TABLE 37.4.

Examples of glycan receptors for parasites

ParasiteAdhesinGlycan-receptor specificitySite of infection
Entamoeba histolytica 260-kDa surface-anchored lectin on trophozoitesterminal Gal/GalNAc residuesmucosa of human colon
Plasmodium falciparum EBA-175; circumsporozoite (CS) proteinsialic acid–containing O-glycans (Neu5Acα2-3Galβ-) on glycophorins; heparan sulfate proteoglycanserythrocytes (infected cells bind to placental vasculature) and hepatocytes
Trypanosoma cruzi surface “mucins”sialic acid–containing glycans and heparan sulfatemultiple cell types
Leishmania amazonensis unknownheparan sulfatemacrophages, fibroblasts, and epithelium
Cryptosporidium parum lectin p30terminal Gal-GalNAcintestinal epithelium
Giardia lamblia unknownmannose-terminated oligosaccharidesduodenum and small intestine
Toxoplasma gondii microneme protein 1 (TgMIC1)α2-3-linked sialyl-N-acetyllactosamine sequencesintestinal epithelium

From: Chapter 37, Microbial Lectins: Hemagglutinins, Adhesins, and Toxins

Cover of Essentials of Glycobiology
Essentials of Glycobiology [Internet]. 4th edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022.
Copyright © 2022 The Consortium of Glycobiology Editors, La Jolla, California; published by Cold Spring Harbor Laboratory Press; doi:10.1101/glycobiology.4e.37. All rights reserved.

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