Table 3.

Comparison of Primary Hyperoxaluria Types 1, 2, and 3

Gene
(Disorder)		Age of 1st Symptoms 1NephrocalcinosiseGFR 1 at Diagnosis
(mL/min per 1.73 m2)		Plasma Oxalate 1
(µmol/L; nL <1.6)		Urine 1ESKD
at Age 40 Yrs
Oxalate
(mmol per 1.73 m2 per 24 hrs; nL <0.46)		Calcium
(mg per 1.73 m2 per 24 hrs; nL = 100-300)		Citrate
(mg per 1.73 m2 per 24 hrs; nL = 320-1240)
AGXT
(PH1)		Age 4.9 yrs25.5%4812.51.651255~64%
GRHPR
(PH2)		Age 5.7 yrs15.7%834.31.598717~34%
HOGA1
(PH3)		Age 2.7 yrs6.5%962.11.1112638~3%

Adapted from Singh et al [2022b], Table 1

eGFR = estimated glomerular filtration rate; ESKD = end-stage kidney disease; nL = normal limit

1.

Parameters presented are the median.

From: Primary Hyperoxaluria Type 3

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