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Conserved domains on  [gi|2124409036|ref|XP_044541468|]
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uncharacterized protein C9374_014759 [Naegleria lovaniensis]

Protein Classification

ZnF_C3H1 and YTH1 domain-containing protein( domain architecture ID 12205583)

ZnF_C3H1 and YTH1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YTH1 super family cl25862
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 62-165 3.91e-29

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


The actual alignment was detected with superfamily member COG5084:

Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 109.96  E-value: 3.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124409036  62 VVCKHWLRGLCKKGDGCEFLHQY--KAGKMPECWFFSEYGECSNL-ECIFLHIKPEDRIKNCPWYEK---GFCKHGPNCR 135
Cdd:COG5084   105 VVCKFFLRGLCKSGFSCEFLHEYdlRSSQGPPCRSFSLKGSCSSGpSCGYSHIDPDSFAGNCDQYSGatyGFCPLGASCK 184

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2124409036 136 LKHIRKIA------CPDYLAGFCAKGPN--------------CKFSHPKF 165
Cdd:COG5084   185 FSHTLKRVsygsspCGNYTPPFSPPGTPsesvsswgygkgtsCSLSHPSL 234
ZnF_C3H1 smart00356
zinc finger;
32-52 3.26e-03

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 34.14  E-value: 3.26e-03
                           10        20
                   ....*....|....*....|.
gi 2124409036   32 VCKFFLKGQCRKGKDCQYKHI 52
Cdd:smart00356   6 LCKFFKRGYCPRGDRCKFAHP 26
 
Name Accession Description Interval E-value
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 62-165 3.91e-29

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 109.96  E-value: 3.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124409036  62 VVCKHWLRGLCKKGDGCEFLHQY--KAGKMPECWFFSEYGECSNL-ECIFLHIKPEDRIKNCPWYEK---GFCKHGPNCR 135
Cdd:COG5084   105 VVCKFFLRGLCKSGFSCEFLHEYdlRSSQGPPCRSFSLKGSCSSGpSCGYSHIDPDSFAGNCDQYSGatyGFCPLGASCK 184

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2124409036 136 LKHIRKIA------CPDYLAGFCAKGPN--------------CKFSHPKF 165
Cdd:COG5084   185 FSHTLKRVsygsspCGNYTPPFSPPGTPsesvsswgygkgtsCSLSHPSL 234
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 26-114 1.17e-04

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 40.14  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124409036  26 MAKDQNVCKFFLKGQCRKGKDCQYKHiqRQTSKEKEVVCKHWLRGLCKKgDGCEFLHQY--KAGKMPECWFFSEYGECSN 103
Cdd:pfam15663   1 MENKGDDCYFFYYSTCTKGDSCPFRH--CEAALGNETVCTLWQEGRCFR-PVCRFRHMEidKNRKEIPCYWENQPGGCQK 77

                          90
                  ....*....|.
gi 2124409036 104 LECIFLHIKPE 114
Cdd:pfam15663  78 PHCAFHHTKPR 88
ZnF_C3H1 smart00356
zinc finger;
58-82 2.13e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 34.53  E-value: 2.13e-03
                           10        20
                   ....*....|....*....|....*
gi 2124409036   58 KEKEVVCKHWLRGLCKKGDGCEFLH 82
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDRCKFAH 25
ZnF_C3H1 smart00356
zinc finger;
32-52 3.26e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 34.14  E-value: 3.26e-03
                           10        20
                   ....*....|....*....|.
gi 2124409036   32 VCKFFLKGQCRKGKDCQYKHI 52
Cdd:smart00356   6 LCKFFKRGYCPRGDRCKFAHP 26
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 33-51 9.74e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 32.77  E-value: 9.74e-03
                          10
                  ....*....|....*....
gi 2124409036  33 CKFFLKGQCRKGKDCQYKH 51
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
 
Name Accession Description Interval E-value
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 62-165 3.91e-29

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 109.96  E-value: 3.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124409036  62 VVCKHWLRGLCKKGDGCEFLHQY--KAGKMPECWFFSEYGECSNL-ECIFLHIKPEDRIKNCPWYEK---GFCKHGPNCR 135
Cdd:COG5084   105 VVCKFFLRGLCKSGFSCEFLHEYdlRSSQGPPCRSFSLKGSCSSGpSCGYSHIDPDSFAGNCDQYSGatyGFCPLGASCK 184

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2124409036 136 LKHIRKIA------CPDYLAGFCAKGPN--------------CKFSHPKF 165
Cdd:COG5084   185 FSHTLKRVsygsspCGNYTPPFSPPGTPsesvsswgygkgtsCSLSHPSL 234
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 26-114 1.17e-04

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 40.14  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124409036  26 MAKDQNVCKFFLKGQCRKGKDCQYKHiqRQTSKEKEVVCKHWLRGLCKKgDGCEFLHQY--KAGKMPECWFFSEYGECSN 103
Cdd:pfam15663   1 MENKGDDCYFFYYSTCTKGDSCPFRH--CEAALGNETVCTLWQEGRCFR-PVCRFRHMEidKNRKEIPCYWENQPGGCQK 77

                          90
                  ....*....|.
gi 2124409036 104 LECIFLHIKPE 114
Cdd:pfam15663  78 PHCAFHHTKPR 88
ZnF_C3H1 smart00356
zinc finger;
58-82 2.13e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 34.53  E-value: 2.13e-03
                           10        20
                   ....*....|....*....|....*
gi 2124409036   58 KEKEVVCKHWLRGLCKKGDGCEFLH 82
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDRCKFAH 25
ZnF_C3H1 smart00356
zinc finger;
32-52 3.26e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 34.14  E-value: 3.26e-03
                           10        20
                   ....*....|....*....|.
gi 2124409036   32 VCKFFLKGQCRKGKDCQYKHI 52
Cdd:smart00356   6 LCKFFKRGYCPRGDRCKFAHP 26
ZnF_C3H1 smart00356
zinc finger;
140-164 4.69e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 33.76  E-value: 4.69e-03
                           10        20
                   ....*....|....*....|....*
gi 2124409036  140 RKIACPDYLAGFCAKGPNCKFSHPK 164
Cdd:smart00356   3 KTELCKFFKRGYCPRGDRCKFAHPL 27
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 33-51 9.74e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 32.77  E-value: 9.74e-03
                          10
                  ....*....|....*....
gi 2124409036  33 CKFFLKGQCRKGKDCQYKH 51
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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