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Conserved domains on  [gi|2032734931|ref|XP_041322451|]
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ankyrin repeat and SOCS box protein 14 [Pyrgilauda ruficollis]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-303 3.60e-45

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 161.66  E-value: 3.60e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  55 IIAAIRTGQEEALKKLVRHSSAFEEADQQGWLPVHEAAAQLNKNILEITLKASRDItwEQSTLKGETPLLVAVRNCFVDN 134
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI--NAKDDGGNTLLHAAARNGDLEI 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 135 VHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPR 214
Cdd:COG0666   103 VKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 215 SGYGLTPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYR 294
Cdd:COG0666   183 DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262

                  ....*....
gi 2032734931 295 GHFLALKYL 303
Cdd:COG0666   263 GAALIVKLL 271
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
531-587 7.04e-36

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239700  Cd Length: 57  Bit Score: 128.43  E-value: 7.04e-36
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2032734931 531 TNPRSLKHLCRLKIRACMGRLRLRCPVFMTFLPLPNCLKDYILYKEYDLYGQENYTG 587
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQGIFTG 57
PHA02875 super family cl31516
ankyrin repeat protein; Provisional
185-448 1.71e-13

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA02875:

Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 1.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 185 ERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEImelllqkgadvlsqamdcasilfeaagggnp 264
Cdd:PHA02875    2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEA------------------------------- 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 265 dsVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPVTDFS--AIKESGISPVHSAAAGAHPQCLEFLLQSGFDA 342
Cdd:PHA02875   51 --IKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAddVFYKDGMTPLHLATILKKLDIMKLLIARGADP 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 343 NFMlaqrvrkgyDDHRKSALYFAVSNGDICSTQLLLSAGALTN-QDPINC--LQIALRMGNYELMNLLLRHGANVNYFCR 419
Cdd:PHA02875  129 DIP---------NTDKFSPLHLAVMMGDIKGIELLIDHKACLDiEDCCGCtpLIIAMAKGDIAICKMLLDSGANIDYFGK 199
                         250       260       270
                  ....*....|....*....|....*....|.
gi 2032734931 420 VNTThfpSALQYALKDEV--MLRMLLNYGYD 448
Cdd:PHA02875  200 NGCV---AALCYAIENNKidIVRLFIKRGAD 227
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-303 3.60e-45

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 161.66  E-value: 3.60e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  55 IIAAIRTGQEEALKKLVRHSSAFEEADQQGWLPVHEAAAQLNKNILEITLKASRDItwEQSTLKGETPLLVAVRNCFVDN 134
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI--NAKDDGGNTLLHAAARNGDLEI 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 135 VHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPR 214
Cdd:COG0666   103 VKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 215 SGYGLTPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYR 294
Cdd:COG0666   183 DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262

                  ....*....
gi 2032734931 295 GHFLALKYL 303
Cdd:COG0666   263 GAALIVKLL 271
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
531-587 7.04e-36

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 128.43  E-value: 7.04e-36
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2032734931 531 TNPRSLKHLCRLKIRACMGRLRLRCPVFMTFLPLPNCLKDYILYKEYDLYGQENYTG 587
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQGIFTG 57
PHA03100 PHA03100
ankyrin repeat protein; Provisional
121-345 1.01e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 88.95  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 121 TPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVI-----AIKLDSYDIASLLLRSGARVNLRCVHERTALHEAA-- 193
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAIsk 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 194 RLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGH--TEIMELLLQKGADVlsqamdcasilfeaaggGNPDSVSLLL 271
Cdd:PHA03100  117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDI-----------------NAKNRVNYLL 179
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2032734931 272 EYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPV-TDFSAIKESGISPVHSAAAGAHPQCLEFLLQSGFDANFM 345
Cdd:PHA03100  180 SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLgANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI 254
Ank_2 pfam12796
Ankyrin repeats (3 copies);
123-214 1.43e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 1.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 123 LLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLrSGARVNLRCvHERTALHEAARLGRKDLVQ 202
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78
                          90
                  ....*....|..
gi 2032734931 203 LLLESGADPDPR 214
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA02875 PHA02875
ankyrin repeat protein; Provisional
185-448 1.71e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 1.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 185 ERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEImelllqkgadvlsqamdcasilfeaagggnp 264
Cdd:PHA02875    2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEA------------------------------- 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 265 dsVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPVTDFS--AIKESGISPVHSAAAGAHPQCLEFLLQSGFDA 342
Cdd:PHA02875   51 --IKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAddVFYKDGMTPLHLATILKKLDIMKLLIARGADP 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 343 NFMlaqrvrkgyDDHRKSALYFAVSNGDICSTQLLLSAGALTN-QDPINC--LQIALRMGNYELMNLLLRHGANVNYFCR 419
Cdd:PHA02875  129 DIP---------NTDKFSPLHLAVMMGDIKGIELLIDHKACLDiEDCCGCtpLIIAMAKGDIAICKMLLDSGANIDYFGK 199
                         250       260       270
                  ....*....|....*....|....*....|.
gi 2032734931 420 VNTThfpSALQYALKDEV--MLRMLLNYGYD 448
Cdd:PHA02875  200 NGCV---AALCYAIENNKidIVRLFIKRGAD 227
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
532-573 2.85e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.33  E-value: 2.85e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2032734931 532 NPRSLKHLCRLKIRACMGRlrlRCPVFMTFLPLPNCLKDYIL 573
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGK---RRLGAIDKLPLPPLLKDYLL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
120-247 4.46e-11

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 65.80  E-value: 4.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 120 ETPLLVAVRNCFVDNVHFLLL-NGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGAR-VNLRCVHE----RTALHEAA 193
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqgETALHIAV 97
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2032734931 194 RLGRKDLVQLLLESGADP-DPRSG-------------YGLTPLALAAQMGHTEIMELLLQKGADVLSQ 247
Cdd:cd22192    98 VNQNLNLVRELIARGADVvSPRATgtffrpgpknliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQ 165
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
269-450 5.91e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 5.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 269 LLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPVTDFSAIKESGISPVHSAAAGAHPQCLEFLLQSGFDANFMLaq 348
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK-- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 349 rvrkgyDDHRKSALYFAVSNGDICSTQLLLSAGA---LTNQDPINCLQIALRMGNYELMNLLLRHGANVNYFCRVNTThf 425
Cdd:COG0666    84 ------DDGGNTLLHAAARNGDLEIVKLLLEAGAdvnARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT-- 155
                         170       180
                  ....*....|....*....|....*..
gi 2032734931 426 psALQYALK--DEVMLRMLLNYGYDVH 450
Cdd:COG0666   156 --PLHLAAAngNLEIVKLLLEAGADVN 180
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
534-575 1.17e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.87  E-value: 1.17e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2032734931  534 RSLKHLCRLKIRACMGrlrlrcpvFMTFLPLPNCLKDYILYK 575
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
321-415 2.32e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 321 HSAAAGAHPQCLEFLLQSGFDANFMlaqrvrkgyDDHRKSALYFAVSNGDICSTQLLLSAGALTNQDP-INCLQIALRMG 399
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNgRTALHYAARSG 72
                          90
                  ....*....|....*.
gi 2032734931 400 NYELMNLLLRHGANVN 415
Cdd:pfam12796  73 HLEIVKLLLEKGADIN 88
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
119-235 7.60e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 55.47  E-value: 7.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 119 GETpLLVAVRNCFVDNVHFLLL-------NGCNPNVKNEE-------GDSPLVIAIKLDSYDIASLLLRSGARVNLRCV- 183
Cdd:TIGR00870  82 GDT-LLHAISLEYVDAVEAILLhllaafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASVPARACg 160
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2032734931 184 -------------HERTALHEAARLGRKDLVQLLLESGADPdprsgygLTPLALAAQMGHTEIME 235
Cdd:TIGR00870 161 dffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPADI-------LTADSLGNTLLHLLVME 218
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
217-244 3.32e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.32e-04
                           10        20
                   ....*....|....*....|....*...
gi 2032734931  217 YGLTPLALAAQMGHTEIMELLLQKGADV 244
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
390-416 6.16e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.16e-03
                           10        20
                   ....*....|....*....|....*..
gi 2032734931  390 NCLQIALRMGNYELMNLLLRHGANVNY 416
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-303 3.60e-45

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 161.66  E-value: 3.60e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  55 IIAAIRTGQEEALKKLVRHSSAFEEADQQGWLPVHEAAAQLNKNILEITLKASRDItwEQSTLKGETPLLVAVRNCFVDN 134
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI--NAKDDGGNTLLHAAARNGDLEI 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 135 VHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPR 214
Cdd:COG0666   103 VKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 215 SGYGLTPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYR 294
Cdd:COG0666   183 DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262

                  ....*....
gi 2032734931 295 GHFLALKYL 303
Cdd:COG0666   263 GAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
66-349 3.60e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 158.96  E-value: 3.60e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  66 ALKKLVRHSSAFEEADQQGWLPVHEAAAQLNKNILEITLKASRDITWEQSTLKGETPLLVAVRNCFVDNVHFLLLNGCNP 145
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 146 NVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALA 225
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 226 AQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVP 305
Cdd:COG0666   161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2032734931 306 VT-DFSAIKESGISPVHSAAAGAHPQCLEFLLQSGFDANFMLAQR 349
Cdd:COG0666   241 AGaDLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-288 6.95e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.71  E-value: 6.95e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  55 IIAAIRTGQEEALKKLVRHSSAFEEADQQGWLPVHEAAAQLNKNILEITLKASRDItwEQSTLKGETPLLVAVRNCFVDN 134
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADV--NARDKDGETPLHLAAYNGNLEI 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 135 VHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPR 214
Cdd:COG0666   136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2032734931 215 SGYGLTPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPI 288
Cdd:COG0666   216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-416 2.50e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.39  E-value: 2.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  99 ILEITLKASRDITWEQSTLKGETPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARV 178
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 179 NLRCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEA 258
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 259 AGGGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVpvtdfsaikesgispvhsaAAGAhpqclefllqs 338
Cdd:COG0666   161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL-------------------EAGA----------- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 339 gfDANFmlaqrvrkgYDDHRKSALYFAVSNGDICSTQLLLSAGALTNQDPINCLQ---IALRMGNYELMNLLLRHGANVN 415
Cdd:COG0666   211 --DVNA---------KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTallLAAAAGAALIVKLLLLALLLLA 279

                  .
gi 2032734931 416 Y 416
Cdd:COG0666   280 A 280
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
531-587 7.04e-36

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 128.43  E-value: 7.04e-36
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2032734931 531 TNPRSLKHLCRLKIRACMGRLRLRCPVFMTFLPLPNCLKDYILYKEYDLYGQENYTG 587
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQGIFTG 57
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
532-583 5.72e-19

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 80.65  E-value: 5.72e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2032734931 532 NPRSLKHLCRLKIRACMGRLRLRCPVFMTFLPLPNCLKDYILYKEYDLYGQE 583
Cdd:cd03731     2 NPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQE 53
PHA03100 PHA03100
ankyrin repeat protein; Provisional
121-345 1.01e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 88.95  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 121 TPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVI-----AIKLDSYDIASLLLRSGARVNLRCVHERTALHEAA-- 193
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAIsk 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 194 RLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGH--TEIMELLLQKGADVlsqamdcasilfeaaggGNPDSVSLLL 271
Cdd:PHA03100  117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDI-----------------NAKNRVNYLL 179
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2032734931 272 EYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPV-TDFSAIKESGISPVHSAAAGAHPQCLEFLLQSGFDANFM 345
Cdd:PHA03100  180 SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLgANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI 254
Ank_2 pfam12796
Ankyrin repeats (3 copies);
123-214 1.43e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 1.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 123 LLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLrSGARVNLRCvHERTALHEAARLGRKDLVQ 202
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78
                          90
                  ....*....|..
gi 2032734931 203 LLLESGADPDPR 214
Cdd:pfam12796  79 LLLEKGADINVK 90
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
532-575 2.30e-17

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 75.61  E-value: 2.30e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2032734931 532 NPRSLKHLCRLKIRACMGRlrlRCPVFMTFLPLPNCLKDYILYK 575
Cdd:cd03716     2 TPRSLQHLCRLAIRRCLGR---RRLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
189-279 3.75e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.69  E-value: 3.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 189 LHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLLQKgADVLSQAMDCaSILFEAAGGGNPDSVS 268
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78
                          90
                  ....*....|.
gi 2032734931 269 LLLEYGADANV 279
Cdd:pfam12796  79 LLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
156-247 4.26e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.69  E-value: 4.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 156 LVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESgADPDPRSgYGLTPLALAAQMGHTEIME 235
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78
                          90
                  ....*....|..
gi 2032734931 236 LLLQKGADVLSQ 247
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
121-323 2.11e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 81.93  E-value: 2.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 121 TPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERtalheaarlgRKDL 200
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPIPCI----------EKDM 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 201 VQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADANVP 280
Cdd:PHA02874  107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2032734931 281 KHSGHLPIHRAAYRGHFLALKYLVPVTDFSAIK-ESGISPVHSA 323
Cdd:PHA02874  187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNA 230
PHA02875 PHA02875
ankyrin repeat protein; Provisional
120-279 4.36e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 80.81  E-value: 4.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 120 ETPLLVAVRNCFVDNVHFLLLNGCNPN-VKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRK 198
Cdd:PHA02875   69 ESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 199 DLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLLQKGA--DVLSQAmDCASILFEAAGGGNPDSVSLLLEYGAD 276
Cdd:PHA02875  149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAniDYFGKN-GCVAALCYAIENNKIDIVRLFIKRGAD 227

                  ...
gi 2032734931 277 ANV 279
Cdd:PHA02875  228 CNI 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
96-257 7.63e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.09  E-value: 7.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  96 NKNILEITLKASRDItwEQSTLKGETPLLVAVRNCFVDN--VHFLLLNGCNPNVKNEEGDSPLVIAIK--LDSYDIASLL 171
Cdd:PHA03100   85 VKEIVKLLLEYGANV--NAPDNNGITPLLYAISKKSNSYsiVEYLLDNGANVNIKNSDGENLLHLYLEsnKIDLKILKLL 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 172 LRSGARVNLRCVHER----------------TALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIME 235
Cdd:PHA03100  163 IDKGVDINAKNRVNYllsygvpinikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFK 242
                         170       180
                  ....*....|....*....|..
gi 2032734931 236 LLLQKGADVlsQAMDCASILFE 257
Cdd:PHA03100  243 LLLNNGPSI--KTIIETLLYFK 262
PHA02874 PHA02874
ankyrin repeat protein; Provisional
146-444 8.54e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 80.01  E-value: 8.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 146 NVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDprsgygltplALA 225
Cdd:PHA02874   29 NISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTS----------ILP 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 226 AQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVP 305
Cdd:PHA02874   99 IPCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 306 VTDFSAIKESGI-SPVHSAAAGAHPQCLEFLLQSGfdANFMLaqRVRKGYDD------HRKSALYFAVSNGDICSTQLll 378
Cdd:PHA02874  179 KGAYANVKDNNGeSPLHNAAEYGDYACIKLLIDHG--NHIMN--KCKNGFTPlhnaiiHNRSAIELLINNASINDQDI-- 252
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2032734931 379 sagaltnqDPINCLQIALRMG-NYELMNLLLRHGANVNyfCRVNTTHFP--SALQYALKDEVMLRMLLN 444
Cdd:PHA02874  253 --------DGSTPLHHAINPPcDIDIIDILLYHKADIS--IKDNKGENPidTAFKYINKDPVIKDIIAN 311
PHA03100 PHA03100
ankyrin repeat protein; Provisional
86-279 1.17e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 79.32  E-value: 1.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  86 LPVHEAAAQLNKNILEITLKASRDItwEQSTLKGETPL-----LVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAI 160
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADI--NSSTKNNSTPLhylsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAI 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 161 --KLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDL------------------VQLLLESGADPDPRSGYGLT 220
Cdd:PHA03100  115 skKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFT 194
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2032734931 221 PLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADANV 279
Cdd:PHA03100  195 PLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
532-575 1.55e-15

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 70.58  E-value: 1.55e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2032734931 532 NPRSLKHLCRLKIRACMGRlrlRCPVFMTFLPLPNCLKDYILYK 575
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGK---RRLDLIDKLPLPPRLKDYLLYK 41
PHA02878 PHA02878
ankyrin repeat protein; Provisional
135-279 2.43e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 78.77  E-value: 2.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 135 VHFLLLNGCNPNVKNEE-GDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDP 213
Cdd:PHA02878  150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 214 RSGYGLTPLALA-AQMGHTEIMELLLQKGADVLSQamdcASILFEAA---GGGNPDSVSLLLEYGADANV 279
Cdd:PHA02878  230 RDKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAK----SYILGLTAlhsSIKSERKLKLLLEYGADINS 295
PHA02876 PHA02876
ankyrin repeat protein; Provisional
93-291 2.22e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 76.26  E-value: 2.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  93 AQLNKNILEItLKASRDITWEQSTLKGE-------------TPLLVAVRNCFVDN-VHFLLLNGCNPNVKNEEGDSPLVI 158
Cdd:PHA02876  235 SNINKNDLSL-LKAIRNEDLETSLLLYDagfsvnsiddcknTPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYL 313
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 159 AIK--LDSYDIASLLLRsGARVNLRCVHERTALHEAARLGR-KDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIME 235
Cdd:PHA02876  314 MAKngYDTENIRTLIML-GADVNAADRLYITPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIIN 392
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2032734931 236 LLLQKGADVLSQAMDCASILFEAAGGGNP-DSVSLLLEYGADANVPKHSGHLPIHRA 291
Cdd:PHA02876  393 TLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSKNKDLSTPLHYA 449
PHA02875 PHA02875
ankyrin repeat protein; Provisional
132-345 3.76e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 74.64  E-value: 3.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 132 VDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESG--A 209
Cdd:PHA02875   15 LDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGkfA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 210 DpDPRSGYGLTPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPIH 289
Cdd:PHA02875   95 D-DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLI 173
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 290 RAAYRGHFLALKYLVP----VTDFSaiKESGISPVHSAAAGAHPQCLEFLLQSGFDANFM 345
Cdd:PHA02875  174 IAMAKGDIAICKMLLDsganIDYFG--KNGCVAALCYAIENNKIDIVRLFIKRGADCNIM 231
Ank_2 pfam12796
Ankyrin repeats (3 copies);
255-343 4.20e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 4.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 255 LFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPVTDFSaIKESGISPVHSAAAGAHPQCLEF 334
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-LKDNGRTALHYAARSGHLEIVKL 79

                  ....*....
gi 2032734931 335 LLQSGFDAN 343
Cdd:pfam12796  80 LLEKGADIN 88
PHA03095 PHA03095
ankyrin-like protein; Provisional
119-379 5.65e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 74.29  E-value: 5.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 119 GETPLLVAVRNCF---VDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDS-YDIASLLLRSGARVNLRCVHERTALHeaAR 194
Cdd:PHA03095   47 GKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLH--VY 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 195 LG----RKDLVQLLLESGADPDPRSGYGLTPLAlaAQMGHT----EIMELLLQKGADVLSQAMDCASIL------FEAag 260
Cdd:PHA03095  125 LSgfniNPKVIRLLLRKGADVNALDLYGMTPLA--VLLKSRnanvELLRLLIDAGADVYAVDDRFRSLLhhhlqsFKP-- 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 261 ggNPDSVSLLLEYGADANVPKHSGHLPIHRAAYRG---HFLALKYLVPVTDFSAIKESGISPVHSAAAGAHPQCLEFLLQ 337
Cdd:PHA03095  201 --RARIVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIA 278
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2032734931 338 SGFDANFmlaqrvrkgYDDHRKSALYFAVSNGDICSTQLLLS 379
Cdd:PHA03095  279 LGADINA---------VSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA03100 PHA03100
ankyrin repeat protein; Provisional
181-419 1.18e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.16  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 181 RCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHT-----EIMELLLQKGADVLSQAMDCASIL 255
Cdd:PHA03100   31 SYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 256 FEAAGG--GNPDSVSLLLEYGADANVPKHSGHLPIHraayrghfLALKYlvPVTDFSAIKesgispvhsaaagahpqcle 333
Cdd:PHA03100  111 LYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLH--------LYLES--NKIDLKILK-------------------- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 334 FLLQSGFDANfmLAQRV----RKGYDDHRK-----SALYFAVSNGDICSTQLLLSAGA---LTNQDPINCLQIALRMGNY 401
Cdd:PHA03100  161 LLIDKGVDIN--AKNRVnyllSYGVPINIKdvygfTPLHYAVYNNNPEFVKYLLDLGAnpnLVNKYGDTPLHIAILNNNK 238
                         250
                  ....*....|....*...
gi 2032734931 402 ELMNLLLRHGANVNYFCR 419
Cdd:PHA03100  239 EIFKLLLNNGPSIKTIIE 256
PHA02875 PHA02875
ankyrin repeat protein; Provisional
185-448 1.71e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 1.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 185 ERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEImelllqkgadvlsqamdcasilfeaagggnp 264
Cdd:PHA02875    2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEA------------------------------- 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 265 dsVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPVTDFS--AIKESGISPVHSAAAGAHPQCLEFLLQSGFDA 342
Cdd:PHA02875   51 --IKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAddVFYKDGMTPLHLATILKKLDIMKLLIARGADP 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 343 NFMlaqrvrkgyDDHRKSALYFAVSNGDICSTQLLLSAGALTN-QDPINC--LQIALRMGNYELMNLLLRHGANVNYFCR 419
Cdd:PHA02875  129 DIP---------NTDKFSPLHLAVMMGDIKGIELLIDHKACLDiEDCCGCtpLIIAMAKGDIAICKMLLDSGANIDYFGK 199
                         250       260       270
                  ....*....|....*....|....*....|.
gi 2032734931 420 VNTThfpSALQYALKDEV--MLRMLLNYGYD 448
Cdd:PHA02875  200 NGCV---AALCYAIENNKidIVRLFIKRGAD 227
PHA02874 PHA02874
ankyrin repeat protein; Provisional
95-314 1.47e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.99  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  95 LNKNILEITLKASRDITWEQSTLKgeTPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRS 174
Cdd:PHA02874  102 IEKDMIKTILDCGIDVNIKDAELK--TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEK 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 175 GARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAqMGHTEIMELLLQKgADVLSQAMDCASI 254
Cdd:PHA02874  180 GAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHNRSAIELLINN-ASINDQDIDGSTP 257
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2032734931 255 LFEAAgggNP----DSVSLLLEYGADANVPKHSGHLPIHraayrghfLALKYlvpVTDFSAIKE 314
Cdd:PHA02874  258 LHHAI---NPpcdiDIIDILLYHKADISIKDNKGENPID--------TAFKY---INKDPVIKD 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
97-320 2.06e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.67  E-value: 2.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  97 KNILEITLKASRDItwEQSTLKGETPLLVAVRN-CFVDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDS--YDIASLLLR 173
Cdd:PHA03095   63 KDIVRLLLEAGADV--NAPERCGFTPLHLYLYNaTTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLR 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 174 SGARVNLRCVHERTALHeaARLGRKD----LVQLLLESGADPDPRSGYGLTPLALAAQMGHT--EIMELLLQKGADVLSQ 247
Cdd:PHA03095  141 KGADVNALDLYGMTPLA--VLLKSRNanveLLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAAT 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 248 AMDCASILFEAAGGGNPDS--VSLLLEYGADANVPKHSGHLPIHRAAYRG------HFLALKYlvpvtDFSAIKESGISP 319
Cdd:PHA03095  219 DMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQTPLHYAAVFNnpracrRLIALGA-----DINAVSSDGNTP 293

                  .
gi 2032734931 320 V 320
Cdd:PHA03095  294 L 294
PHA03095 PHA03095
ankyrin-like protein; Provisional
166-444 2.66e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.28  E-value: 2.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 166 DIASLLLRSGARVNLRCVHERTALHEAARLG---RKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTE-IMELLLQKG 241
Cdd:PHA03095   28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIKAG 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 242 ADVLSQAMDCASILFEAAGGGN--PDSVSLLLEYGADANVPKHSGHLPIHRaayrghFLA--------LKYLVPV-TDFS 310
Cdd:PHA03095  108 ADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPLAV------LLKsrnanvelLRLLIDAgADVY 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 311 AIKESGISPVHSAAAGAHP--QCLEFLLQSGFDAnfmlAQRVRKGYDDHRKSALYFAVSNGDIcstQLLLSAGA---LTN 385
Cdd:PHA03095  182 AVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDP----AATDMLGNTPLHSMATGSSCKRSLV---LPLLIAGIsinARN 254
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2032734931 386 QDPINCLQIALRMGNYELMNLLLRHGANVNyfCRVNTTHFPSALQYALKDEVMLRMLLN 444
Cdd:PHA03095  255 RYGQTPLHYAAVFNNPRACRRLIALGADIN--AVSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA02876 PHA02876
ankyrin repeat protein; Provisional
87-288 2.99e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 69.71  E-value: 2.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  87 PVHEAA-----AQLNKNILEitlkasRDITWEQSTLKGETPLLVAVRNCF-VDNVHFLLLNGCNPNVKNEEGDSPLVIAI 160
Cdd:PHA02876  276 PLHHASqapslSRLVPKLLE------RGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQAS 349
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 161 KLDSY-DIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPL--ALAAQMGHTEImELL 237
Cdd:PHA02876  350 TLDRNkDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhfALCGTNPYMSV-KTL 428
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2032734931 238 LQKGADVLSQAMDCASILFEAAGGG-NPDSVSLLLEYGADANVPKHSGHLPI 288
Cdd:PHA02876  429 IDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL 480
PHA02878 PHA02878
ankyrin repeat protein; Provisional
118-244 7.91e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.60  E-value: 7.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 118 KGETPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEA-ARLG 196
Cdd:PHA02878  167 KGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCK 246
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2032734931 197 RKDLVQLLLESGADPDPRSG-YGLTPLALAAQmgHTEIMELLLQKGADV 244
Cdd:PHA02878  247 DYDILKLLLEHGVDVNAKSYiLGLTALHSSIK--SERKLKLLLEYGADI 293
PHA02878 PHA02878
ankyrin repeat protein; Provisional
87-225 1.25e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.21  E-value: 1.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  87 PVHEAAAQLNKNILEITLKASRDITWEQSTLKgeTPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAI-KLDSY 165
Cdd:PHA02878  171 ALHYATENKDQRLTELLLSYGANVNIPDKTNN--SPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKDY 248
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032734931 166 DIASLLLRSGARVNLRC-VHERTALHEAARLGRKdlVQLLLESGADPDPRSGYGLTPLALA 225
Cdd:PHA02878  249 DILKLLLEHGVDVNAKSyILGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSA 307
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
91-250 1.29e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 67.59  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  91 AAAQLNKNILEITLKASRDITWEQStlKGETPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASL 170
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDS--KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRI 609
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 171 LLRSGARVNLRCVHErtALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLLQKGADVLSQAMD 250
Cdd:PLN03192  610 LYHFASISDPHAAGD--LLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
532-573 2.85e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.33  E-value: 2.85e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2032734931 532 NPRSLKHLCRLKIRACMGRlrlRCPVFMTFLPLPNCLKDYIL 573
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGK---RRLGAIDKLPLPPLLKDYLL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
120-247 4.46e-11

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 65.80  E-value: 4.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 120 ETPLLVAVRNCFVDNVHFLLL-NGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGAR-VNLRCVHE----RTALHEAA 193
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqgETALHIAV 97
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2032734931 194 RLGRKDLVQLLLESGADP-DPRSG-------------YGLTPLALAAQMGHTEIMELLLQKGADVLSQ 247
Cdd:cd22192    98 VNQNLNLVRELIARGADVvSPRATgtffrpgpknliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQ 165
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
269-450 5.91e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 5.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 269 LLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPVTDFSAIKESGISPVHSAAAGAHPQCLEFLLQSGFDANFMLaq 348
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK-- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 349 rvrkgyDDHRKSALYFAVSNGDICSTQLLLSAGA---LTNQDPINCLQIALRMGNYELMNLLLRHGANVNYFCRVNTThf 425
Cdd:COG0666    84 ------DDGGNTLLHAAARNGDLEIVKLLLEAGAdvnARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT-- 155
                         170       180
                  ....*....|....*....|....*..
gi 2032734931 426 psALQYALK--DEVMLRMLLNYGYDVH 450
Cdd:COG0666   156 --PLHLAAAngNLEIVKLLLEAGADVN 180
PHA02876 PHA02876
ankyrin repeat protein; Provisional
160-450 8.45e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.70  E-value: 8.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 160 IKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLLQ 239
Cdd:PHA02876  153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 240 KGAD-----------VLSQAMDCASILFEAAGGGNPDS-------------------VSLLLEYGADANVPKHSGHLPIH 289
Cdd:PHA02876  233 NRSNinkndlsllkaIRNEDLETSLLLYDAGFSVNSIDdckntplhhasqapslsrlVPKLLERGADVNAKNIKGETPLY 312
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 290 RAAYRGHFLA-LKYLVPV-TDFSAIKESGISPVHSAAA-GAHPQCLEFLLQSGFDANfmlaqrVRKGYDdhrKSALYFAV 366
Cdd:PHA02876  313 LMAKNGYDTEnIRTLIMLgADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVN------ARDYCD---KTPIHYAA 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 367 SNGDICSTQLLLSAGA---LTNQDPINCLQIALRMGN-YELMNLLLRHGANVNyfcrVNTTHFPSALQYALKDEV---ML 439
Cdd:PHA02876  384 VRNNVVIINTLLDYGAdieALSQKIGTALHFALCGTNpYMSVKTLIDRGANVN----SKNKDLSTPLHYACKKNCkldVI 459
                         330
                  ....*....|.
gi 2032734931 440 RMLLNYGYDVH 450
Cdd:PHA02876  460 EMLLDNGADVN 470
Ank_4 pfam13637
Ankyrin repeats (many copies);
185-238 9.16e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 57.28  E-value: 9.16e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2032734931 185 ERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLL 238
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
168-266 3.18e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 62.99  E-value: 3.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 168 ASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLlqkgadvlsq 247
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL---------- 167
                          90
                  ....*....|....*....
gi 2032734931 248 aMDCASILFEAAGGGNPDS 266
Cdd:PTZ00322  168 -SRHSQCHFELGANAKPDS 185
PHA02875 PHA02875
ankyrin repeat protein; Provisional
55-243 4.55e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.93  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  55 IIAAIRTGQEEALKKLVRHSSAFEEADQQGWLPVHEAAAQLNKNILEITL---KASRDITWEqstlKGETPLLVAVRNCF 131
Cdd:PHA02875   39 IKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLdlgKFADDVFYK----DGMTPLHLATILKK 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 132 VDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADP 211
Cdd:PHA02875  115 LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194
                         170       180       190
                  ....*....|....*....|....*....|...
gi 2032734931 212 DPRSGYG-LTPLALAAQMGHTEIMELLLQKGAD 243
Cdd:PHA02875  195 DYFGKNGcVAALCYAIENNKIDIVRLFIKRGAD 227
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
535-576 7.05e-10

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 54.80  E-value: 7.05e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2032734931 535 SLKHLCRLKIRACMGRLRLRCPVFMTFLPLPNCLKDYILYKE 576
Cdd:cd03722     5 SLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSD 46
PHA02875 PHA02875
ankyrin repeat protein; Provisional
159-385 3.28e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.23  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 159 AIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLL 238
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 239 QKGA---DVLSQamDCASILFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPVTDFSAIKES 315
Cdd:PHA02875   89 DLGKfadDVFYK--DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDC 166
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032734931 316 -GISPVHSAAAGAHPQCLEFLLQSGFDANFmlaqrVRKGYDdhrKSALYFAVSNGDICSTQLLLSAGALTN 385
Cdd:PHA02875  167 cGCTPLIIAMAKGDIAICKMLLDSGANIDY-----FGKNGC---VAALCYAIENNKIDIVRLFIKRGADCN 229
PHA02878 PHA02878
ankyrin repeat protein; Provisional
199-343 5.23e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 58.74  E-value: 5.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 199 DLVQLLLESGADPDPRSGYGL-TPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLLEYGADA 277
Cdd:PHA02878  148 EITKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032734931 278 NVPKHSGHLPIHRA-AYRGHFLALKYL----VPVTDFSAIKesGISPVHSAAAGahPQCLEFLLQSGFDAN 343
Cdd:PHA02878  228 DARDKCGNTPLHISvGYCKDYDILKLLlehgVDVNAKSYIL--GLTALHSSIKS--ERKLKLLLEYGADIN 294
Ank_2 pfam12796
Ankyrin repeats (3 copies);
55-149 6.09e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 6.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  55 IIAAIRTGQEEALKKLVRHSSAFEEADQQGWLPVHEAAAQLNKNILEItLKASRDItweQSTLKGETPLLVAVRNCFVDN 134
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKL-LLEHADV---NLKDNGRTALHYAARSGHLEI 76
                          90
                  ....*....|....*
gi 2032734931 135 VHFLLLNGCNPNVKN 149
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
534-575 1.17e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.87  E-value: 1.17e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2032734931  534 RSLKHLCRLKIRACMGrlrlrcpvFMTFLPLPNCLKDYILYK 575
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
PHA02876 PHA02876
ankyrin repeat protein; Provisional
138-414 1.22e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.77  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 138 LLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVN---------LRC-------------------------- 182
Cdd:PHA02876  164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiialddlsvLECavdsknidtikaiidnrsninkndls 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 183 ---------------------------VHERTALHEAAR---LGRkdLVQLLLESGADPDPRSGYGLTPLALAAQMGH-T 231
Cdd:PHA02876  244 llkairnedletslllydagfsvnsidDCKNTPLHHASQapsLSR--LVPKLLERGADVNAKNIKGETPLYLMAKNGYdT 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 232 EIMELLLQKGADVLSQAMDCASILFEAAG-GGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLVPV-TDF 309
Cdd:PHA02876  322 ENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYgADI 401
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 310 SAIKESGISPVHSAAAGAHP-QCLEFLLQSGFDANfmlaqrvrkGYDDHRKSALYFAVSNGdiCS---TQLLLSAGALTN 385
Cdd:PHA02876  402 EALSQKIGTALHFALCGTNPyMSVKTLIDRGANVN---------SKNKDLSTPLHYACKKN--CKldvIEMLLDNGADVN 470
                         330       340       350
                  ....*....|....*....|....*....|
gi 2032734931 386 QDPI-NCLQIALRMGNYELMNLLLRHGANV 414
Cdd:PHA02876  471 AINIqNQYPLLIALEYHGIVNILLHYGAEL 500
Ank_2 pfam12796
Ankyrin repeats (3 copies);
321-415 2.32e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 321 HSAAAGAHPQCLEFLLQSGFDANFMlaqrvrkgyDDHRKSALYFAVSNGDICSTQLLLSAGALTNQDP-INCLQIALRMG 399
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNgRTALHYAARSG 72
                          90
                  ....*....|....*.
gi 2032734931 400 NYELMNLLLRHGANVN 415
Cdd:pfam12796  73 HLEIVKLLLEKGADIN 88
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
119-235 7.60e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 55.47  E-value: 7.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 119 GETpLLVAVRNCFVDNVHFLLL-------NGCNPNVKNEE-------GDSPLVIAIKLDSYDIASLLLRSGARVNLRCV- 183
Cdd:TIGR00870  82 GDT-LLHAISLEYVDAVEAILLhllaafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASVPARACg 160
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2032734931 184 -------------HERTALHEAARLGRKDLVQLLLESGADPdprsgygLTPLALAAQMGHTEIME 235
Cdd:TIGR00870 161 dffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPADI-------LTADSLGNTLLHLLVME 218
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
531-575 1.11e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 47.98  E-value: 1.11e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2032734931 531 TNPRSLKHLCRLKIRACMGRLRLRCpvfmtfLPLPNCLKDYILYK 575
Cdd:cd03717     1 TSVRSLQHLCRFVIRQCTRRDLIDQ------LPLPRRLKDYLKEY 39
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
144-276 1.86e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 54.32  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 144 NPNVKNEEGDSPL-VIAIKLDSYDIASLLLRSGARVNLrcvhERTALHeAARLGRKDLVQLLLESGADPDPRSGY----- 217
Cdd:TIGR00870  44 NINCPDRLGRSALfVAAIENENLELTELLLNLSCRGAV----GDTLLH-AISLEYVDAVEAILLHLLAAFRKSGPlelan 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 218 ---------GLTPLALAAQMGHTEIMELLLQKGADV----------LSQAMDCA----SILFEAAGGGNPDSVSLLLEYG 274
Cdd:TIGR00870 119 dqytseftpGITALHLAAHRQNYEIVKLLLERGASVparacgdffvKSQGVDSFyhgeSPLNAAACLGSPSIVALLSEDP 198

                  ..
gi 2032734931 275 AD 276
Cdd:TIGR00870 199 AD 200
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
532-573 2.10e-07

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 47.82  E-value: 2.10e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2032734931 532 NPRSLKHLCRLKIRACMGRlrlRCPVFMTFLPLPNCLKDYIL 573
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLGS---RCHKLVPQLSLPTSLKNYLL 40
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
531-575 2.26e-07

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 47.29  E-value: 2.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2032734931  531 TNPRSLKHLCRLKIRACMGRLRLRCpvfmtfLPLPNCLKDYILYK 575
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTDQIKT------LPLPPKLKDYLSYY 43
Ank_4 pfam13637
Ankyrin repeats (many copies);
251-304 2.95e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 2.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2032734931 251 CASILFEAAGGGNPDSVSLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKYLV 304
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
267-450 7.42e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 7.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 267 VSLLLEYGADAN-VPKHSGHLPIHRAAYRGHFLALKYLVPV-TDFSAIKESGISPVHSAAAGAHPQCLEFLLQSGfdanf 344
Cdd:PHA02878  150 TKLLLSYGADINmKDRHKGNTALHYATENKDQRLTELLLSYgANVNIPDKTNNSPLHHAVKHYNKPIVHILLENG----- 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 345 mlaqrvrkGYDDHRksalyfavsngDIC-STQLLLSAGaltnqdpinclqialRMGNYELMNLLLRHGANVNYfcrVNTT 423
Cdd:PHA02878  225 --------ASTDAR-----------DKCgNTPLHISVG---------------YCKDYDILKLLLEHGVDVNA---KSYI 267
                         170       180
                  ....*....|....*....|....*..
gi 2032734931 424 HFPSALQYALKDEVMLRMLLNYGYDVH 450
Cdd:PHA02878  268 LGLTALHSSIKSERKLKLLLEYGADIN 294
Ank_2 pfam12796
Ankyrin repeats (3 copies);
362-451 1.22e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.65  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 362 LYFAVSNGDICSTQLLLSAGA---LTNQDPINCLQIALRMGNYELMNLLLRHgANVNYFCRVNTthfpsALQYALK--DE 436
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAdanLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-----ALHYAARsgHL 74
                          90
                  ....*....|....*
gi 2032734931 437 VMLRMLLNYGYDVHR 451
Cdd:pfam12796  75 EIVKLLLEKGADINV 89
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
533-578 1.45e-06

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 45.22  E-value: 1.45e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2032734931 533 PRSLKHLCRLKIRACMGRLRLRcpvFMTFLPLPNCLKDYILYKEYD 578
Cdd:cd03726     3 PRTLQDLCRIKIRHCIGLQNLK---LLDELPIAKVMKDYLKHKFDD 45
PHA02874 PHA02874
ankyrin repeat protein; Provisional
58-287 1.56e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.73  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  58 AIRTGQEEALKKLVRHSSAFEEADQQGWLPVHeaaaqlnknileitlkasrditweqstlkgetpllVAVRNCFVDNVHF 137
Cdd:PHA02874  131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIH-----------------------------------IAIKHNFFDIIKL 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 138 LLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAArLGRKDLVQLLLESGADPDPRSGy 217
Cdd:PHA02874  176 LLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHNRSAIELLINNASINDQDID- 253
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032734931 218 GLTPLALAAQMG-HTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVslLLEYGADANVPKHSGHLP 287
Cdd:PHA02874  254 GSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPV--IKDIIANAVLIKEADKLK 322
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
533-575 2.34e-06

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 44.48  E-value: 2.34e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2032734931 533 PRSLKHLCRLKIRACMGRLRLRcpvFMTFLPLPNCLKDYILYK 575
Cdd:cd03724     3 PSSLCQLCRLCIRNYIGRSRLH---LIPQLQLPTLLKNFLQYR 42
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
58-240 6.92e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.86  E-value: 6.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  58 AIRTGQEEALKKLVRHSSA-FEEADQQGWLPVHEAAAQLNKNILEITLKASRDITWEQST---LKGETPLLVAVRNCFVD 133
Cdd:cd22192    24 AAKENDVQAIKKLLKCPSCdLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlYQGETALHIAVVNQNLN 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 134 NVHFLLLNGCN------------PNVKN--EEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALH----EAARL 195
Cdd:cd22192   104 LVRELIARGADvvspratgtffrPGPKNliYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHilvlQPNKT 183
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2032734931 196 GRKDLVQLLLESGADPDP------RSGYGLTPLALAAQMGHTEIMELLLQK 240
Cdd:cd22192   184 FACQMYDLILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
86-304 1.08e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  86 LPVHEAAAQLNKNILEITLKASRDITWEQSTLkGETPLLVAVrncFVDNVHF-LLLNGCNPNVKNE-------EGDSPLV 157
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGAL-GETALHVAA---LYDNLEAaVVLMEAAPELVNEpmtsdlyQGETALH 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 158 IAIKLDSYDIASLLLRSGARV---------------NLrCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPL 222
Cdd:cd22192    95 IAVVNQNLNLVRELIARGADVvspratgtffrpgpkNL-IYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 223 ALaaqmghteimeLLLQKGADVLSQAMDcasILFEAAGGGNPDSVSLlleygadanVPKHSGHLPIHRAAYRGHFLALKY 302
Cdd:cd22192   174 HI-----------LVLQPNKTFACQMYD---LILSYDKEDDLQPLDL---------VPNNQGLTPFKLAAKEGNIVMFQH 230

                  ..
gi 2032734931 303 LV 304
Cdd:cd22192   231 LV 232
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
533-576 1.20e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 42.55  E-value: 1.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2032734931 533 PRSLKHLCRLKIRACMGRLRLRcpvFMTFLPLPNCLKDYILYKE 576
Cdd:cd03721     3 PRPLAHLCRLKVRTLIGINRIK---LIDTLPLPPRLIRYLNHQE 43
Ank_5 pfam13857
Ankyrin repeats (many copies);
170-225 1.41e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 1.41e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2032734931 170 LLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALA 225
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
192-341 2.19e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.56  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 192 AARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLL 271
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032734931 272 EYGADANvPKHSGHLpIHRAAYRGHFLALKYLVPV-TDFSAIKESGISPVHSAAAGAHPQCLEFLLQSGFD 341
Cdd:PLN03192  612 HFASISD-PHAAGDL-LCTAAKRNDLTAMKELLKQgLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
Ank_4 pfam13637
Ankyrin repeats (many copies);
287-336 2.24e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 2.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2032734931 287 PIHRAAYRGHFLALKYLVPVT-DFSAIKESGISPVHSAAAGAHPQCLEFLL 336
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGaDINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
135-253 3.67e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 135 VHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDiASL---LLRSGARVNLRCVHERTALHEAARLGRKDLVQLLLESGADP 211
Cdd:PHA03095  205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCK-RSLvlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADI 283
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2032734931 212 DPRSGYGLTPLALAAQMGHTEIMELLLQK--GADVLSQAMDCAS 253
Cdd:PHA03095  284 NAVSSDGNTPLSLMVRNNNGRAVRAALAKnpSAETVAATLNTAS 327
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
533-575 3.95e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 41.13  E-value: 3.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2032734931 533 PRSLKHLCRLKIRACMGRLRLRcpvFMTFLPLPNCLKDYILYK 575
Cdd:cd03718     3 PLPLMDLCRRRVRVALGRDRLE---EIEQLPLPPSLKNYLLYQ 42
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
533-575 8.02e-05

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 40.39  E-value: 8.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2032734931 533 PRSLKHLCRLKIRACMGRLRLRcpvFMTFLPLPNCLKDYILYK 575
Cdd:cd03719     3 PHSLLHLSRLCVRHALGDTRLG---QVSALPLPPAMKRYLLYQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
218-271 8.51e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 8.51e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2032734931 218 GLTPLALAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGGNPDSVSLLL 271
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
178-304 9.66e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 45.26  E-value: 9.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 178 VNLRCVHE----RTALHEAARLGRKDLVQLLLESGADPDPRSG-------------YGLTPLALAAQMGHTEIMELLLQK 240
Cdd:cd21882    62 VNAPCTDEfyqgQTALHIAIENRNLNLVRLLVENGADVSARATgrffrkspgnlfyFGELPLSLAACTNQEEIVRLLLEN 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 241 GADVLS-QAMDCAS-----ILFEAAGGGNPDSV------SLLLEYGADAN-------VPKHSGHLPIHRAAYRGHFLALK 301
Cdd:cd21882   142 GAQPAAlEAQDSLGntvlhALVLQADNTPENSAfvcqmyNLLLSYGAHLDptqqleeIPNHQGLTPLKLAAVEGKIVMFQ 221

                  ...
gi 2032734931 302 YLV 304
Cdd:cd21882   222 HIL 224
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
186-246 1.07e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 45.13  E-value: 1.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2032734931 186 RTALHEAARLGRKDLVQLLLESGADPDPRSG--------------YGLTPLALAAQMGHTEIMELLLQKGADVLS 246
Cdd:cd22194   142 QTALNIAIERRQGDIVKLLIAKGADVNAHAKgvffnpkykhegfyFGETPLALAACTNQPEIVQLLMEKESTDIT 216
PHA02989 PHA02989
ankyrin repeat protein; Provisional
120-453 1.56e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 44.35  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 120 ETPLLVAVRNCFVDN------VHFLLLNGCNPNVKNEEGDSPLVIAI---KLDSYDIASLLLRSGARVN-LRCVHERTAL 189
Cdd:PHA02989   70 ETPLCAVLRNREITSnkikkiVKLLLKFGADINLKTFNGVSPIVCFIynsNINNCDMLRFLLSKGINVNdVKNSRGYNLL 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 190 H---EAARLgRKDLVQLLLESGADP-DPRSGYGLTPlalaaqmghteiMELLLQKGADVLSQAMdcasILFEAAGGGNPD 265
Cdd:PHA02989  150 HmylESFSV-KKDVIKILLSFGVNLfEKTSLYGLTP------------MNIYLRNDIDVISIKV----IKYLIKKGVNIE 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 266 SVSLLLEYGADAnvpkhsgHLPIHRAAYRGHFLALKYLVPVTDFSAIKESGISPVHSAAAGAHPQCLEFLLQSGFDanfm 345
Cdd:PHA02989  213 TNNNGSESVLES-------FLDNNKILSKKEFKVLNFILKYIKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDD---- 281
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 346 laqrvrkgyddhrksaLYFAVSNGDICSTqlllsagaltnqdpinclqIALRMGNYELMNLLLRHGANvNYFCRVNTTHF 425
Cdd:PHA02989  282 ----------------IYNVSKDGDTVLT-------------------YAIKHGNIDMLNRILQLKPG-KYLIKKTFEYF 325
                         330       340       350
                  ....*....|....*....|....*....|..
gi 2032734931 426 P----SALQYALKDEVMLRMLLNYGYDVHRCF 453
Cdd:PHA02989  326 SehgiNDLFFNEKKMLMMILLMQYSFTIYPIF 357
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
217-247 1.98e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 1.98e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2032734931 217 YGLTPLALAA-QMGHTEIMELLLQKGADVLSQ 247
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNAR 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
56-222 2.38e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  56 IAAIRTGQEEALKKLVRHSSAFEEADQqgwlpVHEAAAQLNKNI--LEITLKASRDITWEQSTLKGETPL---LVAVRNC 130
Cdd:PTZ00322   13 FAAQLFFGTEGSRKRRAKPISFERMAA-----IQEEIARIDTHLeaLEATENKDATPDHNLTTEEVIDPVvahMLTVELC 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 131 FV----DNV--HFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLL 204
Cdd:PTZ00322   88 QLaasgDAVgaRILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
                         170       180
                  ....*....|....*....|....*
gi 2032734931 205 L-------ESGADPDPRSGYGLTPL 222
Cdd:PTZ00322  168 SrhsqchfELGANAKPDSFTGKPPS 192
PHA02878 PHA02878
ankyrin repeat protein; Provisional
58-161 2.63e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 43.72  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931  58 AIRTGQEEALKKLVRHSSAFEEADQQGWLPVHEAAAQ-LNKNILEITLKASRDITwEQSTLKGETPLLVAVRNcfVDNVH 136
Cdd:PHA02878  208 AVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVN-AKSYILGLTALHSSIKS--ERKLK 284
                          90       100
                  ....*....|....*....|....*
gi 2032734931 137 FLLLNGCNPNVKNEEGDSPLVIAIK 161
Cdd:PHA02878  285 LLLEYGADINSLNSYKLTPLSSAVK 309
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
533-575 2.90e-04

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 38.81  E-value: 2.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2032734931 533 PRSLKHLCRLKIRACMGRLRLRcpvFMTFLPLPNCLKDYILYK 575
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLS---EIHTLPLPASLKNYLLYQ 42
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
533-575 2.98e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 38.78  E-value: 2.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2032734931 533 PRSLKHLCRLKIRACMGRLRLRcpvFMTFLPLPNCLKDYILYK 575
Cdd:cd03743     3 PLPLMDLCRRSARQALGRHRLH---HIQSLPLPQTLKNYLQYQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
121-172 3.09e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 3.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2032734931 121 TPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIAIKLDSYDIASLLL 172
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
217-244 3.32e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.32e-04
                           10        20
                   ....*....|....*....|....*...
gi 2032734931  217 YGLTPLALAAQMGHTEIMELLLQKGADV 244
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
531-577 4.62e-04

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 37.91  E-value: 4.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2032734931 531 TNPRSLKHLCRLKIRACMGRLRLrcpvfmtfLPLPNCLKDYIlyKEY 577
Cdd:cd03736     1 TSTPSLQHLCRITINKCTRQIQE--------LPLPTRLKDYL--TEY 37
Ank_4 pfam13637
Ankyrin repeats (many copies);
152-205 4.76e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 4.76e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2032734931 152 GDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEAARLGRKDLVQLLL 205
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
184-212 6.63e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 6.63e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2032734931 184 HERTALHEAA-RLGRKDLVQLLLESGADPD 212
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
184-212 7.52e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.24  E-value: 7.52e-04
                          10        20
                  ....*....|....*....|....*....
gi 2032734931 184 HERTALHEAARLGRKDLVQLLLESGADPD 212
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
533-573 8.99e-04

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 37.42  E-value: 8.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2032734931 533 PRSLKHLCRLKIRACMGRLRLRCPVfmTFLPLPNCLKDYIL 573
Cdd:cd03725     3 PPPLKHLCRVFIRLCLRPWPVDVKV--KALPLPDRLKWYLL 41
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
184-212 2.01e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 2.01e-03
                           10        20
                   ....*....|....*....|....*....
gi 2032734931  184 HERTALHEAARLGRKDLVQLLLESGADPD 212
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
534-577 2.04e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 36.24  E-value: 2.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2032734931 534 RSLKHLCRLKIRACMGRLRLRcpvfmtFLPLPNCLKDYILYKEY 577
Cdd:cd03740     4 RSLQYLCRFVIRQYTRIDLIQ------KLPLPNKMKGYLLEKHY 41
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
532-574 2.58e-03

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 35.86  E-value: 2.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2032734931 532 NPRSLKHLCRLKIRACMGRLRLRcpvFMTFLPLPNCLKDYILY 574
Cdd:cd03720     2 NPRSLLSLCRIAVRRALGKQRLS---LICSLPLPDPIKKFLLH 41
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
217-244 3.42e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 3.42e-03
                          10        20
                  ....*....|....*....|....*...
gi 2032734931 217 YGLTPLALAAQMGHTEIMELLLQKGADV 244
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
PHA02859 PHA02859
ankyrin repeat protein; Provisional
131-298 3.66e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.03  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 131 FVDNVHFLLLNGCNP-----------NVK---------NEEGDSPLVIAIKLD--SYDIASLLLRSGARVNLRCVHER-T 187
Cdd:PHA02859   10 YNDFTDYLFYRYCNPlfyyvekddieGVKkwikfvndcNDLYETPIFSCLEKDkvNVEILKFLIENGADVNFKTRDNNlS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 188 ALHEAARLGRK---DLVQLLLESGADPDPRSGYGLTPLA--LAAQMGHTEIMELLLQKGADVLSQAMDCASILFEAAGGG 262
Cdd:PHA02859   90 ALHHYLSFNKNvepEILKILIDSGSSITEEDEDGKNLLHmyMCNFNVRINVIKLLIDSGVSFLNKDFDNNNILYSYILFH 169
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2032734931 263 NPDSVS-LLLEYGADANVPKHSGHLPIHRAAYRGHFL 298
Cdd:PHA02859  170 SDKKIFdFLTSLGIDINETNKSGYNCYDLIKFRNLFF 206
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
532-577 3.71e-03

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 35.84  E-value: 3.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2032734931 532 NPRSLKHLCRLKIRAcMGRLRLrcpvfMTFLPLPNCLKDYILYKEY 577
Cdd:cd03741     2 NVQSLQHLCRFVIRK-LVRRDH-----IPALPLPRRLIDYLREKHY 41
Ank_5 pfam13857
Ankyrin repeats (many copies);
138-192 4.28e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 4.28e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2032734931 138 LLLNG-CNPNVKNEEGDSPLVIAIKLDSYDIASLLLRSGARVNLRCVHERTALHEA 192
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
533-575 4.51e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 35.20  E-value: 4.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2032734931 533 PRSLKHLCRLKIRACMGRLRLrcPVFMTFLPLPNCLKDYILYK 575
Cdd:cd03727     3 PGTLKALARYAVRRSLGVQYL--PEAVKQLPLPRSVKEYLLLL 43
PHA02917 PHA02917
ankyrin-like protein; Provisional
187-238 4.72e-03

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 39.98  E-value: 4.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2032734931 187 TALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAA-QMGHTEIMELLL 238
Cdd:PHA02917  454 TLLHKAVRYNKQSLVSLLLESGSDVNIRSNNGYTCIAIAInESRNIELLKMLL 506
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
532-575 5.30e-03

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 35.15  E-value: 5.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2032734931 532 NPRSLKHLCRLKIRACMGRlrlRCPVFMTFLPLPNCLKDYILYK 575
Cdd:cd03729     2 TPLSLQQLCRINLRKALGT---RALEKIAKLNIPNRIIDYLSYN 42
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
533-575 5.88e-03

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 34.77  E-value: 5.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2032734931 533 PRSLKHLCRLKIRACMGRlrlRCPVFMTFLPLPNCLKDYILYK 575
Cdd:cd03728     3 PPSLMQLCRLCIRKCFGR---KQHHKIHKLHLPEPLKHFLLYR 42
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
390-416 6.16e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.16e-03
                           10        20
                   ....*....|....*....|....*..
gi 2032734931  390 NCLQIALRMGNYELMNLLLRHGANVNY 416
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02791 PHA02791
ankyrin-like protein; Provisional
107-240 7.83e-03

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 38.48  E-value: 7.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032734931 107 SRDITWEQSTLKGetplLVAVRNCFVDNVHflllngcnpnvkneeGDSPLVIAIKLDSYDIASLLLRSGARVNLrcVHER 186
Cdd:PHA02791    4 SRINTWKSKQLKS----FLSSKDAFKADVH---------------GHSALYYAIADNNVRLVCTLLNAGALKNL--LENE 62
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2032734931 187 TALHEAARLGRKDLVQLLLESGADPDPRSGYGLTPLALAAQMGHTEIMELLLQK 240
Cdd:PHA02791   63 FPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAVDSGNMQTVKLFVKK 116
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
118-147 8.45e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 8.45e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2032734931 118 KGETPLLVAVRNCFVDNVHFLLLNGCNPNV 147
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
115-159 9.33e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 9.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2032734931 115 STLKGETPLLVAVRNCFVDNVHFLLLNGCNPNVKNEEGDSPLVIA 159
Cdd:pfam13857  12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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