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Conserved domains on  [gi|2131016048|ref|XP_044892255|]
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beta-galactosidase isoform X1 [Felis catus]

Protein Classification

glycoside hydrolase family 35 protein( domain architecture ID 10472897)

glycoside hydrolase family 35 protein similar to Xanthomonas phaseoli beta-galactosidase that catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

CAZY:  GH35
EC:  3.2.1.-
Gene Ontology:  GO:0004565|GO:0005975
SCOP:  4003303

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
41-356 0e+00

Glycosyl hydrolases family 35;


:

Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 518.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048  41 RFLKDGQPFRYISGSIHYFRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPQPGQYQFSGEHDVEYFLKLAHELGLLVI 120
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 121 LRPGPYICAEWDMGGLPAWLLLKESIILRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPIITVQVENEYGSYFtCDYDY 200
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYG-VDKAY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 201 LRFLQRRFRDHLGGDVLLFTTDGAHEKFLQCGALQG--IYATVDFGPDANITAAFQIQRKSEPRGPLVNSEFYTGWLDHW 278
Cdd:pfam01301 160 LRALRKAYKEWGADMALLFTTDGPWGMCLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHW 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131016048 279 GQPHSRVRTEVVASSLHDVLAHGANVNLYMFIGGTNFAYWNGANIPYqPQPTSYDYDAPLSEAGDLTDKYFALRDVIR 356
Cdd:pfam01301 240 GGPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYG-PQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
41-356 0e+00

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 518.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048  41 RFLKDGQPFRYISGSIHYFRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPQPGQYQFSGEHDVEYFLKLAHELGLLVI 120
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 121 LRPGPYICAEWDMGGLPAWLLLKESIILRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPIITVQVENEYGSYFtCDYDY 200
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYG-VDKAY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 201 LRFLQRRFRDHLGGDVLLFTTDGAHEKFLQCGALQG--IYATVDFGPDANITAAFQIQRKSEPRGPLVNSEFYTGWLDHW 278
Cdd:pfam01301 160 LRALRKAYKEWGADMALLFTTDGPWGMCLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHW 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131016048 279 GQPHSRVRTEVVASSLHDVLAHGANVNLYMFIGGTNFAYWNGANIPYqPQPTSYDYDAPLSEAGDLTDKYFALRDVIR 356
Cdd:pfam01301 240 GGPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYG-PQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
47-487 3.11e-57

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 203.23  E-value: 3.11e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048  47 QPFRYISGSIHYFRVPRFYWKDRLLKMKMAGLNAIQT-YVPWNFHEPQPGQYQFSGehdVEYFLKLAHELGLLVILRPGP 125
Cdd:COG1874     7 KPFLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKVILRTPT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 126 YIcaewdmggLPAWLLLKESIILR-----------------SSDPDYLAAVDKWLGVLLPKmkpllYQNGGPIITVQVEN 188
Cdd:COG1874    84 AA--------PPAWLLKKYPEILPvdadgrrrgfgsrrhycPSSPVYREAARRIVRALAER-----YGDHPAVIMWQVDN 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 189 EYGSYFTCDY------------------------------------------------------DYLRFLQRRFRDHL-- 212
Cdd:COG1874   151 EYGSYDYCDAcaaafrdwlrerygtldalneawgtafwsqrytdwdeiepprltpttanpslrlDFRRFSSDQVLEYLra 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 213 --------GGDVLLFTTDGAHEKFLQCGALQgiyATVDFGPDAN---------ITAAFQ--IQRKSEPRGPLVNSEFYTG 273
Cdd:COG1874   231 qrdilreaGPDVPVTTNFMGPFPGLDYWKLA---RDLDVVSWDNypdgsaadpDEIAFAhdLMRGLKGGGPFMVMEQWPG 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 274 WLdHWGQPHSRVRTEVVASSLHDVLAHGAN-VNLYMfiggtnfaywnganipYQPQP--TSYDYDAPLSEAGDLTDKYFA 350
Cdd:COG1874   308 WV-NWGPYNPAKRPGQLRLWSLQALAHGADgVNYFQ----------------WRPSRggTEYDHDAPLDHAGRPTRKFRE 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 351 LRDVIRKFEKVPEgfIPPSTPKfayGKVALqklktVEDALNVLcpAGPIKSLypltfiQVKQYFGFV-----LYRTTLpq 425
Cdd:COG1874   371 VRELGAELARLPE--VPGSRVT---ARVAL-----LFDWESWW--ALEIQSP------PLGQDLGYVdlvraLYRALR-- 430
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2131016048 426 dcsnptplssplngvrdRAYVAVDGVPQGVLERSY----VITLNITGQAGAT-LDLLVENMGRVNYG 487
Cdd:COG1874   431 -----------------RAGVTVDIVPPFADLSGYkllvAPALYLVSDALAErLLAYVENGGRVNYG 480
PLN03059 PLN03059
beta-galactosidase; Provisional
29-354 1.34e-48

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 182.13  E-value: 1.34e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048  29 SQRTFKIDYGHNRFLKDGQPFRYISGSIHYFRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPQPGQYQFSGEHDVEYF 108
Cdd:PLN03059   24 SHGSASVSYDHRAFIINGQRRILISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKF 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 109 LKLAHELGLLVILRPGPYICAEWDMGGLPAWLLLKESIILRSSDPDYLAAVDKWLGVLLPKMKP--LLYQNGGPIITVQV 186
Cdd:PLN03059  104 IKVVQAAGLYVHLRIGPYICAEWNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIVDMMKSekLFEPQGGPIILSQI 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 187 ENEYGSyftCDYDylrflqrrfrdhLGGDVLLFTTDGAhEKFLQCG-ALQGIYATVDFGPDANITAA-------FQIQRK 258
Cdd:PLN03059  184 ENEYGP---VEWE------------IGAPGKAYTKWAA-DMAVKLGtGVPWVMCKQEDAPDPVIDTCngfycenFKPNKD 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 259 SEPRgplVNSEFYTGWLDHWGQPHSRVRTEVVASSLHDVLAHGAN-VNLYMFIGGTNFAYWNGAniPYqpQPTSYDYDAP 337
Cdd:PLN03059  248 YKPK---MWTEAWTGWYTEFGGAVPNRPAEDLAFSVARFIQNGGSfINYYMYHGGTNFGRTAGG--PF--IATSYDYDAP 320
                         330
                  ....*....|....*...
gi 2131016048 338 LSEAGDLTD-KYFALRDV 354
Cdd:PLN03059  321 LDEYGLPREpKWGHLRDL 338
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
41-356 0e+00

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 518.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048  41 RFLKDGQPFRYISGSIHYFRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPQPGQYQFSGEHDVEYFLKLAHELGLLVI 120
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 121 LRPGPYICAEWDMGGLPAWLLLKESIILRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPIITVQVENEYGSYFtCDYDY 200
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYG-VDKAY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 201 LRFLQRRFRDHLGGDVLLFTTDGAHEKFLQCGALQG--IYATVDFGPDANITAAFQIQRKSEPRGPLVNSEFYTGWLDHW 278
Cdd:pfam01301 160 LRALRKAYKEWGADMALLFTTDGPWGMCLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHW 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131016048 279 GQPHSRVRTEVVASSLHDVLAHGANVNLYMFIGGTNFAYWNGANIPYqPQPTSYDYDAPLSEAGDLTDKYFALRDVIR 356
Cdd:pfam01301 240 GGPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYG-PQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
47-487 3.11e-57

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 203.23  E-value: 3.11e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048  47 QPFRYISGSIHYFRVPRFYWKDRLLKMKMAGLNAIQT-YVPWNFHEPQPGQYQFSGehdVEYFLKLAHELGLLVILRPGP 125
Cdd:COG1874     7 KPFLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKVILRTPT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 126 YIcaewdmggLPAWLLLKESIILR-----------------SSDPDYLAAVDKWLGVLLPKmkpllYQNGGPIITVQVEN 188
Cdd:COG1874    84 AA--------PPAWLLKKYPEILPvdadgrrrgfgsrrhycPSSPVYREAARRIVRALAER-----YGDHPAVIMWQVDN 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 189 EYGSYFTCDY------------------------------------------------------DYLRFLQRRFRDHL-- 212
Cdd:COG1874   151 EYGSYDYCDAcaaafrdwlrerygtldalneawgtafwsqrytdwdeiepprltpttanpslrlDFRRFSSDQVLEYLra 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 213 --------GGDVLLFTTDGAHEKFLQCGALQgiyATVDFGPDAN---------ITAAFQ--IQRKSEPRGPLVNSEFYTG 273
Cdd:COG1874   231 qrdilreaGPDVPVTTNFMGPFPGLDYWKLA---RDLDVVSWDNypdgsaadpDEIAFAhdLMRGLKGGGPFMVMEQWPG 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 274 WLdHWGQPHSRVRTEVVASSLHDVLAHGAN-VNLYMfiggtnfaywnganipYQPQP--TSYDYDAPLSEAGDLTDKYFA 350
Cdd:COG1874   308 WV-NWGPYNPAKRPGQLRLWSLQALAHGADgVNYFQ----------------WRPSRggTEYDHDAPLDHAGRPTRKFRE 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 351 LRDVIRKFEKVPEgfIPPSTPKfayGKVALqklktVEDALNVLcpAGPIKSLypltfiQVKQYFGFV-----LYRTTLpq 425
Cdd:COG1874   371 VRELGAELARLPE--VPGSRVT---ARVAL-----LFDWESWW--ALEIQSP------PLGQDLGYVdlvraLYRALR-- 430
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2131016048 426 dcsnptplssplngvrdRAYVAVDGVPQGVLERSY----VITLNITGQAGAT-LDLLVENMGRVNYG 487
Cdd:COG1874   431 -----------------RAGVTVDIVPPFADLSGYkllvAPALYLVSDALAErLLAYVENGGRVNYG 480
PLN03059 PLN03059
beta-galactosidase; Provisional
29-354 1.34e-48

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 182.13  E-value: 1.34e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048  29 SQRTFKIDYGHNRFLKDGQPFRYISGSIHYFRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPQPGQYQFSGEHDVEYF 108
Cdd:PLN03059   24 SHGSASVSYDHRAFIINGQRRILISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKF 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 109 LKLAHELGLLVILRPGPYICAEWDMGGLPAWLLLKESIILRSSDPDYLAAVDKWLGVLLPKMKP--LLYQNGGPIITVQV 186
Cdd:PLN03059  104 IKVVQAAGLYVHLRIGPYICAEWNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIVDMMKSekLFEPQGGPIILSQI 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 187 ENEYGSyftCDYDylrflqrrfrdhLGGDVLLFTTDGAhEKFLQCG-ALQGIYATVDFGPDANITAA-------FQIQRK 258
Cdd:PLN03059  184 ENEYGP---VEWE------------IGAPGKAYTKWAA-DMAVKLGtGVPWVMCKQEDAPDPVIDTCngfycenFKPNKD 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 259 SEPRgplVNSEFYTGWLDHWGQPHSRVRTEVVASSLHDVLAHGAN-VNLYMFIGGTNFAYWNGAniPYqpQPTSYDYDAP 337
Cdd:PLN03059  248 YKPK---MWTEAWTGWYTEFGGAVPNRPAEDLAFSVARFIQNGGSfINYYMYHGGTNFGRTAGG--PF--IATSYDYDAP 320
                         330
                  ....*....|....*...
gi 2131016048 338 LSEAGDLTD-KYFALRDV 354
Cdd:PLN03059  321 LDEYGLPREpKWGHLRDL 338
Glyco_hydro_42 pfam02449
Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase ...
59-212 8.19e-13

Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.


Pssm-ID: 396834  Cd Length: 376  Bit Score: 70.38  E-value: 8.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048  59 FRVPRFYWKDRLLKMKMAGLNAIQ-TYVPWNFHEPQPGQYQFSGEHDVeyfLKLAHELGLLVILRPGpyicaewdMGGLP 137
Cdd:pfam02449   5 EQWPEETWEEDIRLMKEAGVNVVRiGIFAWAKLEPEEGKYDFEWLDEV---IDLLAKAGIKVILATP--------TAAPP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131016048 138 AWLLLKESIILRS-----------------SDPDYLAAVDKWLGVLLPkmkplLYQNGGPIITVQVENEYGSyfTCDYDY 200
Cdd:pfam02449  74 AWLVKKHPEILPVdadgrrrgfgsrhhycpSSPVYREYAARIVEALAE-----RYGDHPALIGWHIDNEYGC--HVSECY 146
                         170
                  ....*....|..
gi 2131016048 201 LRFLQRRFRDHL 212
Cdd:pfam02449 147 CETCERAFRKWL 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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