Table 14: Zoster Vaccine
Trade Names Shingrix: RZV, adjuvanted
Indications MCCC recommendation: Patients with HIV ≥18 years old (A2)
Administration
  • Two intramuscular doses, given 2 to 6 months apart, regardless of past receipt of ZVL (brand name Zostavax)
  • Perform anti-varicella IgG screening in patients with no known history of chickenpox or shingles [Marin, et al. 2007].
  • See CDC: Adult Immunization Schedule:
    • Recommendations for Ages 19 Years and Older, 2023: HTML | PDF (Table 1)
    • Recommendations by Medical Condition and Other Indication: HTML | PDF (Table 2)
Comments
  • RZV provides strong protection against shingles and post-herpetic neuralgia. Currently, there are no data on immunogenicity specific to people with HIV; however, superior efficacy and longer duration of protection have been demonstrated among the elderly, and a recombinant vaccine is preferred for people with HIV [Anderson, et al. 2022; Dooling, et al. 2018].
  • As of November 2020, ZVL is no longer available for use in the United States.

Abbreviations: CDC, Centers for Disease Control and Prevention; IgG, immunoglobulin G; MCCC, Medical Care Criteria Committee; RZV, recombinant zoster vaccine; ZVL, zoster vaccine live.

From: Immunizations for Adults With HIV

Cover of Immunizations for Adults With HIV
Immunizations for Adults With HIV [Internet].
Kerr C, Dyer M, Urban MA, et al.
Baltimore (MD): Johns Hopkins University; 2024 Apr.
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