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Conserved domains on  [gi|118100151|ref|XP_415767|]
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ion channel TACAN [Gallus gallus]

Protein Classification

TMEM120 family protein( domain architecture ID 10545183)

TMEM120 (transmembrane protein 120) family protein similar to ion channel TACAN that is involved in sensing mechanical pain, contributing to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMPIT pfam07851
TMPIT-like protein; A number of members of this family are annotated as being transmembrane ...
 8-331 0e+00

TMPIT-like protein; A number of members of this family are annotated as being transmembrane proteins induced by tumour necrosis factor alpha, but no literature was found to support this.


:

Pssm-ID: 462288  Cd Length: 324  Bit Score: 510.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151    8 LREWEELQDGFQRIQDNHRLYKQKLEELTKLQDGISSCITRQKKRLKELSLSLKKCKTHVSPEQRDSVQEIQSLIKERQN 87
Cdd:pfam07851   1 LEEWEELEKEFQQLQETHKEYKQKLEELSSLQTRCKKSIKHQKKRLKELKSSLKRLQRSSIEEDQSLIKELQEEIKERKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151   88 VFFEMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILLIVSFSCRFLLNSRVTDSAFNFLLVWYY 167
Cdd:pfam07851  81 QLFEMEALLPKKNGLYLNLILGNVNVSLLNKDEKFKYKDEYEKFKLILTIIFLLLSVLLLFLLNYRFLDALFQFLLVWYY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151  168 CTLTIRESILINNGSKIKGWWVFHHHISTFLSGVMLTWPDGLMYQMFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALG 247
Cdd:pfam07851 161 CTLTIRESILIVNGSRIKGWWVFHHYISTALSGVLLTWPDGEQYQSFRPQFLFFSFYQSVVQFLQYYYQRGCLYRLRALG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151  248 ERHNMDLTVEGFQSWMWRGLTFLLPFLFFGQFWQLYNAVTLFRMLQHPECKEWQVLMCGLPFFVLFLGNFFTTLRVVHQK 327
Cdd:pfam07851 241 ERHNMDVTVEGFQSWMWRGLTFLLPFLFFGHFFQLYNAYTLFRLARQPECCEWQVFVLGLLFLILFLGNFFTTLQVVPQK 320


                  ....
gi 118100151  328 FQNQ 331
Cdd:pfam07851 321 LKRK 324
 
Name Accession Description Interval E-value
TMPIT pfam07851
TMPIT-like protein; A number of members of this family are annotated as being transmembrane ...
 8-331 0e+00

TMPIT-like protein; A number of members of this family are annotated as being transmembrane proteins induced by tumour necrosis factor alpha, but no literature was found to support this.


Pssm-ID: 462288  Cd Length: 324  Bit Score: 510.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151    8 LREWEELQDGFQRIQDNHRLYKQKLEELTKLQDGISSCITRQKKRLKELSLSLKKCKTHVSPEQRDSVQEIQSLIKERQN 87
Cdd:pfam07851   1 LEEWEELEKEFQQLQETHKEYKQKLEELSSLQTRCKKSIKHQKKRLKELKSSLKRLQRSSIEEDQSLIKELQEEIKERKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151   88 VFFEMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILLIVSFSCRFLLNSRVTDSAFNFLLVWYY 167
Cdd:pfam07851  81 QLFEMEALLPKKNGLYLNLILGNVNVSLLNKDEKFKYKDEYEKFKLILTIIFLLLSVLLLFLLNYRFLDALFQFLLVWYY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151  168 CTLTIRESILINNGSKIKGWWVFHHHISTFLSGVMLTWPDGLMYQMFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALG 247
Cdd:pfam07851 161 CTLTIRESILIVNGSRIKGWWVFHHYISTALSGVLLTWPDGEQYQSFRPQFLFFSFYQSVVQFLQYYYQRGCLYRLRALG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151  248 ERHNMDLTVEGFQSWMWRGLTFLLPFLFFGQFWQLYNAVTLFRMLQHPECKEWQVLMCGLPFFVLFLGNFFTTLRVVHQK 327
Cdd:pfam07851 241 ERHNMDVTVEGFQSWMWRGLTFLLPFLFFGHFFQLYNAYTLFRLARQPECCEWQVFVLGLLFLILFLGNFFTTLQVVPQK 320


                  ....
gi 118100151  328 FQNQ 331
Cdd:pfam07851 321 LKRK 324
 
Name Accession Description Interval E-value
TMPIT pfam07851
TMPIT-like protein; A number of members of this family are annotated as being transmembrane ...
 8-331 0e+00

TMPIT-like protein; A number of members of this family are annotated as being transmembrane proteins induced by tumour necrosis factor alpha, but no literature was found to support this.


Pssm-ID: 462288  Cd Length: 324  Bit Score: 510.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151    8 LREWEELQDGFQRIQDNHRLYKQKLEELTKLQDGISSCITRQKKRLKELSLSLKKCKTHVSPEQRDSVQEIQSLIKERQN 87
Cdd:pfam07851   1 LEEWEELEKEFQQLQETHKEYKQKLEELSSLQTRCKKSIKHQKKRLKELKSSLKRLQRSSIEEDQSLIKELQEEIKERKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151   88 VFFEMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILLIVSFSCRFLLNSRVTDSAFNFLLVWYY 167
Cdd:pfam07851  81 QLFEMEALLPKKNGLYLNLILGNVNVSLLNKDEKFKYKDEYEKFKLILTIIFLLLSVLLLFLLNYRFLDALFQFLLVWYY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151  168 CTLTIRESILINNGSKIKGWWVFHHHISTFLSGVMLTWPDGLMYQMFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALG 247
Cdd:pfam07851 161 CTLTIRESILIVNGSRIKGWWVFHHYISTALSGVLLTWPDGEQYQSFRPQFLFFSFYQSVVQFLQYYYQRGCLYRLRALG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118100151  248 ERHNMDLTVEGFQSWMWRGLTFLLPFLFFGQFWQLYNAVTLFRMLQHPECKEWQVLMCGLPFFVLFLGNFFTTLRVVHQK 327
Cdd:pfam07851 241 ERHNMDVTVEGFQSWMWRGLTFLLPFLFFGHFFQLYNAYTLFRLARQPECCEWQVFVLGLLFLILFLGNFFTTLQVVPQK 320


                  ....
gi 118100151  328 FQNQ 331
Cdd:pfam07851 321 LKRK 324
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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