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Conserved domains on  [gi|294658506|ref|XP_460846|]
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DEHA2F11066p [Debaryomyces hansenii CBS767]

Protein Classification

WD repeat WDR12/YTM1 family ribosome biogenesis protein( domain architecture ID 10548159)

WD repeat WDR12/YTM1 family ribosome biogenesis protein is required for maturation of ribosomal RNAs and the formation of the ribosome

CATH:  2.130.10.10
Gene Ontology:  GO:0042254|GO:0005515
PubMed:  10322433|18448671|17353269|18925368|8090199|21468892|29026209|30069656
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-458 4.98e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 148.25  E-value: 4.98e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 133 SQPKILSGSYDGIVRTYNMS-GKVEKQYVGHSGPIRSVKWISP-TRIVSSGNDRQVRLWKtsidsnieddeeIEDGRTLA 210
Cdd:cd00200   20 DGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADgTYLASGSSDKTIRLWD------------LETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 211 ILEGHKAPVVSLAVeYQNNRIL-SAGYDKAIGFWSTNYREMTTIqpleydsnvistsskkrrkmalqdstirrrsplsfL 289
Cdd:cd00200   88 TLTGHTSYVSSVAF-SPDGRILsSSSRDKTIKVWDVETGKCLTT-----------------------------------L 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 290 EGHSQPVEDVIFDFNDaTVGYSVSQDHTIKTWDLVTSRCVDTRTTGYSLLSLLQLPSLNLLVC-GSSARHINLFDPRVSS 368
Cdd:cd00200  132 RGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLsSSSDGTIKLWDLSTGK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 369 TTTEqtnnqkLIGHTNFVVGLSKCPtNDNMFASCSHDGTVKVWDVRSEKSLYTITREQNnaakgqdKVFSVIWDNDIG-I 447
Cdd:cd00200  211 CLGT------LRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN-------SVTSLAWSPDGKrL 276

                        330
                 ....*....|.
gi 294658506 448 ISGGQDKKIQI 458
Cdd:cd00200  277 ASGSADGTIRI 287
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 8-78 4.12e-24

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 94.90  E-value: 4.12e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 294658506    8 IKINFFTneEDESLHTSDAPLYVPVSLKRYGLSEIVNHLLKKDgetDETKPVPFDFLIDGVLLRTSLEDYL 78
Cdd:pfam08154   1 VQVRFVT--KEGELAVPGTPLDVPVSLTRYQLSELVNSLLKNE---ELEKPVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-458 4.98e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 148.25  E-value: 4.98e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 133 SQPKILSGSYDGIVRTYNMS-GKVEKQYVGHSGPIRSVKWISP-TRIVSSGNDRQVRLWKtsidsnieddeeIEDGRTLA 210
Cdd:cd00200   20 DGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADgTYLASGSSDKTIRLWD------------LETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 211 ILEGHKAPVVSLAVeYQNNRIL-SAGYDKAIGFWSTNYREMTTIqpleydsnvistsskkrrkmalqdstirrrsplsfL 289
Cdd:cd00200   88 TLTGHTSYVSSVAF-SPDGRILsSSSRDKTIKVWDVETGKCLTT-----------------------------------L 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 290 EGHSQPVEDVIFDFNDaTVGYSVSQDHTIKTWDLVTSRCVDTRTTGYSLLSLLQLPSLNLLVC-GSSARHINLFDPRVSS 368
Cdd:cd00200  132 RGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLsSSSDGTIKLWDLSTGK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 369 TTTEqtnnqkLIGHTNFVVGLSKCPtNDNMFASCSHDGTVKVWDVRSEKSLYTITREQNnaakgqdKVFSVIWDNDIG-I 447
Cdd:cd00200  211 CLGT------LRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN-------SVTSLAWSPDGKrL 276

                        330
                 ....*....|.
gi 294658506 448 ISGGQDKKIQI 458
Cdd:cd00200  277 ASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
108-458 5.29e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 5.29e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 108 NDDWISSLDTINPLSASVKASNMSISQPKILSGSYDGIVRTYNM-SGKVEKQYVGHSGPIRSVKWiSP--TRIVSSGNDR 184
Cdd:COG2319   64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTGAVRSVAF-SPdgKTLASGSADG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 185 QVRLWktsidsnieddeEIEDGRTLAILEGHKAPVVSLAVEYQNNRILSAGYDKAIGFWS-TNYREMTTIQPLEY----- 258
Cdd:COG2319  143 TVRLW------------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGavrsv 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 259 ----DSNVISTSSkkrrkmalQDSTIR-----RRSPLSFLEGHSQPVEDVIFDFNDATVgYSVSQDHTIKTWDLVTSRCV 329
Cdd:COG2319  211 afspDGKLLASGS--------ADGTVRlwdlaTGKLLRTLTGHSGSVRSVAFSPDGRLL-ASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 330 DTRTTGysllsllqlPSLNLLVC----------GSSARHINLFDprVSSTTTEQTnnqkLIGHTNFVVGLSKCPtNDNMF 399
Cdd:COG2319  282 RTLTGH---------SGGVNSVAfspdgkllasGSDDGTVRLWD--LATGKLLRT----LTGHTGAVRSVAFSP-DGKTL 345

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 294658506 400 ASCSHDGTVKVWDVRSEKSLYTITReqnnaakGQDKVFSVIWDNDiG--IISGGQDKKIQI 458
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTG-------HTGAVTSVAFSPD-GrtLASGSADGTVRL 398
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 8-78 4.12e-24

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 94.90  E-value: 4.12e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 294658506    8 IKINFFTneEDESLHTSDAPLYVPVSLKRYGLSEIVNHLLKKDgetDETKPVPFDFLIDGVLLRTSLEDYL 78
Cdd:pfam08154   1 VQVRFVT--KEGELAVPGTPLDVPVSLTRYQLSELVNSLLKNE---ELEKPVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 377-412 1.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.60e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 294658506   377 QKLIGHTNFVVGLSKCPtNDNMFASCSHDGTVKVWD 412
Cdd:smart00320   6 KTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
377-412 4.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 294658506  377 QKLIGHTNFVVGLSKCPtNDNMFASCSHDGTVKVWD 412
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 378-442 4.76e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 4.76e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 294658506 378 KLIGHTNFVVGLSKCPTNDNMFASCSHDGTVKVWDVRSEKSLYTITREQNNAAKGQDKVFSVI-WD 442
Cdd:PTZ00420  69 KLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEIKDPQCILKGHKKKISIIdWN 134
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-458 4.98e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 148.25  E-value: 4.98e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 133 SQPKILSGSYDGIVRTYNMS-GKVEKQYVGHSGPIRSVKWISP-TRIVSSGNDRQVRLWKtsidsnieddeeIEDGRTLA 210
Cdd:cd00200   20 DGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADgTYLASGSSDKTIRLWD------------LETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 211 ILEGHKAPVVSLAVeYQNNRIL-SAGYDKAIGFWSTNYREMTTIqpleydsnvistsskkrrkmalqdstirrrsplsfL 289
Cdd:cd00200   88 TLTGHTSYVSSVAF-SPDGRILsSSSRDKTIKVWDVETGKCLTT-----------------------------------L 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 290 EGHSQPVEDVIFDFNDaTVGYSVSQDHTIKTWDLVTSRCVDTRTTGYSLLSLLQLPSLNLLVC-GSSARHINLFDPRVSS 368
Cdd:cd00200  132 RGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLsSSSDGTIKLWDLSTGK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 369 TTTEqtnnqkLIGHTNFVVGLSKCPtNDNMFASCSHDGTVKVWDVRSEKSLYTITREQNnaakgqdKVFSVIWDNDIG-I 447
Cdd:cd00200  211 CLGT------LRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN-------SVTSLAWSPDGKrL 276

                        330
                 ....*....|.
gi 294658506 448 ISGGQDKKIQI 458
Cdd:cd00200  277 ASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
108-458 5.29e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 5.29e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 108 NDDWISSLDTINPLSASVKASNMSISQPKILSGSYDGIVRTYNM-SGKVEKQYVGHSGPIRSVKWiSP--TRIVSSGNDR 184
Cdd:COG2319   64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTGAVRSVAF-SPdgKTLASGSADG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 185 QVRLWktsidsnieddeEIEDGRTLAILEGHKAPVVSLAVEYQNNRILSAGYDKAIGFWS-TNYREMTTIQPLEY----- 258
Cdd:COG2319  143 TVRLW------------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGavrsv 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 259 ----DSNVISTSSkkrrkmalQDSTIR-----RRSPLSFLEGHSQPVEDVIFDFNDATVgYSVSQDHTIKTWDLVTSRCV 329
Cdd:COG2319  211 afspDGKLLASGS--------ADGTVRlwdlaTGKLLRTLTGHSGSVRSVAFSPDGRLL-ASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 330 DTRTTGysllsllqlPSLNLLVC----------GSSARHINLFDprVSSTTTEQTnnqkLIGHTNFVVGLSKCPtNDNMF 399
Cdd:COG2319  282 RTLTGH---------SGGVNSVAfspdgkllasGSDDGTVRLWD--LATGKLLRT----LTGHTGAVRSVAFSP-DGKTL 345

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 294658506 400 ASCSHDGTVKVWDVRSEKSLYTITReqnnaakGQDKVFSVIWDNDiG--IISGGQDKKIQI 458
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTG-------HTGAVTSVAFSPD-GrtLASGSADGTVRL 398
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 8-78 4.12e-24

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 94.90  E-value: 4.12e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 294658506    8 IKINFFTneEDESLHTSDAPLYVPVSLKRYGLSEIVNHLLKKDgetDETKPVPFDFLIDGVLLRTSLEDYL 78
Cdd:pfam08154   1 VQVRFVT--KEGELAVPGTPLDVPVSLTRYQLSELVNSLLKNE---ELEKPVPFDFLINGEFLRTSLEEHL 66
WD40 COG2319
WD40 repeat [General function prediction only];
137-458 6.89e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 6.89e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 137 ILSGSYDGIVRTYNMSGKVEKQYVGHSGPIRSVKWIS-PTRIVSSGNDRQVRLWktsidsnieddeEIEDGRTLAILEGH 215
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPdGRLLASASADGTVRLW------------DLATGLLLRTLTGH 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 216 KAPVVSLAVEYQNNRILSAGYDKAIGFWST-NYREMTTIQPLEY---------DSNVISTSSkkrrkmalQDSTIR---- 281
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGavtsvafspDGKLLASGS--------DDGTVRlwdl 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 282 -RRSPLSFLEGHSQPVEDVIFDFNDATVgYSVSQDHTIKTWDLVTSRCVDTRTTGysllsllqlPSLNLLV--------- 351
Cdd:COG2319  192 aTGKLLRTLTGHTGAVRSVAFSPDGKLL-ASGSADGTVRLWDLATGKLLRTLTGH---------SGSVRSVafspdgrll 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 352 -CGSSARHINLFDprVSSTTTEQTnnqkLIGHTNFVVGLSKCPtNDNMFASCSHDGTVKVWDVRSEKSLYTITREqnnaa 430
Cdd:COG2319  262 aSGSADGTVRLWD--LATGELLRT----LTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGH----- 329

                        330       340       350
                 ....*....|....*....|....*....|
gi 294658506 431 kgQDKVFSVIWDNDiG--IISGGQDKKIQI 458
Cdd:COG2319  330 --TGAVRSVAFSPD-GktLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
137-325 5.96e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 5.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 137 ILSGSYDGIVRTYNM-SGKVEKQYVGHSGPIRSVKWiSP--TRIVSSGNDRQVRLWktsidsnieddeEIEDGRTLAILE 213
Cdd:COG2319  261 LASGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAF-SPdgKLLASGSDDGTVRLW------------DLATGKLLRTLT 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 214 GHKAPVVSLAVEYQNNRILSAGYDKAIGFWStnyremttiqpleydsnvistsskkrrkmalqdstIRRRSPLSFLEGHS 293
Cdd:COG2319  328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWD-----------------------------------LATGELLRTLTGHT 372

                        170       180       190
                 ....*....|....*....|....*....|..
gi 294658506 294 QPVEDVIFDFNDATVgYSVSQDHTIKTWDLVT 325
Cdd:COG2319  373 GAVTSVAFSPDGRTL-ASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
160-458 1.70e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 1.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 160 VGHSGPIRSVKWISP-TRIVSSGNDRQVRLWKTsidsnieddeeiEDGRTLAILEGHKAPVVSLAVEYQNNRILSAGYDK 238
Cdd:COG2319   33 LGLAAAVASLAASPDgARLAAGAGDLTLLLLDA------------AAGALLATLLGHTAAVLSVAFSPDGRLLASASADG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 239 AIGFWSTNYREMTTiQPLEYDSNVISTS-SKKRRKMAL--QDSTIR-----RRSPLSFLEGHSQPVEDVIFDFNDATVgY 310
Cdd:COG2319  101 TVRLWDLATGLLLR-TLTGHTGAVRSVAfSPDGKTLASgsADGTVRlwdlaTGKLLRTLTGHSGAVTSVAFSPDGKLL-A 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 311 SVSQDHTIKTWDLVTSRCVDTrttgysllsllqlpslnllvcgssarhinlfdprvssttteqtnnqkLIGHTNFVVGLS 390
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLLRT-----------------------------------------------LTGHTGAVRSVA 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 391 KCPtNDNMFASCSHDGTVKVWDVRSEKSLYTITREQNNaakgqdkVFSVIWDNDiG--IISGGQDKKIQI 458
Cdd:COG2319  212 FSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-------VRSVAFSPD-GrlLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 136-244 2.10e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 2.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294658506 136 KILSGSYDGIVRTYNMS-GKVEKQYVGHSGPIRSVKWISPTRIVSSGN-DRQVRLWKTsidsnieddeeiEDGRTLAILE 213
Cdd:cd00200  191 KLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGYLLASGSeDGTIRVWDL------------RTGECVQTLS 258

                         90       100       110
                 ....*....|....*....|....*....|.
gi 294658506 214 GHKAPVVSLAVEYQNNRILSAGYDKAIGFWS 244
Cdd:cd00200  259 GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 377-412 1.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.60e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 294658506   377 QKLIGHTNFVVGLSKCPtNDNMFASCSHDGTVKVWD 412
Cdd:smart00320   6 KTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
377-412 4.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 294658506  377 QKLIGHTNFVVGLSKCPtNDNMFASCSHDGTVKVWD 412
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 152-190 2.91e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.91e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 294658506   152 SGKVEKQYVGHSGPIRSVKWiSP--TRIVSSGNDRQVRLWK 190
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAF-SPdgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
153-189 3.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 294658506  153 GKVEKQYVGHSGPIRSVKWI-SPTRIVSSGNDRQVRLW 189
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 378-442 4.76e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 4.76e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 294658506 378 KLIGHTNFVVGLSKCPTNDNMFASCSHDGTVKVWDVRSEKSLYTITREQNNAAKGQDKVFSVI-WD 442
Cdd:PTZ00420  69 KLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEIKDPQCILKGHKKKISIIdWN 134
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 205-244 4.97e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.97e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 294658506   205 DGRTLAILEGHKAPVVSLAVEYQNNRILSAGYDKAIGFWS 244
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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