NCBI Conserved Domain Search

Conserved domains on [gi|49176132|ref|YP_025306|]

View

purine nucleoside transporter PunC [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

MFS transporter( domain architecture ID 11485165)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

Zoom to residue level

show extra options »

Show site features Horizontal zoom: ×

List of domain hits

Name

Accession

Description

Interval

E-value

PRK11043

Bcr/CflA family multidrug efflux MFS transporter;

1-403

0e+00

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 657.35 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    1 MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTI 80
Cdd:PRK11043   1 MQPSKGFLVYLAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   81 FALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQ 160
Cdd:PRK11043  81 FALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  161 AIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI 240
Cdd:PRK11043 161 AIFATLFAITLLLILPTLRLKPSKKARKQSQDALTFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFILEQMGYSPADI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  241 GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQ 320
Cdd:PRK11043 241 GLSYVPQTIAFLVGGYGCRAALQKWGGEQLLPWLLVLFAVSVIAIWLASLLSHPSLVPLLIPFCVMAAANGAIYPIVVAQ 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  321 ALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLisISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHS 400
Cdd:PRK11043 321 ALRPFPQATGKAAALQNTLQLGLCFLASLLVSAL--ISTPLLTTGSVMLSTVVLVALGYMLQRKAEWGDFNHPFTEVAHS 398


                 ...
gi 49176132  401 ESH 403
Cdd:PRK11043 399 ESH 401

Name

Accession

Description

Interval

E-value

PRK11043

Bcr/CflA family multidrug efflux MFS transporter;

1-403

0e+00

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 657.35 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    1 MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTI 80
Cdd:PRK11043   1 MQPSKGFLVYLAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   81 FALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQ 160
Cdd:PRK11043  81 FALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  161 AIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI 240
Cdd:PRK11043 161 AIFATLFAITLLLILPTLRLKPSKKARKQSQDALTFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFILEQMGYSPADI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  241 GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQ 320
Cdd:PRK11043 241 GLSYVPQTIAFLVGGYGCRAALQKWGGEQLLPWLLVLFAVSVIAIWLASLLSHPSLVPLLIPFCVMAAANGAIYPIVVAQ 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  321 ALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLisISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHS 400
Cdd:PRK11043 321 ALRPFPQATGKAAALQNTLQLGLCFLASLLVSAL--ISTPLLTTGSVMLSTVVLVALGYMLQRKAEWGDFNHPFTEVAHS 398


                 ...
gi 49176132  401 ESH 403
Cdd:PRK11043 399 ESH 401

efflux_Bcr_CflA

TIGR00710

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...

2-382

1.24e-150

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.

Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 431.42 E-value: 1.24e-150

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132     2 QPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIF 81
Cdd:TIGR00710   1 KSAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    82 ALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQA 161
Cdd:TIGR00710  81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   162 IFATLFAITVVLILPIFWLKPTTKARNN----SQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSE-MGYS 236
Cdd:TIGR00710 161 IFAFLSLAGILLSALIFFILPETLPYEAriqiSTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDiMGVS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   237 PAVIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPI 316
Cdd:TIGR00710 241 PSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSI 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49176132   317 VVAQALRPFPHATGRAAALQNTLQLGLCFLASLVVSwLISISTPLLTTTSVMLSTVVLVALGYMMQ 382
Cdd:TIGR00710 321 AMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVS-LIHGNTAWPMSLSCLVLAVVSVLAFYYLS 385

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

8-380

4.33e-99

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 299.88 E-value: 4.33e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   8 LVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLG 87
Cdd:cd17320   1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  88 MLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLF 167
Cdd:cd17320  81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 168 AITVVLILPIFWLKPTTKARNNSQDGL-----TFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSE-MGYSPAVIG 241
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLssllrAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEqLGLSPAQFG 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 242 LSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQA 321
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 49176132 322 LRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYM 380
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

5-340

3.64e-43

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 153.98 E-value: 3.64e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   5 KRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALG 84
Cdd:COG2814   9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  85 SLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFA 164
Cdd:COG2814  89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 165 TLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSE-MGYSPAVIGLS 243
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 244 YVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGfishvSLVEILIPFCVMAIANGAIYPIVVAQALR 323
Cdd:COG2814 249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-----SLWLLLLALFLLGFGFGLLFPLLQALVAE 323

                       330
                ....*....|....*...
gi 49176132 324 PFP-HATGRAAALQNTLQ 340
Cdd:COG2814 324 LAPpEARGRASGLYNSAF 341

MFS_1

pfam07690

Major Facilitator Superfamily;

11-340

1.75e-27

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.36 E-value: 1.75e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    11 LAGLSVLGFLATDMYLPAFA-AIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGML 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    90 WVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAI 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   170 TVVLILPI-FWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAAC-----SASFFAWLTGSPFILSEMGYSPAVIGLS 243
Cdd:pfam07690 161 SLLAAVLLlLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLalllfGFAFFGLLTYLPLYQEVLGLSALLAGLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   244 YVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFIshVSLVEILIPFCVMAIANGAIYPIVVAQALR 323
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT--LSSLWLLLALLLLGFGFGLVFPALNALVSD 318

                         330
                  ....*....|....*...
gi 49176132   324 PFP-HATGRAAALQNTLQ 340
Cdd:pfam07690 319 LAPkEERGTASGLYNTAG 336

Name

Accession

Description

Interval

E-value

PRK11043

Bcr/CflA family multidrug efflux MFS transporter;

1-403

0e+00

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 657.35 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    1 MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTI 80
Cdd:PRK11043   1 MQPSKGFLVYLAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   81 FALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQ 160
Cdd:PRK11043  81 FALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  161 AIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI 240
Cdd:PRK11043 161 AIFATLFAITLLLILPTLRLKPSKKARKQSQDALTFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFILEQMGYSPADI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  241 GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQ 320
Cdd:PRK11043 241 GLSYVPQTIAFLVGGYGCRAALQKWGGEQLLPWLLVLFAVSVIAIWLASLLSHPSLVPLLIPFCVMAAANGAIYPIVVAQ 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  321 ALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLisISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHS 400
Cdd:PRK11043 321 ALRPFPQATGKAAALQNTLQLGLCFLASLLVSAL--ISTPLLTTGSVMLSTVVLVALGYMLQRKAEWGDFNHPFTEVAHS 398


                 ...
gi 49176132  401 ESH 403
Cdd:PRK11043 399 ESH 401

efflux_Bcr_CflA

TIGR00710

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...

2-382

1.24e-150

Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 431.42 E-value: 1.24e-150

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132     2 QPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIF 81
Cdd:TIGR00710   1 KSAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    82 ALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQA 161
Cdd:TIGR00710  81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   162 IFATLFAITVVLILPIFWLKPTTKARNN----SQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSE-MGYS 236
Cdd:TIGR00710 161 IFAFLSLAGILLSALIFFILPETLPYEAriqiSTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDiMGVS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   237 PAVIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPI 316
Cdd:TIGR00710 241 PSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSI 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49176132   317 VVAQALRPFPHATGRAAALQNTLQLGLCFLASLVVSwLISISTPLLTTTSVMLSTVVLVALGYMMQ 382
Cdd:TIGR00710 321 AMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVS-LIHGNTAWPMSLSCLVLAVVSVLAFYYLS 385

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

8-380

4.33e-99

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 299.88 E-value: 4.33e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   8 LVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLG 87
Cdd:cd17320   1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  88 MLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLF 167
Cdd:cd17320  81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 168 AITVVLILPIFWLKPTTKARNNSQDGL-----TFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSE-MGYSPAVIG 241
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLssllrAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEqLGLSPAQFG 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 242 LSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQA 321
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 49176132 322 LRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYM 380
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

5-340

3.64e-43

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 153.98 E-value: 3.64e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   5 KRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALG 84
Cdd:COG2814   9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  85 SLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFA 164
Cdd:COG2814  89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 165 TLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSE-MGYSPAVIGLS 243
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 244 YVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGfishvSLVEILIPFCVMAIANGAIYPIVVAQALR 323
Cdd:COG2814 249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-----SLWLLLLALFLLGFGFGLLFPLLQALVAE 323

                       330
                ....*....|....*...
gi 49176132 324 PFP-HATGRAAALQNTLQ 340
Cdd:COG2814 324 LAPpEARGRASGLYNSAF 341

PRK11102

Bcr/CflA family multidrug efflux MFS transporter;

20-352

2.38e-42

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 152.38 E-value: 2.38e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   20 LATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLV 99
Cdd:PRK11102   5 LAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  100 LRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIFW 179
Cdd:PRK11102  85 MRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFF 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  180 LKPTTKARNNSQD---GLT---FTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEM-GYSPAVIG----LSYVPQT 248
Cdd:PRK11102 165 FIPETLPKERRQPfhlRTTirnFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELnGVSPQNFGyyfaLNIVFLF 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  249 IAFLIGG-----YGCRAALQKWQGKQLLP--WLLvlfavsVIATWAAGFISHVSLVEILIPfCVMAIANGAIypivvAQA 321
Cdd:PRK11102 245 VMTIINSrfvrrVGALNMLRFGLWIQFIMgiWLV------VSALLDLGFWALVVGVAAFVG-CVSMISSNAM-----AVI 312

                        330       340       350
                 ....*....|....*....|....*....|.
gi 49176132  322 LRPFPHATGRAAALQNTLQLGLCFLASLVVS 352
Cdd:PRK11102 313 LDEFPHMAGTASSLAGTLRFGIGAIVGALLS 343

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

16-376

8.78e-31

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 121.13 E-value: 8.78e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  16 VLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAA 95
Cdd:cd17321   6 FLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  96 TLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLil 175
Cdd:cd17321  86 FLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA-- 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 176 pifwlkpttkarnnsqdgltftdLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEM-GYSPAVIGLSYVPQTIAFLIG 254
Cdd:cd17321 164 -----------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVlGYSPLQAGLALLPLALAMLVA 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 255 GYGCRAALQKWQGKQLLPWLLVLFAVSVIatWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQALRPFPHA-TGRAA 333
Cdd:cd17321 221 APLAGRLADRFGPRLVLVAGLLLTAVGLL--LLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEkAGAAS 298

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 49176132 334 ALQNTL-QLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVA 376
Cdd:cd17321 299 GILNTArQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAA 342

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

11-377

9.31e-31

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 121.14 E-value: 9.31e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  11 LAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLW 90
Cdd:cd17474   4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  91 VENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSwLLVHFSWQAIFATLFAIT 170
Cdd:cd17474  84 SDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFFLLAALI 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 171 VVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSAS---FFAWLTGSPFILS-EMGYSPAVIGLSYVP 246
Cdd:cd17474 163 PVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYfflYFAFLTYLPFLLElLYGISPIIIGLLFAG 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 247 QTIAFLIGGYGCRAALQK-WQGKQLLPWLLVLFAVSVIATWAAgfishVSLVEILIPFCVMAIANGAIYPIVVAQALRPF 325
Cdd:cd17474 243 WSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFV-----PSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 49176132 326 P-HATGRAAALQNTLQLGLCFLASLVVSWL---ISISTPLLTTTSVMLSTVVLVAL 377
Cdd:cd17474 318 PeEERGTASSLYNFVRFLGQAVGPLLFGLLleiFGLSAPFLVGAAIALAAAVLLAL 373

MFS_1

pfam07690

Major Facilitator Superfamily;

11-340

1.75e-27

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.36 E-value: 1.75e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    11 LAGLSVLGFLATDMYLPAFA-AIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGML 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    90 WVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAI 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   170 TVVLILPI-FWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAAC-----SASFFAWLTGSPFILSEMGYSPAVIGLS 243
Cdd:pfam07690 161 SLLAAVLLlLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLalllfGFAFFGLLTYLPLYQEVLGLSALLAGLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   244 YVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFIshVSLVEILIPFCVMAIANGAIYPIVVAQALR 323
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT--LSSLWLLLALLLLGFGFGLVFPALNALVSD 318

                         330
                  ....*....|....*...
gi 49176132   324 PFP-HATGRAAALQNTLQ 340
Cdd:pfam07690 319 LAPkEERGTASGLYNTAG 336

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

14-254

3.38e-27

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 111.13 E-value: 3.38e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  14 LSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVEN 93
Cdd:cd17323   7 LTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  94 AATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFA--AIMPLVGlsPALAPLLGSWLLVHFSWQAIFATLFAIT- 170
Cdd:cd17323  87 IAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGvySLGPLLG--PALGPIIGGFITQSLGWRWIFWFLAIISg 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 171 VVLILPIFWLKPttkarnnsqdgltftdLLRSKTYrgNVLIYaacsASFFAWLTGSPFILSEM-GYSPAVIGLSYVPQTI 249
Cdd:cd17323 165 FCLILIFLFLPI----------------VLLLGLY--VGLVY----AILYLFLTAFPYVFGEVyGFSPGEVGLMYLPIGI 222


                ....*
gi 49176132 250 AFLIG 254
Cdd:cd17323 223 GALIG 227

emrD

PRK11652

multidrug transporter EmrD;

7-378

5.44e-27

multidrug transporter EmrD;

Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 110.77 E-value: 5.44e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    7 FLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSL 86
Cdd:PRK11652   9 LLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   87 GMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATL 166
Cdd:PRK11652  89 VALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  167 FAI-TVVLILPIFWLKPT-TKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSE-MGYSPAVIGLS 243
Cdd:PRK11652 169 LLLgAGVTFSMARWMPETrPADARRTRVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAvLGLSSMTVSIL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  244 YVPQTIAFLIGGYgcRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQALR 323
Cdd:PRK11652 249 FILPIPAAFFGAW--FAGRPNKRFSTLMWQSVICCLLAGLLMWIPGWFGVMNVWTLLVPAALFFFGAGMLFPLATSGAME 326

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 49176132  324 PFPHATGRAAALQNTLQlglcFLASLVVSWLISI--STPLLTTTSVMLSTVVLVALG 378
Cdd:PRK11652 327 PFPYLAGTAGALLGGLQ----NIGSGLAALLSAMlpQTGQFSLGLLMTLMGLLILLC 379

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

6-358

1.55e-26

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 109.19 E-value: 1.55e-26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   6 RFLVWLAGLSVLGFLATDMYLPAFAA--IQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFAL 83
Cdd:COG2271   8 RWRILALLFLAYFLNYLDRSNLSVAAppLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  84 GSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIF 163
Cdd:COG2271  88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 164 ATLFAITVVLILPIFWLkpttkarnnsqdgltftdllrsktyrgNVLIYAACSASFFAWLT-GSPFILSEMGYSPAVIGL 242
Cdd:COG2271 168 LILGLPGLLLALLRFWL---------------------------LALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQAGL 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 243 SYVPQTIAFLIGGYGCrAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILipFCVMAIANGAIYPIVVAQAL 322
Cdd:COG2271 221 LLSLPFLAGIVGSLLG-GWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIAL--LFLAGFGLGGAFGLLWALAA 297

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 49176132 323 RPFP-HATGRAAALQNTLQLGLCFLASLVVSWLISIS 358
Cdd:COG2271 298 ELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334

PRK10473

MdtL family multidrug efflux MFS transporter;

5-335

1.94e-25

MdtL family multidrug efflux MFS transporter;

Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 106.64 E-value: 1.94e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    5 KRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALG 84
Cdd:PRK10473   2 SRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   85 SLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFA 164
Cdd:PRK10473  82 SLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  165 TLFAI-TVVLILPIFWLKPTTKARNNSQDGLTF--TDLLRSKTYRGNVLIYAACSASFFAWLTGSPFIL-SEMG-----Y 235
Cdd:PRK10473 162 TMAAMgILVLLLSLFILKETRPARAPAASSKPRenSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLmEQMGfsrgeY 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  236 SPAVIGLSYVPQTIAFLIggygcRAALQKWQGKQLLPWLLVLFAVSVIAtwaagFISHVSLVEILIPFCVMAIANGAIYP 315
Cdd:PRK10473 242 AIIMALTAGVSMTVSFST-----PFALGIFKPRTLMLTSQVLFLAAGIT-----LALSPSHAVSLFGITLICAGFSVGFG 311

                        330       340
                 ....*....|....*....|
gi 49176132  316 IVVAQALRPFPHATGRAAAL 335
Cdd:PRK10473 312 VAMSQALGPFSLRAGVASST 331

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

14-379

9.35e-25

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 104.20 E-value: 9.35e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  14 LSVLGFLATDMYLPAFAAiqaDLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVEN 93
Cdd:cd17325   7 LDMLGYGIIIPILPLYAE---SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  94 AATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVL 173
Cdd:cd17325  84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 174 ILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFA-------WLTGSPFILSEMGYSPAVIGLSYVP 246
Cdd:cd17325 164 LVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLafafgalEPFLPLYAAELGGLSPAQIGLLFGA 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 247 QTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGfishvSLVEILIPFCVMAIANGAIYPIVVAQ-ALRPF 325
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFPATLALlADIVP 318

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 49176132 326 PHATGRAAALQNTLQ-LGLcFLASLVVSWL---ISISTPLLTTTSVMLSTVVLVALGY 379
Cdd:cd17325 319 PEGRGTAMGLFNTAFsLGM-VLGPLLGGFLydaFGFATPFLAAAALLLLAAVLFLLLR 375

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

5-262

7.79e-24

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 100.27 E-value: 7.79e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   5 KRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALG 84
Cdd:COG0477  13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  85 SLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFA 164
Cdd:COG0477  93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 165 TLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVIGLSY 244
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252

                       250
                ....*....|....*...
gi 49176132 245 VPQTIAFLIGGYGCRAAL 262
Cdd:COG0477 253 LLALLLLAALLLLLLLLL 270

PRK15403

multidrug efflux MFS transporter MdtM;

19-246

1.34e-23

multidrug efflux MFS transporter MdtM;

Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 101.44 E-value: 1.34e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   19 FLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLL 98
Cdd:PRK15403  29 YLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   99 VLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIF 178
Cdd:PRK15403 109 IARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLL 188

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49176132  179 WLKPTTKARNNSqdGLTFTDLLRS--KTYRGNVLIYAACSASF-----FAWLTGSPFILSEM-GYSPAVIGLSYVP 246
Cdd:PRK15403 189 LAMPETVKRGAV--PFSAKSVLRDfrNVFRNRLFLTGAATLSLsyipmMSWVAVSPVILIDAgGMTTSQFAWTQVP 262

PRK15402

MdfA family multidrug efflux MFS transporter;

19-254

3.73e-23

MdfA family multidrug efflux MFS transporter;

Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 100.01 E-value: 3.73e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   19 FLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLL 98
Cdd:PRK15402  26 YIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   99 VLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIF 178
Cdd:PRK15402 106 LLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLW 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  179 WLKPTTKARNNSQDGLT-----FTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFIL-SEMGYSPAVIGLSYVPQTIAFL 252
Cdd:PRK15402 186 RAMPETAGRVGEKLSLKelgrdYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVILiSGEQLSSYEYGLLQVPVFGALI 265


                 ..
gi 49176132  253 IG 254
Cdd:PRK15402 266 AG 267

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

9-338

1.76e-21

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 94.92 E-value: 1.76e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   9 VWLAGLSVLGFLATDMYL-PAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLG 87
Cdd:cd17324   1 LLALALAAFAIGTTEYVIqGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  88 MLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLF 167
Cdd:cd17324  81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 168 AITVVLILPIFWLKPTTKARNNSQDGL--TFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPaviglsyv 245
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGLlsSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFS-------- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 246 PQTIAFLIGGYGCRAALQKWQGKQLLPW-----LLVLFAVSVIATWAAGFISHVSLVeILIPFCVMAIANGAIYPIVVAQ 320
Cdd:cd17324 233 SSAIIGLLLLFGVAGVVGSPLAGRLADRggrraLLIALLLLAAALLLLTLLGPSPLL-LLVGLVLWGLGFFAAHSALQTR 311

                       330
                ....*....|....*...
gi 49176132 321 ALRPFPHATGRAAALQNT 338
Cdd:cd17324 312 VLRLAPEARGLASSLYLA 329

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

11-379

3.63e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.03 E-value: 3.63e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  11 LAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLW 90
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  91 VENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVH--FSWQAIFATLFA 168
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 169 ITVVLILPIFWLKPTTKARNNSQD--------GLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSP-FILSEMGYSPAV 239
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNeeassksvLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPlFLLDLGGLSVAV 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 240 IGLSYVPQTIAFLIGGYGCRAALQKWQGkqlLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVA 319
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIG---RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 320 QALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGY 379
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

28-352

4.54e-21

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 93.79 E-value: 4.54e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  28 AFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVG 107
Cdd:cd17503  18 ALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 108 VCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIF--ATLFAITVVLILPIFWLKpttk 185
Cdd:cd17503  98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFyiNLPIGILALLLAPLLDLR---- 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 186 arnnsqdgltftdLLRSKTYRGNVLIYAACSASFFawltGSPFILSEM-----GYSPAVIGLSYVPQTIAFLIGGYGCRA 260
Cdd:cd17503 174 -------------LFKDRNFTLGLLLSFLLGLGLF----GAMFLLPLYlqnvlGYSAFESGLVLAPGGLASAILSPLVGR 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 261 ALQKWQGKQLLPWLLVLFAVSVIatWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQALRPFPHA-TGRAAALQNTL 339
Cdd:cd17503 237 LLDKFGPRLLLLAGLLLLALGTL--LLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEqIGDATALFNTI 314

                       330
                ....*....|....
gi 49176132 340 -QLGLCFLASLVVS 352
Cdd:cd17503 315 rQLGGSIGTALLAT 328

2_A_01_02

TIGR00880

Multidrug resistance protein;

48-183

1.07e-20

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 87.32 E-value: 1.07e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    48 SLFLAGFAAAQLLWGPLS----DRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYY 123
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49176132   124 PSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAI-TVVLILPIFWLKPT 183
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILaLAAFILLAFLLPET 141

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

3-380

6.37e-20

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.71 E-value: 6.37e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   3 PGKRFLVWLAGLSV-LGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIF 81
Cdd:COG2223   1 SGRWRVLLLATLAFfLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  82 ALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQA 161
Cdd:COG2223  81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 162 IFATLFAITVVLILPIFWL---KPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEM-GYSP 237
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFlrdPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSA 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 238 AVIGLSYVPQTIAFLIGGYGCRAALQKWQGKqllPWLLVLFAVSVIATWAAGFISHvSLVEILIPFCVMAIANGAIYPIV 317
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDRIGGR---RVLLIVFALMALGLLLLALALG-SLWLFLVLFLLLGLALGGGNGAV 316

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 49176132 318 VAQALRPFP-HATGRAAALQNTLQLGLCFLASLVVSWLISIsTPLLTTTSVMLSTVVLVALGYM 380
Cdd:COG2223 317 FALVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA-TGSYTAAFLVFAVLALVALVLT 379

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

15-335

1.89e-18

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 86.11 E-value: 1.89e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  15 SVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENA 94
Cdd:cd17489   5 NFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  95 ATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLI 174
Cdd:cd17489  85 ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLAL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 175 LPIFWLK-PTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSpaVIGLSYVPQTIAFLI 253
Cdd:cd17489 165 LLVFLVKdPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLL 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 254 GGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGfishvSLVEILIPFCVMAIANGAIYPIVVAQALRPFPHAtGRAA 333
Cdd:cd17489 243 SRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAG-----SPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH-RRGA 316


                ..
gi 49176132 334 AL 335
Cdd:cd17489 317 AN 318

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

27-378

6.24e-18

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 84.55 E-value: 6.24e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  27 PAFAAIQADLqTPASAVSASL-----SLFLAGFAaaqLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLR 101
Cdd:cd17473  20 PALPAIAQHF-VPNSELLVPLlltlpALFIALFA---PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 102 FVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWlLVHFSWQAIFAT-LFAItvvLILPIFWL 180
Cdd:cd17473  96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGA-LAEIGWRAPFLVyLLAL---PVLILVLL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 181 KPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAA---CSASFFAWLTGSPFILSEMG-YSPAVIGLSYVPQTIAFLIGGY 256
Cdd:cd17473 172 FLPEPARKSKSAASPGAATAAALPWKRVLPIYFLaflAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGAL 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 257 GCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGfishvSLVEILIPFCVMAIANGAIYPIVVAQALRPFP-HATGRAAAL 335
Cdd:cd17473 252 LFGRLKRRLGKRRLLAIGFALMALGFLLLALAS-----GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPpELRGRAMGI 326

                       330       340       350       360
                ....*....|....*....|....*....|....*....|...
gi 49176132 336 QNTLQLGLCFLASLVVSWLISISTPLltTTSVMLSTVVLVALG 378
Cdd:cd17473 327 VTSAFFLGQFLSPLVLGPLVNLTGGL--SGAFLILGVLALVLA 367

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

27-383

1.00e-17

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.15 E-value: 1.00e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  27 PAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAV 106
Cdd:COG2807  39 PLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 107 GVCAAAVIWQALVTDYYPsQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILP-IFWLKPTTK 185
Cdd:COG2807 119 GIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLwLPLLRRRPA 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 186 ARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVIGLSYVPQTIAFLIGGYGCRAALQKW 265
Cdd:COG2807 198 AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL 277

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 266 QGKQllPWLLVLFAVSVIATWAAGFISHVSLveiLIPFCVMAIANGAIYPIVVAQALR--PFPHATGRAAALQNTLQLGL 343
Cdd:COG2807 278 GDRR--PLLLLLGLLGLAGLLGLLLAPGSLP---WLWAVLLGLGQGGLFPLALTLIGLraRTPAEAAALSGMAQSVGYLL 352

                       330       340       350       360
                ....*....|....*....|....*....|....*....|...
gi 49176132 344 CFLASLVVSWLISIS---TPLLTTTSVMLstVVLVALGYMMQR 383
Cdd:COG2807 353 AALGPLLVGALHDATgswTAALLLLAALA--VLMLVAGLLAGR 393

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

28-358

1.41e-17

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 83.39 E-value: 1.41e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  28 AFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVG 107
Cdd:cd17319  25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 108 VCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLIlpIFWlkpttkar 187
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLA--VLW-------- 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 188 nnsqdgltftdLLRSKTYRGNVLIYAACSASFFAWLTGSPFIL-SEMGYSPAVIGL-SYVPQTIAFLIGGYGCRAALQKW 265
Cdd:cd17319 175 -----------WFYLRQVWGLALGYFGINYALYGLLTWLPTYLkQARGFSLKQVGLlAAIPFLAGAIGMILGGRLSDRLL 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 266 QGKQLLPwLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQALRPfPHATGRAAALQNTLQLGLCF 345
Cdd:cd17319 244 RGARRLV-IIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLP-GEAAATAGGLINSGGNLGGF 321

                       330
                ....*....|...
gi 49176132 346 LASLVVSWLISIS 358
Cdd:cd17319 322 VAPLLIGYLVDAT 334

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

11-324

4.50e-17

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 81.86 E-value: 4.50e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  11 LAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLW 90
Cdd:cd17504   1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  91 VENAATLLVLRFVQAVGVcAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAIT 170
Cdd:cd17504  81 APNLPVLIAGRALQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 171 VVLILpifwLKPttkarnnsqdgLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSE-----MGYSPAVIGLSYV 245
Cdd:cd17504 160 VLLAA----LVP-----------LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLL 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 246 PQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSviatWAAGFISHVSLVEILIPFCVMAIANGAIY---PIVVAQAL 322
Cdd:cd17504 225 PGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVG----LLLLALLHSSLWALVVALLLIGIGLGLAFaslPNIVVESV 300


                ..
gi 49176132 323 RP 324
Cdd:cd17504 301 PP 302

MFS_YajR_like

cd17472

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...

11-373

1.26e-16

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 80.72 E-value: 1.26e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  11 LAGLSVLGFLATDMYLPAFAAIQADLQTpASAVSASLSLFLAGFAAA--QLLWGPLSDRYGRKPVLLIGLTIFALGSLGM 88
Cdd:cd17472   1 LSLIFSLRMLGMFLVLPVLSVYAKSLPG-ATPTLIGLALGIYGLTQAifQIPFGLLSDRIGRKPVILFGLLLFIAGSLLA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  89 LWVENAATLLVLRFVQAVGVCAAAVIwqALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFA 168
Cdd:cd17472  80 AYATSIYGLILGRALQGSGAISSVVM--ALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 169 ITVVLILPIFWLKPTTKARNNSQD--GLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVIGLSYVP 246
Cdd:cd17472 158 LSLVSLLILLFFVPDPPKIVQISEkeKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLP 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 247 QT-IAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGfISHVSLVEILIPFCVMAIANGAIYPIVVAQALRpf 325
Cdd:cd17472 238 AIlIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAA-TSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAP-- 314

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 49176132 326 PHATGRAAALQNTLQLGLCFLASLVVSWL---ISISTPLLTTTSVMLSTVV 373
Cdd:cd17472 315 KEYRGTAMGIYNTSQFLGSFLGGALGGLLwglLGYSSVFLTILILALLWLL 365

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

2-383

6.75e-16

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 78.74 E-value: 6.75e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   2 QPGKRFLVWLAGLSVLGF-LATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTI 80
Cdd:COG0738   3 KKNYRRALIAIYLLFFLWgFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  81 FALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRI--FAAIMPLVGLspaLAPLLGSWLL---V 155
Cdd:COG0738  83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLnlLHAFFSLGAL---LGPLLGGLLIllgL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 156 HFSWQAIFATLFAITVVLILPIFWLK---PTTKARNNSQDGLTFTDLLRSKTYRGNVLI---YAACSASFFAWLtgSPFI 229
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRSKlpeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAiflYVGAEGAIGDWL--PLYL 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 230 LSEMGYSPAVIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLlpwLLVLFAVSVIATWAAGFISHVSLveILIPFCVMAIA 309
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL---LRLSALLAAVGLLLALLAPGPWL--ALIGLALVGLG 312

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 49176132 310 NGAIYPIVVAQALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQR 383
Cdd:COG0738 313 LSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

19-377

1.63e-15

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 77.26 E-value: 1.63e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  19 FLATDMYLPAFAAIQA----DLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENA 94
Cdd:cd17316  10 FDAYDFFLIGFVAPVLaaefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  95 ATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLI 174
Cdd:cd17316  90 ILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPA 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 175 LPIFWLKPTTKarnnsqdgltftdllrsktyrGNVLIYAACSASFFAWLTGSP-FILSEMGYSPAVIGLSYVPQTIAFLI 253
Cdd:cd17316 170 LLALLLRRRTL---------------------LLILLWFFISFGYYGLTTFLPtYLQTVLGLSPATSSLYLLLISLGALV 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 254 GGYGCRAALQKWQGKqllPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQALRPFP-HATGRA 332
Cdd:cd17316 229 GALIAGLLSDRIGRK---KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPtEVRATG 305

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 49176132 333 AALQNTLQLGLCFLASLVVSWLIsISTPLLTTTSVMLSTVVLVAL 377
Cdd:cd17316 306 VGLSYNLGRLGGGGAPPLIALLL-ASTGGTGVPALILALLAIVAL 349

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

28-179

2.28e-14

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 73.77 E-value: 2.28e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  28 AFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVG 107
Cdd:cd17365  21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49176132 108 VCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFAtLFAITVVLILPIFW 179
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL-LGGVPPLILLPLLR 171

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

2-180

7.34e-14

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.39 E-value: 7.34e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132     2 QPGKRFLVWLAGLSVLGFL--ATDMYLPAFAA--IQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIG 77
Cdd:TIGR00895   9 QPLSRYQWRAIILSFLIMLmdGYDLAAMGFAApaISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    78 LTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHF 157
Cdd:TIGR00895  89 ILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF 168

                         170       180
                  ....*....|....*....|....
gi 49176132   158 SWQAIFATLFAITVVLILP-IFWL 180
Cdd:TIGR00895 169 GWRSLFYVGGIAPLLLLLLlMRFL 192

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

50-357

2.38e-13

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 70.67 E-value: 2.38e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  50 FLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVN 129
Cdd:cd17502  39 YLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERG 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 130 RIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIF---ATLFAITVVLIlPIFWLkpttkarnnsqdgltftdllrsktyr 206
Cdd:cd17502 119 KYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFyinLPIGGLALALL-RTILL-------------------------- 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 207 gnVLIYAAC-SASFFAWLTGSP-FILSEMGYSPAVIGLSYVPQTIAFLIGGYGCRAALQKWqgKQLLPWLLVLFAVSVIA 284
Cdd:cd17502 172 --SSIFGFLfGGALFGLIYYLPlYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKT--GRYKPLIVIGTILMSVG 247

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49176132 285 TWAAGFISHVSLVEILIPFCVMA-IANGAIYP--IVVAQALRPfPHATGRAAALQNTLQ-LGLCFLASLVVSWLISI 357
Cdd:cd17502 248 AGLLTTLTLDTSKWLLIGYLILLgLGLGIGFQqpLVAVQNAVP-PADVGVATATNTFFRsLGGTLGVAITDVFLVAL 323

MFS_YcxA_like

cd17355

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...

29-326

1.63e-12

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.45 E-value: 1.63e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  29 FAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGV 108
Cdd:cd17355  26 IIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 109 CAA-AVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQA---IFATLFAITVVLILPIFWLKPTT 184
Cdd:cd17355 106 AGTlAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTallVLALLALLVLVPVLLLLRRRPAD 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 185 KARNNSQD------GLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVIGLSYVPQTIAFLIGGYGC 258
Cdd:cd17355 186 LALRAYDDaspaspGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLS 265

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49176132 259 RAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILipfcVMAIANGAIYPIVVAQALRPFP 326
Cdd:cd17355 266 GWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAA----LFGLGWGATVPLTAALAARYFG 329

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

8-289

9.99e-12

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 65.71 E-value: 9.99e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   8 LVWLAGLSVLGFLATDMYLPaFAAIQADLQTPASAVSASLSLFLAGFAA--AQLLWGPLSDRYGRKPVLLIGLTIFALGS 85
Cdd:cd17329   1 LWVLLIGSFLNRLGFFMVWP-FMAIYLHQQLGLSASIVGLVLALSAVAGivASLIGGRLADRFGRKPVMLAGLLLRALGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  86 LGMLWVENAATLLVLRFvqAVGVCAAAVIW--QALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLV-HFSWQAI 162
Cdd:cd17329  80 ALLGFAHSPWLFAIALV--LTGFGGGLFEPasEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLySFRLLFL 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 163 FATLFAITVVLILpIFWLKPTTKARNNSQDGLTFTDL---LRSKTYRGNVLIYAACSASFFAWLTGSP-FILSEMGYSPA 238
Cdd:cd17329 158 AAAVLFLLAALVL-LFLLPETRPKRRAAEKTEILRGYkivLRDRAFLLFLLASFLISLIYFQLESTLPvYVVEILGLGES 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 49176132 239 VIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAG 289
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFAN 287

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

7-185

3.65e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.12 E-value: 3.65e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   7 FLVWLAGLSVLGFLATDMYLPAFaaIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGR--KPVLLIGLTIFALG 84
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTY--LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  85 SLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFA 164
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341

                       170       180
                ....*....|....*....|.
gi 49176132 165 TLFAITVVLILPIFWLKPTTK 185
Cdd:COG2271 342 LLAALALLAALLALLLLRETR 362

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

48-182

3.80e-11

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 64.25 E-value: 3.80e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  48 SLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQK 127
Cdd:cd17371  41 TVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARH 120

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 49176132 128 VNRIFAAIMPL----VGLSPALAPLLGSWLLVHFSWQAifatLFAITVVLILPIFWLKP 182
Cdd:cd17371 121 RGKALGYVQSGwavgWLLATLLAALLFPLLPPEIAWRV----LFLLGALPALLVLFIRR 175

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

8-377

1.97e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.86 E-value: 1.97e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   8 LVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLI-----GLTIFA 82
Cdd:cd06173   1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  83 LGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAI 162
Cdd:cd06173  81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 163 FATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTY-RGNVLIYAACSASFFAWLTGSP-------FILSEMG 234
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYlRRSPLLRLLLLALALFALLGGAltvllplLAKEVLG 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 235 YSPAVIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMA--IANGA 312
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLfnVPLNT 320

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49176132 313 IYPIVVAQALRpfphatGRAAALQNTLQLGLCFLASLVVSWL---ISISTPLLTTTSVMLSTVVLVAL 377
Cdd:cd06173 321 LLQLRVPDELR------GRVFSVYNALNSGAMPLGALLAGLLadaLGLSAVFLLAGALLLLAALLLLL 382

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

11-182

2.80e-10

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.05 E-value: 2.80e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  11 LAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLW 90
Cdd:cd17330   4 VVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  91 VENAATLLVLRFVQAVGvCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQA--IFATLFA 168
Cdd:cd17330  84 SRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALpfLVAAALA 162

                       170
                ....*....|....
gi 49176132 169 ItVVLILPIFWLKP 182
Cdd:cd17330 163 L-LNLVLVLFFLPP 175

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

2-176

1.25e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 59.48 E-value: 1.25e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   2 QPGKRFLVWLAGLSVLGFLATDMYLPAFAAiqADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIF 81
Cdd:cd17370 197 KLPKAFWLYLLAVALFALGNFSFAFLILRA--QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSL 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  82 ALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQA 161
Cdd:cd17370 275 ALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSA 354

                       170
                ....*....|....*..
gi 49176132 162 --IFATLFAITVVLILP 176
Cdd:cd17370 355 afLFSAVLALIALLLLL 371

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

6-187

1.82e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.15 E-value: 1.82e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   6 RFLVWLAGLSVLGFLATDMYLPAFA-AIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALG 84
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  85 SLGMLWV--ENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNR------IFAAIMPLV-GLSPALAPLLGSWLLV 155
Cdd:COG2211 308 LLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrregLYFGIFTFAiKLGQALAGALAGLLLA 387

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 49176132 156 HFSWQA--------------IFATLFAITVVLILPIFWLKPTTKAR 187
Cdd:COG2211 388 LFGYVAgaaqspsaltgirlLFFLLPAVLLLLAALLLLFYPLTRER 433

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

42-181

9.46e-09

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 56.50 E-value: 9.46e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  42 AVSASLSLFLAGFaaaqllWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTD 121
Cdd:cd17391 247 SATGVSSLLSAPR------LGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK 320

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 122 YYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFatlFAITVVLILPIFWLK 181
Cdd:cd17391 321 ITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVF---VVTALLVLLNAIWSF 377

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

7-187

2.71e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 55.27 E-value: 2.71e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   7 FLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAaaQLLWGPLSDRYGRKPVLLIGLTIFALGSL 86
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALG--RPLGGWLSDRIGGRRVLLIVFALMALGLL 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  87 GMLWVENAATLLVLRFVqAVGVCAAAV--IWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHF-SWQAIF 163
Cdd:COG2223 287 LLALALGSLWLFLVLFL-LLGLALGGGngAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAF 365

                       170       180
                ....*....|....*....|....
gi 49176132 164 ATLFAITVVLILPIFWLKPTTKAR 187
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPRRA 389

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

43-180

3.57e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 54.51 E-value: 3.57e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  43 VSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDY 122
Cdd:cd17317  27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 49176132 123 YPSQKvnRIFAAIMPLVGLSPALAPLLGSWLLVHfSWQAIFATLFAITVVLILPIFWL 180
Cdd:cd17317 107 VGPKY--RSFVGILFGLFWALGYMLLALLAYLIR-DWRWLQLAISLPGLLFLLLLWWL 161

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

7-177

7.79e-08

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.76 E-value: 7.79e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   7 FLVWLAGLSVLGFLATDMYLPAFaaIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGS- 85
Cdd:cd17316 181 LLILLWFFISFGYYGLTTFLPTY--LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAl 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  86 -LGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFA 164
Cdd:cd17316 259 pLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338

                       170
                ....*....|...
gi 49176132 165 TLFAITVVLILPI 177
Cdd:cd17316 339 LILALLAIVALIV 351

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

9-377

2.33e-07

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.16 E-value: 2.33e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   9 VWLAGL-SVLGFLATDMYLPAFAAIQADLQTPASAVS--ASLSLFLAGFAaaQLLWGPLSDRYG-RKPVLLIGLTIFALG 84
Cdd:cd17370   1 VWLLGLvSLFADISYEMARSILPLFLVVLGASAAAVGliEGLAEALGSLL--RLFSGYLSDRTGkRKPLVILGYGLSALA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  85 SLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLL--VHFSWQAI 162
Cdd:cd17370  79 KPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLylLGGNYRTI 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 163 FATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRS----KTYRGNVLIYAACSASF-FAWLTgspfiLSEMGYSP 237
Cdd:cd17370 159 FLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLpkafWLYLLAVALFALGNFSFaFLILR-----AQELGLSA 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 238 AVIGLSYVPQTIAFLIGGYgcraALQKWQGKQLLPWLLVLFAVSVIATwAAGFISHVSLVEILIPFCVMAIANGA---IY 314
Cdd:cd17370 234 ALIPLLYALFNLVYALAAY----PAGRLSDRIGRKKLLILGYLSLALA-YLGFALGSSLWLLLLGFILWGLYMGAqesIE 308

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 49176132 315 PIVVAQALRpfPHATGRAAALQNTLQLGLCFLASLVVSWLI-SISTPLLTTTSVMLSTVVLVAL 377
Cdd:cd17370 309 RAAVADLVP--AELRGTAYGLFNTVVGIGWLLASLIAGYLWdLISPSAAFLFSAVLALIALLLL 370

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

11-321

2.49e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.18 E-value: 2.49e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  11 LAGLSVLGfLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLW 90
Cdd:cd17477   2 LLSVALLG-LGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  91 VENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVhfSWQAIFATLFAIT 170
Cdd:cd17477  81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT--AGALPFLIAAVLL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 171 VVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLtgsPFILSEMGYSPAVIGLSyvpqTIA 250
Cdd:cd17477 159 LLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLL---PLYGLRLGLSVAQAALL----LAA 231

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49176132 251 FLIGGygcrAALQ--------KWQGKQLLPWLLVLFAVSVIATWAAGFISHVslveILIPFCVMAIANGAIYPIVVAQA 321
Cdd:cd17477 232 FVLGG----LLLQwplgwladRFDRRRVLLGCALLGALAALLLPLVPGLPLA----LLVLLFLWGGAAGPLYTLALALA 302

PRK14995

SmvA family efflux MFS transporter;

24-187

6.18e-07

SmvA family efflux MFS transporter;

Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 51.27 E-value: 6.18e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   24 MYLPAfaAIQAD-LQTPASAVSASLSLflagfAAAQLLW----------------GPLSDRYGRKPVLLIGLTIFALGSL 86
Cdd:PRK14995  14 VYIPV--AIDATvLHVAAPTLSMTLGA-----SGNELLWiidiyslvmagmvlpmGALGDRIGFKRLLMLGGTLFGLASL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   87 GMLWVENAATLLVLRFVQAVGvcAAAVIWQAL--VTDYYPSQKVNRIFAAIMPLVG-LSPALAPLLGSWLLVHFSWQAIF 163
Cdd:PRK14995  87 AAAFSPTASWLIATRALLAIG--AAMIVPATLagIRATFTEEKQRNMALGVWAAVGsGGAAFGPLVGGILLEHFYWGSVF 164

                        170       180
                 ....*....|....*....|....
gi 49176132  164 ATLFAITVVLILPIFWLKPTTKAR 187
Cdd:PRK14995 165 LINVPIVLVVMGLTARYVPRQAGR 188

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

17-378

1.14e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.25 E-value: 1.14e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  17 LGFLATDMY----LPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVE 92
Cdd:cd17478   3 LGHFLNDFYqgflPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  93 NAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQK--VNRIFAaimplVG--LSPALAPLLGSWLLVHFSWQAIFATLFA 168
Cdd:cd17478  83 NYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRglAMSIFS-----VGgnLGFALGPLIAAALVALFGGLGLLILLII 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 169 ITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAAC---SASFFAWLTGSPFILSEMGYSPAVIGLS-- 243
Cdd:cd17478 158 PGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVflrSWVLSSLTTFLPFYLVQRGYSLVFAGLLls 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 244 --YVPQTIAFLIGGYgcraALQKWQGKQllpwllVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQA 321
Cdd:cd17478 238 lfLFAGAIGTLIGGP----LSDRFGRRR------VIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLA 307

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 49176132 322 LRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPllttTSVMLSTVVLVALG 378
Cdd:cd17478 308 QELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGL----ESVLLILALLPLLG 360

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

50-253

1.84e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.54 E-value: 1.84e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  50 FLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVN 129
Cdd:cd17328  43 FIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 130 RIFAAIMPLVGLSPALAPLLGSWL-LVHFSWQAIFATLFAITVVLILPIFWLKPT-------TKARNNSQDGLTFTD--- 198
Cdd:cd17328 123 RALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVLLAILLLLFVREpprgaaeGGVMAKSTATSFLADlka 202

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 49176132 199 LLRSKTYrgnVLIYAACSASFFAWLTGSPFILSEMGYSPAVIGLSYVPQTIAFLI 253
Cdd:cd17328 203 LAKNPSF---ILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGA 254

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

28-114

4.27e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 48.33 E-value: 4.27e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  28 AFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVG 107
Cdd:cd17359  23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102


                ....*..
gi 49176132 108 VCAAAVI 114
Cdd:cd17359 103 VGGASAL 109

Sugar_tr

pfam00083

Sugar (and other) transporter;

34-114

4.44e-06

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 48.42 E-value: 4.44e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    34 ADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVL---RFVQAVGVCA 110
Cdd:pfam00083  39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGG 118


                  ....
gi 49176132   111 AAVI 114
Cdd:pfam00083 119 ASVL 122

MFS_ShiA_like

cd17369

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...

39-179

5.18e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 48.29 E-value: 5.18e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  39 PASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWV----ENAATLLVLRFVQAVGVCAAAVI 114
Cdd:cd17369 262 DRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLldtgSTWLIVLAAVVVLGVLHGMMYGP 341

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49176132 115 WQALVTDYYPSQ------KVNRIFAAImplvgLSPALAPLLGSWLLV-HFSWQAIFATLFAITVVLILPIFW 179
Cdd:cd17369 342 QAAFLAELFPTRvrytgaSLGYQLGAI-----LGGGFAPLIATALVAaTGSWWPVALYLAALAVISLVAALF 408

MFS_1

pfam07690

Major Facilitator Superfamily;

5-147

7.92e-06

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 7.92e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132     5 KRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALG 84
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49176132    85 SLGMLWV---ENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAP 147
Cdd:pfam07690 279 ALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344

PRK11551

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional

59-163

1.49e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional

Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 46.88 E-value: 1.49e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   59 LLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPL 138
Cdd:PRK11551  68 LLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCG 147

                         90       100
                 ....*....|....*....|....*
gi 49176132  139 VGLSPALAPLLGSWLLVHFSWQAIF 163
Cdd:PRK11551 148 VPFGGALASVIGVLAAGDAAWRHIF 172

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

48-180

1.70e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 46.93 E-value: 1.70e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    48 SLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQk 127
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKK- 212

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 49176132   128 vNRIFAAIMPLVGLSPALAPLLG-SWLLVHfsWQAIFATLFAITVVLILPIFWL 180
Cdd:TIGR00898 213 -QRAIVGTLIQVFFSLGLVLLPLvAYFIPD--WRWLQLAVSLPTFLFFLLSWFV 263

MFS_MFSD10

cd17389

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...

60-183

3.00e-05

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 45.73 E-value: 3.00e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  60 LWGPLSDRYGRKPVLLigLTIFALG-SLGMLWVENAATLLVL-RFVQavGVCAAAV-IWQALVTDYYPSQKVNRifaaIM 136
Cdd:cd17389  83 ITGAASDVYGRKPVLL--LTMIGLAiSYALWAVSRSFTIFLLsRIVG--GISKGNVsLSTAIVADVTSPKKRSK----GM 154

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 49176132 137 PLVGLSPALA----PLLGSWL--------LVHFSWQAIFATLFAITVVLILPIFwLKPT 183
Cdd:cd17389 155 ALIGVAFSLGfiigPMIGAYFasftrslgEVFFSMPALFALVLALADLLFIFFF-LPET 212

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

40-326

3.13e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.67 E-value: 3.13e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  40 ASAVSASLS---LFLAGFAAAQLLW----GPLSDRYG-RKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQavGVCAA 111
Cdd:cd17490  23 AESLGASLSmigIILGAYGISQMLLriplGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLS--GIAAA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 112 A-VIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIF--ATLFAItVVLILPIFWLKPTTKARN 188
Cdd:cd17490 101 TwVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFllAALAGV-LGFILSLFIKEERREKKP 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 189 NSQDGLTFTDLLRSKtyrgNVLIYAACSASFFAWLTGSPF-----ILSEMGYSPAVIGLSYVPQTIAFLIGGYGCRAALQ 263
Cdd:cd17490 180 VLTELKELLSVLKDK----KLLFFSLLAILQQMITFSTTFgftplIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFY 255

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 49176132 264 KWQGKQLlpWLLVLFAVSVIATWAAGFISHVSLVEILipFCVMAIANGAIYPIVVAQALRPFP 326
Cdd:cd17490 256 KKLGERN--TIIIGFLLLGAYCFLIPFAPNLTLLYLL--QALNGFGTGILFPLLMSLSIEGVP 314

MFS_HMIT_like

cd17360

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...

15-114

3.57e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 45.34 E-value: 3.57e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  15 SVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFaaaqllwgpLSDRYGRKPVLLIGLTIFALGSLGMLWVENA 94
Cdd:cd17360  18 GALLYIKDDLGEVVLSTGWQELIVSSTVAGAAVGAAIGGW---------LNDRFGRRPCILLADALFTIGAIVMAAAPNK 88

                        90       100
                ....*....|....*....|
gi 49176132  95 ATLLVLRFVQAVGVCAAAVI 114
Cdd:cd17360  89 EVLIVGRVLVGLGVGIASMT 108

MFS_FucP_MFSD4_like

cd17333

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...

37-187

4.16e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.39 E-value: 4.16e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  37 QTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQ 116
Cdd:cd17333  27 NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGAN 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49176132 117 ALVTDYYPSqKVNRIFAAIMPLVGLSPALAPLLGSWLL-VHFSWQAIFATLFAItvVLILPIFWLKPTTKAR 187
Cdd:cd17333 107 TFVGALFEE-SSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLI--YLLLAILILLTLFPEL 175

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

48-114

4.23e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 45.26 E-value: 4.23e-05

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49176132  48 SLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVI 114
Cdd:cd17315  41 SSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVL 107

PRK03893

putative sialic acid transporter; Provisional

35-248

4.65e-05

putative sialic acid transporter; Provisional

Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 45.46 E-value: 4.65e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   35 DLQTPASAVSAS-LSLFLAGfaaaqLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAV 113
Cdd:PRK03893  53 TTVQAASLISAAfISRWFGG-----LLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  114 IWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAifatLFAITVVLILPIFWLKPTT------KAR 187
Cdd:PRK03893 128 SSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRA----LFFIGILPIIFALWLRKNLpeaedwKEK 203

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49176132  188 NNSQ--DGLTFTDLLRSKTYRGNVLIYAACSASF---FAWLTGSPFILSEMGYSPAVIGLSYVPQT 248
Cdd:PRK03893 204 HAGKapVRTMVDILYRGEHRIINILLTLAAAAALwfcFAGNLQNAAIVAVLGLLCAAIFISFMVQS 269

MFS_OAT

cd17374

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...

44-180

5.30e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 44.97 E-value: 5.30e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  44 SASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYY 123
Cdd:cd17374  38 SVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWT 117

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 49176132 124 PSQKvnRIFAAIMPLVGLSPALApLLGSWLLVHFSWQAIFATLFAITVVLILPIFWL 180
Cdd:cd17374 118 TPRH--RALAITLTSCFFSIGQM-LLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWL 171

MFS_OFA_like

cd17353

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...

7-175

5.34e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.91 E-value: 5.34e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   7 FLVWLAGLSVLGFLAtDMylpAFAAIQADLQTPASAVSAsLSLFLAGfaaAQLLWGPLSDRYGRKPVLLIGLTIFALGSL 86
Cdd:cd17353 223 FLNATAGLMLIGQAK-PI---GQEFAGLDAGIAALAVSI-LSIFNGG---GRPFWGWLSDKIGRKNTLSIAFLIQGVAMF 294

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  87 GMLWVENAATLLVLrFVQAVGVCAAA--VIWQALVTDYYPSQKvnriFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFA 164
Cdd:cd17353 295 LLPFIGSVAVLFVL-GVALIGFCYGGgfALFPALTADFFGTKN----AGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYN 369

                       170
                ....*....|.
gi 49176132 165 TLFAITVVLIL 175
Cdd:cd17353 370 AAFIIAAALSL 380

MFS_MelB_like

cd17332

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...

8-185

9.37e-05

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.13 E-value: 9.37e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   8 LVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLG 87
Cdd:cd17332 223 FLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLL 302

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  88 MLWVE--NAATLLVLRFVQAVGVCAAAVIWQALVTD------YYPSQKVNRIFAAIMPLVG-LSPALAPLLGSWLLVHFS 158
Cdd:cd17332 303 LFFLPpgNLVLILVLAVLAGIGYGGANLLPWAMLADvidygeLKTGKRREGIFYSVMTFFRkLGLALAGALVGLILSLAG 382

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 49176132 159 WQA------------IFATLFAITVVLIL---PIFWLKPTTK 185
Cdd:cd17332 383 YVAnaaaqsasalngIRLLIAVLPAVLLLlalILMSFYPLDK 424

MFS_OPA_SLC37

cd17312

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...

47-180

1.82e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 1.82e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  47 LSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRF----VQAVGVCAAAViwqaLVTDY 122
Cdd:cd17312  44 GSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGlnglFQSMGWPPCVK----LLGNW 119

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 49176132 123 YPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIFWL 180
Cdd:cd17312 120 FSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFF 177

MFS_FBT

cd17484

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...

56-286

1.86e-04

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 43.37 E-value: 1.86e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  56 AAQLLWGPLSD-----RYGRKPVLLIG--LTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYypSQKV 128
Cdd:cd17484  47 AIKPLYGLLSDsvpifGYRRKPYLILAgaLGALSWLALALVSNSSLALALLLLLLASLGVAFSDVVIDALVVEA--SRGA 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 129 NRIFAA-IMPLVGLSPALAPLLGSW----LLVHFSWQAIFA--TLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLR 201
Cdd:cd17484 125 PQSLAGdLQSLCWGSSAIGGIVGSYfsgyLLELLGPRTVFAvtSFFPLLLLIVAFFVKEERVPPHRTKENFDEQLKALWE 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 202 SKTYRgnvliYAACSASFFAWLTGSPFILSEM--------GYSPAVIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPW 273
Cdd:cd17484 205 TVKQP-----SIWLPALFIFLYQATPSSGSAMfyfmtnelGFSPEFLGRLRVIGSIASLLGVLLYNRFLKHVPFRKIFFW 279

                       250
                ....*....|...
gi 49176132 274 LLVLFAVSVIATW 286
Cdd:cd17484 280 TTVLLVLLGLTDL 292

MFS_Set

cd17471

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...

51-187

2.12e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.12e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  51 LAGFAAAQLLwGPLSDR-YGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFV-QAVGVCAAAVIWqALVTDYYPSQKV 128
Cdd:cd17471  43 LSGIVVSQWL-GRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVlLSLGAAAFPQLF-ALAREYADRSSG 120

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49176132 129 NRI--FAAIM-PLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIFWLKPTTKAR 187
Cdd:cd17471 121 RDAtlFNSVLrAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPP 182

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

29-180

2.53e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 42.75 E-value: 2.53e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    29 FAAIQADLQTPASAVSASLSLFLAGFAAA----QLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQ 104
Cdd:TIGR00881  14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAygisKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49176132   105 AVGVCAAAVIWQALVTDYYPSQKVNRIFA--AIMPLVGLSpALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIFWL 180
Cdd:TIGR00881  94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSfwNCSHNVGGG-LLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLL 170

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

6-179

3.03e-04

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 3.03e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   6 RFLVWLAGLSVLGFLATDMYLPAFAAIqaDLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRY-GRKPVLLIGLTIFALG 84
Cdd:cd06174 206 WLLLLAIFLVNLAYYSFSTLLPLFLLD--LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALG 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  85 SLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFA 164
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363

                       170
                ....*....|....*
gi 49176132 165 TLFAITVVLILPIFW 179
Cdd:cd06174 364 LVLAVLLLLAAILLL 378

MFS_TetA

cd17388

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...

35-189

3.53e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 42.24 E-value: 3.53e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  35 DLQTPASAVSASLSLFLAGFAAAQLLWGP----LSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQ----AV 106
Cdd:cd17388  28 EFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAgitgAT 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 107 GVCAAAVIwqALVTDyyPSQKVNRiFAAIMPLVGLSPALAPLLGSWlLVHFSWQAIFATLFAITVV-LILPIFWLKPTTK 185
Cdd:cd17388 108 GAVAAAYI--ADVTP--PEQRARN-FGLLGAAFGLGFIAGPALGGL-LGEISPRAPFLVAAGLNGLnFLLGLFVLPESLP 181


                ....
gi 49176132 186 ARNN 189
Cdd:cd17388 182 PERR 185

MFS_SLC22A1_2_3

cd17379

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...

52-152

5.36e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 41.57 E-value: 5.36e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  52 AGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQkvNRI 131
Cdd:cd17379  44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSK--YRR 121

                        90       100
                ....*....|....*....|....*..
gi 49176132 132 FAAIMPLVGLS------PALAPLLGSW 152
Cdd:cd17379 122 TVGIVYQMFFTlgllilPGIAYFIPHW 148

MFS_Amf1_MDR_like

cd17476

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...

27-249

5.46e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.86 E-value: 5.46e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  27 PAFAAIQADLQTPASAVSASLSLFLagfaaaqLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAV 106
Cdd:cd17476  26 DSFGTSPNQLSWLAASYSLTVGTFI-------LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 107 GvcAAAVIWQA---LVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVL-ILPIFWLKP 182
Cdd:cd17476  99 G--PAFLLPNAmalLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVaVAAIFWTSP 176

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49176132 183 TTKARnnsqdgltftdllrsktyrgnVLIYAACSASFFAWL-TGSPFILSEMGYSPAVIGLSYVPQTI 249
Cdd:cd17476 177 SFIAV---------------------LLAVFLGWASFGIWVfYATQYFQNVRGYSPLLTSARFIPMAI 223

MFS_MT3072_like

cd17475

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...

32-172

6.07e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.84 E-value: 6.07e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  32 IQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAA 111
Cdd:cd17475  22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49176132 112 AVIWQALVTDYYPSQKvnRIFAaiMPL----VGLSPALAPLLGSWLLVHFSWQAIFATLFAITVV 172
Cdd:cd17475 102 QPGGGRAIMRWFPPRE--RGLA--MGIrqtgVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIL 162

MFS_SLC22A18

cd17331

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...

11-178

6.48e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.44 E-value: 6.48e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  11 LAGLSVLGFLATDMYLPAFAAIQAD-LQTPASAVSASLSLF-LAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGM 88
Cdd:cd17331 212 LLLVKLLSGLPIGMFQSMFSLVAMDfFGLTPEENGYLMSYAgVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLL 291

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  89 LWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFA 168
Cdd:cd17331 292 AFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAA 371

                       170
                ....*....|
gi 49176132 169 ITVVLILPIF 178
Cdd:cd17331 372 INGLLTVYLL 381

MFS_SLC17A9_like

cd17380

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...

47-179

7.24e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.39 E-value: 7.24e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  47 LSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAAT--LLVLRFVQAV--GVCAAAVIWqaLVTDY 122
Cdd:cd17380  40 LSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLplLILSRILLGLgeGVHFPSMTS--LFSRW 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 49176132 123 YPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIF------ATLFAITVVLILPIFW 179
Cdd:cd17380 118 VPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFyffgllGLLWALVWLIYLPPVW 180

MFS_YjiJ

cd06180

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...

25-384

8.30e-04

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 41.14 E-value: 8.30e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  25 YLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQ 104
Cdd:cd06180  18 YTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLA 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 105 AVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVH-FSWQAIFATLFAITVVLILPIFWLKPT 183
Cdd:cd06180  98 GAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLALALLSAVLLLLSFLLLRR 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 184 TKARNNSQDGLTFTDLLRSKTYRgNVLIYAACSASFFAWLTGSPFILSEMGYSPAVIGLSYVPQTIAFLIGGYGCRAALQ 263
Cdd:cd06180 178 GPSAPTEASAAESAPGLNRPLWR-LALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSD 256

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 264 KWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANgaiypIVVAQALRPFPHATGRAAALQNTLQLGL 343
Cdd:cd06180 257 RWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITA-----LVMALARELAPPAAPRALALMTASFGVG 331

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 49176132 344 CFLASLVVSWLISISTPLltTTSVMLSTVVLVALGYMMQRC 384
Cdd:cd06180 332 QILGPLLAGWLADATGGF--APALILAAAALVVAALLALLV 370

MFS_TRI12_like

cd06179

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...

27-190

9.30e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.46 E-value: 9.30e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  27 PAFAAIQADLQTPASAVSASLSLFLAGfAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAV 106
Cdd:cd06179  19 AVLPFIVADLGPSSNSTWISTAWSLAQ-AVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 107 GVcAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLV--HFSWQAIF---ATLFAITVVLILPIFWLK 181
Cdd:cd06179  98 GA-GTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFyinAIFNALALILLFFFYHPP 176


                ....*....
gi 49176132 182 PTTKARNNS 190
Cdd:cd06179 177 PRPQLHGSS 185

MFS_KgtP

cd17367

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...

11-109

1.05e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 41.13 E-value: 1.05e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  11 LAGLSVLGFLATDMYLPAFAAIQADLqtPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLW 90
Cdd:cd17367 231 LTAGGTLAFYTWTTYLQKFLVNTAGF--SKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLS 308

                        90       100
                ....*....|....*....|
gi 49176132  91 -VENAATLLVLRFVQAVGVC 109
Cdd:cd17367 309 aLDHTDSPYTAFALVLVGLV 328

TRI12

pfam06609

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...

6-187

1.30e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.

Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 40.81 E-value: 1.30e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132     6 RFLVWLAGLSvLGFLATDMYLPAFA-AIQADLQTPASAVSASL--SLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFA 82
Cdd:pfam06609  41 RIIASFAAFS-LNVCATYFVLQASAsALPNILQDIGQSENQGLfsTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    83 LGSLGMLWVENAATLLVLrfVQAVGVCAAAVIWQALVTDYYPSQKVN--RIFAAIMPLVGLSpALAPLLGSWLLVHFSWQ 160
Cdd:pfam06609 120 VGAIVGCTANKFNTLLAA--MTLLGVAAGPAGASPLFIGELMSNKTKflGLLIVSAPTIAMN-GAGPYFGQRLAIQGNWR 196

                         170       180
                  ....*....|....*....|....*...
gi 49176132   161 AIFAT-LFAITVVLILPIFWLKPTTKAR 187
Cdd:pfam06609 197 WIFYIyIIMSAIAVLLIIIWYHPPSFAQ 224

MFS_ProP

cd17366

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...

38-104

1.82e-03

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 40.03 E-value: 1.82e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  38 TPASAVSASLSLFLAGFAAAQLL-------WGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAAT--------LLVLRF 102
Cdd:cd17366  30 FPGGDPTAQLLATFATFAVAFLVrplgglvFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATigvwapilLLLARM 109


                ..
gi 49176132 103 VQ 104
Cdd:cd17366 110 VQ 111

MFS_SLC22A15

cd17377

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...

40-85

1.89e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 40.15 E-value: 1.89e-03

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 49176132  40 ASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGL---TIFALGS 85
Cdd:cd17377  38 AYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLaldILFAYFN 86

MFS_YjiJ

cd06180

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...

13-175

2.13e-03

Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.98 E-value: 2.13e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  13 GLSVLGFLATDMYLPAFAAiqadlQTPASAVSASLSLFLAGFAAAQ--LLWGPLSDRYGRKPVLLIGLTIFALGSLGMLW 90
Cdd:cd06180 206 GLFGFGYIITATFLPLIAR-----ETGAGSLLAGLLWSLFGLAAVPscFLWGALSDRWGTRRALAANLLVQAVGVLLPLL 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  91 VENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPsQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSwqAIFATLFAIT 170
Cdd:cd06180 281 SPGPAGLVLSAVLFGGTFMAITALVMALARELAP-PAAPRALALMTASFGVGQILGPLLAGWLADATG--GFAPALILAA 357


                ....*
gi 49176132 171 VVLIL 175
Cdd:cd06180 358 AALVV 362

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

5-187

2.28e-03

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.84 E-value: 2.28e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   5 KRFLVWLAGLSVLGFLATDMYLPAFAAI--QADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFA 82
Cdd:COG0738 208 KNPRLLLGGLAIFLYVGAEGAIGDWLPLylKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAA 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  83 LGSLGMLWVENAATLLVlrFVQAVGVCAAaVIW---QALVTDYYPSQKVNRIfAAIMPLVGLSPALAPLLGSWLLVHFSW 159
Cdd:COG0738 288 VGLLLALLAPGPWLALI--GLALVGLGLS-LMFptiFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGL 363

                       170       180
                ....*....|....*....|....*...
gi 49176132 160 QAIFATLFAITVVLILPIFWLKPTTKAR 187
Cdd:COG0738 364 RAAFLVPLVCYLLILLLALALKRKRRKK 391

MFS_GLUT_Class1_2_like

cd17357

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...

44-185

2.46e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.94 E-value: 2.46e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  44 SASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGML---WVENAATLLVLRFVqaVGVCAAAVI-WQAL- 118
Cdd:cd17357  52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFlskSAKSPELLIFGRFL--VGIACGLSTgFVPMy 129

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 49176132 119 VTDYYPSQ------KVNRIFAAIMPLVGLSPALAPLLGSWLLvhfsWQAIFATLFAITVVLILPIFWLKPTTK 185
Cdd:cd17357 130 LQEISPSElrgalgSLTQIGVTLGILLGQVFGLPSVLGTETL----WPYLLFFPGIPALLQLAALPFFPESPK 198

MFS_OFA_like

cd17353

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...

5-319

2.76e-03

Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 2.76e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   5 KRFLVWLAGLSVLGFLATDMYLPAFA-AIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFAL 83
Cdd:cd17353   1 RRWLVLLGAVLMHLILGYQYAWSVFNpPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  84 GSLGM-LWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPlVGLSPALAPLLGSWLLVHFSWQAI 162
Cdd:cd17353  81 GFILSaFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAG-FGLGSLIFSPLIAYLINTVGVPTT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 163 FATLFAITVVLILPIFWL-------------KPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYA-ACSASFFAWLTGSPF 228
Cdd:cd17353 160 FLILGIIFLIIIVIGAFLirdppkgwvppgvDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFlNATAGLMLIGQAKPI 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132 229 ILSEMGYSPAVIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLlpwLLVLFAVSVIATWAAGFISHVsLVEILIPFCVMAI 308
Cdd:cd17353 240 GQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNT---LSIAFLIQGVAMFLLPFIGSV-AVLFVLGVALIGF 315

                       330
                ....*....|.
gi 49176132 309 ANGAIYPIVVA 319
Cdd:cd17353 316 CYGGGFALFPA 326

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

6-180

3.05e-03

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.52 E-value: 3.05e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   6 RFLVWLAGLSVLGFLA---TDMYLPAFAAIQADLqtPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFA 82
Cdd:cd17329 200 RAFLLFLLASFLISLIyfqLESTLPVYVVEILGL--GESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFA 277

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  83 LGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAI 162
Cdd:cd17329 278 IGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLP 357

                       170
                ....*....|....*...
gi 49176132 163 FATLFAITVVLILPIFWL 180
Cdd:cd17329 358 WLILAALGLIAAALLLGL 375

MFS_ShiA_like

cd17369

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...

39-108

3.07e-03

Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.43 E-value: 3.07e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  39 PASAVSASLSLFLAGFAAAQL---LWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAAT--------LLVLRFVQAVG 107
Cdd:cd17369  39 PAAGTLAAFATFGVGFLARPLggvVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLA 118


                .
gi 49176132 108 V 108
Cdd:cd17369 119 L 119

synapt_SV2

TIGR01299

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...

16-111

3.52e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.

Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.57 E-value: 3.52e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132    16 VLGFLatdmyLPAfaaIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAA 95
Cdd:TIGR01299 185 VVGFV-----LPS---AEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYG 256

                          90
                  ....*....|....*.
gi 49176132    96 TLLVLRFVQAVGVCAA 111
Cdd:TIGR01299 257 FFLFCRLLSGFGIGGA 272

PRK10504

putative transporter; Provisional

62-182

4.18e-03

putative transporter; Provisional

Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 39.33 E-value: 4.18e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132   62 GPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKvnriFAAIMPLVGL 141
Cdd:PRK10504  66 GWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQ----YMAAMTFVTL 141

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 49176132  142 ----SPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIFWLKP 182
Cdd:PRK10504 142 pgqvGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMP 186

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

41-181

4.69e-03

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.78 E-value: 4.69e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176132  41 SAVSASLSLFLAGFAAAqlLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAV--GVCAAAViwqAL 118
Cdd:cd17391  38 SGLAFSSTFLVSAIFSP--IWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVfsGYVPNAT---AL 112

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 49176132 119 VTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIF-ATLFAITVVLILPIFWLK 181
Cdd:cd17391 113 IASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFfITGGLLFLAFLLTLFFVK 176

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01