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Conserved domains on  [gi|347970166|ref|XP_313334|]
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AGAP003580-PA [Anopheles gambiae str. PEST]

Protein Classification

YbhB/YbcL family Raf kinase inhibitor-like protein( domain architecture ID 10096268)

YbhB/YbcL family Raf kinase inhibitor-like protein similar to mammalian phosphatidylethanolamine-binding protein 1/2 and Schizosaccharomyces pombe mitochondrial 54S ribosomal protein L35

CATH:  3.90.280.10
SCOP:  4002457

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 28-172 1.57e-45

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


:

Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 147.52  E-value: 1.57e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166  28 KVVYRGKKLVDAGKELSPAEVREEPKVEW--YADPTALYTLIMTDPDSPSRMEPWNREFAHWLVGNVPG-----RHVQNG 100
Cdd:cd00866    4 TVSYGSSGVVTPGNLLTPSETQKAPTVSFssEDPPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGsdtttGLVSKG 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347970166 101 DTLFEYIPVFPRSGVGFHRYIFLVFRQQSWNDYSqAPRASSKNRTPRIRFCTRDFARHYSLGSPVAGNFFIA 172
Cdd:cd00866   84 EVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFP-ESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 28-172 1.57e-45

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 147.52  E-value: 1.57e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166  28 KVVYRGKKLVDAGKELSPAEVREEPKVEW--YADPTALYTLIMTDPDSPSRMEPWNREFAHWLVGNVPG-----RHVQNG 100
Cdd:cd00866    4 TVSYGSSGVVTPGNLLTPSETQKAPTVSFssEDPPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGsdtttGLVSKG 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347970166 101 DTLFEYIPVFPRSGVGFHRYIFLVFRQQSWNDYSqAPRASSKNRTPRIRFCTRDFARHYSLGSPVAGNFFIA 172
Cdd:cd00866   84 EVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFP-ESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 28-173 4.82e-25

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 95.65  E-value: 4.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166  28 KVVYrGKKLVDAGKELSPAEVREEPKVEWYA-DPTALYTLIMTDPDSPSRMEPWNREFAHWLVGNVPGrhvQNGDTLFEY 106
Cdd:PLN00169  29 RVTY-GSREVNNGCELKPSQVVNQPRVDIGGeDLRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPA---TTGATFGQE 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 347970166 107 IPVF--PRSGVGFHRYIFLVFRQQSwndysqapRASSKNRTPRIRFCTRDFARHYSLGSPVAGNFFIAQ 173
Cdd:PLN00169 105 VVCYesPRPTAGIHRFVFVLFRQLG--------RQTVYAPGWRQNFNTRDFAELYNLGSPVAAVYFNCQ 165
PBP pfam01161
Phosphatidylethanolamine-binding protein;
34-127 2.11e-15

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 69.29  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166   34 KKLVDAGKELSPAevreepkVEWYADP--TALYTLIMTDPDSPSRMEpwnREFAHWLVGNVP-------------GRHVQ 98
Cdd:pfam01161   4 VKYTCGGPNTSPP-------LAWSGAPagTKSFALVMIDPDAPKVGG---SGWLHWVVTNIPatvtelpegapagAVQGL 73

                          90       100
                  ....*....|....*....|....*....
gi 347970166   99 NGDTLFEYIPVFPRSGVGFHRYIFLVFRQ 127
Cdd:pfam01161  74 NDFGGAGYGGPCPPAGDGPHRYVFTLYAL 102
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 64-125 3.99e-05

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 41.68  E-value: 3.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166  64 YTLIMTDPDSPSRMEPWnrefaHWLVGNVP------------------GRHVQNGDTLFEYIPVFPRSGVGFHRYIFLVF 125
Cdd:COG1881   41 FALIVEDPDAPTGGGFW-----HWVVYNIPadvtelpegagsadlpagAVQGRNDFGEAGYGGPCPPPGDGPHRYVFTVY 115
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 28-172 1.57e-45

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 147.52  E-value: 1.57e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166  28 KVVYRGKKLVDAGKELSPAEVREEPKVEW--YADPTALYTLIMTDPDSPSRMEPWNREFAHWLVGNVPG-----RHVQNG 100
Cdd:cd00866    4 TVSYGSSGVVTPGNLLTPSETQKAPTVSFssEDPPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGsdtttGLVSKG 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347970166 101 DTLFEYIPVFPRSGVGFHRYIFLVFRQQSWNDYSqAPRASSKNRTPRIRFCTRDFARHYSLGSPVAGNFFIA 172
Cdd:cd00866   84 EVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFP-ESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 28-173 4.82e-25

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 95.65  E-value: 4.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166  28 KVVYrGKKLVDAGKELSPAEVREEPKVEWYA-DPTALYTLIMTDPDSPSRMEPWNREFAHWLVGNVPGrhvQNGDTLFEY 106
Cdd:PLN00169  29 RVTY-GSREVNNGCELKPSQVVNQPRVDIGGeDLRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPA---TTGATFGQE 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 347970166 107 IPVF--PRSGVGFHRYIFLVFRQQSwndysqapRASSKNRTPRIRFCTRDFARHYSLGSPVAGNFFIAQ 173
Cdd:PLN00169 105 VVCYesPRPTAGIHRFVFVLFRQLG--------RQTVYAPGWRQNFNTRDFAELYNLGSPVAAVYFNCQ 165
PBP pfam01161
Phosphatidylethanolamine-binding protein;
34-127 2.11e-15

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 69.29  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166   34 KKLVDAGKELSPAevreepkVEWYADP--TALYTLIMTDPDSPSRMEpwnREFAHWLVGNVP-------------GRHVQ 98
Cdd:pfam01161   4 VKYTCGGPNTSPP-------LAWSGAPagTKSFALVMIDPDAPKVGG---SGWLHWVVTNIPatvtelpegapagAVQGL 73

                          90       100
                  ....*....|....*....|....*....
gi 347970166   99 NGDTLFEYIPVFPRSGVGFHRYIFLVFRQ 127
Cdd:pfam01161  74 NDFGGAGYGGPCPPAGDGPHRYVFTLYAL 102
PEBP cd00457
PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding ...
 40-172 2.41e-12

PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176642  Cd Length: 159  Bit Score: 61.64  E-value: 2.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166  40 GKELSPAEVREE----PKVEW--YADPTALYTLIMTDPDspsrmEPWNREFAHWLVGNVPG--RHVQNGD---------- 101
Cdd:cd00457   11 GSVLPPEYSFEGvgrfPSLSWdgPPPDVKEYVLVMEDPD-----APLGRPIVHGLVYGIPAnkTSLSNDDfvvtdngkgg 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166 102 -----------TLFEYIPVFPRSGVGFHRYIFLVFRQqswndysQAPRASSKNRTPRIRFCTRDFARHYSLGsPVAGNFF 170
Cdd:cd00457   86 lqggfkygknrGGTVYIGPRPPLGHGPHRYFFQVYAL-------DEPLDRSKLGDGRTKFEVARFAEGNVLG-AVGEWVG 157


                 ..
gi 347970166 171 IA 172
Cdd:cd00457  158 QF 159
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 64-125 3.99e-05

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 41.68  E-value: 3.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166  64 YTLIMTDPDSPSRMEPWnrefaHWLVGNVP------------------GRHVQNGDTLFEYIPVFPRSGVGFHRYIFLVF 125
Cdd:COG1881   41 FALIVEDPDAPTGGGFW-----HWVVYNIPadvtelpegagsadlpagAVQGRNDFGEAGYGGPCPPPGDGPHRYVFTVY 115
PEBP_bact_arch cd00865
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; ...
 52-125 2.00e-03

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.


Pssm-ID: 176643  Cd Length: 150  Bit Score: 37.20  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347970166  52 PKVEWYADP--TALYTLIMTDPDSPSRMEPWnrefaHWLVGNVP------------------GRHVQNGDTLFEYIPVFP 111
Cdd:cd00865   28 PPLSWSGVPagTKSLALIVEDPDAPTGGGFV-----HWVVWNIPadttelpegasrgalpagAVQGRNDFGEAGYGGPCP 102

                         90
                 ....*....|....
gi 347970166 112 RSGvGFHRYIFLVF 125
Cdd:cd00865  103 PDG-GPHRYVFTVY 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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