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Conserved domains on  [gi|145698332|ref|YP_026256|]
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RffC [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase( domain architecture ID 10013692)

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase participates in Enterobacterial common antigen synthesis where in the final step of synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose it catalyzes the acetylation of the 4-amino group; similar to Escherichia coli WecD

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
38-224 7.96e-114

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


:

Pssm-ID: 182877  Cd Length: 194  Bit Score: 323.42  E-value: 7.96e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  38 LAPWSRVQAKIAASNTGELDALQQLGFSLVEGEVDLALPVNNASD-SGAVVAQETDIPALRQLASAAFAQSRFRAPWYAP 116
Cdd:PRK10975   1 LAAFSLVQAKVAASDTALLDALQQLGFQLVEGEVDFALPVGNASDtTGARVATETDIPALRQLAAQAFAQSRFRAPWYAP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332 117 DASSRFYAQWIENAVRGTFDHQCLILRAASGDIRGYVSLRELNATDARIGLLA------GRGAGAELMQTALNWAYARGK 190
Cdd:PRK10975  81 DDSGRFYAQWIENAVRGTFDHQCLLLRDASGQIQGFVTLRELNDTDARIGLLAvfpgaqGRGIGARLMQAALNWCQARGL 160
                        170       180       190
                 ....*....|....*....|....*....|....
gi 145698332 191 TTLRVATQMGNTAALKRYIQSGANVESTAYWLYR 224
Cdd:PRK10975 161 TRLRVATQMGNLAALRLYIRSGANIESTAYWLYR 194
 
Name Accession Description Interval E-value
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
38-224 7.96e-114

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 323.42  E-value: 7.96e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  38 LAPWSRVQAKIAASNTGELDALQQLGFSLVEGEVDLALPVNNASD-SGAVVAQETDIPALRQLASAAFAQSRFRAPWYAP 116
Cdd:PRK10975   1 LAAFSLVQAKVAASDTALLDALQQLGFQLVEGEVDFALPVGNASDtTGARVATETDIPALRQLAAQAFAQSRFRAPWYAP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332 117 DASSRFYAQWIENAVRGTFDHQCLILRAASGDIRGYVSLRELNATDARIGLLA------GRGAGAELMQTALNWAYARGK 190
Cdd:PRK10975  81 DDSGRFYAQWIENAVRGTFDHQCLLLRDASGQIQGFVTLRELNDTDARIGLLAvfpgaqGRGIGARLMQAALNWCQARGL 160
                        170       180       190
                 ....*....|....*....|....*....|....
gi 145698332 191 TTLRVATQMGNTAALKRYIQSGANVESTAYWLYR 224
Cdd:PRK10975 161 TRLRVATQMGNLAALRLYIRSGANIESTAYWLYR 194
wecD_rffC TIGR02382
TDP-D-fucosamine acetyltransferase; This model represents the WecD protein (Formerly RffC) for ...
44-224 3.62e-110

TDP-D-fucosamine acetyltransferase; This model represents the WecD protein (Formerly RffC) for the biosynthesis of enterobacterial common antigen (ECA), an outer leaflet, outer membrane glycolipid with a trisaccharide repeat unit. WecD is a member of the GNAT family of acetytransferases (pfam00583). [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 131435  Cd Length: 191  Bit Score: 313.83  E-value: 3.62e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332   44 VQAKIAASNTGELDALQQLGFSLVEGEVDLALPVNN----ASDSGAVVAQETDIPALRQLASAAFAQSRFRAPWYAPDAS 119
Cdd:TIGR02382   1 VQAKIAASNLGLLDALQQLGFSLVEGEVDLSLPVNNtenaTSDPGARVATETDIPALRQLASAAFALSRFRAPWYAPDDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  120 SRFYAQWIENAVRGTFDHQCLILRAASGDIRGYVSLRELNATDARIGLLAG------RGAGAELMQTALNWAYARGKTTL 193
Cdd:TIGR02382  81 GRFYAQWVENAVRGTFDHQCLILRDASGDPRGYVTLRELNDTDARIGLLAVfpgaqsRGIGAELMQTALNWCYARGLTRL 160
                         170       180       190
                  ....*....|....*....|....*....|.
gi 145698332  194 RVATQMGNTAALKRYIQSGANVESTAYWLYR 224
Cdd:TIGR02382 161 RVATQMGNTAALRLYIRSGANIESTAYWLYR 191
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
93-212 8.86e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.05  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332   93 IPALRQLASAAFaqsrfraPWYAPDASSRFYAQWIENAVRGTFdhqcliLRAASGDIRGYVSLRELNATDARIGLLA--- 169
Cdd:pfam00583   1 LEALYELLSEEF-------PEPWPDEPLDLLEDWDEDASEGFF------VAEEDGELVGFASLSIIDDEPPVGEIEGlav 67
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 145698332  170 -----GRGAGAELMQTALNWAYARGKTTLRVATQMGNTAALKRYIQSG 212
Cdd:pfam00583  68 apeyrGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLG 115
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
88-206 1.34e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 46.53  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  88 AQETDIPALRQLASAAFAQSRFRAPWYAPDASSRfyAQWIENAVRGtfDHQCLILRAaSGDIRGYVSLRELNATDAR--I 165
Cdd:COG1247    7 ATPEDAPAIAAIYNEAIAEGTATFETEPPSEEER--EAWFAAILAP--GRPVLVAEE-DGEVVGFASLGPFRPRPAYrgT 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 145698332 166 GLLA--------GRGAGAELMQTALNWAYARGKTTLRVATQMGNTAALK 206
Cdd:COG1247   82 AEESiyvdpdarGRGIGRALLEALIERARARGYRRLVAVVLADNEASIA 130
 
Name Accession Description Interval E-value
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
38-224 7.96e-114

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 323.42  E-value: 7.96e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  38 LAPWSRVQAKIAASNTGELDALQQLGFSLVEGEVDLALPVNNASD-SGAVVAQETDIPALRQLASAAFAQSRFRAPWYAP 116
Cdd:PRK10975   1 LAAFSLVQAKVAASDTALLDALQQLGFQLVEGEVDFALPVGNASDtTGARVATETDIPALRQLAAQAFAQSRFRAPWYAP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332 117 DASSRFYAQWIENAVRGTFDHQCLILRAASGDIRGYVSLRELNATDARIGLLA------GRGAGAELMQTALNWAYARGK 190
Cdd:PRK10975  81 DDSGRFYAQWIENAVRGTFDHQCLLLRDASGQIQGFVTLRELNDTDARIGLLAvfpgaqGRGIGARLMQAALNWCQARGL 160
                        170       180       190
                 ....*....|....*....|....*....|....
gi 145698332 191 TTLRVATQMGNTAALKRYIQSGANVESTAYWLYR 224
Cdd:PRK10975 161 TRLRVATQMGNLAALRLYIRSGANIESTAYWLYR 194
wecD_rffC TIGR02382
TDP-D-fucosamine acetyltransferase; This model represents the WecD protein (Formerly RffC) for ...
44-224 3.62e-110

TDP-D-fucosamine acetyltransferase; This model represents the WecD protein (Formerly RffC) for the biosynthesis of enterobacterial common antigen (ECA), an outer leaflet, outer membrane glycolipid with a trisaccharide repeat unit. WecD is a member of the GNAT family of acetytransferases (pfam00583). [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 131435  Cd Length: 191  Bit Score: 313.83  E-value: 3.62e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332   44 VQAKIAASNTGELDALQQLGFSLVEGEVDLALPVNN----ASDSGAVVAQETDIPALRQLASAAFAQSRFRAPWYAPDAS 119
Cdd:TIGR02382   1 VQAKIAASNLGLLDALQQLGFSLVEGEVDLSLPVNNtenaTSDPGARVATETDIPALRQLASAAFALSRFRAPWYAPDDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  120 SRFYAQWIENAVRGTFDHQCLILRAASGDIRGYVSLRELNATDARIGLLAG------RGAGAELMQTALNWAYARGKTTL 193
Cdd:TIGR02382  81 GRFYAQWVENAVRGTFDHQCLILRDASGDPRGYVTLRELNDTDARIGLLAVfpgaqsRGIGAELMQTALNWCYARGLTRL 160
                         170       180       190
                  ....*....|....*....|....*....|.
gi 145698332  194 RVATQMGNTAALKRYIQSGANVESTAYWLYR 224
Cdd:TIGR02382 161 RVATQMGNTAALRLYIRSGANIESTAYWLYR 191
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
93-212 8.86e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.05  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332   93 IPALRQLASAAFaqsrfraPWYAPDASSRFYAQWIENAVRGTFdhqcliLRAASGDIRGYVSLRELNATDARIGLLA--- 169
Cdd:pfam00583   1 LEALYELLSEEF-------PEPWPDEPLDLLEDWDEDASEGFF------VAEEDGELVGFASLSIIDDEPPVGEIEGlav 67
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 145698332  170 -----GRGAGAELMQTALNWAYARGKTTLRVATQMGNTAALKRYIQSG 212
Cdd:pfam00583  68 apeyrGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLG 115
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
88-206 1.34e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 46.53  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  88 AQETDIPALRQLASAAFAQSRFRAPWYAPDASSRfyAQWIENAVRGtfDHQCLILRAaSGDIRGYVSLRELNATDAR--I 165
Cdd:COG1247    7 ATPEDAPAIAAIYNEAIAEGTATFETEPPSEEER--EAWFAAILAP--GRPVLVAEE-DGEVVGFASLGPFRPRPAYrgT 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 145698332 166 GLLA--------GRGAGAELMQTALNWAYARGKTTLRVATQMGNTAALK 206
Cdd:COG1247   82 AEESiyvdpdarGRGIGRALLEALIERARARGYRRLVAVVLADNEASIA 130
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
133-212 4.40e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 44.66  E-value: 4.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332 133 GTFDHQCLILRAASGDIRGYVSLRELNATDARIGLLA------GRGAGAELMQTALNWAYARGKTTLRVATQMGNTAALK 206
Cdd:COG0454   29 GSLAGAEFIAVDDKGEPIGFAGLRRLDDKVLELKRLYvlpeyrGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIR 108

                 ....*.
gi 145698332 207 RYIQSG 212
Cdd:COG0454  109 FYERLG 114
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
151-224 1.55e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 42.34  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332 151 GYVSLRELNATD-ARIGLLA------GRGAGAELMQTALNWAYARGKTTLRVATQMGNTAALKRYIQSGANVESTAYWLY 223
Cdd:COG0456    1 GFALLGLVDGGDeAEIEDLAvdpeyrGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYY 80

                 .
gi 145698332 224 R 224
Cdd:COG0456   81 G 81
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
88-206 1.78e-05

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 43.83  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  88 AQETDIPALRQLASAAFAQSRFRAPWYAPDASSRFYAQWIENAVRGTFdHQCLILRAASGDIRGYVSLRELNATDARIGL 167
Cdd:COG1670   13 LRPEDAEALAELLNDPEVARYLPGPPYSLEEARAWLERLLADWADGGA-LPFAIEDKEDGELIGVVGLYDIDRANRSAEI 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 145698332 168 -------LAGRGAGAELMQTALNWAYAR-GKTTLRVATQMGNTAALK 206
Cdd:COG1670   92 gywlapaYWGKGYATEALRALLDYAFEElGLHRVEAEVDPDNTASIR 138
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
88-197 3.84e-05

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 42.38  E-value: 3.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  88 AQETDIPALRQLASAAFAQSRFrapwyapdassrfyAQWIENAVRGTFDHQCLILRAAsGDIRGYVSLRELNATD----A 163
Cdd:COG3153    4 ATPEDAEAIAALLRAAFGPGRE--------------AELVDRLREDPAAGLSLVAEDD-GEIVGHVALSPVDIDGegpaL 68
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 145698332 164 RIGLLA------GRGAGAELMQTALNWAYARGKTTLRVAT 197
Cdd:COG3153   69 LLGPLAvdpeyrGQGIGRALMRAALEAARERGARAVVLLG 108
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
135-198 6.71e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 41.32  E-value: 6.71e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145698332 135 FDHQCLILRA-ASGDIRGYVSLRELNATDARIGLLA------GRGAGAELMQTALNWAYARGKTTLRVATQ 198
Cdd:COG2153   30 KDEDARHLLAyDDGELVATARLLPPGDGEAKIGRVAvlpeyrGQGLGRALMEAAIEEARERGARRIVLSAQ 100
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
88-197 2.63e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 39.59  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698332  88 AQETDIPALRQLasaafaqsrfRAPWYAPDASSRFYAqwienAVRGtfdhqclilraasGDIRGYVSLRELNATDARIGL 167
Cdd:COG1246    6 ATPDDVPAILEL----------IRPYALEEEIGEFWV-----AEED-------------GEIVGCAALHPLDEDLAELRS 57
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 145698332 168 LA------GRGAGAELMQTALNWAYARGKTTLRVAT 197
Cdd:COG1246   58 LAvhpdyrGRGIGRRLLEALLAEARELGLKRLFLLT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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