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Conserved domains on  [gi|2125089313|ref|XP_044744074|]
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intraflagellar transport protein 80 homolog, partial [Chrysoperla carnea]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
97-328 1.68e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  97 SLADIILITSADGKFHLLS-RTGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWS-RSGMLRSTLISCDTPIYT 174
Cdd:COG2319    88 PDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDlATGKLLRTLTGHSGAVTS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 175 GAWAPDNQ--AICHSNGRILcVRSLAANTKPIRWKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWD-SVGHPLYVSGYHD 251
Cdd:COG2319   168 VAFSPDGKllASGSDDGTVR-LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDlATGKLLRTLTGHS 246

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2125089313 252 YPITSVAWSPSGDMFTIGGF-NTIRVCD-STGWSQSLEKPQSGSLYQLNWSIDGTQIAAACANGHIlyahvvgKVFDWK 328
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSAdGTVRLWDlATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV-------RLWDLA 318
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
97-328 1.68e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  97 SLADIILITSADGKFHLLS-RTGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWS-RSGMLRSTLISCDTPIYT 174
Cdd:COG2319    88 PDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDlATGKLLRTLTGHSGAVTS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 175 GAWAPDNQ--AICHSNGRILcVRSLAANTKPIRWKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWD-SVGHPLYVSGYHD 251
Cdd:COG2319   168 VAFSPDGKllASGSDDGTVR-LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDlATGKLLRTLTGHS 246

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2125089313 252 YPITSVAWSPSGDMFTIGGF-NTIRVCD-STGWSQSLEKPQSGSLYQLNWSIDGTQIAAACANGHIlyahvvgKVFDWK 328
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSAdGTVRLWDlATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV-------RLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 91-331 6.08e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 6.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  91 HPGGGKSLA-----DIILITSADGKFHLLS-RTGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWS-RSGMLRS 163
Cdd:cd00200     8 HTGGVTCVAfspdgKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDlETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 164 TLISCDTPIYTGAWAPDNQAI--CHSNGRIlCVRSLAANTKPIRWKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWDSV- 240
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILssSSRDKTI-KVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRt 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 241 GHPLYVSGYHDYPITSVAWSPSGDMFTIGGF-NTIRVCD-STGWSQSLEKPQSGSLYQLNWSIDGTQIAAACANGHIlya 318
Cdd:cd00200   167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSdGTIKLWDlSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI--- 243

                         250
                  ....*....|...
gi 2125089313 319 hvvgKVFDWKHFS 331
Cdd:cd00200   244 ----RVWDLRTGE 252
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-238 7.63e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 7.63e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2125089313  206 WKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWD 238
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
97-328 1.68e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  97 SLADIILITSADGKFHLLS-RTGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWS-RSGMLRSTLISCDTPIYT 174
Cdd:COG2319    88 PDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDlATGKLLRTLTGHSGAVTS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 175 GAWAPDNQ--AICHSNGRILcVRSLAANTKPIRWKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWD-SVGHPLYVSGYHD 251
Cdd:COG2319   168 VAFSPDGKllASGSDDGTVR-LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDlATGKLLRTLTGHS 246

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2125089313 252 YPITSVAWSPSGDMFTIGGF-NTIRVCD-STGWSQSLEKPQSGSLYQLNWSIDGTQIAAACANGHIlyahvvgKVFDWK 328
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSAdGTVRLWDlATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV-------RLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
91-315 3.42e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 3.42e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  91 HPGGGKSLA-----DIILITSADGKFHLLS-RTGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWS-RSGMLRS 163
Cdd:COG2319   161 HSGAVTSVAfspdgKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDlATGKLLR 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 164 TLISCDTPIYTGAWAPDNQ--AICHSNGRIlCVRSLAANTKPIRWKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWD-SV 240
Cdd:COG2319   241 TLTGHSGSVRSVAFSPDGRllASGSADGTV-RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlAT 319

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2125089313 241 GHPLYVSGYHDYPITSVAWSPSGDMFTIGGF-NTIRVCDSTGWSQSLE-KPQSGSLYQLNWSIDGTQIAAACANGHI 315
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTlTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
54-315 4.79e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 4.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  54 PSDVTPLDMHWPTRSPGTGSAGGSIGSAGTTGSASVNHPGGGKSLADIILITSADGKFHLLSRTGRLERSVEAHQGACLV 133
Cdd:COG2319     4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 134 GKWSHDGAGFMTAGEDGLLKIWS-RSGMLRSTLISCDTPIYTGAWAPDNQAI-CHSNGRILCVRSLAANTKPIRWKAHEG 211
Cdd:COG2319    84 VAFSPDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLaSGSADGTVRLWDLATGKLLRTLTGHSG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 212 LILKIAWCHTNGLIVSGGEDCRYRVWDSV-GHPLYVSGYHDYPITSVAWSPSGDMFTIGGF-NTIRVCD-STGWSQSLEK 288
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAdGTVRLWDlATGKLLRTLT 243

                         250       260
                  ....*....|....*....|....*..
gi 2125089313 289 PQSGSLYQLNWSIDGTQIAAACANGHI 315
Cdd:COG2319   244 GHSGSVRSVAFSPDGRLLASGSADGTV 270
WD40 COG2319
WD40 repeat [General function prediction only];
91-281 4.93e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 4.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  91 HPGGGKSLA-----DIILITSADGKFHLLS-RTGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWS-RSGMLRS 163
Cdd:COG2319   203 HTGAVRSVAfspdgKLLASGSADGTVRLWDlATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlATGELLR 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 164 TLISCDTPIYTGAWAPDNQAI-CHSNGRILCVRSLAANTKPIRWKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWD-SVG 241
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLaSGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDlATG 362

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2125089313 242 HPLYVSGYHDYPITSVAWSPSGDMFTIGGF-NTIRVCDSTG 281
Cdd:COG2319   363 ELLRTLTGHTGAVTSVAFSPDGRTLASGSAdGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 91-331 6.08e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 6.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  91 HPGGGKSLA-----DIILITSADGKFHLLS-RTGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWS-RSGMLRS 163
Cdd:cd00200     8 HTGGVTCVAfspdgKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDlETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 164 TLISCDTPIYTGAWAPDNQAI--CHSNGRIlCVRSLAANTKPIRWKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWDSV- 240
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILssSSRDKTI-KVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRt 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 241 GHPLYVSGYHDYPITSVAWSPSGDMFTIGGF-NTIRVCD-STGWSQSLEKPQSGSLYQLNWSIDGTQIAAACANGHIlya 318
Cdd:cd00200   167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSdGTIKLWDlSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI--- 243

                         250
                  ....*....|...
gi 2125089313 319 hvvgKVFDWKHFS 331
Cdd:cd00200   244 ----RVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 120-315 5.85e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 5.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 120 LERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWSRSGM-LRSTLISCDTPIYTGAWAPDNQ--AICHSNGRILCVrS 196
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGeLLRTLKGHTGPVRDVAASADGTylASGSSDKTIRLW-D 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 197 LAANTKPIRWKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWD-SVGHPLYVSGYHDYPITSVAWSPSGDMFTIGGFN-TI 274
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDgTI 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2125089313 275 RVCDSTGWS--QSLEKPQsGSLYQLNWSIDGTQIAAACANGHI 315
Cdd:cd00200   160 KLWDLRTGKcvATLTGHT-GEVNSVAFSPDGEKLLSSSSDGTI 201
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-238 7.17e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 7.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  13 HNGGAICVGWI-NSEDILSCGDDHLL----LKTSVLT-----HESSILCklpSDVTPlDMHWPTrspgTGSAGGSI---- 78
Cdd:cd00200    50 HTGPVRDVAASaDGTYLASGSSDKTIrlwdLETGECVrtltgHTSYVSS---VAFSP-DGRILS----SSSRDKTIkvwd 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  79 GSAGTTGSASVNHPGGGKSLA-----DIILITSADGKFHLLS-RTGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLL 152
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAfspdgTFVASSSQDGTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 153 KIWS-RSGMLRSTLISCDTPIYTGAWAPDNQAI--CHSNGRIlCVRSLAANTKPIRWKAHEGLILKIAWCHTNGLIVSGG 229
Cdd:cd00200   202 KLWDlSTGKCLGTLRGHENGVNSVAFSPDGYLLasGSEDGTI-RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                  ....*....
gi 2125089313 230 EDCRYRVWD 238
Cdd:cd00200   281 ADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 91-276 9.36e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 9.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313  91 HPGGGKSLA-----DIILITSADGKFHLLS-RTGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWS-RSGMLRS 163
Cdd:cd00200    92 HTSYVSSVAfspdgRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125089313 164 TLISCDTPIYTGAWAPDNQAICHS--NGRIL--------CVRSLAANTKPIRWkaheglilkIAWCHTNGLIVSGGEDCR 233
Cdd:cd00200   172 TLTGHTGEVNSVAFSPDGEKLLSSssDGTIKlwdlstgkCLGTLRGHENGVNS---------VAFSPDGYLLASGSEDGT 242

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2125089313 234 YRVWDSV-GHPLYVSGYHDYPITSVAWSPSGDMFTIGGF-NTIRV 276
Cdd:cd00200   243 IRVWDLRtGECVQTLSGHTNSVTSLAWSPDGKRLASGSAdGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-238 7.63e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 7.63e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2125089313  206 WKAHEGLILKIAWCHTNGLIVSGGEDCRYRVWD 238
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 117-156 2.23e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.23e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2125089313  117 TGRLERSVEAHQGACLVGKWSHDGAGFMTAGEDGLLKIWS 156
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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