TABLE 14.

Changes in Lipids, Lipoproteins, ApoA, and ApoB, by Stage of Chronic Kidney Disease

LIPID PARAMETERCKD 1–5NEPHROTIC
SYNDROME		HEMODIALYSISPERITONEAL
DIALYSIS
Total cholesterol ↗↑↑↔↓↑
LDL cholesterol↗↑↑↔↓↑
HDL cholesterol↓↓↓↓
Non-HDL cholesterol↗↑↑↔↓↑
Triglycerides↗↑↑↑↑
Lp(a)↗↑↑↑↑↑
Apo A-I↘↗↓↓
Apo A-IV↗↑↘↑↑
Apo B↗↑↑↔↓↑

Changes are derived from the combined literature. Non-HDL cholesterol includes cholesterol in LDL, VLDL, intermediate-density lipoprotein, and chylomicron and its remnant. Normal (↔), increased (↑), markedly increased (⇈), and decreased (↓) plasma levels compared with non-uremic individuals; increasing (↗) and decreasing (↘) plasma levels with decreasing glomerular filtration rate (GFR). Apo A, apolipoprotein A; Apo B, apolipoprotein B; CKD, chronic kidney disease; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Lp, lipoprotein; VLDL, very low-density lipoprotein.

SOURCE: Reference (403), copyright © 2007 American Society of Nephrology, reprinted with permission.

From: Kidney Disease and Diabetes

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Diabetes in America [Internet].
Lawrence JM, Casagrande SS, Herman WH, et al., editors.
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