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Conserved domains on  [gi|49176374|ref|YP_026231|]
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valine--pyruvate aminotransferase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

pyridoxal phosphate-dependent aminotransferase( domain architecture ID 11484172)

pyridoxal phosphate (PLP)-dependent aminotransferase catalyzes the reversible exchange of an amino group from one molecule with a keto group from another molecule, an important reaction in the synthesis of amino acids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
avtA PRK09440
valine--pyruvate transaminase; Provisional
 1-416 0e+00

valine--pyruvate transaminase; Provisional


:

Pssm-ID: 236517  Cd Length: 416  Bit Score: 857.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374    1 MTFSLFGDKFTRHSGITLLMEDLNDGLRTPGAIMLGGGNPAQIPEMQDYFQTLLTDMLESGKATDALCNYDGPQGKTELL 80
Cdd:PRK09440   1 MQFSKFGEKFTRHSGITQLMDDLNDGLRTPGAIMLGGGNPAHIPEMEDYFRDLLADLLASGKLTEALGNYDGPQGKDELI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   81 TLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLAPEYIGYADAGLEEDLFVSARPNIELL 160
Cdd:PRK09440  81 EALAALLNERYGWNISPQNIALTNGSQSAFFYLFNLFAGRRADGSLKKILFPLAPEYIGYADAGLEEDLFVSYRPNIELL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  161 PEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGVPFPGIIFSEARPLWNPN 240
Cdd:PRK09440 161 PEGQFKYHVDFEHLHIDEDTGAICVSRPTNPTGNVLTDEELEKLDALARQHNIPLLIDNAYGPPFPGIIFSEATPLWNPN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  241 IVLCMSLSKLGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEMIKRNDLLRLSETVIKPFYYQRVQETIAI 320
Cdd:PRK09440 241 IILCMSLSKLGLPGVRCGIVIADEEIIEALSNMNGIISLAPGRLGPAIAAEMIESGDLLRLSETVIRPFYRQKVQLAIAL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  321 IRRYLPENRCLIHKPEGAIFLWLWFKDLPITTKQLYQRLKARGVLMVPGHNFFPGLDKPWPHTHQCMRMNYVPEPEKIEA 400
Cdd:PRK09440 321 LRRYLPDEPCLIHKPEGAIFLWLWFKDLPITTEELYQRLKARGVLVVPGHYFFPGLDEDWPHAHQCIRMNYVQDDEEIEK 400

                        410
                 ....*....|....*.
gi 49176374  401 GVKILAEEIERAWAES 416
Cdd:PRK09440 401 GIAILAEEVEKAYAES 416
 
Name Accession Description Interval E-value
avtA PRK09440
valine--pyruvate transaminase; Provisional
 1-416 0e+00

valine--pyruvate transaminase; Provisional


Pssm-ID: 236517  Cd Length: 416  Bit Score: 857.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374    1 MTFSLFGDKFTRHSGITLLMEDLNDGLRTPGAIMLGGGNPAQIPEMQDYFQTLLTDMLESGKATDALCNYDGPQGKTELL 80
Cdd:PRK09440   1 MQFSKFGEKFTRHSGITQLMDDLNDGLRTPGAIMLGGGNPAHIPEMEDYFRDLLADLLASGKLTEALGNYDGPQGKDELI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   81 TLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLAPEYIGYADAGLEEDLFVSARPNIELL 160
Cdd:PRK09440  81 EALAALLNERYGWNISPQNIALTNGSQSAFFYLFNLFAGRRADGSLKKILFPLAPEYIGYADAGLEEDLFVSYRPNIELL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  161 PEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGVPFPGIIFSEARPLWNPN 240
Cdd:PRK09440 161 PEGQFKYHVDFEHLHIDEDTGAICVSRPTNPTGNVLTDEELEKLDALARQHNIPLLIDNAYGPPFPGIIFSEATPLWNPN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  241 IVLCMSLSKLGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEMIKRNDLLRLSETVIKPFYYQRVQETIAI 320
Cdd:PRK09440 241 IILCMSLSKLGLPGVRCGIVIADEEIIEALSNMNGIISLAPGRLGPAIAAEMIESGDLLRLSETVIRPFYRQKVQLAIAL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  321 IRRYLPENRCLIHKPEGAIFLWLWFKDLPITTKQLYQRLKARGVLMVPGHNFFPGLDKPWPHTHQCMRMNYVPEPEKIEA 400
Cdd:PRK09440 321 LRRYLPDEPCLIHKPEGAIFLWLWFKDLPITTEELYQRLKARGVLVVPGHYFFPGLDEDWPHAHQCIRMNYVQDDEEIEK 400

                        410
                 ....*....|....*.
gi 49176374  401 GVKILAEEIERAWAES 416
Cdd:PRK09440 401 GIAILAEEVEKAYAES 416
AvtA COG3977
Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and ...
 3-415 0e+00

Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism];


Pssm-ID: 443176  Cd Length: 414  Bit Score: 813.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   3 FSLFGDKFTRHSGITLLMEDLNDGLRT-PGAIMLGGGNPAQIPEMQDYFQTLLTDMLESGKATDALCNYDGPQGKTELLT 81
Cdd:COG3977   1 LSQFGEKFTRLTGIRQLMDDLGEALRSgPDMIMLGGGNPAIIPEVEQLFRDCLAELLASGELGELVGNYDSPQGKDPFIE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  82 LLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLAPEYIGYADAGLEEDLFVSARPNIELLP 161
Cdd:COG3977  81 ALAKLLNQRYGWNLTPENIALTNGSQSAFFYLFNLFAGRTADGSLKKILLPLAPEYIGYADAGLEPDLFVAYKPTIELLD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 162 EGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGVPFPGIIFSEARPLWNPNI 241
Cdd:COG3977 161 DHLFKYHVDFEQLEIDEDTGAICVSRPTNPTGNVLTDEELARLDELARQHNIPLIIDNAYGPPFPNIIFTEATPIWNENI 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 242 VLCMSLSKLGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEMIKRNDLLRLSETVIKPFYYQRVQETIAII 321
Cdd:COG3977 241 ILCMSLSKLGLPGERTGIVIADEEIIQALSNFNTIISLAPGRLGPALAAELIESGDLLRLSENVIRPFYQQKAEVAVATL 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 322 RRYLPENRCLIHKPEGAIFLWLWFKDLPITTKQLYQRLKARGVLMVPGHNFFPGLDKPWPHTHQCMRMNYVPEPEKIEAG 401
Cdd:COG3977 321 RRALPDLPWRIHKPEGAIFLWLWFKDLPISSQELYQRLKARGVLVVPGHYFFPGLDEDWPHTHECIRISYTQDDEEIERG 400

                       410
                ....*....|....
gi 49176374 402 VKILAEEIERAWAE 415
Cdd:COG3977 401 IQILAEEVRRAYAE 414
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 69-407 1.32e-47

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 165.98  E-value: 1.32e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  69 NYDGPQGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRadgrvKKVLFPlAPEYIGYadagleED 148
Cdd:cd00609  31 GYYPDPGLPELREAIAEWLGRRGGVDVPPEEIVVTNGAQEALSLLLRALLNPG-----DEVLVP-DPTYPGY------EA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 149 LFVSARPNIE---LLPEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAY---- 221
Cdd:cd00609  99 AARLAGAEVVpvpLDEEGGFLLDLELLEAAKTPKTKLLYLNNPNNPTGAVLSEEELEELAELAKKHGILIISDEAYaelv 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 222 --GVPFPGIIFSEARplwnPNIVLCMSLSK-LGLPGSRCGIIIAN-EKIITAITNMNGIISLAPGGIGPAMMCEMIKRND 297
Cdd:cd00609 179 ydGEPPPALALLDAY----ERVIVLRSFSKtFGLPGLRIGYLIAPpEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGE 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 298 --LLRLSETVIKpfyyqRVQETIAIIRRYLPEnrcLIHKPEGAIFLWLWFKDlPITTKQLYQRLKARGVLMVPGHNFFPG 375
Cdd:cd00609 255 ehLEELRERYRR-----RRDALLEALKELGPL---VVVKPSGGFFLWLDLPE-GDDEEFLERLLLEAGVVVRPGSAFGEG 325

                       330       340       350
                ....*....|....*....|....*....|..
gi 49176374 376 LDKpwphthqCMRMNYVPEPEKIEAGVKILAE 407
Cdd:cd00609 326 GEG-------FVRLSFATPEEELEEALERLAE 350
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
69-372 5.55e-22

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 96.22  E-value: 5.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374    69 NYDGPQGKTELLTLLAGMLREKLGWDIEPQ-NIALTNGSQSAFFYLFNLFAGRradGRVkkVLFPlAPEYIGYAD----A 143
Cdd:pfam00155  34 LYGPTDGHPELREALAKFLGRSPVLKLDREaAVVFGSGAGANIEALIFLLANP---GDA--ILVP-APTYASYIRiarlA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   144 GLEedlFVSarpnIELLPEGQFkyHVDFEHL--HIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAY 221
Cdd:pfam00155 108 GGE---VVR----YPLYDSNDF--HLDFDALeaALKEKPKVVLHTSPHNPTGTVATLEELEKLLDLAKEHNILLLVDEAY 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   222 GV-PFPGIIFSEARPLWN--PNIVLCMSLSK-LGLPGSRCGIIIANEKIITAITNMngiislAPGGIGPAMMCEMIK--- 294
Cdd:pfam00155 179 AGfVFGSPDAVATRALLAegPNLLVVGSFSKaFGLAGWRVGYILGNAAVISQLRKL------ARPFYSSTHLQAAAAaal 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   295 RNDLLRLSETvikPFYYQRVQETIAIIRRYLPENRcLIH-KPEGAIFLWLWFKdlPITTKQLYQRLKAR-GVLMVPGHNF 372
Cdd:pfam00155 253 SDPLLVASEL---EEMRQRIKERRDYLRDGLQAAG-LSVlPSQAGFFLLTGLD--PETAKELAQVLLEEvGVYVTPGSSP 326
tyr_nico_aTase TIGR01265
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ...
 56-343 3.32e-13

tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.


Pssm-ID: 188123  Cd Length: 403  Bit Score: 70.83  E-value: 3.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374    56 DMLESGKATdalcNYDGPQGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLap 135
Cdd:TIGR01265  59 DALRSGKFN----GYAPSVGALAAREAVAEYLSSDLPGKLTADDVVLTSGCSQAIEICIEALANPGANILVPRPGFPL-- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   136 eYIGYADA-GLEEDLFvsarpniELLPEGQFKyhVDFEHLH--IGEETGMICVSRPTNPTGNVITDEELLKLDALANQHG 212
Cdd:TIGR01265 133 -YDTRAAFsGLEVRLY-------DLLPEKDWE--IDLDGLEslADEKTVAIVVINPSNPCGSVFSRDHLQKIAEVAEKLG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   213 IPLVIDNAYG------VPF-PGIIFSEARPlwnpnIVLCMSLSK-LGLPGSRCGIIIANE-------KIITAITNMNGII 277
Cdd:TIGR01265 203 IPIIADEIYGhmvfgdAPFiPMASFASIVP-----VLSLGGISKrWVVPGWRLGWIIIHDphgifrdTVLQGLKNLLQRI 277

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49176374   278 sLAPGGIGPAMMCEMIKRNDLLRLSETVIKpfyyqrVQETIAIIRRYLPENRCLI-HKPEGAIFLWL 343
Cdd:TIGR01265 278 -LGPATIVQGALPDILENTPQEFFDGKISV------LKSNAELCYEELKDIPGLVcPKPEGAMYLMV 337
 
Name Accession Description Interval E-value
avtA PRK09440
valine--pyruvate transaminase; Provisional
 1-416 0e+00

valine--pyruvate transaminase; Provisional


Pssm-ID: 236517  Cd Length: 416  Bit Score: 857.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374    1 MTFSLFGDKFTRHSGITLLMEDLNDGLRTPGAIMLGGGNPAQIPEMQDYFQTLLTDMLESGKATDALCNYDGPQGKTELL 80
Cdd:PRK09440   1 MQFSKFGEKFTRHSGITQLMDDLNDGLRTPGAIMLGGGNPAHIPEMEDYFRDLLADLLASGKLTEALGNYDGPQGKDELI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   81 TLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLAPEYIGYADAGLEEDLFVSARPNIELL 160
Cdd:PRK09440  81 EALAALLNERYGWNISPQNIALTNGSQSAFFYLFNLFAGRRADGSLKKILFPLAPEYIGYADAGLEEDLFVSYRPNIELL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  161 PEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGVPFPGIIFSEARPLWNPN 240
Cdd:PRK09440 161 PEGQFKYHVDFEHLHIDEDTGAICVSRPTNPTGNVLTDEELEKLDALARQHNIPLLIDNAYGPPFPGIIFSEATPLWNPN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  241 IVLCMSLSKLGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEMIKRNDLLRLSETVIKPFYYQRVQETIAI 320
Cdd:PRK09440 241 IILCMSLSKLGLPGVRCGIVIADEEIIEALSNMNGIISLAPGRLGPAIAAEMIESGDLLRLSETVIRPFYRQKVQLAIAL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  321 IRRYLPENRCLIHKPEGAIFLWLWFKDLPITTKQLYQRLKARGVLMVPGHNFFPGLDKPWPHTHQCMRMNYVPEPEKIEA 400
Cdd:PRK09440 321 LRRYLPDEPCLIHKPEGAIFLWLWFKDLPITTEELYQRLKARGVLVVPGHYFFPGLDEDWPHAHQCIRMNYVQDDEEIEK 400

                        410
                 ....*....|....*.
gi 49176374  401 GVKILAEEIERAWAES 416
Cdd:PRK09440 401 GIAILAEEVEKAYAES 416
AvtA COG3977
Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and ...
 3-415 0e+00

Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism];


Pssm-ID: 443176  Cd Length: 414  Bit Score: 813.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   3 FSLFGDKFTRHSGITLLMEDLNDGLRT-PGAIMLGGGNPAQIPEMQDYFQTLLTDMLESGKATDALCNYDGPQGKTELLT 81
Cdd:COG3977   1 LSQFGEKFTRLTGIRQLMDDLGEALRSgPDMIMLGGGNPAIIPEVEQLFRDCLAELLASGELGELVGNYDSPQGKDPFIE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  82 LLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLAPEYIGYADAGLEEDLFVSARPNIELLP 161
Cdd:COG3977  81 ALAKLLNQRYGWNLTPENIALTNGSQSAFFYLFNLFAGRTADGSLKKILLPLAPEYIGYADAGLEPDLFVAYKPTIELLD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 162 EGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGVPFPGIIFSEARPLWNPNI 241
Cdd:COG3977 161 DHLFKYHVDFEQLEIDEDTGAICVSRPTNPTGNVLTDEELARLDELARQHNIPLIIDNAYGPPFPNIIFTEATPIWNENI 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 242 VLCMSLSKLGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEMIKRNDLLRLSETVIKPFYYQRVQETIAII 321
Cdd:COG3977 241 ILCMSLSKLGLPGERTGIVIADEEIIQALSNFNTIISLAPGRLGPALAAELIESGDLLRLSENVIRPFYQQKAEVAVATL 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 322 RRYLPENRCLIHKPEGAIFLWLWFKDLPITTKQLYQRLKARGVLMVPGHNFFPGLDKPWPHTHQCMRMNYVPEPEKIEAG 401
Cdd:COG3977 321 RRALPDLPWRIHKPEGAIFLWLWFKDLPISSQELYQRLKARGVLVVPGHYFFPGLDEDWPHTHECIRISYTQDDEEIERG 400

                       410
                ....*....|....
gi 49176374 402 VKILAEEIERAWAE 415
Cdd:COG3977 401 IQILAEEVRRAYAE 414
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 69-407 1.32e-47

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 165.98  E-value: 1.32e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  69 NYDGPQGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRadgrvKKVLFPlAPEYIGYadagleED 148
Cdd:cd00609  31 GYYPDPGLPELREAIAEWLGRRGGVDVPPEEIVVTNGAQEALSLLLRALLNPG-----DEVLVP-DPTYPGY------EA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 149 LFVSARPNIE---LLPEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAY---- 221
Cdd:cd00609  99 AARLAGAEVVpvpLDEEGGFLLDLELLEAAKTPKTKLLYLNNPNNPTGAVLSEEELEELAELAKKHGILIISDEAYaelv 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 222 --GVPFPGIIFSEARplwnPNIVLCMSLSK-LGLPGSRCGIIIAN-EKIITAITNMNGIISLAPGGIGPAMMCEMIKRND 297
Cdd:cd00609 179 ydGEPPPALALLDAY----ERVIVLRSFSKtFGLPGLRIGYLIAPpEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGE 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 298 --LLRLSETVIKpfyyqRVQETIAIIRRYLPEnrcLIHKPEGAIFLWLWFKDlPITTKQLYQRLKARGVLMVPGHNFFPG 375
Cdd:cd00609 255 ehLEELRERYRR-----RRDALLEALKELGPL---VVVKPSGGFFLWLDLPE-GDDEEFLERLLLEAGVVVRPGSAFGEG 325

                       330       340       350
                ....*....|....*....|....*....|..
gi 49176374 376 LDKpwphthqCMRMNYVPEPEKIEAGVKILAE 407
Cdd:cd00609 326 GEG-------FVRLSFATPEEELEEALERLAE 350
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 28-412 1.52e-35

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 136.50  E-value: 1.52e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  28 RTPGAIMLGGGNPAQ----IPEMQDYFQTLLTDmlesgkATDALCNYDGPQGKTELLTLLAGMLREkLGWDIEPQNIALT 103
Cdd:COG1167 104 AAPGVIDLGSGAPDPdlfpLAALRRALRRALRR------LPPALLGYGDPQGLPELREAIARYLAR-RGVPASPDQILIT 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 104 NGSQSAFFYLFNLFAGRradGRVkkVLFplapEYIGYADAgleEDLFVSARPNIELLP---EGqfkyhVDFEHLHIGEET 180
Cdd:COG1167 177 SGAQQALDLALRALLRP---GDT--VAV----ESPTYPGA---LAALRAAGLRLVPVPvdeDG-----LDLDALEAALRR 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 181 G---MICVSrPT--NPTGNVITDEELLKLDALANQHGIPLVIDNAYGvPFPgiiFSEARP-----LWNPNIVLCM-SLSK 249
Cdd:COG1167 240 HrprAVYVT-PShqNPTGATMSLERRRALLELARRHGVPIIEDDYDS-ELR---YDGRPPpplaaLDAPGRVIYIgSFSK 314

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 250 LGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEMIKRNDLLRLSETVIKpFYYQRVQETIAIIRRYLPEnR 329
Cdd:COG1167 315 TLAPGLRLGYLVAPGRLIERLARLKRATDLGTSPLTQLALAEFLESGHYDRHLRRLRR-EYRARRDLLLAALARHLPD-G 392

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 330 CLIHKPEGAIFLWLWFKDlPITTKQLYQRLKARGVLMVPGHNFFPGldkpwPHTHQCMRMNY-VPEPEKIEAGVKILAEE 408
Cdd:COG1167 393 LRVTGPPGGLHLWLELPE-GVDAEALAAAALARGILVAPGSAFSAD-----GPPRNGLRLGFgAPSEEELEEALRRLAEL 466


                ....
gi 49176374 409 IERA 412
Cdd:COG1167 467 LREL 470
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 70-411 1.91e-35

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 134.49  E-value: 1.91e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  70 YDGPQGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLF--AGrraDgrvkKVLFPlAPEYIGYADAGLee 147
Cdd:COG0436  63 YTPSAGIPELREAIAAYYKRRYGVDLDPDEILVTNGAKEALALALLALlnPG---D----EVLVP-DPGYPSYRAAVR-- 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 148 dlFVSARP-NIELLPEGQFKyhVDFEHL--HIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGvp 224
Cdd:COG0436 133 --LAGGKPvPVPLDEENGFL--PDPEALeaAITPRTKAIVLNSPNNPTGAVYSREELEALAELAREHDLLVISDEIYE-- 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 225 fpGIIFSEARPL-------WNPNIVLCMSLSK-LGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEmikrn 296
Cdd:COG0436 207 --ELVYDGAEHVsilslpgLKDRTIVINSFSKsYAMTGWRIGYAVGPPELIAALLKLQSNLTSCAPTPAQYAAAA----- 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 297 dLLRLSETvikpfYYQRVQETIAIIRRY----LPENRCLIHKPEGAIFLWLWFKDLPITTKQLYQRL-KARGVLMVPGHN 371
Cdd:COG0436 280 -ALEGPQD-----YVEEMRAEYRRRRDLlvegLNEIGLSVVKPEGAFYLFADVPELGLDSEEFAERLlEEAGVAVVPGSA 353

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 49176374 372 FFpgldkpwPHTHQCMRMNYVPEPEKIEAGVKILAEEIER 411
Cdd:COG0436 354 FG-------PAGEGYVRISYATSEERLEEALERLARFLER 386
HisC COG0079
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ...
 87-407 2.18e-23

Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 439849 [Multi-domain]  Cd Length: 341  Bit Score: 100.21  E-value: 2.18e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  87 LREKLG--WDIEPQNIALTNGSQSAFFYLFNLFAGRRadgrvKKVLFPlAPEYIGYADA----GLEEDlFVSARPNiell 160
Cdd:COG0079  53 LREALAeyYGVPPEQVLVGNGSDELIQLLARAFLGPG-----DEVLVP-EPTFSEYPIAaraaGAEVV-EVPLDED---- 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 161 pegqfkYHVDFEHL--HIGEETGMICVSRPTNPTGNVITDEELLKLdALANQHGIPLVIDNAYgVPFPGIIFSeARPLWN 238
Cdd:COG0079 122 ------FSLDLDALlaAITERTDLVFLCNPNNPTGTLLPREELEAL-LEALPADGLVVVDEAY-AEFVPEEDS-ALPLLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 239 --PNIVLCMSLSKL-GLPGSRCGIIIANEKIITAIT------NMNGiISLApggIGPAMMcemikrNDLLRLSETVikpf 309
Cdd:COG0079 193 ryPNLVVLRTFSKAyGLAGLRLGYAIASPELIAALRrvrgpwNVNS-LAQA---AALAAL------EDRAYLEETR---- 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 310 yyQRVQETIAIIRRYLPENRCLIHKPEgAIFLWLwfkDLPITTKQLYQRLKARGVLMVPGHNFfpGLDkpwphthQCMRM 389
Cdd:COG0079 259 --ARLRAERERLAAALRALGLTVYPSQ-ANFVLV---RVPEDAAELFEALLERGILVRDFSSF--GLP-------DYLRI 323

                       330
                ....*....|....*...
gi 49176374 390 NyVPEPEKIEAGVKILAE 407
Cdd:COG0079 324 T-VGTPEENDRLLAALKE 340
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
69-372 5.55e-22

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 96.22  E-value: 5.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374    69 NYDGPQGKTELLTLLAGMLREKLGWDIEPQ-NIALTNGSQSAFFYLFNLFAGRradGRVkkVLFPlAPEYIGYAD----A 143
Cdd:pfam00155  34 LYGPTDGHPELREALAKFLGRSPVLKLDREaAVVFGSGAGANIEALIFLLANP---GDA--ILVP-APTYASYIRiarlA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   144 GLEedlFVSarpnIELLPEGQFkyHVDFEHL--HIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAY 221
Cdd:pfam00155 108 GGE---VVR----YPLYDSNDF--HLDFDALeaALKEKPKVVLHTSPHNPTGTVATLEELEKLLDLAKEHNILLLVDEAY 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   222 GV-PFPGIIFSEARPLWN--PNIVLCMSLSK-LGLPGSRCGIIIANEKIITAITNMngiislAPGGIGPAMMCEMIK--- 294
Cdd:pfam00155 179 AGfVFGSPDAVATRALLAegPNLLVVGSFSKaFGLAGWRVGYILGNAAVISQLRKL------ARPFYSSTHLQAAAAaal 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   295 RNDLLRLSETvikPFYYQRVQETIAIIRRYLPENRcLIH-KPEGAIFLWLWFKdlPITTKQLYQRLKAR-GVLMVPGHNF 372
Cdd:pfam00155 253 SDPLLVASEL---EEMRQRIKERRDYLRDGLQAAG-LSVlPSQAGFFLLTGLD--PETAKELAQVLLEEvGVYVTPGSSP 326
MalY COG1168
Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor ...
 92-407 1.30e-13

Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440782  Cd Length: 387  Bit Score: 71.66  E-value: 1.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  92 GWDIEPQNIALTNGSQSAFFYLFNLFAgrRADGRVkkVLFPlaPEYIGYADAGLEEDLFVSARPnieLLPEGQfKYHVDF 171
Cdd:COG1168  82 GWEIDPEWIVFTPGVVPGLALAIRAFT--EPGDGV--LIQT--PVYPPFFKAIENNGRELVENP---LILEDG-RYRIDF 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 172 EHL--HIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGI---------PLVIDNAYGVPFPGIifSEArplWNPN 240
Cdd:COG1168 152 DDLeaKLDPGVKLLLLCNPHNPTGRVWTREELERLAELCERHDVlvisdeihaDLVLPGHKHTPFASL--SEE---AADR 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 241 IVLCMSLSK-LGLPGSRCG-IIIANEKI---ITAITNMNGIISLAPGGIgPAM-------------MCEMIKRNdllrls 302
Cdd:COG1168 227 TITLTSPSKtFNLAGLKASyAIIPNPALrarFARALEGLGLPSPNVLGL-VATeaayregeewldeLLAYLRGN------ 299

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 303 etvikpfyYQRVQETIAiirRYLPENRclIHKPEGAIFLWLWFKDLPITTKQLYQRLKAR-GVLMVPGHNFFPGLDkpwp 381
Cdd:COG1168 300 --------RDLLAEFLA---EHLPGVK--VTPPEATYLAWLDCRALGLDDEELAEFLLEKaGVALSDGATFGEGGE---- 362

                       330       340
                ....*....|....*....|....*.
gi 49176374 382 hthQCMRMNYVPEPEKIEAGVKILAE 407
Cdd:COG1168 363 ---GFVRLNFACPRAVLEEALERLAK 385
tyr_nico_aTase TIGR01265
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ...
 56-343 3.32e-13

tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.


Pssm-ID: 188123  Cd Length: 403  Bit Score: 70.83  E-value: 3.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374    56 DMLESGKATdalcNYDGPQGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLap 135
Cdd:TIGR01265  59 DALRSGKFN----GYAPSVGALAAREAVAEYLSSDLPGKLTADDVVLTSGCSQAIEICIEALANPGANILVPRPGFPL-- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   136 eYIGYADA-GLEEDLFvsarpniELLPEGQFKyhVDFEHLH--IGEETGMICVSRPTNPTGNVITDEELLKLDALANQHG 212
Cdd:TIGR01265 133 -YDTRAAFsGLEVRLY-------DLLPEKDWE--IDLDGLEslADEKTVAIVVINPSNPCGSVFSRDHLQKIAEVAEKLG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   213 IPLVIDNAYG------VPF-PGIIFSEARPlwnpnIVLCMSLSK-LGLPGSRCGIIIANE-------KIITAITNMNGII 277
Cdd:TIGR01265 203 IPIIADEIYGhmvfgdAPFiPMASFASIVP-----VLSLGGISKrWVVPGWRLGWIIIHDphgifrdTVLQGLKNLLQRI 277

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49176374   278 sLAPGGIGPAMMCEMIKRNDLLRLSETVIKpfyyqrVQETIAIIRRYLPENRCLI-HKPEGAIFLWL 343
Cdd:TIGR01265 278 -LGPATIVQGALPDILENTPQEFFDGKISV------LKSNAELCYEELKDIPGLVcPKPEGAMYLMV 337
PRK05764 PRK05764
aspartate aminotransferase; Provisional
 78-318 1.75e-12

aspartate aminotransferase; Provisional


Pssm-ID: 235596  Cd Length: 393  Bit Score: 68.23  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   78 ELLTLLAGMLREKLGWDIEPQNIALTNGSQSAffyLFNLFAGRRADGrvKKVLFPlAPEYIGYAD----AGleedlfvsA 153
Cdd:PRK05764  72 ELREAIAAKLKRDNGLDYDPSQVIVTTGAKQA---LYNAFMALLDPG--DEVIIP-APYWVSYPEmvklAG--------G 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  154 RPN-IELLPEGQFKYHVD-FEHlHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAY------GVPF 225
Cdd:PRK05764 138 VPVfVPTGEENGFKLTVEqLEA-AITPKTKALILNSPSNPTGAVYSPEELEAIADVAVEHDIWVLSDEIYeklvydGAEF 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  226 PGIifSEARPLWNPNIVLCMSLSKLG-LPGSRCGIIIANEKIITAITNMNG-IISLAP-----GGI----GP----AMMC 290
Cdd:PRK05764 217 TSI--ASLSPELRDRTITVNGFSKAYaMTGWRLGYAAGPKELIKAMSKLQShSTSNPTsiaqyAAVaalnGPqdevEEMR 294

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 49176374  291 EMIKRN-DLL--RLSE----TVIKP---FY-YQRVQETI 318
Cdd:PRK05764 295 QAFEERrDLMvdGLNEipglECPKPegaFYvFPNVSKLL 333
PRK07568 PRK07568
pyridoxal phosphate-dependent aminotransferase;
65-411 6.59e-12

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 181036  Cd Length: 397  Bit Score: 66.80  E-value: 6.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   65 DALCNYDGP-------QGKTELLTLLAGMLrEKLGWDIEPQNIALTNGSQSAFfyLFNLFAGRRADGRVkkvlfpLAPE- 136
Cdd:PRK07568  50 EAIKNYDEEvlayshsQGIPELREAFAKYY-KKWGIDVEPDEILITNGGSEAI--LFAMMAICDPGDEI------LVPEp 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  137 ----YIGYAD-AGLE--------EDLFvsARPNIEllpegqfkyhvDFEHLhIGEETGMICVSRPTNPTGNVITDEELLK 203
Cdd:PRK07568 121 fyanYNGFATsAGVKivpvttkiEEGF--HLPSKE-----------EIEKL-ITPKTKAILISNPGNPTGVVYTKEELEM 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  204 LDALANQHGIPLVIDNAY------GVPFPGII-FSEARplwnPNIVLCMSLSK-LGLPGSRCGIIIA-NEKIITAitnmn 274
Cdd:PRK07568 187 LAEIAKKHDLFLISDEVYrefvydGLKYTSALsLEGLE----DRVIIIDSVSKrYSACGARIGCLISkNKELIAA----- 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  275 gIISLAPGGIGPAMMcEMIKRNDLLRLSETvikpfYYQRVQETIAIIRRYLPENRCLI-----HKPEGAIFLwlwFKDLP 349
Cdd:PRK07568 258 -AMKLCQARLSPPTL-EQIGAAALLDTPES-----YFDEVREEYKKRRDILYEELNKIpgvvcEKPKGAFYI---IAKLP 327

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49176374  350 IT-----TKQLYQ--RLKARGVLMVPGHNFF--PGLDKpwphthQCMRMNYVPEPEKIEAGVKILAEEIER 411
Cdd:PRK07568 328 VDdaedfAKWLLTdfNYNGETVMVAPASGFYatPGLGK------NEIRIAYVLNEEDLKRAMEILKEALEK 392
PRK07550 PRK07550
aminotransferase;
44-377 1.08e-11

aminotransferase;


Pssm-ID: 181026 [Multi-domain]  Cd Length: 386  Bit Score: 65.75  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   44 PEMQDYFQTLLTDmlesgkatDALCNYdGP-QGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRrA 122
Cdd:PRK07550  45 PELLRALAEAAAD--------PAAHLY-GPvEGLPELREAYAAHYSRLYGAAISPEQVHITSGCNQAFWAAMVTLAGA-G 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  123 DgrvkKVLFPLaPEYI-------------GYADAGLEEDLFVSArPNIELLpegqfkyhvdfehlhIGEETGMICVSRPT 189
Cdd:PRK07550 115 D----EVILPL-PWYFnhkmwldmlgirpVYLPCDEGPGLLPDP-AAAEAL---------------ITPRTRAIALVTPN 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  190 NPTGNVITDEELLKLDALANQHGIPLVIDNAY------GVPfPGIIFSEarPLWNPNIVLCMSLSK-LGLPGSRCGIIIA 262
Cdd:PRK07550 174 NPTGVVYPPELLHELYDLARRHGIALILDETYrdfdsgGGA-PHDLFAD--PDWDDTLVHLYSFSKsYALTGHRVGAVVA 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  263 NEKIITAITNMNGIISLAPGGIGPAMMC---------------EMIKRNDLLRLSETVIKPFyyqrvqETIAIirrylpe 327
Cdd:PRK07550 251 SPARIAEIEKFMDTVAICAPRIGQIAVAwglpnladwragnraEIARRRDAFRAVFARLPGW------ELLAS------- 317

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 49176374  328 nrclihkpeGAIFLWLWFKDLPITTKQLYQRL-KARGVLMVPGHNFFPGLD 377
Cdd:PRK07550 318 ---------GAYFAYVRHPFPDRPSREVARRLaKEAGILCLPGTMFGPGQE 359
PRK06207 PRK06207
pyridoxal phosphate-dependent aminotransferase;
74-411 1.13e-11

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235742  Cd Length: 405  Bit Score: 65.94  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   74 QGKTELLTLLAGMLREKLGWDIEPQ-NIALTNGSQSAFFylfnlFAGRRADGRVKKVLFpLAPEYigYADAGLEEdlFVS 152
Cdd:PRK06207  78 RGDADIRELLAARLAAFTGAPVDAAdELIITPGTQGALF-----LAVAATVARGDKVAI-VQPDY--FANRKLVE--FFE 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  153 ArpniELLPegqfkyhVDFEHLHIGEETGM---------------ICVSRPTNPTGNVITDEELLKLDALANQHGIPLVI 217
Cdd:PRK06207 148 G----EMVP-------VQLDYLSADKRAGLdldqleeafkagvrvFLFSNPNNPAGVVYSAEEIAQIAALARRYGATVIV 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  218 DNAY------GVPFPGIIFSEARPlwnPNIVLCMSLSKL-GLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAM-- 288
Cdd:PRK06207 217 DQLYsrllydGTSYTHLRALPIDP---ENVITIMGPSKTeSLSGYRLGVAFGSPAIIDRMEKLQAIVSLRAAGYSQAVlr 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  289 ---------MCEMIK-----RNDLLRLSETVikpfyyqrvqetiaiirrylpeNRCLIHKPEGAIFLwlwFKDLPITTKQ 354
Cdd:PRK06207 294 twfsepdgwMKDRIArhqaiRDDLLRVLRGV----------------------EGVFVRAPQAGSYL---FPRLPRLAVS 348

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49176374  355 LYQ-----RLKArGVLMVPGHNFFpgldkpwPHTHQCMRMNYVPEPEKIEAGVKILAEEIER 411
Cdd:PRK06207 349 LHDfvkilRLQA-GVIVTPGTEFS-------PHTADSIRLNFSQDHAAAVAAAERIAQLIER 402
PRK08361 PRK08361
aspartate aminotransferase; Provisional
 75-415 5.01e-11

aspartate aminotransferase; Provisional


Pssm-ID: 236248 [Multi-domain]  Cd Length: 391  Bit Score: 63.74  E-value: 5.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   75 GKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADgrvkkVLFPlAPEYIGYA-DAGLEEdlfvsA 153
Cdd:PRK08361  71 GIPELREAIAEYYKKFYGVDVDVDNVIVTAGAYEATYLAFESLLEEGDE-----VIIP-DPAFVCYVeDAKIAE-----A 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  154 RP-NIELLPEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVItDEELLKLDA-LANQHGIPLVIDNaygvPFPGIIFS 231
Cdd:PRK08361 140 KPiRIPLREENEFQPDPDELLELITKRTRMIVINYPNNPTGATL-DKEVAKAIAdIAEDYNIYILSDE----PYEHFLYE 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  232 EAR--PL--WNP-NIVLCMSLSK-LGLPGSRCGIIIANEKIITAITNMNGIIslapggIGPAMMCEMIKRNDLLRLSETv 305
Cdd:PRK08361 215 GAKhyPMikYAPdNTILANSFSKtFAMTGWRLGFVIAPEQVIKDMIKLHAYI------IGNVASFVQIAGIEALRSKES- 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  306 ikpfyYQRVQEtiaiIRRYLPENRCLIHK------------PEGAIFLWLWFKDLPITTKQLYQ-RLKARGVLMVPGHNF 372
Cdd:PRK08361 288 -----WKAVEE----MRKEYNERRKLVLKrlkemphikvfePKGAFYVFANIDETGMSSEDFAEwLLEKARVVVIPGTAF 358

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 49176374  373 fpgldkpWPHTHQCMRMNYVPEPEK-IEAgvkilAEEIERAWAE 415
Cdd:PRK08361 359 -------GKAGEGYIRISYATSKEKlIEA-----MERMEKALEE 390
tyr_amTase_E TIGR01264
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found ...
 95-286 6.14e-10

tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found in animals and Trypanosoma cruzi. It is the first enzyme of a pathway of tyrosine degradation via homogentisate. Several plant enzyme designated as probable tyrosine aminotransferases are very closely related to an experimentally demonstrated nicotianamine aminotransferase, an enzyme in a siderophore (iron uptake chelator) biosynthesis pathway. These plant sequences are excluded from the model seed and score between the trusted an noise cutoffs. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273529 [Multi-domain]  Cd Length: 401  Bit Score: 60.57  E-value: 6.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374    95 IEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLapeYIGYADA-GLEEDLFvsarpniELLPEGQFKYHVDFEH 173
Cdd:TIGR01264  93 IEADDVVLCSGCSHAIEMCIAALANAGQNILVPRPGFPL---YETLAESmGIEVKLY-------NLLPDKSWEIDLKQLE 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   174 LHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYG-VPFPGIIFSEARPLwNPN--IVLCMSLSK- 249
Cdd:TIGR01264 163 SLIDEKTAALIVNNPSNPCGSVFSRQHLEEILAVAERQCLPIIADEIYGdMVFSGATFEPLASL-SSTvpILSCGGLAKr 241

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 49176374   250 LGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGP 286
Cdd:TIGR01264 242 WLVPGWRLGWIIIHDRRGILRDIRDGLVKLSQRILGP 278
PRK08363 PRK08363
alanine aminotransferase; Validated
 69-375 3.59e-09

alanine aminotransferase; Validated


Pssm-ID: 181402  Cd Length: 398  Bit Score: 58.28  E-value: 3.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   69 NYDGP-QGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAffyLFNLFAGRRADGRVKKVLFPLAPEYIGYADaglee 147
Cdd:PRK08363  64 NYYGPsEGLPELREAIVKREKRKNGVDITPDDVRVTAAVTEA---LQLIFGALLDPGDEILIPGPSYPPYTGLVK----- 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  148 dlFVSARPN-IELLPEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYG-VPF 225
Cdd:PRK08363 136 --FYGGVPVeYRTIEEEGWQPDIDDIRKKITEKTKAIAVINPNNPTGALYEKKTLKEILDIAGEHDLPVISDEIYDlMTY 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  226 PGIIFSEARPLWNPNIVLCMSLSKLGL-PGSRCGII--IANEKIITAI-------------TNMNGIISLAPGGIGPA-- 287
Cdd:PRK08363 214 EGKHVSPGSLTKDVPVIVMNGLSKVYFaTGWRLGYIyfVDPEGKLAEVreaidklarirlcPNTPAQFAAIAGLTGPMdy 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  288 ---MMCEMIKRNDLLrlsetvikpfyYQRVQEtiaiirryLPENRCLihKPEGAIFLW------LWFKDLPITTKQLYQr 358
Cdd:PRK08363 294 leeYMKKLKERRDYI-----------YKRLNE--------IPGISTT--KPQGAFYIFprieegPWKDDKEFVLDVLHE- 351

                        330
                 ....*....|....*..
gi 49176374  359 lkaRGVLMVPGHNFFPG 375
Cdd:PRK08363 352 ---AHVLFVHGSGFGEY 365
PRK06836 PRK06836
pyridoxal phosphate-dependent aminotransferase;
38-408 6.27e-09

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180720  Cd Length: 394  Bit Score: 57.51  E-value: 6.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   38 GNPaQIPEMQDYFQTLLTDMLESGKATDAlcnYDGPQGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFnlf 117
Cdd:PRK06836  41 GNP-SVPPPAAVKEALRELAEEEDPGLHG---YMPNAGYPEVREAIAESLNRRFGTPLTADHIVMTCGAAGALNVAL--- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  118 agrradgrvKKVLFP------LAP---EYIGYAD-AG-------LEEDLFvsaRPNIELLPEgqfkyhvdfehlHIGEET 180
Cdd:PRK06836 114 ---------KAILNPgdevivFAPyfvEYRFYVDnHGgklvvvpTDTDTF---QPDLDALEA------------AITPKT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  181 GMICVSRPTNPTGNVITDEELLKLDALANQ------HGIPLVIDNAYG--------VPFPGIIFsearplwnPNIVLCMS 246
Cdd:PRK06836 170 KAVIINSPNNPTGVVYSEETLKALAALLEEkskeygRPIYLISDEPYReivydgaeVPYIFKYY--------DNSIVVYS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  247 LSK-LGLPGSRCGIIIANEKIITAITNMNGIIsLAPGGIG----PAMMCEMIKRNdllrLSETVIKPFYYQRvqetiaii 321
Cdd:PRK06836 242 FSKsLSLPGERIGYIAVNPEMEDADDLVAALV-FANRILGfvnaPALMQRVVAKC----LDATVDVSIYKRN-------- 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  322 RRYLPEN------RCLihKPEGAIFLWLwfKDLPITTKQLYQRLKARGVLMVPGHNF-FPGLdkpwphthqcMRMNYVPE 394
Cdd:PRK06836 309 RDLLYDGltelgfECV--KPQGAFYLFP--KSPEEDDVAFCEKAKKHNLLLVPGSGFgCPGY----------FRLSYCVD 374

                        410
                 ....*....|....*..
gi 49176374  395 PEKIE---AGVKILAEE 408
Cdd:PRK06836 375 TETIErslPAFEKLAKE 391
PLN00143 PLN00143
tyrosine/nicotianamine aminotransferase; Provisional
 14-340 1.69e-08

tyrosine/nicotianamine aminotransferase; Provisional


Pssm-ID: 165711 [Multi-domain]  Cd Length: 409  Bit Score: 56.17  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   14 SGITLLMEDLNDGLRTPgAIMLGGGNPAQIpemqDYFQTllTDMLES---GKATDALCNYDGPQGKT-ELLTLLAGMLRE 89
Cdd:PLN00143  17 DAVKFLKENFNEDDHRL-AISFGFGDPSCF----ECFRT--TNIAEDaivEAVRSAKFNSYAPTGGIlPARRAIADYLSN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   90 KLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLAPEYIGYADAGLEEdlfvsarpnIELLPEGQFKYHV 169
Cdd:PLN00143  90 DLPYQLSPDDVYLTLGCKHAAEIIIKVLARPEANILLPRPGFPDVETYAIFHHLEIRH---------FDLLPEKGWEVDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  170 DFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYG------VPF-PGIIFSEARPlwnpnIV 242
Cdd:PLN00143 161 DAVEAIADENTIAMVIINPGNPCGSVYSYEHLNKIAETARKLGILVIADEVYGhivfgsKPFvPMGLFASIVP-----VI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  243 LCMSLSKLGL-PGSRCGIIIANEKiiTAITNMNGIISLAPGGIGPAMMCEMIKRNDLLRLSETVIKPFYyqrvQETIAII 321
Cdd:PLN00143 236 TLGSISKRWMiPGWGLGWLVTCDP--SGLLQICEIADSIKKALNPAPFPPTFIQAAIPEILEKTTEDFF----SKTINIL 309

                        330       340
                 ....*....|....*....|....*...
gi 49176374  322 RR-------YLPENRCLI--HKPEGAIF 340
Cdd:PLN00143 310 RAalafcydKLKEIPCIMcpQKAEGAFF 337
PRK03321 PRK03321
putative aminotransferase; Provisional
 176-270 3.85e-08

putative aminotransferase; Provisional


Pssm-ID: 179559  Cd Length: 352  Bit Score: 54.59  E-value: 3.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  176 IGEETGMICVSRPTNPTGNVITDEELLK-LDALANqhGIPLVIDNAYG-------VPFpGIIFSEARplwnPNIVLCMSL 247
Cdd:PRK03321 142 ITDRTRLIFVCNPNNPTGTVVTPAELARfLDAVPA--DVLVVLDEAYVeyvrdddVPD-GLELVRDH----PNVVVLRTF 214

                         90       100
                 ....*....|....*....|....
gi 49176374  248 SK-LGLPGSRCGIIIANEKIITAI 270
Cdd:PRK03321 215 SKaYGLAGLRVGYAVGHPEVIAAL 238
PLN00145 PLN00145
tyrosine/nicotianamine aminotransferase; Provisional
 22-341 6.01e-08

tyrosine/nicotianamine aminotransferase; Provisional


Pssm-ID: 215074 [Multi-domain]  Cd Length: 430  Bit Score: 54.39  E-value: 6.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   22 DLNDGLRTpgAIMLGGGNPAQI------PEMQDyfqtLLTDMLESGKATdalcNYDGPQGKTELLTLLAGMLREKLGWDI 95
Cdd:PLN00145  46 DAGGGPRP--VLPLGHGDPSAFpcfrtaPEAED----AVAAALRSGKYN----SYSTCVGLLPARRAIAEYLSRDLPYEL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   96 EPQNIALTNGSQSAFFYLFNLFAGRRADgrvkkVLFPlAPEYIGYAD----AGLEEDLFvsarpniELLPEGQfkYHVDF 171
Cdd:PLN00145 116 STDDIYLTAGCAQAIEIIMSVLAQPGAN-----ILLP-RPGYPLYEAravfSGLEVRHF-------DLLPERG--WEVDL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  172 EHLH--IGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYG------VPF-PGIIFSEARPlwnpniV 242
Cdd:PLN00145 181 EGVEalADENTVAMVIINPNNPCGSVYSYEHLAKIAETARKLGILVIADEVYDhltfgsKPFvPMGVFGEVAP------V 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  243 LCM-SLSKLGL-PGSRCGIIIANE--------KIITAITNMNGiISLAPGGIGPAMMCEMIKRNDLLRLSETVikpfyyQ 312
Cdd:PLN00145 255 LTLgSISKRWVvPGWRLGWIATCDpngilketKVVDSIRNYLN-ISTDPATFVQGAIPQIIANTKEEFFTKTL------G 327

                        330       340       350
                 ....*....|....*....|....*....|.
gi 49176374  313 RVQETIAIIRRYLPENRCLI--HKPEGAIFL 341
Cdd:PLN00145 328 LLKETADICYEKIKEIKCITcpHKPEGSMFV 358
PLN02450 PLN02450
1-aminocyclopropane-1-carboxylate synthase
 183-278 6.47e-07

1-aminocyclopropane-1-carboxylate synthase


Pssm-ID: 178069 [Multi-domain]  Cd Length: 468  Bit Score: 51.29  E-value: 6.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  183 ICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAY-GVPF--PGIIFS---------EARPLWNPNIVLCmSLSK- 249
Cdd:PLN02450 195 VLITNPSNPLGTTTTRTELNLLVDFITAKNIHLISDEIYsGTVFdsPGFVSVmevlkdrklENTDVSNRVHIVY-SLSKd 273

                         90       100       110
                 ....*....|....*....|....*....|..
gi 49176374  250 LGLPGSRCGIIIAN-EKIITAITNMN--GIIS 278
Cdd:PLN02450 274 LGLPGFRVGAIYSNdEMVVSAATKMSsfGLVS 305
PLN02656 PLN02656
tyrosine transaminase
 16-403 1.21e-06

tyrosine transaminase


Pssm-ID: 178262 [Multi-domain]  Cd Length: 409  Bit Score: 50.31  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   16 ITLLMEDLNDGLRTPGAIMLGGGNPAQIP--EMQDYFQTLLTDMLESGKATDALCNYDGPQGKTELLTLLAGMLREKLGW 93
Cdd:PLN02656  17 LSLLMESIDDEENGKRVISLGMGDPTAYScfHTTHVAQEAVVDALQSNKFNGYAPTVGLPQARRAIAEYLSRDLPYKLSL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   94 DiepqNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLAPeyIGYADAGLEEDlfvsarpNIELLPEGQFKYHVDFEH 173
Cdd:PLN02656  97 D----DVFITSGCTQAIDVALSMLARPGANILLPRPGFPIYE--LCAAFRHLEVR-------YVDLLPEKGWEVDLDAVE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  174 LHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYG------VPF-PGIIFSEARPlwnpnIVLCMS 246
Cdd:PLN02656 164 ALADQNTVALVIINPGNPCGNVYSYQHLKKIAETAEKLKILVIADEVYGhlafgsNPFvPMGVFGSIVP-----VLTLGS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  247 LSKLGL-PGSRCGIIIA--------NEKIITAITNMNGIISlapggiGPAMMCEMIKRNDLLRLSETVIKpfyyqrvqET 317
Cdd:PLN02656 239 LSKRWIvPGWRLGWFVTtdpsgsfrDPKIVERIKKYFDILG------GPATFIQAAVPTILEQTDESFFK--------KT 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  318 IAIIRR-------YLPENRCLI--HKPEGAIFLWL-----WFKDLPITTKQLYQRLKARGVLMVPGHNFfpGLdKPWpht 383
Cdd:PLN02656 305 INILKQssdiccdRIKEIPCITcpHKPEGSMAVMVklnlsLLEDISDDIDFCFKLAREESVIILPGTAV--GL-KNW--- 378

                        410       420
                 ....*....|....*....|
gi 49176374  384 hqcMRMNYVPEPEKIEAGVK 403
Cdd:PLN02656 379 ---LRITFAADPSSLEEALG 395
PRK05957 PRK05957
pyridoxal phosphate-dependent aminotransferase;
28-378 1.31e-06

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235654  Cd Length: 389  Bit Score: 50.07  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   28 RTPGAIMLGGG------NPAQIPEMQDYFQTLltdmlESGKatdalcnYDGPQGKTELLTLLAGMLREKLGWDIEPQN-I 100
Cdd:PRK05957  25 ENPGTISLGQGvvsyppPPEAIEALNNFLANP-----ENHK-------YQAVQGIPPLLEAITQKLQQDNGIELNNEQaI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  101 ALTNGSQSAFF------------------YLFNLF-AGRRADGRVkkVLFPlapeyigyADAGLEedlfvsarPNIELLP 161
Cdd:PRK05957  93 VVTAGSNMAFMnailaitdpgdeiilntpYYFNHEmAITMAGCQP--ILVP--------TDDNYQ--------LQPEAIE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  162 EGqfkyhvdfehlhIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAY------GVPfpgiIFSEAR- 234
Cdd:PRK05957 155 QA------------ITPKTRAIVTISPNNPTGVVYPEALLRAVNQICAEHGIYHISDEAYeyftydGVK----HFSPGSi 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  235 PLWNPNIVLCMSLSK-LGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIG--PAMMCEMIKRNdllrlsetvikpfYY 311
Cdd:PRK05957 219 PGSGNHTISLYSLSKaYGFASWRIGYMVIPIHLLEAIKKIQDTILICPPVVSqyAALGALQVGKS-------------YC 285

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 49176374  312 QRVQETIAIIRRYL------PENRCLIHKPEGAIFLWLWFkDLPITTKQLYQRL-KARGVLMVPGHNFfpGLDK 378
Cdd:PRK05957 286 QQHLPEIAQVRQILlkslgqLQDRCTLHPANGAFYCFLKV-NTDLNDFELVKQLiREYRVAVIPGTTF--GMKN 356
PRK07681 PRK07681
LL-diaminopimelate aminotransferase;
146-374 3.35e-06

LL-diaminopimelate aminotransferase;


Pssm-ID: 181081  Cd Length: 399  Bit Score: 49.03  E-value: 3.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  146 EEDLFVsarPNIELLPEgqfkyhvdfehlHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGvpf 225
Cdd:PRK07681 148 KENDFL---PDLELIPE------------EIADKAKMMILNFPGNPVPAMAHEDFFKEVIAFAKKHNIIVVHDFAYA--- 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  226 pGIIFSEARPLWNPNI-------VLCMSLSK-LGLPGSRCGIIIANEKIITAITNMNGiiSLAPGGIGPAM--MCEMIKR 295
Cdd:PRK07681 210 -EFYFDGNKPISFLSVpgakevgVEINSLSKsYSLAGSRIGYMIGNEEIVRALTQFKS--NTDYGVFLPIQkaACAALRN 286

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49176374  296 NDLLRLSETVIkpfyYQRVQETIAiirRYLPENRCLIHKPEGAIFLWLWFKDLPITTKQLYQRLKARGVLMVPGHNFFP 374
Cdd:PRK07681 287 GAAFCEKNRGI----YQERRDTLV---DGFRTFGWNVDKPAGSMFVWAEIPKGWTSLSFAYALMDRANVVVTPGHAFGP 358
PRK07324 PRK07324
transaminase; Validated
 176-411 4.24e-06

transaminase; Validated


Pssm-ID: 235989  Cd Length: 373  Bit Score: 48.40  E-value: 4.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  176 IGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAY-----GVPFPGIIfsearPLWNPNIVLcMSLSK- 249
Cdd:PRK07324 150 VRPNTKLICINNANNPTGALMDRAYLEEIVEIARSVDAYVLSDEVYrpldeDGSTPSIA-----DLYEKGIST-NSMSKt 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  250 LGLPGSRCGIIIANEKIITAIT-----NMngiISlapggigpammCEMIkrNDL-----LRLSETVIkpfyyQR----VQ 315
Cdd:PRK07324 224 YSLPGIRVGWIAANEEVIDILRkyrdyTM---IC-----------AGVF--DDMlaslaLEHRDAIL-----ERnrkiVR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  316 ETIAIIRRYLP-ENRCLIHKPEGAI--FLWLwfkDLPITTKQLYQRL-KARGVLMVPGHNFfpglDKPwphthQCMRMNY 391
Cdd:PRK07324 283 TNLAILDEWVAkEPRVSYVKPKAVStsFVKL---DVDMPSEDFCLKLlKETGVLLVPGNRF----DLE-----GHVRIGY 350

                        250       260
                 ....*....|....*....|
gi 49176374  392 VPEPEKIEAGVKILAEEIER 411
Cdd:PRK07324 351 CCDTETLKKGLKKLSEFLRE 370
PRK06107 PRK06107
aspartate transaminase;
75-342 4.62e-06

aspartate transaminase;


Pssm-ID: 180403  Cd Length: 402  Bit Score: 48.58  E-value: 4.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   75 GKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAffyLFNLFAGRRADGrvKKVLFPlAPEYIGYADAGLEEDlfvsAR 154
Cdd:PRK06107  71 GTPALRKAIIAKLERRNGLHYADNEITVGGGAKQA---IFLALMATLEAG--DEVIIP-APYWVSYPDMVLAND----GT 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  155 PNIELLPEGQ-FKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVI-DNAY------GVPFP 226
Cdd:PRK06107 141 PVIVACPEEQgFKLTPEALEAAITPRTRWLILNAPSNPTGAVYSRAELRALADVLLRHPHVLVLtDDIYdhirfdDEPTP 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  227 GIIfsEARPLWNPNIVLCMSLSK-LGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEMIKRN-DLLRLSET 304
Cdd:PRK06107 221 HLL--AAAPELRDRVLVTNGVSKtYAMTGWRIGYAAGPADLIAAINKLQSQSSSCPSSISQAAAAAALNGDqSFVTESVA 298

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 49176374  305 VikpfYYQRVQETIAIIRRyLPENRCLihKPEGAIFLW 342
Cdd:PRK06107 299 V----YKQRRDYALALLNA-IPGLSCL--VPDGAFYLY 329
PRK08068 PRK08068
transaminase; Reviewed
 153-270 5.62e-06

transaminase; Reviewed


Pssm-ID: 181219  Cd Length: 389  Bit Score: 48.00  E-value: 5.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  153 ARPNIELLP---EGQFkyHVDFEHL--HIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYG-VPFP 226
Cdd:PRK08068 138 ARAQFETMPliaENNF--LPDYTKIpeEVAEKAKLMYLNYPNNPTGAVATKAFFEETVAFAKKHNIGVVHDFAYGaIGFD 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 49176374  227 G---IIFSEARPLWNPNIVLcMSLSKL-GLPGSRCGIIIANEKIITAI 270
Cdd:PRK08068 216 GqkpVSFLQTPGAKDVGIEL-YTLSKTfNMAGWRVAFAVGNESVIEAI 262
PRK06225 PRK06225
pyridoxal phosphate-dependent aminotransferase;
57-272 5.93e-06

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235749 [Multi-domain]  Cd Length: 380  Bit Score: 48.21  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   57 MLESGKAtDALCNYDGPQGKTELLTLLAGMLreklgwDIEPQNIALTNGSQSAFF-------------------YLF-NL 116
Cdd:PRK06225  50 MIRCIEE-GEYCKYPPPEGFPELRELILKDL------GLDDDEALITAGATESLYlvmraflspgdnavtpdpgYLIiDN 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  117 FAgRRADGRVKKVlfPLAPEYIGYadagleedlfvsarpniELLPEGqFKYHVDfehlhigEETGMICVSRPTNPTGNVI 196
Cdd:PRK06225 123 FA-SRFGAEVIEV--PIYSEECNY-----------------KLTPEL-VKENMD-------ENTRLIYLIDPLNPLGSSY 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  197 TDEELLKLDALANQHGIPLVIDNAYGvpfpgiIFSEARPL---WNP-NIVLCMSLSK-LGLPGSRCGIIIANEKIITAIT 271
Cdd:PRK06225 175 TEEEIKEFAEIARDNDAFLLHDCTYR------DFAREHTLaaeYAPeHTVTSYSFSKiFGMAGLRIGAVVATPDLIEVVK 248


                 .
gi 49176374  272 N 272
Cdd:PRK06225 249 S 249
PRK06348 PRK06348
pyridoxal phosphate-dependent aminotransferase;
157-372 9.61e-06

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180537  Cd Length: 384  Bit Score: 47.41  E-value: 9.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  157 IELLPEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGV-----PFPGIIFS 231
Cdd:PRK06348 140 LETYEEDGFQINVKKLEALITSKTKAIILNSPNNPTGAVFSKETLEEIAKIAIEYDLFIISDEVYDGfsfyeDFVPMATL 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  232 EARPlwnPNIVLCMSLSK-LGLPGSRCGIIIANEKIITAITNMN-GIISLAPggigpammcEMIKRNDL--LRLSETVIK 307
Cdd:PRK06348 220 AGMP---ERTITFGSFSKdFAMTGWRIGYVIAPDYIIETAKIINeGICFSAP---------TISQRAAIyaLKHRDTIVP 287

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49176374  308 P---------FY-YQRVqETIAIIRrylpenrclIHKPEGAIFLWLWFKDLPITTKQLYQR-LKARGVLMVPGHNF 372
Cdd:PRK06348 288 LikeefqkrlEYaYKRI-ESIPNLS---------LHPPKGSIYAFINIKKTGLSSVEFCEKlLKEAHVLVIPGKAF 353
PLN02187 PLN02187
rooty/superroot1
 35-221 1.25e-05

rooty/superroot1


Pssm-ID: 215119 [Multi-domain]  Cd Length: 462  Bit Score: 47.41  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   35 LGGGNPAQIPEMQDYFQT--LLTDMLESGKAtdalcNYDGP-QGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFF 111
Cdd:PLN02187  71 LGHGDPSVYPCFRTCIEAedAVVDVLRSGKG-----NSYGPgAGILPARRAVADYMNRDLPHKLTPEDIFLTAGCNQGIE 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  112 YLFNLFAGRRADGRVKKVLFPLAPEYIGYAdaGLEEDLFvsarpniELLPEGQfkYHVDFEHLHI--GEETGMICVSRPT 189
Cdd:PLN02187 146 IVFESLARPNANILLPRPGFPHYDARAAYS--GLEVRKF-------DLLPEKE--WEIDLEGIEAiaDENTVAMVVINPN 214

                        170       180       190
                 ....*....|....*....|....*....|..
gi 49176374  190 NPTGNVITDEELLKLDALANQHGIPLVIDNAY 221
Cdd:PLN02187 215 NPCGNVYSHDHLKKVAETARKLGIMVISDEVY 246
PRK05839 PRK05839
succinyldiaminopimelate transaminase;
65-411 1.48e-05

succinyldiaminopimelate transaminase;


Pssm-ID: 180281  Cd Length: 374  Bit Score: 46.60  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   65 DALCN-------YDGPQGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFY--LFNLFagrraDGRVKKVLFPlAP 135
Cdd:PRK05839  44 DALKNnahllnkYPKSAGEESLREAQRGFFKRRFKIELKENELIPTFGTREVLFNfpQFVLF-----DKQNPTIAYP-NP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  136 EYIGYADAGleedlfVSARPNIELLP---EGQFKYHVDFEHLhigEETGMICVSRPTNPTGNVITDEELLKLDALANQHG 212
Cdd:PRK05839 118 FYQIYEGAA------IASRAKVLLMPltkENDFTPSLNEKEL---QEVDLVILNSPNNPTGRTLSLEELIEWVKLALKHD 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  213 IPLVIDNAYG-----VPFPGIIfsEARPLWN----PNIVLCMSLSK-LGLPGSRCGIIIANEKIITAITNMNGIISLA-P 281
Cdd:PRK05839 189 FILINDECYSeiyenTPPPSLL--EASILVGnesfKNVLVINSISKrSSAPGLRSGFIAGDASILKKYKAYRTYLGCAsP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  282 ggiGPAMMCEMIKRNDllrlsetvikpfyyqrvQETIAIIRRYLPENRCLIHK------PEGAIFLWLWFKDLPITTKQL 355
Cdd:PRK05839 267 ---LPLQKAAAVAWLD-----------------DEHAEFFRNIYAKNLKLAREilgitiPPATFYVWLPVDNDEEFTKKL 326

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 49176374  356 YQRlkaRGVLMVPGHnfFPGLDKPwphTHQCMRMNYVPEPEKIEAGVKILAEEIER 411
Cdd:PRK05839 327 YQN---EGIKVLPGS--FLGRNGI---GKGYVRIALVYDTPKLEKALEIIKTYLEN 374
PRK06108 PRK06108
pyridoxal phosphate-dependent aminotransferase;
75-222 3.29e-05

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180404  Cd Length: 382  Bit Score: 45.70  E-value: 3.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   75 GKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGrrADGRVKkVLFPLAPEYIGYAD-AGleedlfvsA 153
Cdd:PRK06108  62 GIPELREALARYVSRLHGVATPPERIAVTSSGVQALMLAAQALVG--PGDEVV-AVTPLWPNLVAAPKiLG--------A 130

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49176374  154 RP-NIELLPEGQfKYHVDFEHLH--IGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYG 222
Cdd:PRK06108 131 RVvCVPLDFGGG-GWTLDLDRLLaaITPRTRALFINSPNNPTGWTASRDDLRAILAHCRRHGLWIVADEVYE 201
PLN03026 PLN03026
histidinol-phosphate aminotransferase; Provisional
 178-258 4.38e-05

histidinol-phosphate aminotransferase; Provisional


Pssm-ID: 178597  Cd Length: 380  Bit Score: 45.46  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  178 EETGMICVSRPTNPTGNVITDEELLKLDALAnqhgIPLVIDNAYgvpfpgIIFS--EARPLW---NPNIVLCMSLSK-LG 251
Cdd:PLN03026 174 HKPKLLFLTSPNNPDGSIISDDDLLKILELP----ILVVLDEAY------IEFStqESRMKWvkkYDNLIVLRTFSKrAG 243


                 ....*..
gi 49176374  252 LPGSRCG 258
Cdd:PLN03026 244 LAGLRVG 250
PRK07777 PRK07777
putative succinyldiaminopimelate transaminase DapC;
154-221 9.51e-05

putative succinyldiaminopimelate transaminase DapC;


Pssm-ID: 236095 [Multi-domain]  Cd Length: 387  Bit Score: 44.26  E-value: 9.51e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  154 RPNIELLPEGQfKYHVDFEHLH--IGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAY 221
Cdd:PRK07777 133 RVPVPLVPDGR-GFALDLDALRaaVTPRTRALIVNSPHNPTGTVLTAAELAAIAELAVEHDLLVITDEVY 201
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 175-249 1.10e-04

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 44.12  E-value: 1.10e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49176374 175 HIGEETGMICVSRPTNPTGNVITDEELLKLdalANQHGIPLVIDNAYGVPfpgiIFSeaRPL-WNPNIVLcMSLSK 249
Cdd:cd00614 121 AIKPETKLVYVESPTNPTLKVVDIEAIAEL---AHEHGALLVVDNTFATP----YLQ--RPLeLGADIVV-HSATK 186
PRK09147 PRK09147
succinyldiaminopimelate transaminase; Provisional
 160-267 1.93e-04

succinyldiaminopimelate transaminase; Provisional


Pssm-ID: 236393  Cd Length: 396  Bit Score: 43.32  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  160 LPEGQFKyhVDFEHL--HIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGvpfpGIIFSEARPlw 237
Cdd:PRK09147 147 DPANNFA--PDFDAVpaEVWARTQLLFVCSPGNPTGAVLPLDDWKKLFALSDRYGFVIASDECYS----EIYFDEAAP-- 218

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 49176374  238 nP----------------NIVLCMSLSKLG-LPGSRCGIIIANEKII 267
Cdd:PRK09147 219 -PlglleaaaelgrddfkRLVVFHSLSKRSnVPGLRSGFVAGDAALL 264
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 169-263 2.28e-04

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 41.60  E-value: 2.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374 169 VDFEHLHIGEETGMICVSRPTNPTGNVITdeeLLKLDALANQHGIPLVIDNAYGVpfPGIIFSEARPLWNPNIVLCMSLS 248
Cdd:cd01494  82 AILEELKAKPNVALIVITPNTTSGGVLVP---LKEIRKIAKEYGILLLVDAASAG--GASPAPGVLIPEGGADVVTFSLH 156

                        90
                ....*....|....*
gi 49176374 249 KlGLPGSRCGIIIAN 263
Cdd:cd01494 157 K-NLGGEGGGVVIVK 170
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
175-267 2.52e-04

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 42.59  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   175 HIGEETGMICVSRPTNPT-GNVITDEELLKLDALANQHGIPLVIDNA--------YGVPfPGIIFSEARplwnpniVLCM 245
Cdd:pfam01212 124 DIFPPTGLISLENTHNSAgGQVVSLENLREIAALAREHGIPVHLDGArfanaavaLGVI-VKEITSYAD-------SVTM 195

                          90       100
                  ....*....|....*....|....
gi 49176374   246 SLSK-LGLP-GSrcgIIIANEKII 267
Cdd:pfam01212 196 CLSKgLGAPvGS---VLAGSDDFI 216
PRK07908 PRK07908
threonine-phosphate decarboxylase;
95-271 3.14e-04

threonine-phosphate decarboxylase;


Pssm-ID: 236128  Cd Length: 349  Bit Score: 42.68  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374   95 IEPQNIALTNGSQSAFFYLFNLfAGRRAdgrvkKVLFP--LAPEyIGYADAGLEEDLFVSARPniellpegqfkYHVDFE 172
Cdd:PRK07908  73 RTPDEVLLLAGAAEGFALLARL-RPRRA-----AVVHPsfTEPE-AALRAAGIPVHRVVLDPP-----------FRLDPA 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  173 HLHigEETGMICVSRPTNPTGNVITDEELLkldALAnQHGIPLVIDNAYGVPFPGIIFSEArPLWNPNIVLCMSLSKL-G 251
Cdd:PRK07908 135 AVP--DDADLVVIGNPTNPTSVLHPAEQLL---ALR-RPGRILVVDEAFADAVPGEPESLA-GDDLPGVLVLRSLTKTwS 207

                        170       180
                 ....*....|....*....|
gi 49176374  252 LPGSRCGIIIANEKIITAIT 271
Cdd:PRK07908 208 LAGLRVGYALGAPDVLARLT 227
PRK02610 PRK02610
histidinol-phosphate transaminase;
183-270 1.21e-03

histidinol-phosphate transaminase;


Pssm-ID: 235053  Cd Length: 374  Bit Score: 40.85  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  183 ICVSRPTNPTGNVITDEELLKLDALANQhgIPLVIDNAYgvpFPGIIFSEARPLW-NPNIVLCMSLSK-LGLPGSRCGII 260
Cdd:PRK02610 172 VFVVHPNSPTGNPLTAAELEWLRSLPED--ILVVIDEAY---FEFSQTTLVGELAqHPNWVILRTFSKaFRLAAHRVGYA 246

                         90
                 ....*....|
gi 49176374  261 IANEKIITAI 270
Cdd:PRK02610 247 IGHPELIAVL 256
PRK06290 PRK06290
LL-diaminopimelate aminotransferase;
156-269 1.50e-03

LL-diaminopimelate aminotransferase;


Pssm-ID: 235772  Cd Length: 410  Bit Score: 40.41  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  156 NIELLPEGQFkyHVDFEHL--HIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGvpfpGIIFsEA 233
Cdd:PRK06290 156 NLPLLEENNF--LPDLDSIpkDIKEKAKLLYLNYPNNPTGAVATKEFYEEVVDFAKENNIIVVQDAAYA----ALTF-DG 228

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 49176374  234 RPLWNPNI-------VLCMSLSK-LGLPGSRCGIIIANEKIITA 269
Cdd:PRK06290 229 KPLSFLSVpgakevgVEIHSLSKaYNMTGWRLAFVVGNELIVKA 272
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 175-225 2.73e-03

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 2.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 49176374   175 HIGEETGMICVSRPTNPTGNVITDEELLKLdalANQHGIPLVIDNAYGVPF 225
Cdd:pfam01053 128 AIKPNTKAVYLETPTNPLLKVVDIEAIAKL---AKKHGILVVVDNTFASPY 175
PRK08175 PRK08175
aminotransferase; Validated
 182-273 5.12e-03

aminotransferase; Validated


Pssm-ID: 181268 [Multi-domain]  Cd Length: 395  Bit Score: 38.92  E-value: 5.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49176374  182 MICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGvpfpGIIFSEARPlwnPNI----------VLCMSLSK-L 250
Cdd:PRK08175 167 MMILGFPSNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYA----DIVYDGWKA---PSImqvpgakdvaVEFFTLSKsY 239

                         90       100
                 ....*....|....*....|...
gi 49176374  251 GLPGSRCGIIIANEKIITAITNM 273
Cdd:PRK08175 240 NMAGWRIGFMVGNPELVSALARI 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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