|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-439 |
4.16e-95 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 290.24 E-value: 4.16e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 18 RFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSA 97
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 98 FTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVF 177
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 178 FSFAIPGIVAAIAWYLLVkskpaesgfvsqselaeinagreshnnsvreniliaerftwldkiirvkkmapidtakglft 257
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 258 sKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLL-GRRRKPTMMFTAV 336
Cdd:cd17319 179 -RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrGARRLVIIIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 337 STVVMMLIMLNipASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTG 416
Cdd:cd17319 258 AAVGLLLAYLT--TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATG 335
|
410 420
....*....|....*....|...
gi 378977814 417 SFNSVFTYFGICAAIGLVVILFL 439
Cdd:cd17319 336 SYTAAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-439 |
9.08e-68 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 220.13 E-value: 9.08e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 11 DARKTKYRFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSL 90
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 91 SIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVT 170
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 171 WGWRWVFFSFAIPGIVAAIAWYLLVkskpaesgfvsqselaeinagreshnnsvreniliaerftwldkiirvkkmapid 250
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWLL------------------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 251 takglftsknilgdCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKlLGRRRKPT 330
Cdd:COG2271 186 --------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR-LGRRRKLV 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 331 MMFTAVSTVVMMLIMLNIPASTLAVcIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGF 410
Cdd:COG2271 251 LAIGLLLAALALLLLALLPSPALAI-ALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGY 329
|
410 420
....*....|....*....|....*....
gi 378977814 411 LLDKTGsFNSVFTYFGICAAIGLVVILFL 439
Cdd:COG2271 330 LLDATG-YQAAFLLLAALALLAALLALLL 357
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
27-439 |
5.54e-58 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 195.63 E-value: 5.54e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 27 LVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVS 106
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 107 SVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIV 186
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 187 AAIAWYLLVKSKPAESGFVSQSELAEINAGREShnnsvreniliaerftwlDKIIRVKKMAPIDTAKGLFTSKNILGDCL 266
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLA------------------EQQGKGPSTPKKYQIKELLKDRRVWGLAL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 267 AYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRK-------PTMMFTAVSTV 339
Cdd:TIGR00893 223 GQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfarktAIIAGLVLSLL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 340 VMMLIMLNIPASTLA-VCIGLFFVGFCLnIGWPAFTAYgmavSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSF 418
Cdd:TIGR00893 303 MFATNYVNIPYAALAlVALGFFGLGAGA-IGWALISDN----APGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSF 377
|
410 420
....*....|....*....|.
gi 378977814 419 NSVFTYFGICAAIGLVVILFL 439
Cdd:TIGR00893 378 AGALMVVAALALIGALSYLLL 398
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-439 |
1.04e-51 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 178.92 E-value: 1.04e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 16 KYRFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGF 95
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 96 SAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRW 175
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 176 VFFSFAIPGIVAAIAWYLLVKSKPAESGFVSQSELAEINAgreshnnsvreniliaerftwldkiirvkkmapidtakgL 255
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE---------------------------------------A 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 256 FTSKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKlLGRRRkpTMMFTA 335
Cdd:COG2223 202 LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR-IGGRR--VLLIVF 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 336 VSTVVMMLIMLNIPASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKT 415
Cdd:COG2223 279 ALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358
|
410 420
....*....|....*....|....
gi 378977814 416 GSFNSVFTYFGICAAIGLVVILFL 439
Cdd:COG2223 359 GSYTAAFLVFAVLALVALVLTLLL 382
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
26-416 |
3.26e-38 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 142.51 E-value: 3.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 26 FLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTV 105
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 106 SSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPL-AVWIAVTWGWRWVFFSFAIPG 184
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLvLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 185 IVAAIAWYLLVKSKPAESGfvsQSELAEINAGRESHNNSVRENILIAERFTwldkiirvkkmapidtAKGLFTSKNILGD 264
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCG---LPPAEEMPNEEPDGDAEKKEEELTKKQIF----------------LQYVLLNKVLWYI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 265 CLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRKPT-MMFTAVSTVVMML 343
Cdd:TIGR00881 222 SLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLaVFFMALIIVSLLV 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378977814 344 IMLNIPASTLAVCIGLFFVGFCLNIgwPAFTAyGMAVSD---SKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTG 416
Cdd:TIGR00881 302 YWLNPAANPLMDLICLFALGFLVYG--PQMLI-GVIASElapKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-404 |
1.60e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 128.94 E-value: 1.60e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 15 TKYRFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFG 94
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 95 FSAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWR 174
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 175 WVFFSFAIPGIVAAIAWYLLVKSKPAESGFVSQSELAEinagreshnnsvreniliaerftwldkiirvkkmapidtakg 254
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------------------------------------------ 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 255 LFTSKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgrRRKPTMMFT 334
Cdd:COG2814 203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF---GRRRLLLIG 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 335 AVSTVVMMLIMLNIPaSTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVA 404
Cdd:COG2814 280 LLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
13-443 |
1.60e-33 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 129.99 E-value: 1.60e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 13 RKTKYRFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSI 92
Cdd:COG2807 11 SRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 93 FGFSAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPpKEKATATGVYIAATMFAPIIVPPLAVWIAVTWG 172
Cdd:COG2807 91 LLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 173 WRWVFFSFAIPGIVAAIAWYLLVKSKPAESGFVSQSElaeinagreshnnsvreniliaerftwldkiirvkkmapidTA 252
Cdd:COG2807 170 WRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA-----------------------------------------SL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 253 KGLFTSKNILGDCLAYFMMVSVLYGLLTWIPLYLVkERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgRRRKPTMM 332
Cdd:COG2807 209 RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL--GDRRPLLL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 333 FTAVSTVVMMLIMLNIPASTLAVCIGLFfvGFCLNIGWP-AFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFL 411
Cdd:COG2807 286 LLGLLGLAGLLGLLLAPGSLPWLWAVLL--GLGQGGLFPlALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGAL 363
|
410 420 430
....*....|....*....|....*....|..
gi 378977814 412 LDKTGSFNSVFTYFGICAAIGLVVILFLDEPQ 443
Cdd:COG2807 364 HDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-405 |
6.04e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 124.45 E-value: 6.04e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 25 IFLVYAINYADRTNIGAVLP-FIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMG 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 104 TVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIP 183
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 184 GIVAAIAWYLLVKSKPAEsgfvsqselaeinagreshnnsvreniliaerftwlDKIIRVKKMAPIDTAKGLFTSKNILG 263
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESK------------------------------------RPKPAEEARLSLIVAWKALLRDPVLW 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 264 DCLAYFMMVSVLYGLLTWIPLYlVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKlLGRRRKPTMMFTAVSTVVMML 343
Cdd:pfam07690 205 LLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR-LGRRRRLLLALLLLILAALGL 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 378977814 344 IMLNIPASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAP 405
Cdd:pfam07690 283 LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-437 |
8.51e-31 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 122.15 E-value: 8.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 25 IFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGT 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 105 VSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIA--VTWGWRWVFFSFAI 182
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 183 PGIVAAIAWYLLVKSKPAESGFVSQSElaeinagreshnnsvreniliaerftwldkiirvKKMAPIDTAKGLFTSKNIL 262
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEA----------------------------------SSKSVLKLLKRVLKNPGLW 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 263 GDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRrkPTMMFTAVSTVVMM 342
Cdd:cd06174 207 LLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRK--PLLLIGLLLMALGL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 343 LIMLNIPASTLAVcIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNSVF 422
Cdd:cd06174 285 ALLLLAPSLLLLL-LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363
|
410
....*....|....*
gi 378977814 423 TYFGICAAIGLVVIL 437
Cdd:cd06174 364 LVLAVLLLLAAILLL 378
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
18-439 |
5.66e-30 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 119.30 E-value: 5.66e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 18 RFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSA 97
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 98 FTWLMGTVSSV--FGLKLVRLGLGLSEGPCPVGLasTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRW 175
Cdd:cd17312 81 ANIFMGFSTSLwfFAVLWGLNGLFQSMGWPPCVK--LLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 176 VFFSFAIPGIVAAIAWYLLVKSKPaesgfvsqselaeinagreshnnsvreniliaerftwldkiirvkkmapidtakgl 255
Cdd:cd17312 159 AFLVPGIVGLVVAIILFFFLRDSP-------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 256 ftsKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRKPTMMFTA 335
Cdd:cd17312 183 ---PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYM 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 336 VSTVVMMLIMLNIPASTLAVCIGLFFVGFClnIGWPAFTAYGMAVSDSKTYPIASS---IINSGGNLGGFVAPMAAGFLL 412
Cdd:cd17312 260 LLMTLSLALFWFFPHNKLLSIVLLFLIGFF--VGGPINLIGGAAAQDIGRKEAAGTatgFVGLFGYLGASLAGLPLGYII 337
|
410 420
....*....|....*....|....*..
gi 378977814 413 DKTGSFNSVFTYFGICAAIGLVVILFL 439
Cdd:cd17312 338 DHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
39-437 |
1.17e-28 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 116.18 E-value: 1.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGL 118
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 119 GLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLVKSK 198
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 199 PAESGfvsqselaeinagreshnnsvreniliaerftwldkiIRVKKMAPIDTAKGLFTSKNILGDCLAYFMMVSVLYGL 278
Cdd:cd17475 175 PAASA-------------------------------------ATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFAL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 279 LTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRKPTMMFTAVSTVVMMLIMLNIPASTLAVCIG 358
Cdd:cd17475 218 LTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLV 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 359 L--FFVGFCLnIGW-PAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNSVFTYFGICAAIGLVV 435
Cdd:cd17475 298 LllILLGLFA-IGWnGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALL 376
|
..
gi 378977814 436 IL 437
Cdd:cd17475 377 LL 378
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
24-438 |
6.05e-27 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 110.72 E-value: 6.05e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 24 MIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMG 103
Cdd:cd17380 3 LLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 104 TV--SSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAA----TMFAPIIVPPLAVWiavtWGWRWVF 177
Cdd:cd17380 83 LLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGsylgTLLGGLIGPLLLEY----YGWPSVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 178 FSFAIPGIVAAIAWYLLVKSkpaesgfvsqselaeinagreshnnsvreniliaerfTWldKIIrvkkmapidtakglft 257
Cdd:cd17380 159 YFFGLLGLLWALVWLIYLPP-------------------------------------VW--AII---------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 258 sknilgdcLAYFMMVSVLYGLLTWIPLYLvKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRKPTMMFTAVS 337
Cdd:cd17380 184 --------VAHFCMNWGFYILLSWLPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQ 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 338 TVVMML--IMLNIPASTLAVCIGLFFVgfCLNIGWPAFTAYGMAVSDSKTYPIASSII----NSGGNLGGFVAPMAAGFL 411
Cdd:cd17380 255 SIGFLGpaLFLLLLSHTDSFSLALLCM--SVALGLSAFSSSGVLVNHQDIAPNYAGIVfgisNTAGTIPGIVGVYLTGYI 332
|
410 420
....*....|....*....|....*..
gi 378977814 412 LDKTGSFNSVFTYFGICAAIGLVVILF 438
Cdd:cd17380 333 LEATGSWSLVFVLAAVVNLVGAVVFLL 359
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-439 |
1.14e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 107.66 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 19 FVVLTMIFLVYAInyadrtnIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAF 98
Cdd:cd17325 2 SLALFLDMLGYGI-------IIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 99 TWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFF 178
Cdd:cd17325 75 TLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 179 SFAIPGIVAAIAWYLLVKskpaesgfvsqselaeinagrESHNNSVRENILIAERFTWLDKIIRvkkmapidtakglftS 258
Cdd:cd17325 155 VCAALALLALVLALLLLP---------------------EPRPPPNKRAVSAARLRSGLRLLLR---------------D 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 259 KNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgrRRKPTMMFTAVST 338
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI---GRKPLILIGLLLS 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 339 VVMMLiMLNIPASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDkTGSF 418
Cdd:cd17325 276 AVALL-LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGF 353
|
410 420
....*....|....*....|.
gi 378977814 419 NSVFTYFGICAAIGLVVILFL 439
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLLL 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-439 |
6.72e-22 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 96.85 E-value: 6.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 13 RKTKYRFVVLTMIFLVYAINYAdrtNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSI 92
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 93 FGFSAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKA---TATGVYIAATMFAPIIVPpLAVWIAV 169
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASrlnLLHAFFSLGALLGPLLGG-LLILLGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 170 TWGWRWVFFSFAIPGIVAAIAWYLlvkskpaesgfvsqSELAEINAGRESHNNSVReniliaerftwldkiirvkkmapi 249
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLR--------------SKLPEIEEEEEEAAGSAA------------------------ 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 250 dTAKGLFTSKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMpcigGFIGAIGGGWVSDKLLGR-RRK 328
Cdd:COG0738 202 -SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL----FWGGMTIGRFLGGFLLKRfGPV 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 329 PTMMFTAVSTVVMMLIMLNIPASTLAVcIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGnLGGFVAPMAA 408
Cdd:COG0738 277 RLLRLSALLAAVGLLLALLAPGPWLAL-IGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLI 354
|
410 420 430
....*....|....*....|....*....|.
gi 378977814 409 GFLLDKTGsFNSVFTYFGICAAIGLVVILFL 439
Cdd:COG0738 355 GFLADAFG-LRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-439 |
8.92e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 96.08 E-value: 8.92e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 26 FLVYAINYAdrtnIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTV 105
Cdd:cd17324 9 FAIGTTEYV----IQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 106 SSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGI 185
Cdd:cd17324 85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 186 VAAIAWYLLVKSKPAESGFVSQSELAEinagreshnnsvreniliaerftwldkiirvkkmapidtaKGLFTSKNILGDC 265
Cdd:cd17324 165 LAALLLWRLLPSLPPKKPGSLGLLSSL----------------------------------------LLLLRNPRLRLAY 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 266 LAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKllgRRRKPTMMFTAVSTVVMMLIM 345
Cdd:cd17324 205 LITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR---GGRRALLIALLLLAAALLLLT 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 346 LnIPASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYpIASSIINSGGNLGGFVAPMAAGFLLDKTGsfnsvFTYF 425
Cdd:cd17324 282 L-LGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARG-LASSLYLAAYNLGGALGAALGGLVLDHGG-----WAGV 354
|
410
....*....|....
gi 378977814 426 GICAAIGLVVILFL 439
Cdd:cd17324 355 GWVGAALLLLALLL 368
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
18-364 |
8.38e-21 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 93.85 E-value: 8.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 18 RFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSA 97
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 98 FTWLMGTVSSV---FGLKLVRLGL-----GLSEGPCpvglASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAV 169
Cdd:cd17345 81 INILIGFVPSAtssVGLMFILLFLngwfqGMGWPPS----GRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 170 TWGWRWVFFSFAIPGIVA---AIAWYLLVKSKPAESGFVSQSELAEiNAGRESHNNSVRENILIAERFTwldkiirvkkm 246
Cdd:cd17345 157 IFGDGWWRGAFIFPAIIAiivAVIVLFLGKDTPESEGLPPIEEYKG-DYPEEADGEEEEQELSAWEIFV----------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 247 apidtaKGLFTSKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRR 326
Cdd:cd17345 225 ------KYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGR 298
|
330 340 350
....*....|....*....|....*....|....*...
gi 378977814 327 RKPTMMFTAVSTVVMMLIMLNIPaSTLAVCIGLFFVGF 364
Cdd:cd17345 299 RAPTGIIFMILVIVALIVYWLAP-NVLVDLIALIALGF 335
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
42-439 |
1.48e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 92.63 E-value: 1.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 42 VLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLS 121
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 122 EGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAvTWGWRWVFFSFAIPGIVAAIAWYLLVKSKPAE 201
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 202 SGFVSQSELaeinagreshnnsvreniliaerftwldkiirvKKMAPIDTAKGLFTSknILGDCLAYFmmvsVLYGLLTW 281
Cdd:cd17474 180 AKSSSATKL---------------------------------RDLKKALRGRGLLTF--LVSAFLYFF----LYFAFLTY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 282 IPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRkpTMMFTAVSTVVMMLIMLNIPASTLAVcIGLFF 361
Cdd:cd17474 221 LPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARR--ILVIGLLLYALSLLLLGFVPSLALLL-IAIVL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 378977814 362 VGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGsFNSVFTYFGICAAIGLVVILFL 439
Cdd:cd17474 298 FGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
22-419 |
3.05e-20 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 92.30 E-value: 3.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 22 LTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWL 101
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 102 MGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIA-VTWGWRWVFFSF 180
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 181 AIPGIVAAIAWYLLVKSKPaesgfvsqSELAEINAGRESHNNSVreniliaerftwldkiirvkkmapIDTAKGLFTSKN 260
Cdd:cd17328 161 GVLGVLLAILLLLFVREPP--------RGAAEGGVMAKSTATSF------------------------LADLKALAKNPS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 261 ILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVA----SMPCIGGFIGAIGGGWVSDKLLGRRRKPTMMFTAV 336
Cdd:cd17328 209 FILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGlifgAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAV 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 337 STVV---MMLIMLNIPASTLAVCIGLFFVG-FCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGN-LGGFVAPMAAGFL 411
Cdd:cd17328 289 GLLAaapFLFLALVLALSNLLLAWVLLFLGeFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLI 368
|
....*...
gi 378977814 412 LDKTGSFN 419
Cdd:cd17328 369 SDLLRQNK 376
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
58-438 |
3.13e-20 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 92.50 E-value: 3.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 58 GAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGL--GLSEGPCPVGLASTINN 135
Cdd:TIGR00894 79 GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRViqGLAQGSVSPATHKIIVK 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 136 WFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTW-GWRWVFFSFAIPGIVAAIAWYLLVKSKPAESGFVSQSELAEIN 214
Cdd:TIGR00894 159 WAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYIN 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 215 AGRESHNNSVRENILIAERFTWLDKIIrvkkmapidtakglftsknILGDCLAYFMMVSVlygLLTWIPLYLVKERGFDV 294
Cdd:TIGR00894 239 SSLQGQKGSTRQSLPIKAIPKSLPVWA-------------------IWFAIFGHFWLYTI---LPTYLPTFISWVLRVSG 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 295 MSMGFVASMPCIGGFIGAIGGGWVSDKLLGRR--RKPTMMFTAVSTVVMMLIMLNIPASTLAVCIGLFFVGFCLNIGWPA 372
Cdd:TIGR00894 297 KENGLLSSLPYLFAWLCSIFAGYLADFLKSSKtlSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSS 376
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 373 FTAYGMAVSDSKTYPIASSII----NSGGNLGGFVAPMAAGFLLdKTGSFNSVFTYFGICAAIGLVVILF 438
Cdd:TIGR00894 377 GPLAGVLINSLDLAPRFLGFIkgitGLPGFIGGLIASTLAGNIL-SQDSKNVWLIVFLIMAFVNILCVIF 445
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
49-438 |
4.53e-20 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 91.53 E-value: 4.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 49 EFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWL--MGTVSSVFGLKLVRLGLGLSEGPCP 126
Cdd:cd17318 50 EFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLtpLAARGGYGALIVLRILQGLAQGVTF 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 127 VGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLVksKPAESGFVS 206
Cdd:cd17318 130 PAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--LPVWAIVVA 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 207 QSelaeinagreSHNnsvreniliaerftWldkiirvkkmapidtakGLFTsknilgdclayfmmvsvlygLLTWIPLYL 286
Cdd:cd17318 208 HF----------GHN--------------W-----------------GFYT--------------------LLTELPTYM 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 287 VKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRKPTM----MFTAVSTVVMMLIMLNIPASTLAVCIGLFFv 362
Cdd:cd17318 227 SDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTtvrkLFTSIGFLGPGVFLIALGYLGSNATLAVVF- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 363 gFCLNIGWPAFTAYGMAVSDSKTYPIASSII----NSGGNLGGFVAPMAAGFLLDKTGSFNSVFTYFGICAAIGLVVILF 438
Cdd:cd17318 306 -LTLSVGLSGACYSGFLVNHLDLAPNYAGTLmgitNTAATIAGIISPLIVGAIVKNDQTIGQWRIVFFISAAIYILGAIF 384
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-442 |
3.64e-19 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 88.90 E-value: 3.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 26 FLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTV 105
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 106 SSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGV--------YIAATMFAPIIVPplavWIAVTWGWRWVF 177
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYvqsgwavgWLLATLLAALLFP----LLPPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 178 FSFAIPgivAAIAWYLlvkskpaeSGFVSQSELAEINAGRESHNnsvreniliaerftwldkiirvkkmAPIDTAKGLFt 257
Cdd:cd17371 161 LLGALP---ALLVLFI--------RRFVKEPPQWQAARAARRHF-------------------------ADRPSLRELF- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 258 SKNILGDCLAYFMMVSVL----YGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKlLGRRrkPTMMF 333
Cdd:cd17371 204 SPPLLRTTLLASLLATGAlggyYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR-IGRR--NNFAL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 334 TAVSTVVMMLIMLNIPASTLAVCIGLFFVGFCLNIGWPAFTAYGmavsdSKTYPI-----ASSIINSGGNLGGFVAPMAA 408
Cdd:cd17371 281 FALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYL-----TELFPTavratAQGFCYNVGRIIGALFPFLV 355
|
410 420 430
....*....|....*....|....*....|....
gi 378977814 409 GFLLDKTGSFNSVFTYFGICAAIGLVVILFLDEP 442
Cdd:cd17371 356 GFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-437 |
4.65e-18 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 84.96 E-value: 4.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 22 LTMIFLVYAINYADRTNIGAVLPFIIDEF--HINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFT 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 100 WLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWI----AVTWGWRW 175
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 176 VFFSFAIPGIVAAIAWYLLVkskpaesgfvsqselaeinagreshnnsvrenILIaerftwldkiirvkkmapidtakgl 255
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL--------------------------------LLI------------------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 256 ftsknilgdcLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgRRRKPTMMFTA 335
Cdd:cd17316 184 ----------LLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI--GRKKTLVIGLI 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 336 VSTVVMMLIMLNIPASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKT 415
Cdd:cd17316 252 LSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
|
410 420
....*....|....*....|..
gi 378977814 416 GSFNSVFTYFGICAAIGLVVIL 437
Cdd:cd17316 332 GGTGVPALILALLAIVALIVAL 353
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
18-439 |
5.70e-18 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 85.46 E-value: 5.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 18 RFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSA 97
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 98 FTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRwvf 177
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWR--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 178 FSFAIPGIVA---AIAWYLLVKSKPAESGFvsqselaeinagreshnnsvrENILIAErftwlDKIIRVKKMAPIDTAKG 254
Cdd:cd17343 158 STLSISGTVAvvmSVVCLLFIKNEPSDVGL---------------------NNIEEEE-----SKGKKKKSPRGESTLKE 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 255 LFTSKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRR-------- 326
Cdd:cd17343 212 LLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHgsssrgnp 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 327 RKPTMM-FTAVSTVVMMLIMLNIPASTLAVCIGL--FFVGFCLnigWPAFTAYGMAVSDSktYP-----IASSIINSGGN 398
Cdd:cd17343 292 RMPLALvFMAGLTVSLHLFRVHITSDSSELFILLlgFLIGFSL---YGPIAIFGVIANES--APshlcgTSHAIVALAAN 366
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 378977814 399 LGGFVAPMAAGfLLDKTGSFNSVFTYFgICAAIGLVVILFL 439
Cdd:cd17343 367 VGGVLAGLPFS-YIAKHYDWRTAFLLL-EILCAITVVILFL 405
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
22-439 |
3.87e-17 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 82.25 E-value: 3.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 22 LTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWL 101
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 102 MGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFA 181
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 182 IPGIVAAIAwyllvkskpaesgfvsqselaeinagreshnnsVRENILIAerftwldkiirvkkmapidtakglftskni 261
Cdd:cd17365 161 VPPLILLPL---------------------------------LRGTLLLW------------------------------ 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 262 lgdcLAYFMMVSVLYGLLTWIPlYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKllgRRRKPTMMFTAVSTVVM 341
Cdd:cd17365 178 ----VTFFMGLLLVYLLNSWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADR---FGPKRVLALFFALGAVS 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 342 MLIMLNIPASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNSV 421
Cdd:cd17365 250 LALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESV 329
|
410
....*....|....*...
gi 378977814 422 FTYFGICAAIGLVVILFL 439
Cdd:cd17365 330 FLALAIPAALGALAVLLL 347
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
16-405 |
1.59e-16 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 81.14 E-value: 1.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 16 KYRFVVLTMIFLVYAINYADRTNIG--AVLPFIIDeFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIF 93
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISnaAVMGMKED-LKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 94 GFSAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVT--- 170
Cdd:cd17327 80 LWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 171 ---WGWRWVFFSFAIPGIVAAIAWYLLVKSKPAESGFVSQSElaeinagRESHNNSVREN--ILIAERFTWLDkiirvkk 245
Cdd:cd17327 160 gglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEE-------KELAVERLRANqtGKGDQKFKWKQ------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 246 mapidtAKGLFTSKNILGDCLAYFMMVSVLYGLLTWIPLyLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgR 325
Cdd:cd17327 226 ------IKEAFKDPRTWLLFLFFFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRF--K 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 326 RRKPTMMFTAVSTVVMMLIMLNIPASTLAVcIGLFFVGFCLNIGWP-AFTAYGMAVSDSKTYPIASSIINSGGNLGGFVA 404
Cdd:cd17327 297 KRGLFAIFACVLALVGSIILLAAPNPPGAY-FAAYILGGGSYAGFPiLLSWISSNCAGYTKRATVLAIMLIFYNVGNIVA 375
|
.
gi 378977814 405 P 405
Cdd:cd17327 376 P 376
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
20-439 |
2.21e-16 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 80.39 E-value: 2.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 20 VVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFT 99
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 100 WLMGTVSSVFGLKLVRLGL-GLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFF 178
Cdd:cd17355 83 VLLALATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 179 SFAIPGIVAAIAWYLLVKSKPAESGFVSQSELAEInagreshnnsvreniliaerftwldkiirvkkmAPIDTAKGLFTS 258
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPA---------------------------------SPGSTLKEALRS 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 259 KNILGDCLAYFMMVSVLYGLLTWIPLYLVkERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRKPTMMFtavST 338
Cdd:cd17355 210 ASFWLLALAFFLCGFAVVGLIVHLVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYA---LR 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 339 VVMMLIMLNIPASTLAVCIGLFFVGFClNIGWPAFTAYGMAVS-DSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGS 417
Cdd:cd17355 286 ALGLALLLLLPFPPLALLLFAALFGLG-WGATVPLTAALAARYfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGS 364
|
410 420
....*....|....*....|..
gi 378977814 418 FNSVFTYFGICAAIGLVVILFL 439
Cdd:cd17355 365 YTAAWALAVALGLIAALLVLPI 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-200 |
1.24e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 77.16 E-value: 1.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 10 TDARKTKYRFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVS 89
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 90 LSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAV 169
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190
....*....|....*....|....*....|.
gi 378977814 170 TWGWRWVFFSFAIPGIVAAIAWYLLVKSKPA 200
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRLPESRGL 194
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
22-438 |
2.07e-14 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 74.60 E-value: 2.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 22 LTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFT-W 100
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLlA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 101 LMGTVSSVFGLKLVRLGLGLSEGPCPVGLAStINNWFPPKEKATATGVYIAATM----FAPIIVPPLAVWIAVTW---GW 173
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPW-ASFWFPKEKIGGAAGGIAGAGNmgvaVSQLLAPLIAGAIVFDGgfvGW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 174 RWVFFSFAIPGIVAAIAWYLLVKSKPAESGFVSQSELAEINAGRESHnnsvreniliaerfTWldkiirvkkmapidtak 253
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVLKNYR--------------TW----------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 254 glftsknILgdCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRKPTMMF 333
Cdd:cd17341 209 -------IL--SLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFI 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 334 TAVSTVVMMLIMLNIPASTLAVCIGLFFV-GFCLNIGWPAFTAYGMAVSDSKTyPIASSIINSGGNLGGFVAPMAAGFLL 412
Cdd:cd17341 280 VMTIGAALLSLSLPTSGTNLVLFLALFVAlGLGAGAGNGSVFRMVPFIFRREL-GAVTGLVGAIGGLGGFFLPLLFGSSA 358
|
410 420
....*....|....*....|....*.
gi 378977814 413 DKTGSFNSVFTYFGICAAIGLVVILF 438
Cdd:cd17341 359 LMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
10-412 |
6.28e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.16 E-value: 6.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 10 TDARKTKYRFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVS 89
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 90 LSIFGFSAFTWLMGTVSSVFGLKLVRL--GLGLSeGPCPVGLASTINNWfPPKEKATATGVYIAATMFAPIIVPPLAVWI 167
Cdd:TIGR00895 87 WSILLFSVFTLLCALATNVTQLLILRFlaGLGLG-GLMPNLNALVSEYA-PKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 168 AVTWGWRWVffsFAIPGIVAAIAWYLLVKSKPaESGFVSQSELAEinAGRESHNNSVRENILIAERFTWLDKIIRVKKMA 247
Cdd:TIGR00895 165 IPVFGWRSL---FYVGGIAPLLLLLLLMRFLP-ESIDFLVSKRPE--TVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 248 PIDTAKGLFTSKNILGDCLAYFMMVSVLYGLLTWIPlYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgrRR 327
Cdd:TIGR00895 239 VFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL---GP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 328 KPTMMFTAVSTVVMMLIMLNIPASTLAVCIGlFFVGFCLNIGWPAFTAYgMAvsdsKTYPIASSIINSG-----GNLGGF 402
Cdd:TIGR00895 315 RVTALLLLLGAVFAVLVGSTLFSPTLLLLLG-AIAGFFVNGGQSGLYAL-MA----LFYPTAIRATGVGwaigiGRLGAI 388
|
410
....*....|
gi 378977814 403 VAPMAAGFLL 412
Cdd:TIGR00895 389 IGPILAGYLL 398
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
41-439 |
6.87e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 72.63 E-value: 6.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 41 AVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGL 120
Cdd:cd17489 17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 121 SEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFsfaIPGIVAAIAWYLLvkskpa 200
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFI---VAAVLALLALLLV------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 201 esgfvsqselaeinagreshnnsvreniliaeRFTWLDKIIRVKKMAPIDTAKGLFTSKNILGDCLAYFMMVSVLYGLLT 280
Cdd:cd17489 168 --------------------------------FLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIST 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 281 WIPLYlVKERGFDVMSMGFVASmpCIGGFIGAIGGGWVSDKllgRRRKPTMMFTAVSTVVMMLIMLNIPASTLAVcIGLF 360
Cdd:cd17489 216 FLPLY-AAERGISNAGLFFTVY--AIALLLSRPFSGKLSDR---KGPKTVIIPGLLLLALGLLLLSFAGSPWMLL-LAAV 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 378977814 361 FVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGsFNSVFTYFGICAAIGLVVILFL 439
Cdd:cd17489 289 LYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFL 366
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
35-202 |
1.45e-12 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 69.33 E-value: 1.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 35 DRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLV 114
Cdd:TIGR00711 17 DSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 115 RLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGI-VAAIAWYL 193
Cdd:TIGR00711 97 RVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIiVVVVAFFI 176
|
....*....
gi 378977814 194 LVKSKPAES 202
Cdd:TIGR00711 177 LPRDKPAAS 185
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
39-439 |
1.69e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 1.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHINN-FEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLG 117
Cdd:cd17473 18 IAPALPAIAQHFVPNSeLLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRAL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 118 LGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAvTWGWRWVFFSFAIPGIVAAIAWYLLVKS 197
Cdd:cd17473 98 LGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLFLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 198 KPAesgfvsqselaeinagreshnnsvreniliaerftwldkiiRVKKMAPIDTAKGLFTSKNILGDCLAYFMMVSVLYG 277
Cdd:cd17473 177 ARK-----------------------------------------SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 278 LLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGgwvsDKLLGRRRKPTMMFTAVSTVVMMLIMLNIPASTLAVCI 357
Cdd:cd17473 216 IPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLF----GRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 358 GLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNSVFTYFGICAAIGLVVIL 437
Cdd:cd17473 292 GAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
..
gi 378977814 438 FL 439
Cdd:cd17473 372 LL 373
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
62-196 |
2.41e-12 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 64.21 E-value: 2.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 62 SMFFLGYAVSQI----PAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWF 137
Cdd:TIGR00880 1 GLLLAGYALGQLiyspLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 378977814 138 PPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLVK 196
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
43-401 |
5.82e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 66.83 E-value: 5.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 43 LPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSE 122
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 123 GPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIawyllvkskpaes 202
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALL------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 203 gfvsqselaeinagreshnnsvreniliaerftwLDKIIRVKkmapidtakgLFTSKNILGDCLAYFMMVSVLYGLLTWI 282
Cdd:cd17503 166 ----------------------------------LAPLLDLR----------LFKDRNFTLGLLLSFLLGLGLFGAMFLL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 283 PLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRR-KPTMMFTAVSTVVMMLIMLNIPASTLAVCigLFF 361
Cdd:cd17503 202 PLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLlLAGLLLLALGTLLLAFLTPDTSLWLIILP--LFI 279
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 378977814 362 VGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGG 401
Cdd:cd17503 280 RGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGG 319
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
40-439 |
7.42e-12 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 66.48 E-value: 7.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 40 GAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGL- 118
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLg 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 119 GLSEGPCPVGLASTINNWFPPKeKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSF-AIPGIVAAIAWYLLvkS 197
Cdd:cd17353 103 GIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILgIIFLIIIVIGAFLI--R 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 198 KPAESGFVSQSELAEINAGRESHNNSVRENILIAErfTWLdkiirvkkmapidtakgLFtsknilgdcLAYFMMVSVLYG 277
Cdd:cd17353 180 DPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPT--FWL-----------------LW---------LMFFLNATAGLM 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 278 LLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKlLGRRRkpTMMFTAVSTVVMMLIMLNIPASTLAVCI 357
Cdd:cd17353 232 LIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK-IGRKN--TLSIAFLIQGVAMFLLPFIGSVAVLFVL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 358 GLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFlLDKTGSFNSVFTYFGICAAIGLVVIL 437
Cdd:cd17353 309 GVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAAALSLVALALAL 387
|
..
gi 378977814 438 FL 439
Cdd:cd17353 388 LL 389
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
43-439 |
7.24e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 63.36 E-value: 7.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 43 LPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSE 122
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 123 GPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIA-WYLLVKSKPAE 201
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLvLLFLPETLPEE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 202 SGFVSQSELAEInagreshnnsvreniliaerftwldkiirvkkmapidtAKGLFTSKNILGDCLAYFMMVSVLYGLLTW 281
Cdd:cd17320 182 KRKPLLSSLLRA--------------------------------------YKRVLKNRRFLGYALALGLSFAGLFAYLAA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 282 IPLYLVKERGFDVMSMGFVASMPciggFIGAIGGGWVSDKLLGRRRKPTMM-----FTAVSTVVMMLIMLNIPASTLAVC 356
Cdd:cd17320 224 APFIYIEQLGLSPAQFGLLFALN----AIALILGSLLNGRLVRRFGPRRLLrlgllLLLAAALVLLLAALLGGLSLWPLV 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 357 IGLFFVGFCLNIGWPAFTAYGMAVSDSKTyPIASSIINSGGNLGGFVAPMAAGFLLDktGSFNSVFTYFGICAAIGLVVI 436
Cdd:cd17320 300 APLFLIFFGFGLIFPNATSLALEPFPHVA-GTASALLGFLQFLIGALAGALVGLLPN--GTALPMGLLILVLGLLALLLL 376
|
...
gi 378977814 437 LFL 439
Cdd:cd17320 377 ILL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-196 |
1.10e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 62.97 E-value: 1.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 19 FVVLTMIFLVYAINYADRTNIGAVLP-FIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRG--LVSLSIFGF 95
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPtYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 96 SAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRW 175
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 378977814 176 VFFSFAIPGIVAAIAWYLLVK 196
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
58-195 |
1.60e-10 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 62.49 E-value: 1.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 58 GAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTwLMGTVSSVFG---LKLVRLGLGLSEGPCPVGLASTIN 134
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFT-LLTPLAADLGagyLIAVRALEGLGEGVTFPAMHAMWA 146
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378977814 135 NWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLV 195
Cdd:cd17381 147 SWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV 207
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-195 |
9.39e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 9.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 24 MIFLVYAINYADRTNIGAVLP-FIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLM 102
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 103 GTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAI 182
Cdd:cd17325 283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
|
170
....*....|...
gi 378977814 183 PGIVAAIAWYLLV 195
Cdd:cd17325 363 LLLLAAVLFLLLR 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
41-437 |
2.58e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.72 E-value: 2.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 41 AVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGL 120
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 121 SEG---PcpvgLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLVKS 197
Cdd:cd17478 97 GSAafhP----EGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 198 KPAESGfvsqselaeiNAGRESHNNSVRENILIAERFTWLDKIIRVkkmapidtakglftsknilgdclayfmmvSVLYG 277
Cdd:cd17478 173 KKPEAK----------KAAAKSSARSTLKGVWRALLLLLIIVFLRS-----------------------------WVLSS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 278 LLTWIPLYLVkERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgrRRKPTMMFTAVSTVVMMLIMLNipASTLAVCI 357
Cdd:cd17478 214 LTTFLPFYLV-QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF---GRRRVIIASLLLAAPFLLLFLL--TPGIWSYI 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 358 GLFFVGFCLNIGWPAFTAYGMAVSDSKTyPIASSIINSGGNLGGFVAPMAAGFLLDKTGsFNSVFTYFGICAAIGLVVIL 437
Cdd:cd17478 288 LLVLAGFLLFASFPVTVVLAQELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLGALLAF 365
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
39-195 |
2.80e-09 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 58.74 E-value: 2.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGL 118
Cdd:cd17323 18 YSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQ 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378977814 119 GLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLV 195
Cdd:cd17323 98 GFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFL 174
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
39-439 |
3.99e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.95 E-value: 3.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGL 118
Cdd:cd17477 15 LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 119 GLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFApIIVPPLAVWIAVTWGWRWVFFSFAIpgIVAAIAWYLLVKSK 198
Cdd:cd17477 95 GIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLG-FALGPLLLALVGTAGALPFLIAAVL--LLLALVPLLLTRRA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 199 PAESgfvsqselaeinagreshnnsvreniliaerftwldkiirvKKMAPIDTAKGLFTSKNILGDCLAYFMMVSVLYGL 278
Cdd:cd17477 172 APEI-----------------------------------------EEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 279 LtwiPLYLVkERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlGRRRkpTMMFTAVSTVVMMLIMLNIPASTLAVCIG 358
Cdd:cd17477 211 L---PLYGL-RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRF-DRRR--VLLGCALLGALAALLLPLVPGLPLALLVL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 359 LFFVGFClnigwpAFTAYGMAVS------DSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNsvftYFGICAAIG 432
Cdd:cd17477 284 LFLWGGA------AGPLYTLALAlagdrlPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHG----LFLFLAAVA 353
|
....*..
gi 378977814 433 LVVILFL 439
Cdd:cd17477 354 LLFLLFL 360
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
11-364 |
4.01e-09 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 58.18 E-value: 4.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 11 DARKTKYRFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTR----- 85
Cdd:PRK11663 14 DARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARyfmgi 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 86 GLVSLSI----FGFSAFTWLMGTVssvFGLKLVRLGLGLSegPCpvglASTINNWFPPKEKATATGVYIAATMFAPIIVP 161
Cdd:PRK11663 94 GLIATGIinilFGFSSSLWAFALL---WVLNAFFQGWGWP--VC----AKLLTAWYSRTERGGWWAIWNTAHNVGGALIP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 162 PLAVWIAVTWGWRwvfFSFAIPGIVAAIAWYLL---VKSKPAESGFVS-------QSELAEINAGRESHNNSVRENILIA 231
Cdd:PRK11663 165 LVVGAIALHYGWR---YGMMIAGIIAIVVGLFLcwrLRDKPQAMGLPSvgewrhdALELAQQQEGAGLSRKEILTKYVLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 232 ERFTWLDkiirvkkmapidtakglftsknilgdCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIG 311
Cdd:PRK11663 242 NPYIWLL--------------------------SFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIG 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 378977814 312 AIGGGWVSDKLLGRRRKPTMMFTAVSTVVMMLIMLNIPASTLAVCIGLFF-VGF 364
Cdd:PRK11663 296 ALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQAACFFtIGF 349
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
49-194 |
5.23e-09 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 57.73 E-value: 5.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 49 EFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFG--LKLVRLGLGLSEG--- 123
Cdd:cd17382 43 EFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYgcVIFVRILQGLVEGvty 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378977814 124 PCPVGLAStinNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLL 194
Cdd:cd17382 123 PACHGIWR---KWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV 190
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
39-439 |
1.20e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.41 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGL 118
Cdd:cd17321 15 VNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 119 GLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAaiawyllvksk 198
Cdd:cd17321 95 GIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA----------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 199 paesgfvsqselaeinagreshnnsvreniliaerftwldkiirvkkmapidtakgLFTSKNILGDCLAYFMMVSVLYGL 278
Cdd:cd17321 164 --------------------------------------------------------LLLARTFSGAVLAAFLLGAALGGL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 279 LTWIPLYLVKERGFDVMSMGFvASMPcigGFIGAIGGGWVSDKLLGRR--RKPTMMFTAVSTVVMMLI-MLNIPASTLAV 355
Cdd:cd17321 188 LFLLPLYLQGVLGYSPLQAGL-ALLP---LALAMLVAAPLAGRLADRFgpRLVLVAGLLLTAVGLLLLaLLGADSSVWLL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 356 CIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLL----------------------D 413
Cdd:cd17321 264 LPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLtaglsanlgdsgvaallsaaaaA 343
|
410 420
....*....|....*....|....*.
gi 378977814 414 KTGSFNSVFTYFGICAAIGLVVILFL 439
Cdd:cd17321 344 FAAGFHLAFLVAAALALLAALLALLL 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
265-442 |
1.43e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 56.27 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 265 CLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgrRRKPTMMFTAVSTVVMMLI 344
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---GRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 345 MLnIPASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGsFNSVFTY 424
Cdd:pfam07690 79 LL-FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....*...
gi 378977814 425 FGICAAIGLVVILFLDEP 442
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPP 174
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
25-438 |
1.07e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 25 IFLVYAINYAdrtNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGT 104
Cdd:cd17333 4 SFFSNGLTDA---LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 105 VSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKAT---ATGVYIAATMFAPIIVPPLaVWIAVTWGW-RWVFFSF 180
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRlnvLHGFFGLGALIGPLIATSL-LTSELSWSWaYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 181 AIPGIVAAiawyLLVKSKPaesgfvsqselaeinagRESHNNSVRENILIAErftwldkiirvkkmapidTAKGLFTSKN 260
Cdd:cd17333 160 YLLLAILI----LLTLFPE-----------------LPSARNPQQSVGAFSA------------------SASRLLRNPS 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 261 ILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRrrkpTMMFTAVSTVV 340
Cdd:cd17333 201 IILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPH----TLLVLSGSGAL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 341 MMLIMLNIPASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTyPIASSIINSGGNLGGFVAPMAAGFLLDkTGSFNS 420
Cdd:cd17333 277 LGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAE-AVGIQT 354
|
410
....*....|....*...
gi 378977814 421 VFTYFGICAAIGLVVILF 438
Cdd:cd17333 355 AMLLITILYAIIFVLALL 372
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
18-187 |
1.67e-07 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 53.18 E-value: 1.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 18 RFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSA 97
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 98 FTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVF 177
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170
....*....|
gi 378977814 178 FsfaIPGIVA 187
Cdd:cd17488 161 Y---VPGIIA 167
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-194 |
2.27e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.62 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 17 YRFVVLTMIFLVYAINYADRTNIGAVLPFIIDE-FHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGF 95
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 96 SAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRW 175
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*....
gi 378977814 176 VFFSFAIPGIVAAIAWYLL 194
Cdd:cd06173 365 VFLLAGALLLLAALLLLLL 383
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
37-439 |
2.28e-07 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 37 TNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWL--MGTVSSVFGLKLV 114
Cdd:cd17339 16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLrsLGGIALLFLGTAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 115 rLGLGLSEGPcpVGLASTINNWFPPKeKATATGVYIAATMFAPIIVPPLAVWIAVT--WGWRWVFFSFAIPGIVAAIAWY 192
Cdd:cd17339 96 -AGAGIAVGN--VLLPSLIKRDFPRR-VGLMTGLYTTSMNLGAALASGLSVPLAQAlgGGWRGALAIWALPALLALLIWL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 193 LLVKSKPAESgfvsqselaeinagreshnnsvreniliaerftwldkiirvkkmapidTAKGLFTSKNILGDCLAYFMMV 272
Cdd:cd17339 172 PQLRRRKRAA------------------------------------------------AAAAPLTKISVWRSPLAWQVTL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 273 ------SVLYGLLTWIPLYLVkERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRrkPTMMFTAVSTVVMMLIML 346
Cdd:cd17339 204 fmglqsLLFYTLMAWLPTILI-DAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQR--PIVVLLAVLFIIGVLGLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 347 NIPASTLAVCIGLFFVG----FCLnigwpAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNSVF 422
Cdd:cd17339 281 FAPTALALLWAVLLGLGggaaFSL-----ALTLISLRSSDPAEAAALSGMAQSVGYLLAALGPLLFGVLHDLTGSWTAPL 355
|
410
....*....|....*..
gi 378977814 423 tYFGICAAIGLVVILFL 439
Cdd:cd17339 356 -VLLLALTVLQLVAGLG 371
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
25-438 |
2.72e-07 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 52.74 E-value: 2.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 25 IFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVS----LSIFGFSAFTW 100
Cdd:PRK09556 34 VFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPflliLSAICMLGFGA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 101 LMGTVSSVFGLKLVRLGL-GLSE---GPCPVglaSTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWV 176
Cdd:PRK09556 114 SLGSGSVSLGLMIALWALsGFFQstgGPCSY---STITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 177 FFSFAIPGIVAAIA--WYLLV-KSKPAESGFVSQSELAEINAGREshnNSVRENILIAERFTWLDKIIRvkkmapidtak 253
Cdd:PRK09556 191 IGMFIFPSIIALIIgfIGLRYgSDSPEELGWGKAEEIFGEPISEE---DKETESTDMTKWQIFVEYVLK----------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 254 glftSKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRrkptmMF 333
Cdd:PRK09556 257 ----NPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRR-----AL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 334 TAVSTVVMMLIMLNIPA---STLAVCIGLFFVGFC-----LNIGWPAF-------TAYGMAVSDSKTYPIASSIINSGgn 398
Cdd:PRK09556 328 VACIALALIIFTLGVYQhatSEYMYLASLFALGFLvfgpqLLIGVAAVgfvpkkaIGVANGIKGTFAYLFGDSFAKVG-- 405
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 378977814 399 LGGFVAPMAAG---FLLDKTGsFNSVFTYFGICAAIGLVVILF 438
Cdd:PRK09556 406 LGMIADPTKNGtpiFGYTLTG-WAGTFAALDIAAIGCICLMAI 447
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
38-401 |
5.41e-07 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 51.53 E-value: 5.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 38 NIGAVLPFII-DEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTV-SSVFGLKLVR 115
Cdd:TIGR00886 19 AFSPLAVFLIkDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 116 LGLGLSEGPCPVGLAStINNWFPPKEKATATGVYIAA----TMFAPIIVPPLAVWIA--------VTWGWRWVFFSFAIP 183
Cdd:TIGR00886 99 LFIGIAGGSFASCMPW-ISFFFPKKIQGTALGLAAGWgnmgGGVAQFVMPPIIGSLIfgggqpahLAWGWAFVIVPAGIL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 184 -----GIVAAIAWYLLVKSKPAESGFVSQSELAEinagreshnnsvreniliaERFTWLDkiirvkkmapidtakglfts 258
Cdd:TIGR00886 178 llpalLIFFVGADTPPGKPATGKLSFKEALKVFG-------------------NRHTWIL-------------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 259 knilgdCLAYFMMVSVLYGLLTWIPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKlLGRRRKPTMMFTAVST 338
Cdd:TIGR00886 219 ------ALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDR-LGGARKLLMNFLGVAM 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378977814 339 VVMMLIMLNIPASTLAVCIGLfFVGFCLNIGWPAFTAYGM-AVSDSKTYPIASSIINSGGNLGG 401
Cdd:TIGR00886 292 GAFLVVLGLVSDGSLAAFIVL-FVALFFFAGAGNGSTFALvPHIFRRATGAVSGLIGAIGNLGG 354
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
18-438 |
3.15e-06 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 48.95 E-value: 3.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 18 RFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSA 97
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 98 FTWLMGTV-SSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKeKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWV 176
Cdd:cd17314 81 GYTYLSYVfNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 177 ffsFAIPGIVAAIAWYLLVKSKPAEsgfvSQSELAEINAGRESHNNSVRENIliaerftwlDKIIRVKKMAPIDTAKGLF 256
Cdd:cd17314 160 ---YTILGILAAIVLSVVSLLGFKE----PPDNQARLHVQKKKTQTMGEIFR---------DKVFWILFIAIFLVLIGGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 257 TsknilgdclayFMMVSVLYGlltwiPLYLVKERGFDVMSMGFVASMpcigGFIGAIGGGWVSDKLLGR-RRKPTMMFTA 335
Cdd:cd17314 224 L-----------FIANMASLV-----RSLQLDAPSFVTKLMSIYGLF----NAFGRLLWGIVADFFGGRlSTLSILLTIL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 336 VSTVVMMLIMLNIPASTLAVCIGLFFVGFClniGWPAFTaygmAVSDSKTYPIAS-----SIINSGGNLGGFVAPMAAGF 410
Cdd:cd17314 284 GLGLCAFLFLLKMTPVGLVLTGSLLGFSYG---GLFTVY----PATVSTVFGTESfatlyGILLFAPAIGSILGPMLGAK 356
|
410 420
....*....|....*....|....*...
gi 378977814 411 LLDKTGSFNSVFTYFGICAAIGLVVILF 438
Cdd:cd17314 357 FYDRTPSYISAVYIYAVIVFLASAILLA 384
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
19-439 |
3.16e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 49.09 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 19 FVVLTMIFLVYAINYAdrtnIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTR------GLVSLSI 92
Cdd:cd17352 6 FASFLVNFFTDGILNS----FGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRpvaiagGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 93 FGFSAFTWLMGTVSSVFGLkLVRLGLGLSEGPCpvglASTINNWFPpKEKATATGVYIAATMFAPIIVPPLAVWIAVTWG 172
Cdd:cd17352 82 LLLSSFATSLWQLYLTYGV-LGGLGLGLIYSPA----IVIVGQYFE-KKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 173 WRWVFFSFAIPGIVAAIAWYLLVkskpaesgfvsqselaeinagreshnnsvreniliaerftwldkiirvkkmapidta 252
Cdd:cd17352 156 WRGALLILGGLCLNLCVCGLLLR--------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 253 kgLFTSKNILGDCLAYFMMVSVLYGLLTWIPLYLvKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKllGRRRKPTMM 332
Cdd:cd17352 179 --LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADK--PRIGRLYLY 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 333 FTAVSTVVMMLIMLNIPASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLL 412
Cdd:cd17352 254 IFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLR 333
|
410 420
....*....|....*....|....*..
gi 378977814 413 DKTGSFNSVFTYFGICAAIGLVVILFL 439
Cdd:cd17352 334 DYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
21-209 |
9.15e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 47.68 E-value: 9.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 21 VLTMIFLVYAINYAdRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTW 100
Cdd:cd06180 1 LAGALALAVAMGIG-RFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 101 LMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFApIIVPPLAVWIAVT--WGWRWVFF 178
Cdd:cd06180 80 AMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLG-IALSGLLVPAGLGggLSWRAGWL 158
|
170 180 190
....*....|....*....|....*....|.
gi 378977814 179 SFAIPGIVAAIAWYLLVKSKPAESGFVSQSE 209
Cdd:cd06180 159 ALALLSAVLLLLSFLLLRRGPSAPTEASAAE 189
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-190 |
1.51e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.80 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 41 AVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGL 120
Cdd:cd17504 17 PALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 121 SEGPCPVGLAsTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIA 190
Cdd:cd17504 97 GGAVFPLAFA-LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
282-439 |
1.88e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.45 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 282 IPLYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgrRRKPTMMFTAVSTVVMMLIMLnIPASTLAVCIGLFF 361
Cdd:cd17329 22 MAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRF---GRKPVMLAGLLLRALGFALLG-FAHSPWLFAIALVL 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 378977814 362 VGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDktGSFNSVFTYFGICAAIGLVVILFL 439
Cdd:cd17329 98 TGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL--YSFRLLFLAAAVLFLLAALVLLFL 173
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
45-201 |
2.93e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 2.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 45 FIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLV----SLSIFGFSAFTWLMGTVSSVFGLKLVrlGLGL 120
Cdd:COG0738 236 YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLrlsaLLAAVGLLLALLAPGPWLALIGLALV--GLGL 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 121 SeGPCPVGLASTINNwfPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLVKSKPA 200
Cdd:COG0738 314 S-LMFPTIFSLALDG--LGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
.
gi 378977814 201 E 201
Cdd:COG0738 391 K 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
265-439 |
3.16e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 265 CLAYFMMVSVLYGLLTWIPLyLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgrRRKPTMMFTAVSTVVMMLI 344
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF---GRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 345 MLNIPaSTLAVCIGLFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGsFNSVFTY 424
Cdd:COG2814 92 CALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLV 169
|
170
....*....|....*
gi 378977814 425 FGICAAIGLVVILFL 439
Cdd:COG2814 170 NAVLALLALLLLLRL 184
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
242-438 |
4.97e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.21 E-value: 4.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 242 RVKKMAPIDTAKGLftSKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGFD---VMSMGFVASMpciGGFIGAIGGGWV 318
Cdd:cd17369 213 QVVRAPLVEVLRRH--WRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDrstVLLAVLIASV---VAAITIPLFGWL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 319 SDKLlGRRrkPTMMFTAVSTVV-----MMLIMLNIPASTLAVCIGLFFVGFCLNIG-WPAFTA--------Y-GMAVSds 383
Cdd:cd17369 288 SDRV-GRR--PVYLAGALLAALfafpfFWLLDTGSTWLIVLAAVVVLGVLHGMMYGpQAAFLAelfptrvrYtGASLG-- 362
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 378977814 384 ktypiassiINSGGNLGGFVAPMAAGFLLDKTGSFNSVFTYFGICAAIGLVVILF 438
Cdd:cd17369 363 ---------YQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
317-439 |
5.43e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 317 WVSDKLLGR--RRKPTMMFTAVSTVVMMLIMLNIP-----ASTLAVCIGLFFVGFCLNIGWPAFTAYGMAVS-DSKTYPI 388
Cdd:COG2211 68 ALSDRTRTRwgRRRPWILIGAIPLALSFVLLFTAPdlsptGKLIYALVTYLLLGLAYTLVNIPYSALGAELTpDYEERTR 147
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 378977814 389 ASSIINSGGNLGGFVAPMAAGFLLDKTG--SFNSVFTYFGICAAIGLVVILFL 439
Cdd:COG2211 148 LSSWRFAFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLT 200
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
265-442 |
9.54e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.49 E-value: 9.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 265 CLAYFMMVSVLYGLLTWIPLYlVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgRRRKPTMMFTAVSTVVMMLI 344
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRF--GRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 345 MLnipASTLAVCIGL-FFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGsFNSVFT 423
Cdd:cd17325 79 AF---ATSYWQLLLArFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFL 154
|
170
....*....|....*....
gi 378977814 424 YFGICAAIGLVVILFLDEP 442
Cdd:cd17325 155 VCAALALLALVLALLLLPE 173
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
10-168 |
1.48e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.85 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 10 TDARKTKYRFVVLTMIFLVYAINYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVS 89
Cdd:cd17333 190 ASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLV 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 90 LSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSEGPC-PVGLASTINNWfpPKEKATATGVYIAATMFAPIIVPPLAVWIA 168
Cdd:cd17333 270 LSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALfPTILSLGISNL--PYAKGKGTSVLLAAGSIGGAIIPFIMGFIA 347
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
44-191 |
1.54e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 43.75 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 44 PFIIDEFHINNFEAGAIASMFFLGYAVSQ-IPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSE 122
Cdd:cd17331 232 LVAMDFFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGG 311
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 123 GPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWV-FFSFAIPGIVAAIAW 191
Cdd:cd17331 312 SVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFgLLGAAINGLLTVYLL 381
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
39-199 |
2.09e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 43.33 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHI--NNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSV----FGLK 112
Cdd:cd17315 16 INGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVwvliVGRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 113 LVRLGLGLSEGPCPVGLASTInnwfPPKEKATATGVY----IAATMFAPIIVPPLAVWIavTWGWRWVFFSFAIPGIVAA 188
Cdd:cd17315 96 LLGLGVGLASVLVPLYISEIA----PAKIRGALGTLNqlmiTFGILLAYLLGLALSLSP--PGWWRLMFALAAVPALLQL 169
|
170
....*....|.
gi 378977814 189 IAWYLLVKSKP 199
Cdd:cd17315 170 LLMFFLPESRA 180
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
317-439 |
2.99e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 42.98 E-value: 2.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 317 WVSDKllGRRRKPTMMFTAVSTVVMMLIM-----LNIPASTLAVCIGLFFVGFCLNIGW-PAFTA-------YGMAVSDS 383
Cdd:cd17385 258 WLSDK--KKIPKWLMVIGSIITGVGFLLLgpaplLPIKSELWMVIIGLVLLGLSLGAALvPTFPEllncareYGFPDNLS 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 378977814 384 kTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNSVFTYFGICAAIGLVVILFL 439
Cdd:cd17385 336 -TYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
39-202 |
4.02e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.56 E-value: 4.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTR----GLVSLSIFGFSAFTWLMGTVSSVFGLKLV 114
Cdd:COG2223 225 SSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRrvllIVFALMALGLLLLALALGSLWLFLVLFLL 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 115 rlgLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLA-VWIAVTWGWRWVFFSFAIPGIVAAIAWYL 193
Cdd:COG2223 305 ---LGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFgALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
....*....
gi 378977814 194 LVKSKPAES 202
Cdd:COG2223 382 LYRRPRRAA 390
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
39-193 |
4.29e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 42.38 E-value: 4.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRL-- 116
Cdd:PRK03893 39 ITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLvi 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378977814 117 GLGLSeGPCPVGLASTINNWfPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPgivAAIAWYL 193
Cdd:PRK03893 119 GMGMA-GEYGSSATYVIESW-PKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILP---IIFALWL 190
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
265-442 |
4.35e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.18 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 265 CLAYFMMVSVLYGLLTWIPlYLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRrkpTMMFTAVSTVVMMLI 344
Cdd:COG2223 11 TLAFFLAFGVWYLWSVLAP-PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 345 MLNIPASTLAVCIGlFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNSVFTY 424
Cdd:COG2223 87 LALAVSYWLLLLLG-LLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170
....*....|....*...
gi 378977814 425 FGICAAIGLVVILFLDEP 442
Cdd:COG2223 166 GILLLVVAVLAWLFLRDP 183
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
43-196 |
6.65e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.60 E-value: 6.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 43 LPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSE 122
Cdd:TIGR00710 28 FPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGA 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378977814 123 GPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLVK 196
Cdd:TIGR00710 108 SAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP 181
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
37-438 |
8.54e-04 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 41.44 E-value: 8.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 37 TNIGAVL-PFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRG--LVSLSIFGFSAFTWLMGTVSSVFGLKL 113
Cdd:cd17394 15 TNLNDILiPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKgiLLGLGLYAIGALLFIPAASLRTYGLFL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 114 VRLGLglsegpcpvglastinnwfppkekaTATGVYIAATMFAP---IIVPP--LAVWIAVTWgwrwVFFSFAipGIVAA 188
Cdd:cd17394 95 IALFV-------------------------LASGLALLQTAANPyvtVLGPEetAARRLNLAQ----AFNSLG--STIAP 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 189 -IAWYLLVKSKPAESGFVSQSELAEINAGRESHNNSVREN-------ILIAERFTWLDKIIRVKKMAPI-----DTAKGL 255
Cdd:cd17394 144 lFGSYLILSGIPSTATALAAMSAAELQAYKTAELASVQLPylgialvLLLLAVLILLSKLPEIEAAEAEalgskGTLLRL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 256 FTSKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGF-------DVMSMGFVASMPCIggfigaigggWVSDKLLGRRRK 328
Cdd:cd17394 224 LKNPHLRLGVLAIFFYVGAEVAIWSFLINYLMEYIAGltetsaaTFVSYYWGGFMVGR----------FLGTALLKKISP 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 329 PTM-MFTAVSTVVMMLIMLNIPASTLAVCigLFFVGFCLNIGWPafTAYGMAVSDSKTY-PIASSIINSGgNLGGFVAPM 406
Cdd:cd17394 294 KKLlAVFALLGLLLLLGAIFTGGMVALYA--LVLVGFFNSIMFP--TIFSLALKGLGKHtKTGSGLLVMA-IVGGAVVPL 368
|
410 420 430
....*....|....*....|....*....|..
gi 378977814 407 AAGFLLDKTGSFNSVFtyfgICAAIGLVVILF 438
Cdd:cd17394 369 IQGAVADDAAGLRIAF----LVPLLCFAYILF 396
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-189 |
9.25e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.05 E-value: 9.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 17 YRFVVLTMIFLVYAINYadrTNIGAVLP-FIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGF 95
Cdd:cd17316 177 RRTLLLILLWFFISFGY---YGLTTFLPtYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 96 SAFTWLMG--TVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWG- 172
Cdd:cd17316 254 GILALPLFylLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGg 333
|
170 180
....*....|....*....|
gi 378977814 173 ---WRWVFFSFAIPGIVAAI 189
Cdd:cd17316 334 tgvPALILALLAIVALIVAL 353
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
25-189 |
1.07e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 25 IFLVYAINYADRTNIGAVLP-FIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKR-GTRGLVSLSIFGFSAFTWLM 102
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSlFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRlGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 103 GTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAI 182
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338
|
....*..
gi 378977814 183 PGIVAAI 189
Cdd:cd17330 339 LLLIALF 345
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
35-439 |
1.21e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 40.62 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 35 DRTNIGAVLPFIIDEFH-INNFeaGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKL 113
Cdd:cd17502 11 DQTIVATALPTIVAEFGgLSLV--SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 114 VRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIawyl 193
Cdd:cd17502 89 GRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALA---- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 194 lvkskpaesgfvsqselaeinagreshnnsvreniliaerftwldkIIRVkkmapidtakglFTSKNILGDCLAYFMMVS 273
Cdd:cd17502 165 ----------------------------------------------LLRT------------ILLSSIFGFLFGGALFGL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 274 VLYglltwIPLYLVKERGFDVmSMGFVASMPCIGGFIGAIGggwVSDKLLGR--RRKPTMMFTAVSTVVMMLIMLNIPAS 351
Cdd:cd17502 187 IYY-----LPLYFQLVLGDSA-TKSGVRLLPLIIGLVIGSI---ISGALISKtgRYKPLIVIGTILMSVGAGLLTTLTLD 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 352 TLAVCIG--LFFVGFCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVapmaagflldkTGSFNSVFTYFGICA 429
Cdd:cd17502 258 TSKWLLIgyLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTL-----------GVAITDVFLVALALA 326
|
410
....*....|
gi 378977814 430 AIGLVVILFL 439
Cdd:cd17502 327 ALAFLLSLFL 336
|
|
| PRK10133 |
PRK10133 |
L-fucose:H+ symporter permease; |
19-122 |
1.28e-03 |
|
L-fucose:H+ symporter permease;
Pssm-ID: 182260 [Multi-domain] Cd Length: 438 Bit Score: 41.03 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 19 FVVLTMIFLVYAInyADRTNiGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGF--- 95
Cdd:PRK10133 28 FALLCSLFFLWAV--ANNLN-DILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYalg 104
|
90 100 110
....*....|....*....|....*....|.
gi 378977814 96 SAFTW----LMGTVSSVFGLKLVRLGLGLSE 122
Cdd:PRK10133 105 AALFWpaaeIMNYTLFLVGLFIIAAGLGCLE 135
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
39-186 |
1.51e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.63 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGL 118
Cdd:cd17359 20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 119 GLSegpcpVGLASTINNWF-----PPKEKATATGVYIAATMF----APIIVPPLAVWIAVTW----GWRWVFFSFAIPGI 185
Cdd:cd17359 100 GLA-----VGGASALVPMYiaevaPAEIRGRLVSLNQLMIVFgqllAYIVNYLIANAGGADWlgaeGWRWMLGLEAIPAI 174
|
.
gi 378977814 186 V 186
Cdd:cd17359 175 L 175
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
39-197 |
1.79e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.21 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 39 IGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGL 118
Cdd:cd17372 18 LSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLV 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 378977814 119 GLSEGPCPVGLaSTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLVKS 197
Cdd:cd17372 98 GLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTPKT 175
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
43-196 |
2.74e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 39.90 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 43 LPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSE 122
Cdd:PRK11102 14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAA 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378977814 123 GPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVFFSFAIPGIVAAIAWYLLVK 196
Cdd:PRK11102 94 AAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
58-438 |
2.85e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.95 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 58 GAIASMFFLGYAVSQIPAGFFIAKRGTRGLVSLSIFGFSAFTWLMG--TVSSVFGLKLV-RLGLGLSEGPCPVGLASTIN 134
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGaaKGKWSVYQLIVgRVLVGIGVGGASVLAPMYIS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 135 NWFPPKEKATATGVY----IAATMFAPIIVPPLAVwIAVTWGWRWVFFSFAIPGIVAAIAWYLLVKSKpaeSGFVSQSEL 210
Cdd:pfam00083 129 EIAPKKLRGALGSLYqlaiTFGILLAYIFGLGLNK-TSNSDGWRIPLGLQLVPALLLIIGLLFLPESP---RWLVEKGRL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 211 AEINAGRESHNNSVRENILIAERFTWLDKIIRVKKMapidTAKGLFTSKNILGDCLAYFMMVSVL----YGLLTWIPLYL 286
Cdd:pfam00083 205 EEAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKA----SWKELFSTKTRRQRLLIGVMLQIFQqltgINAIFYYSTTI 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 287 VKERGFD--------VMSMGFVASMpciggfigaiGGGWVSDKlLGRRrkPTMMFTAVSTVVMMLIM-------LNIPAS 351
Cdd:pfam00083 281 FENLGLSdsflvtiiVGVVNFVFTF----------IAIFLVDR-FGRR--PLLLLGAAGMAICFVILgivallgVSKSDW 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 352 TLAVCI-GLFFVGFCLNIGW-PAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNsVFTYFGICA 429
Cdd:pfam00083 348 AGIVAIvFIALFIAFFAMGWgPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGY-TFFIFAGLL 426
|
....*....
gi 378977814 430 AIGLVVILF 438
Cdd:pfam00083 427 VLFIIFVFF 435
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
285-443 |
2.99e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.67 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 285 YLVKERGFDVMSMGFVASMPCIGGFIGAIGGGWVSDKLLGRRRKPTMMFTavSTVVMMLIMLnipASTLAVCIGL-FFVG 363
Cdd:TIGR00881 20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLIL--CAIVNLFFGF---STSLWVMAALwALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 364 FCLNIGWPAFTAYGMAVSDSKTYPIASSIINSGGNLGGFVAPMAAGFLLDKTGSFNSVFTYFGICAAI-GLVVILFL-DE 441
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIvSLICFLLLrDS 174
|
..
gi 378977814 442 PQ 443
Cdd:TIGR00881 175 PQ 176
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
139-439 |
3.38e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.50 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 139 PKEKATATGV----YIAATMFAPIIVPPLAVWIA--VTWGWRWVFFSFAIPGIVAAIAWYLLVKSKPAESGfvsqselae 212
Cdd:COG2211 142 YEERTRLSSWrfafAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE--------- 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 213 inagreshnnsvreniliaerftwldkiirvKKMAPIDTAKGLFTSKNILGDCLAYFMMVSVLYGLLTWIPLYLVKERGF 292
Cdd:COG2211 213 -------------------------------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGL 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 293 DVMSMGFVASMPCIGGFIGAIGGGWVSDKLlgRRRKPTMMFTAVSTVVMMLIMLNIPASTLAVCIGLFFVGFCLNIGWPA 372
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVL 339
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 378977814 373 FTAYGMAVSDSKTYP-------IASSIINSGGNLGGFVAPMAAGFLLDKTG----SFNSVFTYFGICAAIGLVVILFL 439
Cdd:COG2211 340 PWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLLLALFGyvagAAQSPSALTGIRLLFFLLPAVLL 417
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
37-191 |
3.82e-03 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 39.17 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 37 TNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRG--LVSLSIFGFSAFTWLMGTVSSVFGLKLV 114
Cdd:cd17409 16 TGVAPLLDTIRESFGLSTAQAGLLTTLPLLAFALFSPLAAKLARRYGLERslFAALLLIAAGIALRSTGSVWALYLGTAI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 115 rLGLGLSEGPcpVGLASTINNWFPPKeKATATGVY-----IAATMFAPIIVPPLAVWIavtWGWRWVFFSFAIPGIVAAI 189
Cdd:cd17409 96 -IGAGIAIGN--VLLPSLLKRDFPAR-VATLTGAYaltmgVGAALGSALVVPLAQVLA---FGWQLALGAFLVFPLVAAL 168
|
..
gi 378977814 190 AW 191
Cdd:cd17409 169 IW 170
|
|
| MFS_efflux_LmrB |
NF000060 |
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ... |
10-191 |
7.40e-03 |
|
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.
Pssm-ID: 411077 [Multi-domain] Cd Length: 479 Bit Score: 38.47 E-value: 7.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 10 TDARKTKYRFVVLTMIFLVYA--INYADRTNIGAVLPFIIDEFHINNFEAGAIASMFFLGYAVSQIPAGFFIAKRGTRGL 87
Cdd:NF000060 5 TTAKASQQYKVMPIMISLLLAgfIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 88 VSLSIFGFSAFTWLMGTVSSVFGLKLVRLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWI 167
Cdd:NF000060 85 FTVSLIFSILGTFIAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLV 164
|
170 180
....*....|....*....|....
gi 378977814 168 AVTWGWRWVFFsFAIPGIVAAIAW 191
Cdd:NF000060 165 LEHLNWHWIFW-ISLPFLVLALVF 187
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
45-202 |
7.61e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 7.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 45 FIIDEFHINNFEAGaiasMFFLGYAVSQIPAGFFIAKRGTRGL--------------VSLSIFGFSAFTWLMGTVSSVFg 110
Cdd:cd17471 22 FLTEELGASPLQIG----IFMTLSALSGIVVSQWLGRLSDRGGdrkplillallagaLGYLLFAFLRNYWVLLLVGVVL- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977814 111 lklvrLGLGLSEGPCPVGLASTINNWFPPKEKATATGVYIAATMFAPIIVPPLAVWIAVTWGWRWVF-FSFAIPGIVAAI 189
Cdd:cd17471 97 -----LSLGAAAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFlLAALLYLVVALL 171
|
170
....*....|...
gi 378977814 190 AWYLLVKSKPAES 202
Cdd:cd17471 172 VLFLLPSVKPPAQ 184
|
|
| |
