGKLAYVLAALRALLRYRPFRLRIEL--------DGEE--------------------IEGE 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 394 FLNVSImaipCLCSMAPRG--LAPNTRLNNGSMALIVVRNTSRTEFIKHLKRYASvKNQFSFPFVETYTVQEVKVQlrik 471
Cdd:COG1597   189 ALLVAV----GNGPYYGGGlrLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLR-GRHLRHPGVRYFRAREVEIE---- 259

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 2024420754 472 sgldakentdlnataAEENYPWNIDGDLV-EASEVHVRVHPQLIHLY 517
Cdd:COG1597   260 ---------------SDRPLPVQLDGEPLgLATPLEFEVLPGALRVL 291
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
 135-431 1.86e-33

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 132.68  E-value: 1.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 135 SEDHCHSWFRRLKEILNGFqNRPKSLKVFVNPSSHKREAARIYYEQVSPLFKLADIKTDVTVTEYEGHALSVLKECELQA 214
Cdd:PLN02958   90 SDESRRLWCQKLRDYLDSL-GRPKRLLVFVNPFGGKKSASKIFFDVVKPLLEDADIQLTIQETKYQLHAKEVVRTMDLSK 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 215 FDGVVCVGGDGFVSEVVHGLLLKAQIDAGkgtdyipapvrAPVPLGVIPAGTTNILAYTLY---GIKHTVT-ATLHIVMG 290
Cdd:PLN02958  169 YDGIVCVSGDGILVEVVNGLLEREDWKTA-----------IKLPIGMVPAGTGNGMAKSLLdsvGEPCSATnAVLAIIRG 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 291 HIQPVDACTFSTPSRllRFGFSAMFGFG--ARTLALAEKHRWMPSnQRKDFAFIKTLADLKTEKCELSFLPL-------- 360
Cdd:PLN02958  238 HKCSLDVATILQGET--KFFSVLMLAWGlvADIDIESEKYRWMGS-ARLDFYGLQRILCLRQYNGRISFVPApgfeayge 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 361 -------QISQEDSHENDRKKKRKNKKKGSKDQWHKIQGDFLNVSIMAIP--CLCSMAprglAPNTRLNNGSMALIVVRN 431
Cdd:PLN02958  315 ptsyngeSTSKEESGKDKQHGYQGPDVKLENLDWRTIKGPFVSVWLHNVPwgGEDTLA----APDAKFSDGYLDLILIKD 390
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 160-299 3.20e-28

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 108.83  E-value: 3.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 160 LKVFVNPSSHKREAARIYyEQVSPLFKLADIKTDVTVTEYEGHALSVLKECELQAFDGVVCVGGDGFVSEVVHGLllkaq 239
Cdd:pfam00781   2 LLVIVNPKSGGGKGKKLL-RKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGL----- 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024420754 240 idagkgtdyipAPVRAPVPLGVIPAGTTNILAYTLyGI-KHTVTATLHIVMGHIQPVDACT 299
Cdd:pfam00781  76 -----------AGLATRPPLGIIPLGTGNDFARAL-GIpGDPEEALEAILKGQTRPVDVGK 124
PRK13337 PRK13337
putative lipid kinase; Reviewed
 158-296 1.51e-09

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 59.29  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 158 KSLKVFVNPSShKREAARIYYEQVSPLFKLADIKTDVTVTEYEGHALSVLKECELQAFDGVVCVGGDGFVSEVVHGLllk 237
Cdd:PRK13337    2 KRARIIYNPTS-GRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGI--- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024420754 238 aqidAGKgtDYIPApvrapvpLGVIPAGTTNILAYTLYGIKHTVTATLHIVMGHIQPVD 296
Cdd:PRK13337   78 ----AEK--ENRPK-------LGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVD 123
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 165-516 3.96e-09

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 57.90  E-value: 3.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 165 NPSSHKREAARIYyEQVSPLFKLADIKTDVTVTEYEGHALSVLKECELQAFDGVVCVGGDGFVSEVVHGLllkaqidagK 244
Cdd:TIGR00147   9 NPTAGKSNDNKPL-REVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNAL---------I 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 245 GTDYIPApvrapvpLGVIPAGTTNILAyTLYGIKHTVTATLHIVM-GHIQPVDACTFSTPSRLLRFgfsAMFGFGAR-TL 322
Cdd:TIGR00147  79 QLDDIPA-------LGILPLGTANDFA-RSLGIPEDLDKAAKLVIaGDARAIDMGQVNKQYCFINM---AGGGFGTEiTT 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 323 ALAEKHRWMpsnQRKDFAFIKTLADLKTEKcelSFlPLQISQEDSHendrkkkrknkkkgskdqwhkIQGDFLNVSIMAI 402
Cdd:TIGR00147 148 ETPEKLKAA---LGSLSYILSGLMRMDTLQ---PF-RCEIRGEGEH---------------------WQGEAVVFLVGNG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 403 PCLCSMapRGLAPNTRLNNGSMALIVVRNTSRTEFIKHLKRYASVKNQFSfPFVETYTVQEVKVQlriksgldakentdl 482
Cdd:TIGR00147 200 RQAGGG--QKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSDEGKHTDN-PNIIYGKASRIDIQ--------------- 261

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2024420754 483 nataAEENYPWNIDGDLVEASEVHVRVHPQLIHL 516
Cdd:TIGR00147 262 ----TPHKITFNLDGEPLGGTPFHIEILPAHLRC 291
PRK12361 PRK12361
hypothetical protein; Provisional
 143-296 1.04e-08

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 57.71  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 143 FRRLKEILN-GFQNRPKSLKVFVNPSSHKREAARiYYEQV-SPLFKLADIKTDVTVTEYEGHALSvlKECELQAFDGVVC 220
Cdd:PRK12361  227 LRALEKMLEqGKLNIHKRAWLIANPVSGGGKWQE-YGEQIqRELKAYFDLTVKLTTPEISAEALA--KQARKAGADIVIA 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 221 VGGDGFVSEVVHGLLlkaqidagkGTDyipapvrapVPLGVIPAGTTNILAYTLYGIKHTV----TATLHIVMGHIQPVD 296
Cdd:PRK12361  304 CGGDGTVTEVASELV---------NTD---------ITLGIIPLGTANALSHALFGLGSKLipveQACDNIIQGHTQRID 365
PRK00861 PRK00861
putative lipid kinase; Reviewed
 193-330 5.45e-07

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 51.55  E-value: 5.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 193 DVTVTEYEGHALSVLKECELQAFDGVVCVGGDGFVSEVVHGLLlkaqidagkGTDyipapvrapVPLGVIPAGTTNILAY 272
Cdd:PRK00861   36 DIYLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAVAGALI---------GTD---------IPLGIIPRGTANAFAA 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024420754 273 TLyGIKHTV-TATLHIVMGHIQPVDACTFS-TPSRLLrfgfsAMFGFGARTLALAE---KHRW 330
Cdd:PRK00861   98 AL-GIPDTIeEACRTILQGKTRRVDVAYCNgQPMILL-----AGIGFEAETVEEADreaKNRF 154
PRK13055 PRK13055
putative lipid kinase; Reviewed
 170-274 1.35e-06

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 50.37  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 170 KREAARIYYEQVS--PLFK--LADIKTDVTVTEYEGHA-------LSVLKECELQA---FDGVVCVGGDGFVSEVVHGLl 235
Cdd:PRK13055    1 MQKRARLIYNPTSgqEIMKknVADILDILEQAGYETSAfqttpepNSAKNEAKRAAeagFDLIIAAGGDGTINEVVNGI- 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2024420754 236 lkaqidagkgtdyipAPVRAPVPLGVIPAGTTNILAYTL 274
Cdd:PRK13055   80 ---------------APLEKRPKMAIIPAGTTNDYARAL 103
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 194-371 1.68e-06

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 49.78  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 194 VTVTEYEG----HALSVLKECELQAFDGVVCVGGDGFVSevvHGLLLKAQIDagkgtdyipapvrapVPLGVIPAGTTNI 269
Cdd:PRK11914   40 VDVVEIVGtdahDARHLVAAALAKGTDALVVVGGDGVIS---NALQVLAGTD---------------IPLGIIPAGTGND 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 270 LAYTlYGI--KHTVTATLHIVMGHIQPVDACTFSTPSRLLR-FGFSAMFGFGARTLALAEKHRWMPSNQRKDFAFIKTLA 346
Cdd:PRK11914  102 HARE-FGIptGDPEAAADVIVDGWTETVDLGRIQDDDGIVKwFGTVAATGFDSLVTDRANRMRWPHGRMRYNLAMLAELS 180

                         170       180
                  ....*....|....*....|....*
gi 2024420754 347 DLKtekcelsFLPLQISQEDSHEND 371
Cdd:PRK11914  181 KLR-------PLPFRLVLDGTEEIV 198
PRK13057 PRK13057
lipid kinase;
216-296 1.29e-03

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 41.06  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420754 216 DGVVCVGGDGFVSEVVHGLLlkaqidagkGTDyipapvrapVPLGVIPAGTTNILAYTLyGIKHTVTATLH-IVMGHIQP 294
Cdd:PRK13057   52 DLVIVGGGDGTLNAAAPALV---------ETG---------LPLGILPLGTANDLARTL-GIPLDLEAAARvIATGQVRR 112


                  ..
gi 2024420754 295 VD 296
Cdd:PRK13057  113 ID 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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