TABLE 20.1

The Eight Thermosensitive TRP Channels

ReceptorTemperature Threshold for ActivationExpressionOther Effective Stimuli
TRPV143°C <Sensory neurons
Epithelial cells		Capsaicin/proton
Lipids/allicin
2-aminoethoxydiphenyl borate
TRPV252°C <Sensory neurons/brain/spinal cord
Lung/liver/spleen/colon/heart		Mechanical stimulus
2-aminoethoxydiphenyl borate
TRPV332–39°C <Sensory neurons/brain
Spinal cord/skin/stomach/colon		Camphor
2-aminoethoxydiphenyl borate
TRPV427–35°C <Sensory neurons/hypothalamus
Skin/kidney/lung/inner ear		Hypotonic stimulus/4PDD
Mechanical stimulus
Epoxyeicosatrienoic acids
TRPM415~35°CUbiquitousCa2+
TRPM515~35°CTaste cells/pancreasCa2+/Phospholipase C
TRPM8<25–28°CSensory neuronsMenthol
TRPA1<17°CSensory neurons/inner earAllyl isothiocyanate
Δ9-tetrahydrocannabinol
Cinnamaldehyde/allicin
Mechanical stimulus

From: Chapter 20, The Role of TRP Channels in Thermosensation

Cover of TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades.
Liedtke WB, Heller S, editors.
Boca Raton (FL): CRC Press/Taylor & Francis; 2007.
Copyright © 2007, Taylor & Francis Group, LLC.

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