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Conserved domains on  [gi|2113776190|ref|XP_044166288|]
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uncharacterized protein LOC122950280 [Acropora millepora]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 39-121 5.46e-21

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 461662  Cd Length: 76  Bit Score: 84.51  E-value: 5.46e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113776190  39 CCVPFCNATSKKNKSLRFHRFPKKKGLKDRWIAKIRRDEgdyFAVTENTRVCSKHFCEEDYTVSedgkGKKIVLKKGAVP 118
Cdd:pfam05485   1 CSVPGCTNRKKKNPRTSFHKFPKDPERRKKWLNACKRKD---LPPPSNSYVCSLHFEENDFEKS----GGKRKLKPGAIP 73


                  ...
gi 2113776190 119 TIF 121
Cdd:pfam05485  74 TLF 76
DDE_Tnp_4 super family cl48181
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 216-271 1.45e-07

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


The actual alignment was detected with superfamily member pfam13359:

Pssm-ID: 463855 [Multi-domain]  Cd Length: 158  Bit Score: 49.97  E-value: 1.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2113776190 216 FNNKDQLIRFY--TDKAQFNEEEVENTQSVASVHIHVERAISRIKM-YKIITNVVPLSL 271
Cdd:pfam13359  84 FPISDWLLVPYkkPGGAQLSPEEVEFNRRIASARIHVERVIGRLKGrFRILRGRLPISL 142
 
Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 39-121 5.46e-21

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 84.51  E-value: 5.46e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113776190  39 CCVPFCNATSKKNKSLRFHRFPKKKGLKDRWIAKIRRDEgdyFAVTENTRVCSKHFCEEDYTVSedgkGKKIVLKKGAVP 118
Cdd:pfam05485   1 CSVPGCTNRKKKNPRTSFHKFPKDPERRKKWLNACKRKD---LPPPSNSYVCSLHFEENDFEKS----GGKRKLKPGAIP 73


                  ...
gi 2113776190 119 TIF 121
Cdd:pfam05485  74 TLF 76
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 39-121 2.20e-20

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 82.87  E-value: 2.20e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113776190   39 CCVPFCNATSKKNKSLRFHRFPKK-KGLKDRWIAKIRRDEGDYFAVTENTRVCSKHFCEEDYTVSedgkgkKIVLKKGAV 117
Cdd:smart00980   2 CCVPGCGNRSKKNPGLSFFRFPKEdPELRKKWLENLGLPDDPNRKPKKRSRICSRHFEPDDFDNS------GRRLKPGAV 75


                   ....
gi 2113776190  118 PTIF 121
Cdd:smart00980  76 PTLF 79
DDE_Tnp_4 pfam13359
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 216-271 1.45e-07

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


Pssm-ID: 463855 [Multi-domain]  Cd Length: 158  Bit Score: 49.97  E-value: 1.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2113776190 216 FNNKDQLIRFY--TDKAQFNEEEVENTQSVASVHIHVERAISRIKM-YKIITNVVPLSL 271
Cdd:pfam13359  84 FPISDWLLVPYkkPGGAQLSPEEVEFNRRIASARIHVERVIGRLKGrFRILRGRLPISL 142
 
Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 39-121 5.46e-21

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 84.51  E-value: 5.46e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113776190  39 CCVPFCNATSKKNKSLRFHRFPKKKGLKDRWIAKIRRDEgdyFAVTENTRVCSKHFCEEDYTVSedgkGKKIVLKKGAVP 118
Cdd:pfam05485   1 CSVPGCTNRKKKNPRTSFHKFPKDPERRKKWLNACKRKD---LPPPSNSYVCSLHFEENDFEKS----GGKRKLKPGAIP 73


                  ...
gi 2113776190 119 TIF 121
Cdd:pfam05485  74 TLF 76
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 39-121 2.20e-20

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 82.87  E-value: 2.20e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113776190   39 CCVPFCNATSKKNKSLRFHRFPKK-KGLKDRWIAKIRRDEGDYFAVTENTRVCSKHFCEEDYTVSedgkgkKIVLKKGAV 117
Cdd:smart00980   2 CCVPGCGNRSKKNPGLSFFRFPKEdPELRKKWLENLGLPDDPNRKPKKRSRICSRHFEPDDFDNS------GRRLKPGAV 75


                   ....
gi 2113776190  118 PTIF 121
Cdd:smart00980  76 PTLF 79
DDE_Tnp_4 pfam13359
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 216-271 1.45e-07

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


Pssm-ID: 463855 [Multi-domain]  Cd Length: 158  Bit Score: 49.97  E-value: 1.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2113776190 216 FNNKDQLIRFY--TDKAQFNEEEVENTQSVASVHIHVERAISRIKM-YKIITNVVPLSL 271
Cdd:pfam13359  84 FPISDWLLVPYkkPGGAQLSPEEVEFNRRIASARIHVERVIGRLKGrFRILRGRLPISL 142
DM3 smart00692
Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;
56-122 1.97e-07

Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;


Pssm-ID: 128933  Cd Length: 59  Bit Score: 46.92  E-value: 1.97e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2113776190   56 FHRFPKKKGLKDRWIAKIRRDegDYFAVTENTRVCSKHFCEEDYtvsedgkGKKIVLKKGAVPTIFK 122
Cdd:smart00692   1 LFRFPKDPELLKKWEHNLRLS--PDEKKLKNSRICSRHFEPECF-------GKRRRLKPGAVPTLEL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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