1TGO,1WAF,3IAY,2GV9,1S5J,3K5L


Conserved Protein Domain Family
POLBc

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smart00486: POLBc 
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DNA polymerase type-B family
DNA polymerase alpha, delta, epsilon and zeta chain (eukaryota), DNA polymerases in archaea, DNA polymerase II in e. coli, mitochondrial DNA polymerases and and virus DNA polymerases
Statistics
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PSSM-Id: 214691
Aligned: 97 rows
Threshold Bit Score: 68.7113
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1TGO_A        135 LKMLAFDIETLYHeg--------------eEFa------------EGPILMISYADEEGAR------------------- 169  Thermococcus ...
NP_073685       3 RSVYVCDFETTTDpe--------------dCR-------------LWAWGWMDIYNTDKWSygedi-------------- 41   GA-1
NP_044702     165 RLYVVYDIETYTYhskygk-----qlvpylLVfql--------fgEETLIDLAKAEAEMVGytaydgcfyilnkdpevvg 231  Duck adenovir...
YP_001648062  361 VKEVFFDIESFSDetkhqipylicwsylgeLYyrtg------kncIKEFVEEILSYNVDIIlyawygsg----------y 424  Kluyveromyces...
CAA38621      365 TEEIFFDIESFTNeknfqipylicwsktngSIhkri-----gkncINDFVQYIINLKKNVIlyawfgsg----------y 429  Lachancea klu...
CAA09497      361 KITVCFDIEAYFDpdse---------ndqtHIpy---------lcCACFVYNDVIGNVIEFegrdcva------------ 410  Debaryomyces ...
YP_001648053  358 NITVCFDIESYFDpek------------esNQv------------NIPFICCASIIYNKVIgnivdf------------- 400  Kluyveromyces...
P06950          3 RKMYSCDFETTTKv-------------------------------EDCRVWAYGYMNIEDH------------------- 32   Bacillus phag...
NP_690635       3 RKMFSCDFETTTKl-------------------------------DDCRVWAYGYMEIGN-------------------- 31   Bacillus phag...
NP_047384     172 KLFLIYDIETFTLaetsgv-----llnpllLCfsifgddclinicKTEIAKIKSIQTKNSTyfwfskvknfis---tefr 243  Turkey adenov...
1TGO_A        170 -------VITWKNIDL-----------PYVDVVS-------TEKEMIKRFLKVVKEKDP------DVLITYNGDN---FD 215  Thermococcus ...
NP_073685      42 ---dsfmEWALNSNSD-------------IYFHN---------LKFDGSFILPWWLRNG------YVHTEEDRTNt-pKE 89   GA-1
NP_044702     232 qsfklfrSNLQDKVTNlawerfcednaLDPYSRIt-----aKQLQKLNKSQKLNKTAEPqf--yeIIIVGHNISG---FD 301  Duck adenovir...
YP_001648062  425 dyqhvlpYMKSKCIKDkyii---knnmITYGELYy-----eNAIIYLKDPYLFILTSLD------KASKAFNVINkgeFP 490  Kluyveromyces...
CAA38621      430 dyqhvlpYFKKKCIKDkyii---knnmITYSELYf-----kHSKIILKDPFLFILTSLD------KAAKAFNVINkgsFP 495  Lachancea klu...
CAA09497      411 -qmieyiVDICSELKNk---------nIELIAHNg------GAYDFHYILSSMYKSSDI------KNILIRNNNF---IS 465  Debaryomyces ...
YP_001648053  401 -----egrdcvAQMIE--------------YVVD-------ICGELNISSVE---------------LIAHNGGG---YD 436  Kluyveromyces...
P06950         33 --------------SE--------------YKIG-------NSLDEFMAWVLKVQAD----------LYFHNLK----FD 63   Bacillus phag...
NP_690635      32 ---------------------------LDNYKIG-------NSLDEFMQWVMEIQAD----------LYFHNLK----FD 63   Bacillus phag...
NP_047384     244 klrnnilFALTDYFTKlilt---penrEILEDFAqtqnlesITNINLSEHTNLIMSLKVkpifieFYIIGHNIQS---FD 317  Turkey adenov...
1TGO_A        216 FAYLKKRSEK---LGVK--F---------ILGREGSEp--KIQRMGDRFAVE---------------------------- 251  Thermococcus ...
NP_073685      90 FTTTISGMGQw--YAVDvcIn--------TRGKNKNHvvfYDSLKKLPFKVEqiakg--------------------fgl 139  GA-1
NP_044702     302 EIVLASHILD---NVKDkdYfvmfnitrnFLPRAGKLlfnDITFSLPNPQYKkpsrgtfdrwqn-------gmldkqdlk 371  Duck adenovir...
YP_001648062  491 HSIIHSWEDL---NKILpnWvkiq--krmIEYKDDNKlniYYKNIEIFENDRnynt----------------------il 543  Kluyveromyces...
CAA38621      496 HSLIKDWPDL---QKIYphWikt----qrKIIEFKHDnklNIKINTTLEEDNitnns--------------------tii 548  Lachancea klu...
CAA09497      466 FSFVHDDITF---NIKDsyS---------FLLCSLAN-----AAKAFLSGNHdfgkt---------------------df 507  Debaryomyces ...
YP_001648053  437 FHYILSSMYN---PAA--------------IKNILIR-----NNSFISFNFAhd-------------------------- 468  Kluyveromyces...
P06950         64 GAFIINWLERn------------------GFKWSADG----LPNTYNTIISRmg-------------------------- 95   Bacillus phag...
NP_690635      64 GAFIVNWLEH---HG---------------FKWSNEG----LPNTYNTIISKmg-------------------------- 95   Bacillus phag...
NP_047384     318 EILLATQILQdenLDITplFtve----rnFMPRQGRIlfnDITIKFPNPDYYvakeekknnkseilsqikegiphpesik 393  Turkey adenov...
1TGO_A        252 --VKGRIHFDLYPVIRRTIN---LPTYTLEA---------VYEAIFG----QPKEKVYAE---EIAQAWETg-------- 302  Thermococcus ...
NP_073685     140 pvLKGDIDYKKYRPVGYVMDdneIEYLKHDLl--------IVALALRs---MFDNDFTSMt--VGSDALNTy-------- 198  GA-1
NP_044702     372 wqGVKFMVRDTYLLTHTSLRn-aATAYQLPIskgccpyeaVNEYLMTgnyeQETNGYPTLkywNNADEYHQnkik----- 445  Duck adenovir...
YP_001648062  544 enAIEYCKVDVLAMEKVWIKfkkLLEKNLNIt--------VSVKTFTl--sQLSMKIMESklpKYVKLYVPt-------- 605  Kluyveromyces...
CAA38621      549 ekAIEYCSIDVIAMKQVWQKfkkLVKENLQIs--------ISEKTFTl--sQLSMKIMEAsldRNIELYVPt-------- 610  Lachancea klu...
CAA09497      508 phHDVRSKADLEKVYRKWRSid-----------------nIIDIEIE----KEKLLISSH---NIINYETDgk------- 556  Debaryomyces ...
YP_001648053  469 -----gVKFSVKDSYSFL-----LCSLANAS---------KAFLNEe---tFKKTDFPHHd------------------- 507  Kluyveromyces...
P06950         96 ----qWYMIDICLGYKGKRK---IHTVIYDS---------LKKLPFP------VKKIAKD---FKLTVLKG--------- 141  Bacillus phag...
NP_690635      96 ----qWYMIDICFGYKGKRK---LHTVIYDS---------LKKLPFP------VKKIAKD---FQLPLLKG--------- 141  Bacillus phag...
NP_047384     394 nlYIKSMVRDTFQITHTSLKe-aAKAYNLKIhkgccpfkaINEYMSTnslsTDSDSFPSEkywSSKEEYNEqkeiwlekk 472  Turkey adenov...
1TGO_A        303 ----EGLERVARYSMEDAKVTYELGKE-------FFPMEAQLSRLVGQSLWDVSRSSTGNlVEWFL-----LRKAYERNE 366  Thermococcus ...
NP_073685     199 ----KEMLGVKQWEKYFPVLSLKVNSEi------rKAYKGGFTWVNPKYQGETVYGGMVFdVNSMY-------PAMMKNK 261  GA-1
NP_044702     446 -gpyDILKEALIYCIADVKVTSQLTRKliegyqsFCNDQIKLTCQFHIFQRPTISSNTHAlFKQIL-----YRAEKGQTE 519  Duck adenovir...
YP_001648062  606 ----LEEYSKIRNAIYGGRVISKNGIYee-----nIVYADVVSLYPSAMKLLKHSYGKPKlVDYID-----FEKHGIYRV 671  Kluyveromyces...
CAA38621      611 ----SEEYQFIRNSIYGGRVAAKNGTYn-----eEIVYADVVSLYPSAMKLLEHSYGKPSkVFSIN-----FNKHGIYDV 676  Lachancea klu...
CAA09497      557 --skKLLDWSREYCCNDVIVLAKVWLEfk---iaVYEIFSAKVVDQSYTLAGMSFKLFESnLDPNId----LRHPKKEDY 627  Debaryomyces ...
YP_001648053  508 ---lKTADDLYKVYKEWSSVNTEINHV-------VEKEKLLITSEHIVNF--TKNDKSKTlIEWS--------KDYCRND 567  Kluyveromyces...
P06950        142 -----DIDYHKERPVGYEITPDEYAYIk-----nDIQIIAEALLIQFKQGLDRMTAGSDDlKGFKD-----IITTKKFKK 206  Bacillus phag...
NP_690635     142 -----DIDYHAERPVGHEITPEEYEYIk-----nDIEIIARALDIQFKQGLDRMTAGSDSlKGFKD-----ILSTKKFNK 206  Bacillus phag...
NP_047384     473 evkyDIVKELIDYCIKDVKITEELTKTllntfdtFIKEELNLKCNFNIFKRPTISSNSHAiFRQLHfkqngTKASTLPDI 552  Turkey adenov...
1TGO_A        367 LAPNKpd----------------------------------------------------eRELARRRESYAGG-YVKEPE 393  Thermococcus ...
NP_073685     262 LLPYGepvm--------------------------------------------------fkgEYKKNVEYPLYiQQVRCF 291  GA-1
NP_044702     520 HLPGLqapsekmydhirksvrggrcypsylgvyegpiyvydicgmyasalthpmpfgrteDPLTASISIKTFQdKLDSPA 599  Duck adenovir...
YP_001648062  672 TLLNKhdq------------------------------------------------------epKNYLNFVPR-RINRKL 696  Kluyveromyces...
CAA38621      677 TLIHKsns------------------------------------------------------kpNHYLEFVPR-RIDKKL 701  Lachancea klu...
CAA09497      628 MNMKDsliggrci---------------------------------------svngiyenILCLDVKSLYPAAmAFYDQP 668  Debaryomyces ...
YP_001648053  568 VLVLSkvwlefknavedifncelvdqtmt-------laglsyklfqanmpfdvelrhpnkEDYFNMREALIGG-RCIS-V 638  Kluyveromyces...
P06950        207 VFPTLslg-----------------------------------------------------ldKEVRYAYRGGfTWLNDR 233  Bacillus phag...
NP_690635     207 VFPKLslp-----------------------------------------------------mdKEIRRAYRGGfTWLNDK 233  Bacillus phag...
NP_047384     553 VAPSDemysfirqsvrggrcypthlgifke-----kifvydicgmyasalthpmpygfpiGEKERNNEITKLNeKLKKTK 627  Turkey adenov...
1TGO_A        394 RG-LWENI-----VY-LDFRSLYPS------------IIITHNVSPDTLNREGCe------------------------- 429  Thermococcus ...
NP_073685     292 FElKKDKIp----CIqIKGNARFGQn----------eYLSTSGDEYVDLYVTNv-------------------------- 331  GA-1
NP_044702     600 KLsYFGESi----KPmIVYADCYPPplehvdvlpplcSRKSGRLCWTNEPLLGEvvttidlitlhnrgwkck-------- 667  Duck adenovir...
YP_001648062  697 TWeWFKIHeg--wYHtYDLIIAKSEgf---------dIYCHEGFEYPEKDYIFNdfidtlys------------------ 747  Kluyveromyces...
CAA38621      702 IWsWFKEHrg--tYHtYDLLIAIQEgf---------eIICHSGIEYPNKGYIFNnfidklyt------------------ 752  Lachancea klu...
CAA09497      669 YGqFRRVQqrmteELgIYYVRVIPH------------TKINSNFFPVRYNNKITynnygstqyn---------------- 720  Debaryomyces ...
YP_001648053  639 NG-IYKD------VLcLDVKSLYPA------------SMAFYDQPYGSFKRVSSrpkdelgiyyvrvtpnrnnksnffpi 699  Kluyveromyces...
P06950        234 FK-EKEIGe----GMvFDVNSLYPA------------QMYSRLLPYGEPIVFEG-------------------------- 270  Bacillus phag...
NP_690635     234 YK-EKEIGe----GMvFDVNSLYPS------------QMYSRPLPYGAPIVFQG-------------------------- 270  Bacillus phag...
NP_047384     628 TKlSYFTDik-pmVVmIDAIPPPPEhldpl---pplcSRQSGKLCWTNEILKNEivtsidiitlhnr------------- 690  Turkey adenov...
1TGO_A        430 ---------------------------------------------------------------------E-YDVAPQvGH 439  Thermococcus ...
NP_073685     332 ---------------------------------------------------------------------DwELIKKHyDI 342  GA-1
NP_044702     668 ----------------------------------------------------iltseqlyavwpewkciTkEYVSINiAA 695  Duck adenovir...
YP_001648062  748 --------------------------------------------------------------mkethtaCsCEEQPCpIR 765  Kluyveromyces...
CAA38621      753 --------------------------------------------------------------lkdihtnCkCKEQPCpIR 770  Lachancea klu...
CAA09497      721 ------------------------------------------------------------awytsvdidI-GISEGHdIQ 739  Debaryomyces ...
YP_001648053  700 rshnkitynnfeestyiawytnvdidiglseghnieyipfdsygnigyswskkgkifekyikdvlyklkI-KYEKQN--N 776  Kluyveromyces...
P06950        271 -----------------------------------------------------------------------KYVWDEdYP 279  Bacillus phag...
NP_690635     271 -----------------------------------------------------------------------KYEKDEqYP 279  Bacillus phag...
NP_047384     691 --------------------------------------------------------gwkvniiphklntVfPTWNTCcLE 714  Turkey adenov...
1TGO_A        440 KFCKDFP-----------------GFIPSLLGDLLEERQKVKKKMKATI------------------------------D 472  Thermococcus ...
NP_073685     343 FEEEFIGgf-------------mfKGFIGFFDEYIDRFMEIKNSPDSSA------------------------------E 379  GA-1
NP_044702     696 KEKADKDknmtq--------rsisKLLSNALYGSFATRLDNKKVVFANSmekgdmeriangkatitaqttvintclpkkD 767  Duck adenovir...
YP_001648062  766 MVAKIALn---------------gGGYGKFVQKPIDKEIYIVKRDVVAG------------------------------- 799  Kluyveromyces...
CAA38621      771 MVAKIALn---------------gGGYGKFVQKPIDKEVYIVKRDVVAG------------------------------- 804  Lachancea klu...
CAA09497      740 YIPFDEEe----------------NIGYSWINKGKIFQQYIEDTLYKLK------------------------------- 772  Debaryomyces ...
YP_001648053  777 KVKRNVIkii------------mnSLWGKFAQKWVNFEYFIKSEDDIDF------------------------------- 813  Kluyveromyces...
P06950        280 LHIQHIR-------------------CEFELKEGYIPTIQIKRSRFYKGn------------------------------ 310  Bacillus phag...
NP_690635     280 LYIQRIR-------------------FEFELKEGYIPTIQIKKNPFFKGn------------------------------ 310  Bacillus phag...
NP_047384     715 YVTKNILakekatveknpvkraisKLLSNALYGSFATRESNDITIFENHiqenpkirnqll------nkqltidsittlP 788  Turkey adenov...
1TGO_A        473 PIE--KKLLDYRQRAIKILANSF--------YGYYGYAKA--RWYCKECA---ESVTAWGR----------------QYI 521  Thermococcus ...
NP_073685     380 QSLqaKLMLNSLYGKFATNPDITgkvpyldeNGVLKFRKG----ELKERD---PVYTPMGC----------------FIT 436  GA-1
NP_044702     768 TTSweRFFSNLPQTTALPVAPSTene--gndINPKSFIEGagHVTFKPIThltAACDDLIL----------------SII 829  Duck adenovir...
YP_001648062  800 ECDklQENENGEICIGKRLVKRPl------fYNLDSENYDk-MIIEKEDEp--IYSTQCGI----------------SIL 854  Kluyveromyces...
CAA38621      805 ECEnlSQNENGEICIGKRIVKKPk------fFNLDGEDYDk-MIIERDDDp--IYSTQCGV----------------SIL 859  Lachancea klu...
CAA09497      773 -LKyeEEGNKVKRNVIKIIMNSLwg-----kFAQKWIDTNy-SIKAESDV---DFDEEEAY----------------KIW 826  Debaryomyces ...
YP_001648053  814 ESEeaYKIWDTDFMLIKKIKEST--------------------YSSKPIQ---NGV---------------------FTL 849  Kluyveromyces...
P06950        311 -----EYLKSSGGEIADLWVSNV--------DLELMKEH----YDLYNVE---YISGLKFK----------------ATT 354  Bacillus phag...
NP_690635     311 -----EYLKNSGAEPVELYLTNV--------DLELIQEH----YEMYNVE---YIDGFKFR----------------EKT 354  Bacillus phag...
NP_047384     789 TYNlpYVSIENLTFTLKNRTDSAernl-eldDELTSPFNSleFMDESPASqtsTSTAHVGTykpfnildvtsenltiYML 867  Turkey adenov...
1TGO_A        522 ETTIREIEEKf--------------------------------------------------------------------- 532  Thermococcus ...
NP_073685     437 AYARENILSNaqk------------------------------------------------------------------- 449  GA-1
NP_044702     830 EERSEWIENNryptqiasfvlawtrafts--------------------------------------------ewasflf 865  Duck adenovir...
YP_001648062  855 SASRYRLYKLckq------------------------------------------------------------------- 867  Kluyveromyces...
CAA38621      860 SASRYRLYNLckk------------------------------------------------------------------- 872  Lachancea klu...
CAA09497      827 DTEYMLIKQHkeseysskpiqngvftl-----------------------------------------------swarhh 859  Debaryomyces ...
YP_001648053  850 SWARYHMKSIwdag------------------------------------------------------------------ 863  Kluyveromyces...
P06950        355 GLFKDFIDKWthikttsegaikqlaklmlnslygkfasnpdvtgkvpylkengalgfrlgeeetkdpvytpmgvfitawa 434  Bacillus phag...
NP_690635     355 GLFKEFIDKW---------------------------------------------------------------------- 364  Bacillus phag...
NP_047384     868 KSTNLHPTNKryptqlasfvlawtrafms--------------------------------------------ewreily 903  Turkey adenov...
1TGO_A        533 -----------GFKVLYADTDGFFATIPG 550  Thermococcus gorgonarius
NP_073685     450 ----------lypRFIYADTDSIHVEGLG 468  GA-1
NP_044702     866 eddwgsnienrSLKVVYGDTDSLFLTQHG 894  Duck adenovirus A
YP_001648062  868 ---------fenIDIIYSDTDSIFVKQKS 887  Kluyveromyces lactis
CAA38621      873 ---------fegLEIIYSDTDSIFVRKNT 892  Lachancea kluyveri
CAA09497      860 mkllwdastrpDTECIYSDTDSIFVRKEE 888  Debaryomyces hansenii
YP_001648053  864 --------akeGAECIYSDTDSIFVHKEH 884  Kluyveromyces lactis
P06950        435 ryttitaaqacFDRIIYCDTDSIHLTGTE 463  Bacillus phage PZA
NP_690635     365 ---------------TYVKTHEKGAKKQL 378  Bacillus phage B103
NP_047384     904 sdedsipvqfkTIKSIYGDTDSLFLTEKG 932  Turkey adenovirus A
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