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Conserved domains on  [gi|50747210|ref|XP_420786|]
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heparan sulfate glucosamine 3-O-sulfotransferase 1 [Gallus gallus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
62-297 4.67e-36

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 130.54  E-value: 4.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210    62 LPQTIIIGVRKGGTRALLEMLSLHPDIAAAE--SEVHFFDWEDHYRnGLQWYInqmpfsyphqitvekTPAYFTSPEVPE 139
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEksEEPHLFNNHNRSP-FLEWYP---------------GDTYFDVAEGPV 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210   140 RVYNMNqSMRLL---------------------LILRDPSERVLSDYTQVFYNHMQKHKPYPSIEQFLIKDGELNvdyka 198
Cdd:pfam00685  65 RLNALP-SPRIIkthlplhllpkslwdpnakiiYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVN----- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210   199 inRSLYYIHMQNWLKYFPLDHIHIVDGDKLIKDPFPEIEKVERFLKLSP-----QINASNFYFNKTKGFYCLRDS----- 268
Cdd:pfam00685 139 --CGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSklpke 216

                         250       260       270
                  ....*....|....*....|....*....|..
gi 50747210   269 ---GRERCLHESKgraHPQVDTRLLEKLHEYF 297
Cdd:pfam00685 217 vspFFRKGLVGDW---KNYFTPEQAEKFDEIY 245
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
62-297 4.67e-36

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 130.54  E-value: 4.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210    62 LPQTIIIGVRKGGTRALLEMLSLHPDIAAAE--SEVHFFDWEDHYRnGLQWYInqmpfsyphqitvekTPAYFTSPEVPE 139
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEksEEPHLFNNHNRSP-FLEWYP---------------GDTYFDVAEGPV 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210   140 RVYNMNqSMRLL---------------------LILRDPSERVLSDYTQVFYNHMQKHKPYPSIEQFLIKDGELNvdyka 198
Cdd:pfam00685  65 RLNALP-SPRIIkthlplhllpkslwdpnakiiYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVN----- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210   199 inRSLYYIHMQNWLKYFPLDHIHIVDGDKLIKDPFPEIEKVERFLKLSP-----QINASNFYFNKTKGFYCLRDS----- 268
Cdd:pfam00685 139 --CGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSklpke 216

                         250       260       270
                  ....*....|....*....|....*....|..
gi 50747210   269 ---GRERCLHESKgraHPQVDTRLLEKLHEYF 297
Cdd:pfam00685 217 vspFFRKGLVGDW---KNYFTPEQAEKFDEIY 245
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
62-297 4.67e-36

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 130.54  E-value: 4.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210    62 LPQTIIIGVRKGGTRALLEMLSLHPDIAAAE--SEVHFFDWEDHYRnGLQWYInqmpfsyphqitvekTPAYFTSPEVPE 139
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEksEEPHLFNNHNRSP-FLEWYP---------------GDTYFDVAEGPV 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210   140 RVYNMNqSMRLL---------------------LILRDPSERVLSDYTQVFYNHMQKHKPYPSIEQFLIKDGELNvdyka 198
Cdd:pfam00685  65 RLNALP-SPRIIkthlplhllpkslwdpnakiiYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVN----- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210   199 inRSLYYIHMQNWLKYFPLDHIHIVDGDKLIKDPFPEIEKVERFLKLSP-----QINASNFYFNKTKGFYCLRDS----- 268
Cdd:pfam00685 139 --CGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSklpke 216

                         250       260       270
                  ....*....|....*....|....*....|..
gi 50747210   269 ---GRERCLHESKgraHPQVDTRLLEKLHEYF 297
Cdd:pfam00685 217 vspFFRKGLVGDW---KNYFTPEQAEKFDEIY 245
Sulfotransfer_3 pfam13469
Sulfotransferase family;
66-245 3.66e-14

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 69.24  E-value: 3.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210    66 IIIGVRKGGTRALLEMLSLHPDIAAAESEVHFF-DWEDHYRNGLQWYINQMPFSYPHQITVEKTPAYFTSPEVPERVY-N 143
Cdd:pfam13469   2 FIVGLPRSGTTLLHRLLAAHPDVRPPEETWFVIpRILALLQAWGKSLEALARVPSYARWLCDKSPSHLFHLDLLLKAFpD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50747210   144 MnqsmRLLLILRDPSERVLSDYTQVFYNHMQKHKpYPSIEQFlikDGELNVDYKAINRSlyyihMQNWLKYFPlDHIHIV 223
Cdd:pfam13469  82 A----KFIHLHRDPVDTVISSYCSLFGFTLSSYS-TAFLRDI---GLALARWSRAYERL-----MAARARVPP-GRFLDV 147

                         170       180
                  ....*....|....*....|..
gi 50747210   224 DGDKLIKDPFPEIEKVERFLKL 245
Cdd:pfam13469 148 RYEDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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