AAre children breastfeeding from a mother diagnosed with Zika virus positively diagnosed with Zika virus infection?

Patient or population: Breastfeeding children from women with suspected, probable or confirmed Zika virus infection

Setting: Areas of Zika virus transmission

Intervention: Children breastfeed from a woman with Zika virus infection

Comparison: Not breastfeeding children

OutcomesNumber of participants (studies)Certainty of the evidence (GRADE)Comments
Confirmed Zika virus infection among children breastfeeding from a woman with suspected, probable or confirmed Zika virus infection7 (3 observational studies)

⊕⊝⊝⊝

VERY LOWa

Three studies provided evidence. One report was not considered due to ambiguous results. The cases reported by two reports were not breastfeeding and therefore were not included in this outcome. The child reported by one report was never breastfed, and the case reported by another was exposed in utero to Zika virus and was born with congenital Zika syndrome, and these two studies were therefore excluded from this analysis.
Confirmed Zika virus infection among children breastfeeding from a woman with suspected, probable or confirmed Zika virus infection: cohort study6 (1 observational study)

⊕⊝⊝⊝

VERY LOWb

One report refers to a cohort study including women with confirmed Zika virus infection. Only an abstract was identified by the search and it reported on six women with Zika virus detected in breast-milk by RT-PCR.

Explanations

a

Downgraded for risk of bias, imprecision and publication bias.

b

Downgraded for risk of bias, imprecision and publication bias.

From: ANNEX 2, GRADE SUMMARY OF FINDINGS TABLES

Cover of Guideline: infant feeding in areas of Zika virus transmission
Guideline: infant feeding in areas of Zika virus transmission [Internet]. 2nd edition.
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