NCBI Conserved Domain Search

Conserved domains on [gi|71425875|ref|XP_813186|]

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beta-ketoacyl synthase family protein, putative [Trypanosoma cruzi]

Protein Classification

beta-ketoacyl-[acyl-carrier-protein] synthase family protein( domain architecture ID 11487926)

beta-ketoacyl-[acyl-carrier-protein] synthase family protein may catalyze the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

PTZ00050

3-oxoacyl-acyl carrier protein synthase; Provisional

23-465

0e+00

3-oxoacyl-acyl carrier protein synthase; Provisional

Pssm-ID: 240245 [Multi-domain] Cd Length: 421 Bit Score: 662.16 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   23 AVTPLGLDVASTWAALCQGRSATRPLKEVPFFFPACIDsdcrltpaaRQKSHEQLLAKMPCQVAAPVLAPSGGPN-FTPT 101
Cdd:PTZ00050   1 VVTPLGVGAESTWEALIAGKSGIRKLTEFPKFLPDCIP---------EQKALENLVAAMPCQIAAEVDQSEFDPSdFAPT 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  102 LRETRATLFAYYAAEEALTHAKLLespakrILASFAKERIGVNIGVGMPSLADVGDVSYSLYADpekvNYSRVNPLFVPK 181
Cdd:PTZ00050  72 KRESRATHFAMAAAREALADAKLD------ILSEKDQERIGVNIGSGIGSLADLTDEMKTLYEK----GHSRVSPYFIPK 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  182 ILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRALCTKYNGMP 261
Cdd:PTZ00050 142 ILGNMAAGLVAIKHKLKGPSGSAVTACATGAHCIGEAFRWIKYGEADIMICGGTEASITPVSFAGFSRMRALCTKYNDDP 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  262 QEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQLCLRSALEDGGNISI 341
Cdd:PTZ00050 222 QRASRPFDKDRAGFVMGEGAGILVLEELEHALRRGAKIYAEIRGYGSSSDAHHITAPHPDGRGARRCMENALKDGANINI 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  342 NDVAYVNAHATGT-IGDDMELHALDKVLGGDGTssrrRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLH 420
Cdd:PTZ00050 302 NDVDYVNAHATSTpIGDKIELKAIKKVFGDSGA----PKLYVSSTKGGLGHLLGAAGAVESIVTILSLYEQIIPPTINLE 377

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 71425875  421 APSAEGLerLQLVRGHAPLPFQG-DAVISTSFGFGGVNTALLFTRV 465
Cdd:PTZ00050 378 NPDAECD--LNLVQGKTAHPLQSiDAVLSTSFGFGGVNTALLFTKY 421

Name

Accession

Description

Interval

E-value

PTZ00050

3-oxoacyl-acyl carrier protein synthase; Provisional

23-465

0e+00

3-oxoacyl-acyl carrier protein synthase; Provisional

Pssm-ID: 240245 [Multi-domain] Cd Length: 421 Bit Score: 662.16 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   23 AVTPLGLDVASTWAALCQGRSATRPLKEVPFFFPACIDsdcrltpaaRQKSHEQLLAKMPCQVAAPVLAPSGGPN-FTPT 101
Cdd:PTZ00050   1 VVTPLGVGAESTWEALIAGKSGIRKLTEFPKFLPDCIP---------EQKALENLVAAMPCQIAAEVDQSEFDPSdFAPT 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  102 LRETRATLFAYYAAEEALTHAKLLespakrILASFAKERIGVNIGVGMPSLADVGDVSYSLYADpekvNYSRVNPLFVPK 181
Cdd:PTZ00050  72 KRESRATHFAMAAAREALADAKLD------ILSEKDQERIGVNIGSGIGSLADLTDEMKTLYEK----GHSRVSPYFIPK 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  182 ILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRALCTKYNGMP 261
Cdd:PTZ00050 142 ILGNMAAGLVAIKHKLKGPSGSAVTACATGAHCIGEAFRWIKYGEADIMICGGTEASITPVSFAGFSRMRALCTKYNDDP 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  262 QEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQLCLRSALEDGGNISI 341
Cdd:PTZ00050 222 QRASRPFDKDRAGFVMGEGAGILVLEELEHALRRGAKIYAEIRGYGSSSDAHHITAPHPDGRGARRCMENALKDGANINI 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  342 NDVAYVNAHATGT-IGDDMELHALDKVLGGDGTssrrRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLH 420
Cdd:PTZ00050 302 NDVDYVNAHATSTpIGDKIELKAIKKVFGDSGA----PKLYVSSTKGGLGHLLGAAGAVESIVTILSLYEQIIPPTINLE 377

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 71425875  421 APSAEGLerLQLVRGHAPLPFQG-DAVISTSFGFGGVNTALLFTRV 465
Cdd:PTZ00050 378 NPDAECD--LNLVQGKTAHPLQSiDAVLSTSFGFGGVNTALLFTKY 421

KAS_I_II

cd00834

Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ...

14-462

1.37e-166

Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.

Pssm-ID: 238430 [Multi-domain] Cd Length: 406 Bit Score: 475.49 E-value: 1.37e-166

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKevpfFFPAcidsdcrltpaarqksheqllAKMPCQVAAPVLAPS 93
Cdd:cd00834   1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGIRPIT----RFDA---------------------SGFPSRIAGEVPDFD 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  94 GGPNFTP--TLRETRATLFAYYAAEEALTHAKLLEspakrilASFAKERIGVNIGVGMPSLADVGDVSYSLYADPekvnY 171
Cdd:cd00834  56 PEDYLDRkeLRRMDRFAQFALAAAEEALADAGLDP-------EELDPERIGVVIGSGIGGLATIEEAYRALLEKG----P 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 172 SRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMR 251
Cdd:cd00834 125 RRVSPFFVPMALPNMAAGQVAIRLGLRGPNYTVSTACASGAHAIGDAARLIRLGRADVVIAGGAEALITPLTLAGFAALR 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 252 ALCTKYNgMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQLCLRS 331
Cdd:cd00834 205 ALSTRND-DPEKASRPFDKDRDGFVLGEGAGVLVLESLEHAKARGAKIYAEILGYGASSDAYHITAPDPDGEGAARAMRA 283

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 332 ALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGtssrrRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYH 410
Cdd:cd00834 284 ALADAG-LSPEDIDYINAHGTSTpLNDAAESKAIKRVFGEHA-----KKVPVSSTKSMTGHLLGAAGAVEAIATLLALRD 357

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 71425875 411 QQAPPNINLHAPSAEglERLQLVRgHAPLPFQGDAVISTSFGFGGVNTALLF 462
Cdd:cd00834 358 GVLPPTINLEEPDPE--CDLDYVP-NEAREAPIRYALSNSFGFGGHNASLVF 406

FabB

COG0304

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ...

14-465

1.23e-164

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis

Pssm-ID: 440073 [Multi-domain] Cd Length: 409 Bit Score: 470.35 E-value: 1.23e-164

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPlkeVPFFFPAcidsdcrltpaarqksheqllaKMPCQVAAPVlaps 93
Cdd:COG0304   1 RRVVITGLGAVSPLGNGVEEFWEALLAGRSGIRP---ITRFDAS----------------------GLPVRIAGEV---- 51

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  94 ggPNFTPTL--------RETRATLFAYYAAEEALTHAKLLESPakrilasFAKERIGVNIGVGMPSLADVGDVSYSLYAD 165
Cdd:COG0304  52 --KDFDPEEyldrkelrRMDRFTQYALAAAREALADAGLDLDE-------VDPDRTGVIIGSGIGGLDTLEEAYRALLEK 122

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 166 pekvNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIA 245
Cdd:COG0304 123 ----GPRRVSPFFVPMMMPNMAAGHVSIRFGLKGPNYTVSTACASGAHAIGEAYRLIRRGRADVMIAGGAEAAITPLGLA 198

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 246 GFSRMRALCTKyNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGA 325
Cdd:COG0304 199 GFDALGALSTR-NDDPEKASRPFDKDRDGFVLGEGAGVLVLEELEHAKARGAKIYAEVVGYGASSDAYHITAPAPDGEGA 277

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 326 QLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGTSsrrrpVYVSSVKGGLGHLLGAAGSVEAIVA 404
Cdd:COG0304 278 ARAMRAALKDAG-LSPEDIDYINAHGTSTpLGDAAETKAIKRVFGDHAYK-----VPVSSTKSMTGHLLGAAGAIEAIAS 351

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71425875 405 IMSLYHQQAPPNINLHAPSAEglERLQLVRGHApLPFQGDAVISTSFGFGGVNTALLFTRV 465
Cdd:COG0304 352 VLALRDGVIPPTINLENPDPE--CDLDYVPNEA-REAKIDYALSNSFGFGGHNASLVFKRY 409

fabF

TIGR03150

beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 ...

14-462

4.32e-147

beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis]

Pssm-ID: 274452 [Multi-domain] Cd Length: 407 Bit Score: 425.75 E-value: 4.32e-147

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKEvpffFPAcidsdcrltpaarqksheqllAKMPCQVAAPVlaps 93
Cdd:TIGR03150   1 RRVVVTGLGAVTPLGNGVEEFWENLLAGKSGIGPITR----FDA---------------------SDLPVKIAGEV---- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    94 ggPNFTPTL--------RETRATLFAYYAAEEALTHAKLLESPAKRilasfakERIGVNIGVGMPSLADVGDVSYSLYad 165
Cdd:TIGR03150  52 --KDFDPEDyidkkearRMDRFIQYALAAAKEAVEDSGLDIEEEDA-------ERVGVIIGSGIGGLETIEEQHIVLL-- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   166 pEKvNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIA 245
Cdd:TIGR03150 121 -EK-GPRRVSPFFIPMSIINMAAGQISIRYGAKGPNHAVVTACATGTHAIGDAFRLIQRGDADVMIAGGAEAAITPLGIA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   246 GFSRMRALCTkYNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGA 325
Cdd:TIGR03150 199 GFAAMKALST-RNDDPEKASRPFDKDRDGFVMGEGAGVLVLEELEHAKARGAKIYAEIVGYGMSGDAYHITAPAPEGEGA 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   326 QLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGgdgtsSRRRPVYVSSVKGGLGHLLGAAGSVEAIVA 404
Cdd:TIGR03150 278 ARAMRAALKDAG-INPEDVDYINAHGTSTpLGDKAETKAIKKVFG-----DHAYKLAVSSTKSMTGHLLGAAGAIEAIFT 351

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 71425875   405 IMSLYHQQAPPNINLHAPSAEGleRLQLVRgHAPLPFQGDAVISTSFGFGGVNTALLF 462
Cdd:TIGR03150 352 VLAIRDGIVPPTINLDNPDPEC--DLDYVP-NEAREAKIDYALSNSFGFGGTNASLVF 406

ketoacyl-synt

pfam00109

Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar ...

14-292

4.26e-40

Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.

Pssm-ID: 425468 [Multi-domain] Cd Length: 251 Bit Score: 144.70 E-value: 4.26e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKevpfffpacidsDCRLTPAARQKSHEQLLAKMPCQVAAPVlaps 93
Cdd:pfam00109   1 EPVAIVGMGCRFPGGNDPEEFWENLLEGRDGISEIP------------ADRWDPDKLYDPPSRIAGKIYTKWGGLD---- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    94 GGPNFTPTL-----RETRAT----LFAYYAAEEALTHAKLLEspakrilASFAKERIGVNIGVGMPSLADvgdvsysLYA 164
Cdd:pfam00109  65 DIFDFDPLFfgispREAERMdpqqRLLLEAAWEALEDAGITP-------DSLDGSRTGVFIGSGIGDYAA-------LLL 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   165 DPEKVNYSRVNPLFVPKIlGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSI 244
Cdd:pfam00109 131 LDEDGGPRRGSPFAVGTM-PSVIAGRISYFLGLRGPSVTVDTACSSSLVAIHAAVQSIRSGEADVALAGGVNLLLTPLGF 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 71425875   245 AGFSRMRALCTkyNGmPQEASRPFDKdrgGFVMGEGSGIIVLEHLEHA 292
Cdd:pfam00109 210 AGFSAAGMLSP--DG-PCKAFDPFAD---GFVRGEGVGAVVLKRLSDA 251

PKS_KS

smart00825

Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the ...

207-461

2.87e-23

Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the thiolase family and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.

Pssm-ID: 214836 [Multi-domain] Cd Length: 298 Bit Score: 99.33 E-value: 2.87e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    207 ACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRALCtkyngmPQEASRPFDKDRGGFVMGEGSGIIVL 286
Cdd:smart00825  96 ACSSSLVALHLACQSLRSGECDMALAGGVNLILSPDTFVGLSRAGMLS------PDGRCKTFDASADGYVRGEGVGVVVL 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    287 EHLEHAMQRGAQIFAELRGFGISSDAHD--LAAPHPEgrgAQLclrsaledggnisindvayvnahatgtigddmelhal 364
Cdd:smart00825 170 KRLSDALRDGDPILAVIRGSAVNQDGRSngITAPSGP---AQL------------------------------------- 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    365 dkvlggdgtssrrrpvYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLHAPS-----AEGleRLQLVRGHAPL 439
Cdd:smart00825 210 ----------------LIGSVKSNIGHLEAAAGVAGLIKVVLALKHGVIPPTLHFETPNphidlEES--PLRVPTELTPW 271

                          250       260
                   ....*....|....*....|....*
gi 71425875    440 PFQGD---AVIStSFGFGGVNTALL 461
Cdd:smart00825 272 PPPGRprrAGVS-SFGFGGTNAHVI 295

Name

Accession

Description

Interval

E-value

PTZ00050

3-oxoacyl-acyl carrier protein synthase; Provisional

23-465

0e+00

3-oxoacyl-acyl carrier protein synthase; Provisional

Pssm-ID: 240245 [Multi-domain] Cd Length: 421 Bit Score: 662.16 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   23 AVTPLGLDVASTWAALCQGRSATRPLKEVPFFFPACIDsdcrltpaaRQKSHEQLLAKMPCQVAAPVLAPSGGPN-FTPT 101
Cdd:PTZ00050   1 VVTPLGVGAESTWEALIAGKSGIRKLTEFPKFLPDCIP---------EQKALENLVAAMPCQIAAEVDQSEFDPSdFAPT 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  102 LRETRATLFAYYAAEEALTHAKLLespakrILASFAKERIGVNIGVGMPSLADVGDVSYSLYADpekvNYSRVNPLFVPK 181
Cdd:PTZ00050  72 KRESRATHFAMAAAREALADAKLD------ILSEKDQERIGVNIGSGIGSLADLTDEMKTLYEK----GHSRVSPYFIPK 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  182 ILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRALCTKYNGMP 261
Cdd:PTZ00050 142 ILGNMAAGLVAIKHKLKGPSGSAVTACATGAHCIGEAFRWIKYGEADIMICGGTEASITPVSFAGFSRMRALCTKYNDDP 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  262 QEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQLCLRSALEDGGNISI 341
Cdd:PTZ00050 222 QRASRPFDKDRAGFVMGEGAGILVLEELEHALRRGAKIYAEIRGYGSSSDAHHITAPHPDGRGARRCMENALKDGANINI 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  342 NDVAYVNAHATGT-IGDDMELHALDKVLGGDGTssrrRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLH 420
Cdd:PTZ00050 302 NDVDYVNAHATSTpIGDKIELKAIKKVFGDSGA----PKLYVSSTKGGLGHLLGAAGAVESIVTILSLYEQIIPPTINLE 377

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 71425875  421 APSAEGLerLQLVRGHAPLPFQG-DAVISTSFGFGGVNTALLFTRV 465
Cdd:PTZ00050 378 NPDAECD--LNLVQGKTAHPLQSiDAVLSTSFGFGGVNTALLFTKY 421

KAS_I_II

cd00834

Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ...

14-462

1.37e-166

Pssm-ID: 238430 [Multi-domain] Cd Length: 406 Bit Score: 475.49 E-value: 1.37e-166

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKevpfFFPAcidsdcrltpaarqksheqllAKMPCQVAAPVLAPS 93
Cdd:cd00834   1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGIRPIT----RFDA---------------------SGFPSRIAGEVPDFD 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  94 GGPNFTP--TLRETRATLFAYYAAEEALTHAKLLEspakrilASFAKERIGVNIGVGMPSLADVGDVSYSLYADPekvnY 171
Cdd:cd00834  56 PEDYLDRkeLRRMDRFAQFALAAAEEALADAGLDP-------EELDPERIGVVIGSGIGGLATIEEAYRALLEKG----P 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 172 SRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMR 251
Cdd:cd00834 125 RRVSPFFVPMALPNMAAGQVAIRLGLRGPNYTVSTACASGAHAIGDAARLIRLGRADVVIAGGAEALITPLTLAGFAALR 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 252 ALCTKYNgMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQLCLRS 331
Cdd:cd00834 205 ALSTRND-DPEKASRPFDKDRDGFVLGEGAGVLVLESLEHAKARGAKIYAEILGYGASSDAYHITAPDPDGEGAARAMRA 283

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 332 ALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGtssrrRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYH 410
Cdd:cd00834 284 ALADAG-LSPEDIDYINAHGTSTpLNDAAESKAIKRVFGEHA-----KKVPVSSTKSMTGHLLGAAGAVEAIATLLALRD 357

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 71425875 411 QQAPPNINLHAPSAEglERLQLVRgHAPLPFQGDAVISTSFGFGGVNTALLF 462
Cdd:cd00834 358 GVLPPTINLEEPDPE--CDLDYVP-NEAREAPIRYALSNSFGFGGHNASLVF 406

FabB

COG0304

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ...

14-465

1.23e-164

Pssm-ID: 440073 [Multi-domain] Cd Length: 409 Bit Score: 470.35 E-value: 1.23e-164

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPlkeVPFFFPAcidsdcrltpaarqksheqllaKMPCQVAAPVlaps 93
Cdd:COG0304   1 RRVVITGLGAVSPLGNGVEEFWEALLAGRSGIRP---ITRFDAS----------------------GLPVRIAGEV---- 51

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  94 ggPNFTPTL--------RETRATLFAYYAAEEALTHAKLLESPakrilasFAKERIGVNIGVGMPSLADVGDVSYSLYAD 165
Cdd:COG0304  52 --KDFDPEEyldrkelrRMDRFTQYALAAAREALADAGLDLDE-------VDPDRTGVIIGSGIGGLDTLEEAYRALLEK 122

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 166 pekvNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIA 245
Cdd:COG0304 123 ----GPRRVSPFFVPMMMPNMAAGHVSIRFGLKGPNYTVSTACASGAHAIGEAYRLIRRGRADVMIAGGAEAAITPLGLA 198

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 246 GFSRMRALCTKyNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGA 325
Cdd:COG0304 199 GFDALGALSTR-NDDPEKASRPFDKDRDGFVLGEGAGVLVLEELEHAKARGAKIYAEVVGYGASSDAYHITAPAPDGEGA 277

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 326 QLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGTSsrrrpVYVSSVKGGLGHLLGAAGSVEAIVA 404
Cdd:COG0304 278 ARAMRAALKDAG-LSPEDIDYINAHGTSTpLGDAAETKAIKRVFGDHAYK-----VPVSSTKSMTGHLLGAAGAIEAIAS 351

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71425875 405 IMSLYHQQAPPNINLHAPSAEglERLQLVRGHApLPFQGDAVISTSFGFGGVNTALLFTRV 465
Cdd:COG0304 352 VLALRDGVIPPTINLENPDPE--CDLDYVPNEA-REAKIDYALSNSFGFGGHNASLVFKRY 409

fabF

TIGR03150

beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 ...

14-462

4.32e-147

Pssm-ID: 274452 [Multi-domain] Cd Length: 407 Bit Score: 425.75 E-value: 4.32e-147

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKEvpffFPAcidsdcrltpaarqksheqllAKMPCQVAAPVlaps 93
Cdd:TIGR03150   1 RRVVVTGLGAVTPLGNGVEEFWENLLAGKSGIGPITR----FDA---------------------SDLPVKIAGEV---- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    94 ggPNFTPTL--------RETRATLFAYYAAEEALTHAKLLESPAKRilasfakERIGVNIGVGMPSLADVGDVSYSLYad 165
Cdd:TIGR03150  52 --KDFDPEDyidkkearRMDRFIQYALAAAKEAVEDSGLDIEEEDA-------ERVGVIIGSGIGGLETIEEQHIVLL-- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   166 pEKvNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIA 245
Cdd:TIGR03150 121 -EK-GPRRVSPFFIPMSIINMAAGQISIRYGAKGPNHAVVTACATGTHAIGDAFRLIQRGDADVMIAGGAEAAITPLGIA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   246 GFSRMRALCTkYNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGA 325
Cdd:TIGR03150 199 GFAAMKALST-RNDDPEKASRPFDKDRDGFVMGEGAGVLVLEELEHAKARGAKIYAEIVGYGMSGDAYHITAPAPEGEGA 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   326 QLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGgdgtsSRRRPVYVSSVKGGLGHLLGAAGSVEAIVA 404
Cdd:TIGR03150 278 ARAMRAALKDAG-INPEDVDYINAHGTSTpLGDKAETKAIKKVFG-----DHAYKLAVSSTKSMTGHLLGAAGAIEAIFT 351

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 71425875   405 IMSLYHQQAPPNINLHAPSAEGleRLQLVRgHAPLPFQGDAVISTSFGFGGVNTALLF 462
Cdd:TIGR03150 352 VLAIRDGIVPPTINLDNPDPEC--DLDYVP-NEAREAKIDYALSNSFGFGGTNASLVF 406

PRK07314

beta-ketoacyl-ACP synthase II;

13-466

2.79e-145

beta-ketoacyl-ACP synthase II;

Pssm-ID: 235987 [Multi-domain] Cd Length: 411 Bit Score: 421.50 E-value: 2.79e-145

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   13 RRRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKEvpfFFPAcidsdcrltpaarqksheqllaKMPCQVAAPVlap 92
Cdd:PRK07314   1 KRRVVVTGLGAVSPLGNDVESTWKNLLAGKSGIGPITH---FDTS----------------------DLAVKIAGEV--- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   93 sggPNFTPTL----RETRA----TLFAYYAAEEALTHAKLLESPAKRilasfakERIGVNIGVGMPSLADVGDVSYSLYa 164
Cdd:PRK07314  53 ---KDFNPDDymsrKEARRmdrfIQYGIAAAKQAVEDAGLEITEENA-------DRIGVIIGSGIGGLETIEEQHITLL- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  165 dpEKvNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSI 244
Cdd:PRK07314 122 --EK-GPRRVSPFFVPMAIINMAAGHVSIRYGAKGPNHSIVTACATGAHAIGDAARLIAYGDADVMVAGGAEAAITPLGI 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  245 AGFSRMRALCTKyNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRG 324
Cdd:PRK07314 199 AGFAAARALSTR-NDDPERASRPFDKDRDGFVMGEGAGILVLEELEHAKARGAKIYAEVVGYGMTGDAYHMTAPAPDGEG 277

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  325 AQLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGTSsrrrpVYVSSVKGGLGHLLGAAGSVEAIV 403
Cdd:PRK07314 278 AARAMKLALKDAG-INPEDIDYINAHGTSTpAGDKAETQAIKRVFGEHAYK-----VAVSSTKSMTGHLLGAAGAVEAIF 351

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71425875  404 AIMSLYHQQAPPNINLHAPSAEGleRLQLVrGHAPLPFQGDAVISTSFGFGGVNTALLFTRVE 466
Cdd:PRK07314 352 SVLAIRDQVIPPTINLDNPDEEC--DLDYV-PNEARERKIDYALSNSFGFGGTNASLVFKRYE 411

PLN02836

3-oxoacyl-[acyl-carrier-protein] synthase

9-465

1.46e-140

3-oxoacyl-[acyl-carrier-protein] synthase

Pssm-ID: 215449 [Multi-domain] Cd Length: 437 Bit Score: 410.34 E-value: 1.46e-140

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    9 PPFIRRRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKEvpfffpacidSDCRLtPAARQKSHEQLLAKMPCQVAAP 88
Cdd:PLN02836   1 PPLPTRRVVVTGLGLVTPLGCGVETTWRRLIAGECGVRALTQ----------DDLKM-KSEDEETQLYTLDQLPSRVAAL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   89 VLAPSGGPNFTPTL-----RETRATLFAYYAAEEALTHAKLLESPAKRilasfaKERIGVNIGVGMPSLADVGDVSySLY 163
Cdd:PLN02836  70 VPRGTGPGDFDEELwlnsrSSSRFIGYALCAADEALSDARWLPSEDEA------KERTGVSIGGGIGSITDILEAA-QLI 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  164 ADPEKvnySRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVS 243
Cdd:PLN02836 143 CEKRL---RRLSPFFVPRILINMAAGHVSIRYGFQGPNHAAVTACATGAHSIGDAFRMIQFGDADVMVAGGTESSIDALS 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  244 IAGFSRMRALCTKYNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGR 323
Cdd:PLN02836 220 IAGFSRSRALSTKFNSCPTEASRPFDCDRDGFVIGEGAGVLVLEELEHAKRRGAKIYAEVRGYGMSGDAHHITQPHEDGR 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  324 GAQLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGTSSRrrpVYVSSVKGGLGHLLGAAGSVEAI 402
Cdd:PLN02836 300 GAVLAMTRALQQSG-LHPNQVDYVNAHATSTpLGDAVEARAIKTVFSEHATSGG---LAFSSTKGATGHLLGAAGAVEAI 375

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71425875  403 VAIMSLYHQQAPPNINLHAPSAEGLERLQLVRGHAPLPFQgdAVISTSFGFGGVNTALLFTRV 465
Cdd:PLN02836 376 FSVLAIHHGIAPPTLNLERPDPIFDDGFVPLTASKAMLIR--AALSNSFGFGGTNASLLFTSP 436

PRK06333

beta-ketoacyl-ACP synthase;

13-464

7.00e-133

beta-ketoacyl-ACP synthase;

Pssm-ID: 235781 [Multi-domain] Cd Length: 424 Bit Score: 390.13 E-value: 7.00e-133

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   13 RRRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKEvpffFPAcidsdcrltpaarqkshEQLLAKMPCQVaaPVLAP 92
Cdd:PRK06333   3 KKRIVVTGMGAVSPLGCGVETFWQRLLAGQSGIRTLTD----FPV-----------------GDLATKIGGQV--PDLAE 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   93 SGGPNFTPTL--------RETRATLFAYYAAEEALTHAKLLESPAKrilasfAKERIGVNIGVGM---PSLADVGDVSys 161
Cdd:PRK06333  60 DAEAGFDPDRyldpkdqrKMDRFILFAMAAAKEALAQAGWDPDTLE------DRERTATIIGSGVggfPAIAEAVRTL-- 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  162 lyadpEKVNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITP 241
Cdd:PRK06333 132 -----DSRGPRRLSPFTIPSFLTNMAAGHVSIRYGFKGPLGAPVTACAAGVQAIGDAARLIRSGEADVAVCGGTEAAIDR 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  242 VSIAGFSRMRALCTKYNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPE 321
Cdd:PRK06333 207 VSLAGFAAARALSTRFNDAPEQASRPFDRDRDGFVMGEGAGILVIETLEHALARGAPPLAELVGYGTSADAYHMTAGPED 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  322 GRGAQLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGTssrrrpVYVSSVKGGLGHLLGAAGSVE 400
Cdd:PRK06333 287 GEGARRAMLIALRQAG-IPPEEVQHLNAHATSTpVGDLGEVAAIKKVFGHVSG------LAVSSTKSATGHLLGAAGGVE 359

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71425875  401 AIVAIMSLYHQQAPPNINLHAPSAEGlERLQLVRGHApLPFQGDAVISTSFGFGGVNTALLFTR 464
Cdd:PRK06333 360 AIFTILALRDQIAPPTLNLENPDPAA-EGLDVVANKA-RPMDMDYALSNGFGFGGVNASILFRR 421

PRK08439

3-oxoacyl-(acyl carrier protein) synthase II; Reviewed

14-465

9.15e-94

3-oxoacyl-(acyl carrier protein) synthase II; Reviewed

Pssm-ID: 236265 [Multi-domain] Cd Length: 406 Bit Score: 289.71 E-value: 9.15e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSAtrpLKEVPFFFPAcidsdcrltpaarqksheqllaKMPCQVAAPVlaps 93
Cdd:PRK08439   2 KRVVVTGIGMINSLGLNKESSFKAICNGECG---IKKITLFDAS----------------------DFPVQIAGEI---- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   94 ggPNFTPTL--------RETRATLFAYYAAEEALTHAKLLESpakrilaSFAKERIGVNIGVGMPSLADVGDVSYSLyad 165
Cdd:PRK08439  53 --TDFDPTEvmdpkevkKADRFIQLGLKAAREAMKDAGFLPE-------ELDAERFGVSSASGIGGLPNIEKNSIIC--- 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  166 pEKVNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIA 245
Cdd:PRK08439 121 -FEKGPRKISPFFIPSALVNMLGGFISIEHGLKGPNLSSVTACAAGTHAIIEAVKTIMLGGADKMLVVGAESAICPVGIG 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  246 GFSRMRALCTKyNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEgrGA 325
Cdd:PRK08439 200 GFAAMKALSTR-NDDPKKASRPFDKDRDGFVMGEGAGALVLEEYESAKKRGAKIYAEIIGFGESGDANHITSPAPE--GP 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  326 QLCLRSALEDGGNISINdvaYVNAHATGT-IGDDMELHALDKVLGGDGTSSRrrpvyVSSVKGGLGHLLGAAGSVEAIVA 404
Cdd:PRK08439 277 LRAMKAALEMAGNPKID---YINAHGTSTpYNDKNETAALKELFGSKEKVPP-----VSSTKGQIGHCLGAAGAIEAVIS 348

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71425875  405 IMSLYHQQAPPNINLHAPSAE-GLERLQLVRGHAPLpfqgDAVISTSFGFGGVNTALLFTRV 465
Cdd:PRK08439 349 IMAMRDGILPPTINQETPDPEcDLDYIPNVARKAEL----NVVMSNSFGFGGTNGVVIFKKV 406

PLN02787

3-oxoacyl-[acyl-carrier-protein] synthase II

9-462

3.74e-87

3-oxoacyl-[acyl-carrier-protein] synthase II

Pssm-ID: 215421 [Multi-domain] Cd Length: 540 Bit Score: 276.86 E-value: 3.74e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    9 PPFIRRRVVVTGLGAVTPLGLDVASTWAALCQGRSAtrpLKEVPFFfpacidsDCrltpaarqksheqllAKMPCQVAAP 88
Cdd:PLN02787 124 PLTKQRRVVVTGMGVVSPLGHDPDVFYNNLLEGVSG---ISEIERF-------DC---------------SQFPTRIAGE 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   89 VLAPSGGPNFTPTL--RETRATLFAYYAAEEALTHAKLLESpakrILASFAKERIGVNIGVGMPSLADVGDVSYSLyadp 166
Cdd:PLN02787 179 IKSFSTDGWVAPKLskRMDKFMLYLLTAGKKALADGGITED----VMKELDKTKCGVLIGSAMGGMKVFNDAIEAL---- 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  167 eKVNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAG 246
Cdd:PLN02787 251 -RISYRKMNPFCVPFATTNMGSAMLAMDLGWMGPNYSISTACATSNFCILNAANHIIRGEADVMLCGGSDAAIIPIGLGG 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  247 FSRMRALcTKYNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQ 326
Cdd:PLN02787 330 FVACRAL-SQRNDDPTKASRPWDMNRDGFVMGEGAGVLLLEELEHAKKRGANIYAEFLGGSFTCDAYHMTEPHPEGAGVI 408

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  327 LCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGTssrrrpVYVSSVKGGLGHLLGAAGSVEAIVAI 405
Cdd:PLN02787 409 LCIEKALAQSG-VSKEDVNYINAHATSTkAGDLKEYQALMRCFGQNPE------LRVNSTKSMIGHLLGAAGAVEAIATV 481

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 71425875  406 MSLYHQQAPPNINLHAPsaEGLERLQLVRGHAPLPFQGDAVISTSFGFGGVNTALLF 462
Cdd:PLN02787 482 QAIRTGWVHPNINLENP--ESGVDTKVLVGPKKERLDIKVALSNSFGFGGHNSSILF 536

PRK08722

beta-ketoacyl-ACP synthase II;

13-465

2.87e-85

beta-ketoacyl-ACP synthase II;

Pssm-ID: 181539 [Multi-domain] Cd Length: 414 Bit Score: 268.02 E-value: 2.87e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   13 RRRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKEvpffFPACIDSdCRLTPAARQKSHEQLLAKMPCQvaapvlap 92
Cdd:PRK08722   3 KRRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIEH----FDTTNFS-TRFAGLVKDFNCEEYMSKKDAR-------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   93 sggpnftptlretRATLFAYYAAEEALthaKLLESPAKRILASFAkERIGVNIGVGMPSLADVGDVSYSLYADPEKvnys 172
Cdd:PRK08722  70 -------------KMDLFIQYGIAAGI---QALDDSGLEVTEENA-HRIGVAIGSGIGGLGLIEAGHQALVEKGPR---- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  173 RVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRA 252
Cdd:PRK08722 129 KVSPFFVPSTIVNMIAGNLSIMRGLRGPNIAISTACTTGLHNIGHAARMIAYGDADAMVAGGAEKASTPLGMAGFGAAKA 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  253 LCTKyNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQLCLRSA 332
Cdd:PRK08722 209 LSTR-NDEPQKASRPWDKDRDGFVLGDGAGMMVLEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPSEDGSGGALAMEAA 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  333 LEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGTssrrRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQ 411
Cdd:PRK08722 288 MRDAG-VTGEQIGYVNAHGTSTpAGDVAEIKGIKRALGEAGS----KQVLVSSTKSMTGHLLGAAGSVEAIITVMSLVDQ 362

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 71425875  412 QAPPNINLHAPSaEGLErLQLVRGHAPLPFQGDAVISTSFGFGGVNTALLFTRV 465
Cdd:PRK08722 363 IVPPTINLDDPE-EGLD-IDLVPHTARKVESMEYAICNSFGFGGTNGSLIFKKM 414

PRK07910

beta-ketoacyl-ACP synthase;

16-464

1.43e-75

beta-ketoacyl-ACP synthase;

Pssm-ID: 236129 [Multi-domain] Cd Length: 418 Bit Score: 243.10 E-value: 1.43e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   16 VVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKEvPFF----FPACI------DSDCRLTPAA-RQKSHEQllaKMPCQ 84
Cdd:PRK07910  14 VVVTGIAMTTALATDAETTWKLLLDGQSGIRTLDD-PFVeefdLPVRIgghlleEFDHQLTRVElRRMSYLQ---RMSTV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   85 VAAPVLAPSGGPNFTPtlretratlfayyaaeealthakllespakrilasfakERIGVNIGVGMPSLADVGDVsyslYA 164
Cdd:PRK07910  90 LGRRVWENAGSPEVDT--------------------------------------NRLMVSIGTGLGSAEELVFA----YD 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  165 DPEKVNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSI 244
Cdd:PRK07910 128 DMRARGLRAVSPLAVQMYMPNGPAAAVGLERHAKAGVITPVSACASGSEAIAQAWRQIVLGEADIAICGGVETRIEAVPI 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  245 AGFSRMRALCTKYNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRG 324
Cdd:PRK07910 208 AGFAQMRIVMSTNNDDPAGACRPFDKDRDGFVFGEGGALMVIETEEHAKARGANILARIMGASITSDGFHMVAPDPNGER 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  325 AQLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDgtssrRRPVYVSsvKGGLGHLLGAAGSVEAIV 403
Cdd:PRK07910 288 AGHAMTRAIELAG-LTPGDIDHVNAHATGTsVGDVAEGKAINNALGGH-----RPAVYAP--KSALGHSVGAVGAVESIL 359

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71425875  404 AIMSLYHQQAPPNINLHAPSAEglERLQLVRGHaPLPFQGDAVISTSFGFGGVNTALLFTR 464
Cdd:PRK07910 360 TVLALRDGVIPPTLNLENLDPE--IDLDVVAGE-PRPGNYRYAINNSFGFGGHNVALAFGR 417

PRK07967

beta-ketoacyl-ACP synthase I;

14-467

2.48e-74

beta-ketoacyl-ACP synthase I;

Pssm-ID: 181184 [Multi-domain] Cd Length: 406 Bit Score: 239.19 E-value: 2.48e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRplkevpfffpacidsdcrltpaarqKSHEQLLAKMPCQVA-APVLAP 92
Cdd:PRK07967   2 RRVVITGLGIVSSIGNNQQEVLASLREGRSGIT-------------------------FSPEFAEMGMRSQVWgNVKLDP 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   93 SGGPNFTPTLRETRATLFAYYAAEEALTHAKLLESpakrilaSFAKERIGVNIGVGMPS---LADVGDVSYslyadpEKV 169
Cdd:PRK07967  57 TGLIDRKVMRFMGDASAYAYLAMEQAIADAGLSEE-------QVSNPRTGLIAGSGGGStrnQVEAADAMR------GPR 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  170 NYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAgFSR 249
Cdd:PRK07967 124 GPKRVGPYAVTKAMASTVSACLATPFKIKGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELDWEMSCL-FDA 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  250 MRALCTKYNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAphPEGRGAQLCL 329
Cdd:PRK07967 203 MGALSTKYNDTPEKASRAYDANRDGFVIAGGGGVVVVEELEHALARGAKIYAEIVGYGATSDGYDMVA--PSGEGAVRCM 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  330 RSALEDGGnisiNDVAYVNAHATGT-IGDDMELHALDKVLgGDGTSSrrrpvyVSSVKGGLGHLLGAAGSVEAIVAIMSL 408
Cdd:PRK07967 281 QMALATVD----TPIDYINTHGTSTpVGDVKELGAIREVF-GDKSPA------ISATKSLTGHSLGAAGVQEAIYSLLMM 349

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71425875  409 YHQQAPPNINLHA--PSAEGLERLQLVRGHAPLpfqgDAVISTSFGFGGVNTALLFTRVEK 467
Cdd:PRK07967 350 EHGFIAPSANIEEldPQAAGMPIVTETTDNAEL----TTVMSNSFGFGGTNATLVFRRYKG 406

PRK14691

3-oxoacyl-(acyl carrier protein) synthase II; Provisional

118-464

9.76e-74

3-oxoacyl-(acyl carrier protein) synthase II; Provisional

Pssm-ID: 173154 [Multi-domain] Cd Length: 342 Bit Score: 235.78 E-value: 9.76e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  118 ALTHAKLLESPAKrilasfAKERIGVNIGvGMPSLADVgdVSYSLYADPEkvnysRVNPLFVPKILGNMVTGLTAMKYGI 197
Cdd:PRK14691  15 SLTHADNTEKQER------TATIIGAGIG-GFPAIAHA--VRTSDSRGPK-----RLSPFTVPSFLVNLAAGHVSIKHHF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  198 MGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRALCTKYNGMPQEASRPFDKDRGGFVM 277
Cdd:PRK14691  81 KGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGFVM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  278 GEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQLCLRSALEDGGnISINDVAYVNAHATGT-IG 356
Cdd:PRK14691 161 GEGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAG-ITPEQVQHLNAHATSTpVG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  357 DDMELHALDKVLGgdgtssRRRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLHA--PSAEGlerLQLVR 434
Cdd:PRK14691 240 DLGEINAIKHLFG------ESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENpdPAAKG---LNIIA 310

                        330       340       350
                 ....*....|....*....|....*....|
gi 71425875  435 GHAPlPFQGDAVISTSFGFGGVNTALLFTR 464
Cdd:PRK14691 311 GNAQ-PHDMTYALSNGFGFAGVNASILLKR 339

PRK06501

beta-ketoacyl-ACP synthase;

11-468

1.08e-67

beta-ketoacyl-ACP synthase;

Pssm-ID: 235817 [Multi-domain] Cd Length: 425 Bit Score: 222.58 E-value: 1.08e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   11 FIRRRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKEvpffFPAcidsdcrltpaarqkshEQLLAKMpcqvaapvl 90
Cdd:PRK06501   8 LGRPIVAVTGMGVVTSLGQGKADNWAALTAGESGIHTITR----FPT-----------------EGLRTRI--------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   91 apSGGPNFTPTLRETRATL---FAYYAAEEALTHAKL-----------------LESPAKRILAsfakERIGVNIGVGmp 150
Cdd:PRK06501  58 --AGTVDFLPESPFGASALseaLARLAAEEALAQAGIgkgdfpgplflaappveLEWPARFALA----AAVGDNDAPS-- 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  151 sladvgdvsyslYADPEKVNYSRVNPLFVPKILGNMVTGLTAMKYGIMG-PVGSSvAACATGAHCIGEAAEWIRGGRADI 229
Cdd:PRK06501 130 ------------YDRLLRAARGGRFDALHERFQFGSIADRLADRFGTRGlPISLS-TACASGATAIQLGVEAIRRGETDR 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  230 VVCGGTEACITPVSIAGFSRMRALCTKyNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGIS 309
Cdd:PRK06501 197 ALCIATDGSVSAEALIRFSLLSALSTQ-NDPPEKASKPFSKDRDGFVMAEGAGALVLESLESAVARGAKILGIVAGCGEK 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  310 SDAHDLAAPHPEGRGAQLCLRSALEDGGnISINDVAYVNAHATGTIGDD-MELHALDKVLGgdgtsSRRRPVYVSSVKGG 388
Cdd:PRK06501 276 ADSFHRTRSSPDGSPAIGAIRAALADAG-LTPEQIDYINAHGTSTPENDkMEYLGLSAVFG-----ERLASIPVSSNKSM 349

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  389 LGHLLGAAGSVEAIVAIMSLYHQQAPPNINLHAPSAEGLerLQLVRGHAPlPFQGDAVISTSFGFGGVNTALLFTRvEKA 468
Cdd:PRK06501 350 IGHTLTAAGAVEAVFSLLTIQTGRLPPTINYDNPDPAIP--LDVVPNVAR-DARVTAVLSNSFGFGGQNASLVLTA-EPA 425

elong_cond_enzymes

cd00828

"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ...

14-461

2.54e-67

"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as primer substrates, as well as the nature of their active site residues.

Pssm-ID: 238424 [Multi-domain] Cd Length: 407 Bit Score: 221.16 E-value: 2.54e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  14 RRVVVTGLGAVTPLG---LDVASTWAALCQGRSATRPLKEVPFFFPAcidsdcrltPAARQKSHEQLLAKMPCQvaapvl 90
Cdd:cd00828   1 SRVVITGIGVVSPHGegcDEVEEFWEALREGRSGIAPVARLKSRFDR---------GVAGQIPTGDIPGWDAKR------ 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  91 apsggpnftpTLRETRATLFAYYAAEEALTHAKLleSPAKRILASfakeRIGVNIGVGMPSLADVGDVSYSLYadpekvn 170
Cdd:cd00828  66 ----------TGIVDRTTLLALVATEEALADAGI--TDPYEVHPS----EVGVVVGSGMGGLRFLRRGGKLDA------- 122

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 171 ySRVNPLFVPK--ILGNMVTGLTAMKYGIM-GPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEAcITPVSIAGF 247
Cdd:cd00828 123 -RAVNPYVSPKwmLSPNTVAGWVNILLLSShGPIKTPVGACATALEALDLAVEAIRSGKADIVVVGGVED-PLEEGLSGF 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 248 SRMRALCTKYNGmPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPeGRGAQL 327
Cdd:cd00828 201 ANMGALSTAEEE-PEEMSRPFDETRDGFVEAEGAGVLVLERAELALARGAPIYGRVAGTASTTDGAGRSVPAG-GKGIAR 278

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 328 CLRSALeDGGNISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGtssrrRPVYVSSVKGGLGHLLGAAGSVEAIVAIM 406
Cdd:cd00828 279 AIRTAL-AKAGLSLDDLDVISAHGTSTpANDVAESRAIAEVAGALG-----APLPVTAQKALFGHSKGAAGALQLIGALQ 352

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 71425875 407 SLYHQQAPPNINLHAPsAEGLERLQLVRGHAPLPFQGDAVISTSFGFGGVNTALL 461
Cdd:cd00828 353 SLEHGLIPPTANLDDV-DPDVEHLSVVGLSRDLNLKVRAALVNAFGFGGSNAALV 406

PRK09116

beta-ketoacyl-ACP synthase;

14-462

6.14e-66

beta-ketoacyl-ACP synthase;

Pssm-ID: 181657 [Multi-domain] Cd Length: 405 Bit Score: 217.55 E-value: 6.14e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKEVPFFfpacidsdcrltpaarqkshEQLLAKMpcqvAAPVlaps 93
Cdd:PRK09116   2 RRVVVTGMGGVTALGEDWQTIAARLKAGRNAVRRMPEWDRY--------------------DGLNTRL----AAPI---- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   94 ggPNFTP----TLRETRA----TLFAYYAAEEALTHAKLLESPakrilaSFAKERIGVNIGVGMPSLADVGDVsyslyad 165
Cdd:PRK09116  54 --DDFELpahyTRKKIRSmgrvSLMATRASELALEDAGLLGDP------ILTDGRMGIAYGSSTGSTDPIGAF------- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  166 pekvnysrvnplfvpkilGNMVT-----GLTAMKY----------------GIMGPVGSSVAACATGAHCIGEAAEWIRG 224
Cdd:PRK09116 119 ------------------GTMLLegsmsGITATTYvrmmphttavnvglffGLKGRVIPTSSACTSGSQGIGYAYEAIKY 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  225 GRADIVVCGGTEAcITPVSIAGFSRMRALCTKyNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELR 304
Cdd:PRK09116 181 GYQTVMLAGGAEE-LCPTEAAVFDTLFATSTR-NDAPELTPRPFDANRDGLVIGEGAGTLVLEELEHAKARGATIYAEIV 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  305 GFGISSDAHDLAAPHPEgrGAQLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGgdgtssRRRPvyVS 383
Cdd:PRK09116 259 GFGTNSDGAHVTQPQAE--TMQIAMELALKDAG-LAPEDIGYVNAHGTATdRGDIAESQATAAVFG------ARMP--IS 327

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71425875  384 SVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLHAPSAEgLERLQLVRGhAPLPFQGDAVISTSFGFGGVNTALLF 462
Cdd:PRK09116 328 SLKSYFGHTLGACGALEAWMSIEMMNEGWFAPTLNLTQVDPA-CGALDYIMG-EAREIDTEYVMSNNFAFGGINTSLIF 404

PRK05952

beta-ketoacyl-ACP synthase;

15-460

2.47e-65

beta-ketoacyl-ACP synthase;

Pssm-ID: 235653 [Multi-domain] Cd Length: 381 Bit Score: 215.30 E-value: 2.47e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   15 RVVVTGLGAVTPLGlDVASTWAALCQGRSATRPLKEVPFFFPacidsdcrlTPAArqksheqLLAKMPCQVaapvlapsg 94
Cdd:PRK05952   3 KVVVTGIGLVSALG-DLEQSWQRLLQGKSGIKLHQPFPELPP---------LPLG-------LIGNQPSSL--------- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   95 gpnftPTLRETratlfayyAAEEALTHAKLleSPAkriLASfakerIGVNIGVGMPSLADVGDVSYSLYADPEKVNYSRV 174
Cdd:PRK05952  57 -----EDLTKT--------VVTAALKDAGL--TPP---LTD-----CGVVIGSSRGCQGQWEKLARQMYQGDDSPDEELD 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  175 NPLFVpKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRALC 254
Cdd:PRK05952 114 LENWL-DTLPHQAAIAAARQIGTQGPVLAPMAACATGLWAIAQGVELIQTGQCQRVIAGAVEAPITPLTLAGFQQMGALA 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  255 tkyngmpQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQLCLRSALE 334
Cdd:PRK05952 193 -------KTGAYPFDRQREGLVLGEGGAILVLESAELAQKRGAKIYGQILGFGLTCDAYHMSAPEPDGKSAIAAIQQCLA 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  335 DGGnISINDVAYVNAHATGTIGDDMELHALDKVLGGDGtssrrrpVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAP 414
Cdd:PRK05952 266 RSG-LTPEDIDYIHAHGTATRLNDQREANLIQALFPHR-------VAVSSTKGATGHTLGASGALGVAFSLLALRHQQLP 337

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 71425875  415 PNINLHAPSAEglerLQLVRghAPLPFQGDAVISTSFGFGGVNTAL 460
Cdd:PRK05952 338 PCVGLQEPEFD----LNFVR--QAQQSPLQNVLCLSFGFGGQNAAI 377

PKS

cd00833

polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different ...

15-461

5.56e-54

polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.

Pssm-ID: 238429 [Multi-domain] Cd Length: 421 Bit Score: 186.22 E-value: 5.56e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  15 RVVVTGLGAVTPLGLDVASTWAALCQGRSATRplkEVPFffpacidsdcRLTPAARQKSHEQLLAKMPCQVAAPVLAPSG 94
Cdd:cd00833   2 PIAIVGMACRFPGAADPDEFWENLLEGRDAIS---EIPE----------DRWDADGYYPDPGKPGKTYTRRGGFLDDVDA 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  95 GPN--FTPTLRETRAT-----LF---AYyaaeEALTHAKLlespakrILASFAKERIGVNIGVgmpsladvgdvSYSLYA 164
Cdd:cd00833  69 FDAafFGISPREAEAMdpqqrLLlevAW----EALEDAGY-------SPESLAGSRTGVFVGA-----------SSSDYL 126

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 165 DPEKVNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPvgsSV---AACATGAHCIGEAAEWIRGGRADIVVCGGTEACITP 241
Cdd:cd00833 127 ELLARDPDEIDAYAATGTSRAFLANRISYFFDLRGP---SLtvdTACSSSLVALHLACQSLRSGECDLALVGGVNLILSP 203

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 242 VSIAGFSRMRALCtkyngmPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPE 321
Cdd:cd00833 204 DMFVGFSKAGMLS------PDGRCRPFDADADGYVRGEGVGVVVLKRLSDALRDGDRIYAVIRGSAVNQDGRTKGITAPS 277

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 322 GRGAQLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDgtSSRRRPVYVSSVKGGLGHLLGAAGSVE 400
Cdd:cd00833 278 GEAQAALIRRAYARAG-VDPSDIDYVEAHGTGTpLGDPIEVEALAKVFGGS--RSADQPLLIGSVKSNIGHLEAAAGLAG 354

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71425875 401 AIVAIMSLYHQQAPPNINLHAPSAE-GLERLQLVRGHAPLPFQGD-----AVIStSFGFGGVNTALL 461
Cdd:cd00833 355 LIKVVLALEHGVIPPNLHFETPNPKiDFEESPLRVPTEARPWPAPagprrAGVS-SFGFGGTNAHVI 420

PRK07103

polyketide beta-ketoacyl:acyl carrier protein synthase; Validated

15-464

7.30e-53

polyketide beta-ketoacyl:acyl carrier protein synthase; Validated

Pssm-ID: 180839 [Multi-domain] Cd Length: 410 Bit Score: 183.31 E-value: 7.30e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   15 RVVVTGLGAVTPLGLDVASTWAALCQGRSATRplkevpfffpacidsdcRLTPAARQKSHEQLLAKMPCQVAAPVLAPSG 94
Cdd:PRK07103   3 EVVVTGVGVVSAIGQGRPSFAAALLAGRHAFG-----------------VMRRPGRQVPDDAGAGLASAFIGAELDSLAL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   95 GPNFTPTLR-----ETRATLFAyyaAEEALTHAKLLESPakrilasfaKERIGVNIG---VGMPSLADVgdvsYSLYADp 166
Cdd:PRK07103  66 PERLDAKLLrraslSAQAALAA---AREAWRDAALGPVD---------PDRIGLVVGgsnLQQREQALV----HETYRD- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  167 ekvnysrvNPLFVPK--ILGNMVT---GLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITP 241
Cdd:PRK07103 129 --------RPAFLRPsyGLSFMDTdlvGLCSEQFGIRGEGFTVGGASASGQLAVIQAARLVQSGSVDACIAVGALMDLSY 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  242 VSIAGFSRMRALCT-KYNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHP 320
Cdd:PRK07103 201 WECQALRSLGAMGSdRFADEPEAACRPFDQDRDGFIYGEACGAVVLESAESARRRGARPYAKLLGWSMRLDANRGPDPSL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  321 EGRGAqlCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDkvlggdgtSSRRRPVYVSSVKGGLGHLLGAAGSV 399
Cdd:PRK07103 281 EGEMR--VIRAALRRAG-LGPEDIDYVNPHGTGSpLGDETELAALF--------ASGLAHAWINATKSLTGHGLSAAGIV 349

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71425875  400 EAIVAIMSLYHQQAPPNINLHAPSAeglERLQLVRGHaPLPFQGDAVISTSFGFGGVNTALLFTR 464
Cdd:PRK07103 350 ELIATLLQMRAGFLHPSRNLDEPID---ERFRWVGST-AESARIRYALSLSFGFGGINTALVLER 410

PRK09185

beta-ketoacyl-ACP synthase;

16-464

1.17e-47

beta-ketoacyl-ACP synthase;

Pssm-ID: 236398 [Multi-domain] Cd Length: 392 Bit Score: 168.87 E-value: 1.17e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   16 VVVTGLGAVTPLGLDVASTWAALCQGRSA-----TRPLKEVPFFFPACIDSDCRLTPAArqksheqlLAKMPCqvaapvl 90
Cdd:PRK09185   4 VYISAFGATSALGRGLDAILAALRAGRASgmrpcDFWLVDLPTWVGEVVGVELPALPAA--------LAAFDC------- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   91 apsggpnftptlRETRATLFAYYAAEEALTHAKllespakrilASFAKERIGVNIGVGMPSLADvGDVSYSLY-----AD 165
Cdd:PRK09185  69 ------------RNNRLALLALQQIEPAVEAAI----------ARYGADRIGVVLGTSTSGILE-GELAYRRRdpahgAL 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  166 PEKVNYSRVNPLFVPKILGNmVTGLTAMKYGImgpvgSSvaACATGAHCIGEAAEWIRGGRADIVVCGGTEA-CITPVSi 244
Cdd:PRK09185 126 PADYHYAQQELGSLADFLRA-YLGLSGPAYTI-----ST--ACSSSAKVFASARRLLEAGLCDAAIVGGVDSlCRLTLN- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  245 aGFSRMRALCTkyngmpqEASRPFDKDRGGFVMGEGSGIIVLEhlehamqRGAQIFAELRGFGISSDAHDLAAPHPEGRG 324
Cdd:PRK09185 197 -GFNSLESLSP-------QPCRPFSANRDGINIGEAAAFFLLE-------REDDAAVALLGVGESSDAHHMSAPHPEGLG 261

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  325 AQLCLRSALEDGGnISINDVAYVNAHATGTIGDD-MELHALDKVLGGDgtssrrrpVYVSSVKGGLGHLLGAAGSVEAIV 403
Cdd:PRK09185 262 AILAMQQALADAG-LAPADIGYINLHGTATPLNDaMESRAVAAVFGDG--------VPCSSTKGLTGHTLGAAGAVEAAI 332

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71425875  404 AIMSLYHQQAPPNINLHAPSAEgLERLQLVRGHAPLPFQgdAVISTSFGFGGVNTALLFTR 464
Cdd:PRK09185 333 CWLALRHGLPPHGWNTGQPDPA-LPPLYLVENAQALAIR--YVLSNSFAFGGNNCSLIFGR 390

decarbox_cond_enzymes

cd00825

decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new ...

105-461

5.37e-44

decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new carbon-carbon bond by a decarboxylating Claisen-like condensation reaction. Members are involved in the synthesis of fatty acids and polyketides, a diverse group of natural products. Both pathways are an iterative series of additions of small carbon units, usually acetate, to a nascent acyl group. There are 2 classes of decarboxylating condensing enzymes, which can be distinguished by sequence similarity, type of active site residues and type of primer units (acetyl CoA or acyl carrier protein (ACP) linked units).

Pssm-ID: 238421 [Multi-domain] Cd Length: 332 Bit Score: 157.41 E-value: 5.37e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 105 TRATLFAYYAAEEALTHAKLLESPAKrilasfaKERIGVNIGVGMPSladvgdvsySLYADPEKVNYSRVNPLFVPKILG 184
Cdd:cd00825   9 SYVSILGFEAAERAIADAGLSREYQK-------NPIVGVVVGTGGGS---------PRFQVFGADAMRAVGPYVVTKAMF 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 185 NMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRALctkyngMPQEA 264
Cdd:cd00825  73 PGASGQIATPLGIHGPAYDVSAACAGSLHALSLAADAVQNGKQDIVLAGGSEELAAPMDCEFDAMGALS------TPEKA 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 265 SRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDLAAPHPEGRGAQLCLRSALEdGGNISINDV 344
Cdd:cd00825 147 SRTFDAAADGFVFGDGAGALVVEELEHALARGAHIYAEIVGTAATIDGAGMGAFAPSAEGLARAAKEALA-VAGLTVWDI 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 345 AYVNAHATGT-IGDDMELHALDKVLGGdgtssrrRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLhaps 423
Cdd:cd00825 226 DYLVAHGTGTpIGDVKELKLLRSEFGD-------KSPAVSATKAMTGNLSSAAVVLAVDEAVLMLEHGFIPPSIHI---- 294

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 71425875 424 aEGLERLQLVRGHAPLPFQGDAVISTSFGFGGVNTALL 461
Cdd:cd00825 295 -EELDEAGLNIVTETTPRELRTALLNGFGLGGTNATLV 331

PksD

COG3321

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...

134-457

6.38e-42

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 159.65 E-value: 6.38e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  134 ASFAKERIGVNIGVGMpsladvGDVSYSLYADPEKVNysrvnPLFVPKILGNMVTGLTAMKYGIMGPvgsSVA---ACAT 210
Cdd:COG3321  111 ESLAGSRTGVFVGASS------NDYALLLLADPEAID-----AYALTGNAKSVLAGRISYKLDLRGP---SVTvdtACSS 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  211 GAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRALCtkyngmPQEASRPFDKDRGGFVMGEGSGIIVLEHLE 290
Cdd:COG3321  177 SLVAVHLACQSLRSGECDLALAGGVNLMLTPESFILFSKGGMLS------PDGRCRAFDADADGYVRGEGVGVVVLKRLS 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  291 HAMQRGAQIFAELRGFGISSDAHD--LAAPHPEGRgaQLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKV 367
Cdd:COG3321  251 DALRDGDRIYAVIRGSAVNQDGRSngLTAPNGPAQ--AAVIRRALADAG-VDPATVDYVEAHGTGTpLGDPIEAAALTAA 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  368 LGGDGtsSRRRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLHAPS-----AEGleRLQLVRGHAPLPFQ 442
Cdd:COG3321  328 FGQGR--PADQPCAIGSVKSNIGHLEAAAGVAGLIKAVLALRHGVLPPTLHFETPNphidfENS--PFYVNTELRPWPAG 403

                        330
                 ....*....|....*...
gi 71425875  443 GD---AVIStSFGFGGVN 457
Cdd:COG3321  404 GGprrAGVS-SFGFGGTN 420

ketoacyl-synt

pfam00109

Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar ...

14-292

4.26e-40

Pssm-ID: 425468 [Multi-domain] Cd Length: 251 Bit Score: 144.70 E-value: 4.26e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKevpfffpacidsDCRLTPAARQKSHEQLLAKMPCQVAAPVlaps 93
Cdd:pfam00109   1 EPVAIVGMGCRFPGGNDPEEFWENLLEGRDGISEIP------------ADRWDPDKLYDPPSRIAGKIYTKWGGLD---- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    94 GGPNFTPTL-----RETRAT----LFAYYAAEEALTHAKLLEspakrilASFAKERIGVNIGVGMPSLADvgdvsysLYA 164
Cdd:pfam00109  65 DIFDFDPLFfgispREAERMdpqqRLLLEAAWEALEDAGITP-------DSLDGSRTGVFIGSGIGDYAA-------LLL 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   165 DPEKVNYSRVNPLFVPKIlGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSI 244
Cdd:pfam00109 131 LDEDGGPRRGSPFAVGTM-PSVIAGRISYFLGLRGPSVTVDTACSSSLVAIHAAVQSIRSGEADVALAGGVNLLLTPLGF 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 71425875   245 AGFSRMRALCTkyNGmPQEASRPFDKdrgGFVMGEGSGIIVLEHLEHA 292
Cdd:pfam00109 210 AGFSAAGMLSP--DG-PCKAFDPFAD---GFVRGEGVGAVVLKRLSDA 251

Ketoacyl-synt_C

pfam02801

Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar ...

300-420

4.92e-34

Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.

Pssm-ID: 426989 Cd Length: 118 Bit Score: 123.83 E-value: 4.92e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875   300 FAELRGFGISSDAHDLAAPHPEGRGAQLCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDGtssRRR 378
Cdd:pfam02801   1 YAVIKGSAVNHDGRHNGLTAPNGEGQARAIRRALADAG-VDPEDVDYVEAHGTGTpLGDPIEAEALKRVFGSGA---RKQ 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 71425875   379 PVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLH 420
Cdd:pfam02801  77 PLAIGSVKSNIGHLEGAAGAAGLIKVVLALRHGVIPPTLNLE 118

omega_3_PfaA

TIGR02813

polyketide-type polyunsaturated fatty acid synthase PfaA; Members of the seed for this ...

107-457

7.43e-31

polyketide-type polyunsaturated fatty acid synthase PfaA; Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.

Pssm-ID: 274311 [Multi-domain] Cd Length: 2582 Bit Score: 127.04 E-value: 7.43e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    107 ATLFAYYAAEEALTHAKLLESpakrilasFAKERIGVNIGVG--------------MPSLADVGDVSYSLYADPE----- 167
Cdd:TIGR02813   93 SQLLSLVVAKEVLNDAGLPDG--------YDRDKIGITLGVGggqkqssslnarlqYPVLKKVFKASGVEDEDSEmlikk 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    168 -KVNYSRVNPLFVPKILGNMVTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAG 246
Cdd:TIGR02813  165 fQDQYIHWEENSFPGSLGNVISGRIANRFDLGGMNCVVDAACAGSLAAIRMALSELLEGRSEMMITGGVCTDNSPFMYMS 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    247 FSRMRALCTkyngmpQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAH--DLAAPHPEGRG 324
Cdd:TIGR02813  245 FSKTPAFTT------NEDIQPFDIDSKGMMIGEGIGMMALKRLEDAERDGDRIYAVIKGVGASSDGKfkSIYAPRPEGQA 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    325 AqlCLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGGDgtSSRRRPVYVSSVKGGLGHLLGAAGSVEAIV 403
Cdd:TIGR02813  319 K--ALKRAYDDAG-FAPHTCGLIEAHGTGTaAGDVAEFGGLVSVFSQD--NDQKQHIALGSVKSQIGHTKSTAGTAGMIK 393

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71425875    404 AIMSLYHQQAPPNINLHAPSAE-GLERLQLVRGHAPLPFQG-------DAVIStSFGFGGVN 457
Cdd:TIGR02813  394 AVLALHHKVLPPTINVDQPNPKlDIENSPFYLNTETRPWMQredgtprRAGIS-SFGFGGTN 454

CLF

cd00832

Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic ...

14-461

8.22e-27

Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein (ACP). CLFs are similar to other elongation ketosynthase domains, but their active site cysteine is replaced by a conserved glutamine.

Pssm-ID: 238428 [Multi-domain] Cd Length: 399 Bit Score: 111.68 E-value: 8.22e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  14 RRVVVTGLGAVTPLGLDVASTWAALCQGRSATRPLKevpfffpacidsdcRLTPAARqksheqllakmPCQVAAPVlaps 93
Cdd:cd00832   1 RRAVVTGIGVVAPNGLGVEEYWKAVLDGRSGLGPIT--------------RFDPSGY-----------PARLAGEV---- 51

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875  94 ggPNFTPT-------LRET-RATLFAYYAAEEALTHAKLleSPAKriLASFakerigvniGVGMPSLADVGDVSYS---- 161
Cdd:cd00832  52 --PDFDAAehlpgrlLPQTdRMTRLALAAADWALADAGV--DPAA--LPPY---------DMGVVTASAAGGFEFGqrel 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 162 --LYAD-PEKVN-------YSRVNplfvpkilgnmvTGLTAMKYGIMGPVGSSVAACATGAHCIGEAAEWIRGGrADIVV 231
Cdd:cd00832 117 qkLWSKgPRHVSayqsfawFYAVN------------TGQISIRHGMRGPSGVVVAEQAGGLDALAQARRLVRRG-TPLVV 183

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 232 CGGTEACITPVSIAGFSRMRALCTkyNGMPQEASRPFDKDRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSD 311
Cdd:cd00832 184 SGGVDSALCPWGWVAQLSSGRLST--SDDPARAYLPFDAAAAGYVPGEGGAILVLEDAAAARERGARVYGEIAGYAATFD 261

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 312 ahdlAAPHPeGRGAQL--CLRSALEDGGnISINDVAYVNAHATGT-IGDDMELHALDKVLGgdgtssrRRPVYVSSVKGG 388
Cdd:cd00832 262 ----PPPGS-GRPPGLarAIRLALADAG-LTPEDVDVVFADAAGVpELDRAEAAALAAVFG-------PRGVPVTAPKTM 328

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71425875 389 LGHLLGAAGSVEAIVAIMSLYHQQAPPNINLHAPSAEglERLQLVRGhAPLPFQGDAVISTSFGFGGVNTALL 461
Cdd:cd00832 329 TGRLYAGGAPLDVATALLALRDGVIPPTVNVTDVPPA--YGLDLVTG-RPRPAALRTALVLARGRGGFNSALV 398

cond_enzymes

cd00327

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ...

187-461

4.06e-24

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.

Pssm-ID: 238201 [Multi-domain] Cd Length: 254 Bit Score: 100.98 E-value: 4.06e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 187 VTGLTAMKYGIM-GPVGSSVAACATGAHCIGEAAEWIRGGRADIVVCGGTEACITpvsiagfsrmralctkyngmpqeas 265
Cdd:cd00327  46 AAGQLAYHLGISgGPAYSVNQACATGLTALALAVQQVQNGKADIVLAGGSEEFVF------------------------- 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 266 rpfdkdrggfvmGEGSGIIVLEHLEHAMQRGAQIFAELRGFGISSDAHDlAAPHPEGRGAQLCLRSALEdGGNISINDVA 345
Cdd:cd00327 101 ------------GDGAAAAVVESEEHALRRGAHPQAEIVSTAATFDGAS-MVPAVSGEGLARAARKALE-GAGLTPSDID 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875 346 YVNAHATGT-IGDDMELHALDKVLGGdgtssrrRPVYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHqqappninlhapsa 424
Cdd:cd00327 167 YVEAHGTGTpIGDAVELALGLDPDGV-------RSPAVSATLIMTGHPLGAAGLAILDELLLMLEH-------------- 225

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 71425875 425 eglerlqlvRGHAPLPFQGDAVISTSFGFGGVNTALL 461
Cdd:cd00327 226 ---------EFIPPTPREPRTVLLLGFGLGGTNAAVV 253

PKS_KS

smart00825

Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the ...

207-461

2.87e-23

Pssm-ID: 214836 [Multi-domain] Cd Length: 298 Bit Score: 99.33 E-value: 2.87e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    207 ACATGAHCIGEAAEWIRGGRADIVVCGGTEACITPVSIAGFSRMRALCtkyngmPQEASRPFDKDRGGFVMGEGSGIIVL 286
Cdd:smart00825  96 ACSSSLVALHLACQSLRSGECDMALAGGVNLILSPDTFVGLSRAGMLS------PDGRCKTFDASADGYVRGEGVGVVVL 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    287 EHLEHAMQRGAQIFAELRGFGISSDAHD--LAAPHPEgrgAQLclrsaledggnisindvayvnahatgtigddmelhal 364
Cdd:smart00825 170 KRLSDALRDGDPILAVIRGSAVNQDGRSngITAPSGP---AQL------------------------------------- 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71425875    365 dkvlggdgtssrrrpvYVSSVKGGLGHLLGAAGSVEAIVAIMSLYHQQAPPNINLHAPS-----AEGleRLQLVRGHAPL 439
Cdd:smart00825 210 ----------------LIGSVKSNIGHLEAAAGVAGLIKVVLALKHGVIPPTLHFETPNphidlEES--PLRVPTELTPW 271

                          250       260
                   ....*....|....*....|....*
gi 71425875    440 PFQGD---AVIStSFGFGGVNTALL 461
Cdd:smart00825 272 PPPGRprrAGVS-SFGFGGTNAHVI 295

PRK06519

beta-ketoacyl-ACP synthase;

271-303

4.06e-03

beta-ketoacyl-ACP synthase;

Pssm-ID: 235819 [Multi-domain] Cd Length: 398 Bit Score: 39.55 E-value: 4.06e-03

                         10        20        30
                 ....*....|....*....|....*....|...
gi 71425875  271 DRGGFVMGEGSGIIVLEHLEHAMQRGAQIFAEL 303
Cdd:PRK06519 235 DGGGFILGSGGAFLVLESREHAEARGARPYARI 267

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01