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Conserved domains on  [gi|378981155|ref|YP_005229296|]
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hypothetical protein KPHS_49960 [Klebsiella pneumoniae subsp. pneumoniae HS11286]

Protein Classification

DMT family transporter( domain architecture ID 581036)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0005215|GO:0005886
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EamA super family cl23754
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 1-122 6.27e-34

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


The actual alignment was detected with superfamily member PRK02971:

Pssm-ID: 474045  Cd Length: 129  Bit Score: 114.32  E-value: 6.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378981155   1 MGFFWALLSVGLVSAAQLLLRSAMVALPPLTDIVAFLQHLLHFQPGTFGLFFGLLGYLLSMVCWYFALHRLPLSKAYALL 80
Cdd:PRK02971   2 MGYLWGLASVLLASVAQLSLKWGMSRLPLLSHAWDFIAALLAFGLALRAVLLGLAGYALSMLCWLKALRYLPLSRAYPLL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 378981155  81 SLSYILVWAAAIWLPGWHEPFYWQSLLGVAIIVAGVLTIFWP 122
Cdd:PRK02971  82 SLSYALVYLAAMLLPWFNETFSLKKTLGVACIMLGVWLINLP 123
 
Name Accession Description Interval E-value
PRK02971 PRK02971
4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional
 1-122 6.27e-34

4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional


Pssm-ID: 235094  Cd Length: 129  Bit Score: 114.32  E-value: 6.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378981155   1 MGFFWALLSVGLVSAAQLLLRSAMVALPPLTDIVAFLQHLLHFQPGTFGLFFGLLGYLLSMVCWYFALHRLPLSKAYALL 80
Cdd:PRK02971   2 MGYLWGLASVLLASVAQLSLKWGMSRLPLLSHAWDFIAALLAFGLALRAVLLGLAGYALSMLCWLKALRYLPLSRAYPLL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 378981155  81 SLSYILVWAAAIWLPGWHEPFYWQSLLGVAIIVAGVLTIFWP 122
Cdd:PRK02971  82 SLSYALVYLAAMLLPWFNETFSLKKTLGVACIMLGVWLINLP 123
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
60-119 2.10e-03

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 35.07  E-value: 2.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378981155  60 SMVCWYFALHRLPLSKAYALLS-LSYILVWAAAIWLpgWHEPFYWQSLLGVAIIVAGVLTI 119
Cdd:COG2076   41 SFYLLSLALKTLPVGTAYAVWTgIGAVGTALVGILL--FGEPLSLARLLGIALIIAGVVGL 99
 
Name Accession Description Interval E-value
PRK02971 PRK02971
4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional
 1-122 6.27e-34

4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional


Pssm-ID: 235094  Cd Length: 129  Bit Score: 114.32  E-value: 6.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378981155   1 MGFFWALLSVGLVSAAQLLLRSAMVALPPLTDIVAFLQHLLHFQPGTFGLFFGLLGYLLSMVCWYFALHRLPLSKAYALL 80
Cdd:PRK02971   2 MGYLWGLASVLLASVAQLSLKWGMSRLPLLSHAWDFIAALLAFGLALRAVLLGLAGYALSMLCWLKALRYLPLSRAYPLL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 378981155  81 SLSYILVWAAAIWLPGWHEPFYWQSLLGVAIIVAGVLTIFWP 122
Cdd:PRK02971  82 SLSYALVYLAAMLLPWFNETFSLKKTLGVACIMLGVWLINLP 123
PRK15051 PRK15051
4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional
 60-117 6.06e-04

4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional


Pssm-ID: 185011  Cd Length: 111  Bit Score: 36.71  E-value: 6.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 378981155  60 SMVCWYFALHRLPLSKAYALLSLSYILVWAAAIWLpgWHEPFYWQSLLGVAIIVAGVL 117
Cdd:PRK15051  50 AMVLWLLVLQNVPVGIAYPMLSLNFVWVTLAAVKL--WHEPVSPRHWCGVAFIIGGIV 105
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
60-119 2.10e-03

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 35.07  E-value: 2.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378981155  60 SMVCWYFALHRLPLSKAYALLS-LSYILVWAAAIWLpgWHEPFYWQSLLGVAIIVAGVLTI 119
Cdd:COG2076   41 SFYLLSLALKTLPVGTAYAVWTgIGAVGTALVGILL--FGEPLSLARLLGIALIIAGVVGL 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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