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Conserved domains on  [gi|2217309943|ref|XP_047291292|]
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glutathione hydrolase 6 isoform X4 [Homo sapiens]

Protein Classification

gamma-glutamyltransferase family protein( domain architecture ID 139768)

gamma-glutamyltransferase family protein exhibits gamma-glutamyltranspeptidase and/or cephalosporin acylase and/or glutathione hydrolase activity, all involving the hydrolytic splitting of a peptide-like C-N bond

CATH:  1.10.246.130
MEROPS:  T3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G_glu_transpept super family cl19223
Gamma-glutamyltranspeptidase;
146-356 4.07e-10

Gamma-glutamyltranspeptidase;


The actual alignment was detected with superfamily member pfam01019:

Pssm-ID: 450276  Cd Length: 499  Bit Score: 61.84  E-value: 4.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 146 GLPAALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTPLARAL-----VARGTEGLCPLLCHaDGTPLGAGARATNP 220
Cdd:pfam01019  82 GVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALaraeeRLRADPGLRKIFLP-TGRVLKAGELLKQP 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 221 QLAAVLRSAALAP-----TSDLAgDALL--------SLLAGDLgvevpsAVPRPTLEPAEQLPVPQGILFTTPSPSAGPE 287
Cdd:pfam01019 161 ALAKTLELIAEEGpdafyRGELA-QQLVadlqanggIITAEDL------ANYRVKIREPLSADYGGYTVYSPPPSSGGIA 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 288 LLA------LLEAALRSGAPI----------------------PDPCPPFLQTAVSPESSA------------------- 320
Cdd:pfam01019 234 LLQilnileGFDLSSLLNSAEylhllieamklayadrtrylgdPDFVPVPVENLLSPEYAKeraklinpnaafpssyape 313

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2217309943 321 ------LAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLLSN 356
Cdd:pfam01019 314 dggtthFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNN 355
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
146-356 4.07e-10

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 61.84  E-value: 4.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 146 GLPAALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTPLARAL-----VARGTEGLCPLLCHaDGTPLGAGARATNP 220
Cdd:pfam01019  82 GVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALaraeeRLRADPGLRKIFLP-TGRVLKAGELLKQP 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 221 QLAAVLRSAALAP-----TSDLAgDALL--------SLLAGDLgvevpsAVPRPTLEPAEQLPVPQGILFTTPSPSAGPE 287
Cdd:pfam01019 161 ALAKTLELIAEEGpdafyRGELA-QQLVadlqanggIITAEDL------ANYRVKIREPLSADYGGYTVYSPPPSSGGIA 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 288 LLA------LLEAALRSGAPI----------------------PDPCPPFLQTAVSPESSA------------------- 320
Cdd:pfam01019 234 LLQilnileGFDLSSLLNSAEylhllieamklayadrtrylgdPDFVPVPVENLLSPEYAKeraklinpnaafpssyape 313

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2217309943 321 ------LAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLLSN 356
Cdd:pfam01019 314 dggtthFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNN 355
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
 142-356 2.63e-04

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 43.53  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 142 APGLGLPAALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTPLARALVARGT-----EGLCPLLChADGTPLGAGAR 216
Cdd:PLN02198  122 ALSVGVPGEVAGLFTAWKQHGKLPWKRLVRPAEKLAAEGFKISKYLYMQMNATRSdiladKGLSDLFV-SNGELKKPGTI 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 217 ATNPQLAAVLRS-AALAPTSDLAGDALLSL------LAGDLGVEVPSAVPRPTLEPAEQLPVPQGILFTTPSPSAGPELL 289
Cdd:PLN02198  201 CHNPKLALTLRLiGEYGPKAFYNGTVGVNLvrdiqkSGGIITLKDLQSYRVKVKEPLSADILGYRVLGMPPPSSGGAAMM 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 290 ALLEAALRSGAP--IPDPC---------------------PPFLQTA------VSPE----------------------- 317
Cdd:PLN02198  281 LILNILAQYGIPsgVSGPLgvhrliealkhafavrmnlgdPDFVDVTkvvsdmLSPKfaqdlkskindnktfdpkhyggr 360

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2217309943 318 --------SSALAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLLSN 356
Cdd:PLN02198  361 wnqiddhgTSHLSIIDSERNAVSMTSTINGYFGALMLSPSTGIVLNN 407
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
146-356 4.07e-10

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 61.84  E-value: 4.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 146 GLPAALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTPLARAL-----VARGTEGLCPLLCHaDGTPLGAGARATNP 220
Cdd:pfam01019  82 GVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALaraeeRLRADPGLRKIFLP-TGRVLKAGELLKQP 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 221 QLAAVLRSAALAP-----TSDLAgDALL--------SLLAGDLgvevpsAVPRPTLEPAEQLPVPQGILFTTPSPSAGPE 287
Cdd:pfam01019 161 ALAKTLELIAEEGpdafyRGELA-QQLVadlqanggIITAEDL------ANYRVKIREPLSADYGGYTVYSPPPSSGGIA 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 288 LLA------LLEAALRSGAPI----------------------PDPCPPFLQTAVSPESSA------------------- 320
Cdd:pfam01019 234 LLQilnileGFDLSSLLNSAEylhllieamklayadrtrylgdPDFVPVPVENLLSPEYAKeraklinpnaafpssyape 313

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2217309943 321 ------LAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLLSN 356
Cdd:pfam01019 314 dggtthFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNN 355
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
 142-356 2.63e-04

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 43.53  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 142 APGLGLPAALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTPLARALVARGT-----EGLCPLLChADGTPLGAGAR 216
Cdd:PLN02198  122 ALSVGVPGEVAGLFTAWKQHGKLPWKRLVRPAEKLAAEGFKISKYLYMQMNATRSdiladKGLSDLFV-SNGELKKPGTI 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 217 ATNPQLAAVLRS-AALAPTSDLAGDALLSL------LAGDLGVEVPSAVPRPTLEPAEQLPVPQGILFTTPSPSAGPELL 289
Cdd:PLN02198  201 CHNPKLALTLRLiGEYGPKAFYNGTVGVNLvrdiqkSGGIITLKDLQSYRVKVKEPLSADILGYRVLGMPPPSSGGAAMM 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309943 290 ALLEAALRSGAP--IPDPC---------------------PPFLQTA------VSPE----------------------- 317
Cdd:PLN02198  281 LILNILAQYGIPsgVSGPLgvhrliealkhafavrmnlgdPDFVDVTkvvsdmLSPKfaqdlkskindnktfdpkhyggr 360

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2217309943 318 --------SSALAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLLSN 356
Cdd:PLN02198  361 wnqiddhgTSHLSIIDSERNAVSMTSTINGYFGALMLSPSTGIVLNN 407
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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