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Conserved domains on  [gi|2024420907|ref|XP_040559758|]
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coiled-coil domain-containing protein 141 isoform X3 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPEC super family cl02488
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 133-357 3.28e-06

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


The actual alignment was detected with superfamily member cd00176:

Pssm-ID: 413338 [Multi-domain]  Cd Length: 213  Bit Score: 48.98  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420907 133 FFENALEFAVKIDQVEDFLKNAQEFDNIDNLRELLLQQEHHTKELLEKSlallNKSHELTEFIEEFKREGPNANTEVIQG 212
Cdd:cd00176     5 FLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHE----ERVEALNELGEQLIEEGHPDAEEIQER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420907 213 AQSSCLKIDSLLELLQDRRRQLDRSLKHQRQgLEQVLQICLW-HQQENQVTSwykknirdyihkQNLGSSLLENEELLKE 291
Cdd:cd00176    81 LEELNQRWEELRELAEERRQRLEEALDLQQF-FRDADDLEQWlEEKEAALAS------------EDLGKDLESVEELLKK 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024420907 292 HKEMEVRLKEWSSTVEQLEAEAVKILLSEDYTEKEHLNLSSQKIHLLRGEVCCHMEERKALLQEAN 357
Cdd:cd00176   148 HKELEEELEAHEPRLKSLNELAEELLEEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEEAL 213
 
Name Accession Description Interval E-value
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 133-357 3.28e-06

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 48.98  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420907 133 FFENALEFAVKIDQVEDFLKNAQEFDNIDNLRELLLQQEHHTKELLEKSlallNKSHELTEFIEEFKREGPNANTEVIQG 212
Cdd:cd00176     5 FLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHE----ERVEALNELGEQLIEEGHPDAEEIQER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420907 213 AQSSCLKIDSLLELLQDRRRQLDRSLKHQRQgLEQVLQICLW-HQQENQVTSwykknirdyihkQNLGSSLLENEELLKE 291
Cdd:cd00176    81 LEELNQRWEELRELAEERRQRLEEALDLQQF-FRDADDLEQWlEEKEAALAS------------EDLGKDLESVEELLKK 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024420907 292 HKEMEVRLKEWSSTVEQLEAEAVKILLSEDYTEKEHLNLSSQKIHLLRGEVCCHMEERKALLQEAN 357
Cdd:cd00176   148 HKELEEELEAHEPRLKSLNELAEELLEEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEEAL 213
 
Name Accession Description Interval E-value
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 133-357 3.28e-06

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 48.98  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420907 133 FFENALEFAVKIDQVEDFLKNAQEFDNIDNLRELLLQQEHHTKELLEKSlallNKSHELTEFIEEFKREGPNANTEVIQG 212
Cdd:cd00176     5 FLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHE----ERVEALNELGEQLIEEGHPDAEEIQER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420907 213 AQSSCLKIDSLLELLQDRRRQLDRSLKHQRQgLEQVLQICLW-HQQENQVTSwykknirdyihkQNLGSSLLENEELLKE 291
Cdd:cd00176    81 LEELNQRWEELRELAEERRQRLEEALDLQQF-FRDADDLEQWlEEKEAALAS------------EDLGKDLESVEELLKK 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024420907 292 HKEMEVRLKEWSSTVEQLEAEAVKILLSEDYTEKEHLNLSSQKIHLLRGEVCCHMEERKALLQEAN 357
Cdd:cd00176   148 HKELEEELEAHEPRLKSLNELAEELLEEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEEAL 213
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 52-238 3.02e-05

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 46.28  E-value: 3.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420907  52 EIGSNQDETRKLLQDHELLLTKLKALEDKVWDLLHEADKAAEENKEKSQVYDAMAETLGDAWDTLIIMLEKRQALLELTM 131
Cdd:cd00176    27 DYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELRELAEERRQRLEEAL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024420907 132 ---VFFENALEFAVKIDQVEDFLKNAQEFDNIDNLRELLLQQEHHTKELLEKSlallNKSHELTEFIEEFKREGPNANTE 208
Cdd:cd00176   107 dlqQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHE----PRLKSLNELAEELLEEGHPDADE 182

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2024420907 209 VIQGAQSSCL-KIDSLLELLQDRRRQLDRSL 238
Cdd:cd00176   183 EIEEKLEELNeRWEELLELAEERQKKLEEAL 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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